IMP: Integrative Multi-species Prediction

Homo sapiens

25 known processes

TSEN2

tRNA splicing endonuclease 2 homolog (S. cerevisiae)

(Aliases: MGC4440,SEN2,PCH2B,SEN2L,MGC2776)

HGNC: 28422
Ensembl: ENSG00000154743
MIM: 608753
Entrez: 80746
HPRD: 10576
UniProtKB: Q8NCE0
UniProtKB: A0A024R2H2

Process Predictions
Disease Predictions

TSEN2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
trna metabolic process	GO:0006399	35	0.167
ncrna metabolic process	GO:0034660	108	0.122
cellular amino acid metabolic process	GO:0006520	116	0.073
macromolecule methylation	GO:0043414	97	0.046
methylation	GO:0032259	106	0.044
cellular ketone metabolic process	GO:0042180	80	0.043
female gamete generation	GO:0007292	2	0.036
post embryonic development	GO:0009791	2	0.036
mitochondrion organization	GO:0007005	156	0.029
oxidation reduction process	GO:0055114	396	0.027
ncrna processing	GO:0034470	83	0.027
regulation of cellular ketone metabolic process	GO:0010565	50	0.027
nadh dehydrogenase complex assembly	GO:0010257	16	0.026
trna processing	GO:0008033	23	0.025
regulation of cellular amino acid metabolic process	GO:0006521	6	0.025
negative regulation of protein modification process	GO:0031400	200	0.024
single organism carbohydrate metabolic process	GO:0044723	193	0.024
carbohydrate metabolic process	GO:0005975	207	0.024
cellular macromolecular complex assembly	GO:0034622	324	0.022
trna modification	GO:0006400	10	0.022
organophosphate catabolic process	GO:0046434	430	0.021
glycoprotein metabolic process	GO:0009100	110	0.020
defense response	GO:0006952	315	0.020
cellular protein complex assembly	GO:0043623	188	0.020
microtubule based process	GO:0007017	210	0.020
regulation of protein localization	GO:0032880	296	0.019
determination of adult lifespan	GO:0008340	2	0.019
multicellular organismal aging	GO:0010259	3	0.019
organonitrogen compound biosynthetic process	GO:1901566	200	0.019
cell morphogenesis	GO:0000902	296	0.019
negative regulation of cellular protein metabolic process	GO:0032269	353	0.019
negative regulation of phosphorus metabolic process	GO:0010563	267	0.018
protein ubiquitination	GO:0016567	314	0.018
protein localization to organelle	GO:0033365	280	0.018
nucleic acid phosphodiester bond hydrolysis	GO:0090305	102	0.018
rna processing	GO:0006396	255	0.018
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.018
regulation of cytokine production	GO:0001817	232	0.018
cytoplasmic transport	GO:0016482	379	0.018
regulation of cellular response to stress	GO:0080135	244	0.018
carbohydrate derivative biosynthetic process	GO:1901137	207	0.017
protein glycosylation	GO:0006486	62	0.017
positive regulation of cytokine production	GO:0001819	167	0.017
negative regulation of catalytic activity	GO:0043086	335	0.017
negative regulation of cell proliferation	GO:0008285	228	0.017
negative regulation of protein metabolic process	GO:0051248	391	0.017
regulation of cell cycle process	GO:0010564	266	0.016
posttranscriptional regulation of gene expression	GO:0010608	213	0.016
negative regulation of phosphate metabolic process	GO:0045936	267	0.016
amine metabolic process	GO:0009308	44	0.016
mitotic cell cycle	GO:0000278	326	0.016
immune response	GO:0006955	307	0.016
mitochondrial respiratory chain complex assembly	GO:0033108	23	0.016
oogenesis	GO:0048477	2	0.016
actin filament based process	GO:0030029	224	0.015
negative regulation of intracellular signal transduction	GO:1902532	183	0.015
negative regulation of programmed cell death	GO:0043069	321	0.015
protein alkylation	GO:0008213	74	0.015
cellular amine metabolic process	GO:0044106	41	0.015
purine ribonucleoside metabolic process	GO:0046128	437	0.015
cellular component morphogenesis	GO:0032989	314	0.015
trna aminoacylation for mitochondrial protein translation	GO:0070127	3	0.014
positive regulation of cellular amine metabolic process	GO:0033240	7	0.014
segmentation	GO:0035282	4	0.014
negative regulation of apoptotic process	GO:0043066	316	0.014
protein methylation	GO:0006479	74	0.014
negative regulation of hydrolase activity	GO:0051346	182	0.014
macromolecule glycosylation	GO:0043413	63	0.014
glycoprotein biosynthetic process	GO:0009101	91	0.014
negative regulation of immune system process	GO:0002683	136	0.014
nucleotide catabolic process	GO:0009166	408	0.014
