IMP: Integrative Multi-species Prediction

Homo sapiens

0 known processes

TCEB1

transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)

(Aliases: SIII)

MIM: 600788
HGNC: 11617
HPRD: 02875
Ensembl: ENSG00000154582
Entrez: 6921
UniProtKB: Q15369
UniProtKB: A0A024R7Y5

Process Predictions
Disease Predictions

TCEB1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
regulation of proteolysis involved in cellular protein catabolic process	GO:1903050	91	0.986
regulation of proteasomal protein catabolic process	GO:0061136	87	0.975
cellular macromolecule catabolic process	GO:0044265	380	0.973
positive regulation of proteasomal protein catabolic process	GO:1901800	35	0.968
positive regulation of catabolic process	GO:0009896	310	0.963
protein modification by small protein conjugation	GO:0032446	342	0.960
modification dependent protein catabolic process	GO:0019941	209	0.958
cellular protein catabolic process	GO:0044257	261	0.930
protein catabolic process	GO:0030163	325	0.928
proteasomal protein catabolic process	GO:0010498	176	0.918
cellular amine metabolic process	GO:0044106	41	0.911
regulation of cellular amino acid metabolic process	GO:0006521	6	0.899
positive regulation of proteolysis	GO:0045862	142	0.898
regulation of cellular protein catabolic process	GO:1903362	96	0.892
cell development	GO:0048468	328	0.863	Fly
ubiquitin dependent protein catabolic process	GO:0006511	206	0.855
regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032434	71	0.855
post embryonic development	GO:0009791	2	0.847	Worm Fly
proteolysis involved in cellular protein catabolic process	GO:0051603	244	0.828
regulation of cell cycle	GO:0051726	393	0.822	Worm
positive regulation of protein catabolic process	GO:0045732	75	0.820
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	156	0.815
regulation of protein catabolic process	GO:0042176	155	0.767
nervous system development	GO:0007399	293	0.630	Fly
cyclin catabolic process	GO:0008054	6	0.624
positive regulation of cellular protein catabolic process	GO:1903364	37	0.594
positive regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032436	30	0.539
cellular response to oxygen containing compound	GO:1901701	276	0.534
modification dependent macromolecule catabolic process	GO:0043632	212	0.531
amine metabolic process	GO:0009308	44	0.517
regulation of transferase activity	GO:0051338	355	0.513
negative regulation of jak stat cascade	GO:0046426	4	0.501
positive regulation of proteolysis involved in cellular protein catabolic process	GO:1903052	35	0.466
segmentation	GO:0035282	4	0.444	Worm
meiotic chromosome segregation	GO:0045132	4	0.404	Worm
microtubule based movement	GO:0007018	32	0.386	Worm
regulation of cell cycle process	GO:0010564	266	0.385	Worm
female gamete generation	GO:0007292	2	0.381
regulation of cellular amine metabolic process	GO:0033238	11	0.372
positive regulation of cellular catabolic process	GO:0031331	284	0.363
reproductive system development	GO:0061458	56	0.361
regulation of cellular ketone metabolic process	GO:0010565	50	0.357
protein ubiquitination	GO:0016567	314	0.354
regulation of ligase activity	GO:0051340	29	0.338
establishment of nucleus localization	GO:0040023	1	0.334
regulation of kinase activity	GO:0043549	314	0.331
behavior	GO:0007610	112	0.327
cellular response to organonitrogen compound	GO:0071417	124	0.314
neurogenesis	GO:0022008	169	0.310	Fly
mitotic sister chromatid segregation	GO:0000070	53	0.306
regulation of proteolysis	GO:0030162	293	0.295
regulation of ubiquitin protein transferase activity	GO:0051438	28	0.295
positive regulation of hormone biosynthetic process	GO:0046886	4	0.291
