| regulation of cyclase activity | GO:0031279 | 19 | 1.000 | Human |
| adenylate cyclase inhibiting adrenergic receptor signaling pathway | GO:0071881 | 1 | 1.000 | |
| adenylate cyclase modulating g protein coupled receptor signaling pathway | GO:0007188 | 43 | 1.000 | Mouse |
| negative regulation of insulin secretion involved in cellular response to glucose stimulus | GO:0061179 | 1 | 1.000 | |
| regulation of erk1 and erk2 cascade | GO:0070372 | 99 | 0.999 | |
| phospholipase c activating adrenergic receptor signaling pathway | GO:0071882 | 1 | 0.998 | |
| purine ribonucleotide biosynthetic process | GO:0009152 | 79 | 0.998 | Human |
| adenylate cyclase inhibiting serotonin receptor signaling pathway | GO:0007198 | 2 | 0.997 | |
| rab protein signal transduction | GO:0032482 | 4 | 0.997 | |
| organophosphate biosynthetic process | GO:0090407 | 163 | 0.992 | Human |
| regulation of ion transport | GO:0043269 | 189 | 0.990 | Human Mouse |
| positive regulation of rab gtpase activity | GO:0032851 | 39 | 0.988 | |
| g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger | GO:0007187 | 43 | 0.986 | Mouse |
| cyclic nucleotide biosynthetic process | GO:0009190 | 61 | 0.980 | Human |
| serotonin receptor signaling pathway | GO:0007210 | 11 | 0.971 | |
| regulation of membrane potential | GO:0042391 | 95 | 0.969 | |
| amine metabolic process | GO:0009308 | 44 | 0.963 | |
| negative regulation of nucleotide biosynthetic process | GO:0030809 | 11 | 0.960 | Human |
| cellular ketone metabolic process | GO:0042180 | 80 | 0.957 | |
| negative regulation of tyrosine phosphorylation of stat3 protein | GO:0042518 | 2 | 0.957 | |
| regulation of cyclic nucleotide metabolic process | GO:0030799 | 63 | 0.951 | Human |
| inorganic anion transmembrane transport | GO:0098661 | 47 | 0.950 | |
| positive regulation of phosphatidylinositol biosynthetic process | GO:0010513 | 3 | 0.949 | |
| organic hydroxy compound transport | GO:0015850 | 63 | 0.948 | Human Mouse |
| hippo signaling | GO:0035329 | 20 | 0.945 | |
| regulation of rab gtpase activity | GO:0032313 | 39 | 0.934 | |
| vesicle mediated transport | GO:0016192 | 371 | 0.933 | |
| regulation of purine nucleotide biosynthetic process | GO:1900371 | 50 | 0.932 | Human |
| nucleoside catabolic process | GO:0009164 | 408 | 0.928 | |
| carbohydrate derivative biosynthetic process | GO:1901137 | 207 | 0.927 | Human |
| regulation of blood vessel size | GO:0050880 | 18 | 0.918 | |
| regulation of nucleotide biosynthetic process | GO:0030808 | 50 | 0.910 | Human |
| glycerolipid metabolic process | GO:0046486 | 107 | 0.909 | |
| regulation of mapk cascade | GO:0043408 | 262 | 0.908 | |
| regulation of rab protein signal transduction | GO:0032483 | 39 | 0.905 | |
| ion homeostasis | GO:0050801 | 230 | 0.895 | Zebrafish Mouse |
| positive regulation of transmembrane transport | GO:0034764 | 41 | 0.893 | Human |
| positive regulation of vasodilation | GO:0045909 | 4 | 0.893 | |
| negative regulation of phosphorylation | GO:0042326 | 174 | 0.885 | |
| cellular amine metabolic process | GO:0044106 | 41 | 0.881 | |
| positive regulation of transport | GO:0051050 | 336 | 0.879 | Human |
| activation of mapk activity by adrenergic receptor signaling pathway | GO:0071883 | 3 | 0.878 | |
| cyclic purine nucleotide metabolic process | GO:0052652 | 60 | 0.867 | Human |
| cation transport | GO:0006812 | 331 | 0.866 | Human Mouse |
| inositol lipid mediated signaling | GO:0048017 | 55 | 0.864 | Mouse |
| dopamine receptor signaling pathway | GO:0007212 | 10 | 0.864 | Mouse |
| positive regulation of ras gtpase activity | GO:0032320 | 117 | 0.861 | |
| negative regulation of jak stat cascade | GO:0046426 | 4 | 0.856 | |
| positive regulation of mapk cascade | GO:0043410 | 190 | 0.854 | |
| cellular amino acid metabolic process | GO:0006520 | 116 | 0.854 | |
| negative regulation of cellular amine metabolic process | GO:0033239 | 3 | 0.847 | |
| membrane organization | GO:0061024 | 292 | 0.845 | Zebrafish |
| ras protein signal transduction | GO:0007265 | 73 | 0.842 | |
| second messenger mediated signaling | GO:0019932 | 78 | 0.841 | Mouse |
| regulation of ras gtpase activity | GO:0032318 | 128 | 0.839 | |
| glycosyl compound catabolic process | GO:1901658 | 413 | 0.839 | |
