Mus musculus

113 known processes

Hdac6

histone deacetylase 6

(Aliases: Sfc6,Hd6,Hdac5,mHDA2)

Hdac6 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
protein modification by small protein removalGO:0070646210.912
modification dependent macromolecule catabolic processGO:00436321330.775
cellular macromolecule catabolic processGO:00442652060.604
protein deubiquitinationGO:0016579190.575
macromolecule catabolic processGO:00090572810.559
proteolysis involved in cellular protein catabolic processGO:00516031470.484
cellular protein catabolic processGO:00442571550.434
histone modificationGO:00165701590.417
dna repairGO:00062811070.407
cellular response to dna damage stimulusGO:00069742070.352
covalent chromatin modificationGO:00165691630.345
protein catabolic processGO:00301632210.341
protein modification by small protein conjugation or removalGO:00706472070.341
ubiquitin dependent protein catabolic processGO:00065111290.324
protein modification by small protein conjugationGO:00324461870.262
cellular response to misfolded proteinGO:007121850.221
double strand break repair via nonhomologous end joiningGO:0006303100.192
protein ubiquitinationGO:00165671710.192
protein localization to organelleGO:00333651850.188
double strand break repairGO:0006302480.174
modification dependent protein catabolic processGO:00199411330.161
glycosyl compound metabolic processGO:19016572460.127
intracellular protein transportGO:00068862040.117
Human
cytoplasmic transportGO:00164822340.108
organonitrogen compound catabolic processGO:19015652640.098
translesion synthesisGO:001998510.098
ribonucleotide metabolic processGO:00092592910.096
nucleobase containing small molecule metabolic processGO:00550863520.090
organelle disassemblyGO:190300820.089
chromatin modificationGO:00165681870.089
aromatic compound catabolic processGO:00194392860.088
mitotic cell cycle processGO:19030471590.087
positive regulation of protein modification processGO:00314012990.085
chromatin organizationGO:00063252060.084
purine ribonucleoside triphosphate catabolic processGO:00092071990.084
purine ribonucleotide catabolic processGO:00091542080.080
cellular homeostasisGO:00197252400.079
transmembrane transportGO:00550854120.075
cellular ketone metabolic processGO:0042180840.075
positive regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043280360.074
histone deubiquitinationGO:001657820.074
ribonucleoside triphosphate catabolic processGO:00092031990.073
ribonucleoside triphosphate metabolic processGO:00091992200.072
regulation of proteolysisGO:00301621640.071
Human
purine nucleoside catabolic processGO:00061522050.069
membrane organizationGO:00610242450.067
nucleoside triphosphate metabolic processGO:00091412300.066
establishment of organelle localizationGO:00516561220.063
carbohydrate derivative catabolic processGO:19011362310.062
organelle membrane fusionGO:009017410.062
nucleotide catabolic processGO:00091662170.061
histone methylationGO:0016571710.061
ion transmembrane transportGO:00342203610.058
nucleoside phosphate metabolic processGO:00067533380.058
positive regulation of proteolysis involved in cellular protein catabolic processGO:1903052310.056
small gtpase mediated signal transductionGO:0007264970.056
positive regulation of cellular protein catabolic processGO:1903364340.055
development of primary sexual characteristicsGO:00451371430.054
organic cyclic compound catabolic processGO:19013612950.054
response to radiationGO:00093141650.054
nitrogen compound transportGO:00717052710.054
nucleoside triphosphate catabolic processGO:00091432050.053
positive regulation of proteasomal ubiquitin dependent protein catabolic processGO:0032436230.053
purine nucleoside metabolic processGO:00422782410.052
regulation of cellular catabolic processGO:00313292420.052
nucleotide metabolic processGO:00091173320.052
meiotic nuclear divisionGO:00071261150.051
regulation of peptidase activityGO:0052547960.050
heterocycle catabolic processGO:00467002800.050
purine containing compound metabolic processGO:00725213110.049
