| protein sumoylation | GO:0016925 | 25 | 1.000 | |
| protein modification by small protein conjugation | GO:0032446 | 342 | 1.000 | |
| negative regulation of transcription from rna polymerase ii promoter | GO:0000122 | 281 | 1.000 | |
| positive regulation of protein sumoylation | GO:0033235 | 7 | 1.000 | |
| histone modification | GO:0016570 | 251 | 0.999 | |
| covalent chromatin modification | GO:0016569 | 254 | 0.999 | |
| positive regulation of protein modification by small protein conjugation or removal | GO:1903322 | 61 | 0.998 | |
| chromatin organization | GO:0006325 | 351 | 0.997 | |
| chromatin modification | GO:0016568 | 298 | 0.995 | |
| regulation of protein sumoylation | GO:0033233 | 13 | 0.994 | |
| embryonic camera type eye development | GO:0031076 | 2 | 0.993 | |
| pml body organization | GO:0030578 | 2 | 0.990 | |
| positive regulation of developmental process | GO:0051094 | 314 | 0.990 | |
| cellular response to transforming growth factor beta stimulus | GO:0071560 | 94 | 0.988 | Fly |
| embryonic camera type eye morphogenesis | GO:0048596 | 2 | 0.987 | |
| response to transforming growth factor beta | GO:0071559 | 94 | 0.986 | Fly |
| regulation of protein ubiquitination | GO:0031396 | 95 | 0.986 | |
| response to abiotic stimulus | GO:0009628 | 336 | 0.982 | |
| regulation of protein modification by small protein conjugation or removal | GO:1903320 | 107 | 0.981 | |
| hemopoiesis | GO:0030097 | 180 | 0.979 | Fly |
| positive regulation of sequence specific dna binding transcription factor activity | GO:0051091 | 131 | 0.978 | Rat |
| macromolecule methylation | GO:0043414 | 97 | 0.975 | |
| regulation of ossification | GO:0030278 | 58 | 0.965 | |
| regulation of sequence specific dna binding transcription factor activity | GO:0051090 | 211 | 0.965 | Rat |
| histone methylation | GO:0016571 | 60 | 0.964 | |
| proteasomal protein catabolic process | GO:0010498 | 176 | 0.957 | Rat |
| positive regulation of apoptotic signaling pathway | GO:2001235 | 70 | 0.957 | |
| definitive hemopoiesis | GO:0060216 | 2 | 0.955 | |
| cellular response to dna damage stimulus | GO:0006974 | 379 | 0.954 | Fly |
| negative regulation of sequence specific dna binding transcription factor activity | GO:0043433 | 89 | 0.951 | |
| cellular response to organic cyclic compound | GO:0071407 | 127 | 0.946 | |
| regulation of cellular response to stress | GO:0080135 | 244 | 0.943 | |
| regulation of peptidase activity | GO:0052547 | 180 | 0.942 | |
| pituitary gland development | GO:0021983 | 2 | 0.934 | |
| osteoblast differentiation | GO:0001649 | 92 | 0.919 | |
| pharynx development | GO:0060465 | 1 | 0.918 | Worm |
| nucleocytoplasmic transport | GO:0006913 | 176 | 0.917 | Fly |
| negative regulation of protein metabolic process | GO:0051248 | 391 | 0.917 | |
| retina layer formation | GO:0010842 | 3 | 0.915 | |
| response to growth factor | GO:0070848 | 205 | 0.914 | Fly |
| compound eye development | GO:0048749 | 1 | 0.913 | |
| regulation of osteoblast differentiation | GO:0045667 | 38 | 0.908 | |
| positive regulation of cysteine type endopeptidase activity involved in apoptotic process | GO:0043280 | 69 | 0.903 | |
| regulation of endopeptidase activity | GO:0052548 | 170 | 0.901 | |
| regulation of cellular ketone metabolic process | GO:0010565 | 50 | 0.900 | |
| regulation of cell differentiation | GO:0045595 | 393 | 0.899 | Fly |
| post embryonic development | GO:0009791 | 2 | 0.897 | Worm Fly |
| embryo development | GO:0009790 | 123 | 0.893 | Worm Fly |
| activation of cysteine type endopeptidase activity involved in apoptotic process | GO:0006919 | 49 | 0.892 | |
| ossification | GO:0001503 | 121 | 0.877 | |
| negative regulation of protein ubiquitination | GO:0031397 | 35 | 0.865 | |
| posttranscriptional regulation of gene expression | GO:0010608 | 213 | 0.860 | |
| response to lipid | GO:0033993 | 206 | 0.856 | |
| cellular response to endogenous stimulus | GO:0071495 | 336 | 0.855 | Fly |
| response to ionizing radiation | GO:0010212 | 65 | 0.854 | |
| modification dependent macromolecule catabolic process | GO:0043632 | 212 | 0.830 | Rat |
| proteasome mediated ubiquitin dependent protein catabolic process | GO:0043161 | 156 | 0.819 | Rat |
| cell type specific apoptotic process | GO:0097285 | 125 | 0.819 | |
