Mus musculus

31 known processes

Dot1l

DOT1-like, histone H3 methyltransferase (S. cerevisiae)

(Aliases: KMT4,Dot1,AW907654,mDot1,A630076O07)

Dot1l biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
covalent chromatin modificationGO:00165691630.150
actin cytoskeleton organizationGO:00300362200.110
striated muscle myosin thick filament assemblyGO:007168810.102
myosin filament assemblyGO:003103420.099
atrial ventricular junction remodelingGO:000329420.098
peripheral nervous system neuron axonogenesisGO:004893630.095
chromatin organizationGO:00063252060.079
negative regulation of cellular amino acid metabolic processGO:004576300.071
dna metabolic processGO:00062593030.067
negative regulation of cellular protein metabolic processGO:00322692470.066
negative regulation of cell proliferationGO:00082852960.062
av node cell to bundle of his cell communicationGO:008606720.058
negative regulation of protein metabolic processGO:00512482820.057
histone modificationGO:00165701590.056
leukocyte differentiationGO:00025213420.056
axonogenesisGO:00074092740.053
negative regulation of protein modification processGO:00314001630.050
sa node cell to atrial cardiac muscle cell signallingGO:008601840.048
regulation of protein kinase activityGO:00458592320.047
mitotic cell cycleGO:00002781950.047
cellular ketone metabolic processGO:0042180840.047
regulation of cellular amine metabolic processGO:0033238200.047
peptidyl amino acid modificationGO:00181933360.046
Human
muscle tissue developmentGO:00605373080.044
striated muscle tissue developmentGO:00147062930.042
regulation of cell cycleGO:00517262810.042
ras protein signal transductionGO:0007265770.039
embryonic placenta developmentGO:0001892980.039
amine metabolic processGO:0009308450.038
central nervous system neuron differentiationGO:00219531620.038
cell cycle switching mitotic to meiotic cell cycleGO:005172810.038
ion transmembrane transportGO:00342203610.037
organelle assemblyGO:00709251770.037
epithelial cell developmentGO:00020641590.036
regionalizationGO:00030023370.035
regulation of cellular amino acid metabolic processGO:000652150.035
male gamete generationGO:00482322850.034
embryonic organ morphogenesisGO:00485622760.034
oocyte axis specificationGO:000730920.034
mrna splicing via spliceosomeGO:0000398430.034
transmembrane transportGO:00550854120.033
regulation of transferase activityGO:00513382630.033
telencephalon developmentGO:00215371860.033
muscle cell differentiationGO:00426922610.033
mrna processingGO:0006397630.032
positive regulation of cellular amine metabolic processGO:003324050.032
chemotaxisGO:00069352470.032
gonad developmentGO:00084061410.031
respiratory system developmentGO:00605411900.031
negative regulation of molecular functionGO:00440922580.031
organonitrogen compound catabolic processGO:19015652640.030
spinal cord developmentGO:0021510810.030
myosin filament organizationGO:003103330.029
mrna metabolic processGO:0016071840.029
regulation of androgen receptor signaling pathwayGO:006076530.029
muscle cell developmentGO:00550011330.029
cellular amino acid metabolic processGO:00065201030.029
microtubule based processGO:00070172360.028
nitrogen compound transportGO:00717052710.028
organic cyclic compound catabolic processGO:19013612950.028
compound eye developmentGO:004874910.028
retina development in camera type eyeGO:00600411190.028
cation transportGO:00068123990.028
sensory organ morphogenesisGO:00905962420.027
negative regulation of cellular amine metabolic processGO:003323910.027
germ cell developmentGO:00072811850.027
small gtpase mediated signal transductionGO:0007264970.027
ventral spinal cord developmentGO:0021517480.027
cellular chemical homeostasisGO:00550822150.027
milk ejectionGO:006015610.026
stem cell developmentGO:00488642190.026
neuron projection guidanceGO:00974851410.026
meiotic cell cycleGO:00513211220.026
cardiac chamber developmentGO:00032051080.026
actin filament based movementGO:0030048230.026
cellular component assembly involved in morphogenesisGO:00109271390.025
