IMP: Integrative Multi-species Prediction

Mus musculus

67 known processes

Pcgf6

polycomb group ring finger 6

(Aliases: 4933407A11Rik,AI604840,MGC106622,Rnf134,MBLR)

Entrez: 71041
Ensembl: ENSMUSG00000025050
UniProtKB: Q99NA9

Process Predictions
Disease Predictions

Pcgf6 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
positive regulation of immature t cell proliferation	GO:0033091	4	0.897	Mouse
covalent chromatin modification	GO:0016569	163	0.728	Mouse
histone h2a ubiquitination	GO:0033522	3	0.575
protein modification by small protein conjugation or removal	GO:0070647	207	0.469	Mouse
histone h2a monoubiquitination	GO:0035518	1	0.464
methylation	GO:0032259	134	0.405	Mouse
chromatin modification	GO:0016568	187	0.393	Mouse
dna methylation	GO:0006306	43	0.393	Mouse
dna metabolic process	GO:0006259	303	0.376	Mouse
histone modification	GO:0016570	159	0.314	Mouse
gene silencing	GO:0016458	38	0.304
regionalization	GO:0003002	337	0.297	Mouse
histone methylation	GO:0016571	71	0.279
protein modification by small protein conjugation	GO:0032446	187	0.239	Mouse
trunk segmentation	GO:0035290	4	0.215
histone monoubiquitination	GO:0010390	3	0.212
apoptotic signaling pathway	GO:0097190	306	0.155	Mouse
protein ubiquitination	GO:0016567	171	0.153	Mouse
protein methylation	GO:0006479	81	0.113
mitotic cell cycle	GO:0000278	195	0.110
neural tube development	GO:0021915	160	0.104	Mouse
cell cycle comprising mitosis without cytokinesis	GO:0033301	1	0.092
germ cell development	GO:0007281	185	0.092
internal protein amino acid acetylation	GO:0006475	42	0.088	Mouse
protein alkylation	GO:0008213	81	0.087
chromatin organization	GO:0006325	206	0.086	Mouse
skeletal system development	GO:0001501	356	0.085	Mouse
dna modification	GO:0006304	50	0.080	Mouse
response to radiation	GO:0009314	165	0.078
developmental maturation	GO:0021700	193	0.077
peptidyl amino acid modification	GO:0018193	336	0.075	Mouse
regulation of cell cycle	GO:0051726	281	0.071
regulation of apoptotic signaling pathway	GO:2001233	197	0.070	Mouse
peptidyl lysine modification	GO:0018205	77	0.070	Mouse
regulation of histone h3 k36 methylation	GO:0000414	1	0.069
positive regulation of cell activation	GO:0050867	158	0.066	Mouse
cellular response to dna damage stimulus	GO:0006974	207	0.064
mrna splicing via spliceosome	GO:0000398	43	0.061
camera type eye development	GO:0043010	266	0.060
regulation of lymphocyte activation	GO:0051249	240	0.059	Mouse
regulation of cellular component biogenesis	GO:0044087	181	0.059
macromolecule methylation	GO:0043414	120	0.059	Mouse
response to ionizing radiation	GO:0010212	42	0.059
dna alkylation	GO:0006305	43	0.058	Mouse
regulation of protein complex assembly	GO:0043254	83	0.057
regulation of intrinsic apoptotic signaling pathway	GO:2001242	61	0.053
histone ubiquitination	GO:0016574	10	0.052	Mouse
organelle assembly	GO:0070925	177	0.051
ribose phosphate metabolic process	GO:0019693	291	0.050
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.050	Mouse
cellular ketone metabolic process	GO:0042180	84	0.048
signal transduction by p53 class mediator	GO:0072331	51	0.047
lymphocyte differentiation	GO:0030098	242	0.045	Mouse
immature t cell proliferation	GO:0033079	8	0.045	Mouse
ubiquitin dependent protein catabolic process	GO:0006511	129	0.045
regulation of cell activation	GO:0050865	289	0.044	Mouse
cell maturation	GO:0048469	127	0.043
cellular protein complex assembly	GO:0043623	116	0.042
positive regulation of b cell activation	GO:0050871	49	0.041	Mouse
histone h3 k9 methylation	GO:0051567	17	0.040
t cell differentiation	GO:0030217	174	0.040	Mouse
rna processing	GO:0006396	105	0.039
histone acetylation	GO:0016573	41	0.038	Mouse
regulation of cellular amino acid metabolic process	GO:0006521	5	0.038
regulation of organelle organization	GO:0033043	289	0.038
proteasomal protein catabolic process	GO:0010498	98	0.038
intrinsic apoptotic signaling pathway	GO:0097193	132	0.037
negative regulation of gene expression epigenetic	GO:0045814	15	0.037
histone h3 k36 methylation	GO:0010452	6	0.037
proteolysis involved in cellular protein catabolic process	GO:0051603	147	0.037
cellular macromolecule catabolic process	GO:0044265	206	0.036
positive regulation of apoptotic process	GO:0043065	217	0.036
female gamete generation	GO:0007292	74	0.035
