Mus musculus

5 known processes

Dhfr

dihydrofolate reductase

(Aliases: 8430436I03Rik,AI662710,AW555094,AA607882)

Dhfr biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cellular response to dna damage stimulusGO:00069742070.549
dna metabolic processGO:00062593030.529
dna repairGO:00062811070.331
dna replicationGO:0006260520.247
double strand break repairGO:0006302480.169
cellular nitrogen compound catabolic processGO:00442702800.152
meiosis iGO:0007127600.149
nucleoside metabolic processGO:00091162460.139
cellular amino acid metabolic processGO:00065201030.118
organic cyclic compound catabolic processGO:19013612950.107
nucleobase containing small molecule metabolic processGO:00550863520.100
aromatic compound catabolic processGO:00194392860.099
dna dependent dna replicationGO:0006261240.093
intrinsic apoptotic signaling pathwayGO:00971931320.090
purine containing compound metabolic processGO:00725213110.085
meiotic nuclear divisionGO:00071261150.080
heterocycle catabolic processGO:00467002800.077
apoptotic signaling pathwayGO:00971903060.074
cellular macromolecule catabolic processGO:00442652060.071
dna recombinationGO:0006310920.062
glycosyl compound metabolic processGO:19016572460.058
nucleoside monophosphate metabolic processGO:0009123850.056
purine nucleoside triphosphate metabolic processGO:00091442260.052
purine ribonucleotide metabolic processGO:00091502900.051
meiotic cell cycle processGO:1903046770.051
ribonucleoside metabolic processGO:00091192450.049
purine nucleotide metabolic processGO:00061633020.047
purine ribonucleoside triphosphate metabolic processGO:00092052200.046
mitotic chromosome condensationGO:000707610.045
mitotic cell cycleGO:00002781950.045
oxidation reduction processGO:00551143420.044
nucleotide metabolic processGO:00091173320.043
purine nucleoside metabolic processGO:00422782410.042
regulation of cell cycleGO:00517262810.042
dna dependent dna replication maintenance of fidelityGO:004500530.041
dna endoreduplicationGO:004202340.041
b cell activationGO:00421131610.040
amine metabolic processGO:0009308450.040
methylationGO:00322591340.037
cellular ketone metabolic processGO:0042180840.037
lipid biosynthetic processGO:00086101790.036
purine ribonucleoside metabolic processGO:00461282410.036
mitochondrion organizationGO:00070051340.036
organonitrogen compound catabolic processGO:19015652640.035
regulation of cellular ketone metabolic processGO:0010565660.035
purine ribonucleoside triphosphate catabolic processGO:00092071990.035
myeloid cell differentiationGO:00300992330.034
nucleoside triphosphate catabolic processGO:00091432050.034
female meiosis chromosome segregationGO:001632110.034
myeloid cell homeostasisGO:00022621140.034
alpha amino acid metabolic processGO:1901605590.033
nucleoside triphosphate metabolic processGO:00091412300.033
carboxylic acid biosynthetic processGO:0046394860.033
cellular amine metabolic processGO:0044106440.033
nucleoside phosphate catabolic processGO:19012922220.033
ribonucleotide catabolic processGO:00092612080.032
nucleic acid phosphodiester bond hydrolysisGO:0090305490.032
cellular response to oxidative stressGO:0034599760.032
negative regulation of cell cycleGO:00457861230.032
regulation of transferase activityGO:00513382630.031
purine ribonucleotide catabolic processGO:00091542080.031
cellular response to lipidGO:00713961450.031
reciprocal meiotic recombinationGO:0007131160.031
nucleoside catabolic processGO:00091642060.030
positive regulation of cellular amino acid metabolic processGO:004576430.030
negative regulation of immune system processGO:00026832090.030
organonitrogen compound biosynthetic processGO:19015661920.029
lymphocyte mediated immunityGO:00024491390.029
nucleoside phosphate metabolic processGO:00067533380.028
regulation of cellular amino acid metabolic processGO:000652150.028
small molecule biosynthetic processGO:00442831320.028
intrinsic apoptotic signaling pathway in response to dna damageGO:0008630570.028
nucleotide catabolic processGO:00091662170.027
regulation of cellular amine metabolic processGO:0033238200.027
positive regulation of cellular amine metabolic processGO:003324050.026
purine ribonucleoside monophosphate metabolic processGO:0009167800.026
homeostasis of number of cellsGO:00488722100.026
chromosome segregationGO:0007059480.026
microtubule cytoskeleton organizationGO:00002261570.026
meiotic cell cycleGO:00513211220.026
cell divisionGO:00513011200.025
organophosphate catabolic processGO:00464342320.025
cellular lipid metabolic processGO:00442553230.025
ribonucleoside catabolic processGO:00424542060.025
nuclear dna replicationGO:003326030.025
ribonucleoside triphosphate metabolic processGO:00091992200.025
spermatogenesisGO:00072832840.024
organelle fissionGO:00482851700.024