| embryonic eye morphogenesis | GO:0048048 | 2 | 0.804 | |
| negative regulation of protein modification process | GO:0031400 | 200 | 0.802 | |
| somatic stem cell maintenance | GO:0035019 | 4 | 0.801 | |
| cellular response to growth factor stimulus | GO:0071363 | 197 | 0.779 | Fly |
| protein ubiquitination | GO:0016567 | 314 | 0.775 | Rat |
| negative regulation of binding | GO:0051100 | 57 | 0.774 | |
| viral release from host cell | GO:0019076 | 21 | 0.774 | |
| protein stabilization | GO:0050821 | 64 | 0.768 | |
| apoptotic signaling pathway | GO:0097190 | 268 | 0.768 | |
| hematopoietic or lymphoid organ development | GO:0048534 | 186 | 0.763 | Fly |
| negative regulation of protein modification by small protein conjugation or removal | GO:1903321 | 41 | 0.758 | |
| protein maturation | GO:0051604 | 233 | 0.755 | |
| positive regulation of cellular component organization | GO:0051130 | 376 | 0.753 | |
| mesenchymal cell development | GO:0014031 | 50 | 0.740 | |
| cellular protein catabolic process | GO:0044257 | 261 | 0.728 | Rat |
| androgen receptor signaling pathway | GO:0030521 | 34 | 0.720 | |
| regulation of intracellular transport | GO:0032386 | 195 | 0.716 | |
| neural crest cell development | GO:0014032 | 3 | 0.708 | |
| cellular response to steroid hormone stimulus | GO:0071383 | 37 | 0.701 | |
| regulation of histone modification | GO:0031056 | 47 | 0.696 | |
| cellular response to cytokine stimulus | GO:0071345 | 181 | 0.693 | |
| neurogenesis | GO:0022008 | 169 | 0.686 | |
| intrinsic apoptotic signaling pathway in response to dna damage | GO:0008630 | 50 | 0.685 | |
| positive regulation of proteasomal protein catabolic process | GO:1901800 | 35 | 0.682 | |
| protein polyubiquitination | GO:0000209 | 110 | 0.681 | |
| lens development in camera type eye | GO:0002088 | 2 | 0.674 | |
| histone deacetylation | GO:0016575 | 32 | 0.674 | |
| nervous system development | GO:0007399 | 293 | 0.671 | |
| protein targeting | GO:0006605 | 187 | 0.669 | Fly |
| regulation of binding | GO:0051098 | 111 | 0.654 | |
| positive regulation of cell proliferation | GO:0008284 | 301 | 0.650 | |
| regulation of cysteine type endopeptidase activity involved in apoptotic process | GO:0043281 | 116 | 0.640 | |
| negative regulation of bmp signaling pathway | GO:0030514 | 17 | 0.640 | |
| nuclear export | GO:0051168 | 69 | 0.636 | |
| defense response to other organism | GO:0098542 | 129 | 0.620 | |
| regulation of viral transcription | GO:0046782 | 34 | 0.620 | |
| neuron differentiation | GO:0030182 | 138 | 0.612 | |
| positive regulation of cell death | GO:0010942 | 263 | 0.606 | |
| intracellular protein transport | GO:0006886 | 270 | 0.597 | Fly |
| regulation of protein stability | GO:0031647 | 87 | 0.594 | |
| positive regulation of peptidase activity | GO:0010952 | 88 | 0.594 | |
| immune system development | GO:0002520 | 195 | 0.590 | Fly |
| central nervous system neuron development | GO:0021954 | 7 | 0.587 | |
| transmembrane transport | GO:0055085 | 399 | 0.585 | |
| regulation of anatomical structure morphogenesis | GO:0022603 | 286 | 0.580 | |
| smad protein signal transduction | GO:0060395 | 10 | 0.576 | |
| regulation of membrane permeability | GO:0090559 | 25 | 0.566 | |
| defense response | GO:0006952 | 315 | 0.562 | |
| methylation | GO:0032259 | 106 | 0.561 | |
| central nervous system development | GO:0007417 | 123 | 0.552 | |
| negative regulation of glial cell proliferation | GO:0060253 | 2 | 0.549 | |
| regulation of cytokine mediated signaling pathway | GO:0001959 | 41 | 0.537 | |
| protein targeting to nucleus | GO:0044744 | 104 | 0.537 | Fly |
| protein methylation | GO:0006479 | 74 | 0.528 | |
| response to gamma radiation | GO:0010332 | 14 | 0.525 | |
| regulation of apoptotic signaling pathway | GO:2001233 | 175 | 0.522 | |
| regulation of transforming growth factor beta receptor signaling pathway | GO:0017015 | 48 | 0.519 | |
| activation of cysteine type endopeptidase activity | GO:0097202 | 57 | 0.519 | |
| transforming growth factor beta receptor signaling pathway | GO:0007179 | 76 | 0.519 | |
| positive regulation of apoptotic process | GO:0043065 | 246 | 0.513 | |
| proteolysis involved in cellular protein catabolic process | GO:0051603 | 244 | 0.505 | Rat |
