IMP: Integrative Multi-species Prediction

Homo sapiens

180 known processes

UBE2N

ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)

(Aliases: MGC131857,UBC13,UbcH-ben,MGC8489)

Entrez: 7334
HGNC: 12492
HPRD: 04725
MIM: 603679
Ensembl: ENSG00000177889
UniProtKB: P61088
UniProtKB: V9HW41

Process Predictions
Disease Predictions

UBE2N biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
protein polyubiquitination	GO:0000209	110	1.000
protein ubiquitination	GO:0016567	314	1.000
protein modification by small protein conjugation	GO:0032446	342	1.000
protein k48 linked ubiquitination	GO:0070936	38	1.000
protein k63 linked ubiquitination	GO:0070534	31	1.000
ubiquitin dependent protein catabolic process	GO:0006511	206	1.000	Mouse
modification dependent macromolecule catabolic process	GO:0043632	212	0.999	Mouse
proteolysis involved in cellular protein catabolic process	GO:0051603	244	0.999	Mouse
cellular macromolecule catabolic process	GO:0044265	380	0.998
modification dependent protein catabolic process	GO:0019941	209	0.998	Mouse
cellular protein catabolic process	GO:0044257	261	0.995	Mouse
protein catabolic process	GO:0030163	325	0.987	Mouse
protein autoubiquitination	GO:0051865	37	0.961
cellular response to dna damage stimulus	GO:0006974	379	0.946
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	156	0.904
regulation of response to dna damage stimulus	GO:2001020	94	0.901
defense response	GO:0006952	315	0.834
histone ubiquitination	GO:0016574	31	0.829
positive regulation of protein modification by small protein conjugation or removal	GO:1903322	61	0.775
positive regulation of protein ubiquitination	GO:0031398	53	0.722
double strand break repair	GO:0006302	101	0.660
protein monoubiquitination	GO:0006513	39	0.631
response to radiation	GO:0009314	151	0.599
response to abiotic stimulus	GO:0009628	336	0.539
response to ionizing radiation	GO:0010212	65	0.534
regulation of protein ubiquitination	GO:0031396	95	0.527
proteasomal protein catabolic process	GO:0010498	176	0.472
regulation of proteolysis	GO:0030162	293	0.462
negative regulation of apoptotic process	GO:0043066	316	0.456
transmembrane transport	GO:0055085	399	0.451
intracellular protein transmembrane import	GO:0044743	23	0.435
dna repair	GO:0006281	198	0.386
regulation of cellular response to stress	GO:0080135	244	0.379
positive regulation of sequence specific dna binding transcription factor activity	GO:0051091	131	0.341
positive regulation of dna repair	GO:0045739	25	0.341
regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032434	71	0.320
negative regulation of cell death	GO:0060548	345	0.305
regulation of proteolysis involved in cellular protein catabolic process	GO:1903050	91	0.302
i kappab kinase nf kappab signaling	GO:0007249	166	0.280
regulation of protein catabolic process	GO:0042176	155	0.274
positive regulation of cellular component organization	GO:0051130	376	0.259
positive regulation of protein catabolic process	GO:0045732	75	0.257
cellular macromolecular complex assembly	GO:0034622	324	0.254
protein import into mitochondrial matrix	GO:0030150	1	0.236
nitrogen compound transport	GO:0071705	191	0.230
vesicle mediated transport	GO:0016192	371	0.219
regulation of cellular protein catabolic process	GO:1903362	96	0.218
positive regulation of response to dna damage stimulus	GO:2001022	43	0.218
positive regulation of dna metabolic process	GO:0051054	73	0.217
protein localization to organelle	GO:0033365	280	0.191
meiotic chromosome segregation	GO:0045132	4	0.188
post embryonic development	GO:0009791	2	0.181
immune response	GO:0006955	307	0.169
negative regulation of protein metabolic process	GO:0051248	391	0.154
