Mus musculus

445 known processes

Sirt1

sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)

(Aliases: SIR2L1,Sir2alpha,AA673258,Sir2,Sir2a,MGC150273)

Sirt1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cellular response to dna damage stimulusGO:00069742070.953
rhythmic processGO:00485111740.951
positive regulation of apoptotic processGO:00430652170.946
covalent chromatin modificationGO:00165691630.943
hexose metabolic processGO:0019318980.935
protein localization to organelleGO:00333651850.930
Human
chromatin organizationGO:00063252060.929
histone modificationGO:00165701590.925
regulation of intracellular steroid hormone receptor signaling pathwayGO:0033143180.910
Human
regulation of cell cycleGO:00517262810.895
Human
chromatin modificationGO:00165681870.893
regulation of fatty acid oxidationGO:0046320100.886
response to radiationGO:00093141650.886
gluconeogenesisGO:0006094390.876
myeloid cell differentiationGO:00300992330.875
apoptotic signaling pathwayGO:00971903060.874
gland developmentGO:00487323300.865
protein modification by small protein conjugationGO:00324461870.859
Human
positive regulation of apoptotic signaling pathwayGO:2001235950.837
monosaccharide metabolic processGO:00059961060.830
modification dependent macromolecule catabolic processGO:00436321330.826
Human
signal transduction by p53 class mediatorGO:0072331510.817
negative regulation of molecular functionGO:00440922580.810
Human
positive regulation of fatty acid oxidationGO:004632140.804
negative regulation of transferase activityGO:0051348850.793
Human
regulation of gluconeogenesisGO:0006111300.792
dna metabolic processGO:00062593030.786
regulation of fatty acid metabolic processGO:0019217280.776
negative regulation of protein modification processGO:00314001630.776
Human
regulation of cell cycle processGO:00105641600.765
cellular carbohydrate metabolic processGO:00442621190.750
negative regulation of cell proliferationGO:00082852960.729
cellular ketone metabolic processGO:0042180840.714
multicellular organism growthGO:00352641610.705
cellular response to radiationGO:0071478280.700
response to hypoxiaGO:0001666580.685
Human
histone acetylationGO:0016573410.676
Worm Fly
branching morphogenesis of an epithelial tubeGO:00487541590.657
regulation of response to dna damage stimulusGO:2001020340.655
modification dependent protein catabolic processGO:00199411330.654
Human
cell cycle checkpointGO:0000075470.651
positive regulation of programmed cell deathGO:00430682180.647
fibroblast proliferationGO:0048144350.643
negative regulation of cell cycleGO:00457861230.620
response to light stimulusGO:00094161350.617
regulation of lipid metabolic processGO:00192161180.615
intracellular receptor signaling pathwayGO:0030522740.613
cell type specific apoptotic processGO:00972852680.609
male gamete generationGO:00482322850.609
generation of precursor metabolites and energyGO:00060911030.607
intrinsic apoptotic signaling pathwayGO:00971931320.603
erythrocyte differentiationGO:0030218880.599
negative regulation of phosphorus metabolic processGO:00105631840.595
regulation of cell cycle checkpointGO:190197690.584
hexose biosynthetic processGO:0019319390.578
maintenance of locationGO:0051235890.569
striated muscle tissue developmentGO:00147062930.568
organelle fissionGO:00482851700.568
oxidation reduction processGO:00551143420.568
intrinsic apoptotic signaling pathway in response to dna damageGO:0008630570.566
cellular protein catabolic processGO:00442571550.566
Human
response to decreased oxygen levelsGO:0036293590.557
Human
b cell activationGO:00421131610.557
circadian rhythmGO:00076231140.557
regulation of carbohydrate metabolic processGO:0006109750.557
regulation of sequence specific dna binding transcription factor activityGO:00510901060.553
Human
cellular calcium ion homeostasisGO:00068741190.552
cellular response to peptide hormone stimulusGO:0071375920.550
Human
regulation of circadian rhythmGO:0042752580.540
carbohydrate biosynthetic processGO:0016051740.529
proteolysis involved in cellular protein catabolic processGO:00516031470.525
Human
response to extracellular stimulusGO:00099911270.518
response to organonitrogen compoundGO:00102432460.511
lipid storageGO:0019915360.506
positive regulation of sequence specific dna binding transcription factor activityGO:0051091680.489
carbohydrate metabolic processGO:00059752300.484
proteasome mediated ubiquitin dependent protein catabolic processGO:0043161880.474
