IMP: Integrative Multi-species Prediction

Mus musculus

329 known processes

Tnfsf11

tumor necrosis factor (ligand) superfamily, member 11

(Aliases: Trance,Ly109l,OPG,RANKL,OPGL,ODF)

Entrez: 21943
Ensembl: ENSMUSG00000022015
UniProtKB: O35235

Process Predictions
Disease Predictions

Tnfsf11 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
interleukin 10 secretion	GO:0072608	4	0.995
regulation of interleukin 10 secretion	GO:2001179	4	0.984
somatic diversification of immunoglobulins involved in immune response	GO:0002208	36	0.977	Mouse
positive regulation of lymphocyte mediated immunity	GO:0002708	62	0.942	Mouse
lymph node development	GO:0048535	18	0.935	Mouse
gland development	GO:0048732	330	0.916
positive regulation of inflammatory response	GO:0050729	47	0.902
regulation of acute inflammatory response	GO:0002673	27	0.899
metal ion homeostasis	GO:0055065	189	0.898
tissue remodeling	GO:0048771	102	0.889
interleukin 5 secretion	GO:0072603	2	0.877
positive regulation of translational initiation	GO:0045948	4	0.869	Mouse
epithelial cell proliferation	GO:0050673	174	0.849
regulation of leukocyte proliferation	GO:0070663	121	0.849
myeloid leukocyte differentiation	GO:0002573	119	0.847
innate immune response	GO:0045087	157	0.842	Fly
chemotaxis	GO:0006935	247	0.833	Human Mouse
extracellular structure organization	GO:0043062	148	0.831	Mouse
extrinsic apoptotic signaling pathway	GO:0097191	126	0.828	Mouse Fly
positive regulation of cell activation	GO:0050867	158	0.818	Human Mouse
somatic diversification of immunoglobulins	GO:0016445	43	0.807	Mouse
regulation of reactive oxygen species metabolic process	GO:2000377	40	0.804	Mouse
fever generation	GO:0001660	7	0.799
leukocyte differentiation	GO:0002521	342	0.796
cellular amino acid metabolic process	GO:0006520	103	0.790
negative regulation of interleukin 10 secretion	GO:2001180	2	0.789
icosanoid secretion	GO:0032309	12	0.788
ossification	GO:0001503	216	0.777
dna recombination	GO:0006310	92	0.777	Mouse
extracellular matrix organization	GO:0030198	147	0.766	Mouse
odontogenesis	GO:0042476	78	0.764
positive regulation of lymphocyte proliferation	GO:0050671	70	0.757
glial cell differentiation	GO:0010001	131	0.751
multicellular organismal homeostasis	GO:0048871	164	0.749
mammary gland alveolus development	GO:0060749	22	0.743
cellular response to amino acid stimulus	GO:0071230	29	0.734	Mouse
positive regulation of lipid transport	GO:0032370	22	0.709
osteoclast differentiation	GO:0030316	62	0.696
positive regulation of cytokine production	GO:0001819	174	0.695	Mouse
regulation of organ morphogenesis	GO:2000027	144	0.695	Mouse
corticotropin releasing hormone secretion	GO:0043396	2	0.693
myeloid cell differentiation	GO:0030099	233	0.685
t cell migration	GO:0072678	19	0.682	Mouse
morphogenesis of a branching epithelium	GO:0061138	193	0.679	Mouse
regulation of fatty acid transport	GO:2000191	10	0.677
branching morphogenesis of an epithelial tube	GO:0048754	159	0.676
morphogenesis of a branching structure	GO:0001763	203	0.673	Mouse
defense response to other organism	GO:0098542	197	0.672	Mouse Fly
acid secretion	GO:0046717	33	0.669
temperature homeostasis	GO:0001659	26	0.667
epithelial tube morphogenesis	GO:0060562	303	0.661
positive regulation of leukocyte proliferation	GO:0070665	73	0.660
sensory organ morphogenesis	GO:0090596	242	0.657	Mouse
positive regulation of interleukin 12 production	GO:0032735	21	0.657
lipid localization	GO:0010876	126	0.653
monocarboxylic acid transport	GO:0015718	44	0.649
regulation of b cell proliferation	GO:0030888	39	0.641
dna metabolic process	GO:0006259	303	0.629	Mouse
positive regulation of fever generation	GO:0031622	6	0.624
regulation of protein localization	GO:0032880	231	0.620	Mouse
