Mus musculus

148 known processes

Dock8

dedicator of cytokinesis 8

(Aliases: A130095G14Rik,AI461977,1200017A24Rik,5830472H07Rik)

Dock8 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
nucleoside phosphate metabolic processGO:00067533380.156
purine ribonucleoside triphosphate catabolic processGO:00092071990.102
regulation of hydrolase activityGO:00513362460.100
purine nucleotide metabolic processGO:00061633020.099
cellular nitrogen compound catabolic processGO:00442702800.092
positive regulation of gtp catabolic processGO:0033126850.089
ribonucleoside triphosphate catabolic processGO:00092031990.087
small gtpase mediated signal transductionGO:0007264970.087
Fly
purine ribonucleoside catabolic processGO:00461302050.084
nucleotide metabolic processGO:00091173320.083
ras protein signal transductionGO:0007265770.083
Fly
purine ribonucleotide metabolic processGO:00091502900.079
purine containing compound catabolic processGO:00725232130.078
purine nucleoside metabolic processGO:00422782410.076
ribonucleotide metabolic processGO:00092592910.075
carbohydrate derivative catabolic processGO:19011362310.074
glycosyl compound metabolic processGO:19016572460.073
regulation of nucleotide metabolic processGO:00061401690.071
immune response regulating signaling pathwayGO:00027641250.070
amine metabolic processGO:0009308450.069
rho protein signal transductionGO:0007266320.069
Fly
guanosine containing compound metabolic processGO:19010681440.069
purine ribonucleoside triphosphate metabolic processGO:00092052200.068
glycosyl compound catabolic processGO:19016582060.067
nucleoside catabolic processGO:00091642060.066
organonitrogen compound catabolic processGO:19015652640.064
nucleoside phosphate catabolic processGO:19012922220.064
purine nucleotide catabolic processGO:00061952110.063
purine containing compound metabolic processGO:00725213110.061
regulation of cellular catabolic processGO:00313292420.060
immune response activating signal transductionGO:00027571160.060
nucleobase containing small molecule metabolic processGO:00550863520.058
immune response activating cell surface receptor signaling pathwayGO:0002429720.056
activation of immune responseGO:00022531380.056
ribonucleotide catabolic processGO:00092612080.055
nucleoside triphosphate metabolic processGO:00091412300.055
purine nucleoside triphosphate catabolic processGO:00091462030.055
cellular amino acid metabolic processGO:00065201030.054
purine nucleoside catabolic processGO:00061522050.054
heterocycle catabolic processGO:00467002800.054
ribonucleoside triphosphate metabolic processGO:00091992200.053
cellular ketone metabolic processGO:0042180840.050
regulation of cellular ketone metabolic processGO:0010565660.050
regulation of cellular amino acid metabolic processGO:000652150.049
positive regulation of purine nucleotide metabolic processGO:19005441140.047
nucleotide catabolic processGO:00091662170.047
aromatic compound catabolic processGO:00194392860.047
nucleoside metabolic processGO:00091162460.046
cellular amine metabolic processGO:0044106440.046
membrane organizationGO:00610242450.045
organophosphate catabolic processGO:00464342320.045
purine ribonucleoside metabolic processGO:00461282410.044
t cell activationGO:00421102890.043
Human
regulation of nucleotide catabolic processGO:00308111220.043
positive regulation of cellular catabolic processGO:00313311480.043
ribonucleoside catabolic processGO:00424542060.043
ribose phosphate metabolic processGO:00196932910.043
cation transportGO:00068123990.042
gtp metabolic processGO:00460391440.042
positive regulation of gtpase activityGO:0043547850.042
purine ribonucleotide catabolic processGO:00091542080.041
ribonucleoside metabolic processGO:00091192450.040
cellular lipid metabolic processGO:00442553230.039
divalent inorganic cation transportGO:00725111780.039
nucleoside triphosphate catabolic processGO:00091432050.038
ion transmembrane transportGO:00342203610.037
purine nucleoside triphosphate metabolic processGO:00091442260.037
guanosine containing compound catabolic processGO:19010691440.037
leukocyte differentiationGO:00025213420.036
reactive oxygen species metabolic processGO:0072593840.035
regulation of vesicle mediated transportGO:00606271390.035
positive regulation of hydrolase activityGO:00513451480.035
immune effector processGO:00022523210.035
Fly
organic cyclic compound catabolic processGO:19013612950.034
