Mus musculus

11 known processes

Gsdmd

gasdermin D

(Aliases: AW558049,M2-4,DF5L,1810036L03Rik,Dfna5l,Gsdmdc1)

Gsdmd biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
immune effector processGO:00022523210.218
heterocycle catabolic processGO:00467002800.166
regulation of innate immune responseGO:0045088910.161
organic cyclic compound catabolic processGO:19013612950.147
regulation of hydrolase activityGO:00513362460.137
purine containing compound metabolic processGO:00725213110.120
nucleobase containing small molecule metabolic processGO:00550863520.117
cellular nitrogen compound catabolic processGO:00442702800.109
cell activation involved in immune responseGO:00022631260.108
innate immune responseGO:00450871570.106
interspecies interaction between organismsGO:0044419830.102
regulation of cytokine productionGO:00018172660.102
negative regulation of multi organism processGO:0043901680.101
aromatic compound catabolic processGO:00194392860.097
activation of immune responseGO:00022531380.096
regulation of defense responseGO:00313472330.095
glycosyl compound metabolic processGO:19016572460.094
ribonucleoside metabolic processGO:00091192450.094
positive regulation of innate immune responseGO:0045089800.088
ras protein signal transductionGO:0007265770.084
nucleotide metabolic processGO:00091173320.081
ribose phosphate metabolic processGO:00196932910.079
defense response to other organismGO:00985421970.077
purine ribonucleoside triphosphate metabolic processGO:00092052200.076
nucleoside phosphate metabolic processGO:00067533380.074
purine ribonucleotide catabolic processGO:00091542080.073
leukocyte differentiationGO:00025213420.073
positive regulation of programmed cell deathGO:00430682180.072
Mouse
positive regulation of cell deathGO:00109422240.072
Mouse
viral processGO:0016032410.072
response to molecule of bacterial originGO:00022371430.071
regulation of organelle organizationGO:00330432890.071
ribonucleoside catabolic processGO:00424542060.070
macromolecule catabolic processGO:00090572810.069
purine nucleotide metabolic processGO:00061633020.068
activation of innate immune responseGO:0002218560.068
lymphocyte mediated immunityGO:00024491390.067
leukocyte proliferationGO:00706611720.065
cytokine productionGO:00018163190.065
symbiosis encompassing mutualism through parasitismGO:0044403830.064
cellular response to dna damage stimulusGO:00069742070.062
response to lipopolysaccharideGO:00324961280.061
positive regulation of hydrolase activityGO:00513451480.059
immune response activating signal transductionGO:00027571160.058
nucleoside metabolic processGO:00091162460.057
lymphocyte activation involved in immune responseGO:0002285930.057
purine ribonucleoside triphosphate catabolic processGO:00092071990.057
cell adhesionGO:00071553290.056
carbohydrate derivative catabolic processGO:19011362310.055
ribonucleotide metabolic processGO:00092592910.054
positive regulation of apoptotic processGO:00430652170.051
Mouse
cellular macromolecule catabolic processGO:00442652060.051
ribonucleoside triphosphate metabolic processGO:00091992200.051
immune response regulating signaling pathwayGO:00027641250.051
purine containing compound catabolic processGO:00725232130.050
regulation of cellular component biogenesisGO:00440871810.050
ribonucleoside triphosphate catabolic processGO:00092031990.049
small gtpase mediated signal transductionGO:0007264970.049
regulation of cellular amino acid metabolic processGO:000652150.049
purine ribonucleoside catabolic processGO:00461302050.049
homeostasis of number of cellsGO:00488722100.048
leukocyte activation involved in immune responseGO:00023661260.047
t cell activation involved in immune responseGO:0002286430.047
positive regulation of defense responseGO:00313491240.047
dna metabolic processGO:00062593030.046
myeloid leukocyte differentiationGO:00025731190.046
gland developmentGO:00487323300.046
Mouse
cellular amine metabolic processGO:0044106440.046
purine ribonucleoside metabolic processGO:00461282410.045
