IMP: Integrative Multi-species Prediction

Mus musculus

107 known processes

Ring1

ring finger protein 1

(Aliases: MGC91250,Ring1A)

Ensembl: ENSMUSG00000024325
Entrez: 19763
UniProtKB: O35730

Process Predictions
Disease Predictions

Ring1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
positive regulation of immature t cell proliferation	GO:0033091	4	0.966
cell cycle comprising mitosis without cytokinesis	GO:0033301	1	0.922
mitotic cell cycle embryonic	GO:0045448	5	0.699
histone h2a monoubiquitination	GO:0035518	1	0.560	Human Mouse Fly
response to ionizing radiation	GO:0010212	42	0.525
regionalization	GO:0003002	337	0.505
protein modification by small protein conjugation	GO:0032446	187	0.497
histone h2a ubiquitination	GO:0033522	3	0.482	Human Mouse Worm Fly
chromatin modification	GO:0016568	187	0.463
covalent chromatin modification	GO:0016569	163	0.414
trunk segmentation	GO:0035290	4	0.356
protein modification by small protein conjugation or removal	GO:0070647	207	0.353
protein ubiquitination	GO:0016567	171	0.317
proteasomal protein catabolic process	GO:0010498	98	0.305
histone modification	GO:0016570	159	0.291
dna metabolic process	GO:0006259	303	0.279
dna methylation	GO:0006306	43	0.261
camera type eye development	GO:0043010	266	0.261
regulation of apoptotic signaling pathway	GO:2001233	197	0.233
skeletal system development	GO:0001501	356	0.186
skeletal system morphogenesis	GO:0048705	203	0.183
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.177
neural tube patterning	GO:0021532	43	0.175
rostrocaudal neural tube patterning	GO:0021903	12	0.172
mitotic cell cycle	GO:0000278	195	0.166	Mouse
cellular protein catabolic process	GO:0044257	155	0.145
scf dependent proteasomal ubiquitin dependent protein catabolic process	GO:0031146	10	0.145
ubiquitin dependent protein catabolic process	GO:0006511	129	0.121
proteolysis involved in cellular protein catabolic process	GO:0051603	147	0.118
kidney development	GO:0001822	213	0.113
dna modification	GO:0006304	50	0.104
cellular macromolecule catabolic process	GO:0044265	206	0.100
gland development	GO:0048732	330	0.098
peptidyl amino acid modification	GO:0018193	336	0.094
peptidyl lysine modification	GO:0018205	77	0.093
response to reactive oxygen species	GO:0000302	56	0.091
segmentation	GO:0035282	93	0.089
b cell proliferation	GO:0042100	53	0.086
modification dependent protein catabolic process	GO:0019941	133	0.084
histone lysine demethylation	GO:0070076	13	0.078
cell maturation	GO:0048469	127	0.077
neural tube development	GO:0021915	160	0.072
response to radiation	GO:0009314	165	0.070
ribose phosphate metabolic process	GO:0019693	291	0.066
protein sumoylation	GO:0016925	14	0.061
positive regulation of t cell differentiation in thymus	GO:0033089	13	0.061
internal protein amino acid acetylation	GO:0006475	42	0.060
regulation of immature t cell proliferation in thymus	GO:0033084	6	0.060
histone monoubiquitination	GO:0010390	3	0.058	Human Mouse Fly
protein localization to nucleus	GO:0034504	121	0.057
leukocyte proliferation	GO:0070661	172	0.055
sebaceous gland development	GO:0048733	7	0.054
response to hydrogen peroxide	GO:0042542	32	0.054
methylation	GO:0032259	134	0.054
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	88	0.054
segment specification	GO:0007379	15	0.053
lymphocyte differentiation	GO:0030098	242	0.051
positive regulation of lymphocyte differentiation	GO:0045621	61	0.049
positive regulation of b cell activation	GO:0050871	49	0.048
nucleobase containing small molecule metabolic process	GO:0055086	352	0.046
urogenital system development	GO:0001655	261	0.045
apoptotic signaling pathway	GO:0097190	306	0.045
anatomical structure homeostasis	GO:0060249	145	0.044
regulation of cellular ketone metabolic process	GO:0010565	66	0.044
tube formation	GO:0035148	140	0.043
nucleotide metabolic process	GO:0009117	332	0.041
cellular response to oxidative stress	GO:0034599	76	0.040
negative regulation of cellular protein metabolic process	GO:0032269	247	0.040
embryonic epithelial tube formation	GO:0001838	130	0.039
response to acid chemical	GO:0001101	111	0.038
embryonic skeletal system morphogenesis	GO:0048704	91	0.038
gene silencing	GO:0016458	38	0.037	Fly
glycosyl compound metabolic process	GO:1901657	246	0.037
embryonic skeletal system development	GO:0048706	120	0.036
chromatin organization	GO:0006325	206	0.036
cellular ketone metabolic process	GO:0042180	84	0.036
regulation of epithelial cell proliferation	GO:0050678	141	0.035
regulation of cell activation	GO:0050865	289	0.035
renal system development	GO:0072001	225	0.035
regulation of b cell activation	GO:0050864	81	0.034
single organism nuclear import	GO:1902593	95	0.034