regulation of cellular amine metabolic processGO:0033238200.034
peptidyl amino acid modificationGO:00181933360.033
regulation of purine nucleotide metabolic processGO:19005421690.033
cation transmembrane transportGO:00986552660.033
positive regulation of nucleotide metabolic processGO:00459811140.033
regulation of purine nucleotide catabolic processGO:00331211220.033
positive regulation of cellular amino acid metabolic processGO:004576430.032
regulation of ras protein signal transductionGO:00465781140.032
Mouse Fly
immune response regulating cell surface receptor signaling pathwayGO:0002768800.032
negative regulation of protein metabolic processGO:00512482820.032
innate immune responseGO:00450871570.032
Fly
synaptic transmissionGO:00072683290.032
gtp catabolic processGO:00061841430.031
macromolecule catabolic processGO:00090572810.031
sequestering of calcium ionGO:0051208180.031
actin cytoskeleton organizationGO:00300362200.030
protein catabolic processGO:00301632210.030
positive regulation of purine nucleotide catabolic processGO:0033123880.029
divalent metal ion transportGO:00708381720.029
myeloid cell differentiationGO:00300992330.029
regulation of organelle organizationGO:00330432890.029
regulation of ras gtpase activityGO:0032318880.028
Mouse Fly
negative regulation of cellular amino acid metabolic processGO:004576300.028
inorganic ion transmembrane transportGO:00986602340.028
maintenance of locationGO:0051235890.027
regulation of gtp catabolic processGO:00331241130.027
regulation of reactive oxygen species biosynthetic processGO:190342620.027
sensory perceptionGO:00076002450.027
negative regulation of cellular amine metabolic processGO:003323910.027
cellular calcium ion homeostasisGO:00068741190.026
positive regulation of cellular amine metabolic processGO:003324050.026
transmembrane transportGO:00550854120.026
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071692470.026
response to molecule of bacterial originGO:00022371430.025
regulation of cell cycleGO:00517262810.025
cellular ion homeostasisGO:00068731650.024
regulation of synaptic growth at neuromuscular junctionGO:000858240.024
cellular homeostasisGO:00197252400.024
regulation of cell motilityGO:20001452360.024
regulation of nucleoside metabolic processGO:00091181300.024
positive regulation of protein modification processGO:00314012990.024
inorganic cation transmembrane transportGO:00986622070.023
monocarboxylic acid metabolic processGO:00327871910.023
regulation of cell activationGO:00508652890.023
regulation of cell migrationGO:00303342190.023
g protein coupled receptor signaling pathwayGO:00071862430.023
positive regulation of ras gtpase activityGO:0032320650.022
Mouse Fly
organelle assemblyGO:00709251770.022
multicellular organismal homeostasisGO:00488711640.022
wound healingGO:00420601570.022
cellular response to molecule of bacterial originGO:0071219830.022
positive regulation of nucleotide catabolic processGO:0030813880.022
cell adhesionGO:00071553290.022
positive regulation of rac gtpase activityGO:0032855140.022
homeostasis of number of cellsGO:00488722100.022
antigen receptor mediated signaling pathwayGO:0050851640.022
protein modification by small protein conjugation or removalGO:00706472070.022
positive regulation of nucleoside metabolic processGO:0045979910.022
oxidation reduction processGO:00551143420.021
cation homeostasisGO:00550802120.021
sequestering of metal ionGO:0051238190.021
regulation of mapk cascadeGO:00434082480.021
organelle localizationGO:00516401790.021
Mouse
regulation of lymphocyte activationGO:00512492400.021
reactive nitrogen species metabolic processGO:200105700.021
activation of innate immune responseGO:0002218560.020
positive regulation of cytokine productionGO:00018191740.020
regulation of body fluid levelsGO:00508781620.020
cytoplasmic transportGO:00164822340.020
regulation of secretionGO:00510462740.020
regulation of cell projection organizationGO:00313442060.020
divalent inorganic cation homeostasisGO:00725071380.020
phagocytosisGO:0006909660.019
Fly
regulation of interferon beta biosynthetic processGO:004535740.019
muscle tissue developmentGO:00605373080.019
glycoprotein biosynthetic processGO:0009101890.019
anion transportGO:00068201770.019
nuclear divisionGO:00002801580.019
negative regulation of immune system processGO:00026832090.019
regulation of cytokine productionGO:00018172660.019
