Mus musculus

133 known processes

Pdk4

pyruvate dehydrogenase kinase, isoenzyme 4

(Aliases: AV005916)

Pdk4 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
oxidation reduction processGO:00551143420.208
cofactor metabolic processGO:0051186800.144
monocarboxylic acid metabolic processGO:00327871910.134
long chain fatty acid importGO:004453920.126
cellular lipid metabolic processGO:00442553230.125
cellular ketone metabolic processGO:0042180840.122
cellular lipid catabolic processGO:0044242520.117
cellular amine metabolic processGO:0044106440.117
fatty acid metabolic processGO:00066311210.116
amine metabolic processGO:0009308450.113
cellular amino acid metabolic processGO:00065201030.112
transmembrane transportGO:00550854120.086
small molecule catabolic processGO:0044282710.085
lipid catabolic processGO:0016042690.082
cation transportGO:00068123990.082
regulation of cellular amine metabolic processGO:0033238200.079
carbohydrate metabolic processGO:00059752300.076
organic anion transportGO:00157111370.070
cellular response to organonitrogen compoundGO:00714171450.069
negative regulation of molecular functionGO:00440922580.066
organonitrogen compound catabolic processGO:19015652640.065
lipid biosynthetic processGO:00086101790.065
regulation of cellular ketone metabolic processGO:0010565660.064
response to oxidative stressGO:00069791230.064
acylglycerol metabolic processGO:0006639550.063
response to organonitrogen compoundGO:00102432460.063
negative regulation of protein metabolic processGO:00512482820.063
negative regulation of phosphorus metabolic processGO:00105631840.062
sterol homeostasisGO:0055092450.062
lipid transportGO:0006869980.061
glycerolipid metabolic processGO:00464861220.060
lipid modificationGO:0030258650.060
regulation of cellular amino acid metabolic processGO:000652150.058
organic hydroxy compound metabolic processGO:19016152030.056
nucleoside phosphate metabolic processGO:00067533380.055
regulation of fatty acid oxidationGO:0046320100.052
anion transportGO:00068201770.052
ion transmembrane transportGO:00342203610.052
triglyceride metabolic processGO:0006641510.051
nucleotide metabolic processGO:00091173320.049
neutral lipid metabolic processGO:0006638570.048
cholesterol homeostasisGO:0042632440.048
maintenance of locationGO:0051235890.048
lipid homeostasisGO:0055088630.048
cytokine productionGO:00018163190.044
response to hypoxiaGO:0001666580.043
lipid oxidationGO:0034440290.043
response to organic cyclic compoundGO:00140701980.043
pyridine nucleotide catabolic processGO:001936430.042
peptidyl amino acid modificationGO:00181933360.042
nucleobase containing small molecule metabolic processGO:00550863520.042
response to oxygen levelsGO:0070482620.042
cation transmembrane transportGO:00986552660.042
heterocycle catabolic processGO:00467002800.041
negative regulation of protein phosphorylationGO:00019331260.041
cellular nitrogen compound catabolic processGO:00442702800.040
negative regulation of cellular protein metabolic processGO:00322692470.039
cellular response to oxidative stressGO:0034599760.039
lipid localizationGO:00108761260.039
reactive oxygen species metabolic processGO:0072593840.039
positive regulation of cell deathGO:00109422240.038
negative regulation of phosphorylationGO:00423261660.038
regulation of apoptotic signaling pathwayGO:20012331970.038
cellular response to hormone stimulusGO:00328701500.037
fat cell differentiationGO:00454441600.037
organic acid transportGO:00158491010.037
organic cyclic compound catabolic processGO:19013612950.036
inorganic cation transmembrane transportGO:00986622070.036
carboxylic acid transportGO:00469421000.036
negative regulation of phosphate metabolic processGO:00459361840.036
apoptotic signaling pathwayGO:00971903060.036
muscle system processGO:00030121410.036
organophosphate catabolic processGO:00464342320.036
negative regulation of protein modification processGO:00314001630.036
aromatic compound catabolic processGO:00194392860.035
response to peptideGO:19016521360.035
multicellular organismal signalingGO:0035637910.034
positive regulation of cellular amine metabolic processGO:003324050.034
regulation of membrane potentialGO:00423911920.034
positive regulation of cellular amino acid metabolic processGO:004576430.034