glycosyl compound catabolic processGO:19016582060.049
response to misfolded proteinGO:005178850.048
dna metabolic processGO:00062593030.047
regulation of cell cycleGO:00517262810.047
negative regulation of protein metabolic processGO:00512482820.047
Human
microtubule cytoskeleton organizationGO:00002261570.046
positive regulation of protein catabolic processGO:0045732600.046
purine nucleotide metabolic processGO:00061633020.045
cellular nitrogen compound catabolic processGO:00442702800.044
positive regulation of hydrolase activityGO:00513451480.044
ribonucleoside metabolic processGO:00091192450.043
ribose phosphate metabolic processGO:00196932910.041
purine nucleoside triphosphate metabolic processGO:00091442260.041
cellular amide metabolic processGO:0043603580.040
purine nucleoside triphosphate catabolic processGO:00091462030.040
mitotic cell cycleGO:00002781950.039
nucleoside metabolic processGO:00091162460.039
nuclear transportGO:00511691390.039
proteasomal protein catabolic processGO:0010498980.038
ribonucleoside monophosphate catabolic processGO:0009158570.038
purine ribonucleotide metabolic processGO:00091502900.038
regulation of cellular protein catabolic processGO:1903362610.038
nucleoside catabolic processGO:00091642060.037
antimicrobial peptide productionGO:000277520.037
protein targetingGO:00066051430.037
learning or memoryGO:00076111480.035
ribonucleotide catabolic processGO:00092612080.035
protein import into nucleusGO:0006606950.035
positive regulation of apoptotic processGO:00430652170.035
dna biosynthetic processGO:0071897220.035
attachment of spindle microtubules to kinetochoreGO:000860840.034
regulation of endopeptidase activityGO:0052548890.033
protein maturationGO:00516041760.032
Human
nucleoside phosphate catabolic processGO:19012922220.032
regulation of protein deubiquitinationGO:009008510.032
non recombinational repairGO:0000726100.032
protein k63 linked deubiquitinationGO:007053610.031
cation transportGO:00068123990.031
macromolecule methylationGO:00434141200.031
peptide metabolic processGO:0006518460.031
regulation of microtubule cytoskeleton organizationGO:0070507370.031
gland developmentGO:00487323300.031
male gamete generationGO:00482322850.030
purine ribonucleoside catabolic processGO:00461302050.030
immune effector processGO:00022523210.030
purine nucleotide catabolic processGO:00061952110.030
ubiquitin dependent protein catabolic process via the multivesicular body sorting pathwayGO:004316230.030
regulation of transferase activityGO:00513382630.030
tube closureGO:0060606910.029
nuclear importGO:0051170950.029
purine containing compound catabolic processGO:00725232130.029
primary neural tube formationGO:0014020950.029
nucleoside monophosphate catabolic processGO:0009125590.028
negative regulation of cell proliferationGO:00082852960.028
ribonucleoside catabolic processGO:00424542060.028
response to light stimulusGO:00094161350.028
regulation of synaptic growth at neuromuscular junctionGO:000858240.028
spermatogenesisGO:00072832840.028
organophosphate catabolic processGO:00464342320.028
regulation of mitotic cell cycleGO:00073461260.027
neural tube developmentGO:00219151600.027
positive regulation of organelle organizationGO:00106381280.027
purine ribonucleoside triphosphate metabolic processGO:00092052200.027
organic anion transportGO:00157111370.027
regulation of peptide transportGO:0090087910.027
positive regulation of cellular catabolic processGO:00313311480.026
inclusion body assemblyGO:007084130.026
positive regulation of bindingGO:0051099490.026
positive regulation of protein phosphorylationGO:00019342420.025
regulation of protein localizationGO:00328802310.025
nucleocytoplasmic transportGO:00069131390.025
protein complex disassemblyGO:0043241400.025
multicellular organism growthGO:00352641610.025
purine ribonucleoside metabolic processGO:00461282410.025
protein ubiquitination involved in ubiquitin dependent protein catabolic processGO:0042787250.025
wnt signaling pathwayGO:00160551880.025