development of primary sexual characteristicsGO:00451371430.024
positive regulation of cell deathGO:00109422240.024
organelle assemblyGO:00709251770.024
germ cell developmentGO:00072811850.024
response to organic cyclic compoundGO:00140701980.023
positive regulation of apoptotic processGO:00430652170.023
dna catabolic process endonucleolyticGO:0000737150.023
double strand break repair via homologous recombinationGO:0000724210.023
purine nucleoside catabolic processGO:00061522050.023
organic acid biosynthetic processGO:0016053860.023
dna catabolic processGO:0006308190.023
glycosyl compound catabolic processGO:19016582060.023
production of molecular mediator of immune responseGO:00024401030.022
ribose phosphate metabolic processGO:00196932910.022
synapsisGO:0007129340.022
purine nucleoside monophosphate metabolic processGO:0009126810.022
regulation of cell cycle processGO:00105641600.022
purine ribonucleoside catabolic processGO:00461302050.021
mitotic cell cycle processGO:19030471590.021
dna conformation changeGO:0071103370.021
response to radiationGO:00093141650.021
cell cycle checkpointGO:0000075470.021
nitrogen compound transportGO:00717052710.021
somatic diversification of immune receptors via somatic mutationGO:000256680.020
microtubule based processGO:00070172360.020
macromolecule methylationGO:00434141200.020
nucleoside monophosphate catabolic processGO:0009125590.020
protein maturationGO:00516041760.020
leukocyte differentiationGO:00025213420.020
regulation of lipid metabolic processGO:00192161180.020
small molecule catabolic processGO:0044282710.020
negative regulation of cellular component organizationGO:00511291940.020
male gonad developmentGO:0008584880.020
macromolecule catabolic processGO:00090572810.020
response to extracellular stimulusGO:00099911270.020
heterochromatin organizationGO:007082840.019
regulation of chromosome organizationGO:0033044830.019
epithelial tube morphogenesisGO:00605623030.019
regulation of hydrolase activityGO:00513362460.019
cellular homeostasisGO:00197252400.019
regulation of lymphocyte activationGO:00512492400.018
response to lipopolysaccharideGO:00324961280.018
positive regulation of programmed cell deathGO:00430682180.018
response to oxidative stressGO:00069791230.018
positive regulation of histone h3 k9 methylationGO:005157440.018
endocytosisGO:00068971680.018
sensory perceptionGO:00076002450.018
regulation of organelle organizationGO:00330432890.018
ribonucleotide metabolic processGO:00092592910.018
cellular response to organonitrogen compoundGO:00714171450.018
cellular response to molecule of bacterial originGO:0071219830.018
membrane organizationGO:00610242450.018
response to organonitrogen compoundGO:00102432460.017
ribonucleoside monophosphate metabolic processGO:0009161800.017
dna packagingGO:0006323300.017
regulation of apoptotic signaling pathwayGO:20012331970.017
positive regulation of protein modification processGO:00314012990.017
protein oligomerizationGO:0051259670.017
male gamete generationGO:00482322850.017
anion transportGO:00068201770.017
skin developmentGO:00435882200.017
carbohydrate derivative catabolic processGO:19011362310.017
cilium morphogenesisGO:00602711020.017
regulation of cell activationGO:00508652890.016
gland developmentGO:00487323300.016
negative regulation of dna replicationGO:000815640.016
somatic diversification of immunoglobulinsGO:0016445430.016
gonad developmentGO:00084061410.016
somatic hypermutation of immunoglobulin genesGO:001644670.016
protein ubiquitinationGO:00165671710.016
regulation of cell cycle phase transitionGO:1901987770.016
small gtpase mediated signal transductionGO:0007264970.015
cilium assemblyGO:0042384810.015
response to light stimulusGO:00094161350.015
somatic diversification of immune receptorsGO:0002200530.015
multicellular organism growthGO:00352641610.015
digestive tract developmentGO:00485651900.015
cytoplasmic transportGO:00164822340.015
digestive system developmentGO:00551232000.015
cellular response to lipopolysaccharideGO:0071222770.015
negative regulation of dna recombinationGO:0045910130.015
positive regulation of kinase activityGO:00336741550.015
ras protein signal transductionGO:0007265770.015
purine nucleoside triphosphate catabolic processGO:00091462030.015
somatic diversification of immune receptors via germline recombination within a single locusGO:0002562510.015
regulation of cell divisionGO:0051302760.014
digestive tract morphogenesisGO:00485461470.014
reactive oxygen species metabolic processGO:0072593840.014
somatic cell dna recombinationGO:0016444510.014
somatic recombination of immunoglobulin gene segmentsGO:0016447420.014
double strand break repair via nonhomologous end joiningGO:0006303100.014
regulation of protein kinase activityGO:00458592320.014
