Mus musculus

148 known processes

Spop

speckle-type POZ protein

(Aliases: TEF2,Pcif1,AI315626)

Spop biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
ion transmembrane transportGO:00342203610.168
transmembrane transportGO:00550854120.165
actin cytoskeleton organizationGO:00300362200.093
multicellular organismal signalingGO:0035637910.084
regulation of cell cycleGO:00517262810.082
intracellular protein transportGO:00068862040.076
inorganic ion transmembrane transportGO:00986602340.075
cation transportGO:00068123990.074
response to organonitrogen compoundGO:00102432460.073
regulation of membrane potentialGO:00423911920.072
negative regulation of protein metabolic processGO:00512482820.066
transmission of nerve impulseGO:0019226760.065
action potentialGO:0001508780.064
protein catabolic processGO:00301632210.063
macromolecule catabolic processGO:00090572810.059
protein modification by small protein conjugation or removalGO:00706472070.059
modification dependent macromolecule catabolic processGO:00436321330.057
regulation of transmembrane transportGO:00347621280.057
protein localization to organelleGO:00333651850.057
cellular amino acid metabolic processGO:00065201030.057
cation transmembrane transportGO:00986552660.056
regulation of cellular ketone metabolic processGO:0010565660.052
positive regulation of ion transportGO:0043270650.050
inorganic cation transmembrane transportGO:00986622070.048
negative regulation of molecular functionGO:00440922580.048
morphogenesis of embryonic epitheliumGO:00163311590.047
neuronal action potentialGO:0019228540.047
regulation of ion transportGO:00432692150.046
carbohydrate metabolic processGO:00059752300.046
nitrogen compound transportGO:00717052710.046
regulation of cellular response to stressGO:00801351590.045
regulation of cell cycle processGO:00105641600.045
myosin filament assemblyGO:003103420.045
protein ubiquitinationGO:00165671710.044
cellular macromolecule catabolic processGO:00442652060.044
proteasomal protein catabolic processGO:0010498980.043
cellular homeostasisGO:00197252400.043
ossificationGO:00015032160.042
ubiquitin dependent protein catabolic processGO:00065111290.041
synaptic transmissionGO:00072683290.041
cellular ketone metabolic processGO:0042180840.041
protein maturationGO:00516041760.040
regulation of ion transmembrane transportGO:00347651190.039
negative regulation of cellular protein metabolic processGO:00322692470.039
posttranscriptional regulation of gene expressionGO:00106081550.039
cytokine productionGO:00018163190.038
meiotic nuclear divisionGO:00071261150.038
striated muscle myosin thick filament assemblyGO:007168810.037
endomembrane system organizationGO:00102561470.037
multicellular organism growthGO:00352641610.037
striated muscle tissue developmentGO:00147062930.036
engulfment of apoptotic cellGO:004365230.036
negative regulation of cell proliferationGO:00082852960.036
monocarboxylic acid metabolic processGO:00327871910.035
cellular component assembly involved in morphogenesisGO:00109271390.035
muscle cell differentiationGO:00426922610.035
monosaccharide metabolic processGO:00059961060.035
nucleotide metabolic processGO:00091173320.035
calcium ion transportGO:00068161590.035
cellular protein catabolic processGO:00442571550.034
dendrite developmentGO:00163581150.034
regulation of translationGO:0006417710.034
cellular lipid metabolic processGO:00442553230.034
peptidyl amino acid modificationGO:00181933360.033
striated muscle cell developmentGO:00550021250.033
positive regulation of fatty acid biosynthetic processGO:004572330.033
neuron projection extensionGO:1990138640.033
cellular response to growth factor stimulusGO:00713631970.033
regulation of homeostatic processGO:00328441820.033
negative regulation of phosphate metabolic processGO:00459361840.033
regulation of defense responseGO:00313472330.032
nuclear transportGO:00511691390.032
divalent metal ion transportGO:00708381720.032
regulation of metal ion transportGO:00109591060.032
learning or memoryGO:00076111480.031
protein processingGO:00164851630.031
connective tissue developmentGO:00614481790.031
response to oxidative stressGO:00069791230.030
lipid biosynthetic processGO:00086101790.030
myeloid cell differentiationGO:00300992330.030