protein polymerization	GO:0051258	71	0.145
chromatin modification	GO:0016568	298	0.140
regulation of defense response	GO:0031347	154	0.139
positive regulation of proteolysis	GO:0045862	142	0.130
multicellular organismal aging	GO:0010259	3	0.128
positive regulation of cell cycle	GO:0045787	140	0.110	Fly
cellular protein complex assembly	GO:0043623	188	0.102
regulation of dna repair	GO:0006282	47	0.102
carboxylic acid biosynthetic process	GO:0046394	97	0.094
protein transmembrane transport	GO:0071806	25	0.091
negative regulation of multi organism process	GO:0043901	92	0.090
endocytosis	GO:0006897	159	0.088
response to cytokine	GO:0034097	232	0.087
negative regulation of cellular protein metabolic process	GO:0032269	353	0.086
positive regulation of catabolic process	GO:0009896	310	0.085
regulation of homeostatic process	GO:0032844	121	0.085
positive regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032436	30	0.085
positive regulation of transferase activity	GO:0051347	227	0.081
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	281	0.080
determination of adult lifespan	GO:0008340	2	0.079
positive regulation of nf kappab transcription factor activity	GO:0051092	81	0.074
intracellular protein transmembrane transport	GO:0065002	24	0.072
neurogenesis	GO:0022008	169	0.071	Fly
protein ubiquitination involved in ubiquitin dependent protein catabolic process	GO:0042787	37	0.071
regulation of cell cycle process	GO:0010564	266	0.069
regulation of apoptotic signaling pathway	GO:2001233	175	0.069
single organism cellular localization	GO:1902580	332	0.068
locomotory behavior	GO:0007626	1	0.067	Fly
regulation of protein modification by small protein conjugation or removal	GO:1903320	107	0.065
mitochondrion organization	GO:0007005	156	0.064
intracellular protein transport	GO:0006886	270	0.063
regulation of ion transmembrane transport	GO:0034765	132	0.061
protein modification by small protein removal	GO:0070646	92	0.059
positive regulation of cellular component biogenesis	GO:0044089	158	0.057
protein localization to mitochondrion	GO:0070585	25	0.057
cytoplasmic transport	GO:0016482	379	0.057
nervous system development	GO:0007399	293	0.057	Fly
positive regulation of cellular catabolic process	GO:0031331	284	0.056
multi organism cellular process	GO:0044764	156	0.055
intrinsic apoptotic signaling pathway	GO:0097193	127	0.055
negative regulation of catalytic activity	GO:0043086	335	0.055
regulation of sequence specific dna binding transcription factor activity	GO:0051090	211	0.055
intrinsic apoptotic signaling pathway in response to dna damage	GO:0008630	50	0.053
establishment of protein localization to mitochondrion	GO:0072655	22	0.053
positive regulation of proteasomal protein catabolic process	GO:1901800	35	0.053
secretion by cell	GO:0032940	226	0.053
positive regulation of i kappab kinase nf kappab signaling	GO:0043123	132	0.052
regulation of ion transport	GO:0043269	189	0.050
positive regulation of developmental process	GO:0051094	314	0.049	Fly
immune system development	GO:0002520	195	0.047
negative regulation of cell cycle	GO:0045786	193	0.046
response to other organism	GO:0051707	261	0.046
chromosome segregation	GO:0007059	114	0.046
protein targeting	GO:0006605	187	0.046
negative regulation of intracellular signal transduction	GO:1902532	183	0.046
regulation of proteasomal protein catabolic process	GO:0061136	87	0.045
regulation of transmembrane transport	GO:0034762	139	0.045
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	116	0.044
negative regulation of protein processing	GO:0010955	142	0.042
rna processing	GO:0006396	255	0.041
