IMP: Integrative Multi-species Prediction

Homo sapiens

0 known processes

XRCC1

X-ray repair complementing defective repair in Chinese hamster cells 1

(Aliases: RCC)

Entrez: 7515
MIM: 194360
HGNC: 12828
Ensembl: ENSG00000073050
HPRD: 01909
UniProtKB: B2RCY5
UniProtKB: P18887
UniProtKB: Q59HH7

Process Predictions
Disease Predictions

XRCC1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
base excision repair	GO:0006284	21	0.999	Rat
dna damage response detection of dna damage	GO:0042769	3	0.990
dna repair	GO:0006281	198	0.974	Mouse Rat
dna ligation involved in dna repair	GO:0051103	4	0.920
cellular response to dna damage stimulus	GO:0006974	379	0.872	Mouse Rat
double strand break repair	GO:0006302	101	0.821
dephosphorylation	GO:0016311	209	0.652
detection of stimulus	GO:0051606	85	0.612
nucleic acid phosphodiester bond hydrolysis	GO:0090305	102	0.452
response to oxidative stress	GO:0006979	121	0.350
single strand break repair	GO:0000012	6	0.291
nucleotide excision repair	GO:0006289	31	0.240
nucleotide phosphorylation	GO:0046939	15	0.205
dna catabolic process	GO:0006308	49	0.196
negative regulation of dna metabolic process	GO:0051053	57	0.188
dna recombination	GO:0006310	77	0.177
signal transduction involved in regulation of gene expression	GO:0023019	1	0.175
cellular macromolecule catabolic process	GO:0044265	380	0.171
mitochondrion organization	GO:0007005	156	0.158
post embryonic development	GO:0009791	2	0.156
response to oxygen containing compound	GO:1901700	369	0.150
non recombinational repair	GO:0000726	14	0.121
dna ligation	GO:0006266	10	0.113
posttranscriptional regulation of gene expression	GO:0010608	213	0.109
response to hydrogen peroxide	GO:0042542	40	0.095
immunoglobulin v d j recombination	GO:0033152	1	0.094
response to reactive oxygen species	GO:0000302	61	0.094
single organism cellular localization	GO:1902580	332	0.089
protein ubiquitination	GO:0016567	314	0.081
regulation of dna metabolic process	GO:0051052	153	0.080
double strand break repair via nonhomologous end joining	GO:0006303	10	0.077
negative regulation of cell death	GO:0060548	345	0.077
base excision repair dna ligation	GO:0006288	2	0.075
response to radiation	GO:0009314	151	0.074
regulation of growth rate	GO:0040009	1	0.069
protein modification by small protein conjugation	GO:0032446	342	0.068
response to abiotic stimulus	GO:0009628	336	0.066	Rat
v d j recombination	GO:0033151	3	0.060
negative regulation of apoptotic process	GO:0043066	316	0.058
negative regulation of programmed cell death	GO:0043069	321	0.057
protein adp ribosylation	GO:0006471	9	0.055
carbohydrate metabolic process	GO:0005975	207	0.053
glycoprotein biosynthetic process	GO:0009101	91	0.052
cytoplasmic transport	GO:0016482	379	0.052
microtubule cytoskeleton organization	GO:0000226	176	0.051
enzyme linked receptor protein signaling pathway	GO:0007167	303	0.050
regulation of sequence specific dna binding transcription factor activity	GO:0051090	211	0.050
response to inorganic substance	GO:0010035	127	0.049
glycosylation	GO:0070085	71	0.047
viral life cycle	GO:0019058	132	0.046
dna biosynthetic process	GO:0071897	40	0.046
regulation of cellular response to stress	GO:0080135	244	0.045
protein import	GO:0017038	130	0.045
positive regulation of transcription regulatory region dna binding	GO:2000679	8	0.044
glycoprotein metabolic process	GO:0009100	110	0.044
single organism nuclear import	GO:1902593	104	0.043
regulation of response to dna damage stimulus	GO:2001020	94	0.043
negative regulation of protein metabolic process	GO:0051248	391	0.042
nucleotide catabolic process	GO:0009166	408	0.041
organophosphate catabolic process	GO:0046434	430	0.041
macromolecule glycosylation	GO:0043413	63	0.040
regulation of protein stability	GO:0031647	87	0.039
meiosis i	GO:0007127	4	0.038
protein targeting	GO:0006605	187	0.038
regulation of protein transport	GO:0051223	213	0.038
positive regulation of protein transport	GO:0051222	135	0.038
t cell differentiation in thymus	GO:0033077	4	0.038
protein catabolic process	GO:0030163	325	0.038
protein processing	GO:0016485	226	0.037
dna replication	GO:0006260	116	0.036
protein localization to organelle	GO:0033365	280	0.036
response to gamma radiation	GO:0010332	14	0.036
