IMP: Integrative Multi-species Prediction

Mus musculus

56 known processes

Lgals1

lectin, galactose binding, soluble 1

(Aliases: Galbp,L14,L-14.5,galectin-1,Gal-1,AA410090,Lect14)

Entrez: 16852
Ensembl: ENSMUSG00000068220
UniProtKB: P16045

Process Predictions
Disease Predictions

Lgals1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
membrane raft assembly	GO:0001765	3	0.582
integrin biosynthetic process	GO:0045112	1	0.497
cation homeostasis	GO:0055080	212	0.497
regulation of integrin biosynthetic process	GO:0045113	1	0.464
regulation of neuronal synaptic plasticity	GO:0048168	30	0.387
positive regulation of myeloid cell apoptotic process	GO:0033034	4	0.372
cation transport	GO:0006812	399	0.304
membrane organization	GO:0061024	245	0.295
regulation of neutrophil apoptotic process	GO:0033029	1	0.285
positive regulation of neutrophil apoptotic process	GO:0033031	1	0.248
metal ion homeostasis	GO:0055065	189	0.243
cellular response to acid chemical	GO:0071229	68	0.201
cellular metal ion homeostasis	GO:0006875	151	0.200
engulfment of apoptotic cell	GO:0043652	3	0.189
positive regulation of peptide secretion	GO:0002793	33	0.178
protein maturation	GO:0051604	176	0.172
cellular homeostasis	GO:0019725	240	0.168
calcium ion homeostasis	GO:0055074	127	0.161
fibrinolysis	GO:0042730	3	0.159
regulation of body fluid levels	GO:0050878	162	0.159
regulation of vesicle mediated transport	GO:0060627	139	0.153	Mouse
organic acid transport	GO:0015849	101	0.148
negative regulation of cellular protein metabolic process	GO:0032269	247	0.140
synaptic transmission	GO:0007268	329	0.138
regulation of synaptic plasticity	GO:0048167	87	0.118
peptide secretion	GO:0002790	114	0.111
cellular chemical homeostasis	GO:0055082	215	0.105
myosin filament organization	GO:0031033	3	0.105
peptide transport	GO:0015833	133	0.102
coagulation	GO:0050817	78	0.099
regulation of binding	GO:0051098	111	0.095
regulation of secretion	GO:0051046	274	0.095
phagocytosis	GO:0006909	66	0.094
multi multicellular organism process	GO:0044706	109	0.091
striated muscle tissue development	GO:0014706	293	0.090	Zebrafish
protein processing	GO:0016485	163	0.088
oxidation reduction process	GO:0055114	342	0.087
muscle tissue development	GO:0060537	308	0.086	Zebrafish
long chain fatty acid transport	GO:0015909	15	0.085
response to acid chemical	GO:0001101	111	0.084
blood coagulation	GO:0007596	76	0.084
muscle contraction	GO:0006936	101	0.080
regulation of hydrolase activity	GO:0051336	246	0.077
divalent metal ion transport	GO:0070838	172	0.076
anion transport	GO:0006820	177	0.076
positive regulation of secretion	GO:0051047	130	0.075
regulation of peptide transport	GO:0090087	91	0.073
muscle system process	GO:0003012	141	0.071
glycosyl compound metabolic process	GO:1901657	246	0.069
cellular ion homeostasis	GO:0006873	165	0.069
actin cytoskeleton organization	GO:0030036	220	0.069
negative regulation of phagocytosis	GO:0050765	4	0.068
negative regulation of peptidase activity	GO:0010466	46	0.067
cellular calcium ion homeostasis	GO:0006874	119	0.066
hemostasis	GO:0007599	78	0.066
ion transmembrane transport	GO:0034220	361	0.065
neutrophil apoptotic process	GO:0001781	3	0.063
negative regulation of protein metabolic process	GO:0051248	282	0.062
lipid transport	GO:0006869	98	0.062
nitrogen compound transport	GO:0071705	271	0.061
endocytosis	GO:0006897	168	0.060	Mouse
cellular divalent inorganic cation homeostasis	GO:0072503	127	0.059
carboxylic acid transport	GO:0046942	100	0.059
regulation of peptidase activity	GO:0052547	96	0.059
organic anion transport	GO:0015711	137	0.055
plasma membrane organization	GO:0007009	90	0.054
regulation of peptide secretion	GO:0002791	77	0.053