Human
negative regulation of protein metabolic processGO:00512482820.473
Human
cellular lipid metabolic processGO:00442553230.458
steroid metabolic processGO:00082021190.435
negative regulation of phosphate metabolic processGO:00459361840.431
regulation of cell cycle phase transitionGO:1901987770.429
response to peptide hormoneGO:00434341270.417
monocarboxylic acid metabolic processGO:00327871910.406
regulation of hormone levelsGO:00108172110.404
peptidyl amino acid modificationGO:00181933360.403
Human Worm Fly
protein modification by small protein conjugation or removalGO:00706472070.398
Human
protein deacetylationGO:0006476320.395
monosaccharide biosynthetic processGO:0046364440.388
negative regulation of dna replicationGO:000815640.383
negative regulation of cell cycle phase transitionGO:1901988480.379
intracellular steroid hormone receptor signaling pathwayGO:0030518290.379
Human
mitotic cell cycleGO:00002781950.378
Human
regulation of dna damage checkpointGO:200000130.377
lipid modificationGO:0030258650.374
response to organic cyclic compoundGO:00140701980.374
Human
protein localization to nucleusGO:00345041210.369
Human
dna damage checkpointGO:0000077260.369
protein ubiquitinationGO:00165671710.366
Human
regulation of myeloid cell differentiationGO:0045637960.362
regulation of peptidase activityGO:0052547960.359
Human
muscle cell differentiationGO:00426922610.352
maternal process involved in female pregnancyGO:0060135320.352
negative regulation of cellular protein metabolic processGO:00322692470.350
Human
development of primary sexual characteristicsGO:00451371430.346
spermatogenesisGO:00072832840.340
skeletal muscle cell differentiationGO:0035914660.337
male meiosisGO:0007140370.335
macromolecule catabolic processGO:00090572810.320
Human
myeloid leukocyte differentiationGO:00025731190.319
response to nutrient levelsGO:00316671090.318
regulation of leukocyte differentiationGO:19021051590.317
positive regulation of endopeptidase activityGO:0010950430.317
Human
regulation of cellular ketone metabolic processGO:0010565660.316
positive regulation of gluconeogenesisGO:0045722110.312
regulation of mitotic cell cycle phase transitionGO:1901990730.309
sensory perceptionGO:00076002450.309
circadian sleep wake cycleGO:004274550.305
negative regulation of neuron deathGO:1901215980.305
regulation of chromosome organizationGO:0033044830.302
Human Fly
lipid oxidationGO:0034440290.300
negative regulation of intracellular signal transductionGO:19025321670.293
protein processingGO:00164851630.287
homeostasis of number of cellsGO:00488722100.285
regulation of cellular amine metabolic processGO:0033238200.284
negative regulation of phosphorylationGO:00423261660.280
regulation of proteasomal ubiquitin dependent protein catabolic processGO:0032434400.277
positive regulation of lipid metabolic processGO:0045834400.273
regulation of glucose metabolic processGO:0010906600.269
regulation of secretion by cellGO:19035302490.269
regulation of carbohydrate biosynthetic processGO:0043255400.267
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781940.266
response to temperature stimulusGO:0009266550.266
protein catabolic processGO:00301632210.265
Human
columnar cuboidal epithelial cell differentiationGO:0002065820.262
regulation of lipid catabolic processGO:0050994150.251
epithelial cell proliferationGO:00506731740.251
regulation of organelle organizationGO:00330432890.250
Human Fly
negative regulation of mitotic cell cycle phase transitionGO:1901991450.250
regulation of ion transportGO:00432692150.247
establishment of protein localization to organelleGO:00725941180.244
Human
dna integrity checkpointGO:0031570280.239
leukocyte differentiationGO:00025213420.237
lymphocyte differentiationGO:00300982420.237
epithelial cell developmentGO:00020641590.234
regulation of fibroblast proliferationGO:0048145340.231
muscle tissue developmentGO:00605373080.227
regulation of myeloid leukocyte differentiationGO:0002761580.226
ossificationGO:00015032160.225
eye photoreceptor cell differentiationGO:0001754410.223
negative regulation of mitotic cell cycleGO:0045930580.221
cation transportGO:00068123990.218
internal protein amino acid acetylationGO:0006475420.215
Worm Fly
fat cell differentiationGO:00454441600.213
respiratory tube developmentGO:00303231670.212
glucose homeostasisGO:00425931280.211
cell growthGO:00160491300.211
Human