response to organonitrogen compoundGO:00102432460.019
protein modification by small protein conjugationGO:00324461870.019
glycoprotein metabolic processGO:00091001160.019
negative regulation of cellular component organizationGO:00511291940.018
endocytosisGO:00068971680.018
Fly
gland developmentGO:00487323300.018
multicellular organism growthGO:00352641610.018
cellular chemical homeostasisGO:00550822150.018
mapk cascadeGO:00001652810.018
negative regulation of cell proliferationGO:00082852960.018
respiratory system developmentGO:00605411900.018
negative regulation of phosphorylationGO:00423261660.018
single organism cell adhesionGO:00986021560.017
protein ubiquitinationGO:00165671710.017
anatomical structure homeostasisGO:00602491450.017
regulation of endocytosisGO:0030100690.017
response to acid chemicalGO:00011011110.017
negative regulation of cellular protein metabolic processGO:00322692470.017
regulation of actin nucleationGO:005112540.017
exocytosisGO:00068871210.017
cognitionGO:00508901490.017
chromatin modificationGO:00165681870.017
single organismal cell cell adhesionGO:00163371310.017
response to lipopolysaccharideGO:00324961280.017
tissue homeostasisGO:00018941150.017
axonogenesisGO:00074092740.017
kidney developmentGO:00018222130.017
cellular component assembly involved in morphogenesisGO:00109271390.017
regulation of cytoskeleton organizationGO:00514931220.017
compound eye developmentGO:004874910.016
cell substrate adhesionGO:00315891300.016
negative regulation of intracellular signal transductionGO:19025321670.016
actin filament organizationGO:00070151130.016
reactive oxygen species biosynthetic processGO:190340980.016
interferon beta biosynthetic processGO:004535040.016
regulation of rho protein signal transductionGO:0035023710.016
Mouse Fly
regulation of reactive oxygen species metabolic processGO:2000377400.016
renal system developmentGO:00720012250.016
positive regulation of protein phosphorylationGO:00019342420.016
regulation of membrane potentialGO:00423911920.016
blood vessel morphogenesisGO:00485142850.016
regulation of transferase activityGO:00513382630.016
regulation of actin filament based processGO:0032970990.016
regulation of secretion by cellGO:19035302490.016
telencephalon developmentGO:00215371860.016
neural precursor cell proliferationGO:00613511210.016
Mouse
skeletal muscle organ developmentGO:00605381630.016
organophosphate biosynthetic processGO:00904071220.016
regionalizationGO:00030023370.016
monocyte extravasationGO:003569620.016
learning or memoryGO:00076111480.016
endomembrane system organizationGO:00102561470.016
lipid localizationGO:00108761260.016
regulation of ion transportGO:00432692150.015
organonitrogen compound biosynthetic processGO:19015661920.015
carbohydrate derivative biosynthetic processGO:19011371830.015
calcium ion homeostasisGO:00550741270.015
establishment of organelle localizationGO:00516561220.015
cell activation involved in immune responseGO:00022631260.015
digestive system developmentGO:00551232000.015
cytokine productionGO:00018163190.015
regulation of kinase activityGO:00435492490.015
negative regulation of molecular functionGO:00440922580.015
regulation of innate immune responseGO:0045088910.015
cellular response to lipidGO:00713961450.015
positive regulation of reactive oxygen species biosynthetic processGO:190342820.015
regulation of anatomical structure sizeGO:00900661780.015
protein maturationGO:00516041760.015
myeloid leukocyte differentiationGO:00025731190.015
carbohydrate metabolic processGO:00059752300.015
male gamete generationGO:00482322850.015
modification dependent protein catabolic processGO:00199411330.015
forebrain developmentGO:00309003020.015
Mouse
nitrogen compound transportGO:00717052710.015
mitotic cell cycleGO:00002781950.015
organelle fissionGO:00482851700.015
regulation of actin cytoskeleton organizationGO:0032956840.015
positive regulation of cell deathGO:00109422240.015
negative regulation of synapse assemblyGO:005196430.015
ubiquitin dependent protein catabolic processGO:00065111290.015
b cell activationGO:00421131610.014
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781940.014
regulation of defense responseGO:00313472330.014
lung developmentGO:00303241640.014
negative regulation of homeostatic processGO:0032845710.014
chemotaxisGO:00069352470.014
regulation of cellular component biogenesisGO:00440871810.014
cell divisionGO:00513011200.014
