IMP: Integrative Multi-species Prediction

Mus musculus

0 known processes

Sacm1l

SAC1 (suppressor of actin mutations 1, homolog)-like (S. cerevisiae)

(Aliases: mKIAA0851,SAC1,Sac1p)

Entrez: 83493
Ensembl: ENSMUSG00000025240
UniProtKB: Q9EP69

Process Predictions
Disease Predictions

Sacm1l biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
proteolysis involved in cellular protein catabolic process	GO:0051603	147	0.250
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.232
purine nucleotide catabolic process	GO:0006195	211	0.199
organophosphate catabolic process	GO:0046434	232	0.184	Mouse
nucleoside phosphate metabolic process	GO:0006753	338	0.159
cellular protein catabolic process	GO:0044257	155	0.150
purine nucleoside metabolic process	GO:0042278	241	0.147
purine ribonucleoside metabolic process	GO:0046128	241	0.139
microtubule based process	GO:0007017	236	0.134
nucleoside triphosphate metabolic process	GO:0009141	230	0.124
purine nucleotide metabolic process	GO:0006163	302	0.112
organelle localization	GO:0051640	179	0.109
cellular macromolecule catabolic process	GO:0044265	206	0.095
cellular homeostasis	GO:0019725	240	0.088
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.083
protein catabolic process	GO:0030163	221	0.081
small gtpase mediated signal transduction	GO:0007264	97	0.080
nucleobase containing small molecule metabolic process	GO:0055086	352	0.078
carbohydrate derivative catabolic process	GO:1901136	231	0.076
guanosine containing compound catabolic process	GO:1901069	144	0.076
regulation of vesicle mediated transport	GO:0060627	139	0.075
purine ribonucleotide catabolic process	GO:0009154	208	0.072
transmembrane transport	GO:0055085	412	0.072
modification dependent macromolecule catabolic process	GO:0043632	133	0.071
nucleoside metabolic process	GO:0009116	246	0.071
glycosyl compound metabolic process	GO:1901657	246	0.069
neuron apoptotic process	GO:0051402	142	0.068
ribose phosphate metabolic process	GO:0019693	291	0.068
lipid transport	GO:0006869	98	0.066
cellular lipid metabolic process	GO:0044255	323	0.065	Mouse Rat
purine ribonucleotide metabolic process	GO:0009150	290	0.063
microtubule cytoskeleton organization	GO:0000226	157	0.062
purine ribonucleoside catabolic process	GO:0046130	205	0.062
guanosine containing compound metabolic process	GO:1901068	144	0.061
macromolecule catabolic process	GO:0009057	281	0.060
nucleoside triphosphate catabolic process	GO:0009143	205	0.060
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.060
rab protein signal transduction	GO:0032482	1	0.058
ribonucleoside metabolic process	GO:0009119	245	0.057
nucleotide metabolic process	GO:0009117	332	0.053
spermatid development	GO:0007286	108	0.053
regulation of cell projection organization	GO:0031344	206	0.053
cytokine production	GO:0001816	319	0.053
regulation of organelle organization	GO:0033043	289	0.051
regulation of cell migration	GO:0030334	219	0.051
nucleoside phosphate catabolic process	GO:1901292	222	0.051
heterocycle catabolic process	GO:0046700	280	0.051
cellular chemical homeostasis	GO:0055082	215	0.051
gtp catabolic process	GO:0006184	143	0.049
positive regulation of exocytosis	GO:0045921	20	0.049
intracellular protein transport	GO:0006886	204	0.048
cellular ion homeostasis	GO:0006873	165	0.047
purine nucleoside catabolic process	GO:0006152	205	0.046
membrane organization	GO:0061024	245	0.046
positive regulation of secretion	GO:0051047	130	0.046
endomembrane system organization	GO:0010256	147	0.046
exocytosis	GO:0006887	121	0.045
modification dependent protein catabolic process	GO:0019941	133	0.045
nucleotide catabolic process	GO:0009166	217	0.045
glycosyl compound catabolic process	GO:1901658	206	0.043
protein modification by small protein conjugation	GO:0032446	187	0.042
ras protein signal transduction	GO:0007265	77	0.041
protein localization to organelle	GO:0033365	185	0.041
cellular transition metal ion homeostasis	GO:0046916	32	0.041
regulation of cell cycle process	GO:0010564	160	0.040
cellular metal ion homeostasis	GO:0006875	151	0.040
positive regulation of cellular catabolic process	GO:0031331	148	0.039
nucleoside catabolic process	GO:0009164	206	0.039
centrosome cycle	GO:0007098	23	0.039
protein modification by small protein conjugation or removal	GO:0070647	207	0.039