branching morphogenesis of an epithelial tubeGO:00487541590.025
cardiac muscle cell contractionGO:008600370.025
foramen ovale closureGO:003592210.025
positive regulation of cellular amino acid metabolic processGO:004576430.025
camera type eye developmentGO:00430102660.024
cellular nitrogen compound catabolic processGO:00442702800.024
lymphocyte differentiationGO:00300982420.024
negative regulation of b cell receptor signaling pathwayGO:005085940.024
spermatogenesisGO:00072832840.024
cellular amine metabolic processGO:0044106440.024
protein acylationGO:0043543640.024
gene silencingGO:0016458380.024
regulation of cell activationGO:00508652890.023
dephosphorylationGO:00163111290.023
regulation of membrane potentialGO:00423911920.023
regulation of renin secretion into blood streamGO:190013340.023
bundle of his developmentGO:000316640.023
zygotic determination of anterior posterior axis embryoGO:000735430.023
regulation of cellular ketone metabolic processGO:0010565660.023
spermatid differentiationGO:00485151150.023
cell adhesionGO:00071553290.023
heterocycle catabolic processGO:00467002800.023
rna processingGO:00063961050.022
rna splicing via transesterification reactions with bulged adenosine as nucleophileGO:0000377430.022
regulation of cell cycle processGO:00105641600.022
epithelial tube morphogenesisGO:00605623030.022
regulation of striated muscle cell differentiationGO:0051153810.022
nucleoside phosphate metabolic processGO:00067533380.022
triglyceride metabolic processGO:0006641510.022
germline cell cycle switching mitotic to meiotic cell cycleGO:005172910.022
cellular lipid metabolic processGO:00442553230.022
glycerolipid metabolic processGO:00464861220.022
multicellular organismal signalingGO:0035637910.022
multicellular organism growthGO:00352641610.021
cell communication by electrical coupling involved in cardiac conductionGO:008606420.021
cardiac muscle tissue developmentGO:00487381300.021
myeloid cell differentiationGO:00300992330.021
ameboidal type cell migrationGO:00016671280.021
cellular ion homeostasisGO:00068731650.021
endodermal cell fate specificationGO:000171440.021
synapse organizationGO:00508081250.020
regulation of cellular catabolic processGO:00313292420.020
macromolecule catabolic processGO:00090572810.020
oocyte constructionGO:000730820.020
sequestering of calcium ionGO:0051208180.020
septum primum developmentGO:000328440.020
positive regulation of transcription elongation from rna polymerase ii promoterGO:003296820.020
dendrite developmentGO:00163581150.020
positive regulation of cell developmentGO:00107202370.020
organophosphate catabolic processGO:00464342320.020
negative regulation of lymphocyte activationGO:0051250910.020
development of primary sexual characteristicsGO:00451371430.019
rna interferenceGO:001624620.019
organonitrogen compound biosynthetic processGO:19015661920.019
transmission of nerve impulseGO:0019226760.019
positive regulation of cell adhesionGO:0045785800.019
regulation of tight junction assemblyGO:200081020.019
positive regulation of transferase activityGO:00513471670.019
protein methylationGO:0006479810.019
microtubule cytoskeleton organizationGO:00002261570.019
response to organonitrogen compoundGO:00102432460.019
placenta developmentGO:00018901400.019
membrane organizationGO:00610242450.019
sensory perceptionGO:00076002450.019
regulation of cytokine productionGO:00018172660.018
purine ribonucleotide metabolic processGO:00091502900.018
skeletal system morphogenesisGO:00487052030.018
blastocyst formationGO:0001825330.018
blastocyst developmentGO:0001824800.018
actin filament organizationGO:00070151130.018
mesodermal cell migrationGO:000807840.018
telencephalon cell migrationGO:0022029550.018
protein complex disassemblyGO:0043241400.018
dna recombinationGO:0006310920.018
regulation of secretionGO:00510462740.018
organic anion transportGO:00157111370.018
olfactory learningGO:000835520.018
negative regulation of transferase activityGO:0051348850.018
