IMP: Integrative Multi-species Prediction

Mus musculus

120 known processes

Ift74

intraflagellar transport 74 homolog (Chlamydomonas)

(Aliases: Ccdc2,1700029H06Rik,Cmg1)

Entrez: 67694
Ensembl: ENSMUSG00000028576
UniProtKB: Q8BKE9
UniProtKB: B1AWG1

Process Predictions
Disease Predictions

Ift74 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
cilium assembly	GO:0042384	81	0.997
cilium morphogenesis	GO:0060271	102	0.927
intraciliary transport	GO:0042073	9	0.917
cellular component assembly involved in morphogenesis	GO:0010927	139	0.887
microtubule based movement	GO:0007018	84	0.747
organelle assembly	GO:0070925	177	0.655
cytoskeleton dependent intracellular transport	GO:0030705	50	0.603
axoneme assembly	GO:0035082	15	0.516
epithelial cilium movement	GO:0003351	12	0.494
microtubule based transport	GO:0010970	50	0.457
smoothened signaling pathway	GO:0007224	105	0.384
intraciliary retrograde transport	GO:0035721	3	0.265
cilium movement	GO:0003341	28	0.140
retina development in camera type eye	GO:0060041	119	0.138
nonmotile primary cilium assembly	GO:0035058	8	0.134
determination of left right symmetry	GO:0007368	80	0.111
eye photoreceptor cell differentiation	GO:0001754	41	0.105
regulation of cilium assembly	GO:1902017	7	0.105
photoreceptor cell differentiation	GO:0046530	52	0.105
photoreceptor cell development	GO:0042461	40	0.088
sensory organ morphogenesis	GO:0090596	242	0.088
camera type eye development	GO:0043010	266	0.083
epithelial tube formation	GO:0072175	130	0.081
dna repair	GO:0006281	107	0.079
regionalization	GO:0003002	337	0.064
microtubule based process	GO:0007017	236	0.063
primary neural tube formation	GO:0014020	95	0.054
neural tube development	GO:0021915	160	0.053
left right pattern formation	GO:0060972	23	0.052
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.049
renal system development	GO:0072001	225	0.049
tube closure	GO:0060606	91	0.046
establishment of organelle localization	GO:0051656	122	0.045
microtubule cytoskeleton organization	GO:0000226	157	0.044
regulation of smoothened signaling pathway	GO:0008589	58	0.044
appendage development	GO:0048736	166	0.043
digestive tract morphogenesis	GO:0048546	147	0.042
negative regulation of cell proliferation	GO:0008285	296	0.041
tube formation	GO:0035148	140	0.041
sensory perception	GO:0007600	245	0.041
regulation of cell projection organization	GO:0031344	206	0.038
regulation of cellular amino acid metabolic process	GO:0006521	5	0.036
cell type specific apoptotic process	GO:0097285	268	0.035
regulation of cellular response to stress	GO:0080135	159	0.034
regulation of organelle organization	GO:0033043	289	0.032
epithelial tube morphogenesis	GO:0060562	303	0.032
muscle cell differentiation	GO:0042692	261	0.032
organelle localization	GO:0051640	179	0.031
digestive system development	GO:0055123	200	0.031
regulation of epithelial cell proliferation	GO:0050678	141	0.030
neural tube formation	GO:0001841	108	0.030
carbohydrate derivative catabolic process	GO:1901136	231	0.030
eye photoreceptor cell development	GO:0042462	31	0.030
cellular response to dna damage stimulus	GO:0006974	207	0.030
hematopoietic progenitor cell differentiation	GO:0002244	143	0.029
cellular ketone metabolic process	GO:0042180	84	0.029
vesicle localization	GO:0051648	86	0.029
purine ribonucleotide metabolic process	GO:0009150	290	0.028
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.028
regulation of cellular ketone metabolic process	GO:0010565	66	0.028
muscle tissue development	GO:0060537	308	0.027
glycosyl compound catabolic process	GO:1901658	206	0.027
urogenital system development	GO:0001655	261	0.027
dna metabolic process	GO:0006259	303	0.027
amine metabolic process	GO:0009308	45	0.026
forebrain development	GO:0030900	302	0.026
regulation of cellular amine metabolic process	GO:0033238	20	0.026
cellular amino acid metabolic process	GO:0006520	103	0.025
telencephalon development	GO:0021537	186	0.025
immune effector process	GO:0002252	321	0.025
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.024
transmission of nerve impulse	GO:0019226	76	0.024
cellular amine metabolic process	GO:0044106	44	0.024
ribonucleoside catabolic process	GO:0042454	206	0.024
purine nucleotide metabolic process	GO:0006163	302	0.024
striated muscle tissue development	GO:0014706	293	0.024
digestive tract development	GO:0048565	190	0.023
organophosphate catabolic process	GO:0046434	232	0.023
male gamete generation	GO:0048232	285	0.023
regulation of nucleotide metabolic process	GO:0006140	169	0.023
cellular nitrogen compound catabolic process	GO:0044270	280	0.023
purine containing compound metabolic process	GO:0072521	311	0.023
