Mus musculus

54 known processes

Pdk1

pyruvate dehydrogenase kinase, isoenzyme 1

(Aliases: B830012B01,D530020C15Rik)

Pdk1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
monocarboxylic acid metabolic processGO:00327871910.095
organic cyclic compound catabolic processGO:19013612950.073
nucleoside phosphate metabolic processGO:00067533380.062
nucleotide metabolic processGO:00091173320.062
macromolecule catabolic processGO:00090572810.057
purine containing compound metabolic processGO:00725213110.057
cellular amino acid metabolic processGO:00065201030.056
nucleobase containing small molecule metabolic processGO:00550863520.054
aromatic compound catabolic processGO:00194392860.054
oxidation reduction processGO:00551143420.050
ribonucleotide metabolic processGO:00092592910.049
cellular amine metabolic processGO:0044106440.049
cellular ketone metabolic processGO:0042180840.047
glycosyl compound metabolic processGO:19016572460.046
amine metabolic processGO:0009308450.046
cellular nitrogen compound catabolic processGO:00442702800.045
regulation of cellular ketone metabolic processGO:0010565660.045
mitochondrion organizationGO:00070051340.044
coenzyme metabolic processGO:0006732520.044
cellular lipid metabolic processGO:00442553230.043
purine nucleoside metabolic processGO:00422782410.043
regulation of cellular amine metabolic processGO:0033238200.042
purine nucleoside triphosphate metabolic processGO:00091442260.041
nucleoside metabolic processGO:00091162460.041
regulation of cellular amino acid metabolic processGO:000652150.040
heterocycle catabolic processGO:00467002800.040
cellular macromolecule catabolic processGO:00442652060.039
coenzyme biosynthetic processGO:0009108230.038
purine ribonucleotide metabolic processGO:00091502900.037
organonitrogen compound catabolic processGO:19015652640.037
purine nucleotide metabolic processGO:00061633020.035
apoptotic signaling pathwayGO:00971903060.034
Human
positive regulation of cellular amino acid metabolic processGO:004576430.034
regulation of membrane potentialGO:00423911920.033
carbohydrate metabolic processGO:00059752300.031
Human Mouse
nucleoside phosphate catabolic processGO:19012922220.031
carbohydrate derivative catabolic processGO:19011362310.031
positive regulation of cellular amine metabolic processGO:003324050.031
small gtpase mediated signal transductionGO:0007264970.030
organophosphate catabolic processGO:00464342320.030
transmembrane transportGO:00550854120.030
regulation of mitochondrial fissionGO:009014030.029
dna metabolic processGO:00062593030.029
ribonucleoside metabolic processGO:00091192450.029
cell type specific apoptotic processGO:00972852680.029
purine ribonucleoside metabolic processGO:00461282410.028
small molecule biosynthetic processGO:00442831320.028
negative regulation of cellular protein metabolic processGO:00322692470.028
nucleotide catabolic processGO:00091662170.027
positive regulation of apoptotic processGO:00430652170.027
nucleoside triphosphate metabolic processGO:00091412300.027
purine containing compound catabolic processGO:00725232130.027
cytoplasmic transportGO:00164822340.026
immune effector processGO:00022523210.026
positive regulation of cell deathGO:00109422240.026
purine ribonucleotide catabolic processGO:00091542080.026
cofactor metabolic processGO:0051186800.026
intracellular protein transportGO:00068862040.026
regulation of cytokine productionGO:00018172660.026
organonitrogen compound biosynthetic processGO:19015661920.026
reactive oxygen species metabolic processGO:0072593840.026
ribonucleoside triphosphate catabolic processGO:00092031990.026
regulation of organelle organizationGO:00330432890.025
regulation of protein kinase activityGO:00458592320.025
negative regulation of protein metabolic processGO:00512482820.025
cytokine productionGO:00018163190.025
ribonucleoside triphosphate metabolic processGO:00091992200.025
ribose phosphate metabolic processGO:00196932910.025
regulation of kinase activityGO:00435492490.025
response to inorganic substanceGO:0010035960.024
purine ribonucleoside triphosphate metabolic processGO:00092052200.024
homeostasis of number of cellsGO:00488722100.024
protein catabolic processGO:00301632210.023
purine nucleotide catabolic processGO:00061952110.023
regulation of apoptotic signaling pathwayGO:20012331970.023
cellular protein catabolic processGO:00442571550.023
fat cell differentiationGO:00454441600.023
regulation of hydrolase activityGO:00513362460.022
negative regulation of phosphate metabolic processGO:00459361840.022