cellular response to oxygen radical	GO:0071450	6	0.036
rhythmic behavior	GO:0007622	2	0.035
immune response	GO:0006955	307	0.035
demethylation	GO:0070988	37	0.034
apoptotic signaling pathway	GO:0097190	268	0.034
protein localization to nucleus	GO:0034504	136	0.033
amine metabolic process	GO:0009308	44	0.033
vesicle mediated transport	GO:0016192	371	0.032
circulatory system development	GO:0072359	262	0.032
response to growth factor	GO:0070848	205	0.031
blastoderm segmentation	GO:0007350	2	0.031
glycosyl compound catabolic process	GO:1901658	413	0.030
regulation of dna repair	GO:0006282	47	0.030
purine nucleoside triphosphate catabolic process	GO:0009146	392	0.030
somatic diversification of immunoglobulins involved in immune response	GO:0002208	3	0.029
ribonucleoside triphosphate catabolic process	GO:0009203	391	0.029
generation of neurons	GO:0048699	152	0.029
epithelium development	GO:0060429	227	0.029
metencephalon development	GO:0022037	2	0.028
dna catabolic process exonucleolytic	GO:0000738	17	0.028
response to hyperoxia	GO:0055093	4	0.028
positive regulation of developmental process	GO:0051094	314	0.028
symbiosis encompassing mutualism through parasitism	GO:0044403	156	0.028
negative regulation of cellular protein metabolic process	GO:0032269	353	0.028
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.027
regulation of cellular amino acid metabolic process	GO:0006521	6	0.027
system process	GO:0003008	349	0.027
positive regulation of sequence specific dna binding transcription factor activity	GO:0051091	131	0.027
dna dealkylation	GO:0035510	13	0.027
cell cycle g2 m phase transition	GO:0044839	43	0.027
negative regulation of sequence specific dna binding transcription factor activity	GO:0043433	89	0.027
regulation of growth	GO:0040008	165	0.026
protein maturation	GO:0051604	233	0.026
negative regulation of phosphate metabolic process	GO:0045936	267	0.026
atp metabolic process	GO:0046034	176	0.026
dna demethylation	GO:0080111	12	0.026
carbohydrate derivative biosynthetic process	GO:1901137	207	0.026
positive regulation of cellular amine metabolic process	GO:0033240	7	0.026
regulation of cell differentiation	GO:0045595	393	0.026
regulation of protein localization	GO:0032880	296	0.026
cellular response to ionizing radiation	GO:0071479	32	0.025
establishment or maintenance of cytoskeleton polarity	GO:0030952	3	0.025
protein targeting to nucleus	GO:0044744	104	0.025
protein poly adp ribosylation	GO:0070212	3	0.025
determination of adult lifespan	GO:0008340	2	0.025
negative regulation of catalytic activity	GO:0043086	335	0.025
immune effector process	GO:0002252	159	0.025
nuclear import	GO:0051170	106	0.025
regulation of mitotic cell cycle	GO:0007346	189	0.024
negative regulation of phosphorus metabolic process	GO:0010563	267	0.024
positive regulation of cell proliferation	GO:0008284	301	0.024
nucleoside triphosphate metabolic process	GO:0009141	422	0.024
modification dependent protein catabolic process	GO:0019941	209	0.024
covalent chromatin modification	GO:0016569	254	0.023
ribonucleotide catabolic process	GO:0009261	405	0.023
cellular ketone metabolic process	GO:0042180	80	0.023
endomembrane system organization	GO:0010256	196	0.023
nucleoside catabolic process	GO:0009164	408	0.023
dna strand elongation involved in dna replication	GO:0006271	3	0.023
ras protein signal transduction	GO:0007265	73	0.023
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	90	0.023
cell projection organization	GO:0030030	252	0.022
response to increased oxygen levels	GO:0036296	4	0.022
intracellular protein transport	GO:0006886	270	0.022
regulation of multi organism process	GO:0043900	157	0.022
cellular macromolecular complex assembly	GO:0034622	324	0.022
single organism carbohydrate metabolic process	GO:0044723	193	0.022
regulation of cellular amine metabolic process	GO:0033238	11	0.022
axis elongation	GO:0003401	4	0.022
regulation of anatomical structure morphogenesis	GO:0022603	286	0.021
regulation of peptidase activity	GO:0052547	180	0.021
regulation of cardiac muscle tissue growth	GO:0055021	4	0.021
segmentation	GO:0035282	4	0.021
cellular component disassembly	GO:0022411	92	0.021
cell division	GO:0051301	168	0.021