negative regulation of lymphocyte activationGO:0051250910.045
negative regulation of immune system processGO:00026832090.043
regulation of multi organism processGO:00439001110.042
regulation of purine nucleotide catabolic processGO:00331211220.042
nucleoside phosphate catabolic processGO:19012922220.041
guanosine containing compound metabolic processGO:19010681440.040
t cell activationGO:00421102890.040
nucleoside catabolic processGO:00091642060.040
cation transportGO:00068123990.040
purine ribonucleotide metabolic processGO:00091502900.040
leukocyte mediated immunityGO:00024431740.039
myeloid cell differentiationGO:00300992330.039
transmembrane transportGO:00550854120.039
cellular amino acid metabolic processGO:00065201030.039
purine nucleotide catabolic processGO:00061952110.038
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:00024601450.038
nucleoside triphosphate metabolic processGO:00091412300.038
negative regulation of molecular functionGO:00440922580.037
regulation of ras protein signal transductionGO:00465781140.037
regulation of purine nucleotide metabolic processGO:19005421690.037
posttranscriptional regulation of gene expressionGO:00106081550.037
regulation of proteolysisGO:00301621640.037
response to organic cyclic compoundGO:00140701980.036
cellular ketone metabolic processGO:0042180840.036
regulation of protein localizationGO:00328802310.036
cellular response to lipopolysaccharideGO:0071222770.036
positive regulation of type i interferon productionGO:0032481140.036
purine nucleoside triphosphate catabolic processGO:00091462030.036
protein modification by small protein conjugation or removalGO:00706472070.036
carbohydrate metabolic processGO:00059752300.035
ion transmembrane transportGO:00342203610.035
cell type specific apoptotic processGO:00972852680.034
chromatin organizationGO:00063252060.034
negative regulation of protein metabolic processGO:00512482820.034
organophosphate catabolic processGO:00464342320.034
regulation of cellular ketone metabolic processGO:0010565660.033
cellular response to cytokine stimulusGO:00713451890.033
regulation of symbiosis encompassing mutualism through parasitismGO:0043903520.033
glycosyl compound catabolic processGO:19016582060.033
regulation of cellular catabolic processGO:00313292420.033
muscle cell differentiationGO:00426922610.033
pattern recognition receptor signaling pathwayGO:0002221470.033
histone modificationGO:00165701590.033
cellular response to biotic stimulusGO:0071216920.033
negative regulation of viral genome replicationGO:0045071100.032
negative regulation of cellular component organizationGO:00511291940.032
regulation of cellular amine metabolic processGO:0033238200.031
ribonucleotide catabolic processGO:00092612080.031
purine nucleoside metabolic processGO:00422782410.031
stem cell differentiationGO:00488632680.031
Mouse
mapk cascadeGO:00001652810.031
lymphocyte proliferationGO:00466511640.030
purine nucleoside triphosphate metabolic processGO:00091442260.030
protein maturationGO:00516041760.030
protein catabolic processGO:00301632210.030
organonitrogen compound biosynthetic processGO:19015661920.029
protein ubiquitinationGO:00165671710.029
regulation of leukocyte proliferationGO:00706631210.029
purine nucleoside catabolic processGO:00061522050.029
positive regulation of purine nucleotide metabolic processGO:19005441140.029
peptidyl amino acid modificationGO:00181933360.029
regulation of nucleotide metabolic processGO:00061401690.029
positive regulation of kinase activityGO:00336741550.028
positive regulation of cellular catabolic processGO:00313311480.028
regulation of lymphocyte activationGO:00512492400.028
alpha beta t cell differentiationGO:0046632690.028
proteolysis involved in cellular protein catabolic processGO:00516031470.028
guanosine containing compound catabolic processGO:19010691440.027
reactive oxygen species metabolic processGO:0072593840.027
response to radiationGO:00093141650.027
positive regulation of cytokine productionGO:00018191740.027
defense response to bacteriumGO:00427421190.027
