IMP: Integrative Multi-species Prediction

Homo sapiens

73 known processes

SRPK1

SRSF protein kinase 1

(Aliases: SFRSK1)

Entrez: 6732
Ensembl: ENSG00000096063
HPRD: 15992
HGNC: 11305
MIM: 601939
UniProtKB: Q96SB4

Process Predictions
Disease Predictions

SRPK1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
mrna metabolic process	GO:0016071	175	1.000
rna splicing via transesterification reactions	GO:0000375	90	0.999	Human Yeast
mrna splicing via spliceosome	GO:0000398	89	0.999	Human Yeast
mrna processing	GO:0006397	133	0.999
regulation of mrna metabolic process	GO:1903311	53	0.998
rna processing	GO:0006396	255	0.994
nuclear division	GO:0000280	128	0.989	Fly
post embryonic development	GO:0009791	2	0.979	Worm
rna splicing	GO:0008380	131	0.956	Human Yeast
rna splicing via transesterification reactions with bulged adenosine as nucleophile	GO:0000377	89	0.954	Human Yeast
ras protein signal transduction	GO:0007265	73	0.933
purine containing compound catabolic process	GO:0072523	411	0.919
regulation of rna splicing	GO:0043484	62	0.907
regulation of mrna splicing via spliceosome	GO:0048024	32	0.883
mrna splice site selection	GO:0006376	7	0.862	Yeast
organelle fission	GO:0048285	149	0.830	Fly
single organism cellular localization	GO:1902580	332	0.819	Yeast
embryo development	GO:0009790	123	0.716	Zebrafish Worm
reproductive process	GO:0022414	106	0.711	Worm Fly
ribonucleoprotein complex biogenesis	GO:0022613	116	0.705	Human Yeast
spliceosomal complex assembly	GO:0000245	17	0.703	Human Yeast
small gtpase mediated signal transduction	GO:0007264	78	0.649
negative regulation of viral genome replication	GO:0045071	35	0.637
regulation of mrna processing	GO:0050684	48	0.636
intracellular protein transport	GO:0006886	270	0.622	Yeast
regulation of small gtpase mediated signal transduction	GO:0051056	156	0.596
microtubule cytoskeleton organization	GO:0000226	176	0.589	Fly
cytokinesis	GO:0000910	96	0.579	Worm
cellular macromolecular complex assembly	GO:0034622	324	0.529	Human Yeast
defense response to bacterium	GO:0042742	63	0.519
regulation of ras protein signal transduction	GO:0046578	155	0.512
nuclear import	GO:0051170	106	0.507	Yeast
establishment of protein localization to organelle	GO:0072594	172	0.497	Yeast
negative regulation of phosphorus metabolic process	GO:0010563	267	0.481
ribonucleoprotein complex assembly	GO:0022618	78	0.471	Human Yeast
chromosome segregation	GO:0007059	114	0.457
regulation of alternative mrna splicing via spliceosome	GO:0000381	22	0.452
nucleoside catabolic process	GO:0009164	408	0.438
sex differentiation	GO:0007548	45	0.422	Worm
female sex determination	GO:0030237	1	0.420
tube development	GO:0035295	125	0.403
female gamete generation	GO:0007292	2	0.401	Worm Fly
protein targeting to nucleus	GO:0044744	104	0.398	Yeast
gtp metabolic process	GO:0046039	239	0.383
meiotic nuclear division	GO:0007126	10	0.374	Fly
response to bacterium	GO:0009617	144	0.369
rna catabolic process	GO:0006401	71	0.369
positive regulation of mrna metabolic process	GO:1903313	19	0.367
ribonucleotide catabolic process	GO:0009261	405	0.366
establishment or maintenance of cytoskeleton polarity	GO:0030952	3	0.347
negative regulation of phosphate metabolic process	GO:0045936	267	0.337
regulation of cellular component biogenesis	GO:0044087	281	0.334
response to biotic stimulus	GO:0009607	276	0.333
cell development	GO:0048468	328	0.323	Worm Fly
response to drug	GO:0042493	81	0.314	Yeast
protein localization to nucleus	GO:0034504	136	0.295	Yeast
cellular amine metabolic process	GO:0044106	41	0.295
sex determination	GO:0007530	3	0.290
regulation of cell cycle	GO:0051726	393	0.288	Worm
guanosine containing compound metabolic process	GO:1901068	244	0.272
positive regulation of cellular catabolic process	GO:0031331	284	0.266
purine ribonucleoside metabolic process	GO:0046128	437	0.255
microtubule based process	GO:0007017	210	0.254	Fly
cell division	GO:0051301	168	0.250	Zebrafish Worm
regulation of oocyte development	GO:0060281	1	0.243