microtubule based process	GO:0007017	210	0.021
telomere maintenance	GO:0000723	32	0.021
nucleoside monophosphate catabolic process	GO:0009125	159	0.021
nucleotide excision repair dna incision	GO:0033683	7	0.020
nuclear transport	GO:0051169	179	0.020
negative regulation of neuron apoptotic process	GO:0043524	23	0.020
ion homeostasis	GO:0050801	230	0.020
multi organism cellular process	GO:0044764	156	0.020
regulation of cell growth	GO:0001558	135	0.020
cellular response to transforming growth factor beta stimulus	GO:0071560	94	0.020
epidermis morphogenesis	GO:0048730	3	0.020
positive regulation of insulin like growth factor receptor signaling pathway	GO:0043568	4	0.020
purine ribonucleoside triphosphate metabolic process	GO:0009205	411	0.020
negative regulation of cell proliferation	GO:0008285	228	0.020
regulation of proteolysis	GO:0030162	293	0.020
interspecies interaction between organisms	GO:0044419	156	0.020
regulation of microtubule cytoskeleton organization	GO:0070507	61	0.020
circadian behavior	GO:0048512	2	0.019
regulation of keratinocyte apoptotic process	GO:1902172	1	0.019
peptidyl lysine acetylation	GO:0018394	101	0.019
protein acetylation	GO:0006473	116	0.019
regulation of protein modification by small protein conjugation or removal	GO:1903320	107	0.019
response to other organism	GO:0051707	261	0.019
regulation of cell cycle process	GO:0010564	266	0.019
regulation of gene expression epigenetic	GO:0040029	73	0.019
cell growth	GO:0016049	160	0.019
establishment of protein localization to organelle	GO:0072594	172	0.019
negative regulation of cellular component organization	GO:0051129	235	0.019
chemical homeostasis	GO:0048878	306	0.019
microtubule organizing center organization	GO:0031023	62	0.018
cerebellum development	GO:0021549	2	0.018
cellular response to growth factor stimulus	GO:0071363	197	0.018
protein import into nucleus	GO:0006606	104	0.018
neuron apoptotic process	GO:0051402	39	0.018
cilium morphogenesis	GO:0060271	75	0.018
regulation of dna recombination	GO:0000018	23	0.018
somitogenesis	GO:0001756	2	0.018
negative regulation of reactive oxygen species metabolic process	GO:2000378	11	0.018
transforming growth factor beta receptor signaling pathway	GO:0007179	76	0.018
hindbrain development	GO:0030902	3	0.018
mitotic cell cycle phase transition	GO:0044772	162	0.018
ribonucleoside triphosphate metabolic process	GO:0009199	412	0.018
compound eye development	GO:0048749	1	0.018
regulation of intracellular protein transport	GO:0033157	123	0.017
positive regulation of hydrolase activity	GO:0051345	331	0.017
rostrocaudal neural tube patterning	GO:0021903	1	0.017
regulation of cellular ketone metabolic process	GO:0010565	50	0.017
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	281	0.017
negative regulation of organelle organization	GO:0010639	126	0.017
convergent extension	GO:0060026	1	0.017
cellular amino acid metabolic process	GO:0006520	116	0.017
regulation of viral process	GO:0050792	103	0.017
response to transforming growth factor beta	GO:0071559	94	0.017
positive regulation of transport	GO:0051050	336	0.017
purine containing compound catabolic process	GO:0072523	411	0.017
membrane organization	GO:0061024	292	0.017
growth	GO:0040007	202	0.017
regulation of protein kinase activity	GO:0045859	289	0.017
cellular response to oxygen containing compound	GO:1901701	276	0.017
negative regulation of cell cycle process	GO:0010948	121	0.017
regulation of establishment of protein localization	GO:0070201	242	0.016
rho protein signal transduction	GO:0007266	26	0.016
cellular amine metabolic process	GO:0044106	41	0.016
regulation of transferase activity	GO:0051338	355	0.016
positive regulation of immune system process	GO:0002684	283	0.016
developmental programmed cell death	GO:0010623	3	0.016
regulation of protein import into nucleus	GO:0042306	78	0.016
regulation of kinase activity	GO:0043549	314	0.016
cardiovascular system development	GO:0072358	262	0.016
organelle assembly	GO:0070925	176	0.016
regulation of immune response	GO:0050776	201	0.016
actin filament based movement	GO:0030048	17	0.016
regulation of dna replication	GO:0006275	68	0.015
cytokinesis	GO:0000910	96	0.015
response to oxygen radical	GO:0000305	6	0.015