nucleoside triphosphate metabolic process	GO:0009141	230	0.053
inflammatory cell apoptotic process	GO:0006925	11	0.052
transmembrane transport	GO:0055085	412	0.051
cellular response to antibiotic	GO:0071236	4	0.050
negative regulation of protein processing	GO:0010955	79	0.050
regulation of homeostatic process	GO:0032844	182	0.049
endomembrane system organization	GO:0010256	147	0.049
extracellular matrix organization	GO:0030198	147	0.048	Mouse
cellular component assembly involved in morphogenesis	GO:0010927	139	0.047
t cell mediated immunity	GO:0002456	50	0.047
positive regulation of heart rate by epinephrine norepinephrine	GO:0001996	4	0.046
regulation of integrin mediated signaling pathway	GO:2001044	8	0.045
divalent inorganic cation homeostasis	GO:0072507	138	0.045
t cell activation	GO:0042110	289	0.044
apoptotic cell clearance	GO:0043277	17	0.043
regulation of protein maturation	GO:1903317	96	0.042
neutrophil homeostasis	GO:0001780	7	0.042
cell chemotaxis	GO:0060326	81	0.041
positive regulation of cell death	GO:0010942	224	0.041
nucleobase containing small molecule metabolic process	GO:0055086	352	0.041
extracellular structure organization	GO:0043062	148	0.041	Mouse
monocarboxylic acid transport	GO:0015718	44	0.041
skeletal muscle organ development	GO:0060538	163	0.041	Zebrafish
positive regulation of binding	GO:0051099	49	0.040
actomyosin structure organization	GO:0031032	56	0.038
circulatory system process	GO:0003013	197	0.037
regulation of cell cycle process	GO:0010564	160	0.037
leukocyte migration	GO:0050900	124	0.037
amide transport	GO:0042886	138	0.036
chronological cell aging	GO:0001300	1	0.035
divalent inorganic cation transport	GO:0072511	178	0.035
nucleoside triphosphate catabolic process	GO:0009143	205	0.034
positive regulation of mitotic cell cycle phase transition	GO:1901992	17	0.034
regulation of endocytosis	GO:0030100	69	0.034	Mouse
learning or memory	GO:0007611	148	0.034
response to muscle stretch	GO:0035994	1	0.034
regulation of actin filament based process	GO:0032970	99	0.034
cellular response to oxidative stress	GO:0034599	76	0.033
macromolecule catabolic process	GO:0009057	281	0.032
protein heterotetramerization	GO:0051290	4	0.032
cognition	GO:0050890	149	0.032
cellular water homeostasis	GO:0009992	2	0.031
regulation of mitotic cell cycle phase transition	GO:1901990	73	0.031
striated muscle myosin thick filament assembly	GO:0071688	1	0.031
ribose phosphate metabolic process	GO:0019693	291	0.030
early endosome to late endosome transport	GO:0045022	2	0.030
i kappab kinase nf kappab signaling	GO:0007249	85	0.029	Human
positive regulation of programmed cell death	GO:0043068	218	0.029
myosin filament assembly	GO:0031034	2	0.029
positive regulation of cell cycle process	GO:0090068	61	0.029
purine ribonucleotide catabolic process	GO:0009154	208	0.028
immune effector process	GO:0002252	321	0.027
mitotic cell cycle process	GO:1903047	159	0.027
positive regulation of vesicle fusion	GO:0031340	2	0.027
membrane raft organization	GO:0031579	5	0.027
response to vitamin a	GO:0033189	1	0.026
negative regulation of cell motility	GO:2000146	61	0.026
response to osmotic stress	GO:0006970	21	0.025
regulation of cell morphogenesis involved in differentiation	GO:0010769	151	0.025
regulation of cell cycle	GO:0051726	281	0.025
sequestering of calcium ion	GO:0051208	18	0.025
long chain fatty acid import	GO:0044539	2	0.025
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.024
integrin mediated signaling pathway	GO:0007229	27	0.024
regulation of cell motility	GO:2000145	236	0.024
negative regulation of cellular component organization	GO:0051129	194	0.024	Mouse