ribonucleotide metabolic process	GO:0009259	291	0.039
synaptic transmission	GO:0007268	329	0.038
purine containing compound metabolic process	GO:0072521	311	0.038
regulation of secretion	GO:0051046	274	0.038
ubiquitin dependent protein catabolic process	GO:0006511	129	0.036
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.036
meiotic cell cycle process	GO:1903046	77	0.036
homeostasis of number of cells	GO:0048872	210	0.035
positive regulation of secretion by cell	GO:1903532	114	0.035
nitrogen compound transport	GO:0071705	271	0.035
purine containing compound catabolic process	GO:0072523	213	0.034
positive regulation of cell projection organization	GO:0031346	95	0.034
oxidation reduction process	GO:0055114	342	0.034
lipid biosynthetic process	GO:0008610	179	0.033
golgi to endosome transport	GO:0006895	3	0.033
positive regulation of gtpase activity	GO:0043547	85	0.033
cell division	GO:0051301	120	0.033
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	88	0.032
regulation of protein localization	GO:0032880	231	0.032
regulation of exocytosis	GO:0017157	61	0.032
establishment of organelle localization	GO:0051656	122	0.031
organonitrogen compound catabolic process	GO:1901565	264	0.030
protein targeting	GO:0006605	143	0.030
intracellular cholesterol transport	GO:0032367	3	0.029
dna metabolic process	GO:0006259	303	0.029
phospholipid metabolic process	GO:0006644	87	0.029	Mouse Rat
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	112	0.029
ion transmembrane transport	GO:0034220	361	0.029
mitotic cell cycle process	GO:1903047	159	0.028
negative regulation of phosphorus metabolic process	GO:0010563	184	0.028
wnt signaling pathway	GO:0016055	188	0.028
axonogenesis	GO:0007409	274	0.028
metal ion homeostasis	GO:0055065	189	0.028
regulation of cellular catabolic process	GO:0031329	242	0.027
organelle fission	GO:0048285	170	0.027
response to growth factor	GO:0070848	198	0.027
cellular nitrogen compound catabolic process	GO:0044270	280	0.027
cation transport	GO:0006812	399	0.027
leukocyte mediated immunity	GO:0002443	174	0.026
protein localization to membrane	GO:0072657	108	0.026
small molecule catabolic process	GO:0044282	71	0.026
aromatic compound catabolic process	GO:0019439	286	0.026
ribonucleoside triphosphate catabolic process	GO:0009203	199	0.026
lipid localization	GO:0010876	126	0.025
monocarboxylic acid catabolic process	GO:0072329	27	0.025
amide transport	GO:0042886	138	0.025
regulation of cell cycle	GO:0051726	281	0.025
cell type specific apoptotic process	GO:0097285	268	0.025
protein localization to plasma membrane	GO:0072659	57	0.024
mapk cascade	GO:0000165	281	0.024
organic acid transport	GO:0015849	101	0.024
regulation of cell motility	GO:2000145	236	0.023
regulation of neuron projection development	GO:0010975	169	0.023
rho protein signal transduction	GO:0007266	32	0.023
leukocyte differentiation	GO:0002521	342	0.023
cellular lipid catabolic process	GO:0044242	52	0.023	Mouse
peroxisomal transport	GO:0043574	4	0.023
regulation of t cell activation	GO:0050863	170	0.022
peptide secretion	GO:0002790	114	0.022
centrosome duplication	GO:0051298	16	0.022
regulation of ion transport	GO:0043269	215	0.022
anion transport	GO:0006820	177	0.022
microtubule organizing center organization	GO:0031023	28	0.022
calcium ion dependent exocytosis	GO:0017156	35	0.022
organic cyclic compound catabolic process	GO:1901361	295	0.022
protein localization to vacuole	GO:0072665	4	0.022
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.022
organonitrogen compound biosynthetic process	GO:1901566	192	0.021
regulation of membrane potential	GO:0042391	192	0.021
negative regulation of molecular function	GO:0044092	258	0.021
organophosphate biosynthetic process	GO:0090407	122	0.021
intracellular sterol transport	GO:0032366	3	0.021
golgi vesicle transport	GO:0048193	30	0.021
cell adhesion	GO:0007155	329	0.021
regulation of ion transmembrane transport	GO:0034765	119	0.021
regulation of kinase activity	GO:0043549	249	0.020
spermatid differentiation	GO:0048515	115	0.020
vesicle localization	GO:0051648	86	0.020
protein targeting to peroxisome	GO:0006625	4	0.020
ribonucleotide catabolic process	GO:0009261	208	0.020
regulation of lymphocyte activation	GO:0051249	240	0.020
cytoplasmic transport	GO:0016482	234	0.020
establishment of protein localization to peroxisome	GO:0072663	4	0.019
