| protein ubiquitination | GO:0016567 | 314 | 0.993 | |
| protein modification by small protein conjugation | GO:0032446 | 342 | 0.990 | |
| adenylate cyclase modulating g protein coupled receptor signaling pathway | GO:0007188 | 43 | 0.973 | |
| cation homeostasis | GO:0055080 | 189 | 0.957 | |
| cellular ketone metabolic process | GO:0042180 | 80 | 0.954 | |
| cellular amino acid metabolic process | GO:0006520 | 116 | 0.951 | |
| metal ion homeostasis | GO:0055065 | 169 | 0.946 | |
| regulation of blood vessel size | GO:0050880 | 18 | 0.944 | |
| dopamine receptor signaling pathway | GO:0007212 | 10 | 0.934 | |
| regulation of mapk cascade | GO:0043408 | 262 | 0.929 | |
| regulation of tube size | GO:0035150 | 18 | 0.927 | |
| cellular response to oxygen containing compound | GO:1901701 | 276 | 0.922 | Fly |
| positive regulation of cell proliferation | GO:0008284 | 301 | 0.913 | Mouse |
| positive regulation of mapk cascade | GO:0043410 | 190 | 0.910 | |
| positive regulation of apoptotic process | GO:0043065 | 246 | 0.910 | Mouse Rat |
| blood vessel morphogenesis | GO:0048514 | 162 | 0.901 | Mouse |
| positive regulation of hydrolase activity | GO:0051345 | 331 | 0.897 | |
| modification dependent protein catabolic process | GO:0019941 | 209 | 0.895 | |
| amino acid betaine transport | GO:0015838 | 4 | 0.884 | |
| negative regulation of phosphatidylinositol 3 kinase signaling | GO:0014067 | 4 | 0.882 | |
| regulation of cellular amine metabolic process | GO:0033238 | 11 | 0.876 | |
| response to abiotic stimulus | GO:0009628 | 336 | 0.863 | Worm |
| response to oxygen containing compound | GO:1901700 | 369 | 0.860 | Rat Fly |
| cellular homeostasis | GO:0019725 | 196 | 0.856 | |
| negative regulation of insulin secretion involved in cellular response to glucose stimulus | GO:0061179 | 1 | 0.854 | |
| enzyme linked receptor protein signaling pathway | GO:0007167 | 303 | 0.853 | Rat Fly |
| mapk cascade | GO:0000165 | 288 | 0.848 | |
| amine metabolic process | GO:0009308 | 44 | 0.837 | |
| cellular lipid metabolic process | GO:0044255 | 303 | 0.836 | |
| adenylate cyclase activating dopamine receptor signaling pathway | GO:0007191 | 3 | 0.814 | |
| regulation of cellular amino acid metabolic process | GO:0006521 | 6 | 0.798 | |
| positive regulation of protein phosphorylation | GO:0001934 | 313 | 0.797 | |
| phospholipase c activating g protein coupled receptor signaling pathway | GO:0007200 | 15 | 0.796 | |
| regulation of anatomical structure morphogenesis | GO:0022603 | 286 | 0.785 | Mouse Fly |
| negative regulation of cell death | GO:0060548 | 345 | 0.785 | Mouse |
| sensory perception of pain | GO:0019233 | 4 | 0.785 | |
| ras protein signal transduction | GO:0007265 | 73 | 0.773 | |
| positive regulation of phosphorylation | GO:0042327 | 394 | 0.773 | |
| cyclic nucleotide metabolic process | GO:0009187 | 82 | 0.761 | |
| cellular amine metabolic process | GO:0044106 | 41 | 0.758 | |
| phosphatidylinositol mediated signaling | GO:0048015 | 55 | 0.750 | |
| negative regulation of transport | GO:0051051 | 176 | 0.749 | Rat Worm |
| positive regulation of programmed cell death | GO:0043068 | 249 | 0.744 | Mouse Rat |
| regulation of hemostasis | GO:1900046 | 42 | 0.743 | |
| regulation of kinase activity | GO:0043549 | 314 | 0.740 | |
| cellular response to nitrogen compound | GO:1901699 | 144 | 0.738 | Fly |
| positive regulation of transport | GO:0051050 | 336 | 0.734 | |
| signal transduction by phosphorylation | GO:0023014 | 297 | 0.732 | |
| negative regulation of phosphorus metabolic process | GO:0010563 | 267 | 0.725 | |
| response to nitrogen compound | GO:1901698 | 184 | 0.725 | Rat Fly |
| vesicle mediated transport | GO:0016192 | 371 | 0.723 | Rat |
| g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger | GO:0007187 | 43 | 0.722 | |
| female gamete generation | GO:0007292 | 2 | 0.720 | |
| regulation of system process | GO:0044057 | 101 | 0.710 | Mouse |
| regulation of apoptotic signaling pathway | GO:2001233 | 175 | 0.706 | Mouse |
| positive regulation of apoptotic signaling pathway | GO:2001235 | 70 | 0.696 | Mouse |
| adenylate cyclase inhibiting adrenergic receptor signaling pathway | GO:0071881 | 1 | 0.695 | |
| regulation of intracellular transport | GO:0032386 | 195 | 0.682 | Worm |
| system process | GO:0003008 | 349 | 0.681 | Mouse Rat Worm |