| regulation of proteolysis | GO:0030162 | 293 | 0.505 | |
| response to organic cyclic compound | GO:0014070 | 204 | 0.499 | |
| response to hypoxia | GO:0001666 | 96 | 0.496 | |
| maintenance of location | GO:0051235 | 112 | 0.493 | |
| chromatin assembly or disassembly | GO:0006333 | 78 | 0.493 | |
| positive regulation of tooth mineralization | GO:0070172 | 2 | 0.492 | |
| cellular ketone metabolic process | GO:0042180 | 80 | 0.486 | |
| response to radiation | GO:0009314 | 151 | 0.482 | |
| nuclear transport | GO:0051169 | 179 | 0.471 | Fly |
| immune effector process | GO:0002252 | 159 | 0.471 | |
| response to alcohol | GO:0097305 | 64 | 0.470 | |
| positive regulation of mapk cascade | GO:0043410 | 190 | 0.469 | |
| response to oxygen levels | GO:0070482 | 100 | 0.469 | |
| regulation of stem cell differentiation | GO:2000736 | 56 | 0.468 | |
| modification dependent protein catabolic process | GO:0019941 | 209 | 0.462 | Rat |
| regulation of dna binding | GO:0051101 | 37 | 0.461 | |
| locomotory behavior | GO:0007626 | 1 | 0.460 | |
| negative regulation of intracellular steroid hormone receptor signaling pathway | GO:0033144 | 18 | 0.456 | |
| cellular response to hormone stimulus | GO:0032870 | 125 | 0.456 | |
| regulation of proteolysis involved in cellular protein catabolic process | GO:1903050 | 91 | 0.455 | |
| regulation of chromatin modification | GO:1903308 | 51 | 0.453 | |
| lens morphogenesis in camera type eye | GO:0002089 | 2 | 0.451 | |
| determination of adult lifespan | GO:0008340 | 2 | 0.449 | |
| regulation of cell cycle | GO:0051726 | 393 | 0.441 | Zebrafish Fly |
| positive regulation of proteolysis | GO:0045862 | 142 | 0.439 | |
| homeostasis of number of cells | GO:0048872 | 40 | 0.437 | Zebrafish |
| protein deacetylation | GO:0006476 | 38 | 0.437 | |
| regulation of chromosome organization | GO:0033044 | 103 | 0.436 | |
| ribonucleoside monophosphate metabolic process | GO:0009161 | 187 | 0.429 | |
| growth | GO:0040007 | 202 | 0.427 | |
| mapk cascade | GO:0000165 | 288 | 0.425 | |
| organ morphogenesis | GO:0009887 | 147 | 0.421 | |
| negative regulation of cellular protein metabolic process | GO:0032269 | 353 | 0.413 | |
| single organism nuclear import | GO:1902593 | 104 | 0.407 | Fly |
| zymogen activation | GO:0031638 | 70 | 0.400 | |
| apoptotic mitochondrial changes | GO:0008637 | 57 | 0.399 | |
| ameboidal type cell migration | GO:0001667 | 135 | 0.394 | |
| positive regulation of phosphorylation | GO:0042327 | 394 | 0.393 | |
| regulation of transmembrane transporter activity | GO:0022898 | 74 | 0.393 | |
| dna damage response signal transduction resulting in transcription | GO:0042772 | 12 | 0.392 | |
| positive regulation of cysteine type endopeptidase activity | GO:2001056 | 79 | 0.392 | |
| dna packaging | GO:0006323 | 77 | 0.389 | |
| negative regulation of cell death | GO:0060548 | 345 | 0.386 | |
| glycosyl compound catabolic process | GO:1901658 | 413 | 0.384 | |
| negative regulation of viral release from host cell | GO:1902187 | 12 | 0.381 | |
| regulation of intracellular steroid hormone receptor signaling pathway | GO:0033143 | 32 | 0.380 | Rat |
| positive regulation of hydrolase activity | GO:0051345 | 331 | 0.377 | |
| response to hormone | GO:0009725 | 175 | 0.375 | |
| signal transduction by phosphorylation | GO:0023014 | 297 | 0.374 | |
| regulation of cellular response to growth factor stimulus | GO:0090287 | 76 | 0.373 | |
| cellular response to ionizing radiation | GO:0071479 | 32 | 0.372 | |
| positive regulation of organelle organization | GO:0010638 | 195 | 0.371 | |
| multi organism cellular process | GO:0044764 | 156 | 0.366 | |
| chromatin assembly | GO:0031497 | 61 | 0.366 | |
| cell fate determination | GO:0001709 | 3 | 0.365 | |
| positive regulation of cellular protein catabolic process | GO:1903364 | 37 | 0.363 | |
| negative regulation of protein catabolic process | GO:0042177 | 59 | 0.363 | |
| blood vessel morphogenesis | GO:0048514 | 162 | 0.362 | |
| negative regulation of myotube differentiation | GO:0010832 | 4 | 0.358 | |
| protein dna complex assembly | GO:0065004 | 64 | 0.354 | |
| response to other organism | GO:0051707 | 261 | 0.351 | |
| central nervous system neuron axonogenesis | GO:0021955 | 3 | 0.348 | |
