IMP: Integrative Multi-species Prediction

Mus musculus

0 known processes

Phrf1

PHD and ring finger domains 1

(Aliases: AA673488)

Entrez: 101471
Ensembl: ENSMUSG00000038611
UniProtKB: A6H619

Process Predictions
Disease Predictions

Phrf1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
covalent chromatin modification	GO:0016569	163	0.153
macromolecule methylation	GO:0043414	120	0.106
intracellular mrna localization	GO:0008298	4	0.090
mrna splicing via spliceosome	GO:0000398	43	0.080	Fly
oocyte axis specification	GO:0007309	2	0.078
pole plasm assembly	GO:0007315	2	0.077
oocyte anterior posterior axis specification	GO:0007314	2	0.072
regulation of histone h3 k4 methylation	GO:0051569	12	0.072
histone lysine methylation	GO:0034968	50	0.070
chromatin modification	GO:0016568	187	0.068
histone methylation	GO:0016571	71	0.063
protein targeting	GO:0006605	143	0.062
histone modification	GO:0016570	159	0.056
protein acylation	GO:0043543	64	0.053
protein localization to organelle	GO:0033365	185	0.047
protein localization to nucleus	GO:0034504	121	0.046
oocyte construction	GO:0007308	2	0.043
protein dealkylation	GO:0008214	13	0.042
chromatin organization	GO:0006325	206	0.040
nuclear transport	GO:0051169	139	0.040
intracellular protein transport	GO:0006886	204	0.037
meiotic nuclear division	GO:0007126	115	0.036
regulation of binding	GO:0051098	111	0.035
protein methylation	GO:0006479	81	0.035
blastocyst development	GO:0001824	80	0.034
organelle fission	GO:0048285	170	0.033
purine nucleoside metabolic process	GO:0042278	241	0.033
nucleoside phosphate catabolic process	GO:1901292	222	0.033
macromolecule catabolic process	GO:0009057	281	0.033
germ cell development	GO:0007281	185	0.031
glycosyl compound metabolic process	GO:1901657	246	0.031
histone lysine demethylation	GO:0070076	13	0.030
meiotic cell cycle	GO:0051321	122	0.030
translation	GO:0006412	93	0.029
purine ribonucleoside monophosphate metabolic process	GO:0009167	80	0.029
cytoplasmic transport	GO:0016482	234	0.029
aromatic compound catabolic process	GO:0019439	286	0.028
nucleobase containing small molecule metabolic process	GO:0055086	352	0.028
cellular nitrogen compound catabolic process	GO:0044270	280	0.028
nuclear import	GO:0051170	95	0.028
nucleocytoplasmic transport	GO:0006913	139	0.028
ribonucleoside metabolic process	GO:0009119	245	0.028
protein modification by small protein conjugation or removal	GO:0070647	207	0.027
regulation of intracellular transport	GO:0032386	159	0.027
ribonucleotide catabolic process	GO:0009261	208	0.026
heterocycle catabolic process	GO:0046700	280	0.026
regulation of chromatin modification	GO:1903308	57	0.026
actin cytoskeleton organization	GO:0030036	220	0.026
methylation	GO:0032259	134	0.026
purine nucleotide metabolic process	GO:0006163	302	0.025
purine ribonucleoside metabolic process	GO:0046128	241	0.025
protein import into nucleus	GO:0006606	95	0.025
nuclear division	GO:0000280	158	0.025
carbohydrate derivative catabolic process	GO:1901136	231	0.025
stem cell proliferation	GO:0072089	117	0.025
peptidyl lysine modification	GO:0018205	77	0.024
regulation of establishment of protein localization	GO:0070201	181	0.023
ribonucleotide metabolic process	GO:0009259	291	0.023
stem cell fate specification	GO:0048866	3	0.023
peptidyl lysine acetylation	GO:0018394	45	0.023
lateral inhibition	GO:0046331	1	0.023
skeletal system development	GO:0001501	356	0.023
protein catabolic process	GO:0030163	221	0.023
regulation of transcription during meiosis	GO:0051037	1	0.022
dephosphorylation	GO:0016311	129	0.022
oogenesis	GO:0048477	56	0.022
negative regulation of cellular protein metabolic process	GO:0032269	247	0.022
histone acetylation	GO:0016573	41	0.022
peptidyl amino acid modification	GO:0018193	336	0.021
regulation of protein localization	GO:0032880	231	0.021
purine ribonucleotide metabolic process	GO:0009150	290	0.021