| negative regulation of phosphate metabolic process | GO:0045936 | 267 | 0.669 | |
| positive regulation of developmental process | GO:0051094 | 314 | 0.667 | |
| ion homeostasis | GO:0050801 | 230 | 0.665 | |
| regulation of protein kinase activity | GO:0045859 | 289 | 0.661 | |
| regulation of cyclase activity | GO:0031279 | 19 | 0.660 | |
| negative regulation of protein kinase b signaling | GO:0051898 | 17 | 0.654 | |
| receptor internalization | GO:0031623 | 43 | 0.652 | |
| dephosphorylation | GO:0016311 | 209 | 0.648 | |
| regulation of cellular ketone metabolic process | GO:0010565 | 50 | 0.645 | |
| defense response | GO:0006952 | 315 | 0.638 | Fly |
| apoptotic signaling pathway | GO:0097190 | 268 | 0.635 | Mouse |
| positive regulation of erk1 and erk2 cascade | GO:0070374 | 75 | 0.634 | |
| regulation of stress activated mapk cascade | GO:0032872 | 84 | 0.632 | |
| chemical homeostasis | GO:0048878 | 306 | 0.618 | |
| organic hydroxy compound transport | GO:0015850 | 63 | 0.618 | |
| cellular response to endogenous stimulus | GO:0071495 | 336 | 0.613 | Fly |
| regulation of transferase activity | GO:0051338 | 355 | 0.604 | |
| long term memory | GO:0007616 | 2 | 0.602 | |
| regulation of phosphatidylinositol 3 kinase signaling | GO:0014066 | 35 | 0.595 | |
| memory | GO:0007613 | 3 | 0.589 | Rat |
| positive regulation of cellular component organization | GO:0051130 | 376 | 0.578 | |
| regulation of cell cycle | GO:0051726 | 393 | 0.576 | |
| cellular divalent inorganic cation homeostasis | GO:0072503 | 128 | 0.569 | |
| regulation of the force of heart contraction | GO:0002026 | 6 | 0.566 | |
| negative regulation of apoptotic process | GO:0043066 | 316 | 0.563 | Mouse |
| positive regulation of cell death | GO:0010942 | 263 | 0.562 | Mouse Rat |
| metal ion transport | GO:0030001 | 272 | 0.561 | |
| regulation of proteolysis | GO:0030162 | 293 | 0.560 | |
| cation transport | GO:0006812 | 331 | 0.559 | |
| cellular cation homeostasis | GO:0030003 | 163 | 0.554 | |
| calcium ion homeostasis | GO:0055074 | 122 | 0.551 | |
| positive regulation of protein kinase activity | GO:0045860 | 190 | 0.545 | |
| response to lipid | GO:0033993 | 206 | 0.545 | Rat |
| cellular macromolecule catabolic process | GO:0044265 | 380 | 0.540 | |
| ubiquitin dependent protein catabolic process | GO:0006511 | 206 | 0.536 | |
| positive regulation of ion transport | GO:0043270 | 87 | 0.535 | |
| regulation of mitotic cell cycle | GO:0007346 | 189 | 0.535 | |
| nitrogen compound transport | GO:0071705 | 191 | 0.534 | |
| cellular response to organic cyclic compound | GO:0071407 | 127 | 0.533 | |
| regulation of map kinase activity | GO:0043405 | 108 | 0.531 | |
| phospholipase c activating dopamine receptor signaling pathway | GO:0060158 | 2 | 0.529 | |
| regulation of protein serine threonine kinase activity | GO:0071900 | 179 | 0.526 | |
| angiogenesis | GO:0001525 | 147 | 0.520 | Mouse |
| regulation of vesicle mediated transport | GO:0060627 | 130 | 0.515 | Rat |
| positive regulation of kinase activity | GO:0033674 | 204 | 0.514 | |
| behavior | GO:0007610 | 112 | 0.513 | Mouse Rat Worm |
| purine ribonucleotide biosynthetic process | GO:0009152 | 79 | 0.512 | |
| regulation of ion transport | GO:0043269 | 189 | 0.510 | |
| cellular chemical homeostasis | GO:0055082 | 180 | 0.508 | |
| anatomical structure formation involved in morphogenesis | GO:0048646 | 284 | 0.497 | Mouse |
| positive regulation of jnk cascade | GO:0046330 | 52 | 0.493 | |
| negative regulation of programmed cell death | GO:0043069 | 321 | 0.493 | Mouse |
| negative regulation of protein metabolic process | GO:0051248 | 391 | 0.482 | |
| positive regulation of cellular amino acid metabolic process | GO:0045764 | 3 | 0.480 | |
| regulation of protein transport | GO:0051223 | 213 | 0.471 | Worm |
| single organism cellular localization | GO:1902580 | 332 | 0.467 | Mouse Worm |
| transmembrane receptor protein serine threonine kinase signaling pathway | GO:0007178 | 125 | 0.464 | |
| regulation of protein modification by small protein conjugation or removal | GO:1903320 | 107 | 0.464 | |
| response to organic cyclic compound | GO:0014070 | 204 | 0.463 | Rat |
| wound healing | GO:0042060 | 115 | 0.459 | |
| positive regulation of stress activated mapk cascade | GO:0032874 | 60 | 0.458 | |
| endothelial cell proliferation | GO:0001935 | 65 | 0.455 | |