| organophosphate catabolic process | GO:0046434 | 430 | 0.836 | |
| negative regulation of transport | GO:0051051 | 176 | 0.836 | Mouse |
| gtp catabolic process | GO:0006184 | 237 | 0.833 | |
| regulation of cellular amino acid metabolic process | GO:0006521 | 6 | 0.824 | |
| cyclic nucleotide metabolic process | GO:0009187 | 82 | 0.819 | Human |
| regulation of peptidase activity | GO:0052547 | 180 | 0.803 | |
| nucleotide biosynthetic process | GO:0009165 | 109 | 0.798 | Human |
| desensitization of g protein coupled receptor protein signaling pathway by arrestin | GO:0002032 | 2 | 0.787 | |
| regulation of secretion | GO:0051046 | 194 | 0.780 | Mouse |
| negative regulation of phosphatidylinositol 3 kinase signaling | GO:0014067 | 4 | 0.777 | Mouse |
| purinergic nucleotide receptor signaling pathway | GO:0035590 | 4 | 0.772 | |
| positive regulation of hydrolase activity | GO:0051345 | 331 | 0.767 | |
| single organism cellular localization | GO:1902580 | 332 | 0.761 | Zebrafish |
| ribonucleotide biosynthetic process | GO:0009260 | 81 | 0.750 | Human |
| metaphase anaphase transition of cell cycle | GO:0044784 | 21 | 0.744 | |
| positive regulation of ion transport | GO:0043270 | 87 | 0.725 | Human |
| camp biosynthetic process | GO:0006171 | 47 | 0.725 | |
| negative regulation of cyclic nucleotide biosynthetic process | GO:0030803 | 10 | 0.724 | Human |
| hormone transport | GO:0009914 | 68 | 0.723 | |
| regulation of system process | GO:0044057 | 101 | 0.714 | Mouse |
| negative regulation of phosphate metabolic process | GO:0045936 | 267 | 0.711 | |
| bicarbonate transport | GO:0015701 | 6 | 0.709 | |
| regulation of purine nucleotide metabolic process | GO:1900542 | 264 | 0.709 | Human |
| regulation of gtp catabolic process | GO:0033124 | 180 | 0.708 | |
| negative regulation of protein kinase b signaling | GO:0051898 | 17 | 0.704 | |
| guanosine containing compound catabolic process | GO:1901069 | 239 | 0.701 | |
| cellular cation homeostasis | GO:0030003 | 163 | 0.700 | |
| negative regulation of tyrosine phosphorylation of stat protein | GO:0042532 | 2 | 0.700 | |
| regulation of camp biosynthetic process | GO:0030817 | 45 | 0.697 | |
| negative regulation of intracellular signal transduction | GO:1902532 | 183 | 0.693 | |
| cellular metal ion homeostasis | GO:0006875 | 146 | 0.688 | |
| negative regulation of cgmp metabolic process | GO:0030824 | 1 | 0.687 | Human |
| hormone secretion | GO:0046879 | 65 | 0.687 | |
| cell activation | GO:0001775 | 213 | 0.685 | |
| regulation of ion transmembrane transport | GO:0034765 | 132 | 0.675 | Human Mouse |
| negative regulation of cell adhesion | GO:0007162 | 64 | 0.673 | |
| retrograde transport endosome to golgi | GO:0042147 | 45 | 0.671 | |
| purine containing compound biosynthetic process | GO:0072522 | 88 | 0.670 | Human |
| erk1 and erk2 cascade | GO:0070371 | 104 | 0.664 | |
| purine nucleoside triphosphate catabolic process | GO:0009146 | 392 | 0.663 | |
| tyrosine phosphorylation of stat3 protein | GO:0042503 | 20 | 0.661 | |
| inorganic ion transmembrane transport | GO:0098660 | 231 | 0.652 | |
| positive regulation of gtpase activity | GO:0043547 | 166 | 0.652 | |
| positive regulation of nucleotide catabolic process | GO:0030813 | 185 | 0.644 | |
| glycerophospholipid metabolic process | GO:0006650 | 84 | 0.643 | |
| positive regulation of cell proliferation | GO:0008284 | 301 | 0.640 | |
| anterior posterior axis specification | GO:0009948 | 2 | 0.638 | |
| purine ribonucleotide catabolic process | GO:0009154 | 404 | 0.626 | |
| potassium ion transport | GO:0006813 | 62 | 0.625 | |
| sensory perception of pain | GO:0019233 | 4 | 0.624 | |
| regulation of nucleotide metabolic process | GO:0006140 | 269 | 0.620 | Human |
| regulation of ras protein signal transduction | GO:0046578 | 155 | 0.620 | |
| negative regulation of secretion by cell | GO:1903531 | 52 | 0.615 | |
| regulation of transmembrane transport | GO:0034762 | 139 | 0.615 | Human Mouse |
| regulation of tube size | GO:0035150 | 18 | 0.605 | |
| regulation of cysteine type endopeptidase activity | GO:2000116 | 127 | 0.605 | |
| post embryonic development | GO:0009791 | 2 | 0.601 | |
| negative regulation of nucleotide metabolic process | GO:0045980 | 29 | 0.598 | Human |