regulation of mapk cascadeGO:00434082480.025
maintenance of locationGO:0051235890.025
proteasome mediated ubiquitin dependent protein catabolic processGO:0043161880.025
regulation of protein transportGO:00512231630.025
cellular response to inorganic substanceGO:0071241370.025
regulation of intracellular transportGO:00323861590.024
regulation of microtubule based processGO:0032886520.024
dephosphorylationGO:00163111290.024
response to uvGO:0009411440.024
cell type specific apoptotic processGO:00972852680.024
atp catabolic processGO:0006200550.024
regulation of protein import into nucleusGO:0042306520.024
anatomical structure homeostasisGO:00602491450.024
anion transportGO:00068201770.024
purine ribonucleoside monophosphate metabolic processGO:0009167800.024
neural tube closureGO:0001843900.023
negative regulation of nervous system developmentGO:00519611560.023
negative regulation of intracellular signal transductionGO:19025321670.023
positive regulation of cell deathGO:00109422240.023
Human
regulation of intracellular protein transportGO:0033157820.023
mapk cascadeGO:00001652810.023
establishment of protein localization to organelleGO:00725941180.023
cellular amino acid metabolic processGO:00065201030.023
rho protein signal transductionGO:0007266320.023
rna interferenceGO:001624620.022
posttranscriptional regulation of gene expressionGO:00106081550.022
telencephalon developmentGO:00215371860.022
ribonucleoside monophosphate metabolic processGO:0009161800.022
gonad developmentGO:00084061410.022
regulation of protein localization to nucleusGO:1900180600.022
response to nutrient levelsGO:00316671090.022
Human
positive regulation of proteolysisGO:0045862850.021
regulation of transcription factor import into nucleusGO:0042990240.021
sensory perceptionGO:00076002450.021
cognitionGO:00508901490.021
morphogenesis of embryonic epitheliumGO:00163311590.021
histone lysine methylationGO:0034968500.021
response to organic cyclic compoundGO:00140701980.021
microtubule based processGO:00070172360.020
regulation of antimicrobial humoral responseGO:000275930.020
cellular response to lipidGO:00713961450.020
lipid homeostasisGO:0055088630.020
amine metabolic processGO:0009308450.020
sterol metabolic processGO:0016125580.020
negative regulation of intracellular protein transportGO:0090317270.020
regulation of proteolysis involved in cellular protein catabolic processGO:1903050560.020
skin developmentGO:00435882200.020
regulation of cellular ketone metabolic processGO:0010565660.020
protein localization to membraneGO:00726571080.020
protein n linked glycosylationGO:0006487120.020
regulation of protein serine threonine kinase activityGO:00719001570.019
anion transmembrane transportGO:0098656710.019
oocyte constructionGO:000730820.019
protein oligomerizationGO:0051259670.019
regulation of cell sizeGO:0008361720.019
regulation of protein ubiquitinationGO:0031396520.019
protein methylationGO:0006479810.019
regulation of vesicle mediated transportGO:00606271390.019
organelle fissionGO:00482851700.019
positive regulation of histone modificationGO:0031058280.018
positive regulation of protein modification by small protein conjugation or removalGO:1903322300.018
autophagyGO:0006914450.018
Human
neural tube formationGO:00018411080.018
protein importGO:00170381010.018
positive regulation of programmed cell deathGO:00430682180.018
Human
regulation of cell activationGO:00508652890.018
regulation of chromosome organizationGO:0033044830.018
stem cell proliferationGO:00720891170.018
negative regulation of neuron deathGO:1901215980.018
cation transmembrane transportGO:00986552660.018
acylglycerol homeostasisGO:0055090160.018
atp metabolic processGO:0046034750.018
regulation of hydrolase activityGO:00513362460.018
negative regulation of protein transportGO:0051224460.017
methylationGO:00322591340.017
regulation of protein bindingGO:0043393600.017
negative regulation of intracellular transportGO:0032387380.017
positive regulation of protein serine threonine kinase activityGO:00719021060.017