fatty acid oxidationGO:0019395280.034
regulation of cellular catabolic processGO:00313292420.033
glycerolipid biosynthetic processGO:0045017500.033
response to radiationGO:00093141650.032
response to lipopolysaccharideGO:00324961280.032
macromolecule catabolic processGO:00090572810.031
positive regulation of apoptotic processGO:00430652170.031
brown fat cell differentiationGO:0050873360.031
regulation of transferase activityGO:00513382630.031
energy derivation by oxidation of organic compoundsGO:0015980770.031
muscle tissue developmentGO:00605373080.031
circulatory system processGO:00030131970.030
cellular ion homeostasisGO:00068731650.030
ribonucleotide metabolic processGO:00092592910.030
response to peptide hormoneGO:00434341270.030
response to inorganic substanceGO:0010035960.029
ribose phosphate metabolic processGO:00196932910.029
alcohol metabolic processGO:00060661160.029
purine containing compound metabolic processGO:00725213110.029
regulation of lipid metabolic processGO:00192161180.029
regulation of hydrolase activityGO:00513362460.029
negative regulation of transferase activityGO:0051348850.029
g protein coupled receptor signaling pathwayGO:00071862430.029
heart contractionGO:0060047930.028
cellular homeostasisGO:00197252400.028
response to decreased oxygen levelsGO:0036293590.028
cholesterol metabolic processGO:0008203560.028
organophosphate biosynthetic processGO:00904071220.028
coenzyme metabolic processGO:0006732520.028
inflammatory responseGO:00069542440.028
camera type eye developmentGO:00430102660.027
blood circulationGO:00080151950.027
purine nucleotide metabolic processGO:00061633020.027
response to drugGO:0042493750.027
negative regulation of intracellular signal transductionGO:19025321670.027
regulation of hormone levelsGO:00108172110.026
regulation of leukocyte differentiationGO:19021051590.026
carboxylic acid catabolic processGO:0046395510.026
regulation of kinase activityGO:00435492490.026
glycerophospholipid metabolic processGO:0006650710.026
sterol metabolic processGO:0016125580.026
regulation of system processGO:00440572000.026
regulation of cytokine productionGO:00018172660.026
cholesterol storageGO:001087840.026
regulation of homeostatic processGO:00328441820.025
purine containing compound catabolic processGO:00725232130.025
response to molecule of bacterial originGO:00022371430.025
nucleotide catabolic processGO:00091662170.025
steroid metabolic processGO:00082021190.025
monocarboxylic acid transportGO:0015718440.025
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781940.025
intrinsic apoptotic signaling pathwayGO:00971931320.025
cell adhesionGO:00071553290.025
positive regulation of programmed cell deathGO:00430682180.024
t cell activationGO:00421102890.024
negative regulation of kinase activityGO:0033673810.024
skeletal muscle organ developmentGO:00605381630.024
positive regulation of protein modification processGO:00314012990.024
striated muscle tissue developmentGO:00147062930.024
sulfur compound metabolic processGO:00067901000.024
protein maturationGO:00516041760.024
cation homeostasisGO:00550802120.024
second messenger mediated signalingGO:0019932730.024
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071692470.024
generation of precursor metabolites and energyGO:00060911030.024
monosaccharide metabolic processGO:00059961060.023
regulation of mapk cascadeGO:00434082480.023
regulation of ion transmembrane transportGO:00347651190.023
regulation of ion transportGO:00432692150.023
long chain fatty acid metabolic processGO:0001676260.023
monocarboxylic acid catabolic processGO:0072329270.022
multicellular organismal homeostasisGO:00488711640.022
cellular response to peptideGO:1901653920.022
myeloid cell differentiationGO:00300992330.022
response to acid chemicalGO:00011011110.022
spermatogenesisGO:00072832840.022
negative regulation of hydrolase activityGO:0051346710.022
response to insulinGO:00328681000.022
regulation of lipid biosynthetic processGO:0046890540.022
regulation of phospholipid biosynthetic processGO:007107130.022
protein catabolic processGO:00301632210.022
regulation of cell projection organizationGO:00313442060.022
negative regulation of cellular amino acid metabolic processGO:004576300.022
