Homo sapiens

233 known processes

ROBO1

roundabout, axon guidance receptor, homolog 1 (Drosophila)

(Aliases: MGC133277,MGC131599,FLJ21882,SAX3,DUTT1)

ROBO1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
post embryonic developmentGO:000979120.124
regulation of cell differentiationGO:00455953930.098
negative regulation of multicellular organismal processGO:00512413170.092
ras protein signal transductionGO:0007265730.086
cellular amino acid metabolic processGO:00065201160.081
system processGO:00030083490.077
Fly
cell developmentGO:00484683280.073
cellular amine metabolic processGO:0044106410.070
cardiovascular system developmentGO:00723582620.070
small gtpase mediated signal transductionGO:0007264780.068
cell adhesionGO:00071553250.067
regulation of cellular amine metabolic processGO:0033238110.066
regulation of cell migrationGO:00303342890.066
Fly
regulation of cellular component movementGO:00512703340.063
Fly
cell projection organizationGO:00300302520.063
cellular ketone metabolic processGO:0042180800.060
circulatory system developmentGO:00723592620.060
regulation of cellular ketone metabolic processGO:0010565500.060
regulation of locomotionGO:00400123290.060
regulation of cell motilityGO:20001452990.058
Fly
positive regulation of cellular amino acid metabolic processGO:004576430.058
amine metabolic processGO:0009308440.058
biological adhesionGO:00226103310.057
positive regulation of developmental processGO:00510943140.057
response to oxygen containing compoundGO:19017003690.056
regulation of anatomical structure morphogenesisGO:00226032860.055
cellular component morphogenesisGO:00329893140.055
anatomical structure formation involved in morphogenesisGO:00486462840.054
cell morphogenesisGO:00009022960.054
organ formationGO:004864530.054
Zebrafish Fly
spinal cord developmentGO:002151040.053
Rat
multicellular organismal agingGO:001025930.053
determination of adult lifespanGO:000834020.053
regulation of cellular amino acid metabolic processGO:000652160.053
cellular response to endogenous stimulusGO:00714953360.053
Human
nervous system developmentGO:00073992930.052
positive regulation of cellular amine metabolic processGO:003324070.051
enzyme linked receptor protein signaling pathwayGO:00071673030.049
positive regulation of cellular component organizationGO:00511303760.048
rho protein signal transductionGO:0007266260.047
segmentationGO:003528240.047
response to abiotic stimulusGO:00096283360.046
ribonucleoside catabolic processGO:00424544060.046
nucleoside catabolic processGO:00091644080.046
nucleoside phosphate catabolic processGO:19012924120.045
nucleoside triphosphate metabolic processGO:00091414220.045
epithelium developmentGO:00604292270.044
locomotory behaviorGO:000762610.044
Fly
regenerationGO:003109940.044
positive regulation of transportGO:00510503360.044
purine ribonucleoside metabolic processGO:00461284370.043
organophosphate catabolic processGO:00464344300.043
purine ribonucleotide catabolic processGO:00091544040.042
response to cytokineGO:00340972320.042
negative regulation of developmental processGO:00510932470.042
immune responseGO:00069553070.042
purine nucleotide catabolic processGO:00061954050.042
ribonucleoside triphosphate catabolic processGO:00092033910.041
protein localization to organelleGO:00333652800.041
neurological system processGO:00508771630.041
Fly
glycosyl compound catabolic processGO:19016584130.041
cytoplasmic transportGO:00164823790.041
purine containing compound catabolic processGO:00725234110.041
positive regulation of phosphorylationGO:00423273940.041
female gamete generationGO:000729220.040
single organism cell adhesionGO:00986021790.040
Fly
ameboidal type cell migrationGO:00016671350.040
chemotaxisGO:00069351570.040
neurogenesisGO:00220081690.040
neuron projection developmentGO:00311751060.039
neuron differentiationGO:00301821380.039
ribonucleotide catabolic processGO:00092614050.039
negative regulation of axon extensionGO:003051720.039
blood vessel morphogenesisGO:00485141620.038
oogenesisGO:004847720.038
purine ribonucleoside catabolic processGO:00461303980.038
cellular response to oxygen containing compoundGO:19017012760.038
purine ribonucleoside triphosphate metabolic processGO:00092054110.038
