IMP: Integrative Multi-species Prediction

Mus musculus

147 known processes

Bcl2l1

BCL2-like 1

(Aliases: Bcl(X)L,Bcl-Xs,MGC99998,bcl-x,BclX,Bcl-XL,Bcl2l,MGC113803)

Entrez: 12048
Ensembl: ENSMUSG00000007659
UniProtKB: O35843
UniProtKB: Q5HZH3
UniProtKB: Q64373

Process Predictions
Disease Predictions

Bcl2l1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
positive regulation of mitochondrial membrane permeability involved in apoptotic process	GO:1902110	11	0.971	Mouse
mitochondrial outer membrane permeabilization involved in programmed cell death	GO:1902686	11	0.958	Mouse
response to endoplasmic reticulum stress	GO:0034976	53	0.857	Mouse
apoptotic mitochondrial changes	GO:0008637	48	0.825
regulation of mitochondrion organization	GO:0010821	27	0.807	Human Worm
intrinsic apoptotic signaling pathway in response to dna damage	GO:0008630	57	0.762
apoptotic signaling pathway	GO:0097190	306	0.721
cellular response to dna damage stimulus	GO:0006974	207	0.652
positive regulation of mitochondrial membrane permeability	GO:0035794	12	0.551	Mouse
mitochondrial membrane organization	GO:0007006	26	0.546	Human Mouse
regulation of membrane permeability	GO:0090559	18	0.545	Human Mouse
regulation of apoptotic signaling pathway	GO:2001233	197	0.522	Human Zebrafish Mouse
mitochondrion organization	GO:0007005	134	0.518
intrinsic apoptotic signaling pathway	GO:0097193	132	0.462
positive regulation of peptidase activity	GO:0010952	49	0.462	Mouse
cellular response to radiation	GO:0071478	28	0.444
regulation of mitochondrial membrane permeability	GO:0046902	17	0.439	Human Mouse
mitochondrial transport	GO:0006839	36	0.432	Human Mouse
positive regulation of cell death	GO:0010942	224	0.318
signal transduction by p53 class mediator	GO:0072331	51	0.318	Mouse
regulation of proteolysis	GO:0030162	164	0.300	Zebrafish Mouse
amine metabolic process	GO:0009308	45	0.297
protein insertion into mitochondrial membrane involved in apoptotic signaling pathway	GO:0001844	4	0.276	Mouse
neuron death	GO:0070997	154	0.274
cellular response to gamma radiation	GO:0071480	4	0.266
regulation of cell cycle	GO:0051726	281	0.266
positive regulation of endopeptidase activity	GO:0010950	43	0.249	Mouse
thymocyte apoptotic process	GO:0070242	19	0.241	Mouse
mitochondrial outer membrane permeabilization	GO:0097345	10	0.234	Mouse
regulation of endopeptidase activity	GO:0052548	89	0.229	Zebrafish Mouse
response to radiation	GO:0009314	165	0.227
positive regulation of apoptotic process	GO:0043065	217	0.221
release of cytochrome c from mitochondria	GO:0001836	23	0.220
extrinsic apoptotic signaling pathway	GO:0097191	126	0.220
protein localization to organelle	GO:0033365	185	0.220	Mouse
regulation of neuron apoptotic process	GO:0043523	122	0.219
response to ionizing radiation	GO:0010212	42	0.210
cellular protein catabolic process	GO:0044257	155	0.210
regulation of neuron death	GO:1901214	134	0.209
positive regulation of programmed cell death	GO:0043068	218	0.208
cell type specific apoptotic process	GO:0097285	268	0.205
macromolecule catabolic process	GO:0009057	281	0.205
modification dependent macromolecule catabolic process	GO:0043632	133	0.184
positive regulation of lymphocyte apoptotic process	GO:0070230	13	0.183	Mouse
positive regulation of hydrolase activity	GO:0051345	148	0.181	Mouse Worm
male gamete generation	GO:0048232	285	0.181
spermatogenesis	GO:0007283	284	0.170
regulation of transferase activity	GO:0051338	263	0.168
regulation of cellular ketone metabolic process	GO:0010565	66	0.167
regulation of organelle organization	GO:0033043	289	0.162	Human Worm
leukocyte apoptotic process	GO:0071887	71	0.158	Mouse
regulation of cysteine type endopeptidase activity	GO:2000116	65	0.155	Zebrafish Mouse
positive regulation of intracellular transport	GO:0032388	70	0.148	Mouse
regulation of protein localization	GO:0032880	231	0.144	Human Mouse
