IMP: Integrative Multi-species Prediction

Homo sapiens

277 known processes

TSC1

tuberous sclerosis 1

(Aliases: TSC,LAM,MGC86987,KIAA0243)

Ensembl: ENSG00000165699
Entrez: 7248
HGNC: 12362
MIM: 605284
HPRD: 05594
UniProtKB: Q86WV8
UniProtKB: X5D9D2
UniProtKB: Q92574
UniProtKB: Q32NF0

Process Predictions
Disease Predictions

TSC1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
negative regulation of phosphatidylinositol 3 kinase signaling	GO:0014067	4	0.977
nucleoside triphosphate catabolic process	GO:0009143	394	0.902
regulation of gtp catabolic process	GO:0033124	180	0.890
glycosyl compound catabolic process	GO:1901658	413	0.784
gtp metabolic process	GO:0046039	239	0.768
purine nucleotide catabolic process	GO:0006195	405	0.641
ras protein signal transduction	GO:0007265	73	0.631
regulation of ras gtpase activity	GO:0032318	128	0.616
regulation of purine nucleotide metabolic process	GO:1900542	264	0.563
purine ribonucleoside catabolic process	GO:0046130	398	0.562
ribonucleoside catabolic process	GO:0042454	406	0.547
cellular response to dna damage stimulus	GO:0006974	379	0.541
guanosine containing compound catabolic process	GO:1901069	239	0.536
positive regulation of gtpase activity	GO:0043547	166	0.536
cellular response to oxygen containing compound	GO:1901701	276	0.534	Fly
ribonucleotide catabolic process	GO:0009261	405	0.533
positive regulation of purine nucleotide metabolic process	GO:1900544	227	0.516
purine nucleoside catabolic process	GO:0006152	398	0.506
nucleoside phosphate catabolic process	GO:1901292	412	0.502
nucleotide catabolic process	GO:0009166	408	0.500
positive regulation of nucleotide catabolic process	GO:0030813	185	0.490
response to oxygen containing compound	GO:1901700	369	0.490
purine ribonucleoside triphosphate metabolic process	GO:0009205	411	0.477
purine ribonucleoside triphosphate catabolic process	GO:0009207	391	0.442
neuromuscular junction development	GO:0007528	3	0.438
purine ribonucleotide catabolic process	GO:0009154	404	0.437
morphogenesis of embryonic epithelium	GO:0016331	4	0.431	Mouse
positive regulation of gtp catabolic process	GO:0033126	166	0.427
purine nucleoside triphosphate catabolic process	GO:0009146	392	0.419
small gtpase mediated signal transduction	GO:0007264	78	0.413
gtp catabolic process	GO:0006184	237	0.410
regulation of nucleoside metabolic process	GO:0009118	209	0.400
guanosine containing compound metabolic process	GO:1901068	244	0.388
regulation of protein localization	GO:0032880	296	0.378
positive regulation of nucleoside metabolic process	GO:0045979	186	0.369
negative regulation of developmental process	GO:0051093	247	0.356	Fly
regulation of gtpase activity	GO:0043087	180	0.351
purine nucleoside triphosphate metabolic process	GO:0009144	412	0.350
positive regulation of ras gtpase activity	GO:0032320	117	0.318
regulation of cellular component biogenesis	GO:0044087	281	0.313
response to hypoxia	GO:0001666	96	0.311	Fly
regulation of nucleotide catabolic process	GO:0030811	205	0.302
positive regulation of purine nucleotide catabolic process	GO:0033123	185	0.299
nucleoside triphosphate metabolic process	GO:0009141	422	0.298
carbohydrate transport	GO:0008643	37	0.297	Mouse
positive regulation of hydrolase activity	GO:0051345	331	0.276
negative regulation of protein metabolic process	GO:0051248	391	0.269
organophosphate catabolic process	GO:0046434	430	0.265
oogenesis	GO:0048477	2	0.262	Fly
positive regulation of catabolic process	GO:0009896	310	0.256
acute phase response	GO:0006953	5	0.252
