IMP: Integrative Multi-species Prediction

Mus musculus

51 known processes

Lhx8

LIM homeobox protein 8

(Aliases: L3,Lhx7)

Ensembl: ENSMUSG00000028201
Entrez: 16875
UniProtKB: O35652

Process Predictions
Disease Predictions

Lhx8 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
skeletal system morphogenesis	GO:0048705	203	0.202	Mouse
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.182
regulation of mapk cascade	GO:0043408	248	0.156
bmp signaling pathway	GO:0030509	93	0.140
axonogenesis	GO:0007409	274	0.140	Mouse
amine metabolic process	GO:0009308	45	0.123
morphogenesis of a branching epithelium	GO:0061138	193	0.123	Mouse
cell fate commitment	GO:0045165	210	0.117	Mouse Worm
cell type specific apoptotic process	GO:0097285	268	0.117	Mouse
positive regulation of protein modification process	GO:0031401	299	0.114	Mouse
visceral motor neuron differentiation	GO:0021524	3	0.113	Mouse
regulation of neuron death	GO:1901214	134	0.110	Mouse
glial cell differentiation	GO:0010001	131	0.104
nerve development	GO:0021675	67	0.104	Mouse
neuron apoptotic process	GO:0051402	142	0.101	Mouse
immune effector process	GO:0002252	321	0.097
developmental growth involved in morphogenesis	GO:0060560	138	0.095	Mouse
cellular amino acid metabolic process	GO:0006520	103	0.095
negative regulation of phosphate metabolic process	GO:0045936	184	0.094
cation homeostasis	GO:0055080	212	0.092
stem cell differentiation	GO:0048863	268	0.091	Mouse
stem cell proliferation	GO:0072089	117	0.090
regulation of cellular ketone metabolic process	GO:0010565	66	0.087
telencephalon development	GO:0021537	186	0.085	Mouse
regulation of neuron apoptotic process	GO:0043523	122	0.085	Mouse
cerebral cortex neuron differentiation	GO:0021895	19	0.084	Mouse
mapk cascade	GO:0000165	281	0.078
epithelial cell morphogenesis	GO:0003382	41	0.077
regulation of cellular amine metabolic process	GO:0033238	20	0.077
gliogenesis	GO:0042063	141	0.077
nucleoside metabolic process	GO:0009116	246	0.076
cellular ketone metabolic process	GO:0042180	84	0.074
leukocyte differentiation	GO:0002521	342	0.073
negative regulation of phosphorus metabolic process	GO:0010563	184	0.073
positive regulation of apoptotic process	GO:0043065	217	0.070
camera type eye development	GO:0043010	266	0.069	Mouse
positive regulation of programmed cell death	GO:0043068	218	0.068
protein maturation	GO:0051604	176	0.068
response to molecule of bacterial origin	GO:0002237	143	0.066
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.066
regulation of protein localization	GO:0032880	231	0.065
hindbrain development	GO:0030902	128	0.065	Mouse
forebrain neuron differentiation	GO:0021879	52	0.065
somitogenesis	GO:0001756	69	0.064	Mouse
neural precursor cell proliferation	GO:0061351	121	0.064	Mouse
organ growth	GO:0035265	117	0.064	Mouse
motor neuron migration	GO:0097475	4	0.063	Mouse
endocrine system development	GO:0035270	98	0.063	Mouse
regulation of cellular amino acid metabolic process	GO:0006521	5	0.062
hematopoietic progenitor cell differentiation	GO:0002244	143	0.060
regulation of neural precursor cell proliferation	GO:2000177	70	0.059	Mouse
posttranscriptional regulation of gene expression	GO:0010608	155	0.058
cytokine production	GO:0001816	319	0.058	Mouse
neuron death	GO:0070997	154	0.057	Mouse
muscle tissue development	GO:0060537	308	0.056	Mouse
positive regulation of cell development	GO:0010720	237	0.056
regulation of hydrolase activity	GO:0051336	246	0.056
membrane organization	GO:0061024	245	0.055