regulation of protein transport	GO:0051223	163	0.616	Mouse
regulation of chronic inflammatory response to antigenic stimulus	GO:0002874	3	0.610	Mouse
t cell activation	GO:0042110	289	0.610	Human Mouse
regulation of jun kinase activity	GO:0043506	40	0.607
calcium ion homeostasis	GO:0055074	127	0.605
somatic recombination of immunoglobulin gene segments	GO:0016447	42	0.599	Mouse
leukocyte activation involved in immune response	GO:0002366	126	0.593	Mouse
positive regulation of sequence specific dna binding transcription factor activity	GO:0051091	68	0.593
dendritic cell differentiation	GO:0097028	26	0.575
intrinsic apoptotic signaling pathway in response to dna damage	GO:0008630	57	0.565	Mouse
positive regulation of organic acid transport	GO:0032892	11	0.561
regulation of lymphocyte mediated immunity	GO:0002706	84	0.560	Mouse
organic acid transport	GO:0015849	101	0.557
inflammatory response	GO:0006954	244	0.557
acute inflammatory response	GO:0002526	41	0.556
regulation of cytokine production	GO:0001817	266	0.549	Mouse
fatty acid transport	GO:0015908	28	0.548
response to organonitrogen compound	GO:0010243	246	0.546	Mouse
positive regulation of cell motility	GO:2000147	116	0.545	Mouse
regulation of organic acid transport	GO:0032890	16	0.541
interleukin 13 secretion	GO:0072611	2	0.537
b cell mediated immunity	GO:0019724	71	0.535	Mouse
carboxylic acid transport	GO:0046942	100	0.530
gliogenesis	GO:0042063	141	0.519
positive regulation of defense response	GO:0031349	124	0.517
positive regulation of icosanoid secretion	GO:0032305	7	0.516
positive regulation of innate immune response	GO:0045089	80	0.513
cytokine production	GO:0001816	319	0.512	Mouse
cellular amine metabolic process	GO:0044106	44	0.512
cellular response to biotic stimulus	GO:0071216	92	0.510	Mouse
regulation of cellular amine metabolic process	GO:0033238	20	0.508
regulation of cytokine secretion involved in immune response	GO:0002739	4	0.494
positive regulation of chronic inflammatory response	GO:0002678	4	0.494	Mouse
cellular calcium ion homeostasis	GO:0006874	119	0.491
positive regulation of translational initiation by iron	GO:0045994	2	0.485	Mouse
negative regulation of growth	GO:0045926	99	0.484	Mouse
somatic diversification of immune receptors	GO:0002200	53	0.480	Mouse
organic anion transport	GO:0015711	137	0.480
regulation of gliogenesis	GO:0014013	50	0.477
negative regulation of interleukin 5 production	GO:0032714	4	0.470
cell chemotaxis	GO:0060326	81	0.469	Human Mouse
fatty acid derivative transport	GO:1901571	14	0.468
cellular homeostasis	GO:0019725	240	0.466	Fly
regulation of anion transport	GO:0044070	27	0.463
regulation of leukocyte mediated immunity	GO:0002703	104	0.458	Mouse
amine metabolic process	GO:0009308	45	0.457
leukocyte migration	GO:0050900	124	0.451	Human Mouse
positive regulation of isotype switching to igg isotypes	GO:0048304	7	0.450
forebrain cell migration	GO:0021885	58	0.448
regulation of immunoglobulin production	GO:0002637	42	0.443	Mouse
positive regulation of cellular amine metabolic process	GO:0033240	5	0.441
cation homeostasis	GO:0055080	212	0.441
positive regulation of jun kinase activity	GO:0043507	30	0.439
cytokine mediated signaling pathway	GO:0019221	115	0.436
regulation of prostaglandin secretion	GO:0032306	5	0.434
positive regulation of apoptotic process	GO:0043065	217	0.434	Mouse
mammary gland lobule development	GO:0061377	22	0.432
regulation of hydrolase activity	GO:0051336	246	0.431	Mouse
hair cycle	GO:0042633	90	0.424	Mouse
cellular response to tumor necrosis factor	GO:0071356	21	0.423
cellular chemical homeostasis	GO:0055082	215	0.417
regulation of interleukin 13 secretion	GO:2000665	2	0.416
t cell differentiation	GO:0030217	174	0.414
positive regulation of fatty acid transport	GO:2000193	8	0.413