positive regulation of protein modification processGO:00314012990.022
response to nutrient levelsGO:00316671090.022
Mouse
purine nucleoside catabolic processGO:00061522050.022
cofactor biosynthetic processGO:0051188410.022
regulation of mapk cascadeGO:00434082480.021
regulation of protein localizationGO:00328802310.021
response to organonitrogen compoundGO:00102432460.021
Mouse
positive regulation of mitochondrion organizationGO:0010822170.020
lipid biosynthetic processGO:00086101790.020
ribonucleoside monophosphate metabolic processGO:0009161800.020
cellular carbohydrate metabolic processGO:00442621190.020
Human Mouse
leukocyte differentiationGO:00025213420.020
regulation of cellular catabolic processGO:00313292420.020
male gamete generationGO:00482322850.020
intrinsic apoptotic signaling pathwayGO:00971931320.020
Human
cellular response to external stimulusGO:0071496880.020
Mouse
purine ribonucleoside catabolic processGO:00461302050.019
peptidyl amino acid modificationGO:00181933360.019
Rat
defense response to other organismGO:00985421970.019
response to organic cyclic compoundGO:00140701980.019
regulation of transferase activityGO:00513382630.019
positive regulation of organelle organizationGO:00106381280.019
negative regulation of phosphorus metabolic processGO:00105631840.019
purine nucleoside triphosphate catabolic processGO:00091462030.019
ribonucleotide catabolic processGO:00092612080.019
response to oxidative stressGO:00069791230.019
Human
negative regulation of immune system processGO:00026832090.019
protein modification by small protein conjugation or removalGO:00706472070.019
positive regulation of programmed cell deathGO:00430682180.019
organophosphate biosynthetic processGO:00904071220.019
nitrogen compound transportGO:00717052710.019
ossificationGO:00015032160.019
generation of precursor metabolites and energyGO:00060911030.018
apoptotic mitochondrial changesGO:0008637480.018
t cell activationGO:00421102890.018
regulation of cell activationGO:00508652890.018
purine ribonucleoside triphosphate catabolic processGO:00092071990.018
protein maturationGO:00516041760.018
response to lipopolysaccharideGO:00324961280.018
glycerolipid metabolic processGO:00464861220.018
nucleoside triphosphate catabolic processGO:00091432050.018
anion transportGO:00068201770.018
ribonucleoside catabolic processGO:00424542060.018
action potentialGO:0001508780.018
rhythmic processGO:00485111740.018
nucleoside catabolic processGO:00091642060.018
histone modificationGO:00165701590.018
mapk cascadeGO:00001652810.018
negative regulation of cellular component organizationGO:00511291940.017
negative regulation of apoptotic signaling pathwayGO:20012341040.017
response to molecule of bacterial originGO:00022371430.017
regulation of lymphocyte activationGO:00512492400.017
myeloid cell differentiationGO:00300992330.017
cellular component assembly involved in morphogenesisGO:00109271390.017
sensory perceptionGO:00076002450.017
purine ribonucleoside monophosphate metabolic processGO:0009167800.017
respiratory system developmentGO:00605411900.017
spermatogenesisGO:00072832840.017
carbohydrate derivative biosynthetic processGO:19011371830.017
negative regulation of cellular amine metabolic processGO:003323910.017
fatty acid metabolic processGO:00066311210.017
synaptic transmissionGO:00072683290.017
neuron apoptotic processGO:00514021420.016
cellular response to growth factor stimulusGO:00713631970.016
regulation of t cell activationGO:00508631700.016
regulation of secretionGO:00510462740.016
regulation of secretion by cellGO:19035302490.016
translationGO:0006412930.016
organelle fissionGO:00482851700.016
transmission of nerve impulseGO:0019226760.016
cellular homeostasisGO:00197252400.016
carboxylic acid catabolic processGO:0046395510.016
membrane organizationGO:00610242450.016
chromatin organizationGO:00063252060.016
blood circulationGO:00080151950.016
protein ubiquitinationGO:00165671710.016
modification dependent macromolecule catabolic processGO:00436321330.016
carboxylic acid biosynthetic processGO:0046394860.016
protein modification by small protein conjugationGO:00324461870.016
glycosyl compound catabolic processGO:19016582060.015
sulfur compound metabolic processGO:00067901000.015
negative regulation of protein modification processGO:00314001630.015
negative regulation of cellular amino acid metabolic processGO:004576300.015
organic hydroxy compound metabolic processGO:19016152030.015