positive regulation of transferase activityGO:00513471670.014
lymphocyte proliferationGO:00466511640.014
Human
microtubule based processGO:00070172360.014
lymphocyte differentiationGO:00300982420.014
regulation of myeloid cell differentiationGO:0045637960.014
regulation of establishment of protein localizationGO:00702011810.014
establishment of vesicle localizationGO:0051650810.014
retrograde transport endosome to golgiGO:004214720.014
calcium ion transportGO:00068161590.014
germ cell developmentGO:00072811850.014
t cell receptor signaling pathwayGO:0050852460.014
inflammatory responseGO:00069542440.014
placenta developmentGO:00018901400.014
positive regulation of secretion by cellGO:19035321140.014
epithelial cell proliferationGO:00506731740.014
cellular macromolecule catabolic processGO:00442652060.014
interleukin 6 productionGO:0032635580.014
regulation of apoptotic signaling pathwayGO:20012331970.014
cofactor transportGO:005118140.014
regulation of homeostatic processGO:00328441820.014
gonad developmentGO:00084061410.014
cellular metal ion homeostasisGO:00068751510.014
dna metabolic processGO:00062593030.014
glycerolipid metabolic processGO:00464861220.014
regulation of phospholipase c activityGO:190027430.013
alcohol metabolic processGO:00060661160.013
protein processingGO:00164851630.013
response to growth factorGO:00708481980.013
cellular protein complex assemblyGO:00436231160.013
positive regulation of interferon alpha productionGO:003272740.013
cell type specific apoptotic processGO:00972852680.013
urogenital system developmentGO:00016552610.013
spermatogenesisGO:00072832840.013
ameboidal type cell migrationGO:00016671280.013
coagulationGO:0050817780.013
defecationGO:003042110.013
metal ion homeostasisGO:00550651890.013
macromolecule glycosylationGO:0043413550.013
cellular response to lipopolysaccharideGO:0071222770.013
response to starvationGO:0042594650.013
lateral inhibitionGO:004633110.013
carbohydrate homeostasisGO:00335001280.013
modification dependent macromolecule catabolic processGO:00436321330.013
positive regulation of cell developmentGO:00107202370.013
regulation of neuron differentiationGO:00456642810.013
positive regulation of apoptotic processGO:00430652170.013
ossificationGO:00015032160.013
negative regulation of cell developmentGO:00107211690.013
alpha beta t cell activationGO:0046631910.013
regulation of cellular component sizeGO:00325351210.013
positive regulation of defense responseGO:00313491240.013
lipid transportGO:0006869980.013
cellular response to biotic stimulusGO:0071216920.013
regulation of protein complex assemblyGO:0043254830.013
cellular protein catabolic processGO:00442571550.013
organic hydroxy compound metabolic processGO:19016152030.013
Fly
positive regulation of mapk cascadeGO:00434101700.013
apoptotic signaling pathwayGO:00971903060.013
regulation of cytoplasmic transportGO:19036491120.012
toll like receptor signaling pathwayGO:0002224380.012
leukocyte proliferationGO:00706611720.012
Human
peptidyl tyrosine phosphorylationGO:00181081430.012
cell growthGO:00160491300.012
regulation of neuron projection developmentGO:00109751690.012
negative regulation of protein phosphorylationGO:00019331260.012
cytosolic calcium ion transportGO:0060401480.012
engulfment of apoptotic cellGO:004365230.012
positive regulation of nervous system developmentGO:00519622210.012
calcium ion transmembrane transportGO:0070588850.012
protein localization to membraneGO:00726571080.012
regulation of phagocytosisGO:0050764330.012
regulation of wnt signaling pathwayGO:00301111230.012
protein localization to organelleGO:00333651850.012
positive regulation of innate immune responseGO:0045089800.012
muscle cell differentiationGO:00426922610.012
glycosylationGO:0070085620.012
protein autophosphorylationGO:0046777610.012
multicellular organismal signalingGO:0035637910.012
cellular response to growth factor stimulusGO:00713631970.012
glucose homeostasisGO:00425931280.012
nuclear transportGO:00511691390.012
heart morphogenesisGO:00030071780.012
positive regulation of organelle organizationGO:00106381280.012
morphogenesis of a branching structureGO:00017632030.012
negative regulation of growthGO:0045926990.012
intracellular protein transportGO:00068862040.012
meiotic cell cycleGO:00513211220.012
blood coagulationGO:0007596760.012
respiratory tube developmentGO:00303231670.012
mitotic cytokinesisGO:000028140.012
