IMP: Integrative Multi-species Prediction

Homo sapiens

58 known processes

POLD1

polymerase (DNA directed), delta 1, catalytic subunit 125kDa

(Aliases: CDC2,POLD)

MIM: 174761
Entrez: 5424
HGNC: 9175
Ensembl: ENSG00000062822
HPRD: 08882
UniProtKB: A0A024R4F4
UniProtKB: Q59FA0
UniProtKB: P28340
UniProtKB: M0R2B7

Process Predictions
Disease Predictions

POLD1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
dna replication	GO:0006260	116	0.964
cellular response to dna damage stimulus	GO:0006974	379	0.895
dna repair	GO:0006281	198	0.885
mitotic cell cycle	GO:0000278	326	0.706
negative regulation of cell cycle	GO:0045786	193	0.640
double strand break repair	GO:0006302	101	0.630
dna biosynthetic process	GO:0071897	40	0.549
base excision repair	GO:0006284	21	0.514
post embryonic development	GO:0009791	2	0.511	Worm
microtubule based process	GO:0007017	210	0.470
nucleotide excision repair	GO:0006289	31	0.448
determination of adult lifespan	GO:0008340	2	0.379
mitotic cell cycle phase transition	GO:0044772	162	0.357
dna replication initiation	GO:0006270	6	0.333
regulation of cell cycle process	GO:0010564	266	0.289
dna strand elongation	GO:0022616	5	0.287	Yeast
cellular macromolecule catabolic process	GO:0044265	380	0.252	Yeast
meiosis i	GO:0007127	4	0.226
dna dependent dna replication	GO:0006261	44	0.208	Yeast Mouse Rat
cell cycle checkpoint	GO:0000075	117	0.206
cell development	GO:0048468	328	0.203
cell cycle arrest	GO:0007050	71	0.196
microtubule cytoskeleton organization	GO:0000226	176	0.193
response to uv	GO:0009411	73	0.183
negative regulation of mitotic cell cycle	GO:0045930	102	0.182
regulation of cell cycle	GO:0051726	393	0.177
translesion synthesis	GO:0019985	8	0.155
embryo development	GO:0009790	123	0.146	Worm
g1 s transition of mitotic cell cycle	GO:0000082	78	0.140
non recombinational repair	GO:0000726	14	0.136
mitotic cell cycle process	GO:1903047	286	0.133
mitotic cell cycle checkpoint	GO:0007093	68	0.128
dna damage checkpoint	GO:0000077	68	0.127
mitotic dna damage checkpoint	GO:0044773	28	0.114
cell cycle phase transition	GO:0044770	173	0.113
postreplication repair	GO:0006301	12	0.112
chromosome segregation	GO:0007059	114	0.111
positive regulation of cell cycle process	GO:0090068	106	0.102
cell cycle g2 m phase transition	GO:0044839	43	0.101
single organism reproductive process	GO:0044702	98	0.100
dna conformation change	GO:0071103	113	0.099
cell cycle g1 s phase transition	GO:0044843	80	0.095
regulation of cell cycle phase transition	GO:1901987	126	0.093
reproductive process	GO:0022414	106	0.092
mitotic dna integrity checkpoint	GO:0044774	30	0.088
negative regulation of cell cycle process	GO:0010948	121	0.086
negative regulation of cell death	GO:0060548	345	0.086
regulation of dna metabolic process	GO:0051052	153	0.083
multicellular organismal aging	GO:0010259	3	0.078
spindle organization	GO:0007051	53	0.074
organophosphate catabolic process	GO:0046434	430	0.073
vesicle mediated transport	GO:0016192	371	0.073	Worm
negative regulation of mitotic cell cycle phase transition	GO:1901991	85	0.073
organelle fission	GO:0048285	149	0.072
modification dependent macromolecule catabolic process	GO:0043632	212	0.071
developmental process involved in reproduction	GO:0003006	66	0.071
regulation of mitotic cell cycle phase transition	GO:1901990	118	0.070
regulation of dna replication	GO:0006275	68	0.069
response to abiotic stimulus	GO:0009628	336	0.069
gene silencing	GO:0016458	49	0.064
organelle assembly	GO:0070925	176	0.062
mitotic sister chromatid cohesion	GO:0007064	12	0.062
purine ribonucleoside triphosphate metabolic process	GO:0009205	411	0.061
digestive tract development	GO:0048565	75	0.061
oocyte differentiation	GO:0009994	2	0.059
posttranscriptional regulation of gene expression	GO:0010608	213	0.057
regulation of gene expression epigenetic	GO:0040029	73	0.057
positive regulation of dna metabolic process	GO:0051054	73	0.056
cellular amino acid metabolic process	GO:0006520	116	0.054
response to reactive oxygen species	GO:0000302	61	0.054