male gamete generation	GO:0048232	285	0.019
axon target recognition	GO:0007412	4	0.019
cellular response to growth factor stimulus	GO:0071363	197	0.019
actin filament organization	GO:0007015	113	0.019
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090101	61	0.019
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.019
regulation of neuron differentiation	GO:0045664	281	0.019
gtp metabolic process	GO:0046039	144	0.019
regulation of secretion by cell	GO:1903530	249	0.019
axon guidance	GO:0007411	141	0.019
cation homeostasis	GO:0055080	212	0.018
early endosome to late endosome transport	GO:0045022	2	0.018
regulation of cytokine production	GO:0001817	266	0.018
meiotic cell cycle	GO:0051321	122	0.018
iron ion homeostasis	GO:0055072	36	0.018
regulation of synaptic plasticity	GO:0048167	87	0.018
peptide transport	GO:0015833	133	0.018
chemotaxis	GO:0006935	247	0.018
actin cytoskeleton organization	GO:0030036	220	0.018
positive regulation of cytokine production	GO:0001819	174	0.018
negative regulation of phosphorylation	GO:0042326	166	0.018
vesicle organization	GO:0016050	60	0.018
regulation of epithelial cell migration	GO:0010632	35	0.017
cellular amino acid metabolic process	GO:0006520	103	0.017
regulation of cellular component size	GO:0032535	121	0.017
forebrain development	GO:0030900	302	0.017
ribonucleoside monophosphate metabolic process	GO:0009161	80	0.017
intracellular lipid transport	GO:0032365	3	0.017
glycerolipid metabolic process	GO:0046486	122	0.017	Mouse Rat
immune effector process	GO:0002252	321	0.017
phosphatidylinositol metabolic process	GO:0046488	45	0.017	Mouse Rat
neuron death	GO:0070997	154	0.016
regulation of transmembrane transport	GO:0034762	128	0.016
cell activation involved in immune response	GO:0002263	126	0.016
transition metal ion homeostasis	GO:0055076	54	0.016
cellular response to transforming growth factor beta stimulus	GO:0071560	88	0.016
posttranscriptional regulation of gene expression	GO:0010608	155	0.016
b cell activation	GO:0042113	161	0.016
alcohol metabolic process	GO:0006066	116	0.016
negative regulation of synapse assembly	GO:0051964	3	0.016
establishment of vesicle localization	GO:0051650	81	0.016
negative regulation of cellular response to growth factor stimulus	GO:0090288	46	0.015
organic hydroxy compound metabolic process	GO:1901615	203	0.015
mitotic cytokinesis	GO:0000281	4	0.015
activation of immune response	GO:0002253	138	0.015
lipid modification	GO:0030258	65	0.015	Rat
regulation of nucleotide catabolic process	GO:0030811	122	0.015
protein localization to peroxisome	GO:0072662	4	0.015
sterol transport	GO:0015918	38	0.015
positive regulation of purine nucleotide catabolic process	GO:0033123	88	0.015
stem cell differentiation	GO:0048863	268	0.015
negative regulation of phosphate metabolic process	GO:0045936	184	0.015
leukocyte proliferation	GO:0070661	172	0.015
small molecule biosynthetic process	GO:0044283	132	0.015
regulation of transforming growth factor beta receptor signaling pathway	GO:0017015	43	0.015
regulation of proteolysis	GO:0030162	164	0.015
lipid catabolic process	GO:0016042	69	0.014	Mouse
regulation of neuronal synaptic plasticity	GO:0048168	30	0.014
phospholipid biosynthetic process	GO:0008654	36	0.014
gland development	GO:0048732	330	0.014
apoptotic signaling pathway	GO:0097190	306	0.014
maintenance of location	GO:0051235	89	0.014
digestive tract morphogenesis	GO:0048546	147	0.014
positive regulation of purine nucleotide metabolic process	GO:1900544	114	0.014
glycerophospholipid metabolic process	GO:0006650	71	0.014	Mouse Rat
carbohydrate metabolic process	GO:0005975	230	0.014
insulin secretion	GO:0030073	89	0.014
synaptic vesicle recycling	GO:0036465	19	0.014
single organism cell adhesion	GO:0098602	156	0.014
regulation of synaptic growth at neuromuscular junction	GO:0008582	4	0.013
divalent inorganic cation homeostasis	GO:0072507	138	0.013
regulation of hormone levels	GO:0010817	211	0.013
establishment of protein localization to vacuole	GO:0072666	4	0.013
establishment of synaptic vesicle localization	GO:0097480	57	0.013
hormone secretion	GO:0046879	128	0.013
gastrulation	GO:0007369	116	0.013
ubiquitin dependent protein catabolic process via the multivesicular body sorting pathway	GO:0043162	3	0.013
blood vessel morphogenesis	GO:0048514	285	0.013
