IMP: Integrative Multi-species Prediction

Homo sapiens

156 known processes

PEX14

peroxisomal biogenesis factor 14

(Aliases: MGC12767,dJ734G22.2,Pex14p,NAPP2)

HPRD: 03477
Entrez: 5195
HGNC: 8856
MIM: 601791
Ensembl: ENSG00000142655
UniProtKB: O75381

Process Predictions
Disease Predictions

PEX14 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
protein import into peroxisome matrix	GO:0016558	11	1.000
peroxisome organization	GO:0007031	28	1.000
establishment of protein localization to peroxisome	GO:0072663	15	1.000
peroxisomal transport	GO:0043574	15	1.000
protein localization to peroxisome	GO:0072662	15	1.000
protein targeting to peroxisome	GO:0006625	15	1.000
intracellular protein transmembrane transport	GO:0065002	24	1.000
protein import into peroxisome membrane	GO:0045046	5	1.000
protein to membrane docking	GO:0022615	3	1.000	Yeast
intracellular protein transmembrane import	GO:0044743	23	1.000
carboxylic acid catabolic process	GO:0046395	71	1.000
monocarboxylic acid catabolic process	GO:0072329	37	0.999
cellular lipid catabolic process	GO:0044242	65	0.999
cerebral cortex cell migration	GO:0021795	3	0.999
fatty acid catabolic process	GO:0009062	29	0.999
protein transmembrane transport	GO:0071806	25	0.999
lipid oxidation	GO:0034440	33	0.996
oxidation reduction process	GO:0055114	396	0.996
small molecule catabolic process	GO:0044282	92	0.995
lipid modification	GO:0030258	84	0.994
lipid catabolic process	GO:0016042	84	0.994
telencephalon cell migration	GO:0022029	4	0.991
long chain fatty acid catabolic process	GO:0042758	3	0.990
monocarboxylic acid metabolic process	GO:0032787	185	0.988
transmembrane transport	GO:0055085	399	0.985
very long chain fatty acid metabolic process	GO:0000038	19	0.980
lipid metabolic process	GO:0006629	381	0.977
fatty acid metabolic process	GO:0006631	115	0.966
protein targeting	GO:0006605	187	0.954
protein import	GO:0017038	130	0.950
establishment of protein localization to organelle	GO:0072594	172	0.948
cellular lipid metabolic process	GO:0044255	303	0.945
cerebral cortex development	GO:0021987	10	0.937
single organism cellular localization	GO:1902580	332	0.933
protein import into peroxisome matrix docking	GO:0016560	2	0.892	Yeast
protein localization to organelle	GO:0033365	280	0.882
forebrain development	GO:0030900	26	0.864
protein targeting to membrane	GO:0006612	42	0.809
neuron migration	GO:0001764	11	0.800
cytoplasmic transport	GO:0016482	379	0.795
intracellular protein transport	GO:0006886	270	0.785
pallium development	GO:0021543	10	0.752
membrane organization	GO:0061024	292	0.671
protein localization to membrane	GO:0072657	160	0.649
establishment of protein localization to membrane	GO:0090150	121	0.634
locomotory behavior	GO:0007626	1	0.607
very long chain fatty acid catabolic process	GO:0042760	3	0.602
peroxisome fission	GO:0016559	10	0.589
fatty acid oxidation	GO:0019395	31	0.568
diterpenoid metabolic process	GO:0016101	20	0.523
forebrain cell migration	GO:0021885	4	0.511
peroxisomal membrane transport	GO:0015919	5	0.480
long chain fatty acid metabolic process	GO:0001676	30	0.455
chaperone mediated protein transport	GO:0072321	5	0.453
organic acid catabolic process	GO:0016054	71	0.440
microtubule based process	GO:0007017	210	0.431
nervous system development	GO:0007399	293	0.424
isoprenoid metabolic process	GO:0006720	39	0.407
fatty acid beta oxidation	GO:0006635	22	0.406
head development	GO:0060322	108	0.388
spermatid development	GO:0007286	4	0.332
spermatid differentiation	GO:0048515	4	0.321
retinoid metabolic process	GO:0001523	18	0.317
single organism membrane organization	GO:0044802	268	0.301
steroid metabolic process	GO:0008202	94	0.294
central nervous system development	GO:0007417	123	0.287
telencephalon development	GO:0021537	17	0.282
