Mus musculus

184 known processes

Rapgef1

Rap guanine nucleotide exchange factor (GEF) 1

(Aliases: 4932418O06Rik,C3G,Grf2)

Rapgef1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
small gtpase mediated signal transductionGO:0007264970.500
guanosine containing compound metabolic processGO:19010681440.451
guanosine containing compound catabolic processGO:19010691440.362
rho protein signal transductionGO:0007266320.339
gtp catabolic processGO:00061841430.315
regulation of ras protein signal transductionGO:00465781140.272
regulation of gtp catabolic processGO:00331241130.272
heterocycle catabolic processGO:00467002800.259
glycosyl compound catabolic processGO:19016582060.248
organophosphate catabolic processGO:00464342320.240
regulation of cellular catabolic processGO:00313292420.236
purine ribonucleotide catabolic processGO:00091542080.222
ras protein signal transductionGO:0007265770.220
organic cyclic compound catabolic processGO:19013612950.186
nucleoside triphosphate catabolic processGO:00091432050.184
regulation of mapk cascadeGO:00434082480.170
nucleoside catabolic processGO:00091642060.170
purine nucleotide metabolic processGO:00061633020.164
regulation of rho protein signal transductionGO:0035023710.163
Mouse
regulation of purine nucleotide catabolic processGO:00331211220.145
actin cytoskeleton organizationGO:00300362200.138
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071692470.126
regulation of purine nucleotide metabolic processGO:19005421690.122
cellular nitrogen compound catabolic processGO:00442702800.120
purine nucleoside triphosphate metabolic processGO:00091442260.117
regionalizationGO:00030023370.116
ribonucleoside triphosphate metabolic processGO:00091992200.115
regulation of cellular ketone metabolic processGO:0010565660.115
regulation of hydrolase activityGO:00513362460.111
purine nucleotide catabolic processGO:00061952110.109
ribonucleoside catabolic processGO:00424542060.109
regulation of nucleoside metabolic processGO:00091181300.107
ribonucleotide catabolic processGO:00092612080.107
regulation of nucleotide catabolic processGO:00308111220.107
mapk cascadeGO:00001652810.105
purine containing compound metabolic processGO:00725213110.099
rac protein signal transductionGO:0016601130.095
Mouse
regulation of rho gtpase activityGO:0032319580.095
Mouse
positive regulation of cellular catabolic processGO:00313311480.093
ribonucleoside metabolic processGO:00091192450.092
cellular ketone metabolic processGO:0042180840.092
purine containing compound catabolic processGO:00725232130.092
ribose phosphate metabolic processGO:00196932910.091
nucleoside triphosphate metabolic processGO:00091412300.090
negative regulation of phosphate metabolic processGO:00459361840.088
nucleotide metabolic processGO:00091173320.086
regulation of organelle organizationGO:00330432890.086
positive regulation of mapk cascadeGO:00434101700.085
myotube differentiationGO:00149021050.081
purine ribonucleoside metabolic processGO:00461282410.080
negative regulation of cellular amine metabolic processGO:003323910.079
nucleoside phosphate metabolic processGO:00067533380.079
purine nucleoside catabolic processGO:00061522050.077
carbohydrate derivative catabolic processGO:19011362310.075
negative regulation of cellular amino acid metabolic processGO:004576300.074
olfactory learningGO:000835520.073
membrane organizationGO:00610242450.072
negative regulation of protein tyrosine kinase activityGO:006109930.068
organonitrogen compound catabolic processGO:19015652640.064
cellular amino acid metabolic processGO:00065201030.063
aromatic compound catabolic processGO:00194392860.063
posttranscriptional regulation of gene expressionGO:00106081550.062
cellular amine metabolic processGO:0044106440.058
purine ribonucleoside triphosphate metabolic processGO:00092052200.056
synaptic transmissionGO:00072683290.055
Mouse
gtp metabolic processGO:00460391440.054
purine ribonucleotide metabolic processGO:00091502900.053
intracellular protein transportGO:00068862040.053
regulation of cellular amine metabolic processGO:0033238200.052
purine nucleoside triphosphate catabolic processGO:00091462030.052
glycosyl compound metabolic processGO:19016572460.051
negative regulation of transferase activityGO:0051348850.050