| purine ribonucleoside triphosphate metabolic process | GO:0009205 | 411 | 0.593 | |
| metal ion transport | GO:0030001 | 272 | 0.575 | Mouse |
| positive regulation of ion transmembrane transport | GO:0034767 | 40 | 0.574 | Human |
| heart contraction | GO:0060047 | 62 | 0.570 | |
| regulation of small gtpase mediated signal transduction | GO:0051056 | 156 | 0.566 | |
| vasodilation | GO:0042311 | 4 | 0.560 | |
| positive regulation of programmed cell death | GO:0043068 | 249 | 0.559 | |
| adenylate cyclase activating dopamine receptor signaling pathway | GO:0007191 | 3 | 0.558 | Mouse |
| regulation of lymphocyte migration | GO:2000401 | 22 | 0.554 | |
| regulation of intrinsic apoptotic signaling pathway | GO:2001242 | 72 | 0.552 | |
| peptidyl tyrosine modification | GO:0018212 | 170 | 0.552 | |
| guanosine containing compound metabolic process | GO:1901068 | 244 | 0.550 | |
| nucleoside phosphate biosynthetic process | GO:1901293 | 109 | 0.550 | Human |
| cgmp metabolic process | GO:0046068 | 19 | 0.547 | Human |
| regulation of mitotic sister chromatid separation | GO:0010965 | 27 | 0.540 | |
| cation transmembrane transport | GO:0098655 | 238 | 0.539 | Mouse |
| lipid metabolic process | GO:0006629 | 381 | 0.538 | |
| positive regulation of nucleoside metabolic process | GO:0045979 | 186 | 0.532 | |
| negative regulation of tyrosine phosphorylation of stat5 protein | GO:0042524 | 1 | 0.531 | |
| regulation of proteolysis | GO:0030162 | 293 | 0.531 | |
| positive regulation of purine nucleotide catabolic process | GO:0033123 | 185 | 0.529 | |
| cellular divalent inorganic cation homeostasis | GO:0072503 | 128 | 0.521 | |
| protein maturation | GO:0051604 | 233 | 0.520 | |
| nucleoside phosphate catabolic process | GO:1901292 | 412 | 0.520 | |
| regulation of nucleotide catabolic process | GO:0030811 | 205 | 0.519 | |
| regulation of nucleoside metabolic process | GO:0009118 | 209 | 0.519 | |
| negative regulation of neurological system process | GO:0031645 | 2 | 0.518 | |
| regulation of lyase activity | GO:0051339 | 23 | 0.516 | Human |
| regulation of vasodilation | GO:0042312 | 4 | 0.503 | |
| diet induced thermogenesis | GO:0002024 | 2 | 0.501 | |
| regulation of apoptotic signaling pathway | GO:2001233 | 175 | 0.500 | |
| negative regulation of peptidyl tyrosine phosphorylation | GO:0050732 | 20 | 0.499 | |
| regulation of cellular amine metabolic process | GO:0033238 | 11 | 0.494 | |
| positive regulation of nucleotide metabolic process | GO:0045981 | 230 | 0.492 | |
| regulation of nuclear division | GO:0051783 | 65 | 0.491 | |
| monovalent inorganic cation transport | GO:0015672 | 128 | 0.490 | Mouse |
| positive regulation of camp biosynthetic process | GO:0030819 | 35 | 0.486 | |
| negative regulation of platelet aggregation | GO:0090331 | 3 | 0.486 | |
| purine nucleotide catabolic process | GO:0006195 | 405 | 0.484 | |
| cytosolic calcium ion homeostasis | GO:0051480 | 89 | 0.473 | |
| anterior posterior axis specification embryo | GO:0008595 | 2 | 0.472 | |
| ribonucleoside triphosphate metabolic process | GO:0009199 | 412 | 0.471 | |
| negative regulation of cellular amino acid metabolic process | GO:0045763 | 2 | 0.471 | |
| negative regulation of blood pressure | GO:0045776 | 3 | 0.467 | |
| purine ribonucleoside triphosphate catabolic process | GO:0009207 | 391 | 0.467 | |
| purine containing compound catabolic process | GO:0072523 | 411 | 0.462 | |
| protein localization to plasma membrane | GO:0072659 | 93 | 0.450 | |
| adenylate cyclase activating adrenergic receptor signaling pathway | GO:0071880 | 3 | 0.449 | |
| positive regulation of apoptotic process | GO:0043065 | 246 | 0.447 | |
| epidermal growth factor activated receptor transactivation by g protein coupled receptor signaling pathway | GO:0035625 | 4 | 0.441 | |
| positive regulation of protein phosphorylation | GO:0001934 | 313 | 0.427 | |
| signal release | GO:0023061 | 70 | 0.425 | |
| cellular chemical homeostasis | GO:0055082 | 180 | 0.419 | Mouse |
| regulation of mitotic sister chromatid segregation | GO:0033047 | 27 | 0.419 | |
| single organism membrane organization | GO:0044802 | 268 | 0.413 | Zebrafish |
| positive regulation of erk1 and erk2 cascade | GO:0070374 | 75 | 0.411 | |
| divalent metal ion transport | GO:0070838 | 152 | 0.410 | |