leukocyte mediated cytotoxicityGO:0001909620.027
nucleoside triphosphate catabolic processGO:00091432050.027
epithelial cell proliferationGO:00506731740.026
cellular response to lipidGO:00713961450.026
epidermis developmentGO:00085441870.026
Mouse
regulation of membrane potentialGO:00423911920.026
gtp catabolic processGO:00061841430.026
positive regulation of cellular amino acid metabolic processGO:004576430.026
positive regulation of nucleotide catabolic processGO:0030813880.026
gtp metabolic processGO:00460391440.026
negative regulation of cell activationGO:00508661110.026
learning or memoryGO:00076111480.025
chromatin modificationGO:00165681870.025
regulation of leukocyte differentiationGO:19021051590.025
protein modification by small protein conjugationGO:00324461870.025
male gamete generationGO:00482322850.025
spermatogenesisGO:00072832840.025
nitrogen compound transportGO:00717052710.024
lymphocyte homeostasisGO:0002260640.024
regulation of nucleotide catabolic processGO:00308111220.024
positive regulation of cellular amine metabolic processGO:003324050.024
negative regulation of cellular amine metabolic processGO:003323910.024
viral life cycleGO:0019058360.024
t cell proliferationGO:00420981200.024
regulation of cell activationGO:00508652890.023
negative regulation of cell proliferationGO:00082852960.023
positive regulation of immune effector processGO:00026991070.023
muscle tissue developmentGO:00605373080.023
interleukin 1 productionGO:0032612310.023
monocarboxylic acid metabolic processGO:00327871910.023
regulation of secretion by cellGO:19035302490.023
nucleotide catabolic processGO:00091662170.023
cytoplasmic transportGO:00164822340.023
regulation of adaptive immune responseGO:0002819900.023
regulation of inflammatory responseGO:00507271470.023
regulation of leukocyte mediated immunityGO:00027031040.023
cytokine mediated signaling pathwayGO:00192211150.023
regulation of kinase activityGO:00435492490.023
modification dependent macromolecule catabolic processGO:00436321330.023
leukocyte homeostasisGO:0001776790.022
cellular protein catabolic processGO:00442571550.022
positive regulation of nucleotide metabolic processGO:00459811140.022
rna interferenceGO:001624620.022
microtubule based processGO:00070172360.022
regulation of hormone levelsGO:00108172110.022
positive regulation of proteolysisGO:0045862850.022
regulation of cell migrationGO:00303342190.022
regulation of peptidase activityGO:0052547960.021
intracellular protein transportGO:00068862040.021
type i interferon productionGO:0032606290.021
positive regulation of interferon alpha productionGO:003272740.021
positive regulation of gtp catabolic processGO:0033126850.021
membrane organizationGO:00610242450.021
defense response to virusGO:0051607680.021
inflammatory responseGO:00069542440.021
cellular response to organonitrogen compoundGO:00714171450.021
organonitrogen compound catabolic processGO:19015652640.021
inorganic ion transmembrane transportGO:00986602340.021
multicellular organismal homeostasisGO:00488711640.021
regulation of ion transportGO:00432692150.020
lymphocyte differentiationGO:00300982420.020
actin cytoskeleton organizationGO:00300362200.020
b cell mediated immunityGO:0019724710.020
regulation of protein transportGO:00512231630.020
covalent chromatin modificationGO:00165691630.020
regulation of cell motilityGO:20001452360.020
cellular response to molecule of bacterial originGO:0071219830.020
modification dependent protein catabolic processGO:00199411330.020
interferon beta biosynthetic processGO:004535040.020
microtubule cytoskeleton organizationGO:00002261570.020
cognitionGO:00508901490.020
reactive nitrogen species metabolic processGO:200105700.020
endocytosisGO:00068971680.019
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043281620.019
regulation of endopeptidase activityGO:0052548890.019
apoptotic signaling pathwayGO:00971903060.019
Mouse
regulation of interferon beta biosynthetic processGO:004535740.019
rho protein signal transductionGO:0007266320.019