organic hydroxy compound metabolic process	GO:1901615	147	0.258
protein homotetramerization	GO:0051289	28	0.255
cellular ketone metabolic process	GO:0042180	80	0.228
regulation of cellular component biogenesis	GO:0044087	281	0.200
cell development	GO:0048468	328	0.187
terpenoid metabolic process	GO:0006721	27	0.186
post embryonic development	GO:0009791	2	0.181
brain development	GO:0007420	97	0.173
negative regulation of protein complex assembly	GO:0031333	43	0.154
membrane biogenesis	GO:0044091	13	0.147
negative regulation of cellular component organization	GO:0051129	235	0.144
neurogenesis	GO:0022008	169	0.139
protein oligomerization	GO:0051259	173	0.139
mitochondrial membrane organization	GO:0007006	40	0.135
regulation of protein complex assembly	GO:0043254	147	0.126
endomembrane system organization	GO:0010256	196	0.113
generation of neurons	GO:0048699	152	0.108
myeloid dendritic cell activation	GO:0001773	4	0.103
protein homooligomerization	GO:0051260	100	0.099
ribonucleotide catabolic process	GO:0009261	405	0.098
ion transmembrane transport	GO:0034220	338	0.095
alcohol metabolic process	GO:0006066	114	0.094
response to drug	GO:0042493	81	0.094
behavior	GO:0007610	112	0.091
cerebral cortex neuron differentiation	GO:0021895	1	0.089
purine nucleotide catabolic process	GO:0006195	405	0.088
forebrain generation of neurons	GO:0021872	3	0.084
protein modification by small protein conjugation	GO:0032446	342	0.082
negative regulation of protein oligomerization	GO:0032460	8	0.080
ribonucleoside triphosphate catabolic process	GO:0009203	391	0.079
ribonucleoside monophosphate catabolic process	GO:0009158	158	0.078
purine ribonucleoside triphosphate metabolic process	GO:0009205	411	0.078
ribonucleoside catabolic process	GO:0042454	406	0.077
purine ribonucleoside catabolic process	GO:0046130	398	0.075
regulation of cellular ketone metabolic process	GO:0010565	50	0.070
neuromuscular process	GO:0050905	15	0.069
response to oxidative stress	GO:0006979	121	0.069
dendritic cell differentiation	GO:0097028	13	0.067
lipid transport	GO:0006869	90	0.061
purine nucleoside monophosphate metabolic process	GO:0009126	186	0.058
regulation of growth	GO:0040008	165	0.057
nucleotide catabolic process	GO:0009166	408	0.056
purine ribonucleoside triphosphate catabolic process	GO:0009207	391	0.056
neurological system process	GO:0050877	163	0.055
fatty acid alpha oxidation	GO:0001561	4	0.054
growth	GO:0040007	202	0.052
purine containing compound catabolic process	GO:0072523	411	0.052
regulation of fatty acid oxidation	GO:0046320	9	0.051
lipid biosynthetic process	GO:0008610	177	0.051
purine ribonucleoside metabolic process	GO:0046128	437	0.050
organelle localization	GO:0051640	84	0.049
mitochondrion organization	GO:0007005	156	0.048
regulation of testosterone biosynthetic process	GO:2000224	2	0.048
positive regulation of lipid metabolic process	GO:0045834	50	0.047
cell growth	GO:0016049	160	0.047
nucleoside triphosphate catabolic process	GO:0009143	394	0.045
retinal metabolic process	GO:0042574	8	0.044
organelle assembly	GO:0070925	176	0.043
atp catabolic process	GO:0006200	157	0.042
cellular response to oxidative stress	GO:0034599	85	0.041
positive regulation of catabolic process	GO:0009896	310	0.041
cell division	GO:0051301	168	0.041
protein tetramerization	GO:0051262	47	0.041
blastoderm segmentation	GO:0007350	2	0.041
organic anion transport	GO:0015711	103	0.040
segmentation	GO:0035282	4	0.040
organic acid biosynthetic process	GO:0016053	97	0.040
hematopoietic or lymphoid organ development	GO:0048534	186	0.039
forebrain neuron differentiation	GO:0021879	3	0.039
determination of adult lifespan	GO:0008340	2	0.037
reproductive process	GO:0022414	106	0.037
regulation of lipid catabolic process	GO:0050994	23	0.036
adult locomotory behavior	GO:0008344	1	0.035
