IMP: Integrative Multi-species Prediction

Homo sapiens

0 known processes

SOCS1

suppressor of cytokine signaling 1

(Aliases: SOCS-1,CISH1,CIS1,SSI-1,SSI1,TIP3,JAB)

HGNC: 19383
Entrez: 8651
MIM: 603597
Ensembl: ENSG00000185338
HPRD: 04669
UniProtKB: O15524
UniProtKB: Q4JHT5

Process Predictions
Disease Predictions

SOCS1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
regulation of sequence specific dna binding transcription factor activity	GO:0051090	211	0.996
regulation of cellular amine metabolic process	GO:0033238	11	0.992
cellular amine metabolic process	GO:0044106	41	0.991
amine metabolic process	GO:0009308	44	0.989
cellular response to endogenous stimulus	GO:0071495	336	0.988	Human Mouse
regulation of cellular amino acid metabolic process	GO:0006521	6	0.987
enzyme linked receptor protein signaling pathway	GO:0007167	303	0.981	Human Mouse
regulation of cellular ketone metabolic process	GO:0010565	50	0.979
positive regulation of proteolysis	GO:0045862	142	0.944	Human
positive regulation of cellular amine metabolic process	GO:0033240	7	0.908
cellular ketone metabolic process	GO:0042180	80	0.892
cellular response to oxygen containing compound	GO:1901701	276	0.880	Human Mouse
cellular response to hormone stimulus	GO:0032870	125	0.868	Human Mouse
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	181	0.856	Human Mouse
cellular response to cytokine stimulus	GO:0071345	181	0.854	Zebrafish Mouse
cellular macromolecule catabolic process	GO:0044265	380	0.853	Human
regulation of transferase activity	GO:0051338	355	0.852	Human Mouse
cytokine mediated signaling pathway	GO:0019221	109	0.845	Zebrafish Mouse
regulation of kinase activity	GO:0043549	314	0.842	Human Mouse
regulation of proteolysis	GO:0030162	293	0.821	Human
regulation of cellular response to stress	GO:0080135	244	0.782
response to hormone	GO:0009725	175	0.779	Human Mouse Rat
positive regulation of proteasomal protein catabolic process	GO:1901800	35	0.770	Human
negative regulation of sequence specific dna binding transcription factor activity	GO:0043433	89	0.762
cellular response to peptide hormone stimulus	GO:0071375	56	0.760	Human Mouse
defense response	GO:0006952	315	0.759	Zebrafish
segmentation	GO:0035282	4	0.751
peptidyl tyrosine modification	GO:0018212	170	0.743	Human Mouse
cellular response to growth hormone stimulus	GO:0071378	10	0.723	Human
cell development	GO:0048468	328	0.722
stem cell differentiation	GO:0048863	93	0.715
regulation of peptidyl tyrosine phosphorylation	GO:0050730	108	0.709	Human Mouse
regulation of protein catabolic process	GO:0042176	155	0.706	Human
memory	GO:0007613	3	0.705
cellular amino acid metabolic process	GO:0006520	116	0.692
positive regulation of protein phosphorylation	GO:0001934	313	0.681	Mouse
defense response to other organism	GO:0098542	129	0.675
response to organonitrogen compound	GO:0010243	156	0.675	Human Mouse Rat
response to oxygen containing compound	GO:1901700	369	0.661	Human Mouse Rat
regulation of proteolysis involved in cellular protein catabolic process	GO:1903050	91	0.657	Human
positive regulation of programmed cell death	GO:0043068	249	0.648
negative regulation of protein metabolic process	GO:0051248	391	0.647	Human Mouse
activation of protein kinase activity	GO:0032147	90	0.645	Mouse
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.645
regulation of protein kinase activity	GO:0045859	289	0.639	Human Mouse
growth hormone receptor signaling pathway	GO:0060396	10	0.636	Human
positive regulation of protein kinase activity	GO:0045860	190	0.629	Mouse
negative regulation of developmental process	GO:0051093	247	0.628
response to estrogen	GO:0043627	47	0.626	Human Rat
chromatin organization	GO:0006325	351	0.592