ubiquitin dependent protein catabolic process via the multivesicular body sorting pathway	GO:0043162	3	0.021
hematopoietic progenitor cell differentiation	GO:0002244	143	0.021
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.021
nucleoside metabolic process	GO:0009116	246	0.021
histone h3 k4 methylation	GO:0051568	23	0.021
regulation of apoptotic signaling pathway	GO:2001233	197	0.020
positive regulation of transcription elongation from rna polymerase ii promoter	GO:0032968	2	0.020
maternal determination of anterior posterior axis embryo	GO:0008358	2	0.020
nucleoside phosphate metabolic process	GO:0006753	338	0.020
protein alkylation	GO:0008213	81	0.020
internal protein amino acid acetylation	GO:0006475	42	0.020
regulation of organelle organization	GO:0033043	289	0.020
apoptotic signaling pathway	GO:0097190	306	0.020
protein demethylation	GO:0006482	13	0.019
glycosyl compound catabolic process	GO:1901658	206	0.019
nucleotide catabolic process	GO:0009166	217	0.019
purine nucleoside catabolic process	GO:0006152	205	0.019
establishment of protein localization to organelle	GO:0072594	118	0.019
single organism nuclear import	GO:1902593	95	0.019
ribose phosphate metabolic process	GO:0019693	291	0.018
regulation of hydrolase activity	GO:0051336	246	0.018
internal peptidyl lysine acetylation	GO:0018393	42	0.018
rhythmic process	GO:0048511	174	0.017
gene silencing by mirna	GO:0035195	10	0.017
regulation of nucleocytoplasmic transport	GO:0046822	73	0.017
spermatogenesis	GO:0007283	284	0.017
negative regulation of molecular function	GO:0044092	258	0.017
response to growth factor	GO:0070848	198	0.017
negative regulation of protein metabolic process	GO:0051248	282	0.017
purine ribonucleoside catabolic process	GO:0046130	205	0.017
zygotic determination of anterior posterior axis embryo	GO:0007354	3	0.016
mrna metabolic process	GO:0016071	84	0.016	Rat Fly
positive regulation of protein modification process	GO:0031401	299	0.016
circadian regulation of gene expression	GO:0032922	48	0.016
protein import	GO:0017038	101	0.016
male gamete generation	GO:0048232	285	0.016
neural precursor cell proliferation	GO:0061351	121	0.016
regulation of sequence specific dna binding transcription factor activity	GO:0051090	106	0.016
purine ribonucleotide catabolic process	GO:0009154	208	0.015
histone h3 acetylation	GO:0043966	14	0.015
nucleoside triphosphate catabolic process	GO:0009143	205	0.015
regulation of histone h3 k9 methylation	GO:0051570	8	0.015
rna splicing	GO:0008380	54	0.015	Fly
microtubule based process	GO:0007017	236	0.015
purine containing compound metabolic process	GO:0072521	311	0.015
maintenance of location	GO:0051235	89	0.015
nucleoside catabolic process	GO:0009164	206	0.014
positive regulation of nucleoside metabolic process	GO:0045979	91	0.014
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.014
rna localization	GO:0006403	23	0.014
regulation of chromosome organization	GO:0033044	83	0.014
female gamete generation	GO:0007292	74	0.014
regulation of cell activation	GO:0050865	289	0.014
cell adhesion	GO:0007155	329	0.014
respiratory tube development	GO:0030323	167	0.014
cellular amino acid metabolic process	GO:0006520	103	0.014
b cell activation	GO:0042113	161	0.013
regulation of purine nucleotide metabolic process	GO:1900542	169	0.013
posttranscriptional gene silencing by rna	GO:0035194	10	0.013
cellular response to dna damage stimulus	GO:0006974	207	0.013
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.013
modification dependent macromolecule catabolic process	GO:0043632	133	0.013
mitotic cytokinesis	GO:0000281	4	0.013
digestive system development	GO:0055123	200	0.013
rna splicing via transesterification reactions	GO:0000375	43	0.013	Fly
negative regulation of cell proliferation	GO:0008285	296	0.013
positive regulation of map kinase activity	GO:0043406	84	0.013