myeloid cell homeostasis	GO:0002262	114	0.138	Mouse
positive regulation of proteolysis	GO:0045862	85	0.137	Mouse
regulation of leukocyte apoptotic process	GO:2000106	56	0.136	Mouse
lymphocyte apoptotic process	GO:0070227	54	0.134	Mouse
regulation of cellular response to stress	GO:0080135	159	0.134	Human Mouse
protein catabolic process	GO:0030163	221	0.132
protein maturation	GO:0051604	176	0.132	Zebrafish Mouse
cellular lipid metabolic process	GO:0044255	323	0.130	Mouse
response to oxidative stress	GO:0006979	123	0.129	Mouse
regulation of cellular catabolic process	GO:0031329	242	0.128	Worm
membrane organization	GO:0061024	245	0.127	Human Mouse Worm
regulation of intrinsic apoptotic signaling pathway	GO:2001242	61	0.127	Human Zebrafish Mouse
reactive oxygen species metabolic process	GO:0072593	84	0.123	Mouse
negative regulation of cell proliferation	GO:0008285	296	0.119	Mouse
positive regulation of leukocyte apoptotic process	GO:2000108	21	0.119	Mouse
peptidyl amino acid modification	GO:0018193	336	0.118	Mouse
negative regulation of cell cycle	GO:0045786	123	0.118	Human Mouse
protein processing	GO:0016485	163	0.118	Zebrafish Mouse
cellular homeostasis	GO:0019725	240	0.116	Mouse
purine nucleotide metabolic process	GO:0006163	302	0.115	Worm
regulation of lymphocyte apoptotic process	GO:0070228	41	0.115	Mouse
regulation of hydrolase activity	GO:0051336	246	0.115	Zebrafish Mouse Worm
interspecies interaction between organisms	GO:0044419	83	0.114	Human Mouse
cell adhesion	GO:0007155	329	0.113	Mouse
positive regulation of neuron death	GO:1901216	28	0.112	Mouse
negative regulation of protein phosphorylation	GO:0001933	126	0.110	Mouse
germ cell development	GO:0007281	185	0.109
positive regulation of protein modification process	GO:0031401	299	0.108	Mouse
muscle tissue development	GO:0060537	308	0.108	Mouse
protein localization to membrane	GO:0072657	108	0.108	Human Mouse
positive regulation of neuron apoptotic process	GO:0043525	25	0.106	Mouse
protein modification by small protein conjugation	GO:0032446	187	0.106
carbohydrate derivative biosynthetic process	GO:1901137	183	0.105	Mouse
cellular amino acid metabolic process	GO:0006520	103	0.105
small gtpase mediated signal transduction	GO:0007264	97	0.105
regulation of cellular amine metabolic process	GO:0033238	20	0.105
negative regulation of cellular amine metabolic process	GO:0033239	1	0.103
mitotic cell cycle	GO:0000278	195	0.103	Human Mouse
regulation of kinase activity	GO:0043549	249	0.102
purine ribonucleotide metabolic process	GO:0009150	290	0.101	Worm
ras protein signal transduction	GO:0007265	77	0.100
positive regulation of macroautophagy	GO:0016239	3	0.099
protein insertion into mitochondrial membrane	GO:0051204	4	0.099	Mouse
cellular macromolecule catabolic process	GO:0044265	206	0.098
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.098
regulation of multi organism process	GO:0043900	111	0.093	Mouse
cell growth	GO:0016049	130	0.091	Mouse
ribonucleoside triphosphate catabolic process	GO:0009203	199	0.091	Worm
organelle assembly	GO:0070925	177	0.090
camera type eye development	GO:0043010	266	0.090	Mouse
intrinsic apoptotic signaling pathway by p53 class mediator	GO:0072332	35	0.089	Mouse
cellular response to oxidative stress	GO:0034599	76	0.088	Mouse
positive regulation of protein phosphorylation	GO:0001934	242	0.088	Mouse
actin cytoskeleton organization	GO:0030036	220	0.088	Mouse
cellular ketone metabolic process	GO:0042180	84	0.087
negative regulation of protein metabolic process	GO:0051248	282	0.085	Zebrafish Mouse
regulation of establishment of protein localization	GO:0070201	181	0.085	Human
negative regulation of phosphorus metabolic process	GO:0010563	184	0.085	Mouse
cellular amine metabolic process	GO:0044106	44	0.084
negative regulation of cellular amino acid metabolic process	GO:0045763	0	0.084
dna metabolic process	GO:0006259	303	0.084