purine containing compound catabolic processGO:00725232130.014
positive regulation of hydrolase activityGO:00513451480.014
response to nutrient levelsGO:00316671090.014
peptidyl lysine modificationGO:0018205770.014
locomotory behaviorGO:00076261950.014
extrinsic apoptotic signaling pathwayGO:00971911260.014
cell fate commitmentGO:00451652100.014
protein localization to organelleGO:00333651850.014
cellular response to biotic stimulusGO:0071216920.013
regulation of cellular catabolic processGO:00313292420.013
immunoglobulin productionGO:0002377730.013
immune effector processGO:00022523210.013
negative regulation of lymphocyte activationGO:0051250910.013
response to molecule of bacterial originGO:00022371430.013
carbohydrate homeostasisGO:00335001280.013
regulation of mitotic cell cycleGO:00073461260.013
adaptive immune responseGO:00022501550.013
nuclear divisionGO:00002801580.013
protein catabolic processGO:00301632210.013
immunoglobulin mediated immune responseGO:0016064690.013
cell cycle g1 s phase transitionGO:0044843570.013
negative regulation of apoptotic signaling pathwayGO:20012341040.013
cellular component assembly involved in morphogenesisGO:00109271390.013
lateral inhibitionGO:004633110.013
chromosome organization involved in meiosisGO:0070192390.013
cellular response to hormone stimulusGO:00328701500.013
dna modificationGO:0006304500.013
monocarboxylic acid metabolic processGO:00327871910.013
alpha amino acid biosynthetic processGO:1901607150.013
protein tetramerizationGO:0051262230.012
nuclear transportGO:00511691390.012
cellular protein catabolic processGO:00442571550.012
cellular chemical homeostasisGO:00550822150.012
female gamete generationGO:0007292740.012
purine nucleotide catabolic processGO:00061952110.012
male meiosis iGO:0007141160.012
female meiotic divisionGO:0007143210.012
atp metabolic processGO:0046034750.012
leukocyte mediated immunityGO:00024431740.012
cell activation involved in immune responseGO:00022631260.012
cellular response to cytokine stimulusGO:00713451890.012
peptidyl amino acid modificationGO:00181933360.012
protein methylationGO:0006479810.012
negative regulation of transferase activityGO:0051348850.011
dna alkylationGO:0006305430.011
rna catabolic processGO:0006401290.011
cellular modified amino acid metabolic processGO:0006575630.011
nucleoside phosphate biosynthetic processGO:1901293790.011
cation transportGO:00068123990.011
cellular response to organic cyclic compoundGO:0071407870.011
development of primary male sexual characteristicsGO:0046546880.011
male sex differentiationGO:00466611090.011
carbohydrate metabolic processGO:00059752300.011
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:00024601450.011
regulation of b cell activationGO:0050864810.011
positive regulation of cell developmentGO:00107202370.011
mrna metabolic processGO:0016071840.011
mitotic recombinationGO:000631230.011
wnt signaling pathwayGO:00160551880.011
morphogenesis of a branching epitheliumGO:00611381930.011
response to hydrogen peroxideGO:0042542320.011
lung developmentGO:00303241640.011
covalent chromatin modificationGO:00165691630.011
proteolysis involved in cellular protein catabolic processGO:00516031470.011
ubiquitin dependent protein catabolic processGO:00065111290.011
negative regulation of phagocytosisGO:005076540.011
glucose homeostasisGO:00425931280.011
ribonucleoside triphosphate catabolic processGO:00092031990.011
response to inorganic substanceGO:0010035960.010
amide transportGO:00428861380.010
rho protein signal transductionGO:0007266320.010
response to acid chemicalGO:00011011110.010
respiratory system developmentGO:00605411900.010
lymphocyte differentiationGO:00300982420.010
negative regulation of mitotic cell cycleGO:0045930580.010
regulation of nucleotide metabolic processGO:00061401690.010
histone modificationGO:00165701590.010
innate immune responseGO:00450871570.010
regulation of mapk cascadeGO:00434082480.010
cell type specific apoptotic processGO:00972852680.010
folic acid containing compound metabolic processGO:000676030.010
establishment of organelle localizationGO:00516561220.010
cellular response to abiotic stimulusGO:0071214560.010
cellular carbohydrate metabolic processGO:00442621190.010
isotype switchingGO:0045190360.010
leukocyte proliferationGO:00706611720.010

Dhfr disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
immune system diseaseDOID:291400.024
disease of anatomical entityDOID:700.024
bone marrow diseaseDOID:496100.018
congenital hypoplastic anemiaDOID:134200.018
aplastic anemiaDOID:1244900.018
hematopoietic system diseaseDOID:7400.018
anemiaDOID:235500.018
fanconi s anemiaDOID:1363600.018
disease of cellular proliferationDOID:1456600.015
organ system cancerDOID:005068600.012
cancerDOID:16200.012
nervous system diseaseDOID:86300.011