regulation of cellular component biogenesisGO:00440871810.049
Human
germ cell developmentGO:00072811850.048
purine ribonucleoside triphosphate catabolic processGO:00092071990.048
regulation of protein serine threonine kinase activityGO:00719001570.048
regulation of protein kinase activityGO:00458592320.047
nucleoside metabolic processGO:00091162460.047
cytoplasmic transportGO:00164822340.046
dna metabolic processGO:00062593030.045
negative regulation of cellular protein metabolic processGO:00322692470.045
negative regulation of protein modification processGO:00314001630.045
cell adhesionGO:00071553290.045
positive regulation of nucleotide catabolic processGO:0030813880.044
leukocyte differentiationGO:00025213420.044
Mouse
regulation of neuron projection developmentGO:00109751690.043
Human
regulation of neuron differentiationGO:00456642810.043
Human
nucleotide catabolic processGO:00091662170.043
regulation of nucleotide metabolic processGO:00061401690.042
regulation of actin cytoskeleton organizationGO:0032956840.041
regulation of cytoskeleton organizationGO:00514931220.041
negative regulation of protein metabolic processGO:00512482820.041
positive regulation of gtp catabolic processGO:0033126850.040
jnk cascadeGO:0007254720.040
nucleobase containing small molecule metabolic processGO:00550863520.040
ribonucleoside triphosphate catabolic processGO:00092031990.039
regulation of cytokine productionGO:00018172660.038
regulation of cell projection organizationGO:00313442060.038
Human
ribonucleotide metabolic processGO:00092592910.038
mitotic cell cycleGO:00002781950.035
Yeast
protein ubiquitinationGO:00165671710.035
muscle cell differentiationGO:00426922610.035
regulation of transmembrane transportGO:00347621280.034
Mouse
regulation of cellular amino acid metabolic processGO:000652150.034
spermatid differentiationGO:00485151150.033
gland developmentGO:00487323300.033
protein localization to organelleGO:00333651850.033
peptidyl serine modificationGO:0018209830.032
nucleoside phosphate catabolic processGO:19012922220.032
negative regulation of molecular functionGO:00440922580.032
negative regulation of cell proliferationGO:00082852960.032
positive regulation of cellular amino acid metabolic processGO:004576430.031
regulation of transferase activityGO:00513382630.031
positive regulation of gtpase activityGO:0043547850.030
regulation of cellular response to stressGO:00801351590.030
regulation of map kinase activityGO:00434051200.030
stress activated protein kinase signaling cascadeGO:0031098810.030
insulin receptor signaling pathwayGO:0008286490.029
syncytium formation by plasma membrane fusionGO:0000768420.029
negative regulation of protein phosphorylationGO:00019331260.029
regulation of erk1 and erk2 cascadeGO:0070372710.027
female gamete generationGO:0007292740.027
stress activated mapk cascadeGO:0051403800.027
protein modification by small protein conjugation or removalGO:00706472070.027
positive regulation of growthGO:00459271040.026
translationGO:0006412930.026
multicellular organismal signalingGO:0035637910.026
engulfment of apoptotic cellGO:004365230.026
regulation of leukocyte differentiationGO:19021051590.026
Mouse
cellularizationGO:000734910.026
regulation of proteolysisGO:00301621640.026
positive regulation of stress activated mapk cascadeGO:0032874480.026
purine ribonucleoside catabolic processGO:00461302050.026
developmental maturationGO:00217001930.025
positive regulation of cellular component biogenesisGO:0044089940.025
plasma membrane organizationGO:0007009900.025
regulation of jnk cascadeGO:0046328620.025
carbohydrate metabolic processGO:00059752300.025
positive regulation of purine nucleotide metabolic processGO:19005441140.025
cellular protein catabolic processGO:00442571550.025
male gamete generationGO:00482322850.024
spermatogenesisGO:00072832840.024
regulation of synaptic growth at neuromuscular junctionGO:000858240.024
positive regulation of nervous system developmentGO:00519622210.024
Human
positive regulation of jnk cascadeGO:0046330460.024
positive regulation of cellular amine metabolic processGO:003324050.024
epithelial cell proliferationGO:00506731740.024
activation of immune responseGO:00022531380.024
protein kinase b signalingGO:0043491740.024
response to organonitrogen compoundGO:00102432460.024