plasma membrane organizationGO:0007009900.030
regulation of synaptic growth at neuromuscular junctionGO:000858240.029
muscle tissue developmentGO:00605373080.029
spermatogenesisGO:00072832840.029
response to peptideGO:19016521360.029
intrinsic apoptotic signaling pathwayGO:00971931320.029
amine metabolic processGO:0009308450.028
organelle localizationGO:00516401790.028
chromatin modificationGO:00165681870.028
anion transportGO:00068201770.028
protein localization to plasma membraneGO:0072659570.027
positive regulation of proteolysisGO:0045862850.027
regulation of cytokine productionGO:00018172660.027
leukocyte differentiationGO:00025213420.027
potassium ion transportGO:0006813520.027
cellular chemical homeostasisGO:00550822150.027
purine ribonucleoside catabolic processGO:00461302050.027
regulation of system processGO:00440572000.027
microtubule based processGO:00070172360.027
adult locomotory behaviorGO:0008344910.027
organic acid biosynthetic processGO:0016053860.026
organic hydroxy compound metabolic processGO:19016152030.026
nucleocytoplasmic transportGO:00069131390.026
proteolysis involved in cellular protein catabolic processGO:00516031470.026
homeostasis of number of cellsGO:00488722100.026
regulation of ion transmembrane transporter activityGO:0032412540.026
fat cell differentiationGO:00454441600.026
carboxylic acid biosynthetic processGO:0046394860.026
endocytosisGO:00068971680.026
protein localization to membraneGO:00726571080.026
mitochondrion distributionGO:004831140.026
memoryGO:0007613580.025
glycosyl compound catabolic processGO:19016582060.025
regulation of proteolysisGO:00301621640.025
regulation of cellular amino acid metabolic processGO:000652150.025
regulation of muscle tissue developmentGO:1901861970.025
myosin filament organizationGO:003103330.025
canonical wnt signaling pathwayGO:00600701300.025
dephosphorylationGO:00163111290.025
chemotaxisGO:00069352470.025
gland developmentGO:00487323300.024
regulation of reactive oxygen species biosynthetic processGO:190342620.024
positive regulation of reactive oxygen species metabolic processGO:2000379110.024
stem cell differentiationGO:00488632680.024
cytoplasmic transportGO:00164822340.024
apoptotic signaling pathwayGO:00971903060.024
regulation of organelle organizationGO:00330432890.024
cellular response to dna damage stimulusGO:00069742070.024
telencephalon developmentGO:00215371860.024
alcohol metabolic processGO:00060661160.024
positive regulation of reactive oxygen species biosynthetic processGO:190342820.024
divalent inorganic cation transportGO:00725111780.023
nuclear divisionGO:00002801580.023
muscle cell developmentGO:00550011330.023
regulation of mapk cascadeGO:00434082480.023
ribonucleotide metabolic processGO:00092592910.023
heterocycle catabolic processGO:00467002800.023
protein targetingGO:00066051430.023
carbohydrate homeostasisGO:00335001280.023
lipid localizationGO:00108761260.023
glucose homeostasisGO:00425931280.023
regulation of cell morphogenesis involved in differentiationGO:00107691510.023
g protein coupled receptor signaling pathwayGO:00071862430.022
negative regulation of protein modification processGO:00314001630.022
response to inorganic substanceGO:0010035960.022
forebrain developmentGO:00309003020.022
negative regulation of phosphorus metabolic processGO:00105631840.022
cellular nitrogen compound catabolic processGO:00442702800.022
regulation of cellular amine metabolic processGO:0033238200.022
monocarboxylic acid biosynthetic processGO:0072330610.022
organelle fissionGO:00482851700.022
cellular amine metabolic processGO:0044106440.022
negative regulation of intracellular signal transductionGO:19025321670.022
nucleoside metabolic processGO:00091162460.021
organic cyclic compound catabolic processGO:19013612950.021
regulation of neuron differentiationGO:00456642810.021
membrane organizationGO:00610242450.021
ribonucleoside catabolic processGO:00424542060.021
organonitrogen compound biosynthetic processGO:19015661920.021
purine nucleotide metabolic processGO:00061633020.021
ribose phosphate metabolic processGO:00196932910.021
calcium ion homeostasisGO:00550741270.021
purine ribonucleoside triphosphate catabolic processGO:00092071990.021
defecationGO:003042110.021
lateral inhibitionGO:004633110.021