fertilization	GO:0009566	127	0.013
positive regulation of cell motility	GO:2000147	116	0.013
synaptic vesicle endocytosis	GO:0048488	19	0.013
regulation of lymphocyte differentiation	GO:0045619	107	0.013
cellular iron ion homeostasis	GO:0006879	16	0.013
regulation of mapk cascade	GO:0043408	248	0.013
germ cell development	GO:0007281	185	0.013
stem cell development	GO:0048864	219	0.013
single fertilization	GO:0007338	82	0.013
regulation of lymphocyte proliferation	GO:0050670	117	0.013
regulation of wnt signaling pathway	GO:0030111	123	0.013
spermatogenesis	GO:0007283	284	0.013
cellular amine metabolic process	GO:0044106	44	0.013
response to endoplasmic reticulum stress	GO:0034976	53	0.013
cellular protein complex assembly	GO:0043623	116	0.012
purine ribonucleoside monophosphate metabolic process	GO:0009167	80	0.012
regulation of membrane lipid distribution	GO:0097035	16	0.012
lymphocyte proliferation	GO:0046651	164	0.012
regulation of nucleotide metabolic process	GO:0006140	169	0.012
exosomal secretion	GO:1990182	1	0.012
regulation of cell activation	GO:0050865	289	0.012
nucleoside monophosphate metabolic process	GO:0009123	85	0.012
regulation of endocytosis	GO:0030100	69	0.012
regulation of leukocyte proliferation	GO:0070663	121	0.012
regulation of reactive oxygen species metabolic process	GO:2000377	40	0.012
regulation of lipid metabolic process	GO:0019216	118	0.012
regulation of establishment of protein localization	GO:0070201	181	0.012
endocytosis	GO:0006897	168	0.012
regulation of leukocyte differentiation	GO:1902105	159	0.012
establishment of protein localization to organelle	GO:0072594	118	0.012
organelle assembly	GO:0070925	177	0.012
neuron neuron synaptic transmission	GO:0007270	69	0.012
proteasomal protein catabolic process	GO:0010498	98	0.012
negative regulation of protein metabolic process	GO:0051248	282	0.012
positive regulation of protein phosphorylation	GO:0001934	242	0.012
fatty acid metabolic process	GO:0006631	121	0.011
immunoglobulin transcytosis in epithelial cells	GO:0002414	2	0.011
positive regulation of protein modification process	GO:0031401	299	0.011
protein transmembrane transport	GO:0071806	8	0.011
regulation of response to wounding	GO:1903034	189	0.011
cellular divalent inorganic cation homeostasis	GO:0072503	127	0.011
organic acid catabolic process	GO:0016054	51	0.011
regulation of t cell proliferation	GO:0042129	92	0.011
carbohydrate homeostasis	GO:0033500	128	0.011
purine nucleoside monophosphate metabolic process	GO:0009126	81	0.011
sensory organ morphogenesis	GO:0090596	242	0.011
regulation of purine nucleotide catabolic process	GO:0033121	122	0.011
cholesterol transport	GO:0030301	38	0.011
leukocyte activation involved in immune response	GO:0002366	126	0.011
positive regulation of long term neuronal synaptic plasticity	GO:0048170	3	0.011
myeloid cell differentiation	GO:0030099	233	0.011
monocarboxylic acid metabolic process	GO:0032787	191	0.011
spindle organization	GO:0007051	28	0.010
positive regulation of leukocyte differentiation	GO:1902107	86	0.010
protein ubiquitination	GO:0016567	171	0.010
nuclear division	GO:0000280	158	0.010
regulation of protein catabolic process	GO:0042176	108	0.010
regulation of ras gtpase activity	GO:0032318	88	0.010
multi organism behavior	GO:0051705	62	0.010
regulation of cellular response to growth factor stimulus	GO:0090287	82	0.010
glucose homeostasis	GO:0042593	128	0.010
positive regulation of cell migration	GO:0030335	109	0.010
regulated secretory pathway	GO:0045055	32	0.010
amine metabolic process	GO:0009308	45	0.010
positive regulation of rab gtpase activity	GO:0032851	7	0.010
negative regulation of immune system process	GO:0002683	209	0.010
protein import into peroxisome matrix	GO:0016558	3	0.010
epithelial cell development	GO:0002064	159	0.010
positive regulation of gtp catabolic process	GO:0033126	85	0.010

Sacm1l disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
inherited metabolic disorder	DOID:655	0.038
disease of metabolism	DOID:0014667	0.038
disease of anatomical entity	DOID:7	0.023
nervous system disease	DOID:863	0.023
sensory system disease	DOID:0050155	0.015
eye disease	DOID:5614	0.015
eye and adnexa disease	DOID:1492	0.015
retinal degeneration	DOID:8466	0.013
retinal disease	DOID:5679	0.013

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