cytokine production	GO:0001816	247	0.585	Mouse
regulation of cell migration	GO:0030334	289	0.580
positive regulation of catabolic process	GO:0009896	310	0.574	Human
peptidyl tyrosine phosphorylation	GO:0018108	170	0.564	Human Mouse
ubiquitin dependent protein catabolic process	GO:0006511	206	0.562	Human
cellular response to organonitrogen compound	GO:0071417	124	0.559	Human Mouse
tube morphogenesis	GO:0035239	95	0.554
positive regulation of sequence specific dna binding transcription factor activity	GO:0051091	131	0.536
intrinsic apoptotic signaling pathway	GO:0097193	127	0.534
modification dependent protein catabolic process	GO:0019941	209	0.532	Human
long term memory	GO:0007616	2	0.531
blastoderm segmentation	GO:0007350	2	0.520
activation of mapk activity	GO:0000187	45	0.516
response to lipid	GO:0033993	206	0.513	Human Rat
positive regulation of peptidase activity	GO:0010952	88	0.511
regulation of immune response	GO:0050776	201	0.510	Zebrafish
positive regulation of cysteine type endopeptidase activity	GO:2001056	79	0.507
regulation of nucleocytoplasmic transport	GO:0046822	98	0.501
regulation of cell differentiation	GO:0045595	393	0.496
cellular protein catabolic process	GO:0044257	261	0.496	Human
negative regulation of cellular amino acid metabolic process	GO:0045763	2	0.491
regulation of hormone levels	GO:0010817	125	0.487
regulation of protein transport	GO:0051223	213	0.487	Mouse
response to cytokine	GO:0034097	232	0.486	Zebrafish Mouse Rat
immune effector process	GO:0002252	159	0.481
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	156	0.470	Human
regulation of peptidase activity	GO:0052547	180	0.469
chromatin modification	GO:0016568	298	0.464
response to abiotic stimulus	GO:0009628	336	0.462
regulation of protein localization	GO:0032880	296	0.452	Mouse
response to peptide hormone	GO:0043434	61	0.452	Human Mouse Rat
peptide secretion	GO:0002790	51	0.449
positive regulation of phosphorylation	GO:0042327	394	0.448	Mouse
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	281	0.442
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	116	0.441
positive regulation of peptidyl tyrosine phosphorylation	GO:0050731	85	0.437
negative regulation of cellular amine metabolic process	GO:0033239	3	0.434
amide transport	GO:0042886	76	0.430
regulation of stress activated mapk cascade	GO:0032872	84	0.428
regulation of jak stat cascade	GO:0046425	44	0.423	Zebrafish Mouse
response to estradiol	GO:0032355	23	0.421	Human Rat
positive regulation of kinase activity	GO:0033674	204	0.413	Mouse
cell adhesion	GO:0007155	325	0.411
positive regulation of mapk cascade	GO:0043410	190	0.407
positive regulation of developmental process	GO:0051094	314	0.403
regulation of tyrosine phosphorylation of stat3 protein	GO:0042516	18	0.403	Mouse
positive regulation of transferase activity	GO:0051347	227	0.395	Mouse
positive regulation of immune system process	GO:0002684	283	0.395
positive regulation of cellular protein catabolic process	GO:1903364	37	0.393	Human
regulation of jnk cascade	GO:0046328	73	0.392
response to nitrogen compound	GO:1901698	184	0.391	Human Mouse Rat
positive regulation of apoptotic process	GO:0043065	246	0.386
regulation of intracellular transport	GO:0032386	195	0.385
positive regulation of tyrosine phosphorylation of stat3 protein	GO:0042517	16	0.382
regulation of mapk cascade	GO:0043408	262	0.372
zymogen activation	GO:0031638	70	0.361
cellular response to peptide	GO:1901653	59	0.360	Human Mouse
regulation of cysteine type endopeptidase activity	GO:2000116	127	0.359
response to peptide	GO:1901652	65	0.355	Human Mouse Rat
response to growth factor	GO:0070848	205	0.352
cellular response to organic cyclic compound	GO:0071407	127	0.349