| positive regulation of calcium ion transport into cytosol | GO:0010524 | 20 | 0.453 | |
| positive regulation of endothelial cell proliferation | GO:0001938 | 37 | 0.446 | |
| peptidyl tyrosine modification | GO:0018212 | 170 | 0.442 | |
| positive regulation of proteolysis | GO:0045862 | 142 | 0.439 | |
| sodium ion homeostasis | GO:0055078 | 14 | 0.439 | |
| erk1 and erk2 cascade | GO:0070371 | 104 | 0.434 | |
| regulation of erk1 and erk2 cascade | GO:0070372 | 99 | 0.432 | |
| regulation of sensory perception of pain | GO:0051930 | 3 | 0.428 | |
| renal system process | GO:0003014 | 25 | 0.428 | |
| purine nucleotide biosynthetic process | GO:0006164 | 84 | 0.427 | |
| positive regulation of cytoplasmic transport | GO:1903651 | 82 | 0.418 | |
| positive regulation of cellular amine metabolic process | GO:0033240 | 7 | 0.413 | |
| stress activated protein kinase signaling cascade | GO:0031098 | 94 | 0.411 | |
| cellular protein catabolic process | GO:0044257 | 261 | 0.411 | |
| positive regulation of map kinase activity | GO:0043406 | 80 | 0.410 | |
| cell cell signaling | GO:0007267 | 155 | 0.407 | Mouse Rat |
| regulation of intrinsic apoptotic signaling pathway | GO:2001242 | 72 | 0.406 | |
| response to organonitrogen compound | GO:0010243 | 156 | 0.404 | Rat Fly |
| ribonucleotide biosynthetic process | GO:0009260 | 81 | 0.396 | |
| second messenger mediated signaling | GO:0019932 | 78 | 0.392 | |
| regulation of epithelial cell proliferation | GO:0050678 | 113 | 0.391 | Mouse |
| regulation of peptidase activity | GO:0052547 | 180 | 0.390 | |
| negative regulation of sodium ion transmembrane transporter activity | GO:2000650 | 2 | 0.390 | |
| cell development | GO:0048468 | 328 | 0.382 | Zebrafish Mouse Rat Fly |
| parturition | GO:0007567 | 1 | 0.382 | |
| circulatory system development | GO:0072359 | 262 | 0.381 | Zebrafish Mouse |
| multicellular organismal homeostasis | GO:0048871 | 67 | 0.381 | |
| positive regulation of cytosolic calcium ion concentration involved in phospholipase c activating g protein coupled signaling pathway | GO:0051482 | 6 | 0.380 | |
| muscle structure development | GO:0061061 | 98 | 0.377 | Fly |
| response to hormone | GO:0009725 | 175 | 0.373 | Rat Fly |
| adenylate cyclase activating g protein coupled receptor signaling pathway | GO:0007189 | 18 | 0.370 | |
| lymphocyte activation | GO:0046649 | 133 | 0.369 | |
| positive regulation of cell differentiation | GO:0045597 | 211 | 0.367 | |
| nucleoside phosphate biosynthetic process | GO:1901293 | 109 | 0.361 | |
| positive regulation of calcium ion transport | GO:0051928 | 51 | 0.360 | |
| blood vessel development | GO:0001568 | 172 | 0.360 | Zebrafish Mouse |
| organ morphogenesis | GO:0009887 | 147 | 0.359 | Mouse Fly |
| cellular ion homeostasis | GO:0006873 | 168 | 0.358 | |
| regulation of lipid metabolic process | GO:0019216 | 96 | 0.357 | |
| positive regulation of multicellular organismal metabolic process | GO:0044253 | 11 | 0.353 | |
| regulation of proteasomal protein catabolic process | GO:0061136 | 87 | 0.353 | |
| regulation of coagulation | GO:0050818 | 44 | 0.351 | |
| regulation of blood coagulation | GO:0030193 | 42 | 0.350 | |
| neurological system process | GO:0050877 | 163 | 0.348 | Mouse Rat Worm |
| negative regulation of protein modification process | GO:0031400 | 200 | 0.348 | |
| segmentation | GO:0035282 | 4 | 0.347 | |
| regulation of multicellular organismal metabolic process | GO:0044246 | 17 | 0.342 | |
| regulation of jnk cascade | GO:0046328 | 73 | 0.342 | |
| regulation of cell migration | GO:0030334 | 289 | 0.340 | |
| regulation of leukocyte activation | GO:0002694 | 115 | 0.340 | |
| regulation of cysteine type endopeptidase activity | GO:2000116 | 127 | 0.336 | |
| negative regulation of cellular amine metabolic process | GO:0033239 | 3 | 0.336 | |
| small gtpase mediated signal transduction | GO:0007264 | 78 | 0.335 | |
| epithelium development | GO:0060429 | 227 | 0.334 | Zebrafish Fly |
| regulation of nuclear division | GO:0051783 | 65 | 0.334 | |
| cyclic nucleotide biosynthetic process | GO:0009190 | 61 | 0.333 | |
| endocytosis | GO:0006897 | 159 | 0.328 | Rat |
| cytokine production | GO:0001816 | 247 | 0.327 | |
| positive regulation of phospholipase activity | GO:0010518 | 22 | 0.326 | |
| regulation of behavior | GO:0050795 | 82 | 0.318 | Worm |