sister chromatid segregation	GO:0000819	54	0.291	Worm
negative regulation of cellular amine metabolic process	GO:0033239	3	0.277
negative regulation of transcription from rna polymerase ii promoter in response to hypoxia	GO:0061428	4	0.263
mitotic cell cycle process	GO:1903047	286	0.251
multicellular organismal aging	GO:0010259	3	0.249
erbb signaling pathway	GO:0038127	44	0.245
negative regulation of catalytic activity	GO:0043086	335	0.235
epithelial cell migration	GO:0010631	119	0.230
regulation of mitotic cell cycle	GO:0007346	189	0.229	Worm
embryo development	GO:0009790	123	0.225	Worm
regulation of meiotic cell cycle	GO:0051445	4	0.209	Worm
cellular response to hormone stimulus	GO:0032870	125	0.209
protein targeting	GO:0006605	187	0.199
negative regulation of protein kinase activity	GO:0006469	98	0.187
positive regulation of meiotic cell cycle	GO:0051446	2	0.185	Worm
regulation of cell division	GO:0051302	116	0.185	Worm
ameboidal type cell migration	GO:0001667	135	0.182
nuclear migration	GO:0007097	1	0.179
single organism cellular localization	GO:1902580	332	0.179
single organism reproductive process	GO:0044702	98	0.175
regulation of protein kinase activity	GO:0045859	289	0.164
developmental process involved in reproduction	GO:0003006	66	0.164
cell cycle checkpoint	GO:0000075	117	0.163
cellular protein complex assembly	GO:0043623	188	0.162
negative regulation of protein metabolic process	GO:0051248	391	0.158
organ formation	GO:0048645	3	0.157
regulation of cellular component biogenesis	GO:0044087	281	0.156
cell morphogenesis	GO:0000902	296	0.150	Fly
negative regulation of kinase activity	GO:0033673	106	0.146
response to lipid	GO:0033993	206	0.145
determination of adult lifespan	GO:0008340	2	0.142
cellular ketone metabolic process	GO:0042180	80	0.134
cellular amino acid metabolic process	GO:0006520	116	0.134
negative regulation of mitotic cell cycle	GO:0045930	102	0.133
regulation of apoptotic signaling pathway	GO:2001233	175	0.132
response to hormone	GO:0009725	175	0.129
cellular response to peptide hormone stimulus	GO:0071375	56	0.124
response to steroid hormone	GO:0048545	80	0.124
nucleus localization	GO:0051647	1	0.121
embryo development ending in birth or egg hatching	GO:0009792	34	0.119	Worm
cellular macromolecular complex assembly	GO:0034622	324	0.118
anterior posterior axis specification embryo	GO:0008595	2	0.117	Worm
regulation of sister chromatid segregation	GO:0033045	27	0.116	Worm
anterior posterior axis specification	GO:0009948	2	0.112	Worm
organelle localization	GO:0051640	84	0.110	Worm
single fertilization	GO:0007338	11	0.106
cellular response to peptide	GO:1901653	59	0.106
growth	GO:0040007	202	0.106
oogenesis	GO:0048477	2	0.104
response to peptide	GO:1901652	65	0.103
regulation of g2 m transition of mitotic cell cycle	GO:0010389	20	0.101
response to estradiol	GO:0032355	23	0.100
oocyte differentiation	GO:0009994	2	0.098
cellular response to nitrogen compound	GO:1901699	144	0.098
positive regulation of cellular component biogenesis	GO:0044089	158	0.093
microtubule based process	GO:0007017	210	0.090	Worm
neuron differentiation	GO:0030182	138	0.087	Fly
regulation of sequence specific dna binding transcription factor activity	GO:0051090	211	0.085
reproductive process	GO:0022414	106	0.084
negative regulation of apoptotic process	GO:0043066	316	0.083
tissue migration	GO:0090130	119	0.081
establishment of protein localization to organelle	GO:0072594	172	0.080
cullin deneddylation	GO:0010388	9	0.080
cytoplasmic transport	GO:0016482	379	0.077
regulation of epidermal growth factor activated receptor activity	GO:0007176	14	0.075