regulation of jnk cascade	GO:0046328	62	0.411
regulation of cytokine secretion	GO:0050707	61	0.408
cellular response to organonitrogen compound	GO:0071417	145	0.403	Mouse
negative regulation of cell proliferation	GO:0008285	296	0.401
calcium ion transport	GO:0006816	159	0.400
defense response to gram negative bacterium	GO:0050829	28	0.398	Fly
regulation of t cell activation	GO:0050863	170	0.396	Human Mouse
humoral immune response	GO:0006959	57	0.392	Mouse
somatic diversification of immune receptors via germline recombination within a single locus	GO:0002562	51	0.392	Mouse
telencephalon development	GO:0021537	186	0.390
positive regulation of prostaglandin secretion	GO:0032308	5	0.390
positive regulation of interferon gamma production	GO:0032729	39	0.389	Mouse
cellular response to molecule of bacterial origin	GO:0071219	83	0.386	Mouse
circadian rhythm	GO:0007623	114	0.386
regulation of cell activation	GO:0050865	289	0.385	Human Mouse
protein kinase b signaling	GO:0043491	74	0.384
immunoglobulin mediated immune response	GO:0016064	69	0.381	Mouse
response to molecule of bacterial origin	GO:0002237	143	0.381	Mouse
skeletal system development	GO:0001501	356	0.378
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002460	145	0.378	Mouse
lymphocyte proliferation	GO:0046651	164	0.377
regulation of myeloid cell differentiation	GO:0045637	96	0.375
positive regulation of leukocyte differentiation	GO:1902107	86	0.374
odontogenesis of dentin containing tooth	GO:0042475	66	0.373
cellular response to lipopolysaccharide	GO:0071222	77	0.372	Mouse
negative regulation of interleukin 13 secretion	GO:2000666	1	0.369
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.364
regulation of peptide secretion	GO:0002791	77	0.363
positive regulation of adaptive immune response	GO:0002821	61	0.360	Mouse
g protein coupled receptor signaling pathway	GO:0007186	243	0.357
b cell activation	GO:0042113	161	0.356	Mouse
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002824	61	0.356	Mouse
regulation of epithelial cell proliferation	GO:0050678	141	0.355
anion transport	GO:0006820	177	0.348
positive regulation of fever generation by positive regulation of prostaglandin secretion	GO:0071812	2	0.347
hair follicle development	GO:0001942	85	0.341	Mouse
immunoglobulin secretion	GO:0048305	17	0.339	Mouse
lipid transport	GO:0006869	98	0.333
immunoglobulin production involved in immunoglobulin mediated immune response	GO:0002381	43	0.332	Mouse
t cell proliferation	GO:0042098	120	0.330
cellular ion homeostasis	GO:0006873	165	0.329
mammary gland epithelium development	GO:0061180	65	0.327
regulation of odontogenesis	GO:0042481	18	0.326
apoptotic signaling pathway	GO:0097190	306	0.322	Mouse Fly
b cell activation involved in immune response	GO:0002312	50	0.321	Mouse
positive regulation of osteoclast differentiation	GO:0045672	15	0.320
regulation of peptide hormone secretion	GO:0090276	75	0.320
regulation of sequence specific dna binding transcription factor activity	GO:0051090	106	0.317
regionalization	GO:0003002	337	0.316
immune response activating cell surface receptor signaling pathway	GO:0002429	72	0.313
adaptive immune response	GO:0002250	155	0.312	Mouse
isotype switching	GO:0045190	36	0.312	Mouse
leukocyte mediated immunity	GO:0002443	174	0.310	Mouse
positive regulation of heat generation	GO:0031652	7	0.309
axon ensheathment	GO:0008366	76	0.308
negative regulation of odontogenesis of dentin containing tooth	GO:0042489	1	0.307
posttranscriptional regulation of gene expression	GO:0010608	155	0.307	Mouse
somatic cell dna recombination	GO:0016444	51	0.306	Mouse
regulation of secretion by cell	GO:1903530	249	0.305
positive regulation of protein phosphorylation	GO:0001934	242	0.303