positive regulation of intracellular protein transport	GO:0090316	76	0.239	Yeast
regulation of mapk cascade	GO:0043408	262	0.238
nuclear transport	GO:0051169	179	0.236	Yeast
nucleoside triphosphate catabolic process	GO:0009143	394	0.228
guanosine containing compound catabolic process	GO:1901069	239	0.228
negative regulation of mrna splicing via spliceosome	GO:0048025	11	0.227
signal transduction by phosphorylation	GO:0023014	297	0.225	Zebrafish
ribonucleoside triphosphate catabolic process	GO:0009203	391	0.210
purine nucleoside catabolic process	GO:0006152	398	0.204
hemopoiesis	GO:0030097	180	0.196
response to external biotic stimulus	GO:0043207	261	0.179
positive regulation of catabolic process	GO:0009896	310	0.173
meiotic cell cycle	GO:0051321	13	0.173	Worm Fly
regulation of meiotic cell cycle	GO:0051445	4	0.172	Worm
embryo development ending in birth or egg hatching	GO:0009792	34	0.169	Zebrafish Worm
defense response	GO:0006952	315	0.168
defense response to other organism	GO:0098542	129	0.167
regulation of protein serine threonine kinase activity	GO:0071900	179	0.166
regulation of viral process	GO:0050792	103	0.166
cellular homeostasis	GO:0019725	196	0.163	Yeast
posttranscriptional regulation of gene expression	GO:0010608	213	0.162	Zebrafish
ribonucleoside triphosphate metabolic process	GO:0009199	412	0.154
protein autophosphorylation	GO:0046777	123	0.154
reproduction	GO:0000003	63	0.152	Worm Fly
regulation of protein kinase activity	GO:0045859	289	0.151
positive regulation of apoptotic process	GO:0043065	246	0.150
immune system development	GO:0002520	195	0.148
oogenesis	GO:0048477	2	0.146	Worm Fly
hematopoietic or lymphoid organ development	GO:0048534	186	0.146
positive regulation of cell death	GO:0010942	263	0.145
positive regulation of phosphorylation	GO:0042327	394	0.144
purine nucleoside triphosphate catabolic process	GO:0009146	392	0.144
erk1 and erk2 cascade	GO:0070371	104	0.143
regulation of cell development	GO:0060284	161	0.138
intracellular mrna localization	GO:0008298	1	0.133
positive regulation of ras gtpase activity	GO:0032320	117	0.131
establishment of organelle localization	GO:0051656	59	0.129
peptidyl serine phosphorylation	GO:0018105	101	0.126
negative regulation of mrna processing	GO:0050686	12	0.123
gtp catabolic process	GO:0006184	237	0.121
regulation of nucleoside metabolic process	GO:0009118	209	0.119
regulation of rho protein signal transduction	GO:0035023	79	0.118
maintenance of location	GO:0051235	112	0.117
rho protein signal transduction	GO:0007266	26	0.114
ion homeostasis	GO:0050801	230	0.113	Yeast
regulation of viral genome replication	GO:0045069	48	0.109
meiotic chromosome segregation	GO:0045132	4	0.109
purine nucleoside triphosphate metabolic process	GO:0009144	412	0.104
regulation of anatomical structure size	GO:0090066	101	0.103	Yeast
organelle localization	GO:0051640	84	0.103
mrna catabolic process	GO:0006402	56	0.096
nucleoside triphosphate metabolic process	GO:0009141	422	0.095
single organism nuclear import	GO:1902593	104	0.093	Yeast
regulation of transferase activity	GO:0051338	355	0.091
positive regulation of meiotic cell cycle	GO:0051446	2	0.089	Worm
negative regulation of protein metabolic process	GO:0051248	391	0.089
lipid biosynthetic process	GO:0008610	177	0.083
regulation of translation	GO:0006417	89	0.082
viral genome replication	GO:0019079	50	0.082
regulation of cellular component size	GO:0032535	82	0.081	Yeast
regulation of ras gtpase activity	GO:0032318	128	0.080
positive regulation of multi organism process	GO:0043902	56	0.079
regulation of cytoplasmic transport	GO:1903649	149	0.078	Yeast
regulation of nucleotide catabolic process	GO:0030811	205	0.076
dna replication	GO:0006260	116	0.073
regulation of cellular response to stress	GO:0080135	244	0.073
positive regulation of defense response	GO:0031349	87	0.072
negative regulation of catalytic activity	GO:0043086	335	0.071
regulation of defense response	GO:0031347	154	0.071
regulation of protein transport	GO:0051223	213	0.071	Yeast
viral process	GO:0016032	146	0.070