ribonucleoside triphosphate metabolic processGO:00091994120.038
positive regulation of cell differentiationGO:00455972110.038
purine nucleoside triphosphate catabolic processGO:00091463920.037
vasculature developmentGO:00019441810.037
positive regulation of locomotionGO:00400171860.037
cation transportGO:00068123310.037
purine nucleoside triphosphate metabolic processGO:00091444120.036
single organismal cell cell adhesionGO:00163371480.036
Fly
regulation of axon guidanceGO:190266730.036
membrane organizationGO:00610242920.036
ion homeostasisGO:00508012300.036
maintenance of locationGO:00512351120.036
response to growth factorGO:00708482050.036
chemical homeostasisGO:00488783060.035
regulation of cell developmentGO:00602841610.035
cellular response to growth factor stimulusGO:00713631970.035
regulation of axon extension involved in axon guidanceGO:004884120.035
generation of neuronsGO:00486991520.034
negative regulation of cell differentiationGO:00455961710.034
taxisGO:00423301570.034
regulation of nucleotide metabolic processGO:00061402690.034
cellular homeostasisGO:00197251960.034
Fly
purine nucleoside catabolic processGO:00061523980.034
signal transduction by phosphorylationGO:00230142970.034
nucleotide catabolic processGO:00091664080.034
motor neuron axon guidanceGO:000804520.034
Fly
cell fate determinationGO:000170930.034
actin filament based processGO:00300292240.034
negative regulation of cell proliferationGO:00082852280.033
regulation of cell cycleGO:00517263930.033
single organism membrane organizationGO:00448022680.033
purine ribonucleoside triphosphate catabolic processGO:00092073910.033
regulation of cellular component biogenesisGO:00440872810.033
regulation of kinase activityGO:00435493140.033
organ morphogenesisGO:00098871470.032
Zebrafish Mouse Fly
positive regulation of hydrolase activityGO:00513453310.032
secretionGO:00469032540.032
negative regulation of protein metabolic processGO:00512483910.032
single organism cellular localizationGO:19025803320.032
positive regulation of cell developmentGO:0010720920.032
forebrain generation of neuronsGO:002187230.031
wnt signaling pathwayGO:00160551560.031
mapk cascadeGO:00001652880.031
negative regulation of cellular protein metabolic processGO:00322693530.031
detection of stimulusGO:0051606850.030
regulation of cell projection organizationGO:00313441070.030
nucleoside triphosphate catabolic processGO:00091433940.030
epithelial cell proliferationGO:00506731280.030
cell morphogenesis involved in differentiationGO:00009041440.030
positive regulation of cell motilityGO:20001471770.030
positive regulation of cellular component movementGO:00512721810.030
cellular macromolecular complex assemblyGO:00346223240.030
metal ion transportGO:00300012720.030
vesicle mediated transportGO:00161923710.030
intracellular protein transportGO:00068862700.029
negative regulation of catalytic activityGO:00430863350.029
regulation of cell adhesionGO:00301551660.029
Fly
neuromuscular junction developmentGO:000752830.029
central nervous system developmentGO:00074171230.029
regulation of mapk cascadeGO:00434082620.029
negative regulation of cell deathGO:00605483450.029
cytokine productionGO:00018162470.029
cell projection morphogenesisGO:00488581290.029
lipid metabolic processGO:00066293810.029
regulation of purine nucleotide metabolic processGO:19005422640.029
epithelium migrationGO:00901321190.029
regulation of epithelial cell migrationGO:0010632930.028
Fly
memoryGO:000761330.028
cellular response to dna damage stimulusGO:00069743790.028
regulation of response to external stimulusGO:00321012220.028
negative regulation of cellular component organizationGO:00511292350.028
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.028
forebrain neuron differentiationGO:002187930.027
ion transmembrane transportGO:00342203380.027
associative learningGO:000830610.027
positive regulation of catabolic processGO:00098963100.027
blastoderm segmentationGO:000735020.027
regulation of transferase activityGO:00513383550.027
luteolysisGO:000155430.027
Human
transmembrane transportGO:00550853990.027
dephosphorylationGO:00163112090.027
defense responseGO:00069523150.027