regulation of isoprenoid metabolic processGO:001974710.021
muscle contractionGO:00069361010.021
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781940.020
cellular ion homeostasisGO:00068731650.020
response to light stimulusGO:00094161350.020
regulation of lymphocyte activationGO:00512492400.020
cation homeostasisGO:00550802120.020
wound healingGO:00420601570.020
purine nucleoside catabolic processGO:00061522050.020
cognitionGO:00508901490.020
cellular response to organonitrogen compoundGO:00714171450.020
activation of immune responseGO:00022531380.020
skeletal system morphogenesisGO:00487052030.020
regulation of striated muscle cell differentiationGO:0051153810.020
regulation of secretionGO:00510462740.020
translationGO:0006412930.020
nucleoside phosphate metabolic processGO:00067533380.020
chondrocyte differentiationGO:0002062720.020
regulation of response to woundingGO:19030341890.019
regulation of hormone levelsGO:00108172110.019
maintenance of locationGO:0051235890.019
regulation of transferase activityGO:00513382630.019
mrna processingGO:0006397630.019
cellular response to hormone stimulusGO:00328701500.019
regulation of endoplasmic reticulum stress induced intrinsic apoptotic signaling pathwayGO:1902235110.019
cellularizationGO:000734910.019
compound eye developmentGO:004874910.019
nucleobase containing small molecule metabolic processGO:00550863520.019
cellular alcohol biosynthetic processGO:004410830.019
positive regulation of programmed cell deathGO:00430682180.019
regulation of hydrolase activityGO:00513362460.019
myeloid cell homeostasisGO:00022621140.019
germ cell developmentGO:00072811850.019
cellular calcium ion homeostasisGO:00068741190.019
mrna metabolic processGO:0016071840.019
positive regulation of intracellular transportGO:0032388700.019
blood vessel morphogenesisGO:00485142850.019
regulation of intracellular transportGO:00323861590.019
purine containing compound metabolic processGO:00725213110.019
glycerolipid metabolic processGO:00464861220.018
skeletal muscle organ developmentGO:00605381630.018
developmental cell growthGO:0048588840.018
regulation of secretion by cellGO:19035302490.018
reactive oxygen species biosynthetic processGO:190340980.018
innate immune responseGO:00450871570.018
regulation of cell sizeGO:0008361720.018
protein ubiquitination involved in ubiquitin dependent protein catabolic processGO:0042787250.018
intracellular mrna localizationGO:000829840.018
regulation of protein transportGO:00512231630.018
circadian rhythmGO:00076231140.018
sodium ion transportGO:0006814730.018
positive regulation of cytosolic calcium ion concentration involved in phospholipase c activating g protein coupled signaling pathwayGO:005148240.018
regulation of cell projection organizationGO:00313442060.018
positive regulation of cellular catabolic processGO:00313311480.018
negative regulation of kinase activityGO:0033673810.018
rna processingGO:00063961050.018
positive regulation of potassium ion transportGO:004326830.018
immune effector processGO:00022523210.018
regulation of anatomical structure sizeGO:00900661780.018
negative regulation of phosphorylationGO:00423261660.018
positive regulation of cellular amine metabolic processGO:003324050.018
chromatin organizationGO:00063252060.018
organophosphate catabolic processGO:00464342320.018
sensory organ morphogenesisGO:00905962420.018
lipid homeostasisGO:0055088630.018
carbohydrate derivative biosynthetic processGO:19011371830.018
developmental growth involved in morphogenesisGO:00605601380.017
embryonic organ morphogenesisGO:00485622760.017
cell fate commitmentGO:00451652100.017
regulation of cell motilityGO:20001452360.017
purine nucleoside metabolic processGO:00422782410.017
calcium ion transmembrane transportGO:0070588850.017
cellular metal ion homeostasisGO:00068751510.017
skeletal system developmentGO:00015013560.017
positive regulation of muscle cell differentiationGO:0051149390.017
regulation of endopeptidase activityGO:0052548890.017
organic anion transportGO:00157111370.017
axon ensheathmentGO:0008366760.017
cellular response to cadmium ionGO:007127630.017
glycerophospholipid metabolic processGO:0006650710.017
cell growthGO:00160491300.017
regulation of transporter activityGO:0032409570.017