gonad development	GO:0008406	141	0.013
glycerolipid metabolic process	GO:0046486	122	0.013
negative regulation of sequence specific dna binding transcription factor activity	GO:0043433	40	0.013
endocytosis	GO:0006897	168	0.013
regulation of cell cell adhesion mediated by cadherin	GO:2000047	2	0.013
multi multicellular organism process	GO:0044706	109	0.013
regulation of cellular response to stress	GO:0080135	159	0.013
embryonic epithelial tube formation	GO:0001838	130	0.013
regulation of histone methylation	GO:0031060	30	0.013
connective tissue development	GO:0061448	179	0.013
positive regulation of gtp catabolic process	GO:0033126	85	0.012
digestive tract development	GO:0048565	190	0.012
leukocyte differentiation	GO:0002521	342	0.012
regulation of intrinsic apoptotic signaling pathway	GO:2001242	61	0.012
neuron apoptotic process	GO:0051402	142	0.012
histone demethylation	GO:0016577	13	0.012
microtubule cytoskeleton organization	GO:0000226	157	0.012
muscle tissue development	GO:0060537	308	0.012
epithelial cell development	GO:0002064	159	0.012
camera type eye development	GO:0043010	266	0.012
epithelial tube formation	GO:0072175	130	0.012
positive regulation of cell death	GO:0010942	224	0.012
development of primary sexual characteristics	GO:0045137	143	0.012
rna processing	GO:0006396	105	0.012	Rat Fly
cellular ketone metabolic process	GO:0042180	84	0.012
positive regulation of nervous system development	GO:0051962	221	0.012
nucleoside triphosphate metabolic process	GO:0009141	230	0.011
regulation of cellular ketone metabolic process	GO:0010565	66	0.011
mitotic cell cycle process	GO:1903047	159	0.011
modification dependent protein catabolic process	GO:0019941	133	0.011
response to organonitrogen compound	GO:0010243	246	0.011
tube closure	GO:0060606	91	0.011
purine nucleotide catabolic process	GO:0006195	211	0.011
positive regulation of mapk cascade	GO:0043410	170	0.011
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.011
rna interference	GO:0016246	2	0.011
circadian rhythm	GO:0007623	114	0.011
neuron death	GO:0070997	154	0.011
organic cyclic compound catabolic process	GO:1901361	295	0.011
negative regulation of proteolysis	GO:0045861	74	0.011
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.011
regulation of mrna metabolic process	GO:1903311	43	0.011	Fly
positive regulation of nucleotide catabolic process	GO:0030813	88	0.011
cellularization	GO:0007349	1	0.011
ribonucleoside triphosphate catabolic process	GO:0009203	199	0.011
cellular lipid metabolic process	GO:0044255	323	0.011
positive regulation of hormone metabolic process	GO:0032352	3	0.011
cellular response to lipid	GO:0071396	145	0.011
myeloid leukocyte differentiation	GO:0002573	119	0.011
inner cell mass cell proliferation	GO:0001833	15	0.011
regulation of multi organism process	GO:0043900	111	0.011
response to lipopolysaccharide	GO:0032496	128	0.011
regulation of mapk cascade	GO:0043408	248	0.011
regulation of protein processing	GO:0070613	96	0.011
regulation of cytoplasmic transport	GO:1903649	112	0.011
snrna metabolic process	GO:0016073	1	0.011
guanosine containing compound metabolic process	GO:1901068	144	0.011
positive regulation of protein phosphorylation	GO:0001934	242	0.011
protein ubiquitination	GO:0016567	171	0.010
positive regulation of mitotic metaphase anaphase transition	GO:0045842	2	0.010
transmembrane transport	GO:0055085	412	0.010
regulation of ras protein signal transduction	GO:0046578	114	0.010
regulation of cell cycle process	GO:0010564	160	0.010

Phrf1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.021
nervous system disease	DOID:863	0.021
eye and adnexa disease	DOID:1492	0.018
retinal disease	DOID:5679	0.018
retinal degeneration	DOID:8466	0.018
sensory system disease	DOID:0050155	0.018
eye disease	DOID:5614	0.018

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