establishment of protein localization to organelle	GO:0072594	172	0.248
positive regulation of cellular catabolic process	GO:0031331	284	0.243
ribonucleoside triphosphate metabolic process	GO:0009199	412	0.235
protein localization to membrane	GO:0072657	160	0.233
protein localization to organelle	GO:0033365	280	0.229
rab protein signal transduction	GO:0032482	4	0.228
response to nitrogen compound	GO:1901698	184	0.218
purine containing compound catabolic process	GO:0072523	411	0.215
negative regulation of wnt signaling pathway	GO:0030178	69	0.207
anatomical structure formation involved in morphogenesis	GO:0048646	284	0.204	Mouse
negative regulation of tor signaling	GO:0032007	11	0.202
regulation of transferase activity	GO:0051338	355	0.201	Mouse
defense response	GO:0006952	315	0.198
single organism nuclear import	GO:1902593	104	0.195
tube closure	GO:0060606	3	0.191	Mouse
establishment of protein localization to membrane	GO:0090150	121	0.189
monosaccharide transport	GO:0015749	32	0.185	Mouse
regulation of purine nucleotide catabolic process	GO:0033121	205	0.180
positive regulation of protein phosphorylation	GO:0001934	313	0.178
protein localization to nucleus	GO:0034504	136	0.171
positive regulation of autophagy	GO:0010508	24	0.170	Fly
nucleoside catabolic process	GO:0009164	408	0.170
nuclear transport	GO:0051169	179	0.169
hexose transport	GO:0008645	30	0.168	Mouse
chemotaxis	GO:0006935	157	0.165
primary neural tube formation	GO:0014020	3	0.163	Mouse
determination of adult lifespan	GO:0008340	2	0.162	Fly
glucose transport	GO:0015758	30	0.160	Mouse
regulation of kinase activity	GO:0043549	314	0.159	Mouse
nervous system development	GO:0007399	293	0.156	Mouse
inflammatory response	GO:0006954	79	0.154
protein import	GO:0017038	130	0.153
regulation of nucleotide metabolic process	GO:0006140	269	0.150
cell projection organization	GO:0030030	252	0.147	Zebrafish Mouse
tor signaling	GO:0031929	39	0.141
heart development	GO:0007507	95	0.139	Mouse
protein targeting to nucleus	GO:0044744	104	0.134
cellular response to hypoxia	GO:0071456	51	0.133	Fly
cellular response to peptide hormone stimulus	GO:0071375	56	0.132	Fly
vesicle mediated transport	GO:0016192	371	0.130
cilium morphogenesis	GO:0060271	75	0.130	Zebrafish
response to decreased oxygen levels	GO:0036293	96	0.130	Fly
protein oligomerization	GO:0051259	173	0.127
response to organonitrogen compound	GO:0010243	156	0.127
circulatory system development	GO:0072359	262	0.124	Mouse
protein homooligomerization	GO:0051260	100	0.122
intracellular protein transport	GO:0006886	270	0.122
negative regulation of intracellular signal transduction	GO:1902532	183	0.122
neural tube formation	GO:0001841	3	0.121	Mouse
acute inflammatory response	GO:0002526	21	0.116
regulation of small gtpase mediated signal transduction	GO:0051056	156	0.112
cellular response to peptide	GO:1901653	59	0.111	Fly
taxis	GO:0042330	157	0.110
regulation of phosphatidylinositol 3 kinase signaling	GO:0014066	35	0.108
enzyme linked receptor protein signaling pathway	GO:0007167	303	0.108	Fly
regulation of protein serine threonine kinase activity	GO:0071900	179	0.105
tube development	GO:0035295	125	0.103	Mouse
protein ubiquitination	GO:0016567	314	0.102
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	181	0.099	Fly
response to nutrient	GO:0007584	20	0.099	Fly
cellular response to nitrogen compound	GO:1901699	144	0.098	Fly
regulation of protein kinase activity	GO:0045859	289	0.097	Mouse
regulation of map kinase activity	GO:0043405	108	0.097