cell fate specification	GO:0001708	72	0.055	Mouse Worm
renal system development	GO:0072001	225	0.054	Mouse
negative regulation of cell development	GO:0010721	169	0.054	Mouse
kidney epithelium development	GO:0072073	121	0.054	Mouse
negative regulation of immune system process	GO:0002683	209	0.053
embryonic skeletal system development	GO:0048706	120	0.053	Mouse
transmembrane transport	GO:0055085	412	0.053
muscle system process	GO:0003012	141	0.053
protein processing	GO:0016485	163	0.053
positive regulation of cell death	GO:0010942	224	0.051
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	112	0.051
muscle contraction	GO:0006936	101	0.050
intracellular protein transport	GO:0006886	204	0.050
autonomic nervous system development	GO:0048483	43	0.049
cardiac ventricle morphogenesis	GO:0003208	50	0.049	Mouse
canonical wnt signaling pathway	GO:0060070	130	0.049	Mouse
locomotory behavior	GO:0007626	195	0.049
nephron tubule development	GO:0072080	84	0.049	Mouse
cartilage development	GO:0051216	140	0.048
regulation of ossification	GO:0030278	112	0.048
mesonephric tubule development	GO:0072164	94	0.048	Mouse
ossification	GO:0001503	216	0.048
muscle cell differentiation	GO:0042692	261	0.047	Mouse
connective tissue development	GO:0061448	179	0.047
nephron epithelium development	GO:0072009	92	0.047	Mouse
leukocyte migration	GO:0050900	124	0.047
organonitrogen compound catabolic process	GO:1901565	264	0.046
regionalization	GO:0003002	337	0.046	Mouse
regulation of system process	GO:0044057	200	0.046
mesenchymal cell differentiation	GO:0048762	107	0.046	Mouse
cellular response to growth factor stimulus	GO:0071363	197	0.046
palate development	GO:0060021	76	0.046
response to growth factor	GO:0070848	198	0.045
negative regulation of molecular function	GO:0044092	258	0.045	Mouse
cellular response to hormone stimulus	GO:0032870	150	0.045
ectoderm formation	GO:0001705	3	0.045	Mouse
regulation of establishment of protein localization	GO:0070201	181	0.045
bone development	GO:0060348	120	0.045
lymphocyte differentiation	GO:0030098	242	0.044
acute inflammatory response	GO:0002526	41	0.044
embryonic organ morphogenesis	GO:0048562	276	0.044	Mouse
fertilization	GO:0009566	127	0.044
mesonephric tubule morphogenesis	GO:0072171	63	0.044	Mouse
epithelial tube morphogenesis	GO:0060562	303	0.043	Mouse
positive regulation of cellular amine metabolic process	GO:0033240	5	0.043
response to organonitrogen compound	GO:0010243	246	0.043
central nervous system neuron differentiation	GO:0021953	162	0.043
regulation of cell migration	GO:0030334	219	0.043
extracellular structure organization	GO:0043062	148	0.043	Mouse
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002460	145	0.042
aromatic compound catabolic process	GO:0019439	286	0.042
purine nucleoside catabolic process	GO:0006152	205	0.042
ameboidal type cell migration	GO:0001667	128	0.042	Mouse
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.042
regulation of cell motility	GO:2000145	236	0.042
lymphocyte mediated immunity	GO:0002449	139	0.041
neural crest cell development	GO:0014032	48	0.041	Mouse
cerebral cortex gabaergic interneuron migration	GO:0021853	6	0.041	Mouse
regulation of membrane potential	GO:0042391	192	0.041
regulation of neuron differentiation	GO:0045664	281	0.041	Mouse
segmentation	GO:0035282	93	0.040	Mouse
pallium development	GO:0021543	120	0.040	Mouse
regulation of stem cell proliferation	GO:0072091	78	0.040
regulation of multi organism process	GO:0043900	111	0.040
limbic system development	GO:0021761	72	0.040	Mouse