cation transport	GO:0006812	399	0.084	Mouse
t cell apoptotic process	GO:0070231	39	0.084	Mouse
single organism cell adhesion	GO:0098602	156	0.083	Mouse
positive regulation of organelle organization	GO:0010638	128	0.083	Worm
positive regulation of mitochondrion organization	GO:0010822	17	0.082	Worm
regulation of mitotic cell cycle	GO:0007346	126	0.080	Human Mouse
cellular response to abiotic stimulus	GO:0071214	56	0.080
muscle cell differentiation	GO:0042692	261	0.080	Mouse
negative regulation of phosphorylation	GO:0042326	166	0.080	Mouse
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	GO:1901030	6	0.079
regulation of cellular amino acid metabolic process	GO:0006521	5	0.078
proteolysis involved in cellular protein catabolic process	GO:0051603	147	0.077
aromatic compound catabolic process	GO:0019439	286	0.077	Worm
regulation of membrane potential	GO:0042391	192	0.076	Human Mouse
nucleoside phosphate metabolic process	GO:0006753	338	0.075	Worm
single organismal cell cell adhesion	GO:0016337	131	0.074	Mouse
cytoplasmic transport	GO:0016482	234	0.074	Mouse
positive regulation of cellular amine metabolic process	GO:0033240	5	0.073
negative regulation of molecular function	GO:0044092	258	0.072	Zebrafish
myotube differentiation	GO:0014902	105	0.071	Mouse
cell substrate adhesion	GO:0031589	130	0.070	Mouse
response to ischemia	GO:0002931	14	0.070	Mouse
regulation of protein serine threonine kinase activity	GO:0071900	157	0.069
dephosphorylation	GO:0016311	129	0.069	Mouse
neuron apoptotic process	GO:0051402	142	0.069
regulation of protein kinase activity	GO:0045859	232	0.069
ribonucleoside metabolic process	GO:0009119	245	0.068	Worm
nucleotide metabolic process	GO:0009117	332	0.067	Worm
guanosine containing compound catabolic process	GO:1901069	144	0.067	Worm
cell matrix adhesion	GO:0007160	68	0.067	Mouse
epithelial tube morphogenesis	GO:0060562	303	0.067	Mouse
maintenance of location	GO:0051235	89	0.066
microtubule cytoskeleton organization	GO:0000226	157	0.065
glycoprotein biosynthetic process	GO:0009101	89	0.064	Mouse
regulation of intracellular transport	GO:0032386	159	0.064	Mouse
positive regulation of release of cytochrome c from mitochondria	GO:0090200	5	0.064
purine nucleotide catabolic process	GO:0006195	211	0.064	Worm
olfactory learning	GO:0008355	2	0.063
activation of cysteine type endopeptidase activity	GO:0097202	27	0.063	Mouse
negative regulation of cellular protein metabolic process	GO:0032269	247	0.062	Zebrafish Mouse
positive regulation of apoptotic process involved in mammary gland involution	GO:0060058	4	0.062	Mouse
establishment of protein localization to membrane	GO:0090150	54	0.061	Human Mouse
transmembrane transport	GO:0055085	412	0.061
homeostasis of number of cells	GO:0048872	210	0.060	Mouse
protein ubiquitination	GO:0016567	171	0.060
microtubule based process	GO:0007017	236	0.060
protein modification by small protein conjugation or removal	GO:0070647	207	0.059
nucleobase containing small molecule metabolic process	GO:0055086	352	0.058	Worm
negative regulation of phosphate metabolic process	GO:0045936	184	0.058	Mouse
glycosyl compound metabolic process	GO:1901657	246	0.058	Worm
protein localization to mitochondrion	GO:0070585	15	0.057	Mouse
regulation of epithelial cell proliferation	GO:0050678	141	0.057	Mouse
response to inorganic substance	GO:0010035	96	0.057	Mouse
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.055	Human Zebrafish Mouse
gtp catabolic process	GO:0006184	143	0.055	Worm
positive regulation of protein oligomerization	GO:0032461	4	0.054
stem cell differentiation	GO:0048863	268	0.054	Mouse
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.054	Worm
regulation of cell motility	GO:2000145	236	0.053	Mouse
nucleoside metabolic process	GO:0009116	246	0.053	Worm
hematopoietic progenitor cell differentiation	GO:0002244	143	0.053	Mouse