response to peptideGO:19016521360.017
regulation of dna replicationGO:0006275170.017
neuron migrationGO:00017641220.016
regulation of neuron differentiationGO:00456642810.016
cellular ion homeostasisGO:00068731650.016
negative regulation of growthGO:0045926990.016
protein homooligomerizationGO:0051260430.016
regulation of transmembrane transportGO:00347621280.016
regulation of histone modificationGO:0031056560.016
response to organonitrogen compoundGO:00102432460.016
negative regulation of molecular functionGO:00440922580.015
carbohydrate metabolic processGO:00059752300.015
alcohol metabolic processGO:00060661160.015
meiotic cell cycleGO:00513211220.015
germ cell developmentGO:00072811850.015
activation of cysteine type endopeptidase activity involved in apoptotic processGO:0006919270.015
positive regulation of peptidase activityGO:0010952490.015
inorganic cation transmembrane transportGO:00986622070.015
dna replicationGO:0006260520.015
histone ubiquitinationGO:0016574100.015
positive regulation of endopeptidase activityGO:0010950430.015
synapsisGO:0007129340.015
positive regulation of apoptotic signaling pathwayGO:2001235950.015
epidermis developmentGO:00085441870.015
purine nucleoside monophosphate catabolic processGO:0009128580.014
positive regulation of gtpase activityGO:0043547850.014
negative regulation of phosphorylationGO:00423261660.014
regulation of protein kinase activityGO:00458592320.014
regulation of cysteine type endopeptidase activityGO:2000116650.014
lipid localizationGO:00108761260.014
extrinsic apoptotic signaling pathwayGO:00971911260.014
fertilizationGO:00095661270.014
negative regulation of cellular component organizationGO:00511291940.014
metencephalon developmentGO:0022037890.014
positive regulation of cellular amino acid metabolic processGO:004576430.014
nerve developmentGO:0021675670.014
locomotory behaviorGO:00076261950.014
regulation of nucleocytoplasmic transportGO:0046822730.014
regulation of protein maturationGO:1903317960.014
Human
regulation of cellular component sizeGO:00325351210.014
organonitrogen compound biosynthetic processGO:19015661920.014
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043281620.014
skeletal system developmentGO:00015013560.014
purine nucleoside monophosphate metabolic processGO:0009126810.014
synaptic transmissionGO:00072683290.014
regulation of apoptotic signaling pathwayGO:20012331970.014
regulation of cell morphogenesis involved in differentiationGO:00107691510.013
regulation of organelle organizationGO:00330432890.013
chromosome segregationGO:0007059480.013
respiratory system developmentGO:00605411900.013
rna processingGO:00063961050.013
negative regulation of nucleocytoplasmic transportGO:0046823230.013
regulation of cytoplasmic transportGO:19036491120.013
cellular amine metabolic processGO:0044106440.013
cellular response to hormone stimulusGO:00328701500.013
regulation of neuron deathGO:19012141340.013
nuclear exportGO:0051168340.013
lymphocyte differentiationGO:00300982420.013
negative regulation of protein localization to nucleusGO:1900181230.013
single organism nuclear importGO:1902593950.013
glycoprotein metabolic processGO:00091001160.013
regulation of ion transmembrane transportGO:00347651190.013
respiratory tube developmentGO:00303231670.013
purine ribonucleoside monophosphate catabolic processGO:0009169570.013
regulation of bindingGO:00510981110.013
cranial nerve formationGO:002160340.013
innate immune responseGO:00450871570.013
response to extracellular stimulusGO:00099911270.013
Human
regulation of cell projection organizationGO:00313442060.013
extracellular matrix organizationGO:00301981470.013
protein polyubiquitinationGO:0000209330.012
inorganic ion transmembrane transportGO:00986602340.012
cholesterol transportGO:0030301380.012
hematopoietic stem cell proliferationGO:0071425130.012
cellular response to organic cyclic compoundGO:0071407870.012
regulation of nucleotide metabolic processGO:00061401690.012
regulation of wnt signaling pathwayGO:00301111230.012