single organism reproductive process	GO:0044702	98	0.069	Worm Fly
cellular macromolecule catabolic process	GO:0044265	380	0.069
positive regulation of programmed cell death	GO:0043068	249	0.068
negative regulation of cell cycle	GO:0045786	193	0.068	Worm
multicellular organism reproduction	GO:0032504	42	0.068	Worm Fly
negative regulation of cellular protein metabolic process	GO:0032269	353	0.066
response to abiotic stimulus	GO:0009628	336	0.065
response to other organism	GO:0051707	261	0.064
positive regulation of immune response	GO:0050778	159	0.064
positive regulation of protein transport	GO:0051222	135	0.062	Yeast
regulation of purine nucleotide catabolic process	GO:0033121	205	0.062
peptidyl serine modification	GO:0018209	106	0.062
regulation of response to wounding	GO:1903034	101	0.061
alternative mrna splicing via spliceosome	GO:0000380	27	0.061
regulation of protein import into nucleus	GO:0042306	78	0.060	Yeast
lipid metabolic process	GO:0006629	381	0.059
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	181	0.059
regulation of rho gtpase activity	GO:0032319	66	0.059
determination of adult lifespan	GO:0008340	2	0.057
regulation of anatomical structure morphogenesis	GO:0022603	286	0.056
reproductive structure development	GO:0048608	55	0.056	Worm
segmentation	GO:0035282	4	0.055	Zebrafish
viral life cycle	GO:0019058	132	0.054
cellular ion homeostasis	GO:0006873	168	0.054	Yeast
regulation of cell differentiation	GO:0045595	393	0.054
endocytosis	GO:0006897	159	0.053
mapk cascade	GO:0000165	288	0.053	Zebrafish
cellular response to dna damage stimulus	GO:0006974	379	0.052
negative regulation of multi organism process	GO:0043901	92	0.052
ribonucleoprotein complex subunit organization	GO:0071826	81	0.052	Human Yeast
spindle organization	GO:0007051	53	0.051	Fly
positive regulation of mapk cascade	GO:0043410	190	0.051
organelle assembly	GO:0070925	176	0.051	Fly
translation	GO:0006412	132	0.051
regulation of kinase activity	GO:0043549	314	0.050
positive regulation of viral process	GO:0048524	37	0.050
positive regulation of nucleotide catabolic process	GO:0030813	185	0.050
purine nucleotide catabolic process	GO:0006195	405	0.049
gene silencing	GO:0016458	49	0.048
positive regulation of epithelial cell proliferation involved in lung morphogenesis	GO:0060501	2	0.047
negative regulation of rna splicing	GO:0033119	15	0.046
amine metabolic process	GO:0009308	44	0.046
myeloid cell differentiation	GO:0030099	117	0.045
regulation of autophagy	GO:0010506	52	0.045
developmental process involved in reproduction	GO:0003006	66	0.045	Worm Fly
mitotic cell cycle	GO:0000278	326	0.045	Worm
negative regulation of protein serine threonine kinase activity	GO:0071901	57	0.045
mrna 5 splice site recognition	GO:0000395	3	0.045
positive regulation of transferase activity	GO:0051347	227	0.044
positive regulation of mrna processing	GO:0050685	17	0.044
central nervous system development	GO:0007417	123	0.043
regulation of dna metabolic process	GO:0051052	153	0.042
oocyte development	GO:0048599	1	0.042
cytoplasmic transport	GO:0016482	379	0.042	Yeast
regeneration	GO:0031099	4	0.040
regulation of intracellular transport	GO:0032386	195	0.040	Yeast
growth	GO:0040007	202	0.040
regulation of erk1 and erk2 cascade	GO:0070372	99	0.039
gonad development	GO:0008406	34	0.039	Worm
protein import	GO:0017038	130	0.039	Yeast
glycerophospholipid metabolic process	GO:0006650	84	0.039
purine ribonucleoside triphosphate catabolic process	GO:0009207	391	0.038
oocyte differentiation	GO:0009994	2	0.038
positive regulation of immune system process	GO:0002684	283	0.038
single organism membrane organization	GO:0044802	268	0.038
response to ionizing radiation	GO:0010212	65	0.037
regulation of cell cycle process	GO:0010564	266	0.036
jnk cascade	GO:0007254	80	0.036
protein targeting	GO:0006605	187	0.035	Yeast
regulation of microtubule based process	GO:0032886	74	0.034
regulation of purine nucleotide metabolic process	GO:1900542	264	0.034
histone modification	GO:0016570	251	0.034
positive regulation of purine nucleotide catabolic process	GO:0033123	185	0.034