regulation of muscle system process	GO:0090257	80	0.024
connective tissue development	GO:0061448	179	0.024
lymphocyte proliferation	GO:0046651	164	0.024
regulation of protein kinase activity	GO:0045859	232	0.024
neuromuscular process	GO:0050905	99	0.023
ossification	GO:0001503	216	0.023
detection of muscle stretch	GO:0035995	1	0.023
cell type specific apoptotic process	GO:0097285	268	0.023
purine nucleotide metabolic process	GO:0006163	302	0.023
muscle fiber development	GO:0048747	76	0.022	Zebrafish
membrane invagination	GO:0010324	17	0.022
alpha beta t cell differentiation	GO:0046632	69	0.022
organic hydroxy compound transport	GO:0015850	93	0.022
sequestering of metal ion	GO:0051238	19	0.022
regulation of protein processing	GO:0070613	96	0.022
development of primary sexual characteristics	GO:0045137	143	0.022
negative regulation of endocytosis	GO:0045806	12	0.022	Mouse
regulation of transferase activity	GO:0051338	263	0.021
apoptotic signaling pathway	GO:0097190	306	0.021
regulation of cell projection organization	GO:0031344	206	0.021
striated muscle cell development	GO:0055002	125	0.021	Zebrafish
small gtpase mediated signal transduction	GO:0007264	97	0.021
leukocyte chemotaxis	GO:0030595	69	0.021
regulation of hemostasis	GO:1900046	28	0.020
negative regulation of protein maturation	GO:1903318	79	0.020
l ascorbic acid metabolic process	GO:0019852	4	0.020
neurotransmitter transport	GO:0006836	76	0.020
g1 s transition of mitotic cell cycle	GO:0000082	57	0.020
ribonucleoside triphosphate catabolic process	GO:0009203	199	0.020
positive regulation of apoptotic process	GO:0043065	217	0.020
regulation of heart rate by chemical signal	GO:0003062	4	0.020
regulation of ion transport	GO:0043269	215	0.020
regulation of cell shape	GO:0008360	39	0.020
lymphocyte differentiation	GO:0030098	242	0.020
regulation of gtp catabolic process	GO:0033124	113	0.020
cardiac muscle tissue development	GO:0048738	130	0.020
negative regulation of proteolysis	GO:0045861	74	0.020
negative regulation of blood coagulation	GO:0030195	11	0.019
negative regulation of cell migration	GO:0030336	59	0.019
regulation of system process	GO:0044057	200	0.019
positive regulation of cell cycle phase transition	GO:1901989	17	0.019
multi organism behavior	GO:0051705	62	0.019
acetylcholine transport	GO:0015870	2	0.019
regulation of mitotic cell cycle	GO:0007346	126	0.019
regulation of endopeptidase activity	GO:0052548	89	0.019
response to inorganic substance	GO:0010035	96	0.019
arachidonic acid secretion	GO:0050482	8	0.018
heterocycle catabolic process	GO:0046700	280	0.018
ribonucleotide metabolic process	GO:0009259	291	0.018
circadian sleep wake cycle rem sleep	GO:0042747	1	0.018
generation of precursor metabolites and energy	GO:0006091	103	0.018
positive regulation of mitochondrial calcium ion concentration	GO:0051561	3	0.018
regulation of intracellular transport	GO:0032386	159	0.018
negative regulation of hydrolase activity	GO:0051346	71	0.018
calcium ion transport	GO:0006816	159	0.018
myeloid cell differentiation	GO:0030099	233	0.017
regulation of phosphatidylcholine biosynthetic process	GO:2001245	2	0.017
negative regulation of molecular function	GO:0044092	258	0.017
cholesterol transport	GO:0030301	38	0.017
response to extracellular stimulus	GO:0009991	127	0.017
forebrain development	GO:0030900	302	0.017
collagen fibril organization	GO:0030199	32	0.017
ribonucleoside catabolic process	GO:0042454	206	0.017
nucleoside metabolic process	GO:0009116	246	0.017
negative regulation of protein phosphorylation	GO:0001933	126	0.016
ribonucleotide catabolic process	GO:0009261	208	0.016
cellular response to abiotic stimulus	GO:0071214	56	0.016
regulation of transmembrane transport	GO:0034762	128	0.016