positive regulation of endopeptidase activity	GO:0010950	84	0.348
cell cell signaling	GO:0007267	155	0.341
positive regulation of cytosolic calcium ion concentration	GO:0007204	82	0.338
reactive oxygen species biosynthetic process	GO:1903409	4	0.335
regulation of proteasomal protein catabolic process	GO:0061136	87	0.331	Human
actin filament based movement	GO:0030048	17	0.330
jnk cascade	GO:0007254	80	0.327
jak stat cascade	GO:0007259	46	0.326	Zebrafish Mouse
tyrosine phosphorylation of stat3 protein	GO:0042503	20	0.326	Mouse
positive regulation of cytokine production	GO:0001819	167	0.319
cellular component morphogenesis	GO:0032989	314	0.314
negative regulation of cellular protein metabolic process	GO:0032269	353	0.306	Human Mouse
positive regulation of stress activated mapk cascade	GO:0032874	60	0.303
response to steroid hormone	GO:0048545	80	0.301	Human Rat
negative regulation of epidermal growth factor activated receptor activity	GO:0007175	6	0.299	Human
stem cell development	GO:0048864	69	0.298
positive regulation of cell differentiation	GO:0045597	211	0.298
negative regulation of cell differentiation	GO:0045596	171	0.297
regulation of cell activation	GO:0050865	125	0.297
negative regulation of multicellular organismal process	GO:0051241	317	0.295
positive regulation of apoptotic signaling pathway	GO:2001235	70	0.293
nuclear import	GO:0051170	106	0.288
response to external biotic stimulus	GO:0043207	261	0.287	Rat
regulation of protein serine threonine kinase activity	GO:0071900	179	0.280
regulation of i kappab kinase nf kappab signaling	GO:0043122	162	0.278
hematopoietic or lymphoid organ development	GO:0048534	186	0.276	Zebrafish
regulation of map kinase activity	GO:0043405	108	0.275
regulation of endopeptidase activity	GO:0052548	170	0.273
positive regulation of map kinase activity	GO:0043406	80	0.273
regulation of cytokine production	GO:0001817	232	0.271	Mouse
regulation of protein targeting	GO:1903533	91	0.268
cellular homeostasis	GO:0019725	196	0.266
activation of cysteine type endopeptidase activity involved in apoptotic process	GO:0006919	49	0.265
cellular response to nitrogen compound	GO:1901699	144	0.262	Human Mouse
cell morphogenesis	GO:0000902	296	0.261
cellular response to interleukin 1	GO:0071347	35	0.255
negative regulation of apoptotic process	GO:0043066	316	0.254
cytosolic calcium ion homeostasis	GO:0051480	89	0.252
regulation of cell adhesion	GO:0030155	166	0.251
negative regulation of striated muscle cell apoptotic process	GO:0010664	2	0.251
positive regulation of cell migration	GO:0030335	172	0.251
covalent chromatin modification	GO:0016569	254	0.250
tyrosine phosphorylation of stat protein	GO:0007260	33	0.250	Mouse
regulation of immune effector process	GO:0002697	91	0.250
system process	GO:0003008	349	0.248
protein maturation	GO:0051604	233	0.248
digestive tract development	GO:0048565	75	0.248
response to organic cyclic compound	GO:0014070	204	0.247	Human Rat
positive regulation of cell death	GO:0010942	263	0.246
negative regulation of protein phosphorylation	GO:0001933	140	0.241	Human Mouse
regulation of cellular protein catabolic process	GO:1903362	96	0.239	Human
regulation of intracellular protein transport	GO:0033157	123	0.238
regulation of cell cycle	GO:0051726	393	0.236
regulation of protein tyrosine kinase activity	GO:0061097	36	0.235	Human
negative regulation of programmed cell death	GO:0043069	321	0.235
regeneration	GO:0031099	4	0.234	Rat
tissue morphogenesis	GO:0048729	96	0.234	Zebrafish
embryonic morphogenesis	GO:0048598	85	0.230
anatomical structure formation involved in morphogenesis	GO:0048646	284	0.228
cell projection organization	GO:0030030	252	0.226
ion homeostasis	GO:0050801	230	0.222
