IMP: Integrative Multi-species Prediction

Homo sapiens

76 known processes

USP7

ubiquitin specific peptidase 7 (herpes virus-associated)

(Aliases: TEF1,HAUSP)

Ensembl: ENSG00000187555
HGNC: 12630
Entrez: 7874
MIM: 602519
HPRD: 03950
UniProtKB: Q6U8A4
UniProtKB: B7ZAX6
UniProtKB: B7Z855
UniProtKB: Q93009

Process Predictions
Disease Predictions

USP7 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
protein ubiquitination	GO:0016567	314	1.000
protein modification by small protein conjugation	GO:0032446	342	1.000
histone h2a ubiquitination	GO:0033522	17	1.000
chromatin organization	GO:0006325	351	1.000	Fly
histone ubiquitination	GO:0016574	31	1.000
histone monoubiquitination	GO:0010390	20	1.000
chromatin modification	GO:0016568	298	1.000	Fly
histone h2a monoubiquitination	GO:0035518	11	0.998
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	281	0.998
histone modification	GO:0016570	251	0.995	Fly
modification dependent protein catabolic process	GO:0019941	209	0.995
protein monoubiquitination	GO:0006513	39	0.994
apoptotic signaling pathway	GO:0097190	268	0.993
proteolysis involved in cellular protein catabolic process	GO:0051603	244	0.993
segmentation	GO:0035282	4	0.983
modification dependent macromolecule catabolic process	GO:0043632	212	0.978
regulation of intrinsic apoptotic signaling pathway	GO:2001242	72	0.976
protein catabolic process	GO:0030163	325	0.976
cellular protein catabolic process	GO:0044257	261	0.968
ubiquitin dependent protein catabolic process	GO:0006511	206	0.964
cellular macromolecule catabolic process	GO:0044265	380	0.963
regulation of protein ubiquitination	GO:0031396	95	0.959
covalent chromatin modification	GO:0016569	254	0.951	Fly
negative regulation of cell death	GO:0060548	345	0.941
negative regulation of apoptotic signaling pathway	GO:2001234	97	0.935
intrinsic apoptotic signaling pathway	GO:0097193	127	0.918
response to abiotic stimulus	GO:0009628	336	0.909
response to radiation	GO:0009314	151	0.896
fibroblast proliferation	GO:0048144	33	0.895
blastoderm segmentation	GO:0007350	2	0.892
gene silencing	GO:0016458	49	0.888	Fly
mrna metabolic process	GO:0016071	175	0.881
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	156	0.877
response to endoplasmic reticulum stress	GO:0034976	49	0.867
rostrocaudal neural tube patterning	GO:0021903	1	0.851
regulation of chromosome organization	GO:0033044	103	0.844
regulation of protein modification by small protein conjugation or removal	GO:1903320	107	0.836
negative regulation of cellular protein metabolic process	GO:0032269	353	0.821
regulation of apoptotic signaling pathway	GO:2001233	175	0.816
negative regulation of intrinsic apoptotic signaling pathway	GO:2001243	40	0.791
dna repair	GO:0006281	198	0.779
embryo development	GO:0009790	123	0.773	Worm
cell development	GO:0048468	328	0.768
posttranscriptional regulation of gene expression	GO:0010608	213	0.768	Rat
transforming growth factor beta receptor signaling pathway	GO:0007179	76	0.759
cellular response to dna damage stimulus	GO:0006974	379	0.758
negative regulation of protein metabolic process	GO:0051248	391	0.754
mitotic cell cycle	GO:0000278	326	0.747
negative regulation of chromosome organization	GO:2001251	48	0.731
negative regulation of g1 s transition of mitotic cell cycle	GO:2000134	29	0.728
protein ubiquitination involved in ubiquitin dependent protein catabolic process	GO:0042787	37	0.727
response to gamma radiation	GO:0010332	14	0.703
anterior posterior axis specification	GO:0009948	2	0.696