anion transport	GO:0006820	161	0.035
nucleoside monophosphate metabolic process	GO:0009123	191	0.035
positive regulation of fatty acid metabolic process	GO:0045923	11	0.034
organelle fission	GO:0048285	149	0.034
purine ribonucleotide catabolic process	GO:0009154	404	0.033
myeloid cell differentiation	GO:0030099	117	0.033
meiotic chromosome segregation	GO:0045132	4	0.032
glycosyl compound catabolic process	GO:1901658	413	0.032
testosterone biosynthetic process	GO:0061370	2	0.032
anterior posterior axis specification	GO:0009948	2	0.031
atp metabolic process	GO:0046034	176	0.031
myeloid dendritic cell differentiation	GO:0043011	3	0.031
anterior posterior axis specification embryo	GO:0008595	2	0.031
nucleoside triphosphate metabolic process	GO:0009141	422	0.030
central nervous system neuron differentiation	GO:0021953	9	0.030
purine nucleoside triphosphate metabolic process	GO:0009144	412	0.029
neuron fate commitment	GO:0048663	2	0.029
multicellular organismal aging	GO:0010259	3	0.029
regulation of neuroblast proliferation	GO:1902692	3	0.028
regulation of neural precursor cell proliferation	GO:2000177	4	0.028
system process	GO:0003008	349	0.028
cellular macromolecular complex assembly	GO:0034622	324	0.027
leukocyte activation	GO:0045321	164	0.027
fatty acid transport	GO:0015908	25	0.026
actin filament based process	GO:0030029	224	0.026
hemopoiesis	GO:0030097	180	0.026
actin cytoskeleton organization	GO:0030036	207	0.026
myeloid leukocyte activation	GO:0002274	34	0.026
lipid localization	GO:0010876	106	0.025
cellular protein complex assembly	GO:0043623	188	0.024
protein monoubiquitination	GO:0006513	39	0.024
anion transmembrane transport	GO:0098656	76	0.024
memory	GO:0007613	3	0.024
purine nucleoside catabolic process	GO:0006152	398	0.024
monocarboxylic acid transport	GO:0015718	32	0.024
regulation of lipid metabolic process	GO:0019216	96	0.024
negative regulation of apoptotic process	GO:0043066	316	0.024
immune system development	GO:0002520	195	0.024
negative regulation of cell death	GO:0060548	345	0.024
mitotic cell cycle	GO:0000278	326	0.024
nucleoside phosphate catabolic process	GO:1901292	412	0.024
circadian behavior	GO:0048512	2	0.023
regulation of cell cycle process	GO:0010564	266	0.023
regulation of cell cycle	GO:0051726	393	0.023
protein folding	GO:0006457	38	0.023
ribonucleoside triphosphate metabolic process	GO:0009199	412	0.022
negative regulation of neural precursor cell proliferation	GO:2000178	1	0.022
regulation of cellular amino acid metabolic process	GO:0006521	6	0.022
positive regulation of developmental process	GO:0051094	314	0.021
salivary gland morphogenesis	GO:0007435	4	0.021
morphogenesis of embryonic epithelium	GO:0016331	4	0.021
neuron differentiation	GO:0030182	138	0.021
positive regulation of growth	GO:0045927	58	0.020
regulation of protein stability	GO:0031647	87	0.020
response to organic cyclic compound	GO:0014070	204	0.020
oocyte development	GO:0048599	1	0.020
organophosphate catabolic process	GO:0046434	430	0.019
cellular amine metabolic process	GO:0044106	41	0.019
negative regulation of stem cell proliferation	GO:2000647	3	0.019
amine metabolic process	GO:0009308	44	0.019
purine nucleoside monophosphate catabolic process	GO:0009128	158	0.019
nucleoside monophosphate catabolic process	GO:0009125	159	0.019
positive regulation of multicellular organism growth	GO:0040018	6	0.019
regulation of growth rate	GO:0040009	1	0.019
cellular amino acid metabolic process	GO:0006520	116	0.019
leukocyte differentiation	GO:0002521	98	0.019
neuroblast proliferation	GO:0007405	4	0.019
protein polyubiquitination	GO:0000209	110	0.019
organophosphate biosynthetic process	GO:0090407	163	0.019
response to toxic substance	GO:0009636	37	0.019
organic cation transport	GO:0015695	13	0.018