| adenylate cyclase activating g protein coupled receptor signaling pathway | GO:0007189 | 18 | 0.409 | Mouse |
| blastoderm segmentation | GO:0007350 | 2 | 0.408 | |
| positive regulation of apoptotic signaling pathway | GO:2001235 | 70 | 0.405 | |
| purine nucleoside triphosphate metabolic process | GO:0009144 | 412 | 0.401 | |
| positive regulation of cellular amine metabolic process | GO:0033240 | 7 | 0.401 | |
| cell projection organization | GO:0030030 | 252 | 0.398 | |
| activation of phospholipase c activity | GO:0007202 | 7 | 0.397 | |
| activation of cysteine type endopeptidase activity | GO:0097202 | 57 | 0.391 | |
| regulation of guanylate cyclase activity | GO:0031282 | 2 | 0.389 | Human |
| purine nucleotide biosynthetic process | GO:0006164 | 84 | 0.384 | Human |
| zymogen activation | GO:0031638 | 70 | 0.382 | |
| lymphocyte migration | GO:0072676 | 28 | 0.377 | |
| signal transduction by phosphorylation | GO:0023014 | 297 | 0.375 | |
| regulation of cellular ketone metabolic process | GO:0010565 | 50 | 0.373 | |
| regulation of cell division | GO:0051302 | 116 | 0.370 | |
| negative regulation of protein metabolic process | GO:0051248 | 391 | 0.368 | |
| regulation of leukocyte activation | GO:0002694 | 115 | 0.364 | |
| apoptotic signaling pathway | GO:0097190 | 268 | 0.364 | |
| organelle assembly | GO:0070925 | 176 | 0.364 | |
| mapk cascade | GO:0000165 | 288 | 0.363 | |
| regulation of gtpase activity | GO:0043087 | 180 | 0.361 | |
| receptor internalization | GO:0031623 | 43 | 0.361 | |
| nucleoside triphosphate catabolic process | GO:0009143 | 394 | 0.356 | |
| chloride transport | GO:0006821 | 41 | 0.355 | |
| regulation of calcium ion transport | GO:0051924 | 79 | 0.355 | |
| positive regulation of calcium ion transport | GO:0051928 | 51 | 0.354 | |
| modification dependent protein catabolic process | GO:0019941 | 209 | 0.350 | |
| regulation of cell cell adhesion | GO:0022407 | 57 | 0.349 | |
| regulation of mitotic cell cycle | GO:0007346 | 189 | 0.344 | |
| positive regulation of adenylate cyclase activity | GO:0045762 | 12 | 0.344 | |
| regulation of camp metabolic process | GO:0030814 | 52 | 0.344 | |
| positive regulation of camp metabolic process | GO:0030816 | 41 | 0.342 | |
| determination of adult lifespan | GO:0008340 | 2 | 0.342 | Worm |
| protein localization to membrane | GO:0072657 | 160 | 0.341 | Zebrafish |
| negative regulation of protein modification process | GO:0031400 | 200 | 0.339 | |
| regulation of tyrosine phosphorylation of stat5 protein | GO:0042522 | 12 | 0.339 | |
| membrane to membrane docking | GO:0022614 | 5 | 0.338 | |
| renal system process | GO:0003014 | 25 | 0.337 | |
| plasma membrane organization | GO:0007009 | 115 | 0.334 | |
| positive regulation of inositol trisphosphate biosynthetic process | GO:0032962 | 1 | 0.332 | |
| alcohol metabolic process | GO:0006066 | 114 | 0.330 | |
| single organismal cell cell adhesion | GO:0016337 | 148 | 0.328 | |
| negative regulation of cellular protein metabolic process | GO:0032269 | 353 | 0.327 | |
| amino acid betaine transport | GO:0015838 | 4 | 0.324 | Human |
| nitrogen compound transport | GO:0071705 | 191 | 0.323 | Human Mouse |
| regulation of cell adhesion | GO:0030155 | 166 | 0.322 | |
| regulation of mitosis | GO:0007088 | 63 | 0.319 | |
| positive regulation of purine nucleotide metabolic process | GO:1900544 | 227 | 0.313 | |
| positive regulation of gtp catabolic process | GO:0033126 | 166 | 0.312 | |
| phospholipase c activating dopamine receptor signaling pathway | GO:0060158 | 2 | 0.312 | Mouse |
| positive regulation of cellular catabolic process | GO:0031331 | 284 | 0.307 | |
| regulation of metal ion transport | GO:0010959 | 120 | 0.303 | Mouse |
| glomerular mesangial cell proliferation | GO:0072110 | 3 | 0.302 | |
| ribonucleoside catabolic process | GO:0042454 | 406 | 0.302 | |
| inorganic cation transmembrane transport | GO:0098662 | 194 | 0.301 | Mouse |
| regulation of peptidyl tyrosine phosphorylation | GO:0050730 | 108 | 0.297 | |
| negative regulation of dna replication | GO:0008156 | 29 | 0.296 | |
| cardiac muscle cell contraction | GO:0086003 | 4 | 0.296 | |
| ameboidal type cell migration | GO:0001667 | 135 | 0.295 | |
| regulation of purine nucleotide catabolic process | GO:0033121 | 205 | 0.294 | |