gonad development	GO:0008406	34	0.072
negative regulation of receptor activity	GO:2000272	15	0.072
growth hormone receptor signaling pathway	GO:0060396	10	0.070
regulation of protein ubiquitination	GO:0031396	95	0.069
stem cell differentiation	GO:0048863	93	0.069
response to organic cyclic compound	GO:0014070	204	0.068
reproductive structure development	GO:0048608	55	0.066
protein localization to organelle	GO:0033365	280	0.066
mitotic sister chromatid separation	GO:0051306	18	0.065
regulation of cellular response to stress	GO:0080135	244	0.064
negative regulation of programmed cell death	GO:0043069	321	0.064
regulation of mitotic sister chromatid segregation	GO:0033047	27	0.064	Worm
actin filament based process	GO:0030029	224	0.063
negative regulation of mitotic cell cycle phase transition	GO:1901991	85	0.063
negative regulation of cellular amino acid metabolic process	GO:0045763	2	0.062
positive regulation of developmental process	GO:0051094	314	0.061
positive regulation of kinase activity	GO:0033674	204	0.060
protein import into mitochondrial matrix	GO:0030150	1	0.060
multicellular organism reproduction	GO:0032504	42	0.059
protein targeting to nucleus	GO:0044744	104	0.059
establishment of organelle localization	GO:0051656	59	0.058	Worm
purine nucleoside triphosphate metabolic process	GO:0009144	412	0.058
neural crest cell development	GO:0014032	3	0.057
regulation of protein stability	GO:0031647	87	0.056
chemical homeostasis	GO:0048878	306	0.056
blastoderm segmentation	GO:0007350	2	0.054	Worm
posttranscriptional regulation of gene expression	GO:0010608	213	0.054
response to abiotic stimulus	GO:0009628	336	0.053
negative regulation of sequence specific dna binding transcription factor activity	GO:0043433	89	0.053
regulation of locomotion	GO:0040012	329	0.052
organelle fission	GO:0048285	149	0.052	Worm
negative regulation of g2 m transition of mitotic cell cycle	GO:0010972	9	0.051
intracellular protein transport	GO:0006886	270	0.051
cell division	GO:0051301	168	0.050
aging	GO:0007568	66	0.050
regulation of nuclear division	GO:0051783	65	0.050	Worm
neuron projection morphogenesis	GO:0048812	50	0.049	Fly
positive regulation of protein modification by small protein conjugation or removal	GO:1903322	61	0.049
neuromuscular junction development	GO:0007528	3	0.048
mitotic cell cycle checkpoint	GO:0007093	68	0.048
protein import into nucleus	GO:0006606	104	0.048
alcohol metabolic process	GO:0006066	114	0.048
cellular component morphogenesis	GO:0032989	314	0.047	Fly
tripartite regional subdivision	GO:0007351	2	0.047	Worm
response to growth hormone	GO:0060416	11	0.047
multicellular organismal reproductive process	GO:0048609	40	0.047
sex differentiation	GO:0007548	45	0.047
protein modification by small protein removal	GO:0070646	92	0.046
cytokine production	GO:0001816	247	0.045
regulation of protein tyrosine kinase activity	GO:0061097	36	0.045
negative regulation of phosphorus metabolic process	GO:0010563	267	0.045
actin cytoskeleton organization	GO:0030036	207	0.043
cell type specific apoptotic process	GO:0097285	125	0.042
meiosis i	GO:0007127	4	0.042
stem cell development	GO:0048864	69	0.041
negative regulation of phosphate metabolic process	GO:0045936	267	0.041
fertilization	GO:0009566	12	0.041
response to alcohol	GO:0097305	64	0.041
response to peptide hormone	GO:0043434	61	0.040
positive regulation of transferase activity	GO:0051347	227	0.040
cytokinesis	GO:0000910	96	0.039
circulatory system development	GO:0072359	262	0.038
single organism nuclear import	GO:1902593	104	0.038
neuron development	GO:0048666	113	0.038	Fly