cell division	GO:0051301	168	0.054	Worm
positive regulation of cell cycle	GO:0045787	140	0.054
response to light stimulus	GO:0009416	87	0.053
dna recombination	GO:0006310	77	0.052
cellular response to growth factor stimulus	GO:0071363	197	0.052
mitotic spindle organization	GO:0007052	27	0.052
tube development	GO:0035295	125	0.052
regulation of dna dependent dna replication initiation	GO:0030174	3	0.051
rna processing	GO:0006396	255	0.051
dna integrity checkpoint	GO:0031570	71	0.049
regulation of mitotic cell cycle	GO:0007346	189	0.049
female gamete generation	GO:0007292	2	0.049
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.048
dna damage response signal transduction by p53 class mediator	GO:0030330	44	0.047
dna duplex unwinding	GO:0032508	30	0.047
dna synthesis involved in dna repair	GO:0000731	6	0.046
atp catabolic process	GO:0006200	157	0.044
embryo development ending in birth or egg hatching	GO:0009792	34	0.044	Worm
negative regulation of programmed cell death	GO:0043069	321	0.043
dna geometric change	GO:0032392	32	0.042
ras protein signal transduction	GO:0007265	73	0.040
negative regulation of phosphate metabolic process	GO:0045936	267	0.040
regulation of chromosome organization	GO:0033044	103	0.039
purine containing compound catabolic process	GO:0072523	411	0.039
ribonucleoside triphosphate catabolic process	GO:0009203	391	0.038
regulation of cell cycle arrest	GO:0071156	36	0.037
ribonucleoside catabolic process	GO:0042454	406	0.037
chromatin silencing	GO:0006342	12	0.037
protein catabolic process	GO:0030163	325	0.036
sex differentiation	GO:0007548	45	0.036
positive regulation of hydrolase activity	GO:0051345	331	0.036
nucleoside monophosphate catabolic process	GO:0009125	159	0.035
anatomical structure formation involved in morphogenesis	GO:0048646	284	0.035
covalent chromatin modification	GO:0016569	254	0.034
positive regulation of cell proliferation	GO:0008284	301	0.034
chromatin modification	GO:0016568	298	0.034
positive regulation of cell cycle arrest	GO:0071158	23	0.033
nuclear division	GO:0000280	128	0.033
negative regulation of protein metabolic process	GO:0051248	391	0.033
response to oxygen containing compound	GO:1901700	369	0.033
negative regulation of apoptotic process	GO:0043066	316	0.033
response to inorganic substance	GO:0010035	127	0.032
cellular component morphogenesis	GO:0032989	314	0.032
purine nucleoside triphosphate catabolic process	GO:0009146	392	0.031
cellular macromolecular complex assembly	GO:0034622	324	0.031
positive regulation of protein phosphorylation	GO:0001934	313	0.031
purine ribonucleotide catabolic process	GO:0009154	404	0.030
dephosphorylation	GO:0016311	209	0.030
purine ribonucleoside triphosphate catabolic process	GO:0009207	391	0.029
positive regulation of mitotic cell cycle	GO:0045931	60	0.029
regulation of dna repair	GO:0006282	47	0.029
protein processing	GO:0016485	226	0.029
oocyte maturation	GO:0001556	1	0.029
gene conversion	GO:0035822	1	0.028
centrosome organization	GO:0051297	58	0.028
nucleoside catabolic process	GO:0009164	408	0.028
nucleoside triphosphate metabolic process	GO:0009141	422	0.027
purine nucleotide catabolic process	GO:0006195	405	0.027
protein modification by small protein conjugation	GO:0032446	342	0.026
atp metabolic process	GO:0046034	176	0.026
regulation of cell cycle g1 s phase transition	GO:1902806	42	0.026
nucleic acid phosphodiester bond hydrolysis	GO:0090305	102	0.026	Yeast Mouse
negative regulation of cellular protein metabolic process	GO:0032269	353	0.026
nervous system development	GO:0007399	293	0.026
negative regulation of gene expression epigenetic	GO:0045814	19	0.025
regulation of response to dna damage stimulus	GO:2001020	94	0.025
sister chromatid cohesion	GO:0007062	24	0.024
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	GO:1901030	3	0.024
myosin filament assembly	GO:0031034	2	0.024
glycosyl compound catabolic process	GO:1901658	413	0.024
purine ribonucleoside metabolic process	GO:0046128	437	0.024
regulation of proteolysis	GO:0030162	293	0.023