microtubule based process	GO:0007017	236	0.016
ribonucleoside metabolic process	GO:0009119	245	0.016
regulation of nucleoside metabolic process	GO:0009118	130	0.016
purine nucleoside metabolic process	GO:0042278	241	0.016
regulation of proteolysis	GO:0030162	164	0.016
regulation of purine nucleotide metabolic process	GO:1900542	169	0.016
wound healing	GO:0042060	157	0.016	Zebrafish
regulation of cell migration	GO:0030334	219	0.016
cellular ketone metabolic process	GO:0042180	84	0.016
positive regulation of mitotic cell cycle	GO:0045931	41	0.016
chemotaxis	GO:0006935	247	0.016
protein oligomerization	GO:0051259	67	0.016
glycoprotein metabolic process	GO:0009100	116	0.016
water homeostasis	GO:0030104	27	0.015
purine nucleoside catabolic process	GO:0006152	205	0.015
intrinsic apoptotic signaling pathway in response to dna damage	GO:0008630	57	0.015
chloride transmembrane transport	GO:1902476	24	0.015
regulation of neurotransmitter levels	GO:0001505	87	0.015
cytoplasmic transport	GO:0016482	234	0.015
response to oxidative stress	GO:0006979	123	0.015
regulation of cellular component size	GO:0032535	121	0.015
response to nutrient levels	GO:0031667	109	0.015
neural precursor cell proliferation	GO:0061351	121	0.015
skeletal system development	GO:0001501	356	0.015	Mouse
bone development	GO:0060348	120	0.015
cytokinetic process	GO:0032506	2	0.015
cardiac muscle contraction	GO:0060048	32	0.015
regulation of ion transmembrane transport	GO:0034765	119	0.015
sensory organ morphogenesis	GO:0090596	242	0.015
single organismal cell cell adhesion	GO:0016337	131	0.015
regulation of apoptotic signaling pathway	GO:2001233	197	0.014
negative regulation of neuron apoptotic process	GO:0043524	92	0.014
nucleoside phosphate catabolic process	GO:1901292	222	0.014
protein localization to plasma membrane	GO:0072659	57	0.014
regulation of nucleotide metabolic process	GO:0006140	169	0.014
nucleoside phosphate metabolic process	GO:0006753	338	0.014
negative regulation of protein modification process	GO:0031400	163	0.014
maintenance of epithelial cell apical basal polarity	GO:0045199	2	0.014
prostate gland development	GO:0030850	48	0.014
sensory perception	GO:0007600	245	0.013
protein localization to membrane	GO:0072657	108	0.013
positive regulation of nucleotide metabolic process	GO:0045981	114	0.013
protein heterooligomerization	GO:0051291	14	0.013
embryonic organ morphogenesis	GO:0048562	276	0.013
response to calcium ion	GO:0051592	20	0.013
cell volume homeostasis	GO:0006884	9	0.013
male gonad development	GO:0008584	88	0.013
wnt signaling pathway	GO:0016055	188	0.013
nucleotide metabolic process	GO:0009117	332	0.013
water soluble vitamin biosynthetic process	GO:0042364	3	0.013
regulation of cell cycle phase transition	GO:1901987	77	0.013
organelle assembly	GO:0070925	177	0.013
cell growth	GO:0016049	130	0.013
actin cytoskeleton reorganization	GO:0031532	21	0.013
cell matrix adhesion	GO:0007160	68	0.013
gonad development	GO:0008406	141	0.013
myeloid cell homeostasis	GO:0002262	114	0.013
platelet activation	GO:0030168	40	0.012
negative regulation of protein transport	GO:0051224	46	0.012
carboxylic acid biosynthetic process	GO:0046394	86	0.012
actin filament organization	GO:0007015	113	0.012
regulation of cellular catabolic process	GO:0031329	242	0.012
epithelial cell development	GO:0002064	159	0.012
purine ribonucleotide metabolic process	GO:0009150	290	0.012
regulation of cell cycle g1 s phase transition	GO:1902806	35	0.012
fatty acid transport	GO:0015908	28	0.012
regulation of lamellipodium morphogenesis	GO:2000392	1	0.012
release of sequestered calcium ion into cytosol	GO:0051209	42	0.012