intracellular receptor signaling pathway	GO:0030522	74	0.035
regulation of cell cycle process	GO:0010564	160	0.034
nucleobase containing small molecule metabolic process	GO:0055086	352	0.034
protein acylation	GO:0043543	64	0.033	Mouse
ribonucleotide metabolic process	GO:0009259	291	0.033
organic cyclic compound catabolic process	GO:1901361	295	0.033
segmentation	GO:0035282	93	0.032
cellular protein catabolic process	GO:0044257	155	0.031
tube closure	GO:0060606	91	0.031
negative regulation of cellular component organization	GO:0051129	194	0.031
regulation of protein stability	GO:0031647	52	0.031
dendrite development	GO:0016358	115	0.030
positive regulation of organelle organization	GO:0010638	128	0.030
negative regulation of mitotic cell cycle	GO:0045930	58	0.029
regulation of leukocyte differentiation	GO:1902105	159	0.029	Mouse
spermatogenesis	GO:0007283	284	0.029
macromolecule catabolic process	GO:0009057	281	0.028
skeletal system morphogenesis	GO:0048705	203	0.028	Mouse
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.028
posttranscriptional regulation of gene expression	GO:0010608	155	0.027
mitotic cell cycle process	GO:1903047	159	0.027
heterocycle catabolic process	GO:0046700	280	0.027
meiotic cell cycle	GO:0051321	122	0.027
membrane organization	GO:0061024	245	0.027
regulation of mitotic cell cycle	GO:0007346	126	0.026
retina development in camera type eye	GO:0060041	119	0.026
regulation of transcription from rna polymerase iii promoter	GO:0006359	2	0.026
cellular amino acid metabolic process	GO:0006520	103	0.026
cell type specific apoptotic process	GO:0097285	268	0.026
modification dependent protein catabolic process	GO:0019941	133	0.026
organelle fission	GO:0048285	170	0.026
negative regulation of intrinsic apoptotic signaling pathway	GO:2001243	34	0.025
leukocyte differentiation	GO:0002521	342	0.025	Mouse
purine containing compound metabolic process	GO:0072521	311	0.025
nuclear division	GO:0000280	158	0.025
cellular nitrogen compound catabolic process	GO:0044270	280	0.025
purine ribonucleotide metabolic process	GO:0009150	290	0.024
nucleotide metabolic process	GO:0009117	332	0.024
negative regulation of dna replication	GO:0008156	4	0.024
negative regulation of organelle organization	GO:0010639	90	0.023
transcription from rna polymerase iii promoter	GO:0006383	3	0.023
rostrocaudal neural tube patterning	GO:0021903	12	0.023	Mouse
positive regulation of lymphocyte differentiation	GO:0045621	61	0.022	Mouse
response to acid chemical	GO:0001101	111	0.022
cajal body organization	GO:0030576	1	0.022
protein complex disassembly	GO:0043241	40	0.022
erythrocyte differentiation	GO:0030218	88	0.022
positive regulation of cellular component biogenesis	GO:0044089	94	0.022
cell division	GO:0051301	120	0.022	Mouse
homeostasis of number of cells	GO:0048872	210	0.022
modification dependent macromolecule catabolic process	GO:0043632	133	0.022
oocyte construction	GO:0007308	2	0.021
nucleotide catabolic process	GO:0009166	217	0.021
purine nucleoside catabolic process	GO:0006152	205	0.021
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.021
nucleoside phosphate metabolic process	GO:0006753	338	0.021
nucleoside triphosphate metabolic process	GO:0009141	230	0.021
positive regulation of t cell activation	GO:0050870	101	0.021	Mouse
small gtpase mediated signal transduction	GO:0007264	97	0.021
glycosyl compound catabolic process	GO:1901658	206	0.021
chromosome organization involved in meiosis	GO:0070192	39	0.020
protein targeting	GO:0006605	143	0.020
regulation of cellular amine metabolic process	GO:0033238	20	0.020
negative regulation of molecular function	GO:0044092	258	0.020
oocyte axis specification	GO:0007309	2	0.020
glycosyl compound metabolic process	GO:1901657	246	0.019
embryonic epithelial tube formation	GO:0001838	130	0.019
chromatin silencing	GO:0006342	15	0.019
regulation of cell division	GO:0051302	76	0.019
digestive tract development	GO:0048565	190	0.019
ribonucleoside catabolic process	GO:0042454	206	0.019
nucleoside catabolic process	GO:0009164	206	0.019
positive regulation of t cell differentiation in thymus	GO:0033089	13	0.019	Mouse
gland development	GO:0048732	330	0.019
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.019