regulation of proteolysis involved in cellular protein catabolic process	GO:1903050	91	0.660
bmp signaling pathway	GO:0030509	49	0.644
negative regulation of programmed cell death	GO:0043069	321	0.633
regulation of transferase activity	GO:0051338	355	0.609
negative regulation of apoptotic process	GO:0043066	316	0.592
regulation of nervous system development	GO:0051960	88	0.591
internal peptidyl lysine acetylation	GO:0018393	97	0.589
macromolecule methylation	GO:0043414	97	0.576
response to oxygen containing compound	GO:1901700	369	0.564
positive regulation of cell proliferation	GO:0008284	301	0.555
positive regulation of transferase activity	GO:0051347	227	0.552
negative regulation of protein modification process	GO:0031400	200	0.548
protein deubiquitination	GO:0016579	79	0.545
regulation of cell cycle	GO:0051726	393	0.541
positive regulation of protein modification by small protein conjugation or removal	GO:1903322	61	0.527
chemotaxis	GO:0006935	157	0.514
cellular response to growth factor stimulus	GO:0071363	197	0.505
proteasomal protein catabolic process	GO:0010498	176	0.490
regulation of response to dna damage stimulus	GO:2001020	94	0.475
regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032434	71	0.474
rna processing	GO:0006396	255	0.467
regulation of cellular response to stress	GO:0080135	244	0.461
response to ionizing radiation	GO:0010212	65	0.436
pattern specification process	GO:0007389	43	0.403
regulation of cell cycle process	GO:0010564	266	0.400
protein localization to organelle	GO:0033365	280	0.400
intracellular receptor signaling pathway	GO:0030522	104	0.399
response to growth factor	GO:0070848	205	0.395
positive regulation of ligase activity	GO:0051351	19	0.390
cellular response to decreased oxygen levels	GO:0036294	51	0.389
mrna splicing via spliceosome	GO:0000398	89	0.388
signal transduction by p53 class mediator	GO:0072331	72	0.384
organelle fission	GO:0048285	149	0.382
cell cycle phase transition	GO:0044770	173	0.373
regulation of protein stability	GO:0031647	87	0.371	Rat
regionalization	GO:0003002	29	0.361
intrinsic apoptotic signaling pathway by p53 class mediator	GO:0072332	37	0.360
rna splicing via transesterification reactions with bulged adenosine as nucleophile	GO:0000377	89	0.358
tube development	GO:0035295	125	0.356
rna splicing via transesterification reactions	GO:0000375	90	0.349
organ morphogenesis	GO:0009887	147	0.334
protein localization to nucleus	GO:0034504	136	0.314
axonogenesis	GO:0007409	31	0.297
oocyte differentiation	GO:0009994	2	0.295
neurogenesis	GO:0022008	169	0.293
chromosome segregation	GO:0007059	114	0.290
cellular amino acid metabolic process	GO:0006520	116	0.274
cellular response to oxygen levels	GO:0071453	55	0.271
post embryonic development	GO:0009791	2	0.261	Worm
neuron projection development	GO:0031175	106	0.258
generation of neurons	GO:0048699	152	0.257
cellular response to hypoxia	GO:0071456	51	0.254
response to decreased oxygen levels	GO:0036293	96	0.245
internal protein amino acid acetylation	GO:0006475	101	0.244
cellular response to transforming growth factor beta stimulus	GO:0071560	94	0.240
growth	GO:0040007	202	0.238	Worm
positive regulation of protein ubiquitination	GO:0031398	53	0.237
negative regulation of proteolysis	GO:0045861	132	0.232
regulation of proteasomal protein catabolic process	GO:0061136	87	0.224
regulation of cell cycle arrest	GO:0071156	36	0.222
nervous system development	GO:0007399	293	0.222
response to caffeine	GO:0031000	3	0.221
protein alkylation	GO:0008213	74	0.215
