| protein folding | GO:0006457 | 38 | 0.406 | |
| organelle assembly | GO:0070925 | 176 | 0.353 | Yeast |
| post embryonic development | GO:0009791 | 2 | 0.273 | |
| de novo protein folding | GO:0006458 | 2 | 0.235 | |
| negative regulation of cell death | GO:0060548 | 345 | 0.194 | |
| meiosis i | GO:0007127 | 4 | 0.166 | |
| cellular protein complex assembly | GO:0043623 | 188 | 0.157 | Yeast |
| regulation of cell cycle process | GO:0010564 | 266 | 0.118 | |
| negative regulation of protein metabolic process | GO:0051248 | 391 | 0.104 | |
| multicellular organismal aging | GO:0010259 | 3 | 0.101 | |
| mapk cascade | GO:0000165 | 288 | 0.087 | |
| cellular macromolecule catabolic process | GO:0044265 | 380 | 0.087 | |
| negative regulation of phosphate metabolic process | GO:0045936 | 267 | 0.081 | |
| covalent chromatin modification | GO:0016569 | 254 | 0.079 | |
| regulation of intrinsic apoptotic signaling pathway | GO:2001242 | 72 | 0.076 | |
| myosin filament assembly | GO:0031034 | 2 | 0.074 | |
| regulation of mapk cascade | GO:0043408 | 262 | 0.068 | |
| rho protein signal transduction | GO:0007266 | 26 | 0.067 | |
| negative regulation of catalytic activity | GO:0043086 | 335 | 0.065 | |
| regulation of growth | GO:0040008 | 165 | 0.060 | |
| neural crest cell development | GO:0014032 | 3 | 0.056 | |
| regulation of cytoskeleton organization | GO:0051493 | 177 | 0.055 | |
| determination of adult lifespan | GO:0008340 | 2 | 0.054 | |
| microtubule based process | GO:0007017 | 210 | 0.053 | |
| regulation of mitotic cell cycle | GO:0007346 | 189 | 0.050 | |
| circulatory system development | GO:0072359 | 262 | 0.049 | |
| negative regulation of cellular protein metabolic process | GO:0032269 | 353 | 0.049 | |
| heart development | GO:0007507 | 95 | 0.049 | |
| reproductive structure development | GO:0048608 | 55 | 0.048 | |
| negative regulation of protein processing | GO:0010955 | 142 | 0.047 | |
| chaperone mediated protein folding | GO:0061077 | 13 | 0.043 | |
| regulation of protein serine threonine kinase activity | GO:0071900 | 179 | 0.042 | |
| regulation of map kinase activity | GO:0043405 | 108 | 0.041 | |
| striated muscle myosin thick filament assembly | GO:0071688 | 2 | 0.041 | |
| response to nitrogen compound | GO:1901698 | 184 | 0.041 | |
| secretion by cell | GO:0032940 | 226 | 0.040 | |
| negative regulation of proteolysis | GO:0045861 | 132 | 0.040 | |
| regulation of meiotic cell cycle | GO:0051445 | 4 | 0.038 | |
| reproductive system development | GO:0061458 | 56 | 0.038 | |
| gonad development | GO:0008406 | 34 | 0.038 | |
| establishment of protein localization to membrane | GO:0090150 | 121 | 0.038 | |
| calcium ion transport | GO:0006816 | 147 | 0.037 | |
| microtubule cytoskeleton organization | GO:0000226 | 176 | 0.036 | |
| actin cytoskeleton organization | GO:0030036 | 207 | 0.036 | |
| skeletal myofibril assembly | GO:0014866 | 3 | 0.035 | |
| protein peptidyl prolyl isomerization | GO:0000413 | 8 | 0.035 | |
| regulation of cellular amino acid metabolic process | GO:0006521 | 6 | 0.035 | |
| negative regulation of cellular component organization | GO:0051129 | 235 | 0.034 | |
| establishment of protein localization to mitochondrion | GO:0072655 | 22 | 0.034 | |
| negative regulation of protein phosphorylation | GO:0001933 | 140 | 0.034 | |
| regulation of protein kinase activity | GO:0045859 | 289 | 0.033 | |