positive regulation of t cell proliferation	GO:0042102	52	0.019	Mouse
cellular amine metabolic process	GO:0044106	44	0.019
regulation of mrna metabolic process	GO:1903311	43	0.018
negative regulation of cell cycle	GO:0045786	123	0.018
axon guidance	GO:0007411	141	0.018
gastrulation	GO:0007369	116	0.018
histone lysine methylation	GO:0034968	50	0.018
positive regulation of cellular amine metabolic process	GO:0033240	5	0.018
ribonucleoside triphosphate catabolic process	GO:0009203	199	0.018
regulation of t cell proliferation	GO:0042129	92	0.017	Mouse
mitotic cell cycle embryonic	GO:0045448	5	0.017
cellular component assembly involved in morphogenesis	GO:0010927	139	0.017
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	88	0.017
respiratory tube development	GO:0030323	167	0.016
intracellular mrna localization	GO:0008298	4	0.016
nucleoside triphosphate catabolic process	GO:0009143	205	0.016
positive regulation of cell death	GO:0010942	224	0.016
regulation of cellular ketone metabolic process	GO:0010565	66	0.016
actin cytoskeleton organization	GO:0030036	220	0.016
purine containing compound catabolic process	GO:0072523	213	0.016
microtubule based process	GO:0007017	236	0.016
negative regulation of immune system process	GO:0002683	209	0.016
regulation of t cell activation	GO:0050863	170	0.016	Mouse
purine ribonucleotide catabolic process	GO:0009154	208	0.016
cell fate commitment	GO:0045165	210	0.016
aromatic compound catabolic process	GO:0019439	286	0.016
production of molecular mediator of immune response	GO:0002440	103	0.016
regulation of b cell activation	GO:0050864	81	0.016	Mouse
amine metabolic process	GO:0009308	45	0.015
embryonic skeletal system morphogenesis	GO:0048704	91	0.015	Mouse
myeloid cell differentiation	GO:0030099	233	0.015
neural tube patterning	GO:0021532	43	0.015	Mouse
mrna metabolic process	GO:0016071	84	0.015
carbohydrate derivative catabolic process	GO:1901136	231	0.015
negative regulation of intracellular signal transduction	GO:1902532	167	0.015
organonitrogen compound catabolic process	GO:1901565	264	0.015
purine nucleotide metabolic process	GO:0006163	302	0.015
regulation of smoothened signaling pathway	GO:0008589	58	0.015
mitotic chromosome condensation	GO:0007076	1	0.015
cellular response to acid chemical	GO:0071229	68	0.015
cell cycle checkpoint	GO:0000075	47	0.015
embryonic organ morphogenesis	GO:0048562	276	0.015	Mouse
cellular homeostasis	GO:0019725	240	0.014
cellular response to sterol	GO:0036315	2	0.014
endodermal cell fate specification	GO:0001714	4	0.014
sensory perception	GO:0007600	245	0.014
negative regulation of cell cycle process	GO:0010948	69	0.014
mrna processing	GO:0006397	63	0.014
negative regulation of cell cycle phase transition	GO:1901988	48	0.014
positive regulation of programmed cell death	GO:0043068	218	0.014
cytoplasmic transport	GO:0016482	234	0.014
transdifferentiation	GO:0060290	1	0.014
engulfment of apoptotic cell	GO:0043652	3	0.014
rna polyadenylation	GO:0043631	6	0.014
response to organic cyclic compound	GO:0014070	198	0.014
positive regulation of growth	GO:0045927	104	0.014
regulation of protein modification by small protein conjugation or removal	GO:1903320	57	0.014
protein monoubiquitination	GO:0006513	11	0.014
regulation of cell migration	GO:0030334	219	0.014
positive regulation of protein complex assembly	GO:0031334	45	0.014
dna templated transcription termination	GO:0006353	4	0.014
response to hydrogen peroxide	GO:0042542	32	0.014	Mouse
immune effector process	GO:0002252	321	0.014
t cell activation	GO:0042110	289	0.013	Mouse
regulation of protein processing	GO:0070613	96	0.013
histone deubiquitination	GO:0016578	2	0.013
wound healing	GO:0042060	157	0.013
cellular response to lipid	GO:0071396	145	0.013
b cell proliferation	GO:0042100	53	0.013	Mouse
response to reactive oxygen species	GO:0000302	56	0.013	Mouse
intracellular protein transport	GO:0006886	204	0.013
oxidation reduction process	GO:0055114	342	0.013
purine ribonucleoside metabolic process	GO:0046128	241	0.013
cilium morphogenesis	GO:0060271	102	0.013
heterochromatin organization	GO:0070828	4	0.013
nucleus organization	GO:0006997	45	0.013
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.012
b cell activation	GO:0042113	161	0.012	Mouse
stem cell development	GO:0048864	219	0.012