purine nucleoside catabolic process	GO:0006152	398	0.015
regulation of protein catabolic process	GO:0042176	155	0.015
positive regulation of intracellular transport	GO:0032388	104	0.015
cellular homeostasis	GO:0019725	196	0.015
regulation of cellular component movement	GO:0051270	334	0.015
cellular response to superoxide	GO:0071451	6	0.015
regulation of cytoplasmic transport	GO:1903649	149	0.015
histone modification	GO:0016570	251	0.015
intrinsic apoptotic signaling pathway by p53 class mediator	GO:0072332	37	0.014
negative regulation of nf kappab transcription factor activity	GO:0032088	51	0.014
positive regulation of cellular catabolic process	GO:0031331	284	0.014
cellular response to nitrogen compound	GO:1901699	144	0.014
viral process	GO:0016032	146	0.014
positive regulation of response to dna damage stimulus	GO:2001022	43	0.014
locomotory behavior	GO:0007626	1	0.014
signal transduction involved in mitotic dna integrity checkpoint	GO:1902403	13	0.014
signal transduction by phosphorylation	GO:0023014	297	0.014
nucleoside phosphate catabolic process	GO:1901292	412	0.014
cellular response to oxidative stress	GO:0034599	85	0.014
positive regulation of cell death	GO:0010942	263	0.014
cellular chemical homeostasis	GO:0055082	180	0.014
positive regulation of multi organism process	GO:0043902	56	0.014
nucleoside triphosphate catabolic process	GO:0009143	394	0.014
negative regulation of mitotic cell cycle phase transition	GO:1901991	85	0.014
telomere organization	GO:0032200	33	0.014
regulation of intracellular transport	GO:0032386	195	0.014
purine ribonucleoside triphosphate catabolic process	GO:0009207	391	0.014
anatomical structure formation involved in morphogenesis	GO:0048646	284	0.014
regulation of protein localization to nucleus	GO:1900180	85	0.014
positive regulation of cell differentiation	GO:0045597	211	0.014
oocyte differentiation	GO:0009994	2	0.014
meiotic chromosome segregation	GO:0045132	4	0.013
limbic system development	GO:0021761	3	0.013	Mouse
regulation of ligase activity	GO:0051340	29	0.013
positive regulation of nf kappab transcription factor activity	GO:0051092	81	0.013
dna duplex unwinding	GO:0032508	30	0.013
anatomical structure homeostasis	GO:0060249	100	0.013
positive regulation of cytoplasmic transport	GO:1903651	82	0.013
regulation of purine nucleotide catabolic process	GO:0033121	205	0.013
nervous system development	GO:0007399	293	0.013	Mouse
signal transduction involved in dna damage checkpoint	GO:0072422	15	0.013
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	125	0.013
mitotic cell cycle	GO:0000278	326	0.013
dna conformation change	GO:0071103	113	0.013
negative regulation of multicellular organismal process	GO:0051241	317	0.013
female gamete generation	GO:0007292	2	0.013
cellular component morphogenesis	GO:0032989	314	0.013
mapk cascade	GO:0000165	288	0.013
meiotic chromosome separation	GO:0051307	3	0.013
regulation of mitotic cell cycle phase transition	GO:1901990	118	0.013
blastocyst development	GO:0001824	3	0.013
negative regulation of hydrolase activity	GO:0051346	182	0.013
negative regulation of transferase activity	GO:0051348	124	0.013
positive regulation of intracellular protein transport	GO:0090316	76	0.013
proteolysis involved in cellular protein catabolic process	GO:0051603	244	0.013
signal transduction involved in dna integrity checkpoint	GO:0072401	15	0.013
ubiquitin dependent protein catabolic process	GO:0006511	206	0.013
cilium organization	GO:0044782	68	0.012
biological adhesion	GO:0022610	331	0.012
reciprocal dna recombination	GO:0035825	4	0.012
regulation of stress activated protein kinase signaling cascade	GO:0070302	85	0.012
cell projection morphogenesis	GO:0048858	129	0.012
negative regulation of cell cycle	GO:0045786	193	0.012
intra s dna damage checkpoint	GO:0031573	4	0.012
morphogenesis of a polarized epithelium	GO:0001738	3	0.012
regulation of protein targeting	GO:1903533	91	0.012
regulation of wnt signaling pathway	GO:0030111	123	0.012
oxidative stress induced premature senescence	GO:0090403	3	0.012
regulation of meiotic cell cycle	GO:0051445	4	0.012
chromosome segregation	GO:0007059	114	0.012
rna interference	GO:0016246	4	0.012