negative regulation of neuron death	GO:1901215	98	0.012
cellular response to dna damage stimulus	GO:0006974	207	0.012
organic cyclic compound catabolic process	GO:1901361	295	0.012
purine ribonucleoside catabolic process	GO:0046130	205	0.012
regulation of coagulation	GO:0050818	31	0.012
carbohydrate derivative catabolic process	GO:1901136	231	0.012
small molecule biosynthetic process	GO:0044283	132	0.012
myoblast differentiation	GO:0045445	52	0.012
monocarboxylic acid metabolic process	GO:0032787	191	0.012
respiratory tube development	GO:0030323	167	0.012
t cell proliferation	GO:0042098	120	0.011
ribonucleoside monophosphate metabolic process	GO:0009161	80	0.011
peptide hormone secretion	GO:0030072	109	0.011
ras protein signal transduction	GO:0007265	77	0.011
dna metabolic process	GO:0006259	303	0.011
cellular nitrogen compound catabolic process	GO:0044270	280	0.011
atp metabolic process	GO:0046034	75	0.011
ketone catabolic process	GO:0042182	3	0.011
fatty acid derivative transport	GO:1901571	14	0.011
regulation of neuron death	GO:1901214	134	0.011
positive regulation of hydrolase activity	GO:0051345	148	0.011
purine ribonucleoside metabolic process	GO:0046128	241	0.011
muscle cell differentiation	GO:0042692	261	0.011
regulation of organelle organization	GO:0033043	289	0.011
intestinal absorption	GO:0050892	13	0.011
protein localization to organelle	GO:0033365	185	0.011
membrane assembly	GO:0071709	12	0.011
regulation of purine nucleotide catabolic process	GO:0033121	122	0.011
regulation of membrane potential	GO:0042391	192	0.011
purine ribonucleoside monophosphate catabolic process	GO:0009169	57	0.011
inner ear morphogenesis	GO:0042472	101	0.011
epithelial cell morphogenesis	GO:0003382	41	0.011
protein catabolic process	GO:0030163	221	0.011
hormone secretion	GO:0046879	128	0.011
skeletal muscle fiber development	GO:0048741	58	0.011	Zebrafish
regulation of protein catabolic process	GO:0042176	108	0.011
lipid localization	GO:0010876	126	0.011
negative regulation of hemostasis	GO:1900047	11	0.011
regulation of hormone levels	GO:0010817	211	0.011
mitotic cytokinesis	GO:0000281	4	0.011
regulation of cell substrate adhesion	GO:0010810	73	0.010
response to metal ion	GO:0010038	47	0.010
negative regulation of endopeptidase activity	GO:0010951	44	0.010
regulation of wnt signaling pathway	GO:0030111	123	0.010
cardiac muscle cell differentiation	GO:0055007	69	0.010
response to organonitrogen compound	GO:0010243	246	0.010
substantia nigra development	GO:0021762	2	0.010
carbohydrate metabolic process	GO:0005975	230	0.010
peripheral nervous system axon regeneration	GO:0014012	2	0.010
activation of cdc42 gtpase activity	GO:0032864	2	0.010
cardiac ventricle development	GO:0003231	83	0.010
platelet aggregation	GO:0070527	20	0.010
regulation of phospholipid biosynthetic process	GO:0071071	3	0.010
positive regulation of muscle cell differentiation	GO:0051149	39	0.010

Lgals1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
bone development disease	DOID:0080006	0.096
connective tissue disease	DOID:65	0.096
musculoskeletal system disease	DOID:17	0.096
disease of anatomical entity	DOID:7	0.096
bone disease	DOID:0080001	0.096
disease of metabolism	DOID:0014667	0.057
osteochondrodysplasia	DOID:2256	0.035
nervous system disease	DOID:863	0.034
immune system disease	DOID:2914	0.023
primary immunodeficiency disease	DOID:612	0.023
sensory system disease	DOID:0050155	0.014
eye disease	DOID:5614	0.014
eye and adnexa disease	DOID:1492	0.014
acquired metabolic disease	DOID:0060158	0.011
brain disease	DOID:936	0.010
epilepsy syndrome	DOID:1826	0.010
central nervous system disease	DOID:331	0.010

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