protein targeting to mitochondrion	GO:0006626	19	0.040
immune effector process	GO:0002252	159	0.039
cell growth	GO:0016049	160	0.038
negative regulation of protein ubiquitination	GO:0031397	35	0.038
reproduction	GO:0000003	63	0.037
secretion	GO:0046903	254	0.037
negative regulation of programmed cell death	GO:0043069	321	0.036
growth	GO:0040007	202	0.034	Fly
response to biotic stimulus	GO:0009607	276	0.034
regulation of i kappab kinase nf kappab signaling	GO:0043122	162	0.033
defense response to other organism	GO:0098542	129	0.032
innate immune response	GO:0045087	178	0.031
response to organic cyclic compound	GO:0014070	204	0.031
regulation of mitotic cell cycle	GO:0007346	189	0.030	Fly
response to light stimulus	GO:0009416	87	0.030
negative regulation of cell proliferation	GO:0008285	228	0.029
er associated ubiquitin dependent protein catabolic process	GO:0030433	31	0.029
nuclear division	GO:0000280	128	0.029
regulation of symbiosis encompassing mutualism through parasitism	GO:0043903	109	0.028
negative regulation of viral process	GO:0048525	66	0.027
free ubiquitin chain polymerization	GO:0010994	2	0.027
interspecies interaction between organisms	GO:0044419	156	0.026
receptor mediated endocytosis	GO:0006898	84	0.026
organelle localization	GO:0051640	84	0.026
aging	GO:0007568	66	0.026
postreplication repair	GO:0006301	12	0.026
regulation of transferase activity	GO:0051338	355	0.025
ribonucleotide biosynthetic process	GO:0009260	81	0.024
organelle fission	GO:0048285	149	0.024
protein import	GO:0017038	130	0.024
regulation of cellular component biogenesis	GO:0044087	281	0.024
fertilization	GO:0009566	12	0.024
cell activation	GO:0001775	213	0.023
cell development	GO:0048468	328	0.023	Fly
positive regulation of cell differentiation	GO:0045597	211	0.023
establishment of protein localization to organelle	GO:0072594	172	0.023
cell morphogenesis	GO:0000902	296	0.023	Fly
nuclear migration	GO:0007097	1	0.022
covalent chromatin modification	GO:0016569	254	0.022
neuron development	GO:0048666	113	0.021	Fly
chordate embryonic development	GO:0043009	34	0.021
regulation of cell development	GO:0060284	161	0.021
negative regulation of endopeptidase activity	GO:0010951	84	0.021
enzyme linked receptor protein signaling pathway	GO:0007167	303	0.020
ncrna metabolic process	GO:0034660	108	0.020
positive regulation of nervous system development	GO:0051962	54	0.020
cell part morphogenesis	GO:0032990	137	0.020	Fly
mrna processing	GO:0006397	133	0.020
actin cytoskeleton organization	GO:0030036	207	0.020
positive regulation of neuron projection development	GO:0010976	34	0.020
adaptive immune response	GO:0002250	49	0.020
spermatid differentiation	GO:0048515	4	0.019
negative regulation of cellular component organization	GO:0051129	235	0.019
oogenesis	GO:0048477	2	0.019
maintenance of location	GO:0051235	112	0.019
small molecule biosynthetic process	GO:0044283	157	0.019
mitotic dna integrity checkpoint	GO:0044774	30	0.018
nucleic acid phosphodiester bond hydrolysis	GO:0090305	102	0.018
response to oxygen containing compound	GO:1901700	369	0.018
response to virus	GO:0009615	126	0.018
segmentation	GO:0035282	4	0.018
female gamete generation	GO:0007292	2	0.018
regulation of binding	GO:0051098	111	0.017
dna templated transcription elongation	GO:0006354	25	0.017
regulation of ubiquitin protein transferase activity	GO:0051438	28	0.017
positive regulation of locomotion	GO:0040017	186	0.017
rna catabolic process	GO:0006401	71	0.017
signal transduction by p53 class mediator	GO:0072331	72	0.016
small gtpase mediated signal transduction	GO:0007264	78	0.016
mrna metabolic process	GO:0016071	175	0.016