| intrinsic apoptotic signaling pathway | GO:0097193 | 127 | 0.317 | |
| negative regulation of cellular protein metabolic process | GO:0032269 | 353 | 0.313 | |
| regulation of binding | GO:0051098 | 111 | 0.312 | |
| regulation of mitosis | GO:0007088 | 63 | 0.310 | |
| jnk cascade | GO:0007254 | 80 | 0.306 | |
| transforming growth factor beta receptor signaling pathway | GO:0007179 | 76 | 0.302 | |
| response to oxygen levels | GO:0070482 | 100 | 0.302 | |
| regulation of cellular response to stress | GO:0080135 | 244 | 0.300 | Fly |
| positive regulation of stress activated protein kinase signaling cascade | GO:0070304 | 61 | 0.298 | |
| maintenance of location | GO:0051235 | 112 | 0.294 | Fly |
| negative regulation of intracellular signal transduction | GO:1902532 | 183 | 0.294 | |
| response to hyperoxia | GO:0055093 | 4 | 0.293 | |
| anatomical structure homeostasis | GO:0060249 | 100 | 0.293 | |
| oogenesis | GO:0048477 | 2 | 0.289 | |
| amide transport | GO:0042886 | 76 | 0.288 | |
| regulation of cell cycle process | GO:0010564 | 266 | 0.286 | |
| response to growth factor | GO:0070848 | 205 | 0.286 | |
| positive regulation of vasoconstriction | GO:0045907 | 3 | 0.281 | |
| post embryonic development | GO:0009791 | 2 | 0.281 | Worm Fly |
| regulation of defense response | GO:0031347 | 154 | 0.279 | |
| regulation of endocytosis | GO:0030100 | 72 | 0.278 | Rat |
| positive regulation of phosphatidylinositol biosynthetic process | GO:0010513 | 3 | 0.275 | |
| negative regulation of developmental process | GO:0051093 | 247 | 0.274 | Mouse Fly |
| protein maturation | GO:0051604 | 233 | 0.267 | |
| cellular response to growth factor stimulus | GO:0071363 | 197 | 0.266 | |
| regulation of ion homeostasis | GO:2000021 | 73 | 0.265 | |
| cytosolic calcium ion homeostasis | GO:0051480 | 89 | 0.265 | |
| positive regulation of phosphoprotein phosphatase activity | GO:0032516 | 9 | 0.263 | |
| lipid biosynthetic process | GO:0008610 | 177 | 0.261 | |
| regulation of cyclic nucleotide metabolic process | GO:0030799 | 63 | 0.257 | |
| divalent inorganic cation transport | GO:0072511 | 158 | 0.256 | |
| reactive oxygen species metabolic process | GO:0072593 | 75 | 0.253 | |
| detection of mechanical stimulus | GO:0050982 | 4 | 0.252 | |
| peptide transport | GO:0015833 | 74 | 0.250 | |
| phospholipase c activating adrenergic receptor signaling pathway | GO:0071882 | 1 | 0.250 | |
| response to increased oxygen levels | GO:0036296 | 4 | 0.249 | |
| cell division | GO:0051301 | 168 | 0.248 | |
| caveola assembly | GO:0070836 | 4 | 0.247 | |
| phosphatidylinositol 3 kinase signaling | GO:0014065 | 48 | 0.245 | |
| response to metal ion | GO:0010038 | 84 | 0.242 | Rat |
| vascular process in circulatory system | GO:0003018 | 29 | 0.240 | |
| positive regulation of leukocyte activation | GO:0002696 | 80 | 0.239 | |
| lipid transport | GO:0006869 | 90 | 0.237 | |
| cardiovascular system development | GO:0072358 | 262 | 0.236 | Zebrafish Mouse |
| regulation of establishment of protein localization | GO:0070201 | 242 | 0.234 | Worm |
| somatic stem cell division | GO:0048103 | 1 | 0.234 | |
| sensory perception | GO:0007600 | 103 | 0.233 | |
| divalent metal ion transport | GO:0070838 | 152 | 0.230 | |
| sensory perception of mechanical stimulus | GO:0050954 | 37 | 0.228 | |
| cyclic purine nucleotide metabolic process | GO:0052652 | 60 | 0.227 | |
| negative regulation of cellular amino acid metabolic process | GO:0045763 | 2 | 0.223 | |
| purine containing compound biosynthetic process | GO:0072522 | 88 | 0.221 | |
| plasma membrane raft assembly | GO:0044854 | 4 | 0.221 | |
| regulation of secretion | GO:0051046 | 194 | 0.219 | |
| positive regulation of blood circulation | GO:1903524 | 12 | 0.218 | |
| regulation of cell activation | GO:0050865 | 125 | 0.217 | |
| neurogenesis | GO:0022008 | 169 | 0.217 | Mouse Rat Fly |
| negative regulation of jak stat cascade | GO:0046426 | 4 | 0.216 | |
| nervous system development | GO:0007399 | 293 | 0.214 | Mouse Rat Fly |
| negative regulation of nucleotide biosynthetic process | GO:0030809 | 11 | 0.211 | |
| activation of mapk activity | GO:0000187 | 45 | 0.211 | |
| regulation of receptor mediated endocytosis | GO:0048259 | 32 | 0.207 | |
| regulation of reactive oxygen species metabolic process | GO:2000377 | 41 | 0.203 | |