vasculature development	GO:0001944	181	0.221
hemopoiesis	GO:0030097	180	0.221	Zebrafish
regulation of secretion	GO:0051046	194	0.221	Mouse
regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032434	71	0.220	Human
rhythmic behavior	GO:0007622	2	0.217
positive regulation of jnk cascade	GO:0046330	52	0.217
peripheral nervous system development	GO:0007422	2	0.216
leukocyte differentiation	GO:0002521	98	0.215
positive regulation of cell development	GO:0010720	92	0.215
neuron projection regeneration	GO:0031102	1	0.212
tube development	GO:0035295	125	0.212
intracellular protein transport	GO:0006886	270	0.210
intrinsic apoptotic signaling pathway in response to oxidative stress	GO:0008631	21	0.209
regulation of apoptotic signaling pathway	GO:2001233	175	0.209
regulation of locomotion	GO:0040012	329	0.208
positive regulation of cell proliferation	GO:0008284	301	0.207
regulation of cell morphogenesis	GO:0022604	153	0.205
interleukin 2 mediated signaling pathway	GO:0038110	3	0.204
cytoplasmic transport	GO:0016482	379	0.203
regulation of dna metabolic process	GO:0051052	153	0.203
regulation of nervous system development	GO:0051960	88	0.202
negative regulation of cell death	GO:0060548	345	0.202
histone modification	GO:0016570	251	0.201
positive regulation of tyrosine phosphorylation of stat protein	GO:0042531	28	0.201
cell substrate adhesion	GO:0031589	132	0.200
positive regulation of hydrolase activity	GO:0051345	331	0.200
positive regulation of defense response	GO:0031349	87	0.198
neuron differentiation	GO:0030182	138	0.198
regulation of establishment of protein localization	GO:0070201	242	0.198	Mouse
hormone secretion	GO:0046879	65	0.198
ras protein signal transduction	GO:0007265	73	0.197
cellular response to abiotic stimulus	GO:0071214	117	0.195
nervous system development	GO:0007399	293	0.193
motor neuron axon guidance	GO:0008045	2	0.193
cellular response to dna damage stimulus	GO:0006974	379	0.191
cellular divalent inorganic cation homeostasis	GO:0072503	128	0.190
proteasomal protein catabolic process	GO:0010498	176	0.188	Human
phosphatidylinositol mediated signaling	GO:0048015	55	0.186
circadian behavior	GO:0048512	2	0.183
negative regulation of protein modification process	GO:0031400	200	0.182	Human Mouse
immune system development	GO:0002520	195	0.181	Zebrafish
protein catabolic process	GO:0030163	325	0.179	Human
signal transduction by phosphorylation	GO:0023014	297	0.177
cellular response to growth factor stimulus	GO:0071363	197	0.176
cell activation	GO:0001775	213	0.174
negative regulation of peptidyl tyrosine phosphorylation	GO:0050732	20	0.173	Human Mouse
peptide transport	GO:0015833	74	0.172
regulation of dna binding	GO:0051101	37	0.170
negative regulation of phosphate metabolic process	GO:0045936	267	0.168	Human Mouse
chemical homeostasis	GO:0048878	306	0.166
response to biotic stimulus	GO:0009607	276	0.165	Rat
positive regulation of cellular catabolic process	GO:0031331	284	0.164	Human
anterior posterior axis specification	GO:0009948	2	0.163
negative regulation of catalytic activity	GO:0043086	335	0.162	Human Mouse
myeloid cell differentiation	GO:0030099	117	0.161
protein import	GO:0017038	130	0.159
mapk cascade	GO:0000165	288	0.158
mesenchymal cell development	GO:0014031	50	0.156
activation of cysteine type endopeptidase activity	GO:0097202	57	0.156
cellular response to biotic stimulus	GO:0071216	71	0.155
negative regulation of cell development	GO:0010721	48	0.154
negative regulation of phosphorylation	GO:0042326	174	0.154	Human Mouse
innate immune response	GO:0045087	178	0.153	Zebrafish
regionalization	GO:0003002	29	0.151
response to molecule of bacterial origin	GO:0002237	82	0.149	Rat
regulation of anatomical structure morphogenesis	GO:0022603	286	0.148