positive regulation of cellular component biogenesis	GO:0044089	158	0.018
hindbrain development	GO:0030902	3	0.018
purine ribonucleoside monophosphate catabolic process	GO:0009169	158	0.018
protein localization to endoplasmic reticulum	GO:0070972	19	0.018
small molecule biosynthetic process	GO:0044283	157	0.018
negative regulation of cell proliferation	GO:0008285	228	0.018
secretion by cell	GO:0032940	226	0.018
negative regulation of phosphate metabolic process	GO:0045936	267	0.018
regulation of synaptic plasticity	GO:0048167	3	0.018
protein ubiquitination	GO:0016567	314	0.017
purine containing compound transmembrane transport	GO:0072530	6	0.017
regulation of steroid metabolic process	GO:0019218	32	0.017
purine nucleoside triphosphate catabolic process	GO:0009146	392	0.017
purine ribonucleoside monophosphate metabolic process	GO:0009167	186	0.017
startle response	GO:0001964	3	0.017
peripheral nervous system development	GO:0007422	2	0.017
regulation of cytoskeleton organization	GO:0051493	177	0.016
oocyte differentiation	GO:0009994	2	0.016
actin filament organization	GO:0007015	128	0.016
posttranscriptional regulation of gene expression	GO:0010608	213	0.016
positive regulation of cell proliferation	GO:0008284	301	0.016
nucleoside catabolic process	GO:0009164	408	0.016
multi organism reproductive process	GO:0044703	54	0.016
regulation of cholesterol metabolic process	GO:0090181	4	0.016
sensory perception of pain	GO:0019233	4	0.016
positive regulation of cellular catabolic process	GO:0031331	284	0.016
chromatin organization	GO:0006325	351	0.015
negative regulation of catalytic activity	GO:0043086	335	0.015
developmental growth	GO:0048589	48	0.015
regulation of cellular component movement	GO:0051270	334	0.015
small gtpase mediated signal transduction	GO:0007264	78	0.015
negative regulation of mitotic cell cycle	GO:0045930	102	0.015
regulation of cellular component size	GO:0032535	82	0.015
organic acid transport	GO:0015849	65	0.015
establishment or maintenance of apical basal cell polarity	GO:0035088	2	0.015
myeloid leukocyte differentiation	GO:0002573	60	0.015
regulation of multi organism process	GO:0043900	157	0.015
protein complex disassembly	GO:0043241	52	0.014
morphogenesis of a polarized epithelium	GO:0001738	3	0.014
regeneration	GO:0031099	4	0.014
microtubule cytoskeleton organization	GO:0000226	176	0.014
response to fungus	GO:0009620	4	0.014
negative regulation of programmed cell death	GO:0043069	321	0.014
embryonic camera type eye formation	GO:0060900	2	0.014
regulation of response to external stimulus	GO:0032101	222	0.014
regulation of cell cycle phase transition	GO:1901987	126	0.014
rhythmic behavior	GO:0007622	2	0.014
positive regulation of transferase activity	GO:0051347	227	0.014
single organism reproductive process	GO:0044702	98	0.014
positive regulation of lipid catabolic process	GO:0050996	13	0.014
positive regulation of protein kinase activity	GO:0045860	190	0.014
developmental process involved in reproduction	GO:0003006	66	0.013
cell activation	GO:0001775	213	0.013
regulation of steroid biosynthetic process	GO:0050810	23	0.013
rho protein signal transduction	GO:0007266	26	0.013
synaptic vesicle endocytosis	GO:0048488	2	0.013
reactive nitrogen species metabolic process	GO:2001057	3	0.013
regulation of locomotion	GO:0040012	329	0.013
interspecies interaction between organisms	GO:0044419	156	0.013
regulation of mitotic cell cycle phase transition	GO:1901990	118	0.013
intracellular mrna localization	GO:0008298	1	0.013
microtubule anchoring	GO:0034453	24	0.013
negative regulation of cellular amine metabolic process	GO:0033239	3	0.013
regulation of small gtpase mediated signal transduction	GO:0051056	156	0.013
negative regulation of cellular amino acid metabolic process	GO:0045763	2	0.013