forebrain development	GO:0030900	302	0.040
neuron migration	GO:0001764	122	0.039	Mouse
neural retina development	GO:0003407	41	0.039	Mouse
spermatogenesis	GO:0007283	284	0.039
urogenital system development	GO:0001655	261	0.039	Mouse
development of primary male sexual characteristics	GO:0046546	88	0.038	Mouse
metencephalon development	GO:0022037	89	0.038	Mouse
skeletal system development	GO:0001501	356	0.038	Mouse
innate immune response	GO:0045087	157	0.038
astrocyte fate commitment	GO:0060018	4	0.038
appendage morphogenesis	GO:0035107	149	0.038	Mouse
negative regulation of protein metabolic process	GO:0051248	282	0.037
cellular response to lipid	GO:0071396	145	0.037
positive regulation of auditory receptor cell differentiation	GO:0045609	1	0.037
actin filament based movement	GO:0030048	23	0.036
cytoplasmic transport	GO:0016482	234	0.036
cell differentiation in spinal cord	GO:0021515	53	0.036	Mouse
positive regulation of protein phosphorylation	GO:0001934	242	0.036	Mouse
nuclear transport	GO:0051169	139	0.036
ureteric bud morphogenesis	GO:0060675	62	0.036	Mouse
cellular response to cytokine stimulus	GO:0071345	189	0.036
cartilage development involved in endochondral bone morphogenesis	GO:0060351	24	0.036
morphogenesis of a branching structure	GO:0001763	203	0.036	Mouse
gland development	GO:0048732	330	0.035	Mouse
face morphogenesis	GO:0060325	29	0.035
cardiac muscle cell contraction	GO:0086003	7	0.035
regulation of auditory receptor cell differentiation	GO:0045607	4	0.035
morphogenesis of embryonic epithelium	GO:0016331	159	0.035	Mouse
heterocycle catabolic process	GO:0046700	280	0.035
cell proliferation in hindbrain	GO:0021534	10	0.035
organophosphate catabolic process	GO:0046434	232	0.034
nitrogen compound transport	GO:0071705	271	0.034
cellular homeostasis	GO:0019725	240	0.034
regulation of gliogenesis	GO:0014013	50	0.034
bone morphogenesis	GO:0060349	78	0.034
positive regulation of lymphocyte mediated immunity	GO:0002708	62	0.034
respiratory system development	GO:0060541	190	0.034
myeloid cell differentiation	GO:0030099	233	0.034
learning or memory	GO:0007611	148	0.033
regulation of protein transport	GO:0051223	163	0.033
protein localization to organelle	GO:0033365	185	0.033
subpallium development	GO:0021544	20	0.033
cellular response to organonitrogen compound	GO:0071417	145	0.032
regulation of response to wounding	GO:1903034	189	0.032	Mouse
primary neural tube formation	GO:0014020	95	0.032	Mouse
mesenchymal cell development	GO:0014031	93	0.032	Mouse
glycosyl compound metabolic process	GO:1901657	246	0.032
striated muscle tissue development	GO:0014706	293	0.032	Mouse
regulation of lymphocyte activation	GO:0051249	240	0.032
macromolecule catabolic process	GO:0009057	281	0.032
negative regulation of neuron death	GO:1901215	98	0.032	Mouse
somite development	GO:0061053	81	0.032	Mouse
g protein coupled receptor signaling pathway	GO:0007186	243	0.031
neural tube formation	GO:0001841	108	0.031	Mouse
cell proliferation involved in outflow tract morphogenesis	GO:0061325	4	0.031
dna metabolic process	GO:0006259	303	0.031
ventral spinal cord development	GO:0021517	48	0.031	Mouse
single organism cell adhesion	GO:0098602	156	0.031
substrate independent telencephalic tangential migration	GO:0021826	8	0.031	Mouse
negative regulation of nervous system development	GO:0051961	156	0.031	Mouse
nephron tubule morphogenesis	GO:0072078	68	0.030	Mouse
adult behavior	GO:0030534	135	0.030
astrocyte differentiation	GO:0048708	43	0.030