t cell differentiation in thymus	GO:0033077	77	0.301
blood vessel morphogenesis	GO:0048514	285	0.300
regulation of morphogenesis of a branching structure	GO:0060688	53	0.300	Mouse
regulation of cellular amino acid metabolic process	GO:0006521	5	0.299
cytokine production involved in immune response	GO:0002367	34	0.295
lymphocyte mediated immunity	GO:0002449	139	0.292	Mouse
cellular response to acid chemical	GO:0071229	68	0.290	Mouse
positive regulation of reactive oxygen species biosynthetic process	GO:1903428	2	0.289
regulation of protein kinase activity	GO:0045859	232	0.287
regulation of interleukin 5 secretion	GO:2000662	2	0.286
ameboidal type cell migration	GO:0001667	128	0.285
regulation of fever generation by regulation of prostaglandin secretion	GO:0071810	2	0.284
cellular response to dna damage stimulus	GO:0006974	207	0.282	Mouse
inflammatory response to antigenic stimulus	GO:0002437	30	0.275	Mouse
regulation of icosanoid secretion	GO:0032303	8	0.275
skeletal system morphogenesis	GO:0048705	203	0.272
somatic recombination of immunoglobulin genes involved in immune response	GO:0002204	36	0.272	Mouse
regulation of defense response	GO:0031347	233	0.271
regulation of lymphocyte proliferation	GO:0050670	117	0.269
positive regulation of protein serine threonine kinase activity	GO:0071902	106	0.267
tumor necrosis factor mediated signaling pathway	GO:0033209	13	0.266
lymphocyte migration	GO:0072676	26	0.265	Mouse
sensory perception	GO:0007600	245	0.265
icosanoid transport	GO:0071715	14	0.265
stem cell development	GO:0048864	219	0.263
cellular divalent inorganic cation homeostasis	GO:0072503	127	0.260
defense response to bacterium	GO:0042742	119	0.260	Mouse Fly
reactive oxygen species metabolic process	GO:0072593	84	0.258	Mouse
cell fate commitment	GO:0045165	210	0.255	Fly
cytokine secretion involved in immune response	GO:0002374	6	0.255
peptide secretion	GO:0002790	114	0.255
regulation of cellular ketone metabolic process	GO:0010565	66	0.249
positive regulation of cytokine secretion involved in immune response	GO:0002741	2	0.247
positive regulation of lymphocyte activation	GO:0051251	140	0.247	Human Mouse
pallium development	GO:0021543	120	0.246
b cell differentiation	GO:0030183	78	0.245	Mouse
peptidyl amino acid modification	GO:0018193	336	0.245
regulation of oligodendrocyte differentiation	GO:0048713	23	0.245
regulation of cysteine type endopeptidase activity	GO:2000116	65	0.244	Mouse
positive regulation of ion transport	GO:0043270	65	0.242
muscle tissue development	GO:0060537	308	0.242	Mouse
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.241
reactive nitrogen species metabolic process	GO:2001057	0	0.239
regulation of secretion	GO:0051046	274	0.238
heat generation	GO:0031649	13	0.238
ensheathment of neurons	GO:0007272	76	0.238
cellular ketone metabolic process	GO:0042180	84	0.237
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002822	87	0.234	Mouse
regulation of t cell proliferation	GO:0042129	92	0.232
epidermis development	GO:0008544	187	0.231	Mouse
transmission of nerve impulse	GO:0019226	76	0.230
intrinsic apoptotic signaling pathway	GO:0097193	132	0.229	Mouse
myeloid dendritic cell differentiation	GO:0043011	16	0.228
immune effector process	GO:0002252	321	0.227	Mouse
antibacterial peptide production	GO:0002778	2	0.227
lymphocyte differentiation	GO:0030098	242	0.225	Mouse
negative regulation of interleukin 5 secretion	GO:2000663	1	0.225
mapk cascade	GO:0000165	281	0.224
rhythmic process	GO:0048511	174	0.223
regulation of b cell activation	GO:0050864	81	0.223
positive regulation of protein transport	GO:0051222	93	0.223	Mouse
mesenchyme development	GO:0060485	152	0.221
positive regulation of mapk cascade	GO:0043410	170	0.221