peptidyl tyrosine modification	GO:0018212	170	0.037
stress activated protein kinase signaling cascade	GO:0031098	94	0.037
negative regulation of protein phosphorylation	GO:0001933	140	0.037
regulation of peptidyl tyrosine phosphorylation	GO:0050730	108	0.037
response to oxygen containing compound	GO:1901700	369	0.036
organic hydroxy compound metabolic process	GO:1901615	147	0.036
response to organonitrogen compound	GO:0010243	156	0.035
response to nitrogen compound	GO:1901698	184	0.035
epithelium migration	GO:0090132	119	0.035
organ morphogenesis	GO:0009887	147	0.035	Fly
dna integrity checkpoint	GO:0031570	71	0.035
positive regulation of cytokine production	GO:0001819	167	0.035
mitotic dna integrity checkpoint	GO:0044774	30	0.034
negative regulation of intracellular signal transduction	GO:1902532	183	0.034
positive regulation of programmed cell death	GO:0043068	249	0.034
guanosine containing compound metabolic process	GO:1901068	244	0.034
regulation of mitotic cell cycle phase transition	GO:1901990	118	0.033
purine ribonucleoside metabolic process	GO:0046128	437	0.033
positive regulation of protein kinase activity	GO:0045860	190	0.033
enzyme linked receptor protein signaling pathway	GO:0007167	303	0.033
regulation of metaphase anaphase transition of cell cycle	GO:1902099	26	0.032	Worm
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.031
secretion	GO:0046903	254	0.031
glial cell migration	GO:0008347	4	0.031
protein maturation	GO:0051604	233	0.031
negative regulation of cellular protein metabolic process	GO:0032269	353	0.030
positive regulation of phosphorylation	GO:0042327	394	0.030
cell cell signaling involved in cell fate commitment	GO:0045168	5	0.030
reproduction	GO:0000003	63	0.030	Worm
chromosome segregation	GO:0007059	114	0.030	Worm
stress activated mapk cascade	GO:0051403	93	0.029
exosomal secretion	GO:1990182	15	0.029
regulation of jak stat cascade	GO:0046425	44	0.029
development of primary sexual characteristics	GO:0045137	35	0.029
epidermal growth factor receptor signaling pathway	GO:0007173	39	0.028
positive regulation of protein phosphorylation	GO:0001934	313	0.028
negative regulation of protein modification process	GO:0031400	200	0.028
regulation of cell development	GO:0060284	161	0.028
positive regulation of apoptotic process	GO:0043065	246	0.028
golgi vesicle transport	GO:0048193	80	0.027
cell projection morphogenesis	GO:0048858	129	0.027	Fly
cellular response to endogenous stimulus	GO:0071495	336	0.027
mitotic nuclear division	GO:0007067	119	0.027
response to estrogen	GO:0043627	47	0.026
cell fate determination	GO:0001709	3	0.026
lipid biosynthetic process	GO:0008610	177	0.026
blood vessel morphogenesis	GO:0048514	162	0.026
negative regulation of phosphorylation	GO:0042326	174	0.025
locomotory behavior	GO:0007626	1	0.025
regulation of receptor activity	GO:0010469	47	0.025
chemotaxis	GO:0006935	157	0.024
negative regulation of peptidyl tyrosine phosphorylation	GO:0050732	20	0.024
vasculature development	GO:0001944	181	0.024
taxis	GO:0042330	157	0.024
response to bacterium	GO:0009617	144	0.024
protein localization to nucleus	GO:0034504	136	0.024
organelle assembly	GO:0070925	176	0.024
memory	GO:0007613	3	0.024
regulation of meiosis	GO:0040020	3	0.024
generation of neurons	GO:0048699	152	0.023	Fly
response to inorganic substance	GO:0010035	127	0.023
negative regulation of epidermal growth factor receptor signaling pathway	GO:0042059	11	0.023
cell death in response to oxidative stress	GO:0036473	29	0.023
cellular response to hypoxia	GO:0071456	51	0.023
hindbrain development	GO:0030902	3	0.023
negative regulation of developmental process	GO:0051093	247	0.023