actin mediated cell contraction	GO:0070252	15	0.030
cellular nitrogen compound catabolic process	GO:0044270	280	0.030
apoptotic signaling pathway	GO:0097190	306	0.030
purine nucleoside metabolic process	GO:0042278	241	0.030
retina development in camera type eye	GO:0060041	119	0.030	Mouse
blastocyst development	GO:0001824	80	0.029
regulation of inflammatory response	GO:0050727	147	0.029	Mouse
response to organic cyclic compound	GO:0014070	198	0.029
kidney development	GO:0001822	213	0.029	Mouse
purine ribonucleoside metabolic process	GO:0046128	241	0.029
biomineral tissue development	GO:0031214	64	0.029
blood circulation	GO:0008015	195	0.028
organelle fission	GO:0048285	170	0.028
single organism nuclear import	GO:1902593	95	0.028
cellular amine metabolic process	GO:0044106	44	0.028
trachea cartilage morphogenesis	GO:0060535	4	0.028
nucleoside phosphate catabolic process	GO:1901292	222	0.028
dentate gyrus development	GO:0021542	14	0.028	Mouse
forebrain generation of neurons	GO:0021872	63	0.028
renal tubule morphogenesis	GO:0061333	72	0.028	Mouse
regulation of neuron projection development	GO:0010975	169	0.028
positive regulation of cell motility	GO:2000147	116	0.027
sensory perception	GO:0007600	245	0.027
limb morphogenesis	GO:0035108	149	0.027	Mouse
regulation of bmp signaling pathway	GO:0030510	60	0.027
establishment of protein localization to organelle	GO:0072594	118	0.027
limb development	GO:0060173	166	0.027	Mouse
body morphogenesis	GO:0010171	45	0.027
peptide transport	GO:0015833	133	0.027
b cell mediated immunity	GO:0019724	71	0.027
cellular response to organic cyclic compound	GO:0071407	87	0.027
diencephalon development	GO:0021536	63	0.026	Mouse
negative regulation of phosphorylation	GO:0042326	166	0.026
nephron development	GO:0072006	109	0.026	Mouse
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.026
single fertilization	GO:0007338	82	0.026
nucleocytoplasmic transport	GO:0006913	139	0.026
cerebellum development	GO:0021549	77	0.026	Mouse
heart morphogenesis	GO:0003007	178	0.026	Mouse
production of molecular mediator of immune response	GO:0002440	103	0.026
regulation of cell cycle	GO:0051726	281	0.026
nucleotide metabolic process	GO:0009117	332	0.026
purine ribonucleotide catabolic process	GO:0009154	208	0.025
negative regulation of cell proliferation	GO:0008285	296	0.025
ribonucleoside metabolic process	GO:0009119	245	0.025
immunoglobulin production	GO:0002377	73	0.025
maintenance of location	GO:0051235	89	0.025
neural tube closure	GO:0001843	90	0.025	Mouse
axon guidance	GO:0007411	141	0.025	Mouse
regulation of heart contraction	GO:0008016	77	0.025
endothelial cell differentiation	GO:0045446	41	0.025
chemotaxis	GO:0006935	247	0.025	Mouse
t cell activation	GO:0042110	289	0.025
multi multicellular organism process	GO:0044706	109	0.025
positive regulation of cell migration	GO:0030335	109	0.025
embryonic forelimb morphogenesis	GO:0035115	32	0.025
protein targeting	GO:0006605	143	0.024
nephron epithelium morphogenesis	GO:0072088	68	0.024	Mouse
regulation of cell activation	GO:0050865	289	0.024
organic cyclic compound catabolic process	GO:1901361	295	0.024
peptidyl amino acid modification	GO:0018193	336	0.024	Mouse
gonad development	GO:0008406	141	0.024
odontogenesis	GO:0042476	78	0.023
response to acid chemical	GO:0001101	111	0.023
cell division	GO:0051301	120	0.023
regulation of homeostatic process	GO:0032844	182	0.023
positive regulation of immune effector process	GO:0002699	107	0.023
endothelium development	GO:0003158	45	0.023