negative regulation of phosphorus metabolic processGO:00105631840.019
positive regulation of protein modification processGO:00314012990.019
production of molecular mediator of immune responseGO:00024401030.019
positive regulation of cell projection organizationGO:0031346950.019
amine metabolic processGO:0009308450.019
viral genome replicationGO:0019079170.019
positive regulation of purine nucleotide catabolic processGO:0033123880.019
regulation of t cell activationGO:00508631700.018
protein localization to organelleGO:00333651850.018
protein autophosphorylationGO:0046777610.018
skin developmentGO:00435882200.018
Mouse
skeletal system developmentGO:00015013560.018
protein localization to membraneGO:00726571080.018
response to organonitrogen compoundGO:00102432460.018
regulation of t cell proliferationGO:0042129920.018
regulation of reactive oxygen species biosynthetic processGO:190342620.018
regulation of secretionGO:00510462740.018
positive regulation of lymphocyte activationGO:00512511400.018
nucleotide biosynthetic processGO:0009165780.018
positive regulation of gtpase activityGO:0043547850.018
regulation of cytoskeleton organizationGO:00514931220.017
glial cell apoptotic processGO:003434930.017
regulation of cell adhesionGO:00301551540.017
regulation of cell cycleGO:00517262810.017
cell killingGO:0001906670.017
negative regulation of cytokine productionGO:0001818840.017
organelle assemblyGO:00709251770.017
nucleocytoplasmic transportGO:00069131390.017
divalent metal ion transportGO:00708381720.017
regulation of nucleoside metabolic processGO:00091181300.017
anatomical structure homeostasisGO:00602491450.017
calcium ion transportGO:00068161590.017
carbohydrate homeostasisGO:00335001280.017
organophosphate biosynthetic processGO:00904071220.017
purine nucleotide biosynthetic processGO:0006164650.017
regulation of cell projection organizationGO:00313442060.017
learningGO:0007612980.016
maintenance of locationGO:0051235890.016
regulation of mapk cascadeGO:00434082480.016
response to growth factorGO:00708481980.016
carbohydrate derivative biosynthetic processGO:19011371830.016
purine containing compound biosynthetic processGO:0072522700.016
regulation of gtp catabolic processGO:00331241130.016
cellular response to organic cyclic compoundGO:0071407870.016
negative regulation of leukocyte differentiationGO:1902106510.016
endomembrane system organizationGO:00102561470.016
protein processingGO:00164851630.016
b cell activation involved in immune responseGO:0002312500.016
adaptive immune responseGO:00022501550.016
rna catabolic processGO:0006401290.016
cellular chemical homeostasisGO:00550822150.016
regulation of lymphocyte proliferationGO:00506701170.016
regulation of intracellular transportGO:00323861590.016
gene silencingGO:0016458380.016
dna recombinationGO:0006310920.016
blood vessel morphogenesisGO:00485142850.016
lipid localizationGO:00108761260.016
multicellular organism growthGO:00352641610.016
interleukin 8 productionGO:003263740.016
intrinsic apoptotic signaling pathwayGO:00971931320.016
regulation of protein kinase activityGO:00458592320.015
positive regulation of peptidase activityGO:0010952490.015
respiratory system developmentGO:00605411900.015
peptide transportGO:00158331330.015
positive regulation of protein transportGO:0051222930.015
cytokine biosynthetic processGO:0042089680.015
response to dsrnaGO:0043331300.015
cation transmembrane transportGO:00986552660.015
nuclear transportGO:00511691390.015
immunoglobulin mediated immune responseGO:0016064690.015
neuron deathGO:00709971540.015
negative regulation of cellular protein metabolic processGO:00322692470.015
respiratory tube developmentGO:00303231670.015
necrotic cell deathGO:0070265300.014
cellular homeostasisGO:00197252400.014
cellular component assembly involved in morphogenesisGO:00109271390.014
positive regulation of protein phosphorylationGO:00019342420.014
glycoprotein metabolic processGO:00091001160.014
regulation of type i interferon productionGO:0032479220.014
positive regulation of cell developmentGO:00107202370.014