histone modification	GO:0016570	251	0.016
regeneration	GO:0031099	4	0.016
regulation of kinase activity	GO:0043549	314	0.016
negative regulation of immune response	GO:0050777	40	0.016
ncrna processing	GO:0034470	83	0.016
negative regulation of cell cycle process	GO:0010948	121	0.016
negative regulation of cell cycle phase transition	GO:1901988	89	0.015
regulation of cell differentiation	GO:0045595	393	0.015
negative regulation of hydrolase activity	GO:0051346	182	0.015
regulation of dna metabolic process	GO:0051052	153	0.015
spermatid development	GO:0007286	4	0.015
posttranscriptional regulation of gene expression	GO:0010608	213	0.015
detection of stimulus	GO:0051606	85	0.015	Zebrafish
nucleus localization	GO:0051647	1	0.015
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	125	0.015
lipid localization	GO:0010876	106	0.015
negative regulation of mitotic cell cycle	GO:0045930	102	0.014
regulation of cytokine production	GO:0001817	232	0.014
regulation of protein binding	GO:0043393	66	0.014
response to external biotic stimulus	GO:0043207	261	0.014
multicellular organism reproduction	GO:0032504	42	0.014
negative regulation of phosphorus metabolic process	GO:0010563	267	0.014
organic acid biosynthetic process	GO:0016053	97	0.014
tripartite regional subdivision	GO:0007351	2	0.014
negative regulation of catabolic process	GO:0009895	104	0.014
negative regulation of protein maturation	GO:1903318	142	0.014
anterior posterior axis specification	GO:0009948	2	0.014
mitotic cell cycle	GO:0000278	326	0.013	Fly
negative regulation of protein modification by small protein conjugation or removal	GO:1903321	41	0.013
rna interference	GO:0016246	4	0.013
negative regulation of proteolysis	GO:0045861	132	0.013
actin filament based process	GO:0030029	224	0.013
chromatin organization	GO:0006325	351	0.013
positive regulation of cell development	GO:0010720	92	0.013
apoptotic signaling pathway	GO:0097190	268	0.013
response to lipid	GO:0033993	206	0.013
chaperone cofactor dependent protein refolding	GO:0070389	4	0.013
oocyte differentiation	GO:0009994	2	0.012
cellular lipid metabolic process	GO:0044255	303	0.012
cellular homeostasis	GO:0019725	196	0.012
single organism reproductive process	GO:0044702	98	0.012
negative regulation of phosphorylation	GO:0042326	174	0.012
positive regulation of cellular component movement	GO:0051272	181	0.012
macromolecular complex disassembly	GO:0032984	60	0.012
mrna catabolic process	GO:0006402	56	0.012
positive regulation of apoptotic signaling pathway	GO:2001235	70	0.012
positive regulation of immune response	GO:0050778	159	0.012
negative regulation of intrinsic apoptotic signaling pathway	GO:2001243	40	0.011
regulation of protein processing	GO:0070613	150	0.011
cellular response to lipid	GO:0071396	127	0.011
establishment or maintenance of cytoskeleton polarity	GO:0030952	3	0.011
regulation of notch signaling pathway	GO:0008593	18	0.010
leukocyte mediated immunity	GO:0002443	59	0.010
negative regulation of phosphate metabolic process	GO:0045936	267	0.010
response to bacterium	GO:0009617	144	0.010
regulation of immune response	GO:0050776	201	0.010
regulation of ion transmembrane transporter activity	GO:0032412	72	0.010
negative regulation of immune system process	GO:0002683	136	0.010
regulation of neuron differentiation	GO:0045664	70	0.010

UBE2N disease predictions

Disease	DO term ID	Size	Probability
muscle tissue disease	DOID:66	113	0.020
myopathy	DOID:423	104	0.020
muscular disease	DOID:0080000	114	0.020
muscular dystrophy	DOID:9884	51	0.020
musculoskeletal system disease	DOID:17	223	0.020

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