negative regulation of cellular protein metabolic process	GO:0032269	353	0.096
negative regulation of multicellular organismal process	GO:0051241	317	0.095	Fly
phosphatidylinositol mediated signaling	GO:0048015	55	0.095
cellular response to decreased oxygen levels	GO:0036294	51	0.094	Fly
ribonucleoside triphosphate catabolic process	GO:0009203	391	0.093
female gamete generation	GO:0007292	2	0.093	Fly
protein import into nucleus	GO:0006606	104	0.092
nuclear import	GO:0051170	106	0.092
response to peptide	GO:1901652	65	0.092
epithelium development	GO:0060429	227	0.091	Mouse Fly
single organism cellular localization	GO:1902580	332	0.091
negative regulation of phosphorus metabolic process	GO:0010563	267	0.090
wnt signaling pathway	GO:0016055	156	0.089
tissue morphogenesis	GO:0048729	96	0.089	Mouse
regulation of rab protein signal transduction	GO:0032483	39	0.088
negative regulation of catalytic activity	GO:0043086	335	0.085
nucleocytoplasmic transport	GO:0006913	176	0.085
positive regulation of rab gtpase activity	GO:0032851	39	0.083
plasma membrane organization	GO:0007009	115	0.083
positive regulation of sequence specific dna binding transcription factor activity	GO:0051091	131	0.080
neural tube closure	GO:0001843	3	0.080	Mouse
regulation of rab gtpase activity	GO:0032313	39	0.079
cytoplasmic transport	GO:0016482	379	0.078
regulation of anatomical structure size	GO:0090066	101	0.076	Mouse Fly
positive regulation of phosphorylation	GO:0042327	394	0.076
response to abiotic stimulus	GO:0009628	336	0.075	Fly
regulation of cellular response to insulin stimulus	GO:1900076	17	0.074	Fly
regulation of mapk cascade	GO:0043408	262	0.073
maintenance of location in cell	GO:0051651	62	0.073
lipid metabolic process	GO:0006629	381	0.071	Fly
response to oxygen levels	GO:0070482	100	0.071	Fly
negative regulation of cell growth	GO:0030308	83	0.071	Fly
protein localization to plasma membrane	GO:0072659	93	0.070
apoptotic signaling pathway	GO:0097190	268	0.069
cellular response to oxygen levels	GO:0071453	55	0.069	Fly
phosphatidylinositol 3 kinase signaling	GO:0014065	48	0.067
cellular response to endogenous stimulus	GO:0071495	336	0.067	Fly
regulation of endocytosis	GO:0030100	72	0.066
membrane organization	GO:0061024	292	0.066
endomembrane system organization	GO:0010256	196	0.065
protein modification by small protein conjugation	GO:0032446	342	0.065
glucose import	GO:0046323	24	0.064	Mouse
innate immune response	GO:0045087	178	0.063
regulation of insulin receptor signaling pathway	GO:0046626	13	0.063	Fly
cilium assembly	GO:0042384	63	0.062
regulation of ras protein signal transduction	GO:0046578	155	0.061
inositol lipid mediated signaling	GO:0048017	55	0.061
protein targeting	GO:0006605	187	0.061
mapk cascade	GO:0000165	288	0.059
cellular response to organonitrogen compound	GO:0071417	124	0.055	Fly
regulation of cell growth	GO:0001558	135	0.055	Fly
negative regulation of phosphate metabolic process	GO:0045936	267	0.055
endosomal transport	GO:0016197	129	0.054
negative regulation of cilium assembly	GO:1902018	3	0.054
regulation of cell cycle	GO:0051726	393	0.053	Fly
regulation of epithelial cell proliferation	GO:0050678	113	0.052
negative regulation of epithelial cell proliferation	GO:0050680	48	0.051
signal transduction by phosphorylation	GO:0023014	297	0.050
autophagy	GO:0006914	88	0.050	Fly
cilium organization	GO:0044782	68	0.049
negative regulation of protein modification process	GO:0031400	200	0.048
protein heterooligomerization	GO:0051291	16	0.047
regulation of wnt signaling pathway	GO:0030111	123	0.046