regulation of gene expression epigenetic	GO:0040029	73	0.034
multicellular organismal aging	GO:0010259	3	0.033
genitalia development	GO:0048806	10	0.033	Worm
purine ribonucleoside catabolic process	GO:0046130	398	0.033
positive regulation of nucleoside metabolic process	GO:0045979	186	0.032
positive regulation of nucleotide metabolic process	GO:0045981	230	0.032
positive regulation of protein phosphorylation	GO:0001934	313	0.031
positive regulation of intracellular transport	GO:0032388	104	0.031	Yeast
regulation of cell morphogenesis	GO:0022604	153	0.031
lung development	GO:0030324	20	0.031
chromatin modification	GO:0016568	298	0.031
negative regulation of protein modification process	GO:0031400	200	0.031
protein localization to organelle	GO:0033365	280	0.031	Yeast
chordate embryonic development	GO:0043009	34	0.031	Zebrafish
behavior	GO:0007610	112	0.030
purine ribonucleoside triphosphate metabolic process	GO:0009205	411	0.029
regulation of cell size	GO:0008361	19	0.029	Yeast
protein catabolic process	GO:0030163	325	0.029
apoptotic signaling pathway	GO:0097190	268	0.029
organ morphogenesis	GO:0009887	147	0.028
negative regulation of mrna metabolic process	GO:1903312	15	0.028
protein oligomerization	GO:0051259	173	0.028
cellular response to hormone stimulus	GO:0032870	125	0.028
positive regulation of transport	GO:0051050	336	0.028	Yeast
metal ion transport	GO:0030001	272	0.027
regulation of nucleocytoplasmic transport	GO:0046822	98	0.027	Yeast
ribonucleoside catabolic process	GO:0042454	406	0.027
positive regulation of gtp catabolic process	GO:0033126	166	0.026
regulation of nucleotide metabolic process	GO:0006140	269	0.026
positive regulation of cell proliferation	GO:0008284	301	0.025	Human
positive regulation of nucleocytoplasmic transport	GO:0046824	54	0.025	Yeast
positive regulation of erk1 and erk2 cascade	GO:0070374	75	0.025
multi organism reproductive process	GO:0044703	54	0.024	Worm Fly
ribosome biogenesis	GO:0042254	48	0.024
positive regulation of cellular component organization	GO:0051130	376	0.023
blastocyst development	GO:0001824	3	0.023
microtubule nucleation	GO:0007020	6	0.023
regulation of innate immune response	GO:0045088	97	0.023
cellular cation homeostasis	GO:0030003	163	0.022	Yeast
chromatin organization	GO:0006325	351	0.022
regulation of cell division	GO:0051302	116	0.022
signal transduction by p53 class mediator	GO:0072331	72	0.022
nucleoside phosphate catabolic process	GO:1901292	412	0.021
receptor mediated endocytosis	GO:0006898	84	0.021
blood vessel development	GO:0001568	172	0.021
microtubule polymerization or depolymerization	GO:0031109	37	0.021
anterior posterior axis specification embryo	GO:0008595	2	0.021
positive regulation of nfat protein import into nucleus	GO:0051533	3	0.020
negative regulation of protein phosphorylation	GO:0001933	140	0.020
positive regulation of translation	GO:0045727	35	0.020
purine ribonucleotide catabolic process	GO:0009154	404	0.020
positive regulation of protein localization to nucleus	GO:1900182	48	0.020	Yeast
peptidyl tyrosine phosphorylation	GO:0018108	170	0.020
reproductive system development	GO:0061458	56	0.019	Worm
posttranscriptional gene silencing by rna	GO:0035194	25	0.019
transmembrane transport	GO:0055085	399	0.019
regulation of stress activated mapk cascade	GO:0032872	84	0.019
nfat protein import into nucleus	GO:0051531	5	0.019
cellular response to nitrogen compound	GO:1901699	144	0.019
sexual reproduction	GO:0019953	37	0.019	Worm Fly
regulation of growth	GO:0040008	165	0.018
t cell activation	GO:0042110	99	0.018
glycosyl compound catabolic process	GO:1901658	413	0.018
cellular component disassembly	GO:0022411	92	0.018
regulation of protein localization to nucleus	GO:1900180	85	0.017	Yeast
innate immune response	GO:0045087	178	0.017
cation homeostasis	GO:0055080	189	0.017	Yeast
positive regulation of cellular component biogenesis	GO:0044089	158	0.017
multicellular organismal reproductive process	GO:0048609	40	0.017	Worm Fly
brain development	GO:0007420	97	0.017