regulation of mitosis	GO:0007088	63	0.022	Worm
regionalization	GO:0003002	29	0.022	Worm Fly
regulation of nucleotide metabolic process	GO:0006140	269	0.022
positive regulation of sequence specific dna binding transcription factor activity	GO:0051091	131	0.021
activation of janus kinase activity	GO:0042976	7	0.021
negative regulation of cellular protein catabolic process	GO:1903363	38	0.021
regulation of map kinase activity	GO:0043405	108	0.021
negative regulation of cell cycle	GO:0045786	193	0.020
regulation of cell morphogenesis	GO:0022604	153	0.020
ribonucleoprotein complex assembly	GO:0022618	78	0.020
regulation of cytokine secretion	GO:0050707	57	0.020
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	181	0.020
mitotic cell cycle phase transition	GO:0044772	162	0.019
negative regulation of transferase activity	GO:0051348	124	0.019
regulation of protein transport	GO:0051223	213	0.019
neural crest cell migration	GO:0001755	2	0.019
long term memory	GO:0007616	2	0.019
cellular response to growth hormone stimulus	GO:0071378	10	0.019
regulation of erbb signaling pathway	GO:1901184	27	0.019
mitotic cell cycle	GO:0000278	326	0.018
regulation of cellular component movement	GO:0051270	334	0.018
blood vessel development	GO:0001568	172	0.018
organonitrogen compound biosynthetic process	GO:1901566	200	0.018
cell projection organization	GO:0030030	252	0.018	Fly
cellular homeostasis	GO:0019725	196	0.018
activation of protein kinase activity	GO:0032147	90	0.018
negative regulation of cell death	GO:0060548	345	0.017
transmembrane transport	GO:0055085	399	0.017
regulation of activation of jak2 kinase activity	GO:0010534	5	0.017
regulation of mitotic spindle checkpoint	GO:1903504	8	0.017
chromosome separation	GO:0051304	23	0.017
autophagy	GO:0006914	88	0.017
regulation of protein modification by small protein conjugation or removal	GO:1903320	107	0.017
nucleocytoplasmic transport	GO:0006913	176	0.017
nuclear import	GO:0051170	106	0.017
mesenchymal cell development	GO:0014031	50	0.017
hemopoiesis	GO:0030097	180	0.016
negative regulation of protein tyrosine kinase activity	GO:0061099	13	0.016
regulation of anatomical structure size	GO:0090066	101	0.016
positive regulation of peptidase activity	GO:0010952	88	0.016
negative regulation of protein catabolic process	GO:0042177	59	0.016
establishment of chromosome localization	GO:0051303	20	0.016	Worm
regulation of protein localization	GO:0032880	296	0.016
glycerophospholipid metabolic process	GO:0006650	84	0.016
nls bearing protein import into nucleus	GO:0006607	2	0.016
cytokine secretion	GO:0050663	64	0.015
protein secretion	GO:0009306	98	0.015
positive regulation of cell differentiation	GO:0045597	211	0.015
regulation of secretion by cell	GO:1903530	177	0.015
system process	GO:0003008	349	0.015
regulation of protein serine threonine kinase activity	GO:0071900	179	0.015
neuron projection development	GO:0031175	106	0.015	Fly
sexual reproduction	GO:0019953	37	0.015
thymocyte apoptotic process	GO:0070242	2	0.015
negative regulation of proteolysis	GO:0045861	132	0.015
inflammatory response	GO:0006954	79	0.015
negative regulation of epidermal growth factor activated receptor activity	GO:0007175	6	0.015
stem cell division	GO:0017145	2	0.015
nuclear transport	GO:0051169	179	0.015
protein import	GO:0017038	130	0.014
cellular response to dna damage stimulus	GO:0006974	379	0.014
response to external biotic stimulus	GO:0043207	261	0.014
protein polyubiquitination	GO:0000209	110	0.014
secretion by cell	GO:0032940	226	0.014
cell cycle phase transition	GO:0044770	173	0.014	Worm