| response to steroid hormone | GO:0048545 | 80 | 0.202 | Rat |
| regulation of vasculature development | GO:1901342 | 97 | 0.201 | |
| positive regulation of metalloenzyme activity | GO:0048554 | 2 | 0.201 | |
| regulation of protein binding | GO:0043393 | 66 | 0.201 | |
| positive regulation of protein serine threonine kinase activity | GO:0071902 | 119 | 0.200 | |
| negative regulation of catalytic activity | GO:0043086 | 335 | 0.200 | |
| negative regulation of phosphorylation | GO:0042326 | 174 | 0.199 | |
| regulation of cell adhesion | GO:0030155 | 166 | 0.198 | |
| regulation of cytokine production | GO:0001817 | 232 | 0.196 | |
| cellular response to oxygen levels | GO:0071453 | 55 | 0.195 | |
| inositol lipid mediated signaling | GO:0048017 | 55 | 0.194 | |
| serotonin receptor signaling pathway | GO:0007210 | 11 | 0.193 | |
| regeneration | GO:0031099 | 4 | 0.191 | Fly |
| regulation of cyclic nucleotide biosynthetic process | GO:0030802 | 49 | 0.191 | |
| eye development | GO:0001654 | 42 | 0.191 | Fly |
| regulation of ras protein signal transduction | GO:0046578 | 155 | 0.190 | |
| regulation of purine nucleotide metabolic process | GO:1900542 | 264 | 0.190 | |
| peptidyl tyrosine phosphorylation | GO:0018108 | 170 | 0.190 | |
| receptor internalization involved in canonical wnt signaling pathway | GO:2000286 | 3 | 0.189 | |
| hormone secretion | GO:0046879 | 65 | 0.188 | |
| negative regulation of binding | GO:0051100 | 57 | 0.186 | |
| negative regulation of protein phosphorylation | GO:0001933 | 140 | 0.185 | |
| cellular response to external stimulus | GO:0071496 | 111 | 0.184 | |
| immune effector process | GO:0002252 | 159 | 0.183 | Zebrafish Fly |
| regulation of dephosphorylation | GO:0035303 | 96 | 0.183 | |
| renal response to blood flow involved in circulatory renin angiotensin regulation of systemic arterial blood pressure | GO:0001999 | 1 | 0.183 | |
| regulation of cell differentiation | GO:0045595 | 393 | 0.182 | Mouse Fly |
| regulation of response to external stimulus | GO:0032101 | 222 | 0.182 | Mouse Worm Fly |
| anterior posterior axis specification | GO:0009948 | 2 | 0.180 | |
| proteasomal protein catabolic process | GO:0010498 | 176 | 0.179 | |
| regulation of cellular component biogenesis | GO:0044087 | 281 | 0.178 | |
| positive regulation of jun kinase activity | GO:0043507 | 23 | 0.176 | |
| locomotory behavior | GO:0007626 | 1 | 0.176 | Mouse |
| single organism behavior | GO:0044708 | 28 | 0.175 | Mouse Rat Worm |
| regulation of secretion by cell | GO:1903530 | 177 | 0.174 | |
| response to drug | GO:0042493 | 81 | 0.174 | Rat |
| cytoplasmic transport | GO:0016482 | 379 | 0.172 | Worm |
| reproductive process | GO:0022414 | 106 | 0.172 | Mouse |
| blastoderm segmentation | GO:0007350 | 2 | 0.169 | |
| regulation of lymphocyte activation | GO:0051249 | 103 | 0.168 | |
| regulation of protein processing | GO:0070613 | 150 | 0.168 | |
| regulation of response to wounding | GO:1903034 | 101 | 0.167 | Fly |
| regulation of cell morphogenesis | GO:0022604 | 153 | 0.166 | Mouse Fly |
| regulation of purine nucleotide biosynthetic process | GO:1900371 | 50 | 0.166 | |
| negative regulation of protein binding | GO:0032091 | 35 | 0.165 | |
| t cell activation | GO:0042110 | 99 | 0.163 | |
| protein import | GO:0017038 | 130 | 0.161 | Worm |
| protein kinase b signaling | GO:0043491 | 69 | 0.160 | |
| positive regulation of protein transport | GO:0051222 | 135 | 0.160 | |
| regulation of t cell activation | GO:0050863 | 77 | 0.159 | |
| response to cytokine | GO:0034097 | 232 | 0.159 | |
| negative regulation of nitric oxide biosynthetic process | GO:0045019 | 5 | 0.159 | |
| receptor mediated endocytosis | GO:0006898 | 84 | 0.157 | |
| positive regulation of endocytosis | GO:0045807 | 42 | 0.157 | |
| negative regulation of cyclic nucleotide biosynthetic process | GO:0030803 | 10 | 0.156 | |
| oxidation reduction process | GO:0055114 | 396 | 0.156 | |
| negative regulation of pinocytosis | GO:0048550 | 4 | 0.156 | |
| blood circulation | GO:0008015 | 113 | 0.154 | |
| multicellular organismal metabolic process | GO:0044236 | 34 | 0.153 | |
| cellular response to transforming growth factor beta stimulus | GO:0071560 | 94 | 0.152 | |
| response to external biotic stimulus | GO:0043207 | 261 | 0.151 | |
| membrane organization | GO:0061024 | 292 | 0.151 | Mouse |