regulation of feeding behaviorGO:006025930.017
organelle assemblyGO:00709251770.017
sequestering of calcium ionGO:0051208180.017
substantia nigra developmentGO:002176220.017
regulation of nuclear cell cycle dna replicationGO:003326220.017
organonitrogen compound catabolic processGO:19015652640.017
regulation of establishment of protein localizationGO:00702011810.017
cell adhesionGO:00071553290.017
mapk cascadeGO:00001652810.016
blood circulationGO:00080151950.016
response to lipopolysaccharideGO:00324961280.016
axonogenesisGO:00074092740.016
regulation of cell migrationGO:00303342190.016
cellular carbohydrate metabolic processGO:00442621190.016
regulation of protein kinase activityGO:00458592320.016
myeloid leukocyte differentiationGO:00025731190.016
autophagyGO:0006914450.016
anatomical structure homeostasisGO:00602491450.016
response to endoplasmic reticulum stressGO:0034976530.016
cell type specific apoptotic processGO:00972852680.016
macromolecule glycosylationGO:0043413550.016
lipid modificationGO:0030258650.016
microtubule cytoskeleton organizationGO:00002261570.016
regulation of cellular component biogenesisGO:00440871810.016
sequestering of metal ionGO:0051238190.016
positive regulation of cellular amino acid metabolic processGO:004576430.016
metal ion homeostasisGO:00550651890.016
cytokinetic processGO:003250620.015
small molecule catabolic processGO:0044282710.015
small molecule biosynthetic processGO:00442831320.015
response to radiationGO:00093141650.015
tissue homeostasisGO:00018941150.015
respiratory system developmentGO:00605411900.015
cellular response to inorganic substanceGO:0071241370.015
angiogenesisGO:00015252010.015
regulation of cytoplasmic transportGO:19036491120.015
determination of digestive tract left right asymmetryGO:007190710.015
regulation of protein serine threonine kinase activityGO:00719001570.015
t cell activationGO:00421102890.015
response to uvGO:0009411440.015
protein glycosylationGO:0006486550.015
neuron apoptotic processGO:00514021420.015
positive regulation of endocytosisGO:0045807420.015
digestive tract developmentGO:00485651900.015
locomotory behaviorGO:00076261950.015
dna metabolic processGO:00062593030.015
oocyte anterior posterior axis specificationGO:000731420.015
positive regulation of cell cycleGO:0045787920.015
regulation of protein localizationGO:00328802310.015
negative regulation of transferase activityGO:0051348850.015
regulation of cell adhesionGO:00301551540.015
regulation of reactive oxygen species metabolic processGO:2000377400.015
cellular protein complex assemblyGO:00436231160.015
fatty acid biosynthetic processGO:0006633410.015
cellular response to arsenic containing substanceGO:007124340.015
positive regulation of secretionGO:00510471300.015
glycosyl compound metabolic processGO:19016572460.015
peptidyl serine modificationGO:0018209830.015
negative regulation of protein phosphorylationGO:00019331260.015
protein modification by small protein conjugationGO:00324461870.014
multi multicellular organism processGO:00447061090.014
ribonucleoside metabolic processGO:00091192450.014
regulation of ketone biosynthetic processGO:001056620.014
histone modificationGO:00165701590.014
regulation of cellular catabolic processGO:00313292420.014
response to growth factorGO:00708481980.014
response to molecule of bacterial originGO:00022371430.014
glycosylationGO:0070085620.014
muscle system processGO:00030121410.014
regulation of meiotic cell cycleGO:0051445340.014
positive regulation of protein phosphorylationGO:00019342420.014
male gamete generationGO:00482322850.014
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071692470.014
divalent inorganic cation homeostasisGO:00725071380.014
oocyte axis specificationGO:000730920.014
regulation of intracellular protein transportGO:0033157820.014
positive regulation of hydrolase activityGO:00513451480.014
multicellular organismal homeostasisGO:00488711640.014
purine ribonucleoside metabolic processGO:00461282410.014
regulation of neuron projection developmentGO:00109751690.014
cellular response to lipidGO:00713961450.014
covalent chromatin modificationGO:00165691630.014
positive regulation of macrophage derived foam cell differentiationGO:001074440.014