gtp metabolic process	GO:0046039	144	0.012
dna repair	GO:0006281	107	0.012
nucleocytoplasmic transport	GO:0006913	139	0.012
oogenesis	GO:0048477	56	0.012
carbohydrate derivative biosynthetic process	GO:1901137	183	0.012
protein processing	GO:0016485	163	0.012
t cell proliferation	GO:0042098	120	0.012	Mouse
digestive system development	GO:0055123	200	0.012
spinal cord development	GO:0021510	81	0.012
peptidyl lysine methylation	GO:0018022	29	0.012
response to gamma radiation	GO:0010332	22	0.012
regulation of anatomical structure size	GO:0090066	178	0.012
regulation of mitotic cell cycle phase transition	GO:1901990	73	0.012
smoothened signaling pathway	GO:0007224	105	0.012
negative regulation of cell proliferation	GO:0008285	296	0.012
nucleoside phosphate catabolic process	GO:1901292	222	0.012
negative regulation of nervous system development	GO:0051961	156	0.012
ribonucleoside metabolic process	GO:0009119	245	0.012
dna recombination	GO:0006310	92	0.012
locomotory behavior	GO:0007626	195	0.012
regulation of neural precursor cell proliferation	GO:2000177	70	0.011
chronological cell aging	GO:0001300	1	0.011
protein catabolic process	GO:0030163	221	0.011
cell adhesion	GO:0007155	329	0.011
cell cycle g1 s phase transition	GO:0044843	57	0.011
positive regulation of cell development	GO:0010720	237	0.011
regulation of cellular response to stress	GO:0080135	159	0.011
protein maturation	GO:0051604	176	0.011
regulation of intracellular protein transport	GO:0033157	82	0.011
purine nucleoside metabolic process	GO:0042278	241	0.011
rna 3 end processing	GO:0031123	20	0.011
transmembrane transport	GO:0055085	412	0.011
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.011
rna splicing via transesterification reactions with bulged adenosine as nucleophile	GO:0000377	43	0.011
ras protein signal transduction	GO:0007265	77	0.011
regulation of epithelial cell proliferation	GO:0050678	141	0.011
protein autophosphorylation	GO:0046777	61	0.011
meiotic nuclear division	GO:0007126	115	0.011
protein localization to organelle	GO:0033365	185	0.011
regulation of nucleoside metabolic process	GO:0009118	130	0.011
regulation of binding	GO:0051098	111	0.011
angiogenesis	GO:0001525	201	0.011
regulation of mrna splicing via spliceosome	GO:0048024	32	0.011
cytokine production	GO:0001816	319	0.011
stem cell division	GO:0017145	30	0.011	Mouse
organonitrogen compound biosynthetic process	GO:1901566	192	0.011
cilium assembly	GO:0042384	81	0.011
regulation of protein localization	GO:0032880	231	0.011
nuclear transport	GO:0051169	139	0.011
regulation of embryonic development	GO:0045995	71	0.011
negative regulation of cellular protein metabolic process	GO:0032269	247	0.011
negative regulation of mitotic cell cycle phase transition	GO:1901991	45	0.011
cellular lipid metabolic process	GO:0044255	323	0.011
maturation of lsu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna	GO:0000463	1	0.011
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.011
negative regulation of t helper 2 cell differentiation	GO:0045629	4	0.010
regulation of carbohydrate metabolic process	GO:0006109	75	0.010
neuron death	GO:0070997	154	0.010
multicellular organism growth	GO:0035264	161	0.010
ribonucleotide catabolic process	GO:0009261	208	0.010
regulation of defense response	GO:0031347	233	0.010
protein polymerization	GO:0051258	57	0.010
negative regulation of protein maturation	GO:1903318	79	0.010
ossification	GO:0001503	216	0.010
negative regulation of cell development	GO:0010721	169	0.010
regulation of production of molecular mediator of immune response	GO:0002700	65	0.010
wnt signaling pathway	GO:0016055	188	0.010
developmental growth involved in morphogenesis	GO:0060560	138	0.010
cellular response to peptide hormone stimulus	GO:0071375	92	0.010

Pcgf6 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
disease of cellular proliferation	DOID:14566	0.031
nervous system disease	DOID:863	0.028
disease of anatomical entity	DOID:7	0.028
cancer	DOID:162	0.022
organ system cancer	DOID:0050686	0.022
central nervous system disease	DOID:331	0.017
eye and adnexa disease	DOID:1492	0.014
eye disease	DOID:5614	0.014
sensory system disease	DOID:0050155	0.014
endocrine gland cancer	DOID:170	0.013

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