multi organism reproductive process	GO:0044703	54	0.014
actin filament organization	GO:0007015	128	0.014
striated muscle tissue development	GO:0014706	59	0.014
neurotransmitter gated ion channel clustering	GO:0072578	1	0.013
anatomical structure formation involved in morphogenesis	GO:0048646	284	0.013
small molecule biosynthetic process	GO:0044283	157	0.013
nucleotide catabolic process	GO:0009166	408	0.013
jnk cascade	GO:0007254	80	0.013
protein polymerization	GO:0051258	71	0.013
guanosine containing compound catabolic process	GO:1901069	239	0.013
response to other organism	GO:0051707	261	0.013
multicellular organismal response to stress	GO:0033555	1	0.013
mitochondrion organization	GO:0007005	156	0.013
negative regulation of cell cycle phase transition	GO:1901988	89	0.013
mitotic g2 m transition checkpoint	GO:0044818	9	0.013
regulation of mitotic sister chromatid separation	GO:0010965	27	0.012	Worm
single organism behavior	GO:0044708	28	0.012
positive regulation of nervous system development	GO:0051962	54	0.012
regulation of neuron death	GO:1901214	56	0.012
epithelial cell development	GO:0002064	34	0.012
negative regulation of thymocyte apoptotic process	GO:0070244	1	0.012
hemoglobin metabolic process	GO:0020027	3	0.012
phospholipid biosynthetic process	GO:0008654	44	0.012
regulation of anatomical structure morphogenesis	GO:0022603	286	0.012
g2 m transition of mitotic cell cycle	GO:0000086	41	0.012
negative regulation of cellular catabolic process	GO:0031330	83	0.012
response to virus	GO:0009615	126	0.011
regulation of response to external stimulus	GO:0032101	222	0.011
cell morphogenesis involved in neuron differentiation	GO:0048667	44	0.011	Fly
epithelium development	GO:0060429	227	0.011
organophosphate catabolic process	GO:0046434	430	0.011
intrinsic apoptotic signaling pathway	GO:0097193	127	0.011
spindle organization	GO:0007051	53	0.011
regulation of cytokine production	GO:0001817	232	0.011
organophosphate biosynthetic process	GO:0090407	163	0.011
nitrogen compound transport	GO:0071705	191	0.011
regulation of chromosome segregation	GO:0051983	44	0.011	Worm
response to activity	GO:0014823	0	0.011
gtp catabolic process	GO:0006184	237	0.011
developmental growth	GO:0048589	48	0.011
positive regulation of nucleoside metabolic process	GO:0045979	186	0.011
meiotic nuclear division	GO:0007126	10	0.011	Worm
signal transduction by phosphorylation	GO:0023014	297	0.011
cell chemotaxis	GO:0060326	112	0.011
negative regulation of immune response	GO:0050777	40	0.011
glycosyl compound catabolic process	GO:1901658	413	0.010
response to oxygen levels	GO:0070482	100	0.010
regulation of actin cytoskeleton organization	GO:0032956	116	0.010
regulation of actin filament based process	GO:0032970	141	0.010
positive regulation of cell development	GO:0010720	92	0.010
regulation of transcription from rna polymerase ii promoter in response to hypoxia	GO:0061418	7	0.010

TCEB1 disease predictions

Disease	DO term ID	Size	Probability
cell type benign neoplasm	DOID:0060084	10	0.139
phaeochromocytoma	DOID:0050771	8	0.139
benign neoplasm	DOID:0060072	18	0.139
disease of cellular proliferation	DOID:14566	174	0.139
inherited metabolic disorder	DOID:655	242	0.092
disease of metabolism	DOID:0014667	295	0.092
cancer	DOID:162	167	0.063
organ system cancer	DOID:0050686	164	0.047
urinary system cancer	DOID:3996	15	0.047
renal carcinoma	DOID:4451	8	0.047
kidney cancer	DOID:263	11	0.047
developmental disorder of mental health	DOID:0060037	29	0.028
disease of mental health	DOID:150	70	0.028
renal cell carcinoma	DOID:4450	8	0.023

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