blood vessel developmentGO:00015681720.027
regulation of protein localizationGO:00328802960.027
regulation of protein transportGO:00512232130.027
specification of organ identityGO:001009230.027
guanosine containing compound metabolic processGO:19010682440.027
heart developmentGO:0007507950.027
Zebrafish Fly
positive regulation of cell deathGO:00109422630.026
positive regulation of cell proliferationGO:00082843010.026
response to woundingGO:00096111680.026
mitotic cell cycle processGO:19030472860.026
embryonic epithelial tube formationGO:000183840.026
regulation of immune responseGO:00507762010.026
inner ear morphogenesisGO:004247240.026
stem cell differentiationGO:0048863930.026
Fly
positive regulation of protein phosphorylationGO:00019343130.026
matingGO:000761810.026
cellular chemical homeostasisGO:00550821800.025
morphogenesis of a polarized epitheliumGO:000173830.025
actin cytoskeleton organizationGO:00300362070.025
cell growthGO:00160491600.025
response to biotic stimulusGO:00096072760.025
cation homeostasisGO:00550801890.025
neuron developmentGO:00486661130.025
regulation of cell growthGO:00015581350.025
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781250.025
mitotic cell cycleGO:00002783260.025
hemopoiesisGO:00300971800.024
negative regulation of phosphate metabolic processGO:00459362670.024
endomembrane system organizationGO:00102561960.024
secretion by cellGO:00329402260.024
positive regulation of cell migrationGO:00303351720.024
tube developmentGO:00352951250.024
Human Mouse Fly
gtp metabolic processGO:00460392390.024
morphogenesis of embryonic epitheliumGO:001633140.024
pituitary gland developmentGO:002198320.024
regulation of nucleoside metabolic processGO:00091182090.024
regulation of wnt signaling pathwayGO:00301111230.024
regulation of secretionGO:00510461940.024
regulation of neuron differentiationGO:0045664700.024
positive regulation of mapk cascadeGO:00434101900.023
positive regulation of nucleotide metabolic processGO:00459812300.023
growthGO:00400072020.023
Mouse
hindbrain developmentGO:003090230.023
positive regulation of immune system processGO:00026842830.023
positive regulation of purine nucleotide metabolic processGO:19005442270.023
protein catabolic processGO:00301633250.023
anterior posterior axis specificationGO:000994820.023
response to other organismGO:00517072610.023
photoreceptor cell differentiationGO:004653020.023
midgut developmentGO:000749410.023
regulation of intracellular transportGO:00323861950.023
retinal ganglion cell axon guidanceGO:003129020.023
guanosine containing compound catabolic processGO:19010692390.023
carbohydrate derivative biosynthetic processGO:19011372070.023
cellular lipid metabolic processGO:00442553030.023
organonitrogen compound biosynthetic processGO:19015662000.023
negative regulation of phosphorus metabolic processGO:00105632670.023
regulation of cell cycle processGO:00105642660.023
regulation of proteolysisGO:00301622930.023
negative regulation of programmed cell deathGO:00430693210.023
cellular cation homeostasisGO:00300031630.023
tissue morphogenesisGO:0048729960.022
Zebrafish Mouse
immune system developmentGO:00025201950.022
negative regulation of locomotionGO:00400131180.022
behaviorGO:00076101120.022
negative regulation of apoptotic processGO:00430663160.022
cardiac muscle cell contractionGO:008600340.022
positive regulation of cellular catabolic processGO:00313312840.022
regulation of purine nucleotide catabolic processGO:00331212050.022
regulation of establishment of protein localizationGO:00702012420.022
protein ubiquitinationGO:00165673140.022
metal ion homeostasisGO:00550651690.022
hematopoietic or lymphoid organ developmentGO:00485341860.021
canonical wnt signaling pathwayGO:00600701160.021
cellular macromolecule catabolic processGO:00442653800.021
negative regulation of cellular amine metabolic processGO:003323930.021
response to hormoneGO:00097251750.021
Human
regulation of protein kinase activityGO:00458592890.021
anterior posterior axis specification embryoGO:000859520.021
regulation of nervous system developmentGO:0051960880.021
response to organic cyclic compoundGO:00140702040.021
adult locomotory behaviorGO:000834410.021