| regulation of cellular response to stress | GO:0080135 | 244 | 0.033 | |
| posttranscriptional regulation of gene expression | GO:0010608 | 213 | 0.033 | |
| regulation of cell cycle | GO:0051726 | 393 | 0.033 | |
| peptidyl proline modification | GO:0018208 | 15 | 0.033 | |
| purine ribonucleotide catabolic process | GO:0009154 | 404 | 0.033 | |
| cardiocyte differentiation | GO:0035051 | 23 | 0.032 | |
| immune response | GO:0006955 | 307 | 0.032 | |
| response to growth hormone | GO:0060416 | 11 | 0.032 | |
| cellular component morphogenesis | GO:0032989 | 314 | 0.031 | |
| negative regulation of phosphorylation | GO:0042326 | 174 | 0.030 | |
| modification dependent protein catabolic process | GO:0019941 | 209 | 0.030 | |
| positive regulation of cellular catabolic process | GO:0031331 | 284 | 0.029 | |
| ras protein signal transduction | GO:0007265 | 73 | 0.029 | |
| cardiovascular system development | GO:0072358 | 262 | 0.029 | |
| protein catabolic process | GO:0030163 | 325 | 0.029 | |
| small gtpase mediated signal transduction | GO:0007264 | 78 | 0.029 | |
| regulation of proteasomal protein catabolic process | GO:0061136 | 87 | 0.029 | |
| striated muscle cell differentiation | GO:0051146 | 43 | 0.028 | |
| female gamete generation | GO:0007292 | 2 | 0.028 | |
| regulation of stress activated mapk cascade | GO:0032872 | 84 | 0.028 | |
| transmembrane transport | GO:0055085 | 399 | 0.027 | |
| sex differentiation | GO:0007548 | 45 | 0.026 | |
| single organism membrane organization | GO:0044802 | 268 | 0.026 | |
| modification dependent macromolecule catabolic process | GO:0043632 | 212 | 0.026 | |
| actin filament based process | GO:0030029 | 224 | 0.026 | |
| cellular response to calcium ion | GO:0071277 | 19 | 0.026 | |
| regulation of apoptotic signaling pathway | GO:2001233 | 175 | 0.025 | |
| system process | GO:0003008 | 349 | 0.025 | |
| divalent inorganic cation transport | GO:0072511 | 158 | 0.025 | |
| response to organonitrogen compound | GO:0010243 | 156 | 0.024 | |
| protein localization to membrane | GO:0072657 | 160 | 0.024 | |
| ubiquitin dependent protein catabolic process | GO:0006511 | 206 | 0.024 | |
| endocytosis | GO:0006897 | 159 | 0.024 | |
| regulation of cellular component biogenesis | GO:0044087 | 281 | 0.024 | |
| mitotic cell cycle | GO:0000278 | 326 | 0.024 | |
| mitochondrial transport | GO:0006839 | 60 | 0.023 | |
| response to external biotic stimulus | GO:0043207 | 261 | 0.023 | |
| divalent metal ion transport | GO:0070838 | 152 | 0.023 | |
| blood vessel development | GO:0001568 | 172 | 0.023 | |
| striated muscle tissue development | GO:0014706 | 59 | 0.023 | |
| negative regulation of hydrolase activity | GO:0051346 | 182 | 0.022 | |
| nuclear division | GO:0000280 | 128 | 0.022 | |
| regulation of microtubule cytoskeleton organization | GO:0070507 | 61 | 0.022 | |
| anatomical structure formation involved in morphogenesis | GO:0048646 | 284 | 0.022 | |
| nerve development | GO:0021675 | 4 | 0.021 | |
| proteasomal protein catabolic process | GO:0010498 | 176 | 0.021 | |
| negative regulation of protein kinase activity | GO:0006469 | 98 | 0.021 | |
| developmental process involved in reproduction | GO:0003006 | 66 | 0.021 | |
| regulation of protein catabolic process | GO:0042176 | 155 | 0.021 | |
| vasculature development | GO:0001944 | 181 | 0.021 | |
| proteolysis involved in cellular protein catabolic process | GO:0051603 | 244 | 0.020 | |