protein alkylationGO:0008213810.014
negative regulation of cell cycleGO:00457861230.014
positive regulation of nucleoside metabolic processGO:0045979910.014
positive regulation of cellular component biogenesisGO:0044089940.014
regulation of lymphocyte mediated immunityGO:0002706840.014
cytokine metabolic processGO:0042107710.014
lung developmentGO:00303241640.014
cd4 positive alpha beta t cell activationGO:0035710450.014
regulation of cysteine type endopeptidase activityGO:2000116650.014
positive regulation of t cell mediated cytotoxicityGO:0001916150.014
forebrain developmentGO:00309003020.014
organelle fissionGO:00482851700.014
negative regulation of organelle organizationGO:0010639900.014
cellular metal ion homeostasisGO:00068751510.013
intrinsic apoptotic signaling pathway in response to dna damageGO:0008630570.013
regulation of interleukin 1 alpha productionGO:003265040.013
negative regulation of cellular amino acid metabolic processGO:004576300.013
striated muscle tissue developmentGO:00147062930.013
t helper cell differentiationGO:0042093280.013
ubiquitin dependent protein catabolic processGO:00065111290.013
regulation of lymphocyte differentiationGO:00456191070.013
nucleoside phosphate biosynthetic processGO:1901293790.013
digestive system developmentGO:00551232000.013
angiogenesisGO:00015252010.013
glycosylationGO:0070085620.013
mitochondrion organizationGO:00070051340.013
b cell activationGO:00421131610.013
cell fate commitmentGO:00451652100.013
regulation of body fluid levelsGO:00508781620.013
positive regulation of reactive oxygen species biosynthetic processGO:190342820.013
myosin filament assemblyGO:003103420.013
neuron apoptotic processGO:00514021420.013
regulation of leukocyte mediated cytotoxicityGO:0001910380.013
sensory perceptionGO:00076002450.013
regulation of cell killingGO:0031341400.013
t cell mediated immunityGO:0002456500.013
regulation of alpha beta t cell activationGO:0046634530.013
protein methylationGO:0006479810.013
lymphocyte apoptotic processGO:0070227540.013
amide transportGO:00428861380.013
extracellular structure organizationGO:00430621480.013
regulation of synaptic growth at neuromuscular junctionGO:000858240.013
regulation of actin filament based processGO:0032970990.013
positive regulation of apoptotic signaling pathwayGO:2001235950.013
Mouse
stem cell developmentGO:00488642190.013
Mouse
synaptic transmissionGO:00072683290.013
regulation of vesicle mediated transportGO:00606271390.013
positive regulation of secretionGO:00510471300.013
negative regulation of phosphorylationGO:00423261660.013
inorganic cation transmembrane transportGO:00986622070.013
programmed necrotic cell deathGO:0097300280.013
body fluid secretionGO:0007589530.012
regulation of ion transmembrane transportGO:00347651190.012
developmental maturationGO:00217001930.012
Mouse
ossificationGO:00015032160.012
regulation of neuron differentiationGO:00456642810.012
response to light stimulusGO:00094161350.012
peptidyl lysine modificationGO:0018205770.012
reactive oxygen species biosynthetic processGO:190340980.012
regulation of anatomical structure sizeGO:00900661780.012
regulation of neuron deathGO:19012141340.012
cellular protein complex assemblyGO:00436231160.012
meiotic cell cycleGO:00513211220.012
purine nucleoside monophosphate metabolic processGO:0009126810.012
positive regulation of secretion by cellGO:19035321140.012
actin filament organizationGO:00070151130.012
cd4 positive alpha beta t cell differentiationGO:0043367410.012
dendrite developmentGO:00163581150.012
glucose homeostasisGO:00425931280.012
viral transcriptionGO:001908330.012
divalent inorganic cation transportGO:00725111780.012
positive regulation of cell activationGO:00508671580.012
regulation of protein processingGO:0070613960.012
actin filament polymerizationGO:0030041440.012
regionalizationGO:00030023370.012
stem cell maintenanceGO:00198271300.012
Mouse
protein targetingGO:00066051430.012
regulation of establishment of protein localizationGO:00702011810.012