production of molecular mediator of immune response	GO:0002440	103	0.221	Mouse
myeloid dendritic cell activation	GO:0001773	25	0.220
positive regulation of myoblast differentiation	GO:0045663	8	0.220	Mouse
regulation of b cell mediated immunity	GO:0002712	37	0.218	Mouse
positive regulation of immunoglobulin mediated immune response	GO:0002891	26	0.218	Mouse
anatomical structure homeostasis	GO:0060249	145	0.217
divalent inorganic cation transport	GO:0072511	178	0.217
positive regulation of b cell proliferation	GO:0030890	24	0.216
camera type eye development	GO:0043010	266	0.215
regulation of inflammatory response to antigenic stimulus	GO:0002861	21	0.215	Mouse
response to extracellular stimulus	GO:0009991	127	0.214
glial cell apoptotic process	GO:0034349	3	0.213
forebrain development	GO:0030900	302	0.213
positive regulation of chronic inflammatory response to antigenic stimulus	GO:0002876	2	0.211	Mouse
acute phase response	GO:0006953	10	0.211
regulation of reactive oxygen species biosynthetic process	GO:1903426	2	0.210
alpha beta t cell differentiation	GO:0046632	69	0.209
defense response to gram positive bacterium	GO:0050830	50	0.209	Mouse
molting cycle	GO:0042303	90	0.208	Mouse
regulation of establishment of protein localization	GO:0070201	181	0.208	Mouse
mesenchymal cell differentiation	GO:0048762	107	0.206
regulation of immunoglobulin secretion	GO:0051023	12	0.206	Mouse
lung development	GO:0030324	164	0.206
hexose metabolic process	GO:0019318	98	0.204	Mouse
positive regulation of apoptotic signaling pathway	GO:2001235	95	0.203
regulation of osteoclast differentiation	GO:0045670	36	0.202
regulation of odontogenesis of dentin containing tooth	GO:0042487	11	0.201
leukocyte chemotaxis	GO:0030595	69	0.201	Human Mouse
protein processing	GO:0016485	163	0.201	Mouse
alpha beta t cell proliferation	GO:0046633	21	0.200
reactive oxygen species biosynthetic process	GO:1903409	8	0.200
positive regulation of hydrolase activity	GO:0051345	148	0.200	Mouse
cell type specific apoptotic process	GO:0097285	268	0.199
regulation of response to wounding	GO:1903034	189	0.198
amide transport	GO:0042886	138	0.197
positive regulation of chemotaxis	GO:0050921	38	0.196	Mouse
positive regulation of protein kinase b signaling	GO:0051897	32	0.195
negative regulation of interleukin 13 production	GO:0032696	2	0.195
positive regulation of cytoplasmic transport	GO:1903651	40	0.194	Mouse
placenta development	GO:0001890	140	0.193
regulation of cell migration	GO:0030334	219	0.193	Mouse
liver development	GO:0001889	66	0.191
regulation of inflammatory response	GO:0050727	147	0.191
t cell receptor signaling pathway	GO:0050852	46	0.191
regulation of lymphocyte migration	GO:2000401	14	0.190	Mouse
regulation of lipid transport	GO:0032368	36	0.188
positive regulation of macrophage derived foam cell differentiation	GO:0010744	4	0.188
positive regulation of glial cell proliferation	GO:0060252	4	0.187
lymphocyte activation involved in immune response	GO:0002285	93	0.186	Mouse
immune response activating signal transduction	GO:0002757	116	0.184
divalent inorganic cation homeostasis	GO:0072507	138	0.183
regulation of immunoglobulin mediated immune response	GO:0002889	37	0.182	Mouse
respiratory tube development	GO:0030323	167	0.182
osteoclast proliferation	GO:0002158	4	0.181
response to amino acid	GO:0043200	37	0.180	Mouse
positive regulation of programmed cell death	GO:0043068	218	0.179	Mouse
antimicrobial peptide production	GO:0002775	2	0.179
jnk cascade	GO:0007254	72	0.176
prostaglandin secretion	GO:0032310	5	0.176
antibacterial peptide biosynthetic process	GO:0002780	2	0.175
regulation of protein serine threonine kinase activity	GO:0071900	157	0.174
cellular response to abiotic stimulus	GO:0071214	56	0.174
immunoglobulin production	GO:0002377	73	0.173	Mouse