establishment of protein localization to organelle	GO:0072594	172	0.214
protein targeting	GO:0006605	187	0.208
intracellular protein transport	GO:0006886	270	0.205
negative regulation of cellular component organization	GO:0051129	235	0.204
skeletal system development	GO:0001501	79	0.204
protein acylation	GO:0043543	138	0.204
taxis	GO:0042330	157	0.197
response to lipid	GO:0033993	206	0.194
female gamete generation	GO:0007292	2	0.192
spinal cord development	GO:0021510	4	0.191
neural tube patterning	GO:0021532	2	0.189
nuclear transport	GO:0051169	179	0.189
regulation of leukocyte proliferation	GO:0070663	67	0.187
positive regulation of proteasomal protein catabolic process	GO:1901800	35	0.185
negative regulation of sequence specific dna binding transcription factor activity	GO:0043433	89	0.185
neuron development	GO:0048666	113	0.180
regulation of histone modification	GO:0031056	47	0.174
negative regulation of response to dna damage stimulus	GO:2001021	33	0.174
regulation of protein catabolic process	GO:0042176	155	0.173
response to organonitrogen compound	GO:0010243	156	0.172
dna damage checkpoint	GO:0000077	68	0.168
cellular macromolecular complex assembly	GO:0034622	324	0.168
embryonic organ morphogenesis	GO:0048562	24	0.165
single organism nuclear import	GO:1902593	104	0.164
rna splicing	GO:0008380	131	0.163
regulation of cellular ketone metabolic process	GO:0010565	50	0.163
response to transforming growth factor beta	GO:0071559	94	0.161
methylation	GO:0032259	106	0.160
response to organic cyclic compound	GO:0014070	204	0.158
developmental process involved in reproduction	GO:0003006	66	0.158
negative regulation of cell cycle	GO:0045786	193	0.157
cellular response to unfolded protein	GO:0034620	16	0.157
response to nitrogen compound	GO:1901698	184	0.152
positive regulation of ubiquitin protein transferase activity	GO:0051443	18	0.151
mrna processing	GO:0006397	133	0.151
neuron differentiation	GO:0030182	138	0.151
cartilage development	GO:0051216	31	0.148
regulation of organ morphogenesis	GO:2000027	24	0.147
regulation of signal transduction by p53 class mediator	GO:1901796	26	0.147
regulation of neuron differentiation	GO:0045664	70	0.146
regulation of protein maturation	GO:1903317	150	0.145
regulation of fibroblast proliferation	GO:0048145	32	0.143
multicellular organismal aging	GO:0010259	3	0.142
histone methylation	GO:0016571	60	0.141
response to oxygen levels	GO:0070482	100	0.139
leukocyte proliferation	GO:0070661	74	0.135
response to hypoxia	GO:0001666	96	0.135
regulation of protein targeting	GO:1903533	91	0.134
negative regulation of protein ubiquitination	GO:0031397	35	0.134
locomotory behavior	GO:0007626	1	0.132
regulation of cell cycle phase transition	GO:1901987	126	0.129
chromatin silencing	GO:0006342	12	0.128	Fly
metencephalon development	GO:0022037	2	0.127
cerebellum development	GO:0021549	2	0.125
cellular response to oxidative stress	GO:0034599	85	0.125
microtubule cytoskeleton organization	GO:0000226	176	0.125
regulation of cytoplasmic transport	GO:1903649	149	0.124
ribonucleoprotein complex subunit organization	GO:0071826	81	0.123
regulation of dna metabolic process	GO:0051052	153	0.121
regulation of sequence specific dna binding transcription factor activity	GO:0051090	211	0.121
regulation of ligase activity	GO:0051340	29	0.120
negative regulation of cell cycle g1 s phase transition	GO:1902807	29	0.118
regulation of cellular protein catabolic process	GO:1903362	96	0.116
negative regulation of organelle organization	GO:0010639	126	0.115