generation of neurons	GO:0048699	152	0.145
positive regulation of cytoplasmic transport	GO:1903651	82	0.144
positive regulation of organelle organization	GO:0010638	195	0.143
female gamete generation	GO:0007292	2	0.142
stress activated protein kinase signaling cascade	GO:0031098	94	0.142
response to growth hormone	GO:0060416	11	0.142	Human
proteolysis involved in cellular protein catabolic process	GO:0051603	244	0.142	Human
organonitrogen compound biosynthetic process	GO:1901566	200	0.141
regulation of protein processing	GO:0070613	150	0.140
protein autophosphorylation	GO:0046777	123	0.139
regulation of protein localization to nucleus	GO:1900180	85	0.139
regulation of defense response	GO:0031347	154	0.139	Zebrafish
stress activated mapk cascade	GO:0051403	93	0.138
regulation of erbb signaling pathway	GO:1901184	27	0.137	Human
compound eye development	GO:0048749	1	0.136
regulation of reactive oxygen species metabolic process	GO:2000377	41	0.136
cellular response to hydrogen peroxide	GO:0070301	37	0.135
positive regulation of protein catabolic process	GO:0045732	75	0.134	Human
regulation of cellular component movement	GO:0051270	334	0.132
regulation of neurogenesis	GO:0050767	82	0.132
regulation of chromosome organization	GO:0033044	103	0.132
positive regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway	GO:2001269	1	0.132
axon regeneration	GO:0031103	1	0.131
negative regulation of intracellular signal transduction	GO:1902532	183	0.131	Zebrafish Mouse
gland development	GO:0048732	48	0.130
locomotory behavior	GO:0007626	1	0.130
cellular metal ion homeostasis	GO:0006875	146	0.129
cellular response to interleukin 12	GO:0071349	3	0.129
regulation of cell development	GO:0060284	161	0.129
negative regulation of cell proliferation	GO:0008285	228	0.129
morphogenesis of an epithelium	GO:0002009	60	0.127
positive regulation of reactive oxygen species biosynthetic process	GO:1903428	2	0.125
regulation of nucleoside metabolic process	GO:0009118	209	0.124
biological adhesion	GO:0022610	331	0.124
establishment of protein localization to organelle	GO:0072594	172	0.123
regulation of erk1 and erk2 cascade	GO:0070372	99	0.122
protein ubiquitination	GO:0016567	314	0.121
negative regulation of immune system process	GO:0002683	136	0.120	Zebrafish
blood vessel development	GO:0001568	172	0.119
positive regulation of reactive oxygen species metabolic process	GO:2000379	24	0.116
response to corticosteroid	GO:0031960	15	0.116
positive regulation of binding	GO:0051099	45	0.115
negative regulation of protein maturation	GO:1903318	142	0.115
cardiovascular system development	GO:0072358	262	0.115
circulatory system process	GO:0003013	113	0.114
regulation of meiotic cell cycle	GO:0051445	4	0.114
cellular response to glucocorticoid stimulus	GO:0071385	4	0.113
positive regulation of transport	GO:0051050	336	0.113
single organism cellular localization	GO:1902580	332	0.113
positive regulation of stress activated protein kinase signaling cascade	GO:0070304	61	0.112
erk1 and erk2 cascade	GO:0070371	104	0.111
response to hypoxia	GO:0001666	96	0.111
regulation of innate immune response	GO:0045088	97	0.110	Zebrafish
gastrulation	GO:0007369	51	0.109
regulation of cellular component biogenesis	GO:0044087	281	0.108
circulatory system development	GO:0072359	262	0.108
intracellular receptor signaling pathway	GO:0030522	104	0.106
negative regulation of cell cycle	GO:0045786	193	0.106
negative regulation of nf kappab transcription factor activity	GO:0032088	51	0.104
negative regulation of jak stat cascade	GO:0046426	4	0.104	Zebrafish Mouse
negative regulation of phosphorus metabolic process	GO:0010563	267	0.104	Human Mouse
neuron projection development	GO:0031175	106	0.104