protein import into peroxisome matrix	GO:0016558	3	0.034
connective tissue development	GO:0061448	179	0.033
embryonic organ morphogenesis	GO:0048562	276	0.033
cellular amino acid metabolic process	GO:0006520	103	0.032
telencephalon development	GO:0021537	186	0.031
protein localization to organelle	GO:0033365	185	0.031
nitrogen compound transport	GO:0071705	271	0.030
regulation of neuron differentiation	GO:0045664	281	0.030
modification dependent macromolecule catabolic process	GO:0043632	133	0.030
regulation of t cell proliferation	GO:0042129	92	0.029
b cell activation	GO:0042113	161	0.029
regulation of leukocyte differentiation	GO:1902105	159	0.028
protein methylation	GO:0006479	81	0.028
cell division	GO:0051301	120	0.028
nuclear import	GO:0051170	95	0.027
purine ribonucleotide metabolic process	GO:0009150	290	0.027
developmental maturation	GO:0021700	193	0.026
purine containing compound catabolic process	GO:0072523	213	0.026
negative regulation of gene expression epigenetic	GO:0045814	15	0.026	Worm Fly
carbohydrate derivative biosynthetic process	GO:1901137	183	0.026
cellular response to acid chemical	GO:0071229	68	0.026
response to inorganic substance	GO:0010035	96	0.025
positive regulation of cellular amine metabolic process	GO:0033240	5	0.025
t cell activation	GO:0042110	289	0.025
histone acetylation	GO:0016573	41	0.025
spermatogenesis	GO:0007283	284	0.024
protein import	GO:0017038	101	0.024
leukocyte differentiation	GO:0002521	342	0.024
positive regulation of immature t cell proliferation in thymus	GO:0033092	3	0.024
immature t cell proliferation in thymus	GO:0033080	7	0.023
cartilage development	GO:0051216	140	0.023
negative regulation of cell proliferation	GO:0008285	296	0.023
nucleoside phosphate catabolic process	GO:1901292	222	0.023
nucleoside triphosphate metabolic process	GO:0009141	230	0.023
cellular nitrogen compound catabolic process	GO:0044270	280	0.023
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.023
purine nucleotide catabolic process	GO:0006195	211	0.023
purine nucleoside catabolic process	GO:0006152	205	0.022
regulation of t cell activation	GO:0050863	170	0.022
macromolecule catabolic process	GO:0009057	281	0.022
response to molecule of bacterial origin	GO:0002237	143	0.022
translation	GO:0006412	93	0.021
posttranscriptional regulation of gene expression	GO:0010608	155	0.021
response to organic cyclic compound	GO:0014070	198	0.021
dna alkylation	GO:0006305	43	0.021
purine nucleoside metabolic process	GO:0042278	241	0.021
positive regulation of t cell proliferation	GO:0042102	52	0.021
nucleoside metabolic process	GO:0009116	246	0.020
stem cell division	GO:0017145	30	0.020
neuron death	GO:0070997	154	0.020
hindbrain development	GO:0030902	128	0.020
histone demethylation	GO:0016577	13	0.019
amide transport	GO:0042886	138	0.019
cellular response to molecule of bacterial origin	GO:0071219	83	0.019
positive regulation of lymphocyte proliferation	GO:0050671	70	0.019
regulation of organelle organization	GO:0033043	289	0.019
phospholipid transfer to membrane	GO:0006649	2	0.019
histone ubiquitination	GO:0016574	10	0.018
response to organonitrogen compound	GO:0010243	246	0.018
carbohydrate derivative catabolic process	GO:1901136	231	0.018
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.018
organic cyclic compound catabolic process	GO:1901361	295	0.018
chondrocyte differentiation	GO:0002062	72	0.018
retina development in camera type eye	GO:0060041	119	0.017
regulation of cell cycle	GO:0051726	281	0.017
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.017
positive regulation of cell activation	GO:0050867	158	0.017
negative regulation of protein metabolic process	GO:0051248	282	0.017
regulation of neuron death	GO:1901214	134	0.017
regulation of system process	GO:0044057	200	0.017
protein catabolic process	GO:0030163	221	0.017
placenta development	GO:0001890	140	0.017
lung development	GO:0030324	164	0.016
heterocycle catabolic process	GO:0046700	280	0.016
peptidyl lysine acetylation	GO:0018394	45	0.016
cellular response to biotic stimulus	GO:0071216	92	0.016
epithelial cell proliferation	GO:0050673	174	0.016
purine ribonucleoside metabolic process	GO:0046128	241	0.016
amine metabolic process	GO:0009308	45	0.016
regulation of homeostatic process	GO:0032844	182	0.016
multicellular organism growth	GO:0035264	161	0.016
compound eye development	GO:0048749	1	0.016
monocarboxylic acid metabolic process	GO:0032787	191	0.015
cell type specific apoptotic process	GO:0097285	268	0.015
respiratory system development	GO:0060541	190	0.015
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.015
response to oxidative stress	GO:0006979	123	0.015
protein targeting	GO:0006605	143	0.015