sulfur compound metabolic process	GO:0006790	101	0.013
protein stabilization	GO:0050821	64	0.013
ubiquitin dependent protein catabolic process	GO:0006511	206	0.013
axon cargo transport	GO:0008088	2	0.012
regulation of developmental growth	GO:0048638	30	0.012
regulation of reactive oxygen species biosynthetic process	GO:1903426	3	0.012
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	281	0.012
autophagy	GO:0006914	88	0.012
ribonucleoprotein complex biogenesis	GO:0022613	116	0.012
negative regulation of developmental process	GO:0051093	247	0.012
negative regulation of cell cycle process	GO:0010948	121	0.012
embryo development ending in birth or egg hatching	GO:0009792	34	0.012
embryonic hindlimb morphogenesis	GO:0035116	2	0.012
regulation of cell motility	GO:2000145	299	0.012
positive regulation of cellular amine metabolic process	GO:0033240	7	0.012
maintenance of location	GO:0051235	112	0.012
associative learning	GO:0008306	1	0.012
regulation of cellular response to stress	GO:0080135	244	0.012
gtp metabolic process	GO:0046039	239	0.012
reactive oxygen species biosynthetic process	GO:1903409	4	0.012
long chain fatty acid transport	GO:0015909	18	0.012
cardiac muscle cell contraction	GO:0086003	4	0.011
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.011
nucleoside phosphate biosynthetic process	GO:1901293	109	0.011
compound eye development	GO:0048749	1	0.011
cranial nerve development	GO:0021545	4	0.011
response to axon injury	GO:0048678	1	0.011
regulation of multicellular organism growth	GO:0040014	8	0.011
hyperosmotic response	GO:0006972	4	0.011
organonitrogen compound biosynthetic process	GO:1901566	200	0.011
embryonic epithelial tube formation	GO:0001838	4	0.011
negative regulation of cell cycle	GO:0045786	193	0.011
purine nucleoside transmembrane transport	GO:0015860	6	0.011
positive regulation of protein phosphorylation	GO:0001934	313	0.011
multi organism behavior	GO:0051705	14	0.011
mitotic cell cycle process	GO:1903047	286	0.011
visual learning	GO:0008542	1	0.011
cell cycle phase transition	GO:0044770	173	0.011
nucleocytoplasmic transport	GO:0006913	176	0.011
atp transport	GO:0015867	4	0.011
nuclear division	GO:0000280	128	0.011
mating	GO:0007618	1	0.011
cell morphogenesis	GO:0000902	296	0.011
protein polymerization	GO:0051258	71	0.011
ras protein signal transduction	GO:0007265	73	0.011
convergent extension	GO:0060026	1	0.011
cell projection organization	GO:0030030	252	0.010
protein catabolic process	GO:0030163	325	0.010
positive regulation of kinase activity	GO:0033674	204	0.010
positive regulation of reactive oxygen species metabolic process	GO:2000379	24	0.010
neuromuscular junction development	GO:0007528	3	0.010
viral life cycle	GO:0019058	132	0.010
regulation of cellular amine metabolic process	GO:0033238	11	0.010
hormone metabolic process	GO:0042445	61	0.010
nuclear transport	GO:0051169	179	0.010

PEX14 disease predictions

Disease	DO term ID	Size	Probability
central nervous system disease	DOID:331	186	0.706
nervous system disease	DOID:863	431	0.706
leukodystrophy	DOID:10579	8	0.399
brain disease	DOID:936	73	0.399
cerebral degeneration	DOID:1443	16	0.399
disease of metabolism	DOID:0014667	295	0.171
inherited metabolic disorder	DOID:655	242	0.092
lipid metabolism disorder	DOID:3146	26	0.092
musculoskeletal system disease	DOID:17	223	0.030
muscular disease	DOID:0080000	114	0.020
muscle tissue disease	DOID:66	113	0.020
myopathy	DOID:423	104	0.020
neurodegenerative disease	DOID:1289	102	0.016
cancer	DOID:162	167	0.015
disease of cellular proliferation	DOID:14566	174	0.015
neuropathy	DOID:870	52	0.013
cardiovascular system disease	DOID:1287	106	0.013
immune system disease	DOID:2914	155	0.011
neuromuscular disease	DOID:440	38	0.011

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