response to abiotic stimulus	GO:0009628	336	0.014
trna aminoacylation	GO:0043039	12	0.014
purine nucleoside triphosphate metabolic process	GO:0009144	412	0.014
dendritic spine morphogenesis	GO:0060997	3	0.013
generation of precursor metabolites and energy	GO:0006091	68	0.013
regulation of cell growth	GO:0001558	135	0.013
purine containing compound biosynthetic process	GO:0072522	88	0.013
growth	GO:0040007	202	0.013
cell projection organization	GO:0030030	252	0.013
microtubule cytoskeleton organization	GO:0000226	176	0.013
cell projection assembly	GO:0030031	126	0.013
histone lysine methylation	GO:0034968	50	0.013
glycosylation	GO:0070085	71	0.013
ribonucleoside triphosphate metabolic process	GO:0009199	412	0.013
regulation of growth	GO:0040008	165	0.013
rna modification	GO:0009451	27	0.013
sulfur compound metabolic process	GO:0006790	101	0.013
histone modification	GO:0016570	251	0.013
cilium morphogenesis	GO:0060271	75	0.013
protein maturation	GO:0051604	233	0.013
organelle fission	GO:0048285	149	0.012
lipid metabolic process	GO:0006629	381	0.012
regulation of cytoskeleton organization	GO:0051493	177	0.012
covalent chromatin modification	GO:0016569	254	0.012
compound eye development	GO:0048749	1	0.012
chromatin organization	GO:0006325	351	0.012
nucleoside triphosphate catabolic process	GO:0009143	394	0.012
positive regulation of secretion by cell	GO:1903532	108	0.012
cofactor metabolic process	GO:0051186	87	0.012
single organism cellular localization	GO:1902580	332	0.012
positive regulation of immune system process	GO:0002684	283	0.012
chromosome segregation	GO:0007059	114	0.012
positive regulation of phosphorylation	GO:0042327	394	0.012
adult locomotory behavior	GO:0008344	1	0.012
response to oxygen containing compound	GO:1901700	369	0.012
cell growth	GO:0016049	160	0.012
regulation of cell motility	GO:2000145	299	0.012
cellular macromolecule catabolic process	GO:0044265	380	0.012
positive regulation of hydrolase activity	GO:0051345	331	0.012
cell activation	GO:0001775	213	0.012
purine ribonucleoside catabolic process	GO:0046130	398	0.011
locomotory behavior	GO:0007626	1	0.011
innate immune response	GO:0045087	178	0.011
regulation of immune response	GO:0050776	201	0.011
maintenance of location	GO:0051235	112	0.011
positive regulation of cell proliferation	GO:0008284	301	0.011
negative regulation of cell death	GO:0060548	345	0.011
mitochondrial rna metabolic process	GO:0000959	15	0.011
cellular response to cytokine stimulus	GO:0071345	181	0.011
memory	GO:0007613	3	0.011
regulation of protein transport	GO:0051223	213	0.011
cell projection morphogenesis	GO:0048858	129	0.011
protein oligomerization	GO:0051259	173	0.011
regulation of proteolysis	GO:0030162	293	0.011
cytokine production	GO:0001816	247	0.011
actin cytoskeleton organization	GO:0030036	207	0.011
rna methylation	GO:0001510	18	0.011
response to nitrogen compound	GO:1901698	184	0.011
purine ribonucleoside triphosphate metabolic process	GO:0009205	411	0.011
ribonucleoside triphosphate catabolic process	GO:0009203	391	0.011
response to external biotic stimulus	GO:0043207	261	0.010
negative regulation of phosphorylation	GO:0042326	174	0.010
positive regulation of cellular component movement	GO:0051272	181	0.010
regulation of establishment of protein localization	GO:0070201	242	0.010
mitochondrial translation	GO:0032543	17	0.010
protein modification by small protein conjugation	GO:0032446	342	0.010
negative regulation of cell cycle process	GO:0010948	121	0.010
response to biotic stimulus	GO:0009607	276	0.010
positive regulation of cell motility	GO:2000147	177	0.010

TSEN2 disease predictions

Disease	DO term ID	Size	Probability
disease of metabolism	DOID:0014667	295	0.050
inherited metabolic disorder	DOID:655	242	0.045
congenital muscular dystrophy	DOID:0050557	22	0.018
muscular disease	DOID:0080000	114	0.018
myopathy	DOID:423	104	0.018
muscle tissue disease	DOID:66	113	0.018
muscular dystrophy	DOID:9884	51	0.018
musculoskeletal system disease	DOID:17	223	0.018
nervous system disease	DOID:863	431	0.016
central nervous system disease	DOID:331	186	0.016
primary ciliary dyskinesia	DOID:9562	27	0.011
disease of cellular proliferation	DOID:14566	174	0.010

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