regulation of viral genome replication	GO:0045069	48	0.012
positive regulation of catabolic process	GO:0009896	310	0.012
guanosine containing compound catabolic process	GO:1901069	239	0.012
sleep	GO:0030431	2	0.012
hippocampus development	GO:0021766	1	0.012	Mouse
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090100	41	0.012
t cell lineage commitment	GO:0002360	1	0.012
oocyte development	GO:0048599	1	0.012
hemopoiesis	GO:0030097	180	0.012
positive regulation of protein phosphorylation	GO:0001934	313	0.012
centriole replication	GO:0007099	13	0.012
hematopoietic or lymphoid organ development	GO:0048534	186	0.012
signal transduction involved in mitotic dna damage checkpoint	GO:1902402	13	0.011
purine nucleotide catabolic process	GO:0006195	405	0.011
intrinsic apoptotic signaling pathway	GO:0097193	127	0.011
positive regulation of phosphorylation	GO:0042327	394	0.011
adult locomotory behavior	GO:0008344	1	0.011
ribonucleoside catabolic process	GO:0042454	406	0.011
epithelial cell differentiation	GO:0030855	141	0.011
cell adhesion	GO:0007155	325	0.011
regulation of vesicle mediated transport	GO:0060627	130	0.011
negative regulation of protein modification process	GO:0031400	200	0.011
regulation of mapk cascade	GO:0043408	262	0.011
regeneration	GO:0031099	4	0.011
regulation of transforming growth factor beta receptor signaling pathway	GO:0017015	48	0.011
negative regulation of dna replication	GO:0008156	29	0.011
intracellular receptor signaling pathway	GO:0030522	104	0.011
negative regulation of protein maturation	GO:1903318	142	0.011
neurological system process	GO:0050877	163	0.011
purine nucleoside triphosphate metabolic process	GO:0009144	412	0.011
reactive oxygen species metabolic process	GO:0072593	75	0.011
positive regulation of immune response	GO:0050778	159	0.011
internal peptidyl lysine acetylation	GO:0018393	97	0.011
establishment of planar polarity	GO:0001736	3	0.011
embryo development	GO:0009790	123	0.011
cellular response to organonitrogen compound	GO:0071417	124	0.011
thymocyte apoptotic process	GO:0070242	2	0.011
purine ribonucleoside catabolic process	GO:0046130	398	0.011
cell morphogenesis	GO:0000902	296	0.011
gtp metabolic process	GO:0046039	239	0.011
guanosine containing compound metabolic process	GO:1901068	244	0.011
pro b cell differentiation	GO:0002328	1	0.011
genetic imprinting	GO:0071514	1	0.011
response to organonitrogen compound	GO:0010243	156	0.011
proteasomal protein catabolic process	GO:0010498	176	0.011
metal ion transport	GO:0030001	272	0.011
negative regulation of phosphorylation	GO:0042326	174	0.011
cell part morphogenesis	GO:0032990	137	0.011
positive regulation of proteolysis	GO:0045862	142	0.011
regulation of cell cycle phase transition	GO:1901987	126	0.010
positive regulation of cellular component organization	GO:0051130	376	0.010
cell projection assembly	GO:0030031	126	0.010
negative regulation of heart growth	GO:0061117	2	0.010
single organism membrane organization	GO:0044802	268	0.010
cellular protein complex assembly	GO:0043623	188	0.010
positive regulation of dna metabolic process	GO:0051054	73	0.010
negative regulation of stem cell proliferation	GO:2000647	3	0.010
regulation of neural precursor cell proliferation	GO:2000177	4	0.010
protein acylation	GO:0043543	138	0.010
negative regulation of cellular amino acid metabolic process	GO:0045763	2	0.010
cellular response to endogenous stimulus	GO:0071495	336	0.010
regulation of synaptic plasticity	GO:0048167	3	0.010
regulation of dephosphorylation	GO:0035303	96	0.010
protein glycosylation	GO:0006486	62	0.010
neuroblast proliferation	GO:0007405	4	0.010
cilium assembly	GO:0042384	63	0.010
regulation of cell projection organization	GO:0031344	107	0.010
associative learning	GO:0008306	1	0.010
regulation of chromosome organization	GO:0033044	103	0.010
regulation of protein processing	GO:0070613	150	0.010
positive regulation of apoptotic process	GO:0043065	246	0.010
regulation of neuron apoptotic process	GO:0043523	35	0.010
positive regulation of nucleocytoplasmic transport	GO:0046824	54	0.010
calcium ion transport	GO:0006816	147	0.010
positive regulation of cellular component movement	GO:0051272	181	0.010
regulation of cell division	GO:0051302	116	0.010