epithelial cell development	GO:0002064	159	0.023
regulation of osteoblast differentiation	GO:0045667	67	0.023
rhythmic process	GO:0048511	174	0.023
mesonephros development	GO:0001823	97	0.023	Mouse
response to lipopolysaccharide	GO:0032496	128	0.023
myotube differentiation	GO:0014902	105	0.023
cranial nerve development	GO:0021545	41	0.023	Mouse
positive regulation of secretion by cell	GO:1903532	114	0.023
digestion	GO:0007586	40	0.022
positive regulation of transcription from rna polymerase ii promoter involved in norepinephrine biosynthetic process	GO:2000763	1	0.022
purine nucleotide catabolic process	GO:0006195	211	0.022
positive regulation of stem cell proliferation	GO:2000648	59	0.022
placenta development	GO:0001890	140	0.022	Mouse
protein import into nucleus	GO:0006606	95	0.022
blood vessel morphogenesis	GO:0048514	285	0.022	Mouse
cellular response to transforming growth factor beta stimulus	GO:0071560	88	0.022
asymmetric neuroblast division	GO:0055059	1	0.022
protein catabolic process	GO:0030163	221	0.022
extracellular matrix organization	GO:0030198	147	0.022	Mouse
purine containing compound catabolic process	GO:0072523	213	0.022
regulation of interleukin 1 alpha production	GO:0032650	4	0.022	Mouse
regulation of intracellular transport	GO:0032386	159	0.022
dna recombination	GO:0006310	92	0.022
oviduct development	GO:0060066	3	0.022	Mouse
chondrocyte development	GO:0002063	24	0.022
mesenchyme development	GO:0060485	152	0.022	Mouse
positive regulation of peptidyl tyrosine phosphorylation	GO:0050731	61	0.022	Mouse
response to steroid hormone	GO:0048545	56	0.022
nucleobase containing small molecule metabolic process	GO:0055086	352	0.021
spinal cord development	GO:0021510	81	0.021	Mouse
positive regulation of ossification	GO:0045778	47	0.021
cardiac ventricle development	GO:0003231	83	0.021	Mouse
subpallium neuron fate commitment	GO:0060163	2	0.021
pituitary gland development	GO:0021983	38	0.021	Mouse
olfactory lobe development	GO:0021988	32	0.021	Mouse
auditory receptor cell fate determination	GO:0042668	3	0.021
regulation of protein catabolic process	GO:0042176	108	0.021
positive regulation of cytokine production	GO:0001819	174	0.021	Mouse
antimicrobial peptide biosynthetic process	GO:0002777	2	0.021
cerebral cortex gabaergic interneuron differentiation	GO:0021892	9	0.021	Mouse
regulation of wnt signaling pathway	GO:0030111	123	0.021	Mouse
olfactory bulb development	GO:0021772	30	0.021	Mouse
fat cell differentiation	GO:0045444	160	0.021
regulation of glial cell differentiation	GO:0045685	41	0.021
stem cell development	GO:0048864	219	0.021	Mouse
cerebellar cortex development	GO:0021695	48	0.021	Mouse
nephron morphogenesis	GO:0072028	69	0.021	Mouse
erythrocyte differentiation	GO:0030218	88	0.021
neural crest cell migration	GO:0001755	32	0.021	Mouse
negative regulation of glial cell differentiation	GO:0045686	21	0.020
protein kinase b signaling	GO:0043491	74	0.020
cellular response to acid chemical	GO:0071229	68	0.020
protein localization to nucleus	GO:0034504	121	0.020
b cell activation	GO:0042113	161	0.020
meiotic cell cycle	GO:0051321	122	0.020
transdifferentiation	GO:0060290	1	0.020
mesenchymal cell proliferation	GO:0010463	44	0.020
protein modification by small protein conjugation or removal	GO:0070647	207	0.020
negative regulation of gliogenesis	GO:0014014	23	0.020
cardiac neural crest cell migration involved in outflow tract morphogenesis	GO:0003253	3	0.020
negative regulation of neuron apoptotic process	GO:0043524	92	0.020	Mouse