positive regulation of programmed cell death	GO:0043068	249	0.023
regulation of chromosome segregation	GO:0051983	44	0.023
chromatin organization	GO:0006325	351	0.023
organ morphogenesis	GO:0009887	147	0.023
spermatid development	GO:0007286	4	0.022
alpha amino acid metabolic process	GO:1901605	72	0.022
nucleoside monophosphate metabolic process	GO:0009123	191	0.022
nucleoside phosphate catabolic process	GO:1901292	412	0.022
leukocyte apoptotic process	GO:0071887	31	0.022
regulation of cellular ketone metabolic process	GO:0010565	50	0.022
neurogenesis	GO:0022008	169	0.022
immune response	GO:0006955	307	0.022
stem cell differentiation	GO:0048863	93	0.021
positive regulation of dna repair	GO:0045739	25	0.021
response to oxidative stress	GO:0006979	121	0.021
negative regulation of catalytic activity	GO:0043086	335	0.021
regulation of cellular amino acid metabolic process	GO:0006521	6	0.021
response to growth factor	GO:0070848	205	0.021
response to other organism	GO:0051707	261	0.021
interspecies interaction between organisms	GO:0044419	156	0.021
purine ribonucleoside monophosphate catabolic process	GO:0009169	158	0.021
rna interference	GO:0016246	4	0.020
positive regulation of cellular catabolic process	GO:0031331	284	0.020
purine ribonucleoside catabolic process	GO:0046130	398	0.020
response to radiation	GO:0009314	151	0.020
regulation of meiotic cell cycle	GO:0051445	4	0.020
cellular response to abiotic stimulus	GO:0071214	117	0.019
regulation of g1 s transition of mitotic cell cycle	GO:2000045	40	0.019
dna damage response signal transduction resulting in transcription	GO:0042772	12	0.019
ribonucleotide catabolic process	GO:0009261	405	0.019
negative regulation of intracellular signal transduction	GO:1902532	183	0.019
protein maturation	GO:0051604	233	0.019
negative regulation of cell cycle phase transition	GO:1901988	89	0.019
ubiquitin dependent protein catabolic process	GO:0006511	206	0.018
positive regulation of catabolic process	GO:0009896	310	0.018
myosin filament organization	GO:0031033	2	0.018
generation of neurons	GO:0048699	152	0.018
mitotic nuclear division	GO:0007067	119	0.018
detection of stimulus	GO:0051606	85	0.018
ribonucleoside triphosphate metabolic process	GO:0009199	412	0.018
protein ubiquitination	GO:0016567	314	0.018
digestive system development	GO:0055123	75	0.018
purine nucleoside monophosphate metabolic process	GO:0009126	186	0.017
cellular protein catabolic process	GO:0044257	261	0.017
gonad development	GO:0008406	34	0.017
oogenesis	GO:0048477	2	0.017
multi organism cellular process	GO:0044764	156	0.017
regulation of peptidase activity	GO:0052547	180	0.017
intrinsic apoptotic signaling pathway in response to dna damage	GO:0008630	50	0.017
response to biotic stimulus	GO:0009607	276	0.017
cellular modified amino acid metabolic process	GO:0006575	64	0.016
microtubule organizing center organization	GO:0031023	62	0.016
sister chromatid segregation	GO:0000819	54	0.016
positive regulation of cellular amine metabolic process	GO:0033240	7	0.016
epithelium development	GO:0060429	227	0.016
spermatid differentiation	GO:0048515	4	0.016
histone modification	GO:0016570	251	0.016
g2 m transition of mitotic cell cycle	GO:0000086	41	0.016
cell morphogenesis	GO:0000902	296	0.016
regulation of apoptotic signaling pathway	GO:2001233	175	0.016
membrane organization	GO:0061024	292	0.016
cell growth	GO:0016049	160	0.015
multi organism reproductive process	GO:0044703	54	0.015
nucleotide catabolic process	GO:0009166	408	0.015
positive regulation of proteolysis	GO:0045862	142	0.015
regulation of multi organism process	GO:0043900	157	0.015
apoptotic signaling pathway	GO:0097190	268	0.015
reproduction	GO:0000003	63	0.015
humoral immune response	GO:0006959	49	0.015
response to oxygen levels	GO:0070482	100	0.015
regulation of cell diameter	GO:0060305	1	0.015
regeneration	GO:0031099	4	0.015
signal transduction in response to dna damage	GO:0042770	57	0.015
positive regulation of response to dna damage stimulus	GO:2001022	43	0.014
regulation of cellular amine metabolic process	GO:0033238	11	0.014