angiogenesis	GO:0001525	201	0.053	Mouse
cellular response to growth factor stimulus	GO:0071363	197	0.053
modification dependent protein catabolic process	GO:0019941	133	0.052
regulation of symbiosis encompassing mutualism through parasitism	GO:0043903	52	0.052	Mouse
regulation of cell cycle process	GO:0010564	160	0.052	Human Mouse
sphingolipid metabolic process	GO:0006665	45	0.052	Mouse
glycoprotein metabolic process	GO:0009100	116	0.051	Mouse
symbiosis encompassing mutualism through parasitism	GO:0044403	83	0.051	Human Mouse
positive regulation of apoptotic signaling pathway	GO:2001235	95	0.051	Mouse
regulation of organ morphogenesis	GO:2000027	144	0.051	Mouse
negative regulation of protein modification process	GO:0031400	163	0.050	Mouse
positive regulation of cell motility	GO:2000147	116	0.050	Mouse
skeletal system development	GO:0001501	356	0.050
regulation of protein oligomerization	GO:0032459	4	0.049
response to growth factor	GO:0070848	198	0.049
regulation of reactive oxygen species metabolic process	GO:2000377	40	0.049
rho protein signal transduction	GO:0007266	32	0.049
regulation of mapk cascade	GO:0043408	248	0.049
gland development	GO:0048732	330	0.049	Zebrafish Mouse
oxidation reduction process	GO:0055114	342	0.048
negative regulation of mitotic cell cycle phase transition	GO:1901991	45	0.048	Human Mouse
skeletal muscle organ development	GO:0060538	163	0.048	Mouse
cellular ion homeostasis	GO:0006873	165	0.047	Mouse
cellular response to ionizing radiation	GO:0071479	11	0.047
male sex differentiation	GO:0046661	109	0.047
ubiquitin dependent protein catabolic process	GO:0006511	129	0.047
hindbrain development	GO:0030902	128	0.047	Mouse
negative regulation of growth	GO:0045926	99	0.047	Mouse
purine containing compound catabolic process	GO:0072523	213	0.046	Worm
axonogenesis	GO:0007409	274	0.046	Mouse
multicellular organismal homeostasis	GO:0048871	164	0.046	Zebrafish Mouse
positive regulation of transferase activity	GO:0051347	167	0.046
sensory organ morphogenesis	GO:0090596	242	0.046	Mouse
negative regulation of neuron death	GO:1901215	98	0.046
negative regulation of mitotic cell cycle	GO:0045930	58	0.045	Human Mouse
regulation of cell activation	GO:0050865	289	0.045
glial cell apoptotic process	GO:0034349	3	0.045
regulation of lymphocyte activation	GO:0051249	240	0.045
regulation of body fluid levels	GO:0050878	162	0.044
chemotaxis	GO:0006935	247	0.044
ossification	GO:0001503	216	0.044	Mouse
regulation of cell growth	GO:0001558	91	0.044	Mouse
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.044	Worm
ribonucleotide metabolic process	GO:0009259	291	0.043	Worm
positive regulation of cell migration	GO:0030335	109	0.043	Mouse
establishment or maintenance of cytoskeleton polarity	GO:0030952	2	0.043
regulation of mammary gland involution	GO:1903519	4	0.043	Mouse
modification by symbiont of host morphology or physiology	GO:0044003	4	0.043	Human
positive regulation of intrinsic apoptotic signaling pathway	GO:2001244	25	0.043	Mouse
immune response activating signal transduction	GO:0002757	116	0.043
muscle cell development	GO:0055001	133	0.043	Mouse
fibroblast proliferation	GO:0048144	35	0.043	Mouse
response to reactive oxygen species	GO:0000302	56	0.043	Mouse
response to hypoxia	GO:0001666	58	0.042	Mouse
organelle fission	GO:0048285	170	0.042
regulation of t cell activation	GO:0050863	170	0.042
leukocyte differentiation	GO:0002521	342	0.042	Mouse
cellular divalent inorganic cation homeostasis	GO:0072503	127	0.042	Mouse
urogenital system development	GO:0001655	261	0.042	Mouse
activation of immune response	GO:0002253	138	0.041
molting cycle	GO:0042303	90	0.041	Mouse
response to organonitrogen compound	GO:0010243	246	0.041
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.041	Worm
regulation of mitotic cell cycle phase transition	GO:1901990	73	0.041	Human Mouse