protein import	GO:0017038	130	0.115
embryonic morphogenesis	GO:0048598	85	0.114
forebrain development	GO:0030900	26	0.113
cell cycle checkpoint	GO:0000075	117	0.111
mitotic cell cycle phase transition	GO:0044772	162	0.111
chemical homeostasis	GO:0048878	306	0.110
response to topologically incorrect protein	GO:0035966	29	0.108
regulation of b cell activation	GO:0050864	24	0.107
regulation of cell cycle g1 s phase transition	GO:1902806	42	0.106
regeneration	GO:0031099	4	0.106
negative regulation of protein processing	GO:0010955	142	0.106
signal transduction involved in mitotic cell cycle checkpoint	GO:0072413	13	0.106
limbic system development	GO:0021761	3	0.105
g1 dna damage checkpoint	GO:0044783	18	0.101
axon guidance	GO:0007411	12	0.101
negative regulation of histone modification	GO:0031057	19	0.100
regulation of protein ubiquitination involved in ubiquitin dependent protein catabolic process	GO:2000058	7	0.100
energy homeostasis	GO:0097009	3	0.098
peptidyl lysine acetylation	GO:0018394	101	0.098
eye morphogenesis	GO:0048592	16	0.097
negative regulation of mitotic cell cycle	GO:0045930	102	0.097
negative regulation of dna metabolic process	GO:0051053	57	0.097
negative regulation of chromatin modification	GO:1903309	21	0.096
response to drug	GO:0042493	81	0.096
response to oxidative stress	GO:0006979	121	0.096
negative regulation of transcription involved in g1 s transition of mitotic cell cycle	GO:0071930	2	0.096
mitotic cell cycle checkpoint	GO:0007093	68	0.095
cell growth	GO:0016049	160	0.094
mitotic g1 s transition checkpoint	GO:0044819	17	0.093
single organism cellular localization	GO:1902580	332	0.092
positive regulation of phosphorylation	GO:0042327	394	0.092
response to unfolded protein	GO:0006986	24	0.089
regulation of nucleocytoplasmic transport	GO:0046822	98	0.088
positive regulation of sequence specific dna binding transcription factor activity	GO:0051091	131	0.088
ribonucleoside monophosphate metabolic process	GO:0009161	187	0.088
protein polyubiquitination	GO:0000209	110	0.087
protein oligomerization	GO:0051259	173	0.087
regulation of translation	GO:0006417	89	0.087
heart development	GO:0007507	95	0.087
regulation of mitotic metaphase anaphase transition	GO:0030071	26	0.086
regulation of cellular amine metabolic process	GO:0033238	11	0.085
cell division	GO:0051301	168	0.085
response to alcohol	GO:0097305	64	0.083
regulation of symbiosis encompassing mutualism through parasitism	GO:0043903	109	0.083
er associated ubiquitin dependent protein catabolic process	GO:0030433	31	0.083
regulation of g1 s transition of mitotic cell cycle	GO:2000045	40	0.082
positive regulation of apoptotic signaling pathway	GO:2001235	70	0.082
chondrocyte development	GO:0002063	1	0.082
protein stabilization	GO:0050821	64	0.081
histone acetylation	GO:0016573	93	0.081
cellular response to topologically incorrect protein	GO:0035967	19	0.079
regulation of proteolysis	GO:0030162	293	0.079
regulation of cytoskeleton organization	GO:0051493	177	0.078
negative regulation of mitotic cell cycle phase transition	GO:1901991	85	0.077
establishment or maintenance of monopolar cell polarity	GO:0061339	1	0.077
regulation of mononuclear cell proliferation	GO:0032944	65	0.075
negative regulation of cell cycle phase transition	GO:1901988	89	0.074
developmental cell growth	GO:0048588	18	0.071
peptidyl lysine modification	GO:0018205	144	0.071
neuron projection morphogenesis	GO:0048812	50	0.071
signal transduction involved in dna damage checkpoint	GO:0072422	15	0.071