isoprenoid metabolic processGO:0006720290.022
regulation of cell activationGO:00508652890.021
regulation of protein serine threonine kinase activityGO:00719001570.021
organonitrogen compound biosynthetic processGO:19015661920.021
purine nucleoside triphosphate metabolic processGO:00091442260.021
mitochondrion organizationGO:00070051340.021
purine ribonucleotide metabolic processGO:00091502900.021
membrane organizationGO:00610242450.021
purine ribonucleoside triphosphate metabolic processGO:00092052200.021
nucleoside phosphate catabolic processGO:19012922220.021
carbohydrate derivative biosynthetic processGO:19011371830.021
blood vessel morphogenesisGO:00485142850.021
glycosyl compound metabolic processGO:19016572460.021
cellular carbohydrate metabolic processGO:00442621190.021
hexose metabolic processGO:0019318980.021
response to steroid hormoneGO:0048545560.021
cellular chemical homeostasisGO:00550822150.021
regulation of anatomical structure sizeGO:00900661780.021
long chain fatty acid transportGO:0015909150.021
ribonucleoside metabolic processGO:00091192450.021
negative regulation of cellular amine metabolic processGO:003323910.021
protein processingGO:00164851630.020
ribonucleotide catabolic processGO:00092612080.020
regulation of establishment of protein localizationGO:00702011810.020
positive regulation of cell developmentGO:00107202370.020
response to nutrient levelsGO:00316671090.020
male gamete generationGO:00482322850.020
forebrain developmentGO:00309003020.020
nitrogen compound transportGO:00717052710.020
nucleoside metabolic processGO:00091162460.020
muscle contractionGO:00069361010.020
nucleoside triphosphate metabolic processGO:00091412300.020
cell type specific apoptotic processGO:00972852680.020
regulation of neuron differentiationGO:00456642810.020
muscle cell differentiationGO:00426922610.020
diterpenoid metabolic processGO:0016101240.020
locomotory behaviorGO:00076261950.019
negative regulation of phospholipase activityGO:001051940.019
immune effector processGO:00022523210.019
purine ribonucleotide catabolic processGO:00091542080.019
lipid storageGO:0019915360.019
regulation of cell cycleGO:00517262810.019
ribonucleoside triphosphate metabolic processGO:00091992200.019
inorganic ion transmembrane transportGO:00986602340.019
cellular response to biotic stimulusGO:0071216920.019
purine nucleoside metabolic processGO:00422782410.019
nucleoside catabolic processGO:00091642060.019
multi multicellular organism processGO:00447061090.019
cytoplasmic transportGO:00164822340.019
positive regulation of fatty acid oxidationGO:004632140.019
regulation of carbohydrate metabolic processGO:0006109750.019
protein modification by small protein conjugation or removalGO:00706472070.019
neuronal action potentialGO:0019228540.019
positive regulation of macrophage derived foam cell differentiationGO:001074440.019
heart processGO:0003015940.019
monocarboxylic acid biosynthetic processGO:0072330610.018
regulation of blood pressureGO:0008217930.018
glucose metabolic processGO:0006006920.018
small gtpase mediated signal transductionGO:0007264970.018
protein oligomerizationGO:0051259670.018
homeostasis of number of cellsGO:00488722100.018
response to light stimulusGO:00094161350.018
innate immune responseGO:00450871570.018
very long chain fatty acid catabolic processGO:004276020.018
purine nucleoside catabolic processGO:00061522050.018
phospholipid metabolic processGO:0006644870.018
cellular macromolecule catabolic processGO:00442652060.018
negative regulation of oxidative stress induced intrinsic apoptotic signaling pathwayGO:190217640.018
regulation of defense responseGO:00313472330.018
regulation of triglyceride biosynthetic processGO:0010866100.018
leukocyte differentiationGO:00025213420.017
cellular response to peptide hormone stimulusGO:0071375920.017
divalent metal ion transportGO:00708381720.017
protein localization to organelleGO:00333651850.017
regulation of organelle organizationGO:00330432890.017
protein localization to nucleusGO:00345041210.017
organic acid catabolic processGO:0016054510.017
purine ribonucleoside catabolic processGO:00461302050.017
anion transmembrane transportGO:0098656710.017
purine ribonucleoside metabolic processGO:00461282410.017