t cell differentiation in thymus	GO:0033077	77	0.041	Mouse
multicellular organism growth	GO:0035264	161	0.041	Mouse
purine ribonucleoside metabolic process	GO:0046128	241	0.040	Worm
neuron migration	GO:0001764	122	0.040	Mouse
pigmentation	GO:0043473	71	0.040	Mouse
modulation by virus of host morphology or physiology	GO:0019048	3	0.040	Human
response to oxygen levels	GO:0070482	62	0.040	Mouse
regulation of nucleocytoplasmic transport	GO:0046822	73	0.040
regulation of binding	GO:0051098	111	0.040
positive regulation of cellular catabolic process	GO:0031331	148	0.039	Worm
regulation of peptidase activity	GO:0052547	96	0.039	Zebrafish Mouse
positive regulation of cell cycle	GO:0045787	92	0.039
nucleoside phosphate catabolic process	GO:1901292	222	0.039	Worm
purine ribonucleotide catabolic process	GO:0009154	208	0.039	Worm
activation of cysteine type endopeptidase activity involved in apoptotic signaling pathway	GO:0097296	2	0.039	Mouse
regulation of release of cytochrome c from mitochondria	GO:0090199	11	0.039	Human
negative regulation of cell cycle process	GO:0010948	69	0.038	Human Mouse
regulation of cell adhesion	GO:0030155	154	0.038	Mouse
regulation of cellular component biogenesis	GO:0044087	181	0.038
cell cycle checkpoint	GO:0000075	47	0.038	Human
regulation of nucleotide metabolic process	GO:0006140	169	0.038	Worm
signal transduction in absence of ligand	GO:0038034	55	0.038
regulation of purine nucleotide metabolic process	GO:1900542	169	0.038	Worm
apoptotic process involved in mammary gland involution	GO:0060057	4	0.038	Mouse
vesicle organization	GO:0016050	60	0.038	Mouse
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway	GO:1900740	3	0.038
leukocyte proliferation	GO:0070661	172	0.038	Mouse
negative regulation of intracellular signal transduction	GO:1902532	167	0.037	Human Zebrafish
positive regulation of apoptotic process involved in morphogenesis	GO:1902339	4	0.037	Mouse
viral process	GO:0016032	41	0.037	Human Mouse
autophagy	GO:0006914	45	0.037
purine nucleoside metabolic process	GO:0042278	241	0.037	Worm
negative regulation of kinase activity	GO:0033673	81	0.037
anatomical structure homeostasis	GO:0060249	145	0.036	Zebrafish Mouse
glycosyl compound catabolic process	GO:1901658	206	0.036	Worm
mammary gland epithelium development	GO:0061180	65	0.036	Mouse
endoplasmic reticulum calcium ion homeostasis	GO:0032469	11	0.036	Mouse
regionalization	GO:0003002	337	0.036
t cell activation	GO:0042110	289	0.036	Mouse
rhythmic process	GO:0048511	174	0.036
positive regulation of homeostatic process	GO:0032846	64	0.036	Mouse
digestive system development	GO:0055123	200	0.036	Mouse
regulation of ossification	GO:0030278	112	0.036	Mouse
fat cell differentiation	GO:0045444	160	0.036
positive regulation of nucleotide metabolic process	GO:0045981	114	0.036	Worm
activation of cysteine type endopeptidase activity involved in apoptotic process	GO:0006919	27	0.035	Mouse
blood vessel morphogenesis	GO:0048514	285	0.035	Mouse
regulation of homeostatic process	GO:0032844	182	0.035	Mouse
extrinsic apoptotic signaling pathway in absence of ligand	GO:0097192	55	0.035
regulation of cell killing	GO:0031341	40	0.035
cell aging	GO:0007569	35	0.035	Mouse
epithelial cell proliferation	GO:0050673	174	0.035	Mouse
embryonic organ morphogenesis	GO:0048562	276	0.035
ribonucleotide catabolic process	GO:0009261	208	0.035	Worm
regulation of leukocyte differentiation	GO:1902105	159	0.035
cellular chemical homeostasis	GO:0055082	215	0.035	Mouse
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.034
positive regulation of purine nucleotide metabolic process	GO:1900544	114	0.034	Worm
positive regulation of protein kinase activity	GO:0045860	144	0.034
inflammatory response	GO:0006954	244	0.034
positive regulation of cell killing	GO:0031343	33	0.034
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	112	0.034
regulation of ras protein signal transduction	GO:0046578	114	0.034