glycoprotein biosynthetic processGO:0009101890.014
midgut developmentGO:000749440.014
stress activated protein kinase signaling cascadeGO:0031098810.014
regulation of ossificationGO:00302781120.014
ensheathment of neuronsGO:0007272760.014
respiratory tube developmentGO:00303231670.014
response to organic cyclic compoundGO:00140701980.014
synapse organizationGO:00508081250.014
positive regulation of growthGO:00459271040.014
modification dependent protein catabolic processGO:00199411330.014
regulation of fat cell differentiationGO:0045598810.014
mitochondrion organizationGO:00070051340.014
cellular response to light stimulusGO:0071482190.014
cellular response to biotic stimulusGO:0071216920.014
regionalizationGO:00030023370.013
aromatic compound catabolic processGO:00194392860.013
sensory perceptionGO:00076002450.013
nucleoside catabolic processGO:00091642060.013
regulation of myotube differentiationGO:0010830620.013
regulation of canonical wnt signaling pathwayGO:0060828820.013
circulatory system processGO:00030131970.013
regulation of kinase activityGO:00435492490.013
regulation of apoptotic signaling pathwayGO:20012331970.013
regulation of cell activationGO:00508652890.013
muscle fiber developmentGO:0048747760.013
negative regulation of cell cycleGO:00457861230.013
hindbrain developmentGO:00309021280.013
ubiquitin dependent protein catabolic process via the multivesicular body sorting pathwayGO:004316230.013
mitotic cell cycleGO:00002781950.013
fatty acid metabolic processGO:00066311210.013
meiotic cell cycleGO:00513211220.013
negative regulation of cellular amine metabolic processGO:003323910.013
pole plasm assemblyGO:000731520.013
negative regulation of cellular component organizationGO:00511291940.013
myofibril assemblyGO:0030239340.013
oocyte constructionGO:000730820.013
response to extracellular stimulusGO:00099911270.013
small gtpase mediated signal transductionGO:0007264970.013
peptidyl tyrosine modificationGO:00182121450.013
negative regulation of organelle organizationGO:0010639900.013
syncytium formation by plasma membrane fusionGO:0000768420.013
myelinationGO:0042552740.013
reactive nitrogen species metabolic processGO:200105700.013
positive regulation of intracellular protein transportGO:0090316420.013
inflammatory responseGO:00069542440.013
cellular amino acid catabolic processGO:0009063250.013
cellular response to oxidative stressGO:0034599760.012
response to peptide hormoneGO:00434341270.012
actin filament based movementGO:0030048230.012
glucose metabolic processGO:0006006920.012
proteasome mediated ubiquitin dependent protein catabolic processGO:0043161880.012
negative regulation of wnt signaling pathwayGO:0030178730.012
lung developmentGO:00303241640.012
regulation of intrinsic apoptotic signaling pathwayGO:2001242610.012
adaptive immune responseGO:00022501550.012
hexose metabolic processGO:0019318980.012
cell activation involved in immune responseGO:00022631260.012
regulation of jnk cascadeGO:0046328620.012
liver developmentGO:0001889660.012
actomyosin structure organizationGO:0031032560.012
positive regulation of neuron differentiationGO:00456661410.012
nucleotide catabolic processGO:00091662170.012
carboxylic acid transportGO:00469421000.012
protein localization to nucleusGO:00345041210.012
nucleoside phosphate catabolic processGO:19012922220.012
hematopoietic progenitor cell differentiationGO:00022441430.012
myoblast differentiationGO:0045445520.012
pallium developmentGO:00215431200.012
establishment of organelle localizationGO:00516561220.012
regulation of nucleotide catabolic processGO:00308111220.012
regulation of cellular component sizeGO:00325351210.012
lymphocyte proliferationGO:00466511640.012
ras protein signal transductionGO:0007265770.012
leukocyte activation involved in immune responseGO:00023661260.012
positive regulation of cell deathGO:00109422240.012
nucleoside triphosphate catabolic processGO:00091432050.012
regulation of myeloid cell differentiationGO:0045637960.012
myotube differentiationGO:00149021050.012
regulation of cell cycle phase transitionGO:1901987770.012
regulation of muscle contractionGO:0006937490.012
purine nucleotide catabolic processGO:00061952110.012
cellular divalent inorganic cation homeostasisGO:00725031270.012
