IMP: Integrative Multi-species Prediction

Homo sapiens

11 known processes

UCHL3

ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)

(Aliases: UCH-L3)

HPRD: 04367
MIM: 603090
Entrez: 7347
Ensembl: ENSG00000118939
HGNC: 12515
UniProtKB: A0A087WTB8
UniProtKB: P15374

Process Predictions
Disease Predictions

UCHL3 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
post embryonic development	GO:0009791	2	0.784
positive regulation of catabolic process	GO:0009896	310	0.165
endocytosis	GO:0006897	159	0.146
modification dependent protein catabolic process	GO:0019941	209	0.138
ubiquitin dependent protein catabolic process	GO:0006511	206	0.135
protein catabolic process	GO:0030163	325	0.130
vesicle mediated transport	GO:0016192	371	0.129
modification dependent macromolecule catabolic process	GO:0043632	212	0.117
embryo development	GO:0009790	123	0.106
nervous system development	GO:0007399	293	0.097
cellular macromolecule catabolic process	GO:0044265	380	0.094
oogenesis	GO:0048477	2	0.089
female gamete generation	GO:0007292	2	0.083
amine metabolic process	GO:0009308	44	0.082
cell development	GO:0048468	328	0.082
regulation of protein transport	GO:0051223	213	0.076
multicellular organismal aging	GO:0010259	3	0.071
regulation of mitotic cell cycle	GO:0007346	189	0.069
cellular amine metabolic process	GO:0044106	41	0.063
protein modification by small protein removal	GO:0070646	92	0.062
purine nucleoside triphosphate metabolic process	GO:0009144	412	0.061
proteolysis involved in cellular protein catabolic process	GO:0051603	244	0.061
determination of adult lifespan	GO:0008340	2	0.060
cellular protein catabolic process	GO:0044257	261	0.059
positive regulation of cellular catabolic process	GO:0031331	284	0.056
purine ribonucleoside metabolic process	GO:0046128	437	0.055
negative regulation of programmed cell death	GO:0043069	321	0.055
cellular amino acid metabolic process	GO:0006520	116	0.054
neuron differentiation	GO:0030182	138	0.054
guanosine containing compound catabolic process	GO:1901069	239	0.053
intracellular protein transport	GO:0006886	270	0.049
posttranscriptional regulation of gene expression	GO:0010608	213	0.048
nucleic acid phosphodiester bond hydrolysis	GO:0090305	102	0.047
regulation of cell cycle phase transition	GO:1901987	126	0.046
purine nucleoside catabolic process	GO:0006152	398	0.044
cellular response to dna damage stimulus	GO:0006974	379	0.042
positive regulation of programmed cell death	GO:0043068	249	0.042
guanosine containing compound metabolic process	GO:1901068	244	0.042
protein localization to organelle	GO:0033365	280	0.042
cell cycle checkpoint	GO:0000075	117	0.041
regulation of cell cycle	GO:0051726	393	0.041
dna damage response signal transduction by p53 class mediator	GO:0030330	44	0.041
receptor mediated endocytosis	GO:0006898	84	0.040
positive regulation of proteolysis	GO:0045862	142	0.040
regulation of protein catabolic process	GO:0042176	155	0.040
negative regulation of cell death	GO:0060548	345	0.040
mitotic cell cycle	GO:0000278	326	0.038
negative regulation of apoptotic process	GO:0043066	316	0.038
cytokine production	GO:0001816	247	0.037
neurogenesis	GO:0022008	169	0.036
actin filament based process	GO:0030029	224	0.035
positive regulation of cell proliferation	GO:0008284	301	0.035
epithelium development	GO:0060429	227	0.035
regulation of cellular response to stress	GO:0080135	244	0.035
innate immune response	GO:0045087	178	0.035
apoptotic mitochondrial changes	GO:0008637	57	0.034
regulation of protein stability	GO:0031647	87	0.033
system process	GO:0003008	349	0.033