| carbohydrate derivative biosynthetic process | GO:1901137 | 207 | 0.150 | |
| g protein coupled receptor signaling pathway | GO:0007186 | 207 | 0.149 | |
| regulation of the force of heart contraction by chemical signal | GO:0003057 | 1 | 0.149 | |
| rho protein signal transduction | GO:0007266 | 26 | 0.148 | |
| proteolysis involved in cellular protein catabolic process | GO:0051603 | 244 | 0.147 | |
| protein catabolic process | GO:0030163 | 325 | 0.145 | |
| regulation of protein secretion | GO:0050708 | 86 | 0.145 | |
| negative regulation of response to external stimulus | GO:0032102 | 83 | 0.143 | Mouse Fly |
| regulation of vascular endothelial growth factor receptor signaling pathway | GO:0030947 | 9 | 0.141 | |
| regulation of neurogenesis | GO:0050767 | 82 | 0.140 | Mouse Fly |
| cell morphogenesis | GO:0000902 | 296 | 0.140 | Mouse Fly |
| single organism nuclear import | GO:1902593 | 104 | 0.140 | Worm |
| stress activated mapk cascade | GO:0051403 | 93 | 0.139 | |
| neuromuscular junction development | GO:0007528 | 3 | 0.139 | |
| neuron death | GO:0070997 | 65 | 0.138 | |
| positive regulation of secretion | GO:0051047 | 116 | 0.138 | |
| potassium ion transport | GO:0006813 | 62 | 0.138 | |
| immune response | GO:0006955 | 307 | 0.137 | Zebrafish Fly |
| positive regulation of intrinsic apoptotic signaling pathway | GO:2001244 | 28 | 0.136 | |
| negative regulation of epithelial cell proliferation | GO:0050680 | 48 | 0.136 | Mouse |
| positive regulation of reactive oxygen species metabolic process | GO:2000379 | 24 | 0.136 | |
| response to monosaccharide | GO:0034284 | 20 | 0.135 | Rat |
| mitotic cell cycle | GO:0000278 | 326 | 0.134 | |
| regulation of angiogenesis | GO:0045765 | 92 | 0.134 | |
| regulation of phosphatase activity | GO:0010921 | 81 | 0.133 | |
| activation of cysteine type endopeptidase activity | GO:0097202 | 57 | 0.132 | |
| response to inorganic substance | GO:0010035 | 127 | 0.132 | Rat |
| anion transport | GO:0006820 | 161 | 0.131 | |
| cellular metal ion homeostasis | GO:0006875 | 146 | 0.131 | |
| negative regulation of cell adhesion | GO:0007162 | 64 | 0.130 | |
| organic hydroxy compound biosynthetic process | GO:1901617 | 71 | 0.129 | |
| negative regulation of growth | GO:0045926 | 97 | 0.129 | Mouse Fly |
| regulation of stress activated protein kinase signaling cascade | GO:0070302 | 85 | 0.128 | |
| cholesterol transport | GO:0030301 | 39 | 0.128 | |
| positive regulation of vasodilation | GO:0045909 | 4 | 0.127 | |
| intracellular protein transport | GO:0006886 | 270 | 0.127 | Worm |
| regulation of nucleotide metabolic process | GO:0006140 | 269 | 0.127 | |
| negative regulation of reactive oxygen species biosynthetic process | GO:1903427 | 1 | 0.126 | |
| regulation of vasodilation | GO:0042312 | 4 | 0.125 | |
| rostrocaudal neural tube patterning | GO:0021903 | 1 | 0.125 | |
| negative regulation of multicellular organismal process | GO:0051241 | 317 | 0.125 | Mouse Fly |
| cellular response to nutrient levels | GO:0031669 | 69 | 0.124 | |
| regulation of peptidyl tyrosine phosphorylation | GO:0050730 | 108 | 0.124 | |
| negative regulation of sodium ion transport | GO:0010766 | 3 | 0.124 | |
| negative regulation of tyrosine phosphorylation of stat protein | GO:0042532 | 2 | 0.124 | |
| organophosphate biosynthetic process | GO:0090407 | 163 | 0.122 | |
| calcium mediated signaling | GO:0019722 | 44 | 0.121 | |
| negative regulation of cytokine mediated signaling pathway | GO:0001960 | 22 | 0.118 | |
| regulation of anatomical structure size | GO:0090066 | 101 | 0.118 | Mouse Fly |
| cellular response to hyperoxia | GO:0071455 | 4 | 0.117 | |
| regulation of camp metabolic process | GO:0030814 | 52 | 0.117 | |
| regulation of synaptic plasticity | GO:0048167 | 3 | 0.117 | Mouse Rat |
| amino acid transport | GO:0006865 | 28 | 0.117 | |
| negative regulation of transcription from rna polymerase ii promoter | GO:0000122 | 281 | 0.115 | |
| positive regulation of cell cycle | GO:0045787 | 140 | 0.115 | |
| regulation of oxidoreductase activity | GO:0051341 | 43 | 0.115 | |
| regulation of pinocytosis | GO:0048548 | 6 | 0.115 | |
| gland development | GO:0048732 | 48 | 0.114 | Mouse Fly |
| jak stat cascade | GO:0007259 | 46 | 0.114 | |
| positive regulation of homeostatic process | GO:0032846 | 47 | 0.114 | |