carbohydrate derivative catabolic processGO:19011362310.012
positive regulation of protein modification processGO:00314012990.012
regulation of inflammatory responseGO:00507271470.012
male genitalia morphogenesisGO:004880840.011
purine ribonucleotide catabolic processGO:00091542080.011
lymphocyte differentiationGO:00300982420.011
dna repairGO:00062811070.011
skeletal myofibril assemblyGO:001486640.011
purine ribonucleotide metabolic processGO:00091502900.011
regulation of ion homeostasisGO:2000021640.011
positive regulation of secretion by cellGO:19035321140.011
t cell anergyGO:000287040.011
blastocyst developmentGO:0001824800.011
bmp signaling pathwayGO:0030509930.011
cell junction organizationGO:0034330770.011
guanosine containing compound catabolic processGO:19010691440.011
purine nucleoside triphosphate catabolic processGO:00091462030.011
oxidation reduction processGO:00551143420.011
negative regulation of membrane potentialGO:004583740.011
neuron projection guidanceGO:00974851410.011
cellular response to peptideGO:1901653920.011
positive regulation of apoptotic processGO:00430652170.011
positive regulation of cell developmentGO:00107202370.011
organic acid transportGO:00158491010.011
lung epithelium developmentGO:0060428370.011
negative regulation of mapk cascadeGO:0043409650.011
regulation of lipid metabolic processGO:00192161180.011
positive regulation of necrotic cell deathGO:001094010.011
cellular response to insulin stimulusGO:0032869780.011
l amino acid transportGO:0015807320.011
regulation of protein maturationGO:1903317960.011
heart morphogenesisGO:00030071780.011
neural tube developmentGO:00219151600.011
negative regulation of immune system processGO:00026832090.011
negative regulation of cell activationGO:00508661110.011
regulation of calcium ion transportGO:0051924690.011
positive regulation of synaptic growth at neuromuscular junctionGO:004588710.011
fertilizationGO:00095661270.011
cellular potassium ion transportGO:0071804430.011
negative regulation of synapse assemblyGO:005196430.011
response to transforming growth factor betaGO:0071559880.011
response to nitric oxideGO:007173140.011
regulation of nucleocytoplasmic transportGO:0046822730.011
purine ribonucleoside triphosphate metabolic processGO:00092052200.011
male meiosisGO:0007140370.011
regulation of mitotic cell cycleGO:00073461260.011
regulation of nucleoside metabolic processGO:00091181300.011
negative regulation of multi organism processGO:0043901680.011
negative regulation of apoptotic signaling pathwayGO:20012341040.011
regulation of autophagyGO:0010506300.011
male sex differentiationGO:00466611090.011
purine containing compound catabolic processGO:00725232130.011
cellular response to molecule of bacterial originGO:0071219830.011
cdp choline pathwayGO:000665720.011
adult behaviorGO:00305341350.011
wnt signaling pathwayGO:00160551880.011
leukocyte migrationGO:00509001240.011
regulation of protein processingGO:0070613960.011
primary neural tube formationGO:0014020950.010
synapse assemblyGO:0007416560.010
stem cell developmentGO:00488642190.010
establishment of synaptic vesicle localizationGO:0097480570.010
nuclear importGO:0051170950.010
negative regulation of nervous system developmentGO:00519611560.010
cytosolic calcium ion homeostasisGO:0051480700.010
cell maturationGO:00484691270.010
formation of primary germ layerGO:0001704770.010
rhythmic processGO:00485111740.010
maternal determination of anterior posterior axis embryoGO:000835820.010
leukocyte proliferationGO:00706611720.010
embryonic epithelial tube formationGO:00018381300.010
myoblast differentiation involved in skeletal muscle regenerationGO:001483530.010
extrinsic apoptotic signaling pathwayGO:00971911260.010
establishment of mitochondrion localizationGO:005165440.010
axon guidanceGO:00074111410.010

Spop disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
physical disorderDOID:008001500.023
congenital nervous system abnormalityDOID:249000.023
nervous system diseaseDOID:86300.022
disease of anatomical entityDOID:700.022
musculoskeletal system diseaseDOID:1700.018
bone diseaseDOID:008000100.012
connective tissue diseaseDOID:6500.012
cancerDOID:16200.011
organ system cancerDOID:005068600.011
disease of cellular proliferationDOID:1456600.011