negative regulation of protein phosphorylation	GO:0001933	140	0.045
chromatin organization	GO:0006325	351	0.045
morphogenesis of an epithelium	GO:0002009	60	0.045	Mouse
sodium ion transport	GO:0006814	61	0.044
negative regulation of mapk cascade	GO:0043409	56	0.044
epithelial cell proliferation	GO:0050673	128	0.044
negative regulation of map kinase activity	GO:0043407	27	0.043
regulation of sequence specific dna binding transcription factor activity	GO:0051090	211	0.042
negative regulation of developmental growth	GO:0048640	10	0.041	Fly
dna repair	GO:0006281	198	0.041
covalent chromatin modification	GO:0016569	254	0.040
negative regulation of protein serine threonine kinase activity	GO:0071901	57	0.040
negative regulation of nervous system development	GO:0051961	28	0.040
histone modification	GO:0016570	251	0.039
negative regulation of protein kinase b signaling	GO:0051898	17	0.039
protein catabolic process	GO:0030163	325	0.038
regulation of establishment of protein localization	GO:0070201	242	0.038
response to lipid	GO:0033993	206	0.038
positive regulation of nucleotide metabolic process	GO:0045981	230	0.037
peptidyl lysine modification	GO:0018205	144	0.037
regulation of protein kinase b signaling	GO:0051896	61	0.037
monovalent inorganic cation transport	GO:0015672	128	0.035	Mouse
regulation of protein catabolic process	GO:0042176	155	0.035
posttranscriptional regulation of gene expression	GO:0010608	213	0.035
response to other organism	GO:0051707	261	0.034
rho protein signal transduction	GO:0007266	26	0.034
negative regulation of cellular response to insulin stimulus	GO:1900077	8	0.034	Fly
positive chemotaxis	GO:0050918	33	0.034
regulation of growth	GO:0040008	165	0.033	Fly
cell cell signaling involved in cell fate commitment	GO:0045168	5	0.033
neuron differentiation	GO:0030182	138	0.033
negative regulation of transferase activity	GO:0051348	124	0.032
regulation of autophagy	GO:0010506	52	0.032	Fly
cell projection morphogenesis	GO:0048858	129	0.032	Zebrafish
regulation of cellular amino acid metabolic process	GO:0006521	6	0.031
positive regulation of transport	GO:0051050	336	0.031
intracellular receptor signaling pathway	GO:0030522	104	0.031
purine ribonucleoside metabolic process	GO:0046128	437	0.030
release of cytoplasmic sequestered nf kappab	GO:0008588	4	0.030
regulation of i kappab kinase nf kappab signaling	GO:0043122	162	0.030
positive regulation of programmed cell death	GO:0043068	249	0.030
neurogenesis	GO:0022008	169	0.029
chromatin modification	GO:0016568	298	0.029
organ growth	GO:0035265	12	0.028	Fly
negative regulation of phosphorylation	GO:0042326	174	0.028
cell projection assembly	GO:0030031	126	0.028
regulation of cell development	GO:0060284	161	0.028
regulation of cell cycle process	GO:0010564	266	0.028
negative regulation of hydrolase activity	GO:0051346	182	0.027
cell development	GO:0048468	328	0.027	Fly
maintenance of protein location	GO:0045185	57	0.027
cellular component assembly involved in morphogenesis	GO:0010927	73	0.027
response to nutrient levels	GO:0031667	81	0.027	Fly
cell fate determination	GO:0001709	3	0.026
regulation of cell differentiation	GO:0045595	393	0.026	Fly
regulation of innate immune response	GO:0045088	97	0.026
positive regulation of cellular component organization	GO:0051130	376	0.026
protein kinase b signaling	GO:0043491	69	0.026
system process	GO:0003008	349	0.026	Mouse
carbohydrate metabolic process	GO:0005975	207	0.025
regulation of cell morphogenesis	GO:0022604	153	0.025