purine nucleoside biosynthetic processGO:0042451190.209
t cell differentiationGO:00302171740.208
anatomical structure homeostasisGO:00602491450.198
regulation of cysteine type endopeptidase activityGO:2000116650.198
Human
positive regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043280360.197
Human
positive regulation of cysteine type endopeptidase activityGO:2001056390.197
Human
cellular response to inorganic substanceGO:0071241370.197
protein maturationGO:00516041760.196
positive regulation of proteolysisGO:0045862850.195
Human
skeletal muscle organ developmentGO:00605381630.195
nucleoside monophosphate metabolic processGO:0009123850.195
response to peptideGO:19016521360.191
placenta developmentGO:00018901400.190
gene silencingGO:0016458380.190
Human Fly
negative regulation of cellular response to insulin stimulusGO:1900077160.190
amine metabolic processGO:0009308450.189
fatty acid oxidationGO:0019395280.186
protein autophosphorylationGO:0046777610.185
cellular response to abiotic stimulusGO:0071214560.185
positive regulation of carbohydrate metabolic processGO:0045913300.181
nuclear divisionGO:00002801580.181
regulation of apoptotic signaling pathwayGO:20012331970.180
positive regulation of cell deathGO:00109422240.180
somite developmentGO:0061053810.180
mrna processingGO:0006397630.177
circadian regulation of gene expressionGO:0032922480.177
peptide transportGO:00158331330.176
negative regulation of sequence specific dna binding transcription factor activityGO:0043433400.174
Human
t cell activationGO:00421102890.172
negative regulation of proteolysisGO:0045861740.171
carbohydrate derivative biosynthetic processGO:19011371830.171
gonad developmentGO:00084061410.171
multicellular organismal homeostasisGO:00488711640.170
positive regulation of protein modification processGO:00314012990.168
regulation of transferase activityGO:00513382630.167
cellular chemical homeostasisGO:00550822150.166
cellular homeostasisGO:00197252400.164
cellular amine metabolic processGO:0044106440.163
regulation of cellular response to stressGO:00801351590.161
intracellular protein transportGO:00068862040.161
Human
blastocyst developmentGO:0001824800.160
response to glucagonGO:003376230.157
cellular response to lipidGO:00713961450.157
Human
protein acylationGO:0043543640.156
Human Worm Fly
dna damage response signal transduction by p53 class mediatorGO:0030330190.156
Human
leukocyte apoptotic processGO:0071887710.155
regulation of nitrogen cycle metabolic processGO:190331410.155
cellular amino acid metabolic processGO:00065201030.155
autophagyGO:0006914450.152
nuclear transportGO:00511691390.152
Human
meiotic cell cycleGO:00513211220.149
response to starvationGO:0042594650.149
glucose metabolic processGO:0006006920.146
regulation of secretionGO:00510462740.146
positive regulation of cellular amine metabolic processGO:003324050.145
response to inorganic substanceGO:0010035960.144
Human
neuron apoptotic processGO:00514021420.144
response to uvGO:0009411440.143
osteoclast differentiationGO:0030316620.142
purine nucleotide metabolic processGO:00061633020.142
organ growthGO:00352651170.140
cellular ion homeostasisGO:00068731650.137
glycosyl compound metabolic processGO:19016572460.137
positive regulation of glucose metabolic processGO:0010907210.137
extrinsic apoptotic signaling pathwayGO:00971911260.135
ubiquitin dependent protein catabolic processGO:00065111290.135
Human
regulation of steroid biosynthetic processGO:0050810260.135
response to alkaloidGO:0043279340.134
positive regulation of cellular carbohydrate metabolic processGO:0010676290.132
mitotic cell cycle processGO:19030471590.130
regulation of protein kinase activityGO:00458592320.130
positive regulation of growthGO:00459271040.127
organonitrogen compound biosynthetic processGO:19015661920.127
multi multicellular organism processGO:00447061090.125
ribonucleoprotein complex subunit organizationGO:0071826280.125
ion transmembrane transportGO:00342203610.124
regulation of cellular catabolic processGO:00313292420.123
embryonic placenta developmentGO:0001892980.123
regulation of lipid biosynthetic processGO:0046890540.123
lactationGO:0007595250.123
molting cycleGO:0042303900.121
regulation of glucocorticoid secretionGO:200084950.121
mitotic cell cycle checkpointGO:0007093310.120
neuron deathGO:00709971540.120
regulation of cellular amino acid metabolic processGO:000652150.119
meiotic nuclear divisionGO:00071261150.119