| apoptotic signaling pathway | GO:0097190 | 268 | 0.020 | |
| negative regulation of protein serine threonine kinase activity | GO:0071901 | 57 | 0.020 | |
| chaperone mediated protein complex assembly | GO:0051131 | 9 | 0.020 | |
| negative regulation of phosphorus metabolic process | GO:0010563 | 267 | 0.020 | |
| dephosphorylation | GO:0016311 | 209 | 0.020 | |
| positive regulation of cell proliferation | GO:0008284 | 301 | 0.020 | |
| cytoplasmic transport | GO:0016482 | 379 | 0.020 | |
| signal transduction by phosphorylation | GO:0023014 | 297 | 0.020 | |
| negative regulation of cellular amine metabolic process | GO:0033239 | 3 | 0.020 | |
| autophagy | GO:0006914 | 88 | 0.020 | |
| positive regulation of dna replication | GO:0045740 | 35 | 0.019 | |
| regulation of cellular ketone metabolic process | GO:0010565 | 50 | 0.019 | |
| receptor mediated endocytosis | GO:0006898 | 84 | 0.019 | |
| cell cycle phase transition | GO:0044770 | 173 | 0.019 | |
| de novo posttranslational protein folding | GO:0051084 | 2 | 0.019 | |
| purine nucleoside catabolic process | GO:0006152 | 398 | 0.019 | |
| myosin filament organization | GO:0031033 | 2 | 0.019 | |
| secretion | GO:0046903 | 254 | 0.019 | |
| neuromuscular junction development | GO:0007528 | 3 | 0.019 | |
| cellular response to metal ion | GO:0071248 | 43 | 0.019 | |
| purine nucleotide catabolic process | GO:0006195 | 405 | 0.018 | |
| macromolecule methylation | GO:0043414 | 97 | 0.018 | |
| negative regulation of protein modification process | GO:0031400 | 200 | 0.018 | |
| cell cycle checkpoint | GO:0000075 | 117 | 0.018 | |
| negative regulation of mitotic cell cycle phase transition | GO:1901991 | 85 | 0.018 | |
| vesicle mediated transport | GO:0016192 | 371 | 0.018 | |
| stress activated protein kinase signaling cascade | GO:0031098 | 94 | 0.018 | |
| negative regulation of mitotic cell cycle | GO:0045930 | 102 | 0.018 | |
| protein localization to mitochondrion | GO:0070585 | 25 | 0.018 | |
| response to abiotic stimulus | GO:0009628 | 336 | 0.018 | |
| muscle cell development | GO:0055001 | 29 | 0.017 | |
| oxidation reduction process | GO:0055114 | 396 | 0.017 | |
| negative regulation of programmed cell death | GO:0043069 | 321 | 0.017 | |
| response to peptide | GO:1901652 | 65 | 0.017 | |
| reproductive process | GO:0022414 | 106 | 0.017 | |
| growth | GO:0040007 | 202 | 0.017 | |
| chaperone cofactor dependent protein refolding | GO:0070389 | 4 | 0.017 | |
| cellular amino acid metabolic process | GO:0006520 | 116 | 0.017 | |
| sensory perception of pain | GO:0019233 | 4 | 0.017 | |
| negative regulation of jnk cascade | GO:0046329 | 16 | 0.017 | |
| purine nucleoside triphosphate catabolic process | GO:0009146 | 392 | 0.017 | |
| regulation of dna replication | GO:0006275 | 68 | 0.017 | |
| protein maturation | GO:0051604 | 233 | 0.016 | |
| g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger | GO:0007187 | 43 | 0.016 | |
| ribonucleoprotein complex biogenesis | GO:0022613 | 116 | 0.016 | |
| intracellular steroid hormone receptor signaling pathway | GO:0030518 | 61 | 0.016 | |
| cellular macromolecular complex assembly | GO:0034622 | 324 | 0.016 | Yeast |
| nucleotide catabolic process | GO:0009166 | 408 | 0.016 | |
| regulation of dephosphorylation | GO:0035303 | 96 | 0.016 | |
| positive regulation of meiotic cell cycle | GO:0051446 | 2 | 0.016 | |
| response to calcium ion | GO:0051592 | 46 | 0.016 | |