| single organism cell adhesion | GO:0098602 | 179 | 0.294 | |
| g protein coupled receptor signaling pathway | GO:0007186 | 207 | 0.293 | Mouse |
| cell migration involved in gastrulation | GO:0042074 | 1 | 0.293 | |
| vascular process in circulatory system | GO:0003018 | 29 | 0.292 | |
| respiratory system development | GO:0060541 | 22 | 0.292 | |
| regulation of chemotaxis | GO:0050920 | 74 | 0.292 | |
| negative regulation of cell proliferation | GO:0008285 | 228 | 0.292 | |
| positive regulation of inositol phosphate biosynthetic process | GO:0060732 | 2 | 0.289 | |
| skeletal muscle tissue growth | GO:0048630 | 2 | 0.288 | |
| regulation of muscle system process | GO:0090257 | 53 | 0.287 | |
| copulation | GO:0007620 | 1 | 0.285 | |
| intrinsic apoptotic signaling pathway | GO:0097193 | 127 | 0.284 | |
| regulation of anion channel activity | GO:0010359 | 2 | 0.282 | |
| regulation of sensory perception of pain | GO:0051930 | 3 | 0.281 | |
| female gamete generation | GO:0007292 | 2 | 0.276 | |
| positive regulation of peptidase activity | GO:0010952 | 88 | 0.275 | |
| positive regulation of nucleotide biosynthetic process | GO:0030810 | 38 | 0.275 | |
| chloride transmembrane transport | GO:1902476 | 38 | 0.273 | |
| chromosome separation | GO:0051304 | 23 | 0.272 | |
| positive regulation of multicellular organismal metabolic process | GO:0044253 | 11 | 0.271 | |
| cellular response to endogenous stimulus | GO:0071495 | 336 | 0.269 | |
| positive regulation of camp mediated signaling | GO:0043950 | 10 | 0.267 | |
| negative regulation of secretion | GO:0051048 | 58 | 0.263 | |
| endosomal transport | GO:0016197 | 129 | 0.262 | |
| nuclear division | GO:0000280 | 128 | 0.262 | |
| regulation of insulin secretion | GO:0050796 | 33 | 0.260 | |
| ribonucleoside triphosphate catabolic process | GO:0009203 | 391 | 0.259 | |
| tyrosine phosphorylation of stat5 protein | GO:0042506 | 13 | 0.258 | |
| positive regulation of calcium ion transport into cytosol | GO:0010524 | 20 | 0.257 | |
| regulation of lipid catabolic process | GO:0050994 | 23 | 0.257 | |
| positive regulation of cytosolic calcium ion concentration involved in phospholipase c activating g protein coupled signaling pathway | GO:0051482 | 6 | 0.256 | |
| regulation of muscle contraction | GO:0006937 | 45 | 0.256 | |
| negative regulation of cyclic nucleotide metabolic process | GO:0030800 | 10 | 0.256 | Human |
| skeletal muscle contraction | GO:0003009 | 16 | 0.255 | |
| ion transmembrane transport | GO:0034220 | 338 | 0.253 | |
| sensory perception | GO:0007600 | 103 | 0.250 | Mouse |
| receptor transactivation | GO:0035624 | 4 | 0.250 | |
| jak stat cascade | GO:0007259 | 46 | 0.248 | |
| receptor mediated endocytosis | GO:0006898 | 84 | 0.248 | |
| cation homeostasis | GO:0055080 | 189 | 0.247 | Zebrafish |
| ribonucleoside monophosphate catabolic process | GO:0009158 | 158 | 0.244 | |
| musculoskeletal movement | GO:0050881 | 17 | 0.244 | |
| protein catabolic process | GO:0030163 | 325 | 0.244 | |
| endomembrane system organization | GO:0010256 | 196 | 0.244 | |
| lipid biosynthetic process | GO:0008610 | 177 | 0.241 | |
| phosphatidylinositol mediated signaling | GO:0048015 | 55 | 0.240 | Mouse |
| positive regulation of cyclic nucleotide metabolic process | GO:0030801 | 49 | 0.240 | |
| negative regulation of catalytic activity | GO:0043086 | 335 | 0.239 | Human |
| positive regulation of proteolysis | GO:0045862 | 142 | 0.239 | |
| intestine smooth muscle contraction | GO:0014827 | 2 | 0.238 | |
| positive regulation of ossification | GO:0045778 | 32 | 0.237 | |
| adenylate cyclase inhibiting g protein coupled receptor signaling pathway | GO:0007193 | 22 | 0.237 | |
| regeneration | GO:0031099 | 4 | 0.236 | |
| purine nucleoside catabolic process | GO:0006152 | 398 | 0.234 | |
| negative regulation of phosphorus metabolic process | GO:0010563 | 267 | 0.234 | |
| regulation of postsynaptic membrane potential | GO:0060078 | 1 | 0.233 | |
| regulation of multicellular organismal metabolic process | GO:0044246 | 17 | 0.233 | |
| organic anion transport | GO:0015711 | 103 | 0.233 | Human Mouse |
| ribose phosphate biosynthetic process | GO:0046390 | 82 | 0.231 | Human |
| positive regulation of cellular amino acid metabolic process | GO:0045764 | 3 | 0.231 | |