regulation of chromatin modification	GO:1903308	51	0.070
negative regulation of protein maturation	GO:1903318	142	0.070
positive regulation of cell cycle arrest	GO:0071158	23	0.070
response to acid chemical	GO:0001101	66	0.070
negative regulation of translation	GO:0017148	37	0.069
metal ion transport	GO:0030001	272	0.067
protein k63 linked ubiquitination	GO:0070534	31	0.066
negative regulation of protein catabolic process	GO:0042177	59	0.066
negative regulation of signal transduction by p53 class mediator	GO:1901797	15	0.066
urogenital system development	GO:0001655	65	0.065
autophagy	GO:0006914	88	0.064
dna replication	GO:0006260	116	0.063
regulation of axon guidance	GO:1902667	3	0.062
response to temperature stimulus	GO:0009266	22	0.062
hematopoietic or lymphoid organ development	GO:0048534	186	0.062
response to retinoic acid	GO:0032526	33	0.062
maintenance of location	GO:0051235	112	0.061
protein processing	GO:0016485	226	0.061
regulation of ubiquitin protein transferase activity	GO:0051438	28	0.060
ribonucleoprotein complex biogenesis	GO:0022613	116	0.060
regulation of mitotic cell cycle	GO:0007346	189	0.060
axis specification	GO:0009798	12	0.060
oocyte development	GO:0048599	1	0.060
cell morphogenesis involved in differentiation	GO:0000904	144	0.059
protein targeting to nucleus	GO:0044744	104	0.059
negative regulation of proteolysis involved in cellular protein catabolic process	GO:1903051	35	0.059
positive regulation of cellular protein catabolic process	GO:1903364	37	0.059
regulation of chromatin organization	GO:1902275	56	0.058
regulation of cell differentiation	GO:0045595	393	0.058
response to inorganic substance	GO:0010035	127	0.058
response to wounding	GO:0009611	168	0.058
immune response	GO:0006955	307	0.058
cation transport	GO:0006812	331	0.057
viral process	GO:0016032	146	0.057
positive regulation of proteolysis	GO:0045862	142	0.057
mitotic dna damage checkpoint	GO:0044773	28	0.056
mitochondrion organization	GO:0007005	156	0.056
g1 s transition of mitotic cell cycle	GO:0000082	78	0.055
cellular homeostasis	GO:0019725	196	0.055
ion homeostasis	GO:0050801	230	0.055
axon development	GO:0061564	34	0.055
response to estrogen	GO:0043627	47	0.055
regulation of protein processing	GO:0070613	150	0.054
regulation of cell development	GO:0060284	161	0.054
negative regulation of peptidase activity	GO:0010466	91	0.053
reproductive process	GO:0022414	106	0.053
regulation of viral process	GO:0050792	103	0.053
neuromuscular junction development	GO:0007528	3	0.052
g0 to g1 transition	GO:0045023	3	0.052
primary neural tube formation	GO:0014020	3	0.052
adult locomotory behavior	GO:0008344	1	0.052
zymogen activation	GO:0031638	70	0.051
negative regulation of hydrolase activity	GO:0051346	182	0.051
response to toxic substance	GO:0009636	37	0.051
positive regulation of intracellular protein transport	GO:0090316	76	0.050
transcription factor import into nucleus	GO:0042991	40	0.050
negative regulation of endopeptidase activity	GO:0010951	84	0.049
negative regulation of calcium ion import	GO:0090281	1	0.049
protein n linked glycosylation via asparagine	GO:0018279	10	0.048
positive regulation of protein complex assembly	GO:0031334	86	0.048
establishment of monopolar cell polarity	GO:0061162	1	0.048
regulation of mrna stability	GO:0043488	23	0.048
regulation of leukocyte activation	GO:0002694	115	0.048
ribosome biogenesis	GO:0042254	48	0.047
regulation of wnt signaling pathway	GO:0030111	123	0.047
negative regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043154	46	0.046