positive regulation of b cell activation	GO:0050871	49	0.173
regulation of protein secretion	GO:0050708	82	0.172	Mouse
leukocyte proliferation	GO:0070661	172	0.172
negative regulation of ossification	GO:0030279	49	0.171	Mouse
mammary gland epithelial cell proliferation	GO:0033598	24	0.171
regulation of innate immune response	GO:0045088	91	0.171
activation of innate immune response	GO:0002218	56	0.170
regulation of cell motility	GO:2000145	236	0.169	Mouse
negative regulation of growth of symbiont in host	GO:0044130	19	0.168	Mouse
positive regulation of syncytium formation by plasma membrane fusion	GO:0060143	17	0.168	Mouse
positive regulation of map kinase activity	GO:0043406	84	0.167
response to lipopolysaccharide	GO:0032496	128	0.167	Mouse
negative regulation of extrinsic apoptotic signaling pathway	GO:2001237	45	0.167
telencephalon cell migration	GO:0022029	55	0.166
regulation of dna recombination	GO:0000018	34	0.165
purine ribonucleoside metabolic process	GO:0046128	241	0.164
response to acid chemical	GO:0001101	111	0.164	Mouse
erk1 and erk2 cascade	GO:0070371	77	0.162
regulation of extrinsic apoptotic signaling pathway	GO:2001236	77	0.162
cytokine secretion	GO:0050663	72	0.162
protein secretion	GO:0009306	111	0.162	Mouse
protein localization to nucleus	GO:0034504	121	0.161	Mouse
positive regulation of cell migration	GO:0030335	109	0.161	Mouse
regulation of canonical wnt signaling pathway	GO:0060828	82	0.159
regulation of monocyte chemotaxis	GO:0090025	3	0.159
stress activated mapk cascade	GO:0051403	80	0.159
cytosolic calcium ion homeostasis	GO:0051480	70	0.158
multicellular organismal signaling	GO:0035637	91	0.157
response to nutrient levels	GO:0031667	109	0.156
fat cell differentiation	GO:0045444	160	0.156
negative regulation of nervous system development	GO:0051961	156	0.155
ras protein signal transduction	GO:0007265	77	0.155
positive regulation of myeloid cell differentiation	GO:0045639	43	0.154
cation transport	GO:0006812	399	0.153
regulation of lymphocyte differentiation	GO:0045619	107	0.153
spleen development	GO:0048536	39	0.153
regulation of membrane potential	GO:0042391	192	0.153
digestive tract development	GO:0048565	190	0.152
bone remodeling	GO:0046849	53	0.152
protein targeting	GO:0006605	143	0.151	Mouse
response to decreased oxygen levels	GO:0036293	59	0.150
regulation of hormone levels	GO:0010817	211	0.149
regulation of intracellular transport	GO:0032386	159	0.149	Mouse
regulation of translational initiation	GO:0006446	15	0.149	Mouse
cell activation involved in immune response	GO:0002263	126	0.148	Mouse
regulation of vasculature development	GO:1901342	88	0.148
positive regulation of t cell proliferation	GO:0042102	52	0.148
positive regulation of immune effector process	GO:0002699	107	0.148	Mouse
neural tube development	GO:0021915	160	0.147
cellular protein catabolic process	GO:0044257	155	0.147
chronic inflammatory response to antigenic stimulus	GO:0002439	3	0.147	Mouse
regulation of wnt signaling pathway	GO:0030111	123	0.146
negative regulation of osteoblast differentiation	GO:0045668	30	0.146	Mouse
interleukin 12 production	GO:0032615	32	0.146
necroptotic process	GO:0070266	21	0.146	Mouse
regulation of growth of symbiont in host	GO:0044126	19	0.144	Mouse
hepaticobiliary system development	GO:0061008	67	0.144
regulation of glial cell differentiation	GO:0045685	41	0.144
myeloid leukocyte activation	GO:0002274	83	0.143
regulation of ion transport	GO:0043269	215	0.143
regulation of translational initiation by iron	GO:0006447	2	0.142	Mouse
response to tumor necrosis factor	GO:0034612	26	0.140
translation	GO:0006412	93	0.139	Mouse
regulation of peptide transport	GO:0090087	91	0.138
renal system development	GO:0072001	225	0.137