mesodermal cell migrationGO:000807840.012
posttranscriptional regulation of gene expressionGO:00106081550.012
cellular response to organonitrogen compoundGO:00714171450.012
purine nucleoside monophosphate metabolic processGO:0009126810.012
response to organic cyclic compoundGO:00140701980.012
hemostasisGO:0007599780.012
nucleotide sugar metabolic processGO:000922540.012
negative regulation of b cell receptor signaling pathwayGO:005085940.012
regulation of mitotic cell cycleGO:00073461260.012
stem cell maintenanceGO:00198271300.012
negative regulation of phosphorus metabolic processGO:00105631840.012
regulation of t cell activationGO:00508631700.012
microtubule cytoskeleton organizationGO:00002261570.011
fatty acid metabolic processGO:00066311210.011
morphogenesis of a branching epitheliumGO:00611381930.011
rab protein signal transductionGO:003248210.011
proteolysis involved in cellular protein catabolic processGO:00516031470.011
dna repairGO:00062811070.011
neuron apoptotic processGO:00514021420.011
phospholipid metabolic processGO:0006644870.011
nucleoside monophosphate metabolic processGO:0009123850.011
erythrocyte differentiationGO:0030218880.011
sensory organ morphogenesisGO:00905962420.011
leukocyte mediated immunityGO:00024431740.011
regulation of system processGO:00440572000.011
protein localization to nucleusGO:00345041210.011
t cell differentiationGO:00302171740.011
development of primary sexual characteristicsGO:00451371430.011
stem cell developmentGO:00488642190.011
regulation of proteolysisGO:00301621640.011
positive regulation of immune effector processGO:00026991070.011
b 1 b cell differentiationGO:000192330.011
negative regulation of nik nf kappab signalingGO:190122320.011
positive regulation of rho gtpase activityGO:0032321410.011
Mouse Fly
regulation of protein catabolic processGO:00421761080.011
positive regulation of t cell activationGO:00508701010.011
regulation of leukocyte differentiationGO:19021051590.011
cellularizationGO:000734910.011
regulation of ion homeostasisGO:2000021640.011
vesicle localizationGO:0051648860.011
negative regulation of nervous system developmentGO:00519611560.011
ribonucleoside monophosphate metabolic processGO:0009161800.011
regulation of cell cycle processGO:00105641600.011
glycerophospholipid metabolic processGO:0006650710.011
myeloid leukocyte activationGO:0002274830.011
regulation of antigen receptor mediated signaling pathwayGO:0050854290.011
regulation of coagulationGO:0050818310.011
stem cell differentiationGO:00488632680.011
regulation of cell adhesionGO:00301551540.010
cellular divalent inorganic cation homeostasisGO:00725031270.010
activation of rac gtpase activityGO:003286320.010
chromatin organizationGO:00063252060.010
striated muscle tissue developmentGO:00147062930.010
actin filament polymerizationGO:0030041440.010
mitochondrion organizationGO:00070051340.010
protein polymerizationGO:0051258570.010
hematopoietic progenitor cell differentiationGO:00022441430.010
Mouse
nucleocytoplasmic transportGO:00069131390.010
positive regulation of actin nucleationGO:005112730.010
cellular response to extracellular stimulusGO:0031668810.010
toll like receptor 7 signaling pathwayGO:003415440.010
negative regulation of phagocytosisGO:005076540.010
negative regulation of toll like receptor 2 signaling pathwayGO:003413630.010
peptidyl tyrosine modificationGO:00182121450.010
myosin filament assemblyGO:003103420.010
negative regulation of neuron deathGO:1901215980.010
organic hydroxy compound transportGO:0015850930.010
axon guidanceGO:00074111410.010
regulation of protein transportGO:00512231630.010
regulation of lymphocyte proliferationGO:00506701170.010
regulation of transmembrane transportGO:00347621280.010
cellular response to dna damage stimulusGO:00069742070.010
methylationGO:00322591340.010
myotube differentiationGO:00149021050.010
skeletal system developmentGO:00015013560.010

Dock8 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of metabolismDOID:001466700.026
disease of anatomical entityDOID:700.026
nervous system diseaseDOID:86300.026
central nervous system diseaseDOID:33100.023
inherited metabolic disorderDOID:65500.020
cancerDOID:16200.018
organ system cancerDOID:005068600.018
disease of cellular proliferationDOID:1456600.018
immune system diseaseDOID:291400.018
sensory system diseaseDOID:005015500.015
eye and adnexa diseaseDOID:149200.011
eye diseaseDOID:561400.011