XRCC1 disease predictions

Disease	DO term ID	Size	Probability
nervous system disease	DOID:863	431	0.998
neonatal period electroclinical syndrome	DOID:0050702	19	0.998
electroclinical syndrome	DOID:0050701	32	0.998
brain disease	DOID:936	73	0.998
central nervous system disease	DOID:331	186	0.998
epilepsy syndrome	DOID:1826	41	0.998
idiopathic generalized epilepsy	DOID:1827	21	0.299
ohtahara syndrome	DOID:0050709	17	0.165
disease of cellular proliferation	DOID:14566	174	0.108
cancer	DOID:162	167	0.069
infantile epileptic encephalopathy	DOID:2481	12	0.047
organ system cancer	DOID:0050686	164	0.044
primary ciliary dyskinesia	DOID:9562	27	0.030
gastrointestinal system cancer	DOID:3119	52	0.029
musculoskeletal system disease	DOID:17	223	0.021
eye disease	DOID:5614	149	0.021
eye and adnexa disease	DOID:1492	150	0.021
retinal disease	DOID:5679	118	0.021
sensory system disease	DOID:0050155	203	0.021
neurodegenerative disease	DOID:1289	102	0.020
musculoskeletal system cancer	DOID:0060100	11	0.014
connective tissue disease	DOID:65	109	0.013
thoracic cancer	DOID:5093	21	0.012
breast cancer	DOID:1612	21	0.012
cardiovascular system disease	DOID:1287	106	0.012
muscle tissue disease	DOID:66	113	0.012
myopathy	DOID:423	104	0.012
muscular disease	DOID:0080000	114	0.012
disease of metabolism	DOID:0014667	295	0.011
retinal degeneration	DOID:8466	89	0.011

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