| g protein coupled receptor signaling pathway | GO:0007186 | 207 | 0.015 | |
| cellular component assembly involved in morphogenesis | GO:0010927 | 73 | 0.015 | |
| nuclear transport | GO:0051169 | 179 | 0.015 | |
| response to metal ion | GO:0010038 | 84 | 0.015 | |
| muscle cell differentiation | GO:0042692 | 63 | 0.015 | |
| cellular ketone metabolic process | GO:0042180 | 80 | 0.015 | |
| protein transmembrane transport | GO:0071806 | 25 | 0.015 | |
| hemoglobin metabolic process | GO:0020027 | 3 | 0.015 | |
| mitotic cell cycle process | GO:1903047 | 286 | 0.015 | |
| ncrna processing | GO:0034470 | 83 | 0.014 | |
| positive regulation of apoptotic process | GO:0043065 | 246 | 0.014 | |
| neural crest cell migration | GO:0001755 | 2 | 0.014 | |
| cellular protein catabolic process | GO:0044257 | 261 | 0.014 | |
| regulation of body fluid levels | GO:0050878 | 99 | 0.014 | |
| cardiac muscle tissue development | GO:0048738 | 39 | 0.014 | |
| negative regulation of cell cycle | GO:0045786 | 193 | 0.014 | |
| ion homeostasis | GO:0050801 | 230 | 0.014 | |
| chromosome separation | GO:0051304 | 23 | 0.014 | |
| regulation of protein secretion | GO:0050708 | 86 | 0.014 | |
| proteasome mediated ubiquitin dependent protein catabolic process | GO:0043161 | 156 | 0.014 | |
| positive regulation of developmental process | GO:0051094 | 314 | 0.014 | |
| negative regulation of kinase activity | GO:0033673 | 106 | 0.014 | |
| defense response | GO:0006952 | 315 | 0.014 | |
| positive regulation of cell cycle | GO:0045787 | 140 | 0.013 | |
| negative regulation of organelle organization | GO:0010639 | 126 | 0.013 | |
| mitotic cell cycle phase transition | GO:0044772 | 162 | 0.013 | |
| regulation of proteasomal ubiquitin dependent protein catabolic process | GO:0032434 | 71 | 0.013 | |
| reproduction | GO:0000003 | 63 | 0.013 | Worm |
| ribonucleotide catabolic process | GO:0009261 | 405 | 0.013 | |
| regulation of cell growth | GO:0001558 | 135 | 0.013 | |
| regulation of mitosis | GO:0007088 | 63 | 0.013 | |
| protein ubiquitination | GO:0016567 | 314 | 0.013 | |
| protein secretion | GO:0009306 | 98 | 0.013 | |
| positive regulation of intrinsic apoptotic signaling pathway | GO:2001244 | 28 | 0.013 | |
| dna replication | GO:0006260 | 116 | 0.013 | |
| embryo development | GO:0009790 | 123 | 0.013 | Worm |
| muscle tissue development | GO:0060537 | 62 | 0.013 | |
| development of primary sexual characteristics | GO:0045137 | 35 | 0.013 | |
| cranial nerve development | GO:0021545 | 4 | 0.013 | |
| regulation of ion transport | GO:0043269 | 189 | 0.013 | |
| negative regulation of protein catabolic process | GO:0042177 | 59 | 0.012 | |
| cardiac muscle cell differentiation | GO:0055007 | 15 | 0.012 | |
| actomyosin structure organization | GO:0031032 | 59 | 0.012 | |
| purine containing compound catabolic process | GO:0072523 | 411 | 0.012 | |
| protein alkylation | GO:0008213 | 74 | 0.012 | |
| regulation of metal ion transport | GO:0010959 | 120 | 0.012 | |
| protein targeting | GO:0006605 | 187 | 0.012 | |
| ribonucleoside triphosphate catabolic process | GO:0009203 | 391 | 0.012 | |
| protein methylation | GO:0006479 | 74 | 0.012 | |
| cell growth | GO:0016049 | 160 | 0.012 | |
| aging | GO:0007568 | 66 | 0.012 | |
| organ formation | GO:0048645 | 3 | 0.012 | |
| regulation of calcium ion transport | GO:0051924 | 79 | 0.012 | |
| negative regulation of stress activated mapk cascade | GO:0032873 | 19 | 0.012 | |