negative regulation of protein transport	GO:0051224	75	0.025
regulation of defense response	GO:0031347	154	0.025
regulation of synapse assembly	GO:0051963	5	0.025
translation	GO:0006412	132	0.025
regulation of cellular component size	GO:0032535	82	0.025	Mouse Fly
regulation of cellular ketone metabolic process	GO:0010565	50	0.024
cellular amino acid metabolic process	GO:0006520	116	0.024
chordate embryonic development	GO:0043009	34	0.024	Mouse
negative regulation of kinase activity	GO:0033673	106	0.023
cell part morphogenesis	GO:0032990	137	0.023	Zebrafish
regulation of nervous system development	GO:0051960	88	0.023
regulation of protein localization to nucleus	GO:1900180	85	0.023
insulin like growth factor receptor signaling pathway	GO:0048009	13	0.023
positive regulation of cell death	GO:0010942	263	0.023
sensory perception of pain	GO:0019233	4	0.022
regulation of synaptic plasticity	GO:0048167	3	0.022
regulation of cellular response to stress	GO:0080135	244	0.022
regulation of vasculature development	GO:1901342	97	0.022
transmembrane transport	GO:0055085	399	0.022
growth	GO:0040007	202	0.021	Fly
cell cell signaling	GO:0007267	155	0.021
response to cytokine	GO:0034097	232	0.021
positive regulation of defense response	GO:0031349	87	0.021
regulation of cell projection organization	GO:0031344	107	0.021
regulation of response to external stimulus	GO:0032101	222	0.021
immune response	GO:0006955	307	0.021
single organism membrane organization	GO:0044802	268	0.021
negative regulation of response to external stimulus	GO:0032102	83	0.020
protein autophosphorylation	GO:0046777	123	0.020
reproductive process	GO:0022414	106	0.020	Fly
negative regulation of cell cycle	GO:0045786	193	0.020
cellular macromolecule catabolic process	GO:0044265	380	0.020
positive regulation of developmental process	GO:0051094	314	0.020
cell division	GO:0051301	168	0.020
defense response to virus	GO:0051607	71	0.020
extrinsic apoptotic signaling pathway	GO:0097191	119	0.020
locomotory behavior	GO:0007626	1	0.020
maintenance of protein location in cell	GO:0032507	56	0.019
positive regulation of apoptotic process	GO:0043065	246	0.019
response to external biotic stimulus	GO:0043207	261	0.019
positive regulation of rho gtpase activity	GO:0032321	56	0.019
regulation of anatomical structure morphogenesis	GO:0022603	286	0.019
response to bacterium	GO:0009617	144	0.019
amine metabolic process	GO:0009308	44	0.019
negative regulation of catabolic process	GO:0009895	104	0.019
multicellular organismal aging	GO:0010259	3	0.019	Fly
positive regulation of protein transport	GO:0051222	135	0.018
cellular amine metabolic process	GO:0044106	41	0.018
negative regulation of organ growth	GO:0046621	5	0.018	Fly
response to biotic stimulus	GO:0009607	276	0.018
startle response	GO:0001964	3	0.018
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.018
organelle assembly	GO:0070925	176	0.018
regulation of transporter activity	GO:0032409	82	0.018
regulation of transmembrane transport	GO:0034762	139	0.018
regulation of organelle assembly	GO:1902115	40	0.018
regulation of protein transport	GO:0051223	213	0.018
tube morphogenesis	GO:0035239	95	0.018	Mouse
cell fate commitment	GO:0045165	27	0.018
brain development	GO:0007420	97	0.018	Mouse
regulation of cell morphogenesis involved in differentiation	GO:0010769	83	0.018
epithelial tube morphogenesis	GO:0060562	38	0.018	Mouse
nitrogen compound transport	GO:0071705	191	0.017
negative regulation of cellular component organization	GO:0051129	235	0.017