regulation of protein maturation	GO:1903317	150	0.104
regulation of stress activated protein kinase signaling cascade	GO:0070302	85	0.103
regulation of peptide transport	GO:0090087	62	0.103
response to virus	GO:0009615	126	0.103
i kappab kinase nf kappab signaling	GO:0007249	166	0.102
hypoxia inducible factor 1alpha signaling pathway	GO:0097411	3	0.101
apoptotic signaling pathway	GO:0097190	268	0.101
regulation of secretion by cell	GO:1903530	177	0.100	Mouse
regulation of tyrosine phosphorylation of stat protein	GO:0042509	30	0.100	Mouse
amide biosynthetic process	GO:0043604	15	0.100
mesenchyme development	GO:0060485	59	0.099
positive regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032436	30	0.099	Human
regulation of canonical wnt signaling pathway	GO:0060828	88	0.099
blood vessel morphogenesis	GO:0048514	162	0.098
protein targeting	GO:0006605	187	0.095
canonical wnt signaling pathway	GO:0060070	116	0.094
regulation of cell motility	GO:2000145	299	0.094
positive regulation of protein transport	GO:0051222	135	0.094
epithelium migration	GO:0090132	119	0.093
microtubule based process	GO:0007017	210	0.093
negative regulation of protein kinase activity	GO:0006469	98	0.092	Human
protein localization to nucleus	GO:0034504	136	0.091
interleukin 1 production	GO:0032612	26	0.090
cellular response to interleukin 15	GO:0071350	6	0.090
positive regulation of nitric oxide synthase biosynthetic process	GO:0051770	3	0.089
inositol lipid mediated signaling	GO:0048017	55	0.089
regulation of protein import into nucleus	GO:0042306	78	0.088
response to alcohol	GO:0097305	64	0.088	Human Rat
mesenchymal cell differentiation	GO:0048762	52	0.088
metal ion homeostasis	GO:0055065	169	0.087
negative regulation of transport	GO:0051051	176	0.086
regulation of cell cycle process	GO:0010564	266	0.086
regulation of epidermal growth factor activated receptor activity	GO:0007176	14	0.086	Human
cell morphogenesis involved in differentiation	GO:0000904	144	0.086
positive regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043280	69	0.085
sex determination	GO:0007530	3	0.085
protein import into nucleus	GO:0006606	104	0.085
regulation of lipid metabolic process	GO:0019216	96	0.083
positive regulation of phosphatidylinositol 3 kinase signaling	GO:0014068	28	0.083
negative regulation of protein processing	GO:0010955	142	0.083
negative regulation of binding	GO:0051100	57	0.082
regulation of tumor necrosis factor production	GO:0032680	43	0.082
regulation of ossification	GO:0030278	58	0.082
regulation of protein ubiquitination	GO:0031396	95	0.081
epithelial cell migration	GO:0010631	119	0.081
mitotic cell cycle	GO:0000278	326	0.081
neurological system process	GO:0050877	163	0.079
positive regulation of protein serine threonine kinase activity	GO:0071902	119	0.079
taxis	GO:0042330	157	0.079
response to decreased oxygen levels	GO:0036293	96	0.079
regulation of binding	GO:0051098	111	0.079
actin filament based process	GO:0030029	224	0.079
nitrogen compound transport	GO:0071705	191	0.077
gtp catabolic process	GO:0006184	237	0.077
leukocyte activation	GO:0045321	164	0.077
cellular response to oxidative stress	GO:0034599	85	0.076
regulation of cellular response to growth factor stimulus	GO:0090287	76	0.076
positive regulation of lipid metabolic process	GO:0045834	50	0.076
insulin secretion	GO:0030073	39	0.076
associative learning	GO:0008306	1	0.076
sensory perception of pain	GO:0019233	4	0.074
regulation of tumor necrosis factor superfamily cytokine production	GO:1903555	44	0.074
growth	GO:0040007	202	0.074
neurogenesis	GO:0022008	169	0.074
extrinsic apoptotic signaling pathway	GO:0097191	119	0.073
response to ionizing radiation	GO:0010212	65	0.073