neural tube formationGO:000184130.021
regulation of cell morphogenesisGO:00226041530.021
startle responseGO:000196430.021
Fly
cell activationGO:00017752130.021
nerve developmentGO:002167540.021
regulation of cytokine productionGO:00018172320.021
regulation of growthGO:00400081650.021
regulation of cellular response to stressGO:00801352440.021
forebrain neuron developmentGO:002188420.020
protein targetingGO:00066051870.020
cellular protein complex assemblyGO:00436231880.020
cardiac right ventricle morphogenesisGO:000321530.020
protein maturationGO:00516042330.020
response to external biotic stimulusGO:00432072610.020
cell part morphogenesisGO:00329901370.020
gtp catabolic processGO:00061842370.020
positive regulation of apoptotic processGO:00430652460.020
regulation of ion transportGO:00432691890.020
cerebral cortex cell migrationGO:002179530.020
response to lipidGO:00339932060.020
endothelial cell migrationGO:0043542860.020
response to radiationGO:00093141510.020
cell projection assemblyGO:00300311260.020
heart morphogenesisGO:0003007480.020
Zebrafish Fly
response to transforming growth factor betaGO:0071559940.020
regulation of gtp catabolic processGO:00331241800.020
tripartite regional subdivisionGO:000735120.020
protein modification by small protein conjugationGO:00324463420.020
mesodermal cell fate specificationGO:000750120.020
apoptotic signaling pathwayGO:00971902680.019
regulation of canonical wnt signaling pathwayGO:0060828880.019
peripheral nervous system developmentGO:000742220.019
positive regulation of synaptic transmissionGO:005080640.019
negative regulation of cellular amino acid metabolic processGO:004576320.019
regulation of synaptic plasticityGO:004816730.019
neuroblast proliferationGO:000740540.019
rhythmic behaviorGO:000762220.019
regulation of nucleotide catabolic processGO:00308112050.019
cellular metal ion homeostasisGO:00068751460.019
positive regulation of nucleoside metabolic processGO:00459791860.019
regulation of cytoplasmic transportGO:19036491490.019
prostate gland developmentGO:003085030.019
regulation of secretion by cellGO:19035301770.019
negative regulation of protein modification processGO:00314002000.019
divalent metal ion transportGO:00708381520.019
protein processingGO:00164852260.019
spermatid differentiationGO:004851540.019
chromatin organizationGO:00063253510.019
posttranscriptional regulation of gene expressionGO:00106082130.019
microtubule based processGO:00070172100.019
divalent inorganic cation homeostasisGO:00725071360.019
regulation of chemotaxisGO:0050920740.019
tissue migrationGO:00901301190.019
establishment of planar polarityGO:000173630.019
carbohydrate metabolic processGO:00059752070.019
regulation of sequence specific dna binding transcription factor activityGO:00510902110.019
sequestering of metal ionGO:0051238240.019
detection of mechanical stimulusGO:005098240.019
regulation of cytoskeleton organizationGO:00514931770.019
muscle system processGO:0003012810.019
tissue regenerationGO:004224630.019
regulation of epithelial cell proliferationGO:00506781130.019
stem cell divisionGO:001714520.019
cell substrate adhesionGO:00315891320.019
nucleocytoplasmic transportGO:00069131760.019
positive regulation of programmed cell deathGO:00430682490.018
calcium ion transportGO:00068161470.018
neurotransmitter secretionGO:000726940.018
reactive nitrogen species metabolic processGO:200105730.018
innate immune responseGO:00450871780.018
lung alveolus developmentGO:004828640.018
divalent inorganic cation transportGO:00725111580.018
negative regulation of hydrolase activityGO:00513461820.018
positive regulation of nucleotide catabolic processGO:00308131850.018
epithelial cell migrationGO:00106311190.018
somatic stem cell maintenanceGO:003501940.018
response to bacteriumGO:00096171440.018
negative regulation of embryonic developmentGO:004599240.018
head developmentGO:00603221080.018
sequestering of calcium ionGO:0051208170.018
establishment of protein localization to organelleGO:00725941720.018
regulation of cell morphogenesis involved in differentiationGO:0010769830.018
cellular ion homeostasisGO:00068731680.018
regulation of neurogenesisGO:0050767820.018
cellular response to transforming growth factor beta stimulusGO:0071560940.018