appendage development	GO:0048736	166	0.034	Mouse
cellular nitrogen compound catabolic process	GO:0044270	280	0.034	Worm
endomembrane system organization	GO:0010256	147	0.034	Human
cell cell junction organization	GO:0045216	72	0.033	Mouse
ribonucleoside catabolic process	GO:0042454	206	0.033	Worm
nucleoside catabolic process	GO:0009164	206	0.033	Worm
chromatin organization	GO:0006325	206	0.033
positive regulation of skeletal muscle fiber development	GO:0048743	3	0.033	Mouse
renal system development	GO:0072001	225	0.033	Mouse
cell junction assembly	GO:0034329	52	0.033	Mouse
spermatid differentiation	GO:0048515	115	0.033	Mouse
cellular process regulating host cell cycle in response to virus	GO:0060154	3	0.033
regulation of purine nucleotide catabolic process	GO:0033121	122	0.033	Worm
signal transduction involved in mitotic dna damage checkpoint	GO:1902402	3	0.033
compound eye development	GO:0048749	1	0.033
carbohydrate derivative catabolic process	GO:1901136	231	0.032	Worm
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	88	0.032
regulation of b cell apoptotic process	GO:0002902	13	0.032	Mouse
purine ribonucleoside catabolic process	GO:0046130	205	0.032	Worm
nitrogen compound transport	GO:0071705	271	0.032
organophosphate catabolic process	GO:0046434	232	0.032	Worm
neuronal action potential	GO:0019228	54	0.032
regulation of ion transport	GO:0043269	215	0.032	Mouse
forebrain development	GO:0030900	302	0.032	Mouse
myeloid cell apoptotic process	GO:0033028	22	0.031	Mouse
male gonad development	GO:0008584	88	0.031
purine containing compound metabolic process	GO:0072521	311	0.031	Worm
positive regulation of cell development	GO:0010720	237	0.031	Mouse
regulation of cell migration	GO:0030334	219	0.031	Mouse
intracellular protein transport	GO:0006886	204	0.031
dna repair	GO:0006281	107	0.031
myeloid cell differentiation	GO:0030099	233	0.031
pigment cell differentiation	GO:0050931	27	0.031	Mouse
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.031	Worm
regulation of cell cycle phase transition	GO:1901987	77	0.031	Human Mouse
developmental pigmentation	GO:0048066	40	0.030	Mouse
response to nutrient levels	GO:0031667	109	0.030	Mouse
lymphocyte proliferation	GO:0046651	164	0.030	Mouse
regulation of melanocyte differentiation	GO:0045634	7	0.030	Mouse
negative regulation of neuron apoptotic process	GO:0043524	92	0.030
organic cyclic compound catabolic process	GO:1901361	295	0.030	Worm
regulation of protein maturation	GO:1903317	96	0.030	Zebrafish
negative regulation of cell cycle phase transition	GO:1901988	48	0.029	Human Mouse
response to acid chemical	GO:0001101	111	0.029
cell killing	GO:0001906	67	0.029
morphogenesis of a branching epithelium	GO:0061138	193	0.029	Mouse
peptidyl tyrosine modification	GO:0018212	145	0.029
developmental maturation	GO:0021700	193	0.029	Mouse
positive regulation of leukocyte differentiation	GO:1902107	86	0.029
response to extracellular stimulus	GO:0009991	127	0.029	Mouse
cellular response to organonitrogen compound	GO:0071417	145	0.029
negative regulation of immune system process	GO:0002683	209	0.029
establishment or maintenance of cell polarity	GO:0007163	86	0.029
gtp metabolic process	GO:0046039	144	0.029	Worm
striated muscle cell development	GO:0055002	125	0.029	Mouse
erythrocyte differentiation	GO:0030218	88	0.028
response to peptide hormone	GO:0043434	127	0.028
cochlear nucleus development	GO:0021747	4	0.028	Mouse
regulation of protein transport	GO:0051223	163	0.028
skin development	GO:0043588	220	0.028	Mouse
cellular component assembly involved in morphogenesis	GO:0010927	139	0.028
calcium ion homeostasis	GO:0055074	127	0.028	Mouse
engulfment of apoptotic cell	GO:0043652	3	0.028
sequestering of calcium ion	GO:0051208	18	0.028
regulation of developmental pigmentation	GO:0048070	14	0.028	Mouse
cellular carbohydrate metabolic process	GO:0044262	119	0.028