cell type specific apoptotic process	GO:0097285	125	0.073
immune response regulating signaling pathway	GO:0002764	97	0.073
cellular response to lipid	GO:0071396	127	0.071
actin cytoskeleton organization	GO:0030036	207	0.071
regulation of insulin secretion	GO:0050796	33	0.071
protein import into nucleus translocation	GO:0000060	22	0.071
positive regulation of cell motility	GO:2000147	177	0.070
protein alkylation	GO:0008213	74	0.070
positive regulation of cell adhesion	GO:0045785	84	0.070
posttranscriptional regulation of gene expression	GO:0010608	213	0.069
negative regulation of epidermal growth factor receptor signaling pathway	GO:0042059	11	0.069	Human
negative regulation of vasculature development	GO:1901343	43	0.068
positive regulation of cell cycle	GO:0045787	140	0.068
positive regulation of intracellular protein transport	GO:0090316	76	0.068
positive regulation of secretion	GO:0051047	116	0.067
organ morphogenesis	GO:0009887	147	0.067	Zebrafish
formation of primary germ layer	GO:0001704	42	0.066
reactive nitrogen species metabolic process	GO:2001057	3	0.066
hormone transport	GO:0009914	68	0.066
cell cycle phase transition	GO:0044770	173	0.066
immune response activating signal transduction	GO:0002757	90	0.065
hair cell differentiation	GO:0035315	2	0.065
single organismal cell cell adhesion	GO:0016337	148	0.065
negative regulation of defense response	GO:0031348	47	0.065	Zebrafish
regulation of cytoplasmic transport	GO:1903649	149	0.065
response to other organism	GO:0051707	261	0.065	Rat
cellular response to lipopolysaccharide	GO:0071222	57	0.065
protein targeting to nucleus	GO:0044744	104	0.064
digestive system development	GO:0055123	75	0.064
anterior posterior axis specification embryo	GO:0008595	2	0.062
epithelial cell proliferation	GO:0050673	128	0.062
response to dexamethasone	GO:0071548	1	0.062
cellular response to decreased oxygen levels	GO:0036294	51	0.060
cell division	GO:0051301	168	0.059
positive regulation of locomotion	GO:0040017	186	0.059
negative regulation of cardiac muscle cell apoptotic process	GO:0010667	2	0.059
cellular response to tumor necrosis factor	GO:0071356	63	0.058
positive regulation of dna binding	GO:0043388	17	0.058
regulation of cell cycle arrest	GO:0071156	36	0.058
reproductive process	GO:0022414	106	0.057
interleukin 12 mediated signaling pathway	GO:0035722	3	0.057
positive regulation of proteolysis involved in cellular protein catabolic process	GO:1903052	35	0.057	Human
translation	GO:0006412	132	0.057
muscle cell proliferation	GO:0033002	35	0.057
convergent extension involved in gastrulation	GO:0060027	1	0.057
negative regulation of stem cell differentiation	GO:2000737	22	0.056
ribonucleoside triphosphate metabolic process	GO:0009199	412	0.056
epithelial to mesenchymal transition	GO:0001837	48	0.056
tumor necrosis factor production	GO:0032640	43	0.056
regulation of nucleotide metabolic process	GO:0006140	269	0.056
g protein coupled receptor signaling pathway	GO:0007186	207	0.056
interleukin 13 secretion	GO:0072611	2	0.055
signal release	GO:0023061	70	0.055
negative regulation of wnt signaling pathway	GO:0030178	69	0.054
positive regulation of insulin secretion	GO:0032024	10	0.054
response to axon injury	GO:0048678	1	0.053
neuromuscular junction development	GO:0007528	3	0.053
positive regulation of interleukin 1 beta production	GO:0032731	13	0.053
positive regulation of secretion by cell	GO:1903532	108	0.053
secretion by cell	GO:0032940	226	0.053	Mouse
protein processing	GO:0016485	226	0.053
microtubule cytoskeleton organization	GO:0000226	176	0.053
phosphatidylinositol 3 kinase signaling	GO:0014065	48	0.052
mitotic cell cycle process	GO:1903047	286	0.052
cell migration involved in gastrulation	GO:0042074	1	0.052