purine containing compound catabolic process	GO:0072523	411	0.031
nucleoside triphosphate metabolic process	GO:0009141	422	0.031
gtp metabolic process	GO:0046039	239	0.031
positive regulation of hydrolase activity	GO:0051345	331	0.031
single organism cellular localization	GO:1902580	332	0.031
mitotic cell cycle phase transition	GO:0044772	162	0.030
organophosphate catabolic process	GO:0046434	430	0.030
establishment of protein localization to organelle	GO:0072594	172	0.029
purine nucleoside triphosphate catabolic process	GO:0009146	392	0.029
positive regulation of protein catabolic process	GO:0045732	75	0.029
nucleotide catabolic process	GO:0009166	408	0.029
neural crest cell development	GO:0014032	3	0.028
purine nucleotide catabolic process	GO:0006195	405	0.028
response to abiotic stimulus	GO:0009628	336	0.028
apoptotic signaling pathway	GO:0097190	268	0.028
metal ion homeostasis	GO:0055065	169	0.027
positive regulation of purine nucleotide catabolic process	GO:0033123	185	0.027
protein modification by small protein conjugation	GO:0032446	342	0.027
regulation of proteolysis	GO:0030162	293	0.027
purine containing compound salvage	GO:0043101	2	0.027
positive regulation of purine nucleotide metabolic process	GO:1900544	227	0.026
generation of neurons	GO:0048699	152	0.026
negative regulation of protein metabolic process	GO:0051248	391	0.026
negative regulation of mitotic cell cycle phase transition	GO:1901991	85	0.026
nucleoside phosphate catabolic process	GO:1901292	412	0.026
protein k63 linked deubiquitination	GO:0070536	21	0.026
reproduction	GO:0000003	63	0.025
negative regulation of cell cycle phase transition	GO:1901988	89	0.025
regulation of proteasomal protein catabolic process	GO:0061136	87	0.025
oocyte differentiation	GO:0009994	2	0.025
positive regulation of transport	GO:0051050	336	0.025
gtp catabolic process	GO:0006184	237	0.025
ribonucleoside triphosphate metabolic process	GO:0009199	412	0.025
regulation of protein import into nucleus	GO:0042306	78	0.025
purine nucleotide biosynthetic process	GO:0006164	84	0.025
organelle fission	GO:0048285	149	0.024
chemical homeostasis	GO:0048878	306	0.024
organophosphate biosynthetic process	GO:0090407	163	0.024
protein import	GO:0017038	130	0.023
regulation of cytoplasmic transport	GO:1903649	149	0.023
regulation of establishment of protein localization	GO:0070201	242	0.023
cell division	GO:0051301	168	0.023
protein targeting	GO:0006605	187	0.023
protein deubiquitination	GO:0016579	79	0.022
regulation of protein targeting	GO:1903533	91	0.022
regulation of response to dna damage stimulus	GO:2001020	94	0.022
regulation of intracellular protein transport	GO:0033157	123	0.022
response to other organism	GO:0051707	261	0.022
oxidation reduction process	GO:0055114	396	0.022
immune response	GO:0006955	307	0.022
regulation of mitotic cell cycle phase transition	GO:1901990	118	0.022
ribonucleoside triphosphate catabolic process	GO:0009203	391	0.022
mitotic cell cycle process	GO:1903047	286	0.022
mitochondrial transport	GO:0006839	60	0.022
rna interference	GO:0016246	4	0.022
purine ribonucleoside catabolic process	GO:0046130	398	0.021
glycosyl compound catabolic process	GO:1901658	413	0.021
secretion by cell	GO:0032940	226	0.021
protein import into mitochondrial matrix	GO:0030150	1	0.021
calcium ion transport	GO:0006816	147	0.021
cell type specific apoptotic process	GO:0097285	125	0.021
positive regulation of cell death	GO:0010942	263	0.021
segmentation	GO:0035282	4	0.021
cellular ketone metabolic process	GO:0042180	80	0.020
positive regulation of protein transport	GO:0051222	135	0.020