respiratory system development	GO:0060541	190	0.136
cellular metal ion homeostasis	GO:0006875	151	0.136
positive regulation of acute inflammatory response	GO:0002675	16	0.136
oligodendrocyte differentiation	GO:0048709	53	0.135
neuronal action potential	GO:0019228	54	0.135
macromolecule catabolic process	GO:0009057	281	0.134
negative regulation of defense response	GO:0031348	77	0.134
positive regulation of cytokine secretion	GO:0050715	41	0.132
regulation of branching involved in salivary gland morphogenesis	GO:0060693	11	0.132	Mouse
positive regulation of leukocyte mediated cytotoxicity	GO:0001912	31	0.131
bone resorption	GO:0045453	38	0.130
protein import	GO:0017038	101	0.129	Mouse
digestive tract morphogenesis	GO:0048546	147	0.129
positive regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043280	36	0.128	Mouse
antigen processing and presentation	GO:0019882	47	0.126
positive regulation of cysteine type endopeptidase activity	GO:2001056	39	0.126	Mouse
negative regulation of phosphate metabolic process	GO:0045936	184	0.126	Mouse
cytoplasmic transport	GO:0016482	234	0.125	Mouse
positive regulation of t cell activation	GO:0050870	101	0.124	Human Mouse
positive regulation of cd8 positive alpha beta t cell extravasation	GO:2000451	2	0.124
positive regulation of response to wounding	GO:1903036	66	0.122
defense response to virus	GO:0051607	68	0.122
peptide hormone secretion	GO:0030072	109	0.122
regulation of neuron differentiation	GO:0045664	281	0.121
circadian temperature homeostasis	GO:0060086	2	0.121
regulation of mapk cascade	GO:0043408	248	0.121
positive regulation of osteoclast development	GO:2001206	3	0.121
regulation of cytoplasmic transport	GO:1903649	112	0.121	Mouse
regulation of homeostatic process	GO:0032844	182	0.120
positive regulation of myeloid leukocyte differentiation	GO:0002763	26	0.119
regulation of corticotropin releasing hormone secretion	GO:0043397	2	0.118
glucose transport	GO:0015758	56	0.118	Mouse
connective tissue development	GO:0061448	179	0.117
negative regulation of leukocyte proliferation	GO:0070664	46	0.117
negative regulation of b cell proliferation	GO:0030889	13	0.116
pattern recognition receptor signaling pathway	GO:0002221	47	0.116
epithelial to mesenchymal transition	GO:0001837	47	0.115
extrinsic apoptotic signaling pathway in absence of ligand	GO:0097192	55	0.115
positive regulation of oligodendrocyte differentiation	GO:0048714	9	0.114
regulation of kinase activity	GO:0043549	249	0.114
branching involved in mammary gland duct morphogenesis	GO:0060444	27	0.113
response to peptide	GO:1901652	136	0.112
developmental growth involved in morphogenesis	GO:0060560	138	0.112
positive regulation of cytokine production involved in immune response	GO:0002720	19	0.112
developmental programmed cell death	GO:0010623	41	0.111	Mouse
central nervous system neuron differentiation	GO:0021953	162	0.110
organic hydroxy compound metabolic process	GO:1901615	203	0.110	Fly
regulation of leukocyte differentiation	GO:1902105	159	0.110
hormone secretion	GO:0046879	128	0.109
cellular response to peptide	GO:1901653	92	0.108
peptidyl tyrosine modification	GO:0018212	145	0.108
peptidyl tyrosine phosphorylation	GO:0018108	143	0.106
kidney development	GO:0001822	213	0.106
regulation of translation	GO:0006417	71	0.105	Mouse
regulation of lymphocyte activation	GO:0051249	240	0.104	Human Mouse
regulation of apoptotic signaling pathway	GO:2001233	197	0.104
cellular response to peptide hormone stimulus	GO:0071375	92	0.102
cytokine biosynthetic process	GO:0042089	68	0.102
b cell apoptotic process	GO:0001783	19	0.101
regulation of cytoskeleton organization	GO:0051493	122	0.101
positive regulation of t cell costimulation	GO:2000525	2	0.100
steroid metabolic process	GO:0008202	119	0.100