| regulation of cell division | GO:0051302 | 116 | 0.114 | |
| positive regulation of cell activation | GO:0050867 | 81 | 0.114 | |
| cell activation | GO:0001775 | 213 | 0.114 | Zebrafish |
| positive regulation of cell development | GO:0010720 | 92 | 0.113 | |
| negative regulation of proteolysis | GO:0045861 | 132 | 0.113 | |
| mitotic sister chromatid separation | GO:0051306 | 18 | 0.113 | |
| protein localization to organelle | GO:0033365 | 280 | 0.112 | Worm |
| regulation of body fluid levels | GO:0050878 | 99 | 0.112 | |
| signal release | GO:0023061 | 70 | 0.112 | |
| positive regulation of release of sequestered calcium ion into cytosol | GO:0051281 | 16 | 0.111 | |
| inner ear morphogenesis | GO:0042472 | 4 | 0.111 | |
| regulation of neuron differentiation | GO:0045664 | 70 | 0.110 | Mouse Fly |
| somitogenesis | GO:0001756 | 2 | 0.110 | |
| regulation of nucleocytoplasmic transport | GO:0046822 | 98 | 0.109 | Worm |
| neural tube patterning | GO:0021532 | 2 | 0.109 | |
| tyrosine phosphorylation of stat protein | GO:0007260 | 33 | 0.109 | |
| response to acid chemical | GO:0001101 | 66 | 0.109 | |
| mitochondrion organization | GO:0007005 | 156 | 0.109 | |
| rna processing | GO:0006396 | 255 | 0.108 | |
| renal sodium ion transport | GO:0003096 | 2 | 0.108 | |
| cellular response to starvation | GO:0009267 | 58 | 0.107 | |
| positive regulation of nucleotide catabolic process | GO:0030813 | 185 | 0.107 | |
| caveolin mediated endocytosis | GO:0072584 | 4 | 0.107 | |
| cellular component morphogenesis | GO:0032989 | 314 | 0.107 | Mouse Fly |
| bmp signaling pathway | GO:0030509 | 49 | 0.106 | |
| regulation of wnt signaling pathway | GO:0030111 | 123 | 0.106 | |
| response to biotic stimulus | GO:0009607 | 276 | 0.106 | |
| regulation of sensory perception | GO:0051931 | 3 | 0.106 | |
| response to wounding | GO:0009611 | 168 | 0.106 | Fly |
| negative regulation of cell proliferation | GO:0008285 | 228 | 0.105 | |
| embryo development | GO:0009790 | 123 | 0.105 | Zebrafish |
| striated muscle tissue development | GO:0014706 | 59 | 0.105 | Mouse |
| hematopoietic or lymphoid organ development | GO:0048534 | 186 | 0.104 | Zebrafish |
| response to mechanical stimulus | GO:0009612 | 51 | 0.104 | |
| spinal cord development | GO:0021510 | 4 | 0.103 | |
| positive regulation of cytosolic calcium ion concentration | GO:0007204 | 82 | 0.103 | |
| divalent inorganic cation homeostasis | GO:0072507 | 136 | 0.102 | |
| response to transforming growth factor beta | GO:0071559 | 94 | 0.102 | |
| morphogenesis of embryonic epithelium | GO:0016331 | 4 | 0.102 | |
| autophagy | GO:0006914 | 88 | 0.102 | Fly |
| positive regulation of lipid biosynthetic process | GO:0046889 | 22 | 0.101 | |
| positive regulation of cysteine type endopeptidase activity | GO:2001056 | 79 | 0.101 | |
| regulation of jun kinase activity | GO:0043506 | 27 | 0.101 | |
| i kappab kinase nf kappab signaling | GO:0007249 | 166 | 0.100 | |
| calcium ion transport | GO:0006816 | 147 | 0.099 | |
| negative regulation of protein maturation | GO:1903318 | 142 | 0.099 | |
| endosomal transport | GO:0016197 | 129 | 0.099 | |
| tissue homeostasis | GO:0001894 | 63 | 0.099 | |
| positive regulation of lipid metabolic process | GO:0045834 | 50 | 0.099 | |
| tube development | GO:0035295 | 125 | 0.099 | Zebrafish |
| digestive system development | GO:0055123 | 75 | 0.099 | Zebrafish |
| negative regulation of lyase activity | GO:0051350 | 7 | 0.098 | |
| intestinal cholesterol absorption | GO:0030299 | 4 | 0.097 | |
| positive regulation of ras gtpase activity | GO:0032320 | 117 | 0.097 | |
| cgmp metabolic process | GO:0046068 | 19 | 0.096 | |
| regulation of cgmp biosynthetic process | GO:0030826 | 4 | 0.096 | |
| response to extracellular stimulus | GO:0009991 | 85 | 0.096 | Rat Fly |
| peptidyl serine phosphorylation | GO:0018105 | 101 | 0.096 | |
| positive regulation of secretion by cell | GO:1903532 | 108 | 0.096 | |
| positive regulation of intracellular transport | GO:0032388 | 104 | 0.096 | |
| response to alcohol | GO:0097305 | 64 | 0.096 | Rat |
| calcium ion transport into cytosol | GO:0060402 | 48 | 0.096 | |
| regulation of hormone levels | GO:0010817 | 125 | 0.096 | |
| cellular response to acid chemical | GO:0071229 | 44 | 0.095 | |
| s shaped body morphogenesis | GO:0072050 | 4 | 0.094 | |