positive regulation of cellular component organization	GO:0051130	376	0.020
transmembrane transport	GO:0055085	399	0.020
central nervous system development	GO:0007417	123	0.020
ncrna metabolic process	GO:0034660	108	0.020
histone modification	GO:0016570	251	0.020
embryo development ending in birth or egg hatching	GO:0009792	34	0.019
nuclear import	GO:0051170	106	0.019
cell projection organization	GO:0030030	252	0.019
secretion	GO:0046903	254	0.019
positive regulation of phosphorylation	GO:0042327	394	0.019
reactive oxygen species metabolic process	GO:0072593	75	0.019
regulation of cell cycle process	GO:0010564	266	0.019
cytoplasmic transport	GO:0016482	379	0.018
positive regulation of proteasomal protein catabolic process	GO:1901800	35	0.018
negative regulation of mitotic cell cycle	GO:0045930	102	0.018
positive regulation of developmental process	GO:0051094	314	0.018
negative regulation of cell cycle	GO:0045786	193	0.018
protein maturation	GO:0051604	233	0.018
membrane organization	GO:0061024	292	0.018
cellular chemical homeostasis	GO:0055082	180	0.018
lipid biosynthetic process	GO:0008610	177	0.018
regulation of transferase activity	GO:0051338	355	0.018
mitotic cell cycle checkpoint	GO:0007093	68	0.017
single organism nuclear import	GO:1902593	104	0.017
dna integrity checkpoint	GO:0031570	71	0.017
cellular component morphogenesis	GO:0032989	314	0.017
reproductive process	GO:0022414	106	0.017
regulation of intracellular transport	GO:0032386	195	0.017
cell cycle phase transition	GO:0044770	173	0.017
organelle assembly	GO:0070925	176	0.017
cranial nerve development	GO:0021545	4	0.017
negative regulation of catabolic process	GO:0009895	104	0.017
nucleoside catabolic process	GO:0009164	408	0.017
nucleoside phosphate biosynthetic process	GO:1901293	109	0.016
ribonucleotide biosynthetic process	GO:0009260	81	0.016
aging	GO:0007568	66	0.016
regulation of kinase activity	GO:0043549	314	0.016
regulation of cellular amine metabolic process	GO:0033238	11	0.016
protein ubiquitination	GO:0016567	314	0.016
regulation of cellular ketone metabolic process	GO:0010565	50	0.016
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	156	0.016
nucleoside triphosphate catabolic process	GO:0009143	394	0.016
purine ribonucleoside triphosphate metabolic process	GO:0009205	411	0.016
microtubule based process	GO:0007017	210	0.016
positive regulation of immune system process	GO:0002684	283	0.016
regulation of protein localization	GO:0032880	296	0.016
regulation of cell development	GO:0060284	161	0.016
response to biotic stimulus	GO:0009607	276	0.016
signal transduction in response to dna damage	GO:0042770	57	0.016
epithelial cell differentiation	GO:0030855	141	0.015
heart process	GO:0003015	62	0.015
maturation of 5 8s rrna	GO:0000460	8	0.015
mitotic nuclear division	GO:0007067	119	0.015
ribonucleotide catabolic process	GO:0009261	405	0.015
photoreceptor cell differentiation	GO:0046530	2	0.015
protein targeting to nucleus	GO:0044744	104	0.014
divalent inorganic cation transport	GO:0072511	158	0.014
positive regulation of nucleotide catabolic process	GO:0030813	185	0.014
cellular lipid metabolic process	GO:0044255	303	0.014
sex differentiation	GO:0007548	45	0.014
maturation of 5 8s rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna	GO:0000466	2	0.014
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	281	0.014
protein import into nucleus	GO:0006606	104	0.014
regulation of apoptotic signaling pathway	GO:2001233	175	0.014
purine containing compound biosynthetic process	GO:0072522	88	0.014