nucleoside metabolic process	GO:0009116	246	0.022
skin development	GO:0043588	220	0.022
nucleotide catabolic process	GO:0009166	217	0.022
nucleotide metabolic process	GO:0009117	332	0.022
purine ribonucleoside catabolic process	GO:0046130	205	0.022
establishment of pigment granule localization	GO:0051905	12	0.022
regulation of cell cycle	GO:0051726	281	0.022
limb development	GO:0060173	166	0.021
sensory perception of mechanical stimulus	GO:0050954	107	0.021
establishment of melanosome localization	GO:0032401	11	0.021
sensory perception of light stimulus	GO:0050953	54	0.021
purine nucleotide catabolic process	GO:0006195	211	0.021
positive regulation of protein modification process	GO:0031401	299	0.021
spermatogenesis	GO:0007283	284	0.021
morphogenesis of embryonic epithelium	GO:0016331	159	0.021
small gtpase mediated signal transduction	GO:0007264	97	0.020
regulation of cellular component biogenesis	GO:0044087	181	0.020
positive regulation of nervous system development	GO:0051962	221	0.020
establishment of anatomical structure orientation	GO:0048560	1	0.020
notch signaling pathway	GO:0007219	71	0.020
gastrulation	GO:0007369	116	0.020
nucleobase containing small molecule metabolic process	GO:0055086	352	0.020
heart morphogenesis	GO:0003007	178	0.020
heterocycle catabolic process	GO:0046700	280	0.019
glycosyl compound metabolic process	GO:1901657	246	0.019
lateral inhibition	GO:0046331	1	0.019
positive regulation of cellular amine metabolic process	GO:0033240	5	0.019
nucleoside phosphate metabolic process	GO:0006753	338	0.019
regulation of cell cycle process	GO:0010564	160	0.019
protein catabolic process	GO:0030163	221	0.019
protein localization to organelle	GO:0033365	185	0.018
response to radiation	GO:0009314	165	0.018
regulation of purine nucleotide metabolic process	GO:1900542	169	0.018
visual perception	GO:0007601	52	0.018
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.018
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.018
ribonucleoside metabolic process	GO:0009119	245	0.018
rna processing	GO:0006396	105	0.018
spermatid development	GO:0007286	108	0.018
adult behavior	GO:0030534	135	0.018
photoreceptor cell maintenance	GO:0045494	19	0.018
organonitrogen compound catabolic process	GO:1901565	264	0.018
regulation of cellular response to growth factor stimulus	GO:0090287	82	0.017
neural tube closure	GO:0001843	90	0.017
retina morphogenesis in camera type eye	GO:0060042	45	0.017
regulation of sequence specific dna binding transcription factor activity	GO:0051090	106	0.017
lymphocyte mediated immunity	GO:0002449	139	0.017
nucleoside phosphate catabolic process	GO:1901292	222	0.017
purine nucleoside metabolic process	GO:0042278	241	0.017
epithelial cell proliferation	GO:0050673	174	0.017
kidney development	GO:0001822	213	0.016
negative regulation of molecular function	GO:0044092	258	0.016
purine ribonucleotide catabolic process	GO:0009154	208	0.016
determination of heart left right asymmetry	GO:0061371	48	0.016
aromatic compound catabolic process	GO:0019439	286	0.016
skeletal muscle organ development	GO:0060538	163	0.016
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.016
production of molecular mediator of immune response	GO:0002440	103	0.016
melanosome localization	GO:0032400	12	0.016
ribonucleotide catabolic process	GO:0009261	208	0.016
leukocyte mediated immunity	GO:0002443	174	0.015
ribonucleotide metabolic process	GO:0009259	291	0.015
membrane organization	GO:0061024	245	0.015
skeletal system development	GO:0001501	356	0.015
ribonucleoside triphosphate catabolic process	GO:0009203	199	0.015
nitrogen compound transport	GO:0071705	271	0.015
fat cell differentiation	GO:0045444	160	0.015
purine ribonucleoside metabolic process	GO:0046128	241	0.015
germ cell development	GO:0007281	185	0.015
dna recombination	GO:0006310	92	0.015
purine nucleoside catabolic process	GO:0006152	205	0.015
regulation of protein localization	GO:0032880	231	0.015
response to light stimulus	GO:0009416	135	0.015
purine containing compound catabolic process	GO:0072523	213	0.015
regulation of neuron death	GO:1901214	134	0.015
adaptive immune response	GO:0002250	155	0.015
ribose phosphate metabolic process	GO:0019693	291	0.015
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	88	0.015
protein modification by small protein conjugation or removal	GO:0070647	207	0.015
establishment of vesicle localization	GO:0051650	81	0.014
stem cell maintenance	GO:0019827	130	0.014
b cell activation	GO:0042113	161	0.014
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.014
neuron apoptotic process	GO:0051402	142	0.013