| generation of neurons | GO:0048699 | 152 | 0.341 | |
| negative regulation of chromatin modification | GO:1903309 | 21 | 0.341 | |
| response to external biotic stimulus | GO:0043207 | 261 | 0.334 | |
| viral gene expression | GO:0019080 | 35 | 0.331 | |
| regulation of protein transport | GO:0051223 | 213 | 0.328 | |
| microtubule cytoskeleton organization | GO:0000226 | 176 | 0.322 | Yeast |
| response to biotic stimulus | GO:0009607 | 276 | 0.319 | |
| cytoplasmic transport | GO:0016482 | 379 | 0.318 | Fly |
| positive regulation of growth | GO:0045927 | 58 | 0.315 | |
| blood circulation | GO:0008015 | 113 | 0.312 | |
| protein alkylation | GO:0008213 | 74 | 0.312 | |
| peptidyl lysine acetylation | GO:0018394 | 101 | 0.308 | |
| cellular response to tumor necrosis factor | GO:0071356 | 63 | 0.302 | |
| signal transduction in response to dna damage | GO:0042770 | 57 | 0.302 | |
| connective tissue development | GO:0061448 | 39 | 0.302 | |
| regulation of cysteine type endopeptidase activity | GO:2000116 | 127 | 0.297 | |
| protein catabolic process | GO:0030163 | 325 | 0.296 | Rat |
| regulation of viral release from host cell | GO:1902186 | 20 | 0.293 | |
| intrinsic apoptotic signaling pathway | GO:0097193 | 127 | 0.291 | |
| purine nucleoside catabolic process | GO:0006152 | 398 | 0.291 | |
| regulation of viral process | GO:0050792 | 103 | 0.290 | |
| regulation of ion transmembrane transport | GO:0034765 | 132 | 0.290 | |
| regulation of cellular protein catabolic process | GO:1903362 | 96 | 0.289 | |
| cellular response to lipid | GO:0071396 | 127 | 0.288 | |
| regulation of growth | GO:0040008 | 165 | 0.286 | |
| negative regulation of mitotic cell cycle | GO:0045930 | 102 | 0.276 | Fly |
| calcium ion transport | GO:0006816 | 147 | 0.276 | |
| cellular response to nitrogen compound | GO:1901699 | 144 | 0.274 | |
| negative regulation of transcription by competitive promoter binding | GO:0010944 | 8 | 0.273 | |
| gland development | GO:0048732 | 48 | 0.273 | Fly |
| protein modification by small protein removal | GO:0070646 | 92 | 0.272 | |
| positive regulation of stress activated protein kinase signaling cascade | GO:0070304 | 61 | 0.269 | |
| protein deacylation | GO:0035601 | 39 | 0.267 | |
| regulation of neuron death | GO:1901214 | 56 | 0.265 | |
| response to cytokine | GO:0034097 | 232 | 0.264 | |
| regulation of symbiosis encompassing mutualism through parasitism | GO:0043903 | 109 | 0.263 | |
| multicellular organismal aging | GO:0010259 | 3 | 0.263 | |
| protein import into nucleus | GO:0006606 | 104 | 0.261 | Fly |
| regulation of transcription involved in g2 m transition of mitotic cell cycle | GO:0000117 | 1 | 0.260 | |
| mesenchymal cell differentiation | GO:0048762 | 52 | 0.259 | |
| positive regulation of programmed cell death | GO:0043068 | 249 | 0.259 | |
| neuron fate commitment | GO:0048663 | 2 | 0.258 | |
| bmp signaling pathway | GO:0030509 | 49 | 0.254 | |
| extrinsic apoptotic signaling pathway | GO:0097191 | 119 | 0.251 | |
| dna repair | GO:0006281 | 198 | 0.251 | |
| ubiquitin dependent protein catabolic process | GO:0006511 | 206 | 0.251 | Rat |
| intracellular steroid hormone receptor signaling pathway | GO:0030518 | 61 | 0.249 | Rat |
| regulation of cell growth | GO:0001558 | 135 | 0.249 | |
| skeletal system development | GO:0001501 | 79 | 0.246 | |
| viral life cycle | GO:0019058 | 132 | 0.245 | |
| dna modification | GO:0006304 | 27 | 0.243 | |
| protein ubiquitination involved in ubiquitin dependent protein catabolic process | GO:0042787 | 37 | 0.239 | |
| negative regulation of chromosome organization | GO:2001251 | 48 | 0.237 | |
| regulation of androgen receptor signaling pathway | GO:0060765 | 18 | 0.237 | |
| epidermis morphogenesis | GO:0048730 | 3 | 0.237 | |
| regulation of multicellular organism growth | GO:0040014 | 8 | 0.235 | |
| regulation of protein ubiquitination involved in ubiquitin dependent protein catabolic process | GO:2000058 | 7 | 0.232 | |
| regulation of stress activated mapk cascade | GO:0032872 | 84 | 0.231 | |
| regulation of gtp catabolic process | GO:0033124 | 180 | 0.228 | |
| iris morphogenesis | GO:0061072 | 2 | 0.227 | |
| negative regulation of apoptotic process | GO:0043066 | 316 | 0.226 | |
| digestive tract development | GO:0048565 | 75 | 0.222 | Worm |