wound healing	GO:0042060	157	0.015
glycosyl compound catabolic process	GO:1901658	206	0.015
response to lipopolysaccharide	GO:0032496	128	0.015
cellular response to retinoic acid	GO:0071300	25	0.015
regulation of lymphocyte differentiation	GO:0045619	107	0.014
nucleoside phosphate metabolic process	GO:0006753	338	0.014
peptide transport	GO:0015833	133	0.014
regulation of cellular amino acid metabolic process	GO:0006521	5	0.014
chromatin silencing	GO:0006342	15	0.014	Fly
midbrain hindbrain boundary development	GO:0030917	9	0.014
rna processing	GO:0006396	105	0.014
fat cell differentiation	GO:0045444	160	0.014
respiratory tube development	GO:0030323	167	0.014
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.014
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.014
embryonic placenta development	GO:0001892	98	0.014
intracellular receptor signaling pathway	GO:0030522	74	0.014
sensory organ morphogenesis	GO:0090596	242	0.014
i kappab kinase nf kappab signaling	GO:0007249	85	0.014
multicellular organismal response to stress	GO:0033555	62	0.013
multicellular organismal homeostasis	GO:0048871	164	0.013
organonitrogen compound catabolic process	GO:1901565	264	0.013
muscle system process	GO:0003012	141	0.013
regulation of hormone levels	GO:0010817	211	0.013
nuclear division	GO:0000280	158	0.013
regulation of hydrolase activity	GO:0051336	246	0.013
cellular response to lipopolysaccharide	GO:0071222	77	0.013
purine containing compound metabolic process	GO:0072521	311	0.013
intrinsic apoptotic signaling pathway	GO:0097193	132	0.013
cell substrate adhesion	GO:0031589	130	0.012
intracellular protein transport	GO:0006886	204	0.012
metencephalon development	GO:0022037	89	0.012
response to drug	GO:0042493	75	0.012
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.012
positive regulation of lymphocyte activation	GO:0051251	140	0.012
single fertilization	GO:0007338	82	0.012
nucleotide catabolic process	GO:0009166	217	0.012
oxidation reduction process	GO:0055114	342	0.012
sensory perception	GO:0007600	245	0.012
regulation of cell cycle process	GO:0010564	160	0.012
morphogenesis of embryonic epithelium	GO:0016331	159	0.012
regulation of embryonic development	GO:0045995	71	0.012
homeostasis of number of cells	GO:0048872	210	0.012
positive regulation of leukocyte differentiation	GO:1902107	86	0.012
muscle tissue development	GO:0060537	308	0.012
heterochromatin organization	GO:0070828	4	0.012
peptidyl serine modification	GO:0018209	83	0.012
epidermis development	GO:0008544	187	0.011
nucleoside catabolic process	GO:0009164	206	0.011
response to gamma radiation	GO:0010332	22	0.011
organelle fission	GO:0048285	170	0.011
gastrulation	GO:0007369	116	0.011	Mouse
negative regulation of cell migration	GO:0030336	59	0.011
digestive system development	GO:0055123	200	0.011	Mouse
multi multicellular organism process	GO:0044706	109	0.011
steroid metabolic process	GO:0008202	119	0.011
positive regulation of t cell differentiation	GO:0045582	52	0.011
ribonucleotide metabolic process	GO:0009259	291	0.011
lymphocyte mediated immunity	GO:0002449	139	0.011
positive regulation of t cell activation	GO:0050870	101	0.011
humoral immune response	GO:0006959	57	0.011
negative regulation of neuron apoptotic process	GO:0043524	92	0.011
purine ribonucleotide catabolic process	GO:0009154	208	0.011
microtubule based process	GO:0007017	236	0.011
fertilization	GO:0009566	127	0.011
positive regulation of stem cell proliferation	GO:2000648	59	0.011
purine ribonucleoside monophosphate metabolic process	GO:0009167	80	0.011
demethylation	GO:0070988	23	0.011
organophosphate biosynthetic process	GO:0090407	122	0.010
phosphatidic acid biosynthetic process	GO:0006654	2	0.010
macromolecule methylation	GO:0043414	120	0.010
positive regulation of b cell proliferation	GO:0030890	24	0.010
forebrain development	GO:0030900	302	0.010
transmembrane transport	GO:0055085	412	0.010
regulation of muscle tissue development	GO:1901861	97	0.010
establishment of protein localization to organelle	GO:0072594	118	0.010
cytokine production	GO:0001816	319	0.010
skeletal muscle organ development	GO:0060538	163	0.010
ribonucleoside monophosphate catabolic process	GO:0009158	57	0.010
metanephric glomerular epithelium development	GO:0072244	3	0.010
negative regulation of intrinsic apoptotic signaling pathway	GO:2001243	34	0.010
protein homotrimerization	GO:0070207	4	0.010
regulation of anterior head development	GO:2000742	2	0.010

Ring1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.018
nervous system disease	DOID:863	0.018
central nervous system disease	DOID:331	0.012
neurodegenerative disease	DOID:1289	0.012

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