Human
protein localization to plasma membraneGO:0072659570.024
negative regulation of peptidyl tyrosine phosphorylationGO:0050732170.023
lateral inhibitionGO:004633110.023
cell fate commitmentGO:00451652100.022
regulation of protein localizationGO:00328802310.022
modification dependent protein catabolic processGO:00199411330.022
regulation of membrane potentialGO:00423911920.022
amine metabolic processGO:0009308450.022
vesicle organizationGO:0016050600.022
positive regulation of ras gtpase activityGO:0032320650.022
Human Yeast Mouse
regulation of t cell activationGO:00508631700.022
Mouse
mitochondrion organizationGO:00070051340.022
cellular response to dna damage stimulusGO:00069742070.022
lymphocyte differentiationGO:00300982420.022
Mouse
t cell activationGO:00421102890.022
Mouse
oocyte axis specificationGO:000730920.021
regulation of cell growthGO:0001558910.021
regulation of epithelial cell proliferationGO:00506781410.021
myeloid cell differentiationGO:00300992330.021
transmission of nerve impulseGO:0019226760.021
neural precursor cell proliferationGO:00613511210.021
regulation of rac protein signal transductionGO:0035020190.021
Mouse
regulation of anatomical structure sizeGO:00900661780.020
endomembrane system organizationGO:00102561470.020
positive regulation of protein catabolic processGO:0045732600.020
cellular lipid metabolic processGO:00442553230.020
purine nucleoside metabolic processGO:00422782410.020
establishment or maintenance of cell polarityGO:0007163860.020
spermatid developmentGO:00072861080.020
regulation of cell migrationGO:00303342190.020
nuclear transportGO:00511691390.020
negative regulation of cell activationGO:00508661110.020
negative regulation of cellular component organizationGO:00511291940.020
cell growthGO:00160491300.020
organelle localizationGO:00516401790.020
positive regulation of cell migrationGO:00303351090.020
inflammatory responseGO:00069542440.020
cell type specific apoptotic processGO:00972852680.020
blood vessel morphogenesisGO:00485142850.020
reactive oxygen species metabolic processGO:0072593840.020
establishment of protein localization to membraneGO:0090150540.020
regulation of kinase activityGO:00435492490.019
microtubule based processGO:00070172360.019
regulation of mitotic cell cycleGO:00073461260.019
Yeast
positive regulation of organelle organizationGO:00106381280.019
sensory organ morphogenesisGO:00905962420.019
negative regulation of phosphorylationGO:00423261660.019
regulation of striated muscle cell differentiationGO:0051153810.019
t cell differentiationGO:00302171740.019
Mouse
regulation of cellular component sizeGO:00325351210.019
regulation of cell activationGO:00508652890.019
Mouse
negative regulation of mapk cascadeGO:0043409650.019
positive regulation of protein transportGO:0051222930.018
regulation of system processGO:00440572000.018
cellular response to insulin stimulusGO:0032869780.018
single organism cell adhesionGO:00986021560.018
organelle fissionGO:00482851700.018
proteolysis involved in cellular protein catabolic processGO:00516031470.018
cardiac chamber developmentGO:00032051080.018
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:0002822870.018
action potentialGO:0001508780.018
homeostasis of number of cellsGO:00488722100.018
Mouse
positive regulation of purine nucleotide catabolic processGO:0033123880.018
stem cell differentiationGO:00488632680.018
fibroblast growth factor receptor signaling pathwayGO:0008543460.017
Mouse
oocyte constructionGO:000730820.017
response to growth factorGO:00708481980.017
Human Mouse
activation of mapk activityGO:0000187590.017
regulation of ras gtpase activityGO:0032318880.017
Human Yeast Mouse
regulation of epidermal growth factor activated receptor activityGO:000717670.017
chemotaxisGO:00069352470.017
transmembrane transportGO:00550854120.017
Mouse
endocytosisGO:00068971680.017
protein targetingGO:00066051430.017
regulation of reactive oxygen species metabolic processGO:2000377400.017
regulation of synaptic plasticityGO:0048167870.017
Mouse
macromolecule catabolic processGO:00090572810.017
positive regulation of nucleotide metabolic processGO:00459811140.017
positive regulation of neuron differentiationGO:00456661410.017
Human
negative regulation of epidermal growth factor activated receptor activityGO:000717530.016