| cell development | GO:0048468 | 328 | 0.227 | Mouse |
| positive regulation of purine nucleotide biosynthetic process | GO:1900373 | 38 | 0.227 | |
| regulation of blood circulation | GO:1903522 | 59 | 0.225 | |
| regulation of map kinase activity | GO:0043405 | 108 | 0.223 | |
| regulation of locomotion | GO:0040012 | 329 | 0.223 | Mouse |
| myosin filament assembly | GO:0031034 | 2 | 0.223 | |
| nucleotide catabolic process | GO:0009166 | 408 | 0.221 | |
| trachea development | GO:0060438 | 1 | 0.220 | |
| regulation of cellular component movement | GO:0051270 | 334 | 0.217 | Mouse |
| organelle fission | GO:0048285 | 149 | 0.216 | |
| transmembrane transport | GO:0055085 | 399 | 0.212 | |
| oligodendrocyte development | GO:0014003 | 6 | 0.205 | |
| positive regulation of lipid biosynthetic process | GO:0046889 | 22 | 0.204 | |
| cellular lipid metabolic process | GO:0044255 | 303 | 0.202 | |
| organonitrogen compound biosynthetic process | GO:1901566 | 200 | 0.202 | Human |
| regulation of endopeptidase activity | GO:0052548 | 170 | 0.202 | |
| presynaptic membrane organization | GO:0097090 | 3 | 0.200 | |
| regulation of cell activation | GO:0050865 | 125 | 0.198 | |
| peptide hormone secretion | GO:0030072 | 50 | 0.198 | |
| regulation of leukocyte migration | GO:0002685 | 63 | 0.194 | |
| negative regulation of phagocytosis | GO:0050765 | 4 | 0.194 | |
| regulation of vesicle mediated transport | GO:0060627 | 130 | 0.192 | |
| cytoplasmic transport | GO:0016482 | 379 | 0.192 | |
| divalent inorganic cation homeostasis | GO:0072507 | 136 | 0.191 | |
| wound healing | GO:0042060 | 115 | 0.190 | |
| organic hydroxy compound biosynthetic process | GO:1901617 | 71 | 0.190 | |
| regulation of hormone secretion | GO:0046883 | 57 | 0.190 | |
| peptidyl tyrosine phosphorylation | GO:0018108 | 170 | 0.189 | |
| regulation of tyrosine phosphorylation of stat3 protein | GO:0042516 | 18 | 0.188 | |
| sequestering of calcium ion | GO:0051208 | 17 | 0.188 | |
| endocytosis | GO:0006897 | 159 | 0.187 | |
| regulation of secretion by cell | GO:1903530 | 177 | 0.187 | |
| proteasome mediated ubiquitin dependent protein catabolic process | GO:0043161 | 156 | 0.187 | |
| phospholipid metabolic process | GO:0006644 | 99 | 0.187 | |
| regulation of the force of heart contraction by chemical signal | GO:0003057 | 1 | 0.187 | |
| lipid catabolic process | GO:0016042 | 84 | 0.186 | |
| secretion by cell | GO:0032940 | 226 | 0.186 | |
| negative regulation of purine nucleotide biosynthetic process | GO:1900372 | 11 | 0.186 | Human |
| striated muscle contraction | GO:0006941 | 52 | 0.184 | |
| regulation of protein stability | GO:0031647 | 87 | 0.184 | |
| positive regulation of cytosolic calcium ion concentration | GO:0007204 | 82 | 0.183 | |
| protein kinase c signaling | GO:0070528 | 17 | 0.180 | |
| cellular response to hypoxia | GO:0071456 | 51 | 0.180 | |
| response to dietary excess | GO:0002021 | 2 | 0.178 | |
| regulation of phosphatidylinositol biosynthetic process | GO:0010511 | 5 | 0.178 | |
| regulation of t cell activation | GO:0050863 | 77 | 0.177 | |
| negative regulation of protein phosphorylation | GO:0001933 | 140 | 0.174 | |
| regulation of atpase activity | GO:0043462 | 25 | 0.173 | |
| glycerolipid biosynthetic process | GO:0045017 | 51 | 0.173 | |
| regulation of ion homeostasis | GO:2000021 | 73 | 0.172 | |
| establishment of endothelial barrier | GO:0061028 | 16 | 0.171 | |
| positive regulation of cytoplasmic transport | GO:1903651 | 82 | 0.170 | |
| negative regulation of blood coagulation | GO:0030195 | 22 | 0.169 | |
| gtp metabolic process | GO:0046039 | 239 | 0.169 | |
| muscle cell development | GO:0055001 | 29 | 0.169 | |
| negative regulation of muscle contraction | GO:0045932 | 3 | 0.166 | |
| cellular response to organonitrogen compound | GO:0071417 | 124 | 0.166 | |
| regulation of atp metabolic process | GO:1903578 | 29 | 0.165 | |
| positive regulation of cytokine production | GO:0001819 | 167 | 0.164 | |
| regulation of camp mediated signaling | GO:0043949 | 13 | 0.164 | |
| startle response | GO:0001964 | 3 | 0.163 | |
| regulation of systemic arterial blood pressure mediated by a chemical signal | GO:0003044 | 12 | 0.161 | |