organonitrogen compound biosynthetic process	GO:1901566	192	0.028
wound healing	GO:0042060	157	0.028
protein homooligomerization	GO:0051260	43	0.028	Mouse
cellular response to peptide	GO:1901653	92	0.027
regulation of oxidative stress induced intrinsic apoptotic signaling pathway	GO:1902175	9	0.027	Mouse
regulation of gtp catabolic process	GO:0033124	113	0.027	Worm
positive regulation of kinase activity	GO:0033674	155	0.027
modification of morphology or physiology of other organism	GO:0035821	18	0.027	Human
organelle localization	GO:0051640	179	0.027
response to organic cyclic compound	GO:0014070	198	0.027
regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway	GO:2001267	4	0.027	Mouse
limb morphogenesis	GO:0035108	149	0.027	Mouse
divalent inorganic cation homeostasis	GO:0072507	138	0.027	Mouse
negative regulation of transferase activity	GO:0051348	85	0.027
cation homeostasis	GO:0055080	212	0.026	Mouse
monocarboxylic acid metabolic process	GO:0032787	191	0.026
development of primary male sexual characteristics	GO:0046546	88	0.026
appendage morphogenesis	GO:0035107	149	0.026	Mouse
mitotic cell cycle process	GO:1903047	159	0.026	Human Mouse
development of primary sexual characteristics	GO:0045137	143	0.026
meiotic cell cycle	GO:0051321	122	0.026
negative regulation of b cell apoptotic process	GO:0002903	7	0.026	Mouse
cytokine mediated signaling pathway	GO:0019221	115	0.026
organonitrogen compound catabolic process	GO:1901565	264	0.026	Worm
ribose phosphate metabolic process	GO:0019693	291	0.026	Worm
positive regulation of mapk cascade	GO:0043410	170	0.026
positive regulation of cysteine type endopeptidase activity	GO:2001056	39	0.026	Mouse
embryonic limb morphogenesis	GO:0030326	126	0.026	Mouse
nucleotide catabolic process	GO:0009166	217	0.026	Worm
lymphocyte homeostasis	GO:0002260	64	0.026	Mouse
positive regulation of cell activation	GO:0050867	158	0.026
negative regulation of endoplasmic reticulum calcium ion concentration	GO:0032471	3	0.025	Mouse
gonad development	GO:0008406	141	0.025
regulation of killing of cells of other organism	GO:0051709	4	0.025
regulation of cytokine production	GO:0001817	266	0.025
cellular response to nutrient levels	GO:0031669	64	0.025	Mouse
t cell homeostatic proliferation	GO:0001777	4	0.025	Mouse
peptidyl tyrosine phosphorylation	GO:0018108	143	0.025
circulatory system process	GO:0003013	197	0.025
cell substrate junction assembly	GO:0007044	24	0.025	Mouse
extrinsic apoptotic signaling pathway via death domain receptors	GO:0008625	34	0.025	Mouse
regulation of fibroblast proliferation	GO:0048145	34	0.025	Mouse
regulation of protein stability	GO:0031647	52	0.025	Mouse
response to peptide	GO:1901652	136	0.025
cellular response to cytokine stimulus	GO:0071345	189	0.025
columnar cuboidal epithelial cell differentiation	GO:0002065	82	0.024	Mouse
response to transforming growth factor beta	GO:0071559	88	0.024
positive regulation of nucleotide catabolic process	GO:0030813	88	0.024	Worm
positive regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043280	36	0.024	Mouse
posttranscriptional regulation of gene expression	GO:0010608	155	0.024	Mouse
negative regulation of cell growth	GO:0030308	44	0.024	Mouse
negative regulation of protein maturation	GO:1903318	79	0.024	Zebrafish
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.024
regulation of protein binding	GO:0043393	60	0.024
kidney development	GO:0001822	213	0.024	Mouse
extracellular structure organization	GO:0043062	148	0.024
regulation of cytoplasmic transport	GO:1903649	112	0.024	Mouse
regulation of protein catabolic process	GO:0042176	108	0.024
carbohydrate homeostasis	GO:0033500	128	0.024
limb development	GO:0060173	166	0.024	Mouse
nuclear transport	GO:0051169	139	0.024
epithelial cell development	GO:0002064	159	0.024
gliogenesis	GO:0042063	141	0.024