calcium ion homeostasisGO:00550741220.017
negative regulation of cell cycleGO:00457861930.017
cation transmembrane transportGO:00986552380.017
g protein coupled receptor signaling pathwayGO:00071862070.017
positive regulation of kinase activityGO:00336742040.017
embryo developmentGO:00097901230.017
Fly
epithelial cell differentiationGO:00308551410.017
oocyte developmentGO:004859910.017
protein localization to nucleusGO:00345041360.017
positive regulation of transferase activityGO:00513472270.017
compound eye developmentGO:004874910.017
cellular response to cytokine stimulusGO:00713451810.017
regulation of peptidase activityGO:00525471800.017
circadian behaviorGO:004851220.017
nuclear transportGO:00511691790.017
positive regulation of organelle organizationGO:00106381950.017
positive regulation of cytokine productionGO:00018191670.017
inorganic cation transmembrane transportGO:00986621940.017
nitrogen compound transportGO:00717051910.017
regulation of ras protein signal transductionGO:00465781550.017
negative regulation of cell migrationGO:00303361020.017
somatic stem cell divisionGO:004810310.017
regulation of intracellular protein transportGO:00331571230.017
reactive oxygen species biosynthetic processGO:190340940.017
oocyte differentiationGO:000999420.017
chromatin modificationGO:00165682980.017
detection of mechanical stimulus involved in sensory perceptionGO:005097410.017
establishment of tissue polarityGO:000716430.017
primary neural tube formationGO:001402030.017
response to axon injuryGO:004867810.017
inorganic ion transmembrane transportGO:00986602310.017
limbic system developmentGO:002176130.017
glial cell migrationGO:000834740.017
response to inorganic substanceGO:00100351270.017
angiogenesisGO:00015251470.017
regulation of meiotic cell cycleGO:005144540.017
sensory perceptionGO:00076001030.017
negative regulation of epithelial cell proliferationGO:0050680480.017
brain developmentGO:0007420970.017
positive regulation of protein kinase activityGO:00458601900.017
microtubule cytoskeleton organizationGO:00002261760.017
cellular protein catabolic processGO:00442572610.017
regulation of gtpase activityGO:00430871800.017
response to nitrogen compoundGO:19016981840.016
monocarboxylic acid metabolic processGO:00327871850.016
somitogenesisGO:000175620.016
ribonucleoside monophosphate metabolic processGO:00091611870.016
small molecule biosynthetic processGO:00442831570.016
neuron projection regenerationGO:003110210.016
negative regulation of transportGO:00510511760.016
salivary gland morphogenesisGO:000743540.016
axis elongationGO:000340140.016
syncytium formation by plasma membrane fusionGO:000076820.016
regulation of reactive oxygen species biosynthetic processGO:190342630.016
purine ribonucleoside monophosphate metabolic processGO:00091671860.016
sensory perception of light stimulusGO:0050953350.016
wound healingGO:00420601150.016
oxidation reduction processGO:00551143960.016
blood circulationGO:00080151130.016
single organism carbohydrate metabolic processGO:00447231930.016
negative regulation of axonogenesisGO:005077140.016
regulation of body fluid levelsGO:0050878990.016
negative regulation of cell growthGO:0030308830.016
regulation of protein serine threonine kinase activityGO:00719001790.016
cell cycle phase transitionGO:00447701730.016
regulation of membrane potentialGO:0042391950.016
establishment or maintenance of apical basal cell polarityGO:003508820.016
cell cell signalingGO:00072671550.016
positive regulation of gtp catabolic processGO:00331261660.016
tube morphogenesisGO:0035239950.016
Mouse
positive regulation of cellular component biogenesisGO:00440891580.016
positive regulation of purine nucleotide catabolic processGO:00331231850.016
plasma membrane organizationGO:00070091150.016
protein oligomerizationGO:00512591730.016
positive regulation of gtpase activityGO:00435471660.016
positive regulation of protein transportGO:00512221350.016
purine nucleoside monophosphate metabolic processGO:00091261860.016
metencephalon developmentGO:002203720.016
regulation of defense responseGO:00313471540.016
cellular calcium ion homeostasisGO:00068741170.016