limbic system development	GO:0021761	3	0.017	Mouse
neuron projection development	GO:0031175	106	0.017
cellular ketone metabolic process	GO:0042180	80	0.017
negative regulation of insulin receptor signaling pathway	GO:0046627	8	0.017	Fly
positive regulation of transcription from rna polymerase ii promoter during mitosis	GO:0046022	1	0.017
serine phosphorylation of stat protein	GO:0042501	4	0.017
synapse organization	GO:0050808	14	0.017	Mouse
post embryonic development	GO:0009791	2	0.016	Fly
regulation of synapse organization	GO:0050807	7	0.016
phagocytosis	GO:0006909	42	0.016
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	281	0.016
response to muramyl dipeptide	GO:0032495	4	0.016
protein maturation	GO:0051604	233	0.016
cell growth	GO:0016049	160	0.016	Fly
secretion	GO:0046903	254	0.016
negative regulation of protein kinase activity	GO:0006469	98	0.016
segmentation	GO:0035282	4	0.015
positive regulation of cell proliferation	GO:0008284	301	0.015
regulation of protein targeting	GO:1903533	91	0.015
muscle contraction	GO:0006936	73	0.015
endocytosis	GO:0006897	159	0.015
neurological system process	GO:0050877	163	0.015	Mouse
negative regulation of programmed cell death	GO:0043069	321	0.015
positive regulation of transcription during mitosis	GO:0045897	2	0.015
cellular protein catabolic process	GO:0044257	261	0.015
phospholipid metabolic process	GO:0006644	99	0.015
dna recombination	GO:0006310	77	0.015
cerebellum development	GO:0021549	2	0.015
generation of precursor metabolites and energy	GO:0006091	68	0.015
establishment or maintenance of microtubule cytoskeleton polarity	GO:0030951	2	0.015
histone acetylation	GO:0016573	93	0.014
amide transport	GO:0042886	76	0.014
maintenance of location	GO:0051235	112	0.014
regulation of protein stability	GO:0031647	87	0.014
negative regulation of cell cycle process	GO:0010948	121	0.014
cell morphogenesis	GO:0000902	296	0.014	Zebrafish
dephosphorylation	GO:0016311	209	0.014
positive regulation of i kappab kinase nf kappab signaling	GO:0043123	132	0.014
regulation of canonical wnt signaling pathway	GO:0060828	88	0.014
cellular macromolecular complex assembly	GO:0034622	324	0.014
positive regulation of protein catabolic process	GO:0045732	75	0.014
negative regulation of protein processing	GO:0010955	142	0.014
negative regulation of organelle organization	GO:0010639	126	0.014
regulation of multi organism process	GO:0043900	157	0.014
regulation of immune response	GO:0050776	201	0.014
negative regulation of protein localization to nucleus	GO:1900181	34	0.014
intraciliary transport	GO:0042073	7	0.014
detection of muramyl dipeptide	GO:0032498	1	0.014
intrinsic apoptotic signaling pathway	GO:0097193	127	0.014
endosome to lysosome transport	GO:0008333	21	0.014
internal protein amino acid acetylation	GO:0006475	101	0.014
muscle system process	GO:0003012	81	0.013
regulation of protein import into nucleus	GO:0042306	78	0.013
regulation of protein ubiquitination	GO:0031396	95	0.013
ion transmembrane transport	GO:0034220	338	0.013
response to uv	GO:0009411	73	0.013
cellular response to lipid	GO:0071396	127	0.013
regulation of nucleocytoplasmic transport	GO:0046822	98	0.013
negative regulation of dephosphorylation	GO:0035305	63	0.013
defense response to bacterium	GO:0042742	63	0.013
lymphocyte homeostasis	GO:0002260	4	0.013
ubiquitin dependent protein catabolic process	GO:0006511	206	0.013
peptide metabolic process	GO:0006518	51	0.013
response to virus	GO:0009615	126	0.013
jak stat cascade	GO:0007259	46	0.013
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	125	0.013