cellular response to acid chemicalGO:0071229680.118
cellular magnesium ion homeostasisGO:001096130.117
jak stat cascadeGO:0007259420.117
positive regulation of fatty acid metabolic processGO:004592380.116
response to oxidative stressGO:00069791230.115
Human
cellular response to oxidative stressGO:0034599760.115
Human
myotube differentiationGO:00149021050.115
organic anion transportGO:00157111370.114
blood circulationGO:00080151950.114
internal peptidyl lysine acetylationGO:0018393420.114
Worm Fly
positive regulation of fibroblast proliferationGO:0048146200.113
proteasomal protein catabolic processGO:0010498980.112
Human
lipid biosynthetic processGO:00086101790.112
morphogenesis of a branching structureGO:00017632030.112
single organism nuclear importGO:1902593950.112
Human
cholesterol storageGO:001087840.111
male meiosis iGO:0007141160.109
negative regulation of cell sizeGO:004579230.109
regulation of mesenchymal cell proliferationGO:0010464370.109
purine containing compound biosynthetic processGO:0072522700.107
regulation of epithelial cell proliferationGO:00506781410.107
regulation of defense responseGO:00313472330.106
protein targetingGO:00066051430.106
Human
eye photoreceptor cell developmentGO:0042462310.105
developmental maturationGO:00217001930.104
negative regulation of protein processingGO:0010955790.104
positive regulation of cellular respirationGO:190185730.103
rna polymerase ii transcriptional preinitiation complex assemblyGO:005112330.103
spliceosomal complex disassemblyGO:000039010.102
regulation of protein catabolic processGO:00421761080.101
cholesterol homeostasisGO:0042632440.101
negative regulation of lipid metabolic processGO:0045833300.100
amide transportGO:00428861380.099
cell agingGO:0007569350.099
Human
positive regulation of cell cycleGO:0045787920.098
monocarboxylic acid transportGO:0015718440.097
response to tumor necrosis factorGO:0034612260.097
Human
peptidyl lysine modificationGO:0018205770.096
Human Worm Fly
posttranscriptional regulation of gene expressionGO:00106081550.095
endocrine system developmentGO:0035270980.095
organic acid transportGO:00158491010.094
female gamete generationGO:0007292740.094
cellular response to hormone stimulusGO:00328701500.093
Human
regulation of hormone secretionGO:0046883880.093
cellular response to nutrient levelsGO:0031669640.091
nucleoside phosphate metabolic processGO:00067533380.090
dna biosynthetic processGO:0071897220.089
cell maturationGO:00484691270.089
response to oxygen levelsGO:0070482620.088
Human
regulation of homeostatic processGO:00328441820.088
negative regulation of transcription involved in g1 s transition of mitotic cell cycleGO:007193010.087
purine containing compound metabolic processGO:00725213110.087
positive regulation of phagocytosis engulfmentGO:006010030.086
ribonucleoside monophosphate metabolic processGO:0009161800.086
negative regulation of kinase activityGO:0033673810.086
Human
positive regulation of cell developmentGO:00107202370.086
energy derivation by oxidation of organic compoundsGO:0015980770.085
negative regulation of insulin receptor signaling pathwayGO:0046627140.085
positive regulation of intrinsic apoptotic signaling pathwayGO:2001244250.084
response to estrogenGO:0043627240.084
regulation of vasculature developmentGO:1901342880.084
regulation of hydrolase activityGO:00513362460.083
Human
regulation of kinase activityGO:00435492490.083
digestionGO:0007586400.083
positive regulation of transferase activityGO:00513471670.083
negative regulation of neuron apoptotic processGO:0043524920.083
cellular macromolecule catabolic processGO:00442652060.082
Human
regulation of feeding behaviorGO:006025930.082
Fly
protein sumoylationGO:0016925140.081
regulation of cellular response to insulin stimulusGO:1900076300.081
Human
regulation of fat cell differentiationGO:0045598810.081
purine nucleoside monophosphate metabolic processGO:0009126810.080
cell adhesionGO:00071553290.080
cytoplasmic transportGO:00164822340.079
Human
regulation of cell activationGO:00508652890.079
chromatin silencingGO:0006342150.079
Human Fly
forebrain developmentGO:00309003020.079
hormone secretionGO:00468791280.078
lung developmentGO:00303241640.078
bone morphogenesisGO:0060349780.078
lipid localizationGO:00108761260.078
negative regulation of circadian rhythmGO:004275480.077
positive regulation of apoptotic process involved in mammary gland involutionGO:006005840.077