| positive regulation of intrinsic apoptotic signaling pathway | GO:2001244 | 28 | 0.161 | |
| peptide transport | GO:0015833 | 74 | 0.160 | Mouse |
| ribonucleoside monophosphate metabolic process | GO:0009161 | 187 | 0.159 | |
| lymphocyte activation | GO:0046649 | 133 | 0.159 | |
| platelet aggregation | GO:0070527 | 32 | 0.159 | |
| transepithelial transport | GO:0070633 | 9 | 0.159 | |
| oocyte development | GO:0048599 | 1 | 0.159 | |
| muscle contraction | GO:0006936 | 73 | 0.155 | |
| secretion | GO:0046903 | 254 | 0.154 | Mouse |
| calcium mediated signaling | GO:0019722 | 44 | 0.154 | |
| locomotory behavior | GO:0007626 | 1 | 0.152 | |
| mitotic sister chromatid separation | GO:0051306 | 18 | 0.152 | |
| positive regulation of synaptic transmission | GO:0050806 | 4 | 0.151 | |
| regulation of jak stat cascade | GO:0046425 | 44 | 0.151 | |
| positive regulation of lipase activity | GO:0060193 | 28 | 0.150 | |
| sodium ion transmembrane transport | GO:0035725 | 59 | 0.149 | Mouse |
| regulation of dephosphorylation | GO:0035303 | 96 | 0.148 | |
| multicellular organismal aging | GO:0010259 | 3 | 0.145 | Worm |
| regulation of hemostasis | GO:1900046 | 42 | 0.144 | |
| regulation of peptide hormone secretion | GO:0090276 | 41 | 0.144 | |
| regulation of protein localization | GO:0032880 | 296 | 0.143 | |
| blood circulation | GO:0008015 | 113 | 0.143 | |
| phospholipid biosynthetic process | GO:0008654 | 44 | 0.142 | |
| leukocyte activation | GO:0045321 | 164 | 0.142 | |
| regulation of hormone levels | GO:0010817 | 125 | 0.142 | |
| kidney morphogenesis | GO:0060993 | 19 | 0.140 | |
| negative regulation of cyclase activity | GO:0031280 | 6 | 0.139 | Human |
| cellular response to nitrogen compound | GO:1901699 | 144 | 0.138 | |
| proteasomal protein catabolic process | GO:0010498 | 176 | 0.138 | |
| regulation of kinase activity | GO:0043549 | 314 | 0.137 | Mouse |
| regulation of coagulation | GO:0050818 | 44 | 0.137 | |
| endothelial cell development | GO:0001885 | 18 | 0.137 | |
| positive regulation of potassium ion transport | GO:0043268 | 15 | 0.136 | |
| negative regulation of erk1 and erk2 cascade | GO:0070373 | 14 | 0.135 | |
| establishment of protein localization to membrane | GO:0090150 | 121 | 0.134 | Zebrafish |
| sister chromatid segregation | GO:0000819 | 54 | 0.134 | |
| regulation of inositol phosphate biosynthetic process | GO:0010919 | 3 | 0.134 | |
| multicellular organismal movement | GO:0050879 | 17 | 0.133 | |
| digestive system development | GO:0055123 | 75 | 0.132 | |
| positive regulation of map kinase activity | GO:0043406 | 80 | 0.132 | |
| organic hydroxy compound metabolic process | GO:1901615 | 147 | 0.132 | |
| dna replication | GO:0006260 | 116 | 0.131 | |
| regulation of chromosome segregation | GO:0051983 | 44 | 0.129 | |
| metal ion homeostasis | GO:0055065 | 169 | 0.128 | Zebrafish |
| proteolysis involved in cellular protein catabolic process | GO:0051603 | 244 | 0.128 | |
| t cell activation | GO:0042110 | 99 | 0.127 | |
| digestive tract development | GO:0048565 | 75 | 0.127 | |
| regulation of protein serine threonine kinase activity | GO:0071900 | 179 | 0.126 | |
| regulation of chromosome organization | GO:0033044 | 103 | 0.126 | |
| regulation of cytoskeleton organization | GO:0051493 | 177 | 0.124 | |
| regulation of sequestering of calcium ion | GO:0051282 | 41 | 0.122 | |
| calcium ion homeostasis | GO:0055074 | 122 | 0.122 | |
| cellular ion homeostasis | GO:0006873 | 168 | 0.121 | Mouse |
| biological adhesion | GO:0022610 | 331 | 0.121 | |
| oocyte differentiation | GO:0009994 | 2 | 0.121 | |
| activation of protein kinase b activity | GO:0032148 | 14 | 0.119 | |
| negative regulation of purine nucleotide metabolic process | GO:1900543 | 28 | 0.117 | Human |
| g protein coupled purinergic nucleotide receptor signaling pathway | GO:0035589 | 1 | 0.116 | |
| positive regulation of cell differentiation | GO:0045597 | 211 | 0.116 | |
| tube development | GO:0035295 | 125 | 0.115 | |
| reproductive process | GO:0022414 | 106 | 0.115 | |
| regulation of chloride transport | GO:2001225 | 2 | 0.115 | |
| regulation of cytoplasmic transport | GO:1903649 | 149 | 0.114 | |
| regulation of intracellular protein transport | GO:0033157 | 123 | 0.113 | |
| epithelial cell differentiation | GO:0030855 | 141 | 0.113 | Mouse |