negative regulation of bmp signaling pathway	GO:0030514	35	0.020
hindbrain morphogenesis	GO:0021575	46	0.020	Mouse
cell adhesion	GO:0007155	329	0.020
regulation of transferase activity	GO:0051338	263	0.020
neural crest cell differentiation	GO:0014033	54	0.020	Mouse
regulation of astrocyte differentiation	GO:0048710	20	0.020
neural tube development	GO:0021915	160	0.020	Mouse
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.020
regulation of exit from mitosis	GO:0007096	1	0.020
nuclear division	GO:0000280	158	0.020
endocardial cushion morphogenesis	GO:0003203	18	0.020	Mouse
head morphogenesis	GO:0060323	34	0.020
branching morphogenesis of an epithelial tube	GO:0048754	159	0.019	Mouse
negative regulation of blood vessel endothelial cell migration	GO:0043537	3	0.019
nucleoside triphosphate metabolic process	GO:0009141	230	0.019
organic hydroxy compound metabolic process	GO:1901615	203	0.019
regulation of protein maturation	GO:1903317	96	0.019
positive regulation of neural precursor cell proliferation	GO:2000179	42	0.019	Mouse
nucleoside phosphate metabolic process	GO:0006753	338	0.019
skeletal muscle organ development	GO:0060538	163	0.019
germ cell development	GO:0007281	185	0.019
male sex differentiation	GO:0046661	109	0.019	Mouse
protein modification by small protein conjugation	GO:0032446	187	0.019
positive regulation of apoptotic signaling pathway	GO:2001235	95	0.019
tube formation	GO:0035148	140	0.019	Mouse
kidney morphogenesis	GO:0060993	83	0.019	Mouse
adaptive immune response	GO:0002250	155	0.019
carbon catabolite repression of transcription from rna polymerase ii promoter	GO:0000437	1	0.019
positive regulation of adaptive immune response	GO:0002821	61	0.019
response to oxidative stress	GO:0006979	123	0.019
nucleoside triphosphate catabolic process	GO:0009143	205	0.019
muscle fiber development	GO:0048747	76	0.019
cellular macromolecule catabolic process	GO:0044265	206	0.019
sensory organ morphogenesis	GO:0090596	242	0.019	Mouse
regulation of peptidase activity	GO:0052547	96	0.019
spinal cord motor neuron differentiation	GO:0021522	35	0.018	Mouse
interferon gamma production	GO:0032609	67	0.018	Mouse
positive regulation of keratinocyte proliferation	GO:0010838	4	0.018
positive regulation of mesonephros development	GO:0061213	20	0.018	Mouse
compound eye development	GO:0048749	1	0.018	Fly
gastrin induced gastric acid secretion	GO:0001698	1	0.018
positive regulation of kinase activity	GO:0033674	155	0.018
antimicrobial peptide production	GO:0002775	2	0.018
retina morphogenesis in camera type eye	GO:0060042	45	0.018	Mouse
regulation of retina development in camera type eye	GO:1902866	3	0.018
positive regulation of transcription from rna polymerase ii promoter involved in myocardial precursor cell differentiation	GO:0003257	3	0.018
growth plate cartilage development	GO:0003417	14	0.018
oxidation reduction process	GO:0055114	342	0.018
nucleotide catabolic process	GO:0009166	217	0.018
second messenger mediated signaling	GO:0019932	73	0.018
purine nucleotide metabolic process	GO:0006163	302	0.018
peptidyl tyrosine modification	GO:0018212	145	0.018	Mouse
protein secretion	GO:0009306	111	0.018
t cell differentiation	GO:0030217	174	0.018
positive regulation of nervous system development	GO:0051962	221	0.018	Mouse
regulation of protein kinase b signaling	GO:0051896	56	0.017
mesonephric epithelium development	GO:0072163	94	0.017	Mouse
nuclear import	GO:0051170	95	0.017
negative regulation of cellular amino acid metabolic process	GO:0045763	0	0.017