maintenance of dna repeat elements	GO:0043570	4	0.014
generation of precursor metabolites and energy	GO:0006091	68	0.014
cellular amine metabolic process	GO:0044106	41	0.014
positive regulation of cell death	GO:0010942	263	0.014
maintenance of location	GO:0051235	112	0.014
negative regulation of cell proliferation	GO:0008285	228	0.014
enzyme linked receptor protein signaling pathway	GO:0007167	303	0.014
deoxyribose phosphate metabolic process	GO:0019692	6	0.014
response to fungus	GO:0009620	4	0.014
reproductive system development	GO:0061458	56	0.013
response to external biotic stimulus	GO:0043207	261	0.013
regulation of cellular response to stress	GO:0080135	244	0.013
purine nucleoside catabolic process	GO:0006152	398	0.013
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	281	0.013
2 deoxyribonucleotide metabolic process	GO:0009394	6	0.013
proteolysis involved in cellular protein catabolic process	GO:0051603	244	0.013
compound eye development	GO:0048749	1	0.013
regulation of immune effector process	GO:0002697	91	0.012
cilium morphogenesis	GO:0060271	75	0.012
response to organic cyclic compound	GO:0014070	204	0.012
signal transduction by p53 class mediator	GO:0072331	72	0.012
positive regulation of organelle organization	GO:0010638	195	0.012
cell projection organization	GO:0030030	252	0.012
sensory organ development	GO:0007423	52	0.012
growth	GO:0040007	202	0.012
dna packaging	GO:0006323	77	0.012
nucleotide biosynthetic process	GO:0009165	109	0.012
small gtpase mediated signal transduction	GO:0007264	78	0.012
nucleoside triphosphate catabolic process	GO:0009143	394	0.012
rna phosphodiester bond hydrolysis	GO:0090501	35	0.012
cell fate determination	GO:0001709	3	0.012
viral life cycle	GO:0019058	132	0.012
nucleus organization	GO:0006997	28	0.012
regulation of proteasomal protein catabolic process	GO:0061136	87	0.012
regulation of protein localization	GO:0032880	296	0.012
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	116	0.012
cellular component assembly involved in morphogenesis	GO:0010927	73	0.011
immune effector process	GO:0002252	159	0.011
positive regulation of developmental process	GO:0051094	314	0.011
multicellular organismal reproductive process	GO:0048609	40	0.011
negative regulation of dna metabolic process	GO:0051053	57	0.011
peptidyl tyrosine dephosphorylation	GO:0035335	36	0.011
intrinsic apoptotic signaling pathway	GO:0097193	127	0.011
protein localization to organelle	GO:0033365	280	0.011
peptidyl lysine modification	GO:0018205	144	0.011
epithelial cell differentiation	GO:0030855	141	0.011
lymphocyte activation	GO:0046649	133	0.011
metaphase anaphase transition of cell cycle	GO:0044784	21	0.011
eye development	GO:0001654	42	0.010
cilium assembly	GO:0042384	63	0.010
regulation of kinase activity	GO:0043549	314	0.010
adult locomotory behavior	GO:0008344	1	0.010
positive regulation of apoptotic process	GO:0043065	246	0.010
protein oligomerization	GO:0051259	173	0.010
purine nucleoside triphosphate metabolic process	GO:0009144	412	0.010
meiotic chromosome segregation	GO:0045132	4	0.010
regulation of viral genome replication	GO:0045069	48	0.010
hemopoiesis	GO:0030097	180	0.010
symbiosis encompassing mutualism through parasitism	GO:0044403	156	0.010

POLD1 disease predictions

Disease	DO term ID	Size	Probability
cancer	DOID:162	167	0.079
disease of cellular proliferation	DOID:14566	174	0.079
disease of metabolism	DOID:0014667	295	0.035
musculoskeletal system disease	DOID:17	223	0.029
connective tissue disease	DOID:65	109	0.029
bone disease	DOID:0080001	88	0.029
bone development disease	DOID:0080006	55	0.028
neuropathy	DOID:870	52	0.014
peripheral neuropathy	DOID:0060053	12	0.014
nervous system disease	DOID:863	431	0.014
organ system cancer	DOID:0050686	164	0.013
dysostosis	DOID:1934	22	0.013
gastrointestinal system cancer	DOID:3119	52	0.011
large intestine cancer	DOID:5672	29	0.005
intestinal cancer	DOID:10155	29	0.005
colorectal cancer	DOID:9256	29	0.004

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