| epithelial cell differentiation | GO:0030855 | 141 | 0.094 | |
| epithelial cell development | GO:0002064 | 34 | 0.093 | |
| positive regulation of epithelial cell proliferation | GO:0050679 | 65 | 0.092 | |
| positive regulation of protein catabolic process | GO:0045732 | 75 | 0.092 | |
| regulation of innate immune response | GO:0045088 | 97 | 0.091 | |
| regulation of mitotic sister chromatid separation | GO:0010965 | 27 | 0.091 | |
| organic hydroxy compound metabolic process | GO:1901615 | 147 | 0.091 | |
| nucleocytoplasmic transport | GO:0006913 | 176 | 0.091 | Worm |
| hormone transport | GO:0009914 | 68 | 0.090 | |
| regulation of protein ubiquitination | GO:0031396 | 95 | 0.090 | |
| cellular response to organonitrogen compound | GO:0071417 | 124 | 0.090 | Fly |
| vasodilation | GO:0042311 | 4 | 0.090 | |
| neuron differentiation | GO:0030182 | 138 | 0.089 | Mouse Rat Fly |
| protein processing | GO:0016485 | 226 | 0.089 | |
| regulation of locomotion | GO:0040012 | 329 | 0.089 | |
| vasculature development | GO:0001944 | 181 | 0.089 | Zebrafish Mouse |
| cellular response to abiotic stimulus | GO:0071214 | 117 | 0.089 | |
| positive regulation of neurogenesis | GO:0050769 | 49 | 0.088 | |
| positive regulation of lipase activity | GO:0060193 | 28 | 0.088 | |
| regulation of membrane potential | GO:0042391 | 95 | 0.088 | Mouse |
| single organism reproductive process | GO:0044702 | 98 | 0.086 | Mouse |
| negative regulation of cgmp metabolic process | GO:0030824 | 1 | 0.086 | |
| regulation of endothelial cell proliferation | GO:0001936 | 56 | 0.085 | |
| developmental maturation | GO:0021700 | 28 | 0.085 | Mouse Fly |
| plasma membrane raft organization | GO:0044857 | 4 | 0.085 | |
| cyclic nucleotide mediated signaling | GO:0019935 | 26 | 0.085 | |
| mesenchyme development | GO:0060485 | 59 | 0.085 | |
| carbohydrate homeostasis | GO:0033500 | 31 | 0.084 | |
| protein k11 linked ubiquitination | GO:0070979 | 24 | 0.084 | |
| epidermal growth factor activated receptor transactivation by g protein coupled receptor signaling pathway | GO:0035625 | 4 | 0.084 | |
| regulation of i kappab kinase nf kappab signaling | GO:0043122 | 162 | 0.084 | |
| positive regulation of nucleotide metabolic process | GO:0045981 | 230 | 0.083 | |
| cytosolic calcium ion transport | GO:0060401 | 48 | 0.083 | |
| negative regulation of transforming growth factor beta receptor signaling pathway | GO:0030512 | 28 | 0.082 | |
| positive regulation of nucleoside metabolic process | GO:0045979 | 186 | 0.082 | |
| positive regulation of gtpase activity | GO:0043547 | 166 | 0.082 | |
| protein homooligomerization | GO:0051260 | 100 | 0.082 | |
| muscle cell differentiation | GO:0042692 | 63 | 0.082 | |
| regulation of endopeptidase activity | GO:0052548 | 170 | 0.082 | |
| regulation of sister chromatid segregation | GO:0033045 | 27 | 0.081 | |
| organelle fission | GO:0048285 | 149 | 0.081 | |
| regulation of cell cell adhesion | GO:0022407 | 57 | 0.081 | |
| transmembrane receptor protein tyrosine kinase signaling pathway | GO:0007169 | 181 | 0.080 | Rat Fly |
| protein polyubiquitination | GO:0000209 | 110 | 0.080 | |
| digestive tract morphogenesis | GO:0048546 | 56 | 0.080 | Zebrafish |
| regulation of metalloenzyme activity | GO:0048552 | 3 | 0.079 | |
| central nervous system development | GO:0007417 | 123 | 0.079 | Mouse |
| cellular response to extracellular stimulus | GO:0031668 | 72 | 0.079 | |
| regulation of transforming growth factor beta receptor signaling pathway | GO:0017015 | 48 | 0.079 | |
| detection of stimulus involved in sensory perception | GO:0050906 | 43 | 0.079 | |
| skeletal system morphogenesis | GO:0048705 | 24 | 0.078 | |
| regulation of muscle system process | GO:0090257 | 53 | 0.078 | |
| regulation of cytoplasmic transport | GO:1903649 | 149 | 0.078 | Worm |
| oocyte differentiation | GO:0009994 | 2 | 0.078 | |
| extrinsic apoptotic signaling pathway | GO:0097191 | 119 | 0.077 | |
| muscle cell development | GO:0055001 | 29 | 0.077 | |
| cellular response to cytokine stimulus | GO:0071345 | 181 | 0.076 | |
| regulation of dopamine receptor signaling pathway | GO:0060159 | 3 | 0.076 | |
| organophosphate catabolic process | GO:0046434 | 430 | 0.076 | |
| positive regulation of immune system process | GO:0002684 | 283 | 0.076 | |
| muscle tissue development | GO:0060537 | 62 | 0.075 | Mouse |