| response to steroid hormone | GO:0048545 | 80 | 0.222 | |
| interspecies interaction between organisms | GO:0044419 | 156 | 0.222 | |
| response to toxic substance | GO:0009636 | 37 | 0.219 | |
| regulation of protein binding | GO:0043393 | 66 | 0.219 | |
| trophectodermal cell differentiation | GO:0001829 | 3 | 0.219 | |
| protein k11 linked ubiquitination | GO:0070979 | 24 | 0.219 | |
| cation transport | GO:0006812 | 331 | 0.218 | |
| regulation of angiogenesis | GO:0045765 | 92 | 0.216 | |
| regulation of synaptic plasticity | GO:0048167 | 3 | 0.216 | |
| regulation of wnt signaling pathway | GO:0030111 | 123 | 0.216 | |
| purine ribonucleoside metabolic process | GO:0046128 | 437 | 0.213 | |
| regulation of muscle cell differentiation | GO:0051147 | 31 | 0.213 | |
| regulation of transmembrane receptor protein serine threonine kinase signaling pathway | GO:0090092 | 90 | 0.212 | |
| developmental growth | GO:0048589 | 48 | 0.212 | |
| regulation of male gonad development | GO:2000018 | 4 | 0.212 | |
| regulation of lipid transport by regulation of transcription from rna polymerase ii promoter | GO:0072367 | 4 | 0.210 | |
| embryonic morphogenesis | GO:0048598 | 85 | 0.210 | Fly |
| regulation of transferase activity | GO:0051338 | 355 | 0.210 | |
| jnk cascade | GO:0007254 | 80 | 0.209 | |
| positive regulation of cell differentiation | GO:0045597 | 211 | 0.209 | |
| regulation of keratinocyte apoptotic process | GO:1902172 | 1 | 0.207 | |
| pattern specification process | GO:0007389 | 43 | 0.207 | Worm Fly |
| chromosome condensation | GO:0030261 | 15 | 0.206 | |
| lipid storage | GO:0019915 | 28 | 0.205 | |
| regulation of cardiac muscle cell proliferation | GO:0060043 | 4 | 0.204 | |
| positive regulation of osteoblast differentiation | GO:0045669 | 23 | 0.204 | |
| endodermal cell fate specification | GO:0001714 | 4 | 0.204 | |
| regulation of mitotic cell cycle phase transition | GO:1901990 | 118 | 0.203 | Fly |
| common partner smad protein phosphorylation | GO:0007182 | 3 | 0.203 | |
| dna integrity checkpoint | GO:0031570 | 71 | 0.203 | Fly |
| signal transduction by p53 class mediator | GO:0072331 | 72 | 0.203 | |
| positive regulation of apoptotic process involved in mammary gland involution | GO:0060058 | 1 | 0.202 | |
| response to estrogen | GO:0043627 | 47 | 0.199 | |
| cellular amino acid metabolic process | GO:0006520 | 116 | 0.195 | |
| negative regulation of cellular protein catabolic process | GO:1903363 | 38 | 0.195 | |
| regulation of proteasomal protein catabolic process | GO:0061136 | 87 | 0.195 | |
| head development | GO:0060322 | 108 | 0.195 | |
| negative regulation of phosphorus metabolic process | GO:0010563 | 267 | 0.193 | |
| positive regulation of odontogenesis | GO:0042482 | 3 | 0.193 | |
| response to virus | GO:0009615 | 126 | 0.192 | |
| multi organism metabolic process | GO:0044033 | 41 | 0.192 | |
| cellular modified amino acid metabolic process | GO:0006575 | 64 | 0.191 | |
| negative regulation of cytokine mediated signaling pathway | GO:0001960 | 22 | 0.190 | |
| embryo development ending in birth or egg hatching | GO:0009792 | 34 | 0.190 | Worm Fly |
| regulation of b cell differentiation | GO:0045577 | 2 | 0.189 | |
| regulation of jnk cascade | GO:0046328 | 73 | 0.187 | |
| positive regulation of nucleotide metabolic process | GO:0045981 | 230 | 0.186 | |
| eye development | GO:0001654 | 42 | 0.185 | |
| definitive erythrocyte differentiation | GO:0060318 | 2 | 0.184 | |
| negative regulation of locomotion | GO:0040013 | 118 | 0.184 | |
| rna polymerase ii transcriptional preinitiation complex assembly | GO:0051123 | 4 | 0.183 | |
| positive regulation of nf kappab transcription factor activity | GO:0051092 | 81 | 0.183 | |
| positive regulation of catabolic process | GO:0009896 | 310 | 0.182 | |
| positive regulation of apoptotic process involved in morphogenesis | GO:1902339 | 1 | 0.181 | |
| cell fate specification | GO:0001708 | 8 | 0.181 | |
| positive regulation of proteolysis involved in cellular protein catabolic process | GO:1903052 | 35 | 0.180 | |
| symbiosis encompassing mutualism through parasitism | GO:0044403 | 156 | 0.179 | |
| positive regulation of chromosome organization | GO:2001252 | 41 | 0.178 | |