dephosphorylationGO:00163111290.016
compound eye developmentGO:004874910.016
positive regulation of nucleoside metabolic processGO:0045979910.016
regulation of ion transmembrane transportGO:00347651190.016
Mouse
camera type eye developmentGO:00430102660.016
negative regulation of phosphorus metabolic processGO:00105631840.016
microtubule based transportGO:0010970500.016
cellular response to hormone stimulusGO:00328701500.016
regulation of mitotic cell cycle phase transitionGO:1901990730.016
Yeast
b cell activationGO:00421131610.015
positive regulation of cell developmentGO:00107202370.015
Human
regulation of vesicle mediated transportGO:00606271390.015
cellular response to organonitrogen compoundGO:00714171450.015
Human
negative regulation of cell cycleGO:00457861230.015
negative regulation of intracellular signal transductionGO:19025321670.015
regulation of stress activated mapk cascadeGO:0032872690.015
oogenesisGO:0048477560.015
regulation of lymphocyte activationGO:00512492400.015
Mouse
cation transportGO:00068123990.015
muscle cell developmentGO:00550011330.015
positive regulation of protein serine threonine kinase activityGO:00719021060.015
positive regulation of map kinase activityGO:0043406840.015
inorganic cation transmembrane transportGO:00986622070.015
humoral immune responseGO:0006959570.015
organ growthGO:00352651170.015
regulation of peptidyl tyrosine phosphorylationGO:0050730930.015
immune effector processGO:00022523210.015
innate immune responseGO:00450871570.015
negative regulation of synapse assemblyGO:005196430.015
protein localization to membraneGO:00726571080.015
protein maturationGO:00516041760.015
regulation of actin filament based processGO:0032970990.015
cell junction organizationGO:0034330770.015
Human
protein catabolic processGO:00301632210.014
cognitionGO:00508901490.014
symbiosis encompassing mutualism through parasitismGO:0044403830.014
regulation of adaptive immune responseGO:0002819900.014
heart morphogenesisGO:00030071780.014
regulation of proteasomal protein catabolic processGO:0061136460.014
angiogenesisGO:00015252010.014
epithelial cell developmentGO:00020641590.014
Human
renal system developmentGO:00720012250.014
response to peptideGO:19016521360.014
cardiac ventricle developmentGO:0003231830.013
cellular protein complex assemblyGO:00436231160.013
peptidyl amino acid modificationGO:00181933360.013
ossificationGO:00015032160.013
nucleocytoplasmic transportGO:00069131390.013
cytokine mediated signaling pathwayGO:00192211150.013
regulation of exit from mitosisGO:000709610.013
protein modification by small protein conjugationGO:00324461870.013
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:00900921120.013
regulation of sequence specific dna binding transcription factor activityGO:00510901060.013
axonogenesisGO:00074092740.013
dendrite developmentGO:00163581150.013
t cell proliferationGO:00420981200.013
Mouse
regulation of organ growthGO:0046620610.013
circulatory system processGO:00030131970.013
divalent inorganic cation transportGO:00725111780.013
neuronal action potentialGO:0019228540.013
cytokine productionGO:00018163190.013
positive regulation of cell projection organizationGO:0031346950.013
Human
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:00024601450.013
thymus developmentGO:0048538410.013
establishment of organelle localizationGO:00516561220.013
respiratory tube developmentGO:00303231670.013
blood circulationGO:00080151950.013
response to nutrient levelsGO:00316671090.012
placenta developmentGO:00018901400.012
pallium developmentGO:00215431200.012
regulation of ion transportGO:00432692150.012
Mouse
b cell differentiationGO:0030183780.012
positive regulation of hydrolase activityGO:00513451480.012
regulation of hippo signalingGO:003533010.012
t cell differentiation in thymusGO:0033077770.012
Mouse
intracellular mrna localizationGO:000829840.012
regulation of muscle tissue developmentGO:1901861970.012
positive regulation of transferase activityGO:00513471670.012
cell divisionGO:00513011200.012
maintenance of locationGO:0051235890.012
urogenital system developmentGO:00016552610.012
negative regulation of mitotic cell cycleGO:0045930580.012
negative regulation of cell cycle processGO:0010948690.012