| nervous system development | GO:0007399 | 293 | 0.112 | Mouse |
| regulation of sister chromatid segregation | GO:0033045 | 27 | 0.110 | |
| response to nitrogen compound | GO:1901698 | 184 | 0.110 | |
| cellular component assembly involved in morphogenesis | GO:0010927 | 73 | 0.110 | |
| cellular response to decreased oxygen levels | GO:0036294 | 51 | 0.109 | |
| negative regulation of mapk cascade | GO:0043409 | 56 | 0.109 | |
| cell cell signaling | GO:0007267 | 155 | 0.109 | |
| chromosome segregation | GO:0007059 | 114 | 0.107 | |
| tripartite regional subdivision | GO:0007351 | 2 | 0.106 | |
| regulation of cyclic nucleotide biosynthetic process | GO:0030802 | 49 | 0.105 | Human |
| regulation of sodium ion transmembrane transport | GO:1902305 | 23 | 0.104 | Mouse |
| cell adhesion | GO:0007155 | 325 | 0.104 | |
| regulation of binding | GO:0051098 | 111 | 0.104 | |
| respiratory gaseous exchange | GO:0007585 | 3 | 0.103 | |
| atp catabolic process | GO:0006200 | 157 | 0.103 | |
| negative regulation of dendritic spine development | GO:0061000 | 1 | 0.102 | |
| negative regulation of response to wounding | GO:1903035 | 47 | 0.102 | |
| epithelium development | GO:0060429 | 227 | 0.102 | Mouse |
| positive regulation of endocytosis | GO:0045807 | 42 | 0.100 | |
| anatomical structure homeostasis | GO:0060249 | 100 | 0.100 | |
| anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process | GO:0031145 | 25 | 0.099 | |
| regulation of cell migration | GO:0030334 | 289 | 0.099 | Mouse |
| regulation of ion transmembrane transporter activity | GO:0032412 | 72 | 0.099 | Mouse |
| striated muscle myosin thick filament assembly | GO:0071688 | 2 | 0.099 | |
| immune response | GO:0006955 | 307 | 0.099 | |
| negative regulation of peptide hormone secretion | GO:0090278 | 10 | 0.098 | |
| rhythmic behavior | GO:0007622 | 2 | 0.097 | |
| activation of mapk activity | GO:0000187 | 45 | 0.097 | |
| regulation of stress activated protein kinase signaling cascade | GO:0070302 | 85 | 0.096 | |
| adrenergic receptor signaling pathway | GO:0071875 | 9 | 0.096 | |
| regulation of protein kinase b signaling | GO:0051896 | 61 | 0.095 | |
| actin cytoskeleton organization | GO:0030036 | 207 | 0.095 | Mouse |
| establishment or maintenance of epithelial cell apical basal polarity | GO:0045197 | 1 | 0.094 | |
| digestive tract morphogenesis | GO:0048546 | 56 | 0.093 | |
| muscle tissue development | GO:0060537 | 62 | 0.093 | |
| phosphatidylinositol 3 kinase signaling | GO:0014065 | 48 | 0.093 | Mouse |
| protein ubiquitination | GO:0016567 | 314 | 0.093 | |
| positive regulation of cellular component movement | GO:0051272 | 181 | 0.092 | |
| glial cell migration | GO:0008347 | 4 | 0.092 | |
| cellular calcium ion homeostasis | GO:0006874 | 117 | 0.092 | |
| presynaptic membrane assembly | GO:0097105 | 1 | 0.092 | |
| muscle structure development | GO:0061061 | 98 | 0.092 | |
| positive regulation of lymphocyte proliferation | GO:0050671 | 46 | 0.092 | |
| positive regulation of actin filament bundle assembly | GO:0032233 | 25 | 0.091 | |
| regulation of blood pressure | GO:0008217 | 30 | 0.090 | |
| positive regulation of membrane potential | GO:0045838 | 2 | 0.089 | |
| segmentation | GO:0035282 | 4 | 0.089 | |
| regulation of metanephric mesenchymal cell migration | GO:2000589 | 2 | 0.088 | |
| cell projection assembly | GO:0030031 | 126 | 0.088 | |
| regulation of heart contraction | GO:0008016 | 50 | 0.087 | |
| monocarboxylic acid transport | GO:0015718 | 32 | 0.087 | Human Mouse |
| establishment of organelle localization | GO:0051656 | 59 | 0.087 | |
| positive regulation of jnk cascade | GO:0046330 | 52 | 0.087 | |
| cytokine production | GO:0001816 | 247 | 0.086 | |
| regulation of stress fiber assembly | GO:0051492 | 32 | 0.085 | |
| regulation of response to external stimulus | GO:0032101 | 222 | 0.085 | |
| biomineral tissue development | GO:0031214 | 39 | 0.085 | |
| blood vessel morphogenesis | GO:0048514 | 162 | 0.084 | |
| memory | GO:0007613 | 3 | 0.084 | |
| myosin filament organization | GO:0031033 | 2 | 0.084 | |
| spermatid development | GO:0007286 | 4 | 0.084 | |
| regulation of transferase activity | GO:0051338 | 355 | 0.084 | Mouse |
| organ morphogenesis | GO:0009887 | 147 | 0.084 | Mouse |