regulation of cytoplasmic transport	GO:1903649	112	0.017
atp metabolic process	GO:0046034	75	0.017
hemangioblast cell differentiation	GO:0060217	1	0.017
male gonad development	GO:0008584	88	0.017	Mouse
adult locomotory behavior	GO:0008344	91	0.017
respiratory system process	GO:0003016	25	0.017
purine ribonucleoside catabolic process	GO:0046130	205	0.017
myeloid cell homeostasis	GO:0002262	114	0.017
circulatory system process	GO:0003013	197	0.017
response to oxygen levels	GO:0070482	62	0.017
humoral immune response	GO:0006959	57	0.017
ear morphogenesis	GO:0042471	118	0.017
embryonic heart tube formation	GO:0003144	1	0.017
carbohydrate derivative catabolic process	GO:1901136	231	0.017
positive regulation of cell cycle	GO:0045787	92	0.017
regulation of blood pressure	GO:0008217	93	0.016
negative regulation of cellular amine metabolic process	GO:0033239	1	0.016
regulation of cellular catabolic process	GO:0031329	242	0.016
inflammatory response	GO:0006954	244	0.016	Mouse
carbohydrate homeostasis	GO:0033500	128	0.016
central nervous system neuron development	GO:0021954	67	0.016
male gamete generation	GO:0048232	285	0.016
motor neuron axon guidance	GO:0008045	26	0.016	Mouse
hormone secretion	GO:0046879	128	0.016
lateral motor column neuron migration	GO:0097477	3	0.016	Mouse
translation	GO:0006412	93	0.016
purine containing compound metabolic process	GO:0072521	311	0.016
negative regulation of endothelial cell migration	GO:0010596	4	0.016
regulation of protein kinase activity	GO:0045859	232	0.016
endodermal cell fate specification	GO:0001714	4	0.016
ribonucleotide catabolic process	GO:0009261	208	0.016
negative regulation of cellular protein metabolic process	GO:0032269	247	0.016
cytokine secretion	GO:0050663	72	0.016
negative regulation of multi organism process	GO:0043901	68	0.016
learning	GO:0007612	98	0.016
neuroblast proliferation	GO:0007405	49	0.016
endochondral bone morphogenesis	GO:0060350	50	0.016
regulation of mast cell differentiation	GO:0060375	3	0.016
antibacterial peptide biosynthetic process	GO:0002780	2	0.016
anion transport	GO:0006820	177	0.016
defense response to other organism	GO:0098542	197	0.016
blastocyst formation	GO:0001825	33	0.016
negative regulation of secretion	GO:0051048	61	0.016
skeletal muscle fiber development	GO:0048741	58	0.016
sensory perception of sound	GO:0007605	97	0.016
regulation of cell morphogenesis involved in differentiation	GO:0010769	151	0.016
positive regulation of cellular catabolic process	GO:0031331	148	0.016
inorganic ion transmembrane transport	GO:0098660	234	0.016
nucleoside catabolic process	GO:0009164	206	0.016
sensory perception of mechanical stimulus	GO:0050954	107	0.016
positive regulation of response to wounding	GO:1903036	66	0.016
regulation of biomineral tissue development	GO:0070167	33	0.015
embryonic epithelial tube formation	GO:0001838	130	0.015	Mouse
odontogenesis of dentin containing tooth	GO:0042475	66	0.015
cardiac cell fate determination	GO:0060913	2	0.015	Mouse
regulation of microvillus organization	GO:0032530	3	0.015
telencephalon cell migration	GO:0022029	55	0.015	Mouse
regulation of myotube differentiation	GO:0010830	62	0.015
regulation of fat cell differentiation	GO:0045598	81	0.015
cerebellum morphogenesis	GO:0021587	42	0.015	Mouse
appendage development	GO:0048736	166	0.015	Mouse
peripheral nervous system neuron axonogenesis	GO:0048936	3	0.015	Mouse
regulation of renal sodium excretion	GO:0035813	3	0.015
regulation of secretion	GO:0051046	274	0.015