positive regulation of mitotic cell cycle	GO:0045931	60	0.046
sex differentiation	GO:0007548	45	0.046
regulation of alternative mrna splicing via spliceosome	GO:0000381	22	0.046
negative regulation of intracellular signal transduction	GO:1902532	183	0.046
regulation of nuclear division	GO:0051783	65	0.045
golgi vesicle transport	GO:0048193	80	0.045
hormone metabolic process	GO:0042445	61	0.045
negative regulation of catalytic activity	GO:0043086	335	0.045
endoplasmic reticulum unfolded protein response	GO:0030968	16	0.045
development of primary sexual characteristics	GO:0045137	35	0.044
multicellular organismal homeostasis	GO:0048871	67	0.044
modification by host of symbiont morphology or physiology	GO:0051851	26	0.043
mating	GO:0007618	1	0.043
protein modification by small protein removal	GO:0070646	92	0.042
negative regulation of viral process	GO:0048525	66	0.042
activation of immune response	GO:0002253	114	0.042
protein methylation	GO:0006479	74	0.042
regulation of tooth mineralization	GO:0070170	3	0.042
histone h3 acetylation	GO:0043966	45	0.041
regulation of transcription factor import into nucleus	GO:0042990	39	0.041
positive regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032436	30	0.041
hindbrain development	GO:0030902	3	0.041
double strand break repair	GO:0006302	101	0.040
negative regulation of catabolic process	GO:0009895	104	0.040
cellular component morphogenesis	GO:0032989	314	0.038
regulation of odontogenesis	GO:0042481	4	0.038
protein import into nucleus	GO:0006606	104	0.038
mitotic g1 dna damage checkpoint	GO:0031571	17	0.038
regulation of multi organism process	GO:0043900	157	0.037
oogenesis	GO:0048477	2	0.037
regulation of metaphase anaphase transition of cell cycle	GO:1902099	26	0.037
cell morphogenesis involved in neuron differentiation	GO:0048667	44	0.037
embryonic cranial skeleton morphogenesis	GO:0048701	6	0.037
negative regulation of protein modification by small protein conjugation or removal	GO:1903321	41	0.036
regulation of actin cytoskeleton organization	GO:0032956	116	0.036
positive regulation of cellular catabolic process	GO:0031331	284	0.036
multi organism reproductive process	GO:0044703	54	0.036
developmental programmed cell death	GO:0010623	3	0.036
response to fungus	GO:0009620	4	0.035
gland development	GO:0048732	48	0.035
vesicle mediated transport	GO:0016192	371	0.035
positive regulation of protein import into nucleus	GO:0042307	46	0.034
maintenance of protein location	GO:0045185	57	0.034
biomineral tissue development	GO:0031214	39	0.034
regulation of dna repair	GO:0006282	47	0.033
ribonucleoprotein complex assembly	GO:0022618	78	0.033
smad protein import into nucleus	GO:0007184	13	0.033
carbohydrate derivative biosynthetic process	GO:1901137	207	0.033
dna integrity checkpoint	GO:0031570	71	0.032
negative regulation of cysteine type endopeptidase activity	GO:2000117	48	0.032
monovalent inorganic cation transport	GO:0015672	128	0.032
cell projection morphogenesis	GO:0048858	129	0.032
regulation of mrna splicing via spliceosome	GO:0048024	32	0.032
behavior	GO:0007610	112	0.032
lymphocyte proliferation	GO:0046651	70	0.032
negative regulation of nf kappab transcription factor activity	GO:0032088	51	0.031
glycoprotein biosynthetic process	GO:0009101	91	0.031
cellular ketone metabolic process	GO:0042180	80	0.031
protein k48 linked ubiquitination	GO:0070936	38	0.030
sensory organ morphogenesis	GO:0090596	21	0.030
developmental maturation	GO:0021700	28	0.030
interspecies interaction between organisms	GO:0044419	156	0.030