cellular response to insulin stimulusGO:0032869780.017
cofactor catabolic processGO:005118760.017
regulation of phosphatidylcholine catabolic processGO:001089920.017
developmental growth involved in morphogenesisGO:00605601380.017
ras protein signal transductionGO:0007265770.017
cellular biogenic amine metabolic processGO:0006576280.017
metal ion homeostasisGO:00550651890.017
regulation of glucose metabolic processGO:0010906600.016
sodium ion transportGO:0006814730.016
purine nucleotide catabolic processGO:00061952110.016
retinoid metabolic processGO:0001523240.016
divalent inorganic cation homeostasisGO:00725071380.016
coenzyme catabolic processGO:000910950.016
regulation of protein kinase activityGO:00458592320.016
negative regulation of apoptotic signaling pathwayGO:20012341040.016
cellular response to organic cyclic compoundGO:0071407870.016
divalent inorganic cation transportGO:00725111780.016
calcium ion transportGO:00068161590.016
mapk cascadeGO:00001652810.016
protein modification by small protein conjugationGO:00324461870.016
regulation of peptidase activityGO:0052547960.016
telencephalon developmentGO:00215371860.016
anatomical structure homeostasisGO:00602491450.016
carbohydrate biosynthetic processGO:0016051740.016
Mouse
ribonucleoside triphosphate catabolic processGO:00092031990.016
ribonucleoside catabolic processGO:00424542060.016
fat soluble vitamin biosynthetic processGO:004236240.016
reactive nitrogen species metabolic processGO:200105700.015
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:00900921120.015
cellular response to dna damage stimulusGO:00069742070.015
regulation of cellular response to stressGO:00801351590.015
regulation of cellular carbohydrate metabolic processGO:0010675750.015
regulation of phosphatidylcholine biosynthetic processGO:200124520.015
cellular response to cytokine stimulusGO:00713451890.015
carbohydrate derivative catabolic processGO:19011362310.015
actin filament organizationGO:00070151130.015
ossificationGO:00015032160.015
endomembrane system organizationGO:00102561470.015
regulation of secretionGO:00510462740.015
multicellular organism growthGO:00352641610.015
regulation of protein transportGO:00512231630.015
regulation of inflammatory responseGO:00507271470.015
actin cytoskeleton organizationGO:00300362200.015
action potentialGO:0001508780.015
regulation of cell motilityGO:20001452360.015
regulation of protein localizationGO:00328802310.015
organic acid biosynthetic processGO:0016053860.015
regulation of response to woundingGO:19030341890.015
regulation of muscle system processGO:0090257800.015
kidney developmentGO:00018222130.015
sensory perceptionGO:00076002450.015
regulation of lymphocyte activationGO:00512492400.015
urogenital system developmentGO:00016552610.015
sensory organ morphogenesisGO:00905962420.014
positive regulation of cytokine productionGO:00018191740.014
retina development in camera type eyeGO:00600411190.014
terpenoid metabolic processGO:0006721250.014
purine nucleoside triphosphate catabolic processGO:00091462030.014
circadian regulation of gene expressionGO:0032922480.014
posttranscriptional regulation of gene expressionGO:00106081550.014
axonogenesisGO:00074092740.014
cellular response to molecule of bacterial originGO:0071219830.014
ribonucleoside monophosphate metabolic processGO:0009161800.014
striated muscle contractionGO:0006941450.014
fatty acid transportGO:0015908280.014
triglyceride biosynthetic processGO:0019432170.014
positive regulation of protein phosphorylationGO:00019342420.014
negative regulation of immune system processGO:00026832090.014
actin filament based movementGO:0030048230.014
purine ribonucleoside triphosphate catabolic processGO:00092071990.014
regulation of transmembrane transportGO:00347621280.014
protein ubiquitinationGO:00165671710.014
regulation of proteolysisGO:00301621640.014
regulation of cell growthGO:0001558910.014
positive regulation of growthGO:00459271040.014
cellular response to lipidGO:00713961450.014
cardiac muscle contractionGO:0060048320.014
regulation of reactive oxygen species metabolic processGO:2000377400.014
purine nucleoside monophosphate metabolic processGO:0009126810.014
organic hydroxy compound transportGO:0015850930.014