| central nervous system projection neuron axonogenesis | GO:0021952 | 3 | 0.178 | |
| positive regulation of cellular component biogenesis | GO:0044089 | 158 | 0.177 | |
| purine ribonucleoside triphosphate metabolic process | GO:0009205 | 411 | 0.175 | |
| regulation of immune effector process | GO:0002697 | 91 | 0.174 | |
| negative regulation of cellular component organization | GO:0051129 | 235 | 0.173 | |
| positive regulation of intrinsic apoptotic signaling pathway | GO:2001244 | 28 | 0.170 | |
| regulation of intrinsic apoptotic signaling pathway | GO:2001242 | 72 | 0.168 | |
| transmembrane receptor protein serine threonine kinase signaling pathway | GO:0007178 | 125 | 0.168 | |
| positive regulation of developmental growth | GO:0048639 | 16 | 0.168 | |
| regulation of mapk cascade | GO:0043408 | 262 | 0.165 | |
| negative regulation of cell migration | GO:0030336 | 102 | 0.165 | |
| negative regulation of cellular amine metabolic process | GO:0033239 | 3 | 0.165 | |
| hindbrain development | GO:0030902 | 3 | 0.164 | |
| negative regulation of androgen receptor signaling pathway | GO:0060766 | 10 | 0.163 | |
| camera type eye development | GO:0043010 | 25 | 0.162 | |
| sensory organ morphogenesis | GO:0090596 | 21 | 0.160 | |
| negative regulation of immune response | GO:0050777 | 40 | 0.159 | |
| regulation of protein maturation | GO:1903317 | 150 | 0.158 | |
| positive regulation of male gonad development | GO:2000020 | 3 | 0.158 | |
| innate immune response | GO:0045087 | 178 | 0.156 | |
| chromosome segregation | GO:0007059 | 114 | 0.156 | Fly |
| rhythmic behavior | GO:0007622 | 2 | 0.156 | |
| regulation of response to dna damage stimulus | GO:2001020 | 94 | 0.155 | |
| dna damage checkpoint | GO:0000077 | 68 | 0.155 | Fly |
| negative regulation of protein maturation | GO:1903318 | 142 | 0.154 | |
| meiotic chromosome segregation | GO:0045132 | 4 | 0.153 | Fly |
| metal ion transport | GO:0030001 | 272 | 0.153 | |
| chordate embryonic development | GO:0043009 | 34 | 0.153 | |
| negative regulation of organelle organization | GO:0010639 | 126 | 0.150 | |
| protein acetylation | GO:0006473 | 116 | 0.150 | |
| protein oligomerization | GO:0051259 | 173 | 0.149 | |
| regulation of erythrocyte differentiation | GO:0045646 | 17 | 0.149 | |
| tube development | GO:0035295 | 125 | 0.149 | Worm |
| regulation of leukocyte differentiation | GO:1902105 | 61 | 0.146 | |
| dna damage response detection of dna damage | GO:0042769 | 3 | 0.146 | |
| intracellular receptor signaling pathway | GO:0030522 | 104 | 0.145 | Rat |
| cell fate commitment | GO:0045165 | 27 | 0.145 | |
| negative regulation of multicellular organismal process | GO:0051241 | 317 | 0.144 | Worm Fly |
| regulation of response to external stimulus | GO:0032101 | 222 | 0.144 | |
| cartilage development involved in endochondral bone morphogenesis | GO:0060351 | 2 | 0.144 | |
| lymphocyte differentiation | GO:0030098 | 35 | 0.144 | |
| positive regulation of endopeptidase activity | GO:0010950 | 84 | 0.143 | |
| regulation of protein localization | GO:0032880 | 296 | 0.143 | Worm |
| negative regulation of catalytic activity | GO:0043086 | 335 | 0.143 | |
| negative regulation of intracellular transport | GO:0032387 | 60 | 0.143 | |
| regulation of protein export from nucleus | GO:0046825 | 15 | 0.140 | |
| positive regulation of stress activated mapk cascade | GO:0032874 | 60 | 0.139 | |
| positive regulation of transferase activity | GO:0051347 | 227 | 0.139 | |
| gene silencing | GO:0016458 | 49 | 0.138 | |
| histone lysine methylation | GO:0034968 | 50 | 0.138 | |
| cellular response to oxidative stress | GO:0034599 | 85 | 0.137 | |
| protein processing | GO:0016485 | 226 | 0.136 | |
| positive regulation of multicellular organism growth | GO:0040018 | 6 | 0.136 | |
| neuron death | GO:0070997 | 65 | 0.135 | |
| embryonic retina morphogenesis in camera type eye | GO:0060059 | 1 | 0.132 | |
| protein acylation | GO:0043543 | 138 | 0.132 | |
| erythrocyte differentiation | GO:0030218 | 28 | 0.132 | |
| positive regulation of viral process | GO:0048524 | 37 | 0.131 | |
| regulation of protein catabolic process | GO:0042176 | 155 | 0.130 | |
| regulation of kinase activity | GO:0043549 | 314 | 0.128 | |
| embryonic organ development | GO:0048568 | 36 | 0.128 | |