regulation of mitosis	GO:0007088	63	0.014
regulation of cellular component biogenesis	GO:0044087	281	0.013
reproductive system development	GO:0061458	56	0.013
response to external biotic stimulus	GO:0043207	261	0.013
positive regulation of cellular amine metabolic process	GO:0033240	7	0.013
single organism membrane organization	GO:0044802	268	0.013
regulation of cellular protein catabolic process	GO:1903362	96	0.013
spermatid differentiation	GO:0048515	4	0.013
single organism reproductive process	GO:0044702	98	0.013
immune effector process	GO:0002252	159	0.013
positive regulation of cellular protein catabolic process	GO:1903364	37	0.013
gene silencing	GO:0016458	49	0.013
cellular ion homeostasis	GO:0006873	168	0.013
protein stabilization	GO:0050821	64	0.013
purine ribonucleotide catabolic process	GO:0009154	404	0.012
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.012
regulation of nucleocytoplasmic transport	GO:0046822	98	0.012
regulation of cellular amino acid metabolic process	GO:0006521	6	0.012
positive regulation of apoptotic process	GO:0043065	246	0.012
cellular homeostasis	GO:0019725	196	0.012
positive regulation of peptidase activity	GO:0010952	88	0.012
negative regulation of intracellular signal transduction	GO:1902532	183	0.012
blastoderm segmentation	GO:0007350	2	0.012
cellular metal ion homeostasis	GO:0006875	146	0.012
negative regulation of cellular protein metabolic process	GO:0032269	353	0.012
activation of immune response	GO:0002253	114	0.012
metal ion transport	GO:0030001	272	0.012
positive regulation of cytoplasmic transport	GO:1903651	82	0.012
muscle system process	GO:0003012	81	0.012
trna splicing via endonucleolytic cleavage and ligation	GO:0006388	7	0.012
negative regulation of multicellular organismal process	GO:0051241	317	0.012
cellular calcium ion homeostasis	GO:0006874	117	0.012
multicellular organism reproduction	GO:0032504	42	0.011
hematopoietic or lymphoid organ development	GO:0048534	186	0.011
divalent metal ion transport	GO:0070838	152	0.011
regulation of cytokine production	GO:0001817	232	0.011
developmental process involved in reproduction	GO:0003006	66	0.011
positive regulation of proteolysis involved in cellular protein catabolic process	GO:1903052	35	0.011
organonitrogen compound biosynthetic process	GO:1901566	200	0.011
growth	GO:0040007	202	0.011
cellular response to endogenous stimulus	GO:0071495	336	0.011
peroxisome organization	GO:0007031	28	0.011
cytokine secretion	GO:0050663	64	0.011
positive regulation of protein phosphorylation	GO:0001934	313	0.011
glial cell migration	GO:0008347	4	0.011
cation homeostasis	GO:0055080	189	0.011
proteasomal protein catabolic process	GO:0010498	176	0.011
optic nerve development	GO:0021554	2	0.011
nuclear transport	GO:0051169	179	0.011
protein localization to nucleus	GO:0034504	136	0.011
microtubule cytoskeleton organization	GO:0000226	176	0.011
double strand break repair	GO:0006302	101	0.010
positive regulation of cell differentiation	GO:0045597	211	0.010
ribonucleoprotein complex biogenesis	GO:0022613	116	0.010
nucleocytoplasmic transport	GO:0006913	176	0.010
regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032434	71	0.010

UCHL3 disease predictions

Disease	DO term ID	Size	Probability
inherited metabolic disorder	DOID:655	242	0.131
disease of metabolism	DOID:0014667	295	0.131
amino acid metabolic disorder	DOID:9252	50	0.038
immune system disease	DOID:2914	155	0.017
disease of mental health	DOID:150	70	0.012
developmental disorder of mental health	DOID:0060037	29	0.012

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