regulation of myeloid cell differentiation	GO:0045637	81	0.052
tissue migration	GO:0090130	119	0.052
oogenesis	GO:0048477	2	0.052
cellular chemical homeostasis	GO:0055082	180	0.051
response to fungus	GO:0009620	4	0.051
glucose homeostasis	GO:0042593	31	0.051
response to lipopolysaccharide	GO:0032496	70	0.050	Rat
negative regulation of peptidase activity	GO:0010466	91	0.050
immune response	GO:0006955	307	0.050	Zebrafish
regulation of epithelial cell proliferation	GO:0050678	113	0.049
positive regulation of tyrosine phosphorylation of stat5 protein	GO:0042523	11	0.049
nucleocytoplasmic transport	GO:0006913	176	0.049
positive regulation of nucleocytoplasmic transport	GO:0046824	54	0.049
regulation of body fluid levels	GO:0050878	99	0.049
negative regulation of protein serine threonine kinase activity	GO:0071901	57	0.049
positive regulation of intracellular transport	GO:0032388	104	0.049
response to drug	GO:0042493	81	0.049	Rat
cellular response to hypoxia	GO:0071456	51	0.048
response to interleukin 15	GO:0070672	6	0.048
pattern specification process	GO:0007389	43	0.048
sensory organ development	GO:0007423	52	0.048	Zebrafish
intracellular steroid hormone receptor signaling pathway	GO:0030518	61	0.048
cellular response to oxygen levels	GO:0071453	55	0.048
transforming growth factor beta receptor signaling pathway	GO:0007179	76	0.048
negative regulation of cellular component movement	GO:0051271	106	0.048
negative regulation of intracellular transport	GO:0032387	60	0.047
histone lysine methylation	GO:0034968	50	0.047
positive regulation of cell cycle process	GO:0090068	106	0.047
convergent extension	GO:0060026	1	0.047
cellular response to dexamethasone stimulus	GO:0071549	1	0.047
regulation of endothelial cell proliferation	GO:0001936	56	0.047
cellular response to molecule of bacterial origin	GO:0071219	62	0.046
response to tumor necrosis factor	GO:0034612	76	0.046
regulation of chromatin modification	GO:1903308	51	0.046
dna repair	GO:0006281	198	0.046
negative regulation of cytokine production	GO:0001818	82	0.046
protein modification by small protein conjugation	GO:0032446	342	0.046
lipid metabolic process	GO:0006629	381	0.045
interleukin 1 beta production	GO:0032611	22	0.045
positive regulation of tumor necrosis factor superfamily cytokine production	GO:1903557	22	0.045
histone methylation	GO:0016571	60	0.045
osteoblast differentiation	GO:0001649	92	0.045
negative regulation of hydrolase activity	GO:0051346	182	0.044
dna replication	GO:0006260	116	0.044
actin filament organization	GO:0007015	128	0.044
copper ion homeostasis	GO:0055070	3	0.044
positive regulation of erk1 and erk2 cascade	GO:0070374	75	0.044
response to radiation	GO:0009314	151	0.044
response to oxidative stress	GO:0006979	121	0.043
tripartite regional subdivision	GO:0007351	2	0.042
positive regulation of cellular component movement	GO:0051272	181	0.042
negative regulation of lipid metabolic process	GO:0045833	38	0.042
reactive oxygen species metabolic process	GO:0072593	75	0.042
defense response to fungus	GO:0050832	4	0.042
eye development	GO:0001654	42	0.042	Zebrafish
positive regulation of endothelial cell migration	GO:0010595	39	0.041
regulation of cell shape	GO:0008360	48	0.041
activation of mapkk activity	GO:0000186	18	0.041
regulation of mitotic cell cycle	GO:0007346	189	0.040
regulation of wnt signaling pathway	GO:0030111	123	0.040

SOCS1 disease predictions

Disease	DO term ID	Size	Probability
immune system disease	DOID:2914	155	0.123
cancer	DOID:162	167	0.095
disease of cellular proliferation	DOID:14566	174	0.095
organ system cancer	DOID:0050686	164	0.095
musculoskeletal system disease	DOID:17	223	0.041

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