camera type eye development	GO:0043010	25	0.029
er nucleus signaling pathway	GO:0006984	23	0.029
signal transduction involved in mitotic dna integrity checkpoint	GO:1902403	13	0.028
cell cycle arrest	GO:0007050	71	0.028
negative regulation of viral release from host cell	GO:1902187	12	0.028
regulation of rna splicing	GO:0043484	62	0.028
meiotic nuclear division	GO:0007126	10	0.027
mrna stabilization	GO:0048255	18	0.027
central nervous system development	GO:0007417	123	0.027
regulation of rna stability	GO:0043487	23	0.026
nucleoside monophosphate metabolic process	GO:0009123	191	0.026
regulation of double strand break repair	GO:2000779	22	0.026
embryonic eye morphogenesis	GO:0048048	2	0.026
establishment or maintenance of bipolar cell polarity	GO:0061245	2	0.026
chondrocyte differentiation	GO:0002062	17	0.026
embryonic camera type eye morphogenesis	GO:0048596	2	0.026
cellular modified amino acid metabolic process	GO:0006575	64	0.026
proteasomal ubiquitin independent protein catabolic process	GO:0010499	3	0.026
symbiosis encompassing mutualism through parasitism	GO:0044403	156	0.026
negative regulation of cell proliferation	GO:0008285	228	0.025
protein glycosylation	GO:0006486	62	0.025
notch signaling pathway	GO:0007219	31	0.025
wound healing	GO:0042060	115	0.025
regulation of lymphocyte proliferation	GO:0050670	64	0.025
negative regulation of protein kinase activity	GO:0006469	98	0.024
glycoprotein metabolic process	GO:0009100	110	0.024
negative regulation of cell cycle process	GO:0010948	121	0.024
regulation of system process	GO:0044057	101	0.024
regulation of protein transport	GO:0051223	213	0.024
b cell proliferation	GO:0042100	22	0.024
embryonic organ development	GO:0048568	36	0.024
cell death in response to oxidative stress	GO:0036473	29	0.024
dna damage response signal transduction by p53 class mediator	GO:0030330	44	0.024
er to golgi vesicle mediated transport	GO:0006888	19	0.023
protein acetylation	GO:0006473	116	0.023
cellular response to organic cyclic compound	GO:0071407	127	0.023
myeloid cell differentiation	GO:0030099	117	0.023
male meiosis	GO:0007140	1	0.023
regulation of intracellular steroid hormone receptor signaling pathway	GO:0033143	32	0.023
regulation of cell growth	GO:0001558	135	0.023
regulation of notch signaling pathway	GO:0008593	18	0.022
vesicle targeting rough er to cis golgi	GO:0048207	2	0.022
viral life cycle	GO:0019058	132	0.022
epidermis development	GO:0008544	59	0.022
positive regulation of proteolysis involved in cellular protein catabolic process	GO:1903052	35	0.022
pathway restricted smad protein phosphorylation	GO:0060389	38	0.022
developmental growth	GO:0048589	48	0.022	Worm
citrate metabolic process	GO:0006101	2	0.022
mitotic cell cycle process	GO:1903047	286	0.022
copii vesicle coating	GO:0048208	2	0.021
amine metabolic process	GO:0009308	44	0.021
camera type eye morphogenesis	GO:0048593	12	0.021
positive regulation of transcription initiation from rna polymerase ii promoter	GO:0060261	4	0.021
regulation of cell activation	GO:0050865	125	0.021
response to other organism	GO:0051707	261	0.021
embryonic skeletal system morphogenesis	GO:0048704	9	0.021
system process	GO:0003008	349	0.021
cell cycle g1 s phase transition	GO:0044843	80	0.021
positive regulation of cell cycle process	GO:0090068	106	0.021
genetic imprinting	GO:0071514	1	0.021
nucleocytoplasmic transport	GO:0006913	176	0.021
negative regulation of phosphorus metabolic process	GO:0010563	267	0.020
regulation of metal ion transport	GO:0010959	120	0.020