purine ribonucleoside catabolic process	GO:0046130	205	0.100
mesenchymal cell development	GO:0014031	93	0.100
regulation of interleukin 12 production	GO:0032655	30	0.099
appendage morphogenesis	GO:0035107	149	0.099
digestive system development	GO:0055123	200	0.099
positive regulation of cytokine biosynthetic process	GO:0042108	40	0.099
eosinophil degranulation	GO:0043308	1	0.098
regulation of map kinase activity	GO:0043405	120	0.098
mammary gland morphogenesis	GO:0060443	54	0.096
positive regulation of protein modification process	GO:0031401	299	0.095
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.095
skin development	GO:0043588	220	0.095	Mouse
myotube differentiation	GO:0014902	105	0.095	Mouse
carbohydrate derivative biosynthetic process	GO:1901137	183	0.095
membrane organization	GO:0061024	245	0.094	Fly
stress activated protein kinase signaling cascade	GO:0031098	81	0.094
cellular response to external stimulus	GO:0071496	88	0.094
maternal placenta development	GO:0001893	20	0.093
regulation of cellular response to stress	GO:0080135	159	0.093
stem cell differentiation	GO:0048863	268	0.092
single organism cell adhesion	GO:0098602	156	0.092	Human
prostaglandin transport	GO:0015732	7	0.091
negative regulation of t cell activation	GO:0050868	65	0.091
myd88 independent toll like receptor signaling pathway	GO:0002756	3	0.090
appendage development	GO:0048736	166	0.090
activation of jun kinase activity	GO:0007257	15	0.090
t cell extravasation	GO:0072683	4	0.090
regulation of fever generation	GO:0031620	6	0.089
cerebral cortex development	GO:0021987	86	0.089
small molecule biosynthetic process	GO:0044283	132	0.089
embryonic organ morphogenesis	GO:0048562	276	0.088
positive regulation of erk1 and erk2 cascade	GO:0070374	47	0.087	Human
positive regulation of monocyte chemotaxis	GO:0090026	2	0.087
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.087
regulation of cell cycle	GO:0051726	281	0.087
cellular response to lipid	GO:0071396	145	0.086	Mouse
regulation of protein localization to nucleus	GO:1900180	60	0.086	Mouse
necroptotic signaling pathway	GO:0097527	3	0.086	Mouse
cellular response to cytokine stimulus	GO:0071345	189	0.086
guanosine containing compound metabolic process	GO:1901068	144	0.086
regulation of interleukin 10 production	GO:0032653	21	0.086
negative regulation of cytokine production	GO:0001818	84	0.086
canonical wnt signaling pathway	GO:0060070	130	0.085
negative regulation of alpha beta t cell activation	GO:0046636	18	0.085
single organism nuclear import	GO:1902593	95	0.085	Mouse
negative regulation of cell development	GO:0010721	169	0.085
regulation of cytokine production involved in immune response	GO:0002718	26	0.084
regulation of peptidyl tyrosine phosphorylation	GO:0050730	93	0.084
antimicrobial peptide biosynthetic process	GO:0002777	2	0.084
mitotic cell cycle	GO:0000278	195	0.083
regulation of myeloid leukocyte differentiation	GO:0002761	58	0.083
negative regulation of growth of symbiont involved in interaction with host	GO:0044146	19	0.082	Mouse
alpha beta t cell activation involved in immune response	GO:0002287	31	0.082
regulation of alpha beta t cell proliferation	GO:0046640	18	0.082
immune response regulating cell surface receptor signaling pathway	GO:0002768	80	0.082
forebrain generation of neurons	GO:0021872	63	0.082
epidermis morphogenesis	GO:0048730	33	0.081

Tnfsf11 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability	Func Analog Org
disease of anatomical entity	DOID:7	0.849	Human
musculoskeletal system disease	DOID:17	0.849	Human
connective tissue disease	DOID:65	0.733	Human
bone remodeling disease	DOID:0080005	0.661	Human
bone disease	DOID:0080001	0.661	Human

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