| protein deubiquitination | GO:0016579 | 79 | 0.127 | |
| regulation of nucleoside metabolic process | GO:0009118 | 209 | 0.127 | |
| amine metabolic process | GO:0009308 | 44 | 0.127 | |
| bone development | GO:0060348 | 26 | 0.126 | |
| positive regulation of protein ubiquitination | GO:0031398 | 53 | 0.126 | |
| type i interferon signaling pathway | GO:0060337 | 11 | 0.126 | |
| double strand break repair | GO:0006302 | 101 | 0.123 | |
| dna conformation change | GO:0071103 | 113 | 0.123 | |
| regulation of cellular amine metabolic process | GO:0033238 | 11 | 0.122 | |
| positive regulation of dna binding | GO:0043388 | 17 | 0.121 | |
| reproductive system development | GO:0061458 | 56 | 0.120 | Worm |
| regulation of stress activated protein kinase signaling cascade | GO:0070302 | 85 | 0.120 | |
| regulation of protein complex assembly | GO:0043254 | 147 | 0.120 | |
| response to decreased oxygen levels | GO:0036293 | 96 | 0.119 | |
| nucleoside monophosphate metabolic process | GO:0009123 | 191 | 0.117 | |
| regulation of cell fate commitment | GO:0010453 | 7 | 0.117 | |
| positive regulation of binding | GO:0051099 | 45 | 0.116 | |
| cellular component morphogenesis | GO:0032989 | 314 | 0.115 | |
| cellular senescence | GO:0090398 | 34 | 0.115 | |
| response to wounding | GO:0009611 | 168 | 0.114 | |
| embryonic organ morphogenesis | GO:0048562 | 24 | 0.114 | |
| protein k48 linked ubiquitination | GO:0070936 | 38 | 0.114 | |
| epithelial to mesenchymal transition | GO:0001837 | 48 | 0.113 | |
| positive regulation of histone modification | GO:0031058 | 29 | 0.112 | |
| regulation of interleukin 2 secretion | GO:1900040 | 2 | 0.112 | |
| regulation of gene silencing | GO:0060968 | 24 | 0.111 | |
| positive regulation of transforming growth factor beta receptor signaling pathway | GO:0030511 | 12 | 0.109 | |
| generation of precursor metabolites and energy | GO:0006091 | 68 | 0.108 | |
| tissue morphogenesis | GO:0048729 | 96 | 0.108 | Fly |
| startle response | GO:0001964 | 3 | 0.108 | |
| single organism membrane organization | GO:0044802 | 268 | 0.108 | |
| anterior posterior pattern specification | GO:0009952 | 9 | 0.108 | Worm |
| intracellular signal transduction involved in g1 dna damage checkpoint | GO:1902400 | 10 | 0.108 | |
| regulation of ubiquitin protein transferase activity | GO:0051438 | 28 | 0.108 | |
| protein desumoylation | GO:0016926 | 4 | 0.107 | |
| regulation of cell development | GO:0060284 | 161 | 0.106 | |
| positive regulation of mesenchymal stem cell differentiation | GO:2000741 | 4 | 0.105 | |
| sex differentiation | GO:0007548 | 45 | 0.104 | Worm |
| negative regulation of viral process | GO:0048525 | 66 | 0.104 | |
| regulation of bmp signaling pathway | GO:0030510 | 27 | 0.104 | |
| protein export from nucleus | GO:0006611 | 29 | 0.102 | |
| purine nucleoside triphosphate metabolic process | GO:0009144 | 412 | 0.102 | |
| positive regulation of protein catabolic process | GO:0045732 | 75 | 0.102 | |
| leukocyte differentiation | GO:0002521 | 98 | 0.100 | |
| nucleus organization | GO:0006997 | 28 | 0.100 | |
| rna processing | GO:0006396 | 255 | 0.100 | |
| divalent metal ion transport | GO:0070838 | 152 | 0.100 | |
| regulation of transporter activity | GO:0032409 | 82 | 0.100 | |
| positive regulation of jnk cascade | GO:0046330 | 52 | 0.099 | |
| regulation of mitochondrial membrane permeability | GO:0046902 | 25 | 0.099 | |
| regulation of purine nucleotide metabolic process | GO:1900542 | 264 | 0.097 | |
| regulation of proteasomal ubiquitin dependent protein catabolic process | GO:0032434 | 71 | 0.096 | |
| purine nucleoside triphosphate catabolic process | GO:0009146 | 392 | 0.095 | |
| endocrine system development | GO:0035270 | 26 | 0.093 | |
| cardiovascular system development | GO:0072358 | 262 | 0.092 | |
| intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator | GO:0042771 | 23 | 0.092 | |
| regulation of protein acetylation | GO:1901983 | 25 | 0.092 | |
| regulation of defense response to virus | GO:0050688 | 33 | 0.092 | |
| regulation of neural precursor cell proliferation | GO:2000177 | 4 | 0.092 | |
| cellular response to dsrna | GO:0071359 | 19 | 0.092 | |
| developmental process involved in reproduction | GO:0003006 | 66 | 0.092 | Worm |