regulation of muscle system process	GO:0090257	80	0.015
positive regulation of hydrolase activity	GO:0051345	148	0.015
ribonucleoside triphosphate catabolic process	GO:0009203	199	0.015
wnt signaling pathway	GO:0016055	188	0.015	Mouse
regulation of canonical wnt signaling pathway	GO:0060828	82	0.015	Mouse
regulation of lipid metabolic process	GO:0019216	118	0.015
respiratory gaseous exchange	GO:0007585	43	0.015
regulation of kinase activity	GO:0043549	249	0.015
ion transmembrane transport	GO:0034220	361	0.015
regulation of cytokine production	GO:0001817	266	0.015	Mouse
forebrain neuron fate commitment	GO:0021877	13	0.015	Mouse
embryonic limb morphogenesis	GO:0030326	126	0.014
rhombomere 5 development	GO:0021571	4	0.014
myotube cell development	GO:0014904	60	0.014
positive regulation of mechanoreceptor differentiation	GO:0045633	1	0.014
regulation of binding	GO:0051098	111	0.014	Mouse
regulation of blood circulation	GO:1903522	93	0.014
dorsal spinal cord development	GO:0021516	20	0.014	Mouse
regulation of cellular component biogenesis	GO:0044087	181	0.014
face development	GO:0060324	38	0.014
positive regulation of protein kinase activity	GO:0045860	144	0.014
positive regulation of heart rate by epinephrine norepinephrine	GO:0001996	4	0.014
negative regulation of cell migration	GO:0030336	59	0.014
regulation of proteolysis	GO:0030162	164	0.014
metanephric nephron morphogenesis	GO:0072273	19	0.014	Mouse
regulation of endocardial cushion to mesenchymal transition involved in heart valve formation	GO:2000800	1	0.014
amide transport	GO:0042886	138	0.014
tissue remodeling	GO:0048771	102	0.014
mammary gland epithelium development	GO:0061180	65	0.014
regulation of neural retina development	GO:0061074	3	0.014
regulation of nucleotide catabolic process	GO:0030811	122	0.014
cardiac muscle cell differentiation	GO:0055007	69	0.014
embryonic skeletal system morphogenesis	GO:0048704	91	0.014	Mouse
definitive hemopoiesis	GO:0060216	20	0.014
regulation of heart rate	GO:0002027	36	0.014
regulation of striated muscle cell differentiation	GO:0051153	81	0.014
positive regulation of cytoplasmic transport	GO:1903651	40	0.014
mechanoreceptor differentiation	GO:0042490	67	0.014
semaphorin plexin signaling pathway involved in outflow tract morphogenesis	GO:0071527	1	0.014
cardiac atrium development	GO:0003230	24	0.014	Mouse
peptidyl tyrosine phosphorylation	GO:0018108	143	0.014	Mouse
carbohydrate derivative biosynthetic process	GO:1901137	183	0.014
regulation of ion transport	GO:0043269	215	0.014
epithelial tube formation	GO:0072175	130	0.014	Mouse
positive regulation of homeostatic process	GO:0032846	64	0.014
regulation of angiotensin metabolic process	GO:0060177	4	0.014
regulation of protein stability	GO:0031647	52	0.014
regulation of nucleocytoplasmic transport	GO:0046822	73	0.014
regulation of defense response	GO:0031347	233	0.014	Mouse
ureteric bud development	GO:0001657	94	0.014	Mouse
hippocampus development	GO:0021766	52	0.014	Mouse
carbohydrate metabolic process	GO:0005975	230	0.014
positive regulation of protein transport	GO:0051222	93	0.014
purine nucleoside monophosphate metabolic process	GO:0009126	81	0.014
cell cell signaling involved in mammary gland development	GO:0060764	2	0.014
metanephric loop of henle development	GO:0072236	4	0.014

Lhx8 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	musculoskeletal system disease	DOID:17	0	0.014
	disease of anatomical entity	DOID:7	0	0.014

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