regulation of protein stabilityGO:0031647520.076
cellular response to decreased oxygen levelsGO:0036294180.076
Human
response to acid chemicalGO:00011011110.075
positive regulation of kinase activityGO:00336741550.075
protein import into nucleusGO:0006606950.075
Human
divalent inorganic cation transportGO:00725111780.074
cellular metal ion homeostasisGO:00068751510.074
regulation of intracellular transportGO:00323861590.073
Human
regionalizationGO:00030023370.073
regulation of telomerase activityGO:005197210.073
epithelial tube morphogenesisGO:00605623030.073
myeloid cell homeostasisGO:00022621140.072
positive regulation of defense responseGO:00313491240.072
mapk cascadeGO:00001652810.071
nitrogen compound transportGO:00717052710.070
positive regulation of peptidase activityGO:0010952490.070
Human
response to coldGO:0009409190.070
g1 s transition of mitotic cell cycleGO:0000082570.069
purine ribonucleotide metabolic processGO:00091502900.069
cellular response to light stimulusGO:0071482190.069
purine nucleotide biosynthetic processGO:0006164650.069
axis elongationGO:0003401300.068
atp metabolic processGO:0046034750.068
circulatory system processGO:00030131970.068
response to amino acidGO:0043200370.067
ear developmentGO:00435832000.067
negative regulation of protein maturationGO:1903318790.066
response to drugGO:0042493750.066
regulation of mitotic cell cycleGO:00073461260.066
Human
cell divisionGO:00513011200.066
neural precursor cell proliferationGO:00613511210.065
regulation of leukocyte apoptotic processGO:2000106560.065
protein importGO:00170381010.065
Human
macroautophagyGO:0016236210.065
organ regenerationGO:003110020.065
regulation of cell migrationGO:00303342190.065
nucleoside metabolic processGO:00091162460.064
regulation of transcription involved in g1 s transition of mitotic cell cycleGO:000008330.064
organophosphate biosynthetic processGO:00904071220.064
regulation of calcium ion transport into cytosolGO:0010522310.063
axonogenesisGO:00074092740.063
vitamin d biosynthetic processGO:004236830.063
n terminal protein amino acid modificationGO:003136560.062
fatty acid metabolic processGO:00066311210.062
response to ionizing radiationGO:0010212420.062
calcium ion transport into cytosolGO:0060402480.062
regulation of transmembrane transportGO:00347621280.060
regulation of nuclear divisionGO:0051783560.060
galactose metabolic processGO:000601240.060
regulation of protein processingGO:0070613960.060
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043281620.058
Human
multicellular organismal agingGO:0010259240.058
Worm Fly
l glutamate uptake involved in synaptic transmissionGO:005193530.058
positive regulation of endothelial cell proliferationGO:0001938170.058
prostate gland morphogenesisGO:0060512320.058
regulation of cell divisionGO:0051302760.057
positive regulation of mitotic cell cycleGO:0045931410.057
calcium ion transportGO:00068161590.057
negative regulation of cell cycle processGO:0010948690.057
activation of cysteine type endopeptidase activityGO:0097202270.056
negative regulation of tor signalingGO:0032007130.056
nucleocytoplasmic transportGO:00069131390.056
Human
regulation of neuron apoptotic processGO:00435231220.056
intrinsic apoptotic signaling pathway in response to oxidative stressGO:0008631190.056
Human
androgen receptor signaling pathwayGO:003052180.056
Human
posttranscriptional gene silencingGO:0016441100.055
regulation of proteolysisGO:00301621640.055
Human
germline stem cell asymmetric divisionGO:009872820.055
regulation of lymphocyte activationGO:00512492400.055
regulation of ion transmembrane transportGO:00347651190.054
histone h3 deacetylationGO:007093280.054
positive regulation of organelle organizationGO:00106381280.053
Human
fatty acid transportGO:0015908280.053
response to testosteroneGO:003357430.053
Human
positive regulation of intracellular protein transportGO:0090316420.053
tissue homeostasisGO:00018941150.052
carbohydrate homeostasisGO:00335001280.051
negative regulation of epithelial cell proliferationGO:0050680640.051
purine ribonucleoside monophosphate metabolic processGO:0009167800.051
blood vessel morphogenesisGO:00485142850.051
Human
b cell apoptotic processGO:0001783190.051
purine ribonucleoside biosynthetic processGO:0046129190.050
positive regulation of hormone secretionGO:0046887380.050
regulation of lymphocyte proliferationGO:00506701170.050
learning or memoryGO:00076111480.050
cell cycle g1 s phase transitionGO:0044843570.049