positive regulation of cell morphogenesis involved in differentiation	GO:0010770	50	0.013
positive regulation of cytoplasmic transport	GO:1903651	82	0.013
positive regulation of intracellular transport	GO:0032388	104	0.012
compound eye development	GO:0048749	1	0.012
i kappab kinase nf kappab signaling	GO:0007249	166	0.012
regulation of rho gtpase activity	GO:0032319	66	0.012
positive regulation of cellular amine metabolic process	GO:0033240	7	0.012
stem cell differentiation	GO:0048863	93	0.012
positive regulation of mapk cascade	GO:0043410	190	0.012
negative regulation of cellular amine metabolic process	GO:0033239	3	0.012
rna splicing	GO:0008380	131	0.012
positive regulation of protein kinase activity	GO:0045860	190	0.012
intraciliary retrograde transport	GO:0035721	3	0.012
metal ion transport	GO:0030001	272	0.012	Mouse
synapse assembly	GO:0007416	8	0.011
positive regulation of cell differentiation	GO:0045597	211	0.011
neural tube development	GO:0021915	9	0.011	Mouse
defense response to other organism	GO:0098542	129	0.011
modification dependent protein catabolic process	GO:0019941	209	0.011
negative regulation of transport	GO:0051051	176	0.011
positive regulation of intracellular protein transport	GO:0090316	76	0.011
regulation of protein secretion	GO:0050708	86	0.011
positive regulation of organelle organization	GO:0010638	195	0.011
dna damage checkpoint	GO:0000077	68	0.011
regulation of intracellular transport	GO:0032386	195	0.011
positive regulation of transferase activity	GO:0051347	227	0.011
positive regulation of protein localization to nucleus	GO:1900182	48	0.011
cellular response to cytokine stimulus	GO:0071345	181	0.011
regulation of synapse structure and activity	GO:0050803	7	0.011
reactive oxygen species metabolic process	GO:0072593	75	0.011	Fly
biological adhesion	GO:0022610	331	0.011
striated muscle contraction	GO:0006941	52	0.011
microtubule based process	GO:0007017	210	0.011
cell cycle phase transition	GO:0044770	173	0.011
nuclear migration	GO:0007097	1	0.011
sodium ion transmembrane transport	GO:0035725	59	0.011
regulation of cilium assembly	GO:1902017	6	0.011
response to axon injury	GO:0048678	1	0.011
negative regulation of viral process	GO:0048525	66	0.011
metencephalon development	GO:0022037	2	0.010
monocarboxylic acid metabolic process	GO:0032787	185	0.010
oxidation reduction process	GO:0055114	396	0.010
positive regulation of immune response	GO:0050778	159	0.010
response to drug	GO:0042493	81	0.010
regulation of meiosis	GO:0040020	3	0.010
modification dependent macromolecule catabolic process	GO:0043632	212	0.010
mitochondrion organization	GO:0007005	156	0.010
regulation of cell projection assembly	GO:0060491	47	0.010
cellular response to hormone stimulus	GO:0032870	125	0.010	Fly
central nervous system neuron axonogenesis	GO:0021955	3	0.010
negative regulation of immune system process	GO:0002683	136	0.010
single organism carbohydrate metabolic process	GO:0044723	193	0.010
regulation of cytoplasmic transport	GO:1903649	149	0.010
regulation of transmembrane transporter activity	GO:0022898	74	0.010

TSC1 disease predictions

Disease	DO term ID	Size	Probability
central nervous system disease	DOID:331	186	0.055
nervous system disease	DOID:863	431	0.055
neurodegenerative disease	DOID:1289	102	0.017
cancer	DOID:162	167	0.012
disease of cellular proliferation	DOID:14566	174	0.012
organ system cancer	DOID:0050686	164	0.012
tuberous sclerosis	DOID:13515	3	0.000

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