negative regulation of dna replication	GO:0008156	29	0.020
establishment of apical basal cell polarity	GO:0035089	1	0.020
negative regulation of cellular protein catabolic process	GO:1903363	38	0.020
glycosylation	GO:0070085	71	0.020
multicellular organism reproduction	GO:0032504	42	0.020
embryonic skeletal system development	GO:0048706	13	0.020
regulation of potassium ion transmembrane transporter activity	GO:1901016	16	0.020
cellular response to oxygen containing compound	GO:1901701	276	0.019
regulation of viral transcription	GO:0046782	34	0.019
negative regulation of protein ubiquitination involved in ubiquitin dependent protein catabolic process	GO:2000059	3	0.019
positive regulation of cytoplasmic transport	GO:1903651	82	0.019
positive regulation of protein kinase activity	GO:0045860	190	0.019
negative regulation of kinase activity	GO:0033673	106	0.019
embryo development ending in birth or egg hatching	GO:0009792	34	0.019	Worm
neuron projection guidance	GO:0097485	12	0.019
methylation dependent chromatin silencing	GO:0006346	3	0.019
regulation of ion transport	GO:0043269	189	0.019
regulation of establishment of protein localization	GO:0070201	242	0.018
positive regulation of wnt signaling pathway	GO:0030177	54	0.018
cell projection organization	GO:0030030	252	0.018
regulation of actin filament based process	GO:0032970	141	0.018
negative regulation of multi organism process	GO:0043901	92	0.018
monoubiquitinated protein deubiquitination	GO:0035520	6	0.018
stem cell division	GO:0017145	2	0.018
appendage development	GO:0048736	23	0.018
negative regulation of intracellular transport	GO:0032387	60	0.018
histone lysine methylation	GO:0034968	50	0.018
regulation of transcription involved in g1 s transition of mitotic cell cycle	GO:0000083	8	0.018
regulation of gene expression epigenetic	GO:0040029	73	0.018	Fly
rhythmic process	GO:0048511	31	0.018
b cell activation	GO:0042113	33	0.017
rna interference	GO:0016246	4	0.017
positive regulation of intracellular transport	GO:0032388	104	0.017
viral transcription	GO:0019083	35	0.017
regulation of cytokine mediated signaling pathway	GO:0001959	41	0.017
regulation of mrna export from nucleus	GO:0010793	3	0.017
regulation of mrna metabolic process	GO:1903311	53	0.017
response to heat	GO:0009408	21	0.017
positive regulation of programmed cell death	GO:0043068	249	0.017	Rat
protein maturation	GO:0051604	233	0.017
peptidyl tyrosine phosphorylation	GO:0018108	170	0.017
regulation of neurogenesis	GO:0050767	82	0.017
sexual reproduction	GO:0019953	37	0.017
vesicle organization	GO:0016050	62	0.017
cytoplasmic transport	GO:0016482	379	0.017
retina development in camera type eye	GO:0060041	15	0.017
regulation of protein import into nucleus	GO:0042306	78	0.016
regulation of cell projection organization	GO:0031344	107	0.016
ncrna processing	GO:0034470	83	0.016
prostate gland development	GO:0030850	3	0.016
response to antibiotic	GO:0046677	15	0.016

USP7 disease predictions

Disease	DO term ID	Size	Probability
disease of cellular proliferation	DOID:14566	174	0.272
organ system cancer	DOID:0050686	164	0.164
cancer	DOID:162	167	0.164
sensory system disease	DOID:0050155	203	0.056
eye and adnexa disease	DOID:1492	150	0.056
nervous system disease	DOID:863	431	0.056
eye disease	DOID:5614	149	0.056
microphthalmia	DOID:10629	11	0.030
neurodegenerative disease	DOID:1289	102	0.025
central nervous system disease	DOID:331	186	0.025
spinocerebellar degeneration	DOID:2478	27	0.017

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