negative regulation of endopeptidase activityGO:0010951440.049
skeletal system developmentGO:00015013560.049
ribonucleotide metabolic processGO:00092592910.049
locomotory behaviorGO:00076261950.048
macromolecule deacylationGO:0098732370.048
pigment metabolic processGO:0042440320.048
positive regulation of protein modification by small protein conjugation or removalGO:1903322300.048
intestinal epithelial structure maintenanceGO:006072940.048
negative regulation of fibroblast proliferationGO:0048147140.048
nucleobase containing small molecule metabolic processGO:00550863520.048
regulation of cellular ketone metabolic process by regulation of transcription from rna polymerase ii promoterGO:007236470.047
cation homeostasisGO:00550802120.047
regulation of tor signalingGO:0032006170.047
regulation of gliogenesisGO:0014013500.047
purine ribonucleoside catabolic processGO:00461302050.047
regulation of protein modification by small protein conjugation or removalGO:1903320570.046
regulation of response to woundingGO:19030341890.045
regulation of cell motilityGO:20001452360.045
nuclear importGO:0051170950.045
Human
glandular epithelial cell differentiationGO:0002067380.045
appendage developmentGO:00487361660.045
cellular nitrogen compound catabolic processGO:00442702800.045
Human
morphogenesis of a branching epitheliumGO:00611381930.045
photoreceptor cell differentiationGO:0046530520.045
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:00900921120.045
regulation of protein import into nucleus translocationGO:003315820.044
Human
regulation of neuron deathGO:19012141340.044
rna splicingGO:0008380540.044
glucocorticoid secretionGO:003593360.044
regulation of protein transportGO:00512231630.044
Human
nucleus organizationGO:0006997450.044
negative regulation of cellular amine metabolic processGO:003323910.044
purine nucleoside metabolic processGO:00422782410.044
negative regulation of immune system processGO:00026832090.044
nucleotide metabolic processGO:00091173320.043
synaptic transmissionGO:00072683290.043
regulation of chromatin modificationGO:1903308570.043
Human Fly
ribonucleoside biosynthetic processGO:0042455210.043
regulation of peptide secretionGO:0002791770.043
regulation of striated muscle cell differentiationGO:0051153810.042
insulin secretionGO:0030073890.042
sequestering of calcium ionGO:0051208180.042
transmembrane transportGO:00550854120.042
rna processingGO:00063961050.041
stem cell proliferationGO:00720891170.041
regulation of cell cycle g1 s phase transitionGO:1902806350.041
adenylate cyclase activating g protein coupled receptor signaling pathwayGO:0007189300.041
telomere maintenanceGO:0000723190.041
cellular response to insulin stimulusGO:0032869780.041
Human
genitalia developmentGO:0048806370.041
mrna metabolic processGO:0016071840.041
positive regulation of dephosphorylationGO:003530660.041
aortic valve morphogenesisGO:000318040.040
carboxylic acid transportGO:00469421000.040
cellular divalent inorganic cation homeostasisGO:00725031270.040
wnt signaling pathwayGO:00160551880.040
regulation of cellular carbohydrate metabolic processGO:0010675750.040
regulation of g1 s transition of mitotic cell cycleGO:2000045350.040
regulation of canonical wnt signaling pathwayGO:0060828820.040
regulation of blood circulationGO:1903522930.040
negative regulation of homeostatic processGO:0032845710.040
positive regulation of epithelial cell proliferationGO:0050679680.040
dephosphorylationGO:00163111290.040
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071692470.040
Human
peptidyl lysine acetylationGO:0018394450.040
Human Worm Fly
purine ribonucleotide biosynthetic processGO:0009152590.040
bmp signaling pathwayGO:0030509930.040
purine ribonucleoside metabolic processGO:00461282410.040

Sirt1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of cellular proliferationDOID:1456600.781
organ system cancerDOID:005068600.781
cancerDOID:16200.781
gastrointestinal system cancerDOID:311900.202
colon cancerDOID:21900.202
large intestine cancerDOID:567200.202
intestinal cancerDOID:1015500.202
colorectal cancerDOID:925600.202
disease of metabolismDOID:001466700.165
nutrition diseaseDOID:37400.165
acquired metabolic diseaseDOID:006015800.165
carbohydrate metabolism diseaseDOID:005001300.118
type 2 diabetes mellitusDOID:935200.118
glucose metabolism diseaseDOID:419400.118
diabetes mellitusDOID:935100.118
thoracic cancerDOID:509300.041