| sensory organ development | GO:0007423 | 52 | 0.091 | |
| forebrain development | GO:0030900 | 26 | 0.091 | |
| positive regulation of neuron death | GO:1901216 | 14 | 0.089 | |
| mrna transcription | GO:0009299 | 8 | 0.089 | |
| ribonucleoside triphosphate catabolic process | GO:0009203 | 391 | 0.089 | |
| muscle tissue development | GO:0060537 | 62 | 0.088 | |
| secretion | GO:0046903 | 254 | 0.088 | |
| nuclear import | GO:0051170 | 106 | 0.088 | Fly |
| methylation dependent chromatin silencing | GO:0006346 | 3 | 0.087 | |
| negative regulation of gliogenesis | GO:0014014 | 3 | 0.087 | |
| protein dna complex subunit organization | GO:0071824 | 80 | 0.086 | |
| regulation of cellular component biogenesis | GO:0044087 | 281 | 0.085 | |
| regulation of innate immune response | GO:0045088 | 97 | 0.085 | |
| regulation of mitochondrion organization | GO:0010821 | 54 | 0.084 | |
| fas signaling pathway | GO:0036337 | 3 | 0.084 | |
| somitogenesis | GO:0001756 | 2 | 0.084 | |
| regulation of schwann cell proliferation | GO:0010624 | 1 | 0.083 | |
| positive regulation of mammary gland involution | GO:1903521 | 1 | 0.082 | |
| positive regulation of response to dna damage stimulus | GO:2001022 | 43 | 0.082 | |
| negative regulation of dna binding | GO:0043392 | 18 | 0.082 | |
| regulation of vasculature development | GO:1901342 | 97 | 0.081 | |
| regulation of defense response | GO:0031347 | 154 | 0.081 | |
| circadian regulation of gene expression | GO:0032922 | 8 | 0.081 | |
| negative regulation of multi organism process | GO:0043901 | 92 | 0.081 | |
| positive regulation of chromatin modification | GO:1903310 | 30 | 0.080 | |
| regulation of developmental pigmentation | GO:0048070 | 2 | 0.079 | |
| positive regulation of alpha beta t cell differentiation | GO:0046638 | 4 | 0.079 | |
| negative regulation of protein deubiquitination | GO:0090086 | 3 | 0.078 | |
| cellular response to inorganic substance | GO:0071241 | 45 | 0.078 | |
| palate development | GO:0060021 | 13 | 0.078 | |
| small gtpase mediated signal transduction | GO:0007264 | 78 | 0.077 | |
| positive regulation of proteasomal ubiquitin dependent protein catabolic process | GO:0032436 | 30 | 0.076 | |
| endomembrane system organization | GO:0010256 | 196 | 0.076 | |
| microtubule based process | GO:0007017 | 210 | 0.075 | Yeast |
| camera type eye morphogenesis | GO:0048593 | 12 | 0.075 | |
| cerebellum development | GO:0021549 | 2 | 0.075 | |
| negative regulation of cytokine production | GO:0001818 | 82 | 0.075 | |
| regulation of metal ion transport | GO:0010959 | 120 | 0.075 | |
| mitochondrion organization | GO:0007005 | 156 | 0.074 | |
| atp metabolic process | GO:0046034 | 176 | 0.074 | |
| wnt signaling pathway | GO:0016055 | 156 | 0.074 | |
| regulation of ion transport | GO:0043269 | 189 | 0.074 | |
| cellular chemical homeostasis | GO:0055082 | 180 | 0.073 | |
| response to oxygen containing compound | GO:1901700 | 369 | 0.073 | |
| embryonic epithelial tube formation | GO:0001838 | 4 | 0.073 | |
| regulation of lymphocyte activation | GO:0051249 | 103 | 0.073 | |
| negative regulation of defense response | GO:0031348 | 47 | 0.072 | |
| positive regulation of cell cycle arrest | GO:0071158 | 23 | 0.072 | |
| genetic imprinting | GO:0071514 | 1 | 0.072 | |
| response to interleukin 1 | GO:0070555 | 47 | 0.072 | |
| regulation of cell motility | GO:2000145 | 299 | 0.072 | |
| endothelial cell apoptotic process | GO:0072577 | 26 | 0.071 | |
| positive regulation of nervous system development | GO:0051962 | 54 | 0.071 | |
| regulation of transmembrane transport | GO:0034762 | 139 | 0.071 | |
| mitochondrial fission | GO:0000266 | 14 | 0.070 | |
| protein homooligomerization | GO:0051260 | 100 | 0.070 | |
| cellular response to abiotic stimulus | GO:0071214 | 117 | 0.069 | |
| cellular response to parathyroid hormone stimulus | GO:0071374 | 2 | 0.069 | |
| membrane organization | GO:0061024 | 292 | 0.068 | |
| cytokine mediated signaling pathway | GO:0019221 | 109 | 0.068 | |
| forebrain neuron differentiation | GO:0021879 | 3 | 0.068 | |
| regulation of epithelial cell migration | GO:0010632 | 93 | 0.068 | |
| neuron projection development | GO:0031175 | 106 | 0.067 | |
| reproductive process | GO:0022414 | 106 | 0.067 | Worm Fly |