disruption of cells of other organism involved in symbiotic interaction	GO:0051818	13	0.024
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	62	0.024	Zebrafish Mouse
purine nucleoside catabolic process	GO:0006152	205	0.024	Worm
apoptotic process involved in embryonic digit morphogenesis	GO:1902263	3	0.024	Mouse
nucleoside triphosphate metabolic process	GO:0009141	230	0.024	Worm
nucleocytoplasmic transport	GO:0006913	139	0.023
metal ion homeostasis	GO:0055065	189	0.023	Mouse
ion transmembrane transport	GO:0034220	361	0.023
regulation of lymphocyte differentiation	GO:0045619	107	0.023
innate immune response	GO:0045087	157	0.023
post embryonic organ morphogenesis	GO:0048563	8	0.023	Mouse
connective tissue development	GO:0061448	179	0.023
oocyte axis specification	GO:0007309	2	0.023
establishment of protein localization to organelle	GO:0072594	118	0.023	Mouse
regulation of defense response	GO:0031347	233	0.023
t cell proliferation	GO:0042098	120	0.023	Mouse
skeletal system morphogenesis	GO:0048705	203	0.023
positive regulation of mammary gland involution	GO:1903521	4	0.023	Mouse
calcium ion transport	GO:0006816	159	0.023	Mouse
toxin transport	GO:1901998	38	0.023
positive regulation of protein serine threonine kinase activity	GO:0071902	106	0.023
guanosine containing compound metabolic process	GO:1901068	144	0.023	Worm
leukocyte homeostasis	GO:0001776	79	0.023	Mouse
oogenesis	GO:0048477	56	0.022	Mouse
negative regulation of fibroblast proliferation	GO:0048147	14	0.022	Mouse
placenta development	GO:0001890	140	0.022
cellular response to starvation	GO:0009267	57	0.022	Mouse
meiotic nuclear division	GO:0007126	115	0.022
regulation of intracellular protein transport	GO:0033157	82	0.022
regulation of secretion by cell	GO:1903530	249	0.022
axon guidance	GO:0007411	141	0.022
nuclear division	GO:0000280	158	0.022
morphogenesis of a branching structure	GO:0001763	203	0.022	Mouse
lymphocyte differentiation	GO:0030098	242	0.022	Mouse
locomotory behavior	GO:0007626	195	0.022
establishment or maintenance of microtubule cytoskeleton polarity	GO:0030951	1	0.022
regulation of proteasomal protein catabolic process	GO:0061136	46	0.022
amide transport	GO:0042886	138	0.022
positive regulation of lymphocyte activation	GO:0051251	140	0.022
proteasomal protein catabolic process	GO:0010498	98	0.022
response to starvation	GO:0042594	65	0.022	Mouse
positive regulation of secretion	GO:0051047	130	0.022
heterocycle catabolic process	GO:0046700	280	0.022	Worm
negative regulation of intrinsic apoptotic signaling pathway	GO:2001243	34	0.022	Human Zebrafish
cellular response to external stimulus	GO:0071496	88	0.022	Mouse
immune response regulating signaling pathway	GO:0002764	125	0.022
intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator	GO:0042771	24	0.021
pallium development	GO:0021543	120	0.021	Mouse
multi multicellular organism process	GO:0044706	109	0.021
regulation of mitochondrial membrane permeability involved in apoptotic process	GO:1902108	14	0.021	Mouse
viral life cycle	GO:0019058	36	0.021	Mouse
carbohydrate metabolic process	GO:0005975	230	0.021
development of primary female sexual characteristics	GO:0046545	73	0.021
defense response to other organism	GO:0098542	197	0.021
modification of morphology or physiology of other organism involved in symbiotic interaction	GO:0051817	16	0.021	Human
activation of cysteine type endopeptidase activity involved in apoptotic process by cytochrome c	GO:0008635	4	0.021	Mouse

Bcl2l1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
disease of cellular proliferation	DOID:14566	0.120
cancer	DOID:162	0.120
organ system cancer	DOID:0050686	0.068
disease of anatomical entity	DOID:7	0.037
immune system disease	DOID:2914	0.037
immune system cancer	DOID:0060083	0.029
hematologic cancer	DOID:2531	0.027
musculoskeletal system disease	DOID:17	0.026

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