regulation of bindingGO:00510981110.012
nuclear divisionGO:00002801580.012
regulation of homeostatic processGO:00328441820.012
myeloid leukocyte activationGO:0002274830.011
regulation of cytokine biosynthetic processGO:0042035590.011
intracellular receptor signaling pathwayGO:0030522740.011
rac protein signal transductionGO:0016601130.011
plasma membrane organizationGO:0007009900.011
protein acylationGO:0043543640.011
ribonucleoside monophosphate metabolic processGO:0009161800.011
regulation of cytoplasmic transportGO:19036491120.011
regulation of apoptotic signaling pathwayGO:20012331970.011
Mouse
anion transportGO:00068201770.011
alpha beta t cell activationGO:0046631910.011
protein importGO:00170381010.011
negative regulation of immune effector processGO:0002698550.011
nuclear importGO:0051170950.011
regulation of chromosome organizationGO:0033044830.011
immunoglobulin production involved in immunoglobulin mediated immune responseGO:0002381430.011
action potentialGO:0001508780.011
nucleoside monophosphate metabolic processGO:0009123850.011
regulation of rho protein signal transductionGO:0035023710.011
regulation of protein complex assemblyGO:0043254830.011
negative regulation of intracellular signal transductionGO:19025321670.011
regulation of intracellular protein transportGO:0033157820.011
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:0002822870.011
hair cycleGO:0042633900.011
Mouse
atp metabolic processGO:0046034750.011
connective tissue developmentGO:00614481790.011
spermatid developmentGO:00072861080.011
regulation of t cell differentiationGO:0045580830.011
protein localization to plasma membraneGO:0072659570.011
cell divisionGO:00513011200.011
regulation of cd8 positive alpha beta t cell proliferationGO:200056410.011
peptidyl serine modificationGO:0018209830.011
positive regulation of type i interferon mediated signaling pathwayGO:006034040.011
alpha beta t cell differentiation involved in immune responseGO:0002293300.011
gene silencing by mirnaGO:0035195100.011
positive regulation of protein kinase activityGO:00458601440.011
meiotic cell cycle processGO:1903046770.011
regulation of protein catabolic processGO:00421761080.011
metal ion homeostasisGO:00550651890.011
positive regulation of growthGO:00459271040.011
cell substrate adhesionGO:00315891300.011
striated muscle myosin thick filament assemblyGO:007168810.010
positive regulation of rho gtpase activityGO:0032321410.010
regulation of production of molecular mediator of immune responseGO:0002700650.010
neuromuscular processGO:0050905990.010
interferon gamma productionGO:0032609670.010
negative regulation of defense responseGO:0031348770.010
mrna metabolic processGO:0016071840.010
lateral inhibitionGO:004633110.010
regulation of actin cytoskeleton organizationGO:0032956840.010
regulation of neuron apoptotic processGO:00435231220.010
protein import into nucleusGO:0006606950.010
cellular lipid metabolic processGO:00442553230.010
viral gene expressionGO:001908030.010
regulation of sequence specific dna binding transcription factor activityGO:00510901060.010
cd4 positive alpha beta t cell differentiation involved in immune responseGO:0002294280.010
positive regulation of reactive oxygen species metabolic processGO:2000379110.010
regulation of endocytosisGO:0030100690.010
response to acid chemicalGO:00011011110.010
heart morphogenesisGO:00030071780.010
glycoprotein biosynthetic processGO:0009101890.010
oxidation reduction processGO:00551143420.010
positive regulation of ras gtpase activityGO:0032320650.010
methylationGO:00322591340.010
regulation of peptide transportGO:0090087910.010

Gsdmd disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.026
immune system diseaseDOID:291400.026
organ system cancerDOID:005068600.017
cancerDOID:16200.017
disease of cellular proliferationDOID:1456600.017
musculoskeletal system diseaseDOID:1700.014
connective tissue diseaseDOID:6500.014
disease of metabolismDOID:001466700.013
nervous system diseaseDOID:86300.012
gastrointestinal system cancerDOID:311900.010