small molecule catabolic processGO:0044282710.015
hematopoietic progenitor cell differentiationGO:00022441430.015
protein processingGO:00164851630.015
striated muscle tissue developmentGO:00147062930.015
lipid catabolic processGO:0016042690.015
atp metabolic processGO:0046034750.015
positive regulation of protein phosphorylationGO:00019342420.015
gland developmentGO:00487323300.015
release of cytochrome c from mitochondriaGO:0001836230.015
multicellular organismal signalingGO:0035637910.015
nucleotide biosynthetic processGO:0009165780.015
posttranscriptional regulation of gene expressionGO:00106081550.015
protein targetingGO:00066051430.015
maintenance of locationGO:0051235890.014
innate immune responseGO:00450871570.014
ion transmembrane transportGO:00342203610.014
neuron deathGO:00709971540.014
forebrain developmentGO:00309003020.014
cellular response to dna damage stimulusGO:00069742070.014
negative regulation of cell proliferationGO:00082852960.014
cellular response to lipidGO:00713961450.014
circulatory system processGO:00030131970.014
positive regulation of apoptotic signaling pathwayGO:2001235950.014
skeletal system developmentGO:00015013560.014
ras protein signal transductionGO:0007265770.014
cation transportGO:00068123990.014
cellular response to organonitrogen compoundGO:00714171450.014
Mouse
regulation of establishment of protein localizationGO:00702011810.014
regulation of mitochondrion organizationGO:0010821270.014
energy derivation by oxidation of organic compoundsGO:0015980770.014
lung developmentGO:00303241640.014
regulation of nucleotide metabolic processGO:00061401690.014
chromatin modificationGO:00165681870.014
cation transmembrane transportGO:00986552660.014
regulation of defense responseGO:00313472330.013
nuclear transportGO:00511691390.013
tube formationGO:00351481400.013
organic anion transportGO:00157111370.013
defense response to virusGO:0051607680.013
nucleocytoplasmic transportGO:00069131390.013
gtp metabolic processGO:00460391440.013
nucleoside phosphate biosynthetic processGO:1901293790.013
lymphocyte proliferationGO:00466511640.013
regulation of hormone levelsGO:00108172110.013
skin developmentGO:00435882200.013
hexose metabolic processGO:0019318980.013
Human Mouse
g protein coupled receptor signaling pathwayGO:00071862430.013
purine nucleoside monophosphate metabolic processGO:0009126810.013
microtubule based processGO:00070172360.013
stem cell differentiationGO:00488632680.013
asymmetric stem cell divisionGO:009872230.013
cellular glucan metabolic processGO:0006073320.013
granzyme mediated apoptotic signaling pathwayGO:000862610.013
response to extracellular stimulusGO:00099911270.013
Mouse
acetate metabolic processGO:000608310.013
alpha amino acid metabolic processGO:1901605590.013
regulation of protein serine threonine kinase activityGO:00719001570.013
meiosis iGO:0007127600.013
monocarboxylic acid biosynthetic processGO:0072330610.013
positive regulation of mapk cascadeGO:00434101700.013
nucleoside monophosphate metabolic processGO:0009123850.013
gtp catabolic processGO:00061841430.013
cellular protein complex assemblyGO:00436231160.013
negative regulation of phosphorylationGO:00423261660.013
regulation of reactive oxygen species metabolic processGO:2000377400.013
response to growth factorGO:00708481980.013
cation homeostasisGO:00550802120.013
Mouse
monosaccharide metabolic processGO:00059961060.012
Human Mouse
negative regulation of membrane potentialGO:004583740.012
lipid localizationGO:00108761260.012
regulation of cellular component biogenesisGO:00440871810.012
positive regulation of kinase activityGO:00336741550.012
multicellular organismal homeostasisGO:00488711640.012
respiratory tube developmentGO:00303231670.012
positive regulation of cell developmentGO:00107202370.012
regulation of purine nucleotide metabolic processGO:19005421690.012
negative regulation of organelle organizationGO:0010639900.012
organelle localizationGO:00516401790.012
negative regulation of intracellular signal transductionGO:19025321670.012
alcohol metabolic processGO:00060661160.012
neuronal action potentialGO:0019228540.012
germ cell developmentGO:00072811850.012
epithelial tube morphogenesisGO:00605623030.012
cellular response to hormone stimulusGO:00328701500.012
Mouse
endomembrane system organizationGO:00102561470.012
rho protein signal transductionGO:0007266320.012
organic acid biosynthetic processGO:0016053860.012
positive regulation of release of cytochrome c from mitochondriaGO:009020050.012