regulation of cellular amino acid metabolic process	GO:0006521	6	0.017
negative regulation of epidermis development	GO:0045683	5	0.016
regulation of cellular ketone metabolic process	GO:0010565	50	0.016
regulation of protein modification by small protein conjugation or removal	GO:1903320	107	0.016
rrna processing	GO:0006364	35	0.016
positive regulation of rho gtpase activity	GO:0032321	56	0.016
immune response regulating signaling pathway	GO:0002764	97	0.016
cellular chemical homeostasis	GO:0055082	180	0.016	Yeast
regulation of stress activated protein kinase signaling cascade	GO:0070302	85	0.016
positive regulation of hydrolase activity	GO:0051345	331	0.016
regulation of meiosis	GO:0040020	3	0.016
vesicle mediated transport	GO:0016192	371	0.015
regulation of protein ubiquitination	GO:0031396	95	0.015
vasculature development	GO:0001944	181	0.015
lung epithelium development	GO:0060428	7	0.015
respiratory system development	GO:0060541	22	0.015
synaptic transmission	GO:0007268	61	0.015
development of primary sexual characteristics	GO:0045137	35	0.015	Worm
establishment of protein localization to membrane	GO:0090150	121	0.015
digestive system development	GO:0055123	75	0.015
response to radiation	GO:0009314	151	0.015
tripartite regional subdivision	GO:0007351	2	0.015
negative regulation of kinase activity	GO:0033673	106	0.014
blastoderm segmentation	GO:0007350	2	0.014
negative regulation of cellular component organization	GO:0051129	235	0.014
mitotic sister chromatid segregation	GO:0000070	53	0.014
gene silencing by rna	GO:0031047	26	0.013
regulation of symbiosis encompassing mutualism through parasitism	GO:0043903	109	0.013
t cell differentiation in thymus	GO:0033077	4	0.013
negative regulation of hydrolase activity	GO:0051346	182	0.013
nucleotide catabolic process	GO:0009166	408	0.013
negative regulation of protein kinase activity	GO:0006469	98	0.013
nervous system development	GO:0007399	293	0.013
erythrocyte differentiation	GO:0030218	28	0.013
autophagy	GO:0006914	88	0.013
regulation of gtp catabolic process	GO:0033124	180	0.013
cell morphogenesis	GO:0000902	296	0.013
gamete generation	GO:0007276	25	0.013	Worm Fly
negative regulation of phosphorylation	GO:0042326	174	0.013
stress activated protein kinase signaling cascade	GO:0031098	94	0.012
negative regulation of intracellular signal transduction	GO:1902532	183	0.012
cytokine production	GO:0001816	247	0.012
phospholipid metabolic process	GO:0006644	99	0.012
tube morphogenesis	GO:0035239	95	0.012
response to oxidative stress	GO:0006979	121	0.012
stress activated mapk cascade	GO:0051403	93	0.012
blood vessel morphogenesis	GO:0048514	162	0.012
cell projection organization	GO:0030030	252	0.012
intrinsic apoptotic signaling pathway	GO:0097193	127	0.012
regulation of protein acetylation	GO:1901983	25	0.011
ncrna processing	GO:0034470	83	0.011
protein import into nucleus	GO:0006606	104	0.011	Yeast
immune response activating signal transduction	GO:0002757	90	0.011
regulation of histone modification	GO:0031056	47	0.011
vesicle organization	GO:0016050	62	0.011
peptidyl tyrosine modification	GO:0018212	170	0.011
positive regulation of innate immune response	GO:0045089	79	0.011
enzyme linked receptor protein signaling pathway	GO:0007167	303	0.011
epithelium development	GO:0060429	227	0.011	Zebrafish
cation transport	GO:0006812	331	0.010
aging	GO:0007568	66	0.010
positive regulation of cell cycle	GO:0045787	140	0.010	Worm
cellular amino acid metabolic process	GO:0006520	116	0.010
cell cell junction organization	GO:0045216	69	0.010
small molecule biosynthetic process	GO:0044283	157	0.010
regulation of immune response	GO:0050776	201	0.010
nuclear transcribed mrna catabolic process nonsense mediated decay	GO:0000184	23	0.010
positive regulation of rac gtpase activity	GO:0032855	31	0.010
head development	GO:0060322	108	0.010

SRPK1 disease predictions

	Disease	DO term ID	Size	Probability	Func Analog Org
	disease of metabolism	DOID:0014667	295	0.011

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