oocyte anterior posterior axis specificationGO:000731420.012
tube formationGO:00351481400.012
ras protein signal transductionGO:0007265770.012
organic hydroxy compound metabolic processGO:19016152030.012
single fertilizationGO:0007338820.012
carbohydrate biosynthetic processGO:0016051740.012
positive regulation of kinase activityGO:00336741550.012
epithelial tube morphogenesisGO:00605623030.012
positive regulation of cellular amine metabolic processGO:003324050.012
regulation of cellular component biogenesisGO:00440871810.012
Human
regulation of reactive oxygen species biosynthetic processGO:190342620.012
pole plasm assemblyGO:000731520.012
axon target recognitionGO:000741240.012
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781940.012
regulation of protein targetingGO:1903533610.012
receptor mediated endocytosisGO:0006898510.012
regulation of protein catabolic processGO:00421761080.012
regulation of ras protein signal transductionGO:00465781140.011
defense response to other organismGO:00985421970.011
cellular response to extracellular stimulusGO:0031668810.011
Human
negative regulation of cellular protein metabolic processGO:00322692470.011
Human
bone developmentGO:00603481200.011
reactive oxygen species biosynthetic processGO:190340980.011
positive regulation of cellular component biogenesisGO:0044089940.011
Human
spermatid developmentGO:00072861080.011
regulation of protein modification by small protein conjugation or removalGO:1903320570.011
gtp metabolic processGO:00460391440.011
regulation of leukocyte differentiationGO:19021051590.011
regulation of cytoskeleton organizationGO:00514931220.011
positive regulation of protein ubiquitinationGO:0031398270.011
antimicrobial peptide biosynthetic processGO:000277720.011
positive regulation of transferase activityGO:00513471670.011
positive regulation of chromatin modificationGO:1903310280.011
positive regulation of protein kinase activityGO:00458601440.011
aggresome assemblyGO:007084220.011
response to lipopolysaccharideGO:00324961280.011
cranial nerve developmentGO:0021545410.011
regulation of extrinsic apoptotic signaling pathwayGO:2001236770.011
spermatid differentiationGO:00485151150.011
response to sterolGO:003631440.011
response to molecule of bacterial originGO:00022371430.011
transcription factor import into nucleusGO:0042991260.011
multicellular organismal homeostasisGO:00488711640.010
regulation of cellular amine metabolic processGO:0033238200.010
establishment of protein localization to membraneGO:0090150540.010
regulation of reactive oxygen species metabolic processGO:2000377400.010
response to peptide hormoneGO:00434341270.010
canonical wnt signaling pathwayGO:00600701300.010
sodium ion transportGO:0006814730.010
positive regulation of reactive oxygen species biosynthetic processGO:190342820.010
sensory system developmentGO:004888030.010
neuron deathGO:00709971540.010
positive regulation of nucleotide metabolic processGO:00459811140.010
cholesterol metabolic processGO:0008203560.010
regulation of autophagyGO:0010506300.010
peptidyl asparagine modificationGO:001819610.010
thermosensory behaviorGO:004004010.010
cellular response to organonitrogen compoundGO:00714171450.010
defense response to bacteriumGO:00427421190.010
vesicle localizationGO:0051648860.010

Hdac6 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
nervous system diseaseDOID:86300.224
disease of anatomical entityDOID:700.224
central nervous system diseaseDOID:33100.170
neurodegenerative diseaseDOID:128900.066
motor neuron diseaseDOID:23100.029
retinal diseaseDOID:567900.028
eye diseaseDOID:561400.028
eye and adnexa diseaseDOID:149200.028
sensory system diseaseDOID:005015500.028
physical disorderDOID:008001500.028
retinal degenerationDOID:846600.023
congenital nervous system abnormalityDOID:249000.021
amyotrophic lateral sclerosisDOID:33200.018
inherited metabolic disorderDOID:65500.015
disease of metabolismDOID:001466700.015
retinitis pigmentosaDOID:1058400.013
neuromuscular diseaseDOID:44000.010
neuropathyDOID:87000.010