response to growth factor	GO:0070848	198	0.013
nucleoside triphosphate catabolic process	GO:0009143	205	0.013
stem cell development	GO:0048864	219	0.013
nucleoside triphosphate metabolic process	GO:0009141	230	0.013
apoptotic signaling pathway	GO:0097190	306	0.013
positive regulation of nucleotide metabolic process	GO:0045981	114	0.013
lymphocyte differentiation	GO:0030098	242	0.013
protein maturation	GO:0051604	176	0.013
neuronal action potential	GO:0019228	54	0.013
modification dependent protein catabolic process	GO:0019941	133	0.013
proteasomal protein catabolic process	GO:0010498	98	0.013
regulation of binding	GO:0051098	111	0.013
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002460	145	0.013
limb morphogenesis	GO:0035108	149	0.013
organic cyclic compound catabolic process	GO:1901361	295	0.013
stem cell differentiation	GO:0048863	268	0.013
muscle cell development	GO:0055001	133	0.013
embryonic heart tube development	GO:0035050	65	0.013
purine ribonucleoside monophosphate catabolic process	GO:0009169	57	0.013
appendage morphogenesis	GO:0035107	149	0.013
cytoplasmic transport	GO:0016482	234	0.013
regulation of cell cycle g1 s phase transition	GO:1902806	35	0.012
atp catabolic process	GO:0006200	55	0.012
regulation of homeostatic process	GO:0032844	182	0.012
rna splicing	GO:0008380	54	0.012
cellular response to growth factor stimulus	GO:0071363	197	0.012
establishment or maintenance of cell polarity	GO:0007163	86	0.012
cardiac muscle tissue development	GO:0048738	130	0.012
sensory perception of sound	GO:0007605	97	0.012
striated muscle cell development	GO:0055002	125	0.012
regulation of cellular catabolic process	GO:0031329	242	0.012
negative regulation of intracellular signal transduction	GO:1902532	167	0.012
regulation of hormone levels	GO:0010817	211	0.012
maintenance of location	GO:0051235	89	0.012
regulation of protein maturation	GO:1903317	96	0.012
synapse organization	GO:0050808	125	0.012
multicellular organismal homeostasis	GO:0048871	164	0.012
ribonucleoside monophosphate catabolic process	GO:0009158	57	0.011
cell division	GO:0051301	120	0.011
regulation of striated muscle cell differentiation	GO:0051153	81	0.011
peptidyl lysine modification	GO:0018205	77	0.011
wnt signaling pathway	GO:0016055	188	0.011
proteolysis involved in cellular protein catabolic process	GO:0051603	147	0.011
positive regulation of immature t cell proliferation	GO:0033091	4	0.011
regulation of nucleoside metabolic process	GO:0009118	130	0.011
neural retina development	GO:0003407	41	0.011
embryonic epithelial tube formation	GO:0001838	130	0.011
action potential	GO:0001508	78	0.011
regulation of membrane potential	GO:0042391	192	0.011
regulation of cell cycle phase transition	GO:1901987	77	0.011
sequestering of calcium ion	GO:0051208	18	0.011
positive regulation of cell projection organization	GO:0031346	95	0.011
peptidyl amino acid modification	GO:0018193	336	0.011
ear development	GO:0043583	200	0.011
transmembrane transport	GO:0055085	412	0.011
meiotic nuclear division	GO:0007126	115	0.011
atp metabolic process	GO:0046034	75	0.011
cell growth	GO:0016049	130	0.011
negative regulation of cellular response to growth factor stimulus	GO:0090288	46	0.011
trna processing	GO:0008033	11	0.011
regulation of intracellular transport	GO:0032386	159	0.011
t cell activation	GO:0042110	289	0.011
embryonic digit morphogenesis	GO:0042733	56	0.010
regulation of protein processing	GO:0070613	96	0.010
cation transmembrane transport	GO:0098655	266	0.010
multicellular organismal signaling	GO:0035637	91	0.010
cellular homeostasis	GO:0019725	240	0.010
homeostasis of number of cells	GO:0048872	210	0.010
cellular protein catabolic process	GO:0044257	155	0.010
regulation of neuron apoptotic process	GO:0043523	122	0.010
developmental growth involved in morphogenesis	GO:0060560	138	0.010
lymphocyte activation involved in immune response	GO:0002285	93	0.010
regulation of cytoskeleton organization	GO:0051493	122	0.010
leukocyte activation involved in immune response	GO:0002366	126	0.010
microtubule anchoring at microtubule organizing center	GO:0072393	5	0.010
regulation of cell growth	GO:0001558	91	0.010

Ift74 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
eye disease	DOID:5614	0.070
eye and adnexa disease	DOID:1492	0.070
disease of anatomical entity	DOID:7	0.070
nervous system disease	DOID:863	0.070
sensory system disease	DOID:0050155	0.070
retinal disease	DOID:5679	0.070
disease of cellular proliferation	DOID:14566	0.028
cancer	DOID:162	0.028
organ system cancer	DOID:0050686	0.024
retinal degeneration	DOID:8466	0.023

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