forebrain regionalizationGO:002187130.015
dermatome developmentGO:006105430.015
regulation of behaviorGO:0050795820.015
spermatid developmentGO:000728640.015
actin filament based movementGO:0030048170.015
regulation of homeostatic processGO:00328441210.015
negative regulation of cellular component movementGO:00512711060.015
regulation of angiogenesisGO:0045765920.015
positive regulation of cell projection organizationGO:0031346640.015
protein localization to membraneGO:00726571600.015
soft palate developmentGO:006002330.015
striated muscle contractionGO:0006941520.015
cellular response to lipidGO:00713961270.015
negative regulation of immune system processGO:00026831360.015
mitotic cell cycle phase transitionGO:00447721620.015
atp metabolic processGO:00460341760.015
nucleoside monophosphate catabolic processGO:00091251590.015
myoblast fusionGO:000752010.015
response to organonitrogen compoundGO:00102431560.015
regulation of neuron projection developmentGO:0010975570.015
regulation of vesicle mediated transportGO:00606271300.015
rna interferenceGO:001624640.015
visual behaviorGO:000763220.015
nucleoside monophosphate metabolic processGO:00091231910.015
negative regulation of phosphorylationGO:00423261740.015
neural crest cell developmentGO:001403230.015
muscle contractionGO:0006936730.015
mesodermal cell fate commitmentGO:000171020.015
cerebellum developmentGO:002154920.015
negative regulation of protein phosphorylationGO:00019331400.015
muscle cell fate commitmentGO:004269340.015
regulation of neural precursor cell proliferationGO:200017740.014
purine ribonucleoside monophosphate catabolic processGO:00091691580.014
histone modificationGO:00165702510.014
negative regulation of intracellular signal transductionGO:19025321830.014
regulation of ras gtpase activityGO:00323181280.014
positive regulation of wnt signaling pathwayGO:0030177540.014
organelle assemblyGO:00709251760.014
covalent chromatin modificationGO:00165692540.014
organophosphate biosynthetic processGO:00904071630.014
negative regulation of axon guidanceGO:190266810.014
regulation of ion homeostasisGO:2000021730.014
positive regulation of reactive oxygen species biosynthetic processGO:190342820.014
regulation of actin filament based processGO:00329701410.014
non canonical wnt signaling pathway via mapk cascadeGO:003803040.014
circulatory system processGO:00030131130.014
rna processingGO:00063962550.014
long term memoryGO:000761620.014
neuron fate commitmentGO:004866320.014
proteolysis involved in cellular protein catabolic processGO:00516032440.014
sex determinationGO:000753030.014
regulation of neurotransmitter secretionGO:004692830.014
lipid biosynthetic processGO:00086101770.014
reproductive processGO:00224141060.014
Human Fly
organic acid biosynthetic processGO:0016053970.014
regulation of small gtpase mediated signal transductionGO:00510561560.014
wnt signaling pathway calcium modulating pathwayGO:000722320.014
actin mediated cell contractionGO:0070252120.014
regulation of protein catabolic processGO:00421761550.014
skin developmentGO:0043588760.014
myeloid cell differentiationGO:00300991170.014
regulation of endothelial cell migrationGO:0010594670.014
leukocyte activationGO:00453211640.014
cardiac cell fate determinationGO:006091330.014
morphogenesis of an epitheliumGO:0002009600.014
Zebrafish Mouse
cell chemotaxisGO:00603261120.014

ROBO1 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
musculoskeletal system diseaseDOID:172230.049
connective tissue diseaseDOID:651090.033
nervous system diseaseDOID:8634310.024
central nervous system diseaseDOID:3311860.024
disease of metabolismDOID:00146672950.022
sensory system diseaseDOID:00501552030.022
bone diseaseDOID:0080001880.020
disease of cellular proliferationDOID:145661740.018
cancerDOID:1621670.017
eye diseaseDOID:56141490.017
eye and adnexa diseaseDOID:14921500.017
organ system cancerDOID:00506861640.017
inherited metabolic disorderDOID:6552420.016
muscular diseaseDOID:00800001140.016
myopathyDOID:4231040.015
muscle tissue diseaseDOID:661130.015
immune system diseaseDOID:29141550.015
bone development diseaseDOID:0080006550.015
cardiovascular system diseaseDOID:12871060.015
neurodegenerative diseaseDOID:12891020.014