potassium ion transportGO:0006813520.014
glycoprotein metabolic processGO:00091001160.014
hexose transportGO:0008645560.014
respiratory system developmentGO:00605411900.014
response to mineralocorticoidGO:005138510.014
response to vitamin aGO:003318910.014
cellular response to lipopolysaccharideGO:0071222770.014
dephosphorylationGO:00163111290.013
microtubule based processGO:00070172360.013
epithelial cell developmentGO:00020641590.013
small molecule biosynthetic processGO:00442831320.013
response to extracellular stimulusGO:00099911270.013
defense response to other organismGO:00985421970.013
regulation of cellular component biogenesisGO:00440871810.013
glycerolipid catabolic processGO:0046503160.013
positive regulation of nervous system developmentGO:00519622210.013
monosaccharide transportGO:0015749580.013
rna interferenceGO:001624620.013
cellular response to inorganic substanceGO:0071241370.013
nucleocytoplasmic transportGO:00069131390.013
transmission of nerve impulseGO:0019226760.013
cellular amide metabolic processGO:0043603580.013
embryonic organ morphogenesisGO:00485622760.013
cellular response to growth factor stimulusGO:00713631970.013
cellular calcium ion homeostasisGO:00068741190.013
sequestering of calcium ionGO:0051208180.013
thioester metabolic processGO:0035383190.013
regulation of body fluid levelsGO:00508781620.013
mitotic cell cycle processGO:19030471590.013
regulation of myeloid cell differentiationGO:0045637960.013
renal system developmentGO:00720012250.013
fatty acid catabolic processGO:0009062250.013
fatty acid transmembrane transportGO:190200110.013
regulation of protein maturationGO:1903317960.013
response to epidermal growth factorGO:007084940.013
regulation of heart contractionGO:0008016770.013
compound eye developmentGO:004874910.013
carbohydrate transportGO:0008643620.013
intracellular protein transportGO:00068862040.013
positive regulation of cardiac muscle contractionGO:006045220.013
glycosylationGO:0070085620.013
positive regulation of cellular catabolic processGO:00313311480.013
regulation of intrinsic apoptotic signaling pathwayGO:2001242610.013
glycosyl compound catabolic processGO:19016582060.013
regulation of endopeptidase activityGO:0052548890.013
appendage developmentGO:00487361660.013
purine ribonucleoside monophosphate metabolic processGO:0009167800.013
cell growthGO:00160491300.013
epidermis developmentGO:00085441870.013
regulation of multi organism processGO:00439001110.013
rhythmic processGO:00485111740.013
regulation of secretion by cellGO:19035302490.013
acetate metabolic processGO:000608310.013
dna metabolic processGO:00062593030.013
nucleoside triphosphate catabolic processGO:00091432050.012
protein glycosylationGO:0006486550.012
mitotic cell cycleGO:00002781950.012
regulation of cell morphogenesis involved in differentiationGO:00107691510.012
negative regulation of cellular component organizationGO:00511291940.012
peptidyl tyrosine modificationGO:00182121450.012
response to starvationGO:0042594650.012
sequestering of metal ionGO:0051238190.012
wound healingGO:00420601570.012
synaptic transmissionGO:00072683290.012
calcium ion transmembrane transportGO:0070588850.012
i kappab kinase nf kappab signalingGO:0007249850.012
blood coagulationGO:0007596760.012
potassium ion transmembrane transportGO:0071805430.012
fertilizationGO:00095661270.012
glycogen metabolic processGO:0005977320.012
morphogenesis of a branching structureGO:00017632030.012
negative regulation of cell proliferationGO:00082852960.012
macromolecule glycosylationGO:0043413550.012
neuron deathGO:00709971540.012
regulation of feeding behaviorGO:006025930.012
adiponectin activated signaling pathwayGO:003321140.012
endocytosisGO:00068971680.012
cellular protein complex assemblyGO:00436231160.012
ameboidal type cell migrationGO:00016671280.012
germ cell developmentGO:00072811850.011
response to growth factorGO:00708481980.011
meiotic cell cycleGO:00513211220.011
positive regulation of hydrolase activityGO:00513451480.011
rna processingGO:00063961050.011
tissue homeostasisGO:00018941150.011
gland developmentGO:00487323300.011
nuclear importGO:0051170950.011
hormone metabolic processGO:0042445860.011
hematopoietic progenitor cell differentiationGO:00022441430.011