cellular response to peptide hormone stimulusGO:0071375920.012
glycerolipid biosynthetic processGO:0045017500.012
regulation of lymphocyte mediated immunityGO:0002706840.012
single organism nuclear importGO:1902593950.012
regulation of cell morphogenesis involved in differentiationGO:00107691510.012
regulation of lymphocyte differentiationGO:00456191070.012
Mouse
positive regulation of neuron projection developmentGO:0010976790.012
Human
negative regulation of immune system processGO:00026832090.012
cell cell junction organizationGO:0045216720.012
regulation of t cell differentiationGO:0045580830.012
Mouse
locomotory behaviorGO:00076261950.012
cytoskeleton dependent intracellular transportGO:0030705500.012
negative regulation of nervous system developmentGO:00519611560.012
lymphocyte proliferationGO:00466511640.012
Mouse
actin polymerization or depolymerizationGO:0008154540.012
respiratory system developmentGO:00605411900.012
cellular carbohydrate metabolic processGO:00442621190.012
immune response activating signal transductionGO:00027571160.011
lung developmentGO:00303241640.011
cation transmembrane transportGO:00986552660.011
extracellular structure organizationGO:00430621480.011
establishment of vesicle localizationGO:0051650810.011
regulation of secretionGO:00510462740.011
positive regulation of cell activationGO:00508671580.011
fertilizationGO:00095661270.011
microtubule based movementGO:0007018840.011
leukocyte proliferationGO:00706611720.011
Mouse
peptidyl tyrosine phosphorylationGO:00181081430.011
positive regulation of cell growthGO:0030307330.011
multi organism behaviorGO:0051705620.011
negative regulation of receptor activityGO:200027250.011
positive regulation of erk1 and erk2 cascadeGO:0070374470.011
establishment of protein localization to organelleGO:00725941180.011
chromatin organizationGO:00063252060.011
skeletal system developmentGO:00015013560.011
regulation of epidermal growth factor receptor signaling pathwayGO:0042058130.011
divalent metal ion transportGO:00708381720.011
regulation of production of molecular mediator of immune responseGO:0002700650.011
activation of ras gtpase activityGO:0032856110.011
Mouse
negative regulation of apoptotic signaling pathwayGO:20012341040.011
phagocytosisGO:0006909660.011
adult locomotory behaviorGO:0008344910.011
response to oxidative stressGO:00069791230.011
striated muscle cell developmentGO:00550021250.011
gonad developmentGO:00084061410.011
neuron projection extensionGO:1990138640.011
regulation of cell projection assemblyGO:0060491380.010
leukocyte mediated immunityGO:00024431740.010
inositol lipid mediated signalingGO:0048017410.010
axon guidanceGO:00074111410.010
positive regulation of protein modification processGO:00314012990.010
regulation of apoptotic signaling pathwayGO:20012331970.010
developmental growth involved in morphogenesisGO:00605601380.010
myeloid leukocyte differentiationGO:00025731190.010
lens development in camera type eyeGO:0002088620.010
cellular response to peptideGO:1901653920.010
positive regulation of immune effector processGO:00026991070.010
neuron neuron synaptic transmissionGO:0007270690.010
keratinocyte differentiationGO:0030216480.010
regulation of leukocyte mediated immunityGO:00027031040.010
positive regulation of cell motilityGO:20001471160.010
ion transmembrane transportGO:00342203610.010
Mouse
regulation of receptor activityGO:0010469410.010
Mouse
cell matrix adhesionGO:0007160680.010
regulation of intracellular protein transportGO:0033157820.010
cellular response to lipidGO:00713961450.010
positive regulation of kinase activityGO:00336741550.010
mitochondrion distributionGO:004831140.010
positive regulation of lymphocyte activationGO:00512511400.010
methylationGO:00322591340.010
response to molecule of bacterial originGO:00022371430.010
ubiquitin dependent protein catabolic processGO:00065111290.010
cellular response to acid chemicalGO:0071229680.010

Rapgef1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.024
musculoskeletal system diseaseDOID:1700.024
nervous system diseaseDOID:86300.020
muscular diseaseDOID:008000000.019
disease of cellular proliferationDOID:1456600.017
cancerDOID:16200.017
neuropathyDOID:87000.016
muscle tissue diseaseDOID:6600.013
organ system cancerDOID:005068600.012