plasma membrane organizationGO:0007009900.012
dephosphorylationGO:00163111290.012
glucose homeostasisGO:00425931280.012
Mouse
glucose metabolic processGO:0006006920.012
Human Mouse
negative regulation of molecular functionGO:00440922580.012
cellular lipid catabolic processGO:0044242520.012
protein localization to membraneGO:00726571080.012
cellular chemical homeostasisGO:00550822150.012
blood vessel morphogenesisGO:00485142850.012
regionalizationGO:00030023370.012
anion transmembrane transportGO:0098656710.012
regulation of cellular response to stressGO:00801351590.012
response to peptideGO:19016521360.012
Mouse
regulation of synaptic growth at neuromuscular junctionGO:000858240.012
anatomical structure homeostasisGO:00602491450.012
lipid transportGO:0006869980.012
morphogenesis of embryonic epitheliumGO:00163311590.011
carbohydrate homeostasisGO:00335001280.011
Mouse
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071692470.011
Mouse
positive regulation of defense responseGO:00313491240.011
lymphocyte differentiationGO:00300982420.011
regulation of response to woundingGO:19030341890.011
muscle cell differentiationGO:00426922610.011
embryonic epithelial tube formationGO:00018381300.011
kidney developmentGO:00018222130.011
leukocyte proliferationGO:00706611720.011
cellular response to inorganic substanceGO:0071241370.011
response to acid chemicalGO:00011011110.011
locomotory behaviorGO:00076261950.011
acylglycerol metabolic processGO:0006639550.011
muscle tissue developmentGO:00605373080.011
developmental maturationGO:00217001930.011
organic acid catabolic processGO:0016054510.011
cellular metal ion homeostasisGO:00068751510.011
inflammatory responseGO:00069542440.011
compound eye developmentGO:004874910.011
leukocyte homeostasisGO:0001776790.011
renal system developmentGO:00720012250.011
regulation of cell cycleGO:00517262810.011
guanosine containing compound metabolic processGO:19010681440.011
urogenital system developmentGO:00016552610.011
lipid homeostasisGO:0055088630.011
cell fate commitmentGO:00451652100.011
carbohydrate biosynthetic processGO:0016051740.011
Mouse
response to metal ionGO:0010038470.011
multicellular organism growthGO:00352641610.011
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781940.011
carbohydrate catabolic processGO:0016052320.011
carboxylic acid transportGO:00469421000.011
inorganic cation transmembrane transportGO:00986622070.011
regulation of leukocyte proliferationGO:00706631210.011
response to oxygen levelsGO:0070482620.011
Human
organic acid transportGO:00158491010.011
regulation of cell motilityGO:20001452360.011
response to steroid hormoneGO:0048545560.011
meiotic nuclear divisionGO:00071261150.011
brown fat cell differentiationGO:0050873360.011
microtubule based movementGO:0007018840.010
circadian rhythmGO:00076231140.010
tissue homeostasisGO:00018941150.010
pirna metabolic processGO:0034587120.010
camera type eye developmentGO:00430102660.010
regulation of translationGO:0006417710.010
skeletal system morphogenesisGO:00487052030.010
myeloid leukocyte differentiationGO:00025731190.010
sequestering of calcium ionGO:0051208180.010
heart morphogenesisGO:00030071780.010
triglyceride metabolic processGO:0006641510.010
regulation of lymphocyte proliferationGO:00506701170.010
protein localization to plasma membraneGO:0072659570.010
positive regulation of cell activationGO:00508671580.010
response to radiationGO:00093141650.010
cellular alcohol biosynthetic processGO:004410830.010
positive regulation of hydrolase activityGO:00513451480.010
cellular response to cytokine stimulusGO:00713451890.010
extrinsic apoptotic signaling pathwayGO:00971911260.010
placenta developmentGO:00018901400.010
regulation of leukocyte apoptotic processGO:2000106560.010
steroid metabolic processGO:00082021190.010
axonogenesisGO:00074092740.010
mitochondrial transportGO:0006839360.010
lymphocyte apoptotic processGO:0070227540.010
positive regulation of innate immune responseGO:0045089800.010
regulation of system processGO:00440572000.010
mitochondrial membrane organizationGO:0007006260.010

Pdk1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of metabolismDOID:001466700.027
inherited metabolic disorderDOID:65500.022
disease of anatomical entityDOID:700.015
musculoskeletal system diseaseDOID:1700.015
nervous system diseaseDOID:86300.014
amino acid metabolic disorderDOID:925200.012
disease of cellular proliferationDOID:1456600.012
cardiovascular system diseaseDOID:128700.011
central nervous system diseaseDOID:33100.011