nuclear transportGO:00511691390.011
regulation of nucleotide metabolic processGO:00061401690.011
organelle fissionGO:00482851700.011
regulation of cellular component sizeGO:00325351210.011
cellular alcohol biosynthetic processGO:004410830.011
regulation of fatty acid biosynthetic processGO:0042304120.011
regulation of cell adhesionGO:00301551540.011
nucleoside phosphate biosynthetic processGO:1901293790.011
myosin filament organizationGO:003103330.011
regulation of neuron projection developmentGO:00109751690.011
regulation of phospholipid catabolic processGO:006069620.011
reactive oxygen species biosynthetic processGO:190340980.011
positive regulation of mapk cascadeGO:00434101700.011
epithelial cell proliferationGO:00506731740.011
pyridine containing compound metabolic processGO:0072524140.011
glycoprotein biosynthetic processGO:0009101890.011
chromatin organizationGO:00063252060.011
nucleoside monophosphate metabolic processGO:0009123850.011
positive regulation of nucleotide metabolic processGO:00459811140.011
regulation of removal of superoxide radicalsGO:200012140.011
regulation of triglyceride metabolic processGO:0090207170.011
limb developmentGO:00601731660.011
lymphocyte differentiationGO:00300982420.011
regulation of cardiac muscle contractionGO:0055117210.011
regulation of protein processingGO:0070613960.011
epithelial tube morphogenesisGO:00605623030.011
mitotic cytokinesisGO:000028140.011
response to reactive oxygen speciesGO:0000302560.011
regulation of mitochondrial fissionGO:009014030.011
negative regulation of protein serine threonine kinase activityGO:0071901490.011
mature dendritic cell differentiationGO:009702930.011
regulation of metal ion transportGO:00109591060.011
organic hydroxy compound catabolic processGO:1901616250.011
purine containing compound biosynthetic processGO:0072522700.011
angiogenesisGO:00015252010.011
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:00024601450.011
interleukin 8 productionGO:003263740.011
regulation of cell migrationGO:00303342190.011
rho protein signal transductionGO:0007266320.011
positive regulation of cell activationGO:00508671580.011
polyamine catabolic processGO:000659820.010
positive regulation of striated muscle contractionGO:004598930.010
regulation of blood circulationGO:1903522930.010
organelle localizationGO:00516401790.010
oxidoreduction coenzyme metabolic processGO:0006733160.010
cellular alcohol metabolic processGO:004410730.010
positive regulation of defense responseGO:00313491240.010
positive regulation of reactive oxygen species metabolic processGO:2000379110.010
regulation of t cell activationGO:00508631700.010
nuclear divisionGO:00002801580.010
calcium ion homeostasisGO:00550741270.010
primary alcohol metabolic processGO:0034308110.010
xenobiotic catabolic processGO:004217810.010
glucose homeostasisGO:00425931280.010
fatty acid biosynthetic processGO:0006633410.010
vitamin d biosynthetic processGO:004236830.010
cardiac muscle cell contractionGO:008600370.010
myeloid cell homeostasisGO:00022621140.010
interleukin 12 secretionGO:007261030.010
developmental maturationGO:00217001930.010
regulation of fatty acid beta oxidationGO:003199810.010
calcitriol biosynthetic process from calciolGO:003637830.010
regulation of muscle contractionGO:0006937490.010
single organism cell adhesionGO:00986021560.010
regulation of intracellular transportGO:00323861590.010
defense response to bacteriumGO:00427421190.010

Pdk4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
nervous system diseaseDOID:86300.048
disease of anatomical entityDOID:700.048
disease of metabolismDOID:001466700.031
musculoskeletal system diseaseDOID:1700.022
muscular diseaseDOID:008000000.022
neuropathyDOID:87000.021
neuromuscular diseaseDOID:44000.021
charcot marie tooth diseaseDOID:1059500.017
immune system diseaseDOID:291400.016
hematopoietic system diseaseDOID:7400.015
sensory system diseaseDOID:005015500.015
eye and adnexa diseaseDOID:149200.014
cardiovascular system diseaseDOID:128700.013
eye diseaseDOID:561400.013
myopathyDOID:42300.013
muscle tissue diseaseDOID:6600.013
inherited metabolic disorderDOID:65500.012
central nervous system diseaseDOID:33100.011
acquired metabolic diseaseDOID:006015800.011
neurodegenerative diseaseDOID:128900.010