| positive regulation of apoptotic signaling pathway | GO:2001235 | 70 | 0.012 | |
| chromatin modification | GO:0016568 | 298 | 0.012 | |
| negative regulation of cellular amino acid metabolic process | GO:0045763 | 2 | 0.012 | |
| guanosine containing compound catabolic process | GO:1901069 | 239 | 0.012 | |
| ribonucleoprotein complex subunit organization | GO:0071826 | 81 | 0.012 | |
| positive regulation of angiogenesis | GO:0045766 | 51 | 0.012 | |
| oogenesis | GO:0048477 | 2 | 0.012 | |
| response to radiation | GO:0009314 | 151 | 0.012 | |
| protein modification by small protein conjugation | GO:0032446 | 342 | 0.011 | |
| regulation of vasculature development | GO:1901342 | 97 | 0.011 | |
| metal ion transport | GO:0030001 | 272 | 0.011 | |
| mitochondrion organization | GO:0007005 | 156 | 0.011 | |
| angiogenesis | GO:0001525 | 147 | 0.011 | |
| regulation of autophagy | GO:0010506 | 52 | 0.011 | |
| peptidyl threonine modification | GO:0018210 | 45 | 0.011 | |
| regulation of system process | GO:0044057 | 101 | 0.011 | |
| regulation of cell cycle phase transition | GO:1901987 | 126 | 0.011 | |
| jnk cascade | GO:0007254 | 80 | 0.011 | |
| histone modification | GO:0016570 | 251 | 0.011 | |
| neurological system process | GO:0050877 | 163 | 0.011 | |
| mitochondrial membrane organization | GO:0007006 | 40 | 0.011 | |
| erk1 and erk2 cascade | GO:0070371 | 104 | 0.011 | |
| negative regulation of transferase activity | GO:0051348 | 124 | 0.011 | |
| regulation of anatomical structure morphogenesis | GO:0022603 | 286 | 0.011 | |
| negative regulation of phosphatase activity | GO:0010923 | 61 | 0.011 | |
| endosomal transport | GO:0016197 | 129 | 0.011 | |
| nucleoside triphosphate catabolic process | GO:0009143 | 394 | 0.011 | |
| negative regulation of apoptotic process | GO:0043066 | 316 | 0.011 | |
| endomembrane system organization | GO:0010256 | 196 | 0.011 | |
| regulation of cell division | GO:0051302 | 116 | 0.011 | |
| cell development | GO:0048468 | 328 | 0.011 | |
| positive regulation of protein secretion | GO:0050714 | 60 | 0.011 | |
| meiotic chromosome segregation | GO:0045132 | 4 | 0.011 | |
| amine metabolic process | GO:0009308 | 44 | 0.011 | |
| regulation of protein transport | GO:0051223 | 213 | 0.011 | |
| establishment of protein localization to organelle | GO:0072594 | 172 | 0.011 | |
| membrane organization | GO:0061024 | 292 | 0.011 | |
| regulation of establishment of protein localization | GO:0070201 | 242 | 0.011 | |
| peripheral nervous system development | GO:0007422 | 2 | 0.011 | |
| positive regulation of catabolic process | GO:0009896 | 310 | 0.011 | |
| anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process | GO:0031145 | 25 | 0.011 | |
| regulation of small gtpase mediated signal transduction | GO:0051056 | 156 | 0.011 | |
| positive regulation of cell death | GO:0010942 | 263 | 0.010 | |
| muscle structure development | GO:0061061 | 98 | 0.010 | |
| segmentation | GO:0035282 | 4 | 0.010 | |
| regulation of reactive oxygen species metabolic process | GO:2000377 | 41 | 0.010 | |
| behavior | GO:0007610 | 112 | 0.010 | |
| positive regulation of hydrolase activity | GO:0051345 | 331 | 0.010 | |
| i kappab kinase nf kappab signaling | GO:0007249 | 166 | 0.010 | |
| lipid metabolic process | GO:0006629 | 381 | 0.010 | |
| regulation of cellular protein catabolic process | GO:1903362 | 96 | 0.010 | |