establishment of organelle localizationGO:00516561220.018
skeletal muscle organ developmentGO:00605381630.018
negative regulation of phosphate metabolic processGO:00459361840.017
cation homeostasisGO:00550802120.017
endocytosisGO:00068971680.017
cation transmembrane transportGO:00986552660.017
positive regulation of growthGO:00459271040.017
regulation of lymphocyte activationGO:00512492400.017
positive regulation of nervous system developmentGO:00519622210.017
myofibril assemblyGO:0030239340.017
internal protein amino acid acetylationGO:0006475420.017
cellular homeostasisGO:00197252400.017
digestive tract developmentGO:00485651900.017
regulation of organelle organizationGO:00330432890.017
morphogenesis of a branching structureGO:00017632030.017
neutral lipid metabolic processGO:0006638570.017
peripheral nervous system developmentGO:0007422530.017
regulation of kinase activityGO:00435492490.017
aromatic compound catabolic processGO:00194392860.017
protein modification by small protein conjugationGO:00324461870.016
stem cell differentiationGO:00488632680.016
negative regulation of mitotic cell cycleGO:0045930580.016
heart morphogenesisGO:00030071780.016
chromatin modificationGO:00165681870.016
rna splicing via transesterification reactionsGO:0000375430.016
mapk cascadeGO:00001652810.016
purine nucleoside metabolic processGO:00422782410.016
regulation of mitotic cell cycleGO:00073461260.016
neuroblast differentiationGO:001401620.016
protein catabolic processGO:00301632210.016
gonad morphogenesisGO:003526210.016
positive regulation of secondary heart field cardioblast proliferationGO:007251340.016
regulation of mapk cascadeGO:00434082480.016
protein alkylationGO:0008213810.016
nucleobase containing small molecule metabolic processGO:00550863520.016
histone acetylationGO:0016573410.016
cytokine productionGO:00018163190.016
inorganic ion transmembrane transportGO:00986602340.015
inorganic cation transmembrane transportGO:00986622070.015
oxidation reduction processGO:00551143420.015
regulation of cellular response to stressGO:00801351590.015
regulation of intracellular transportGO:00323861590.015
ensheathment of neuronsGO:0007272760.015
gland developmentGO:00487323300.015
sequestering of metal ionGO:0051238190.015
spermatid developmentGO:00072861080.015
canonical wnt signaling pathwayGO:00600701300.015
spinal cord motor neuron differentiationGO:0021522350.015
cell differentiation in spinal cordGO:0021515530.015
regulation of membrane depolarizationGO:0003254110.015
genitalia developmentGO:0048806370.015
ribonucleoside catabolic processGO:00424542060.015
regulation of cardiac chamber morphogenesisGO:190121920.015
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:0002822870.015
wnt signaling pathwayGO:00160551880.015
ribonucleotide metabolic processGO:00092592910.015
purine nucleotide metabolic processGO:00061633020.015
negative regulation of phosphorus metabolic processGO:00105631840.015
anatomical structure homeostasisGO:00602491450.015
cell communication by chemical couplingGO:001064320.015
developmental maturationGO:00217001930.015
cellular divalent inorganic cation homeostasisGO:00725031270.015
cellular response to organonitrogen compoundGO:00714171450.014
regulation of organ growthGO:0046620610.014
spleen developmentGO:0048536390.014
peptide transportGO:00158331330.014
striated muscle cell developmentGO:00550021250.014
sensory system developmentGO:004888030.014
gene silencing by rnaGO:0031047190.014
nucleoside metabolic processGO:00091162460.014
synaptic transmissionGO:00072683290.014
regulation of cell adhesionGO:00301551540.014
regulation of hormone levelsGO:00108172110.014
protein depolymerizationGO:0051261340.014
regulation of protein localizationGO:00328802310.014
rhythmic processGO:00485111740.014
negative regulation of t cell activationGO:0050868650.014
protein ubiquitinationGO:00165671710.014
regulation of ras protein signal transductionGO:00465781140.014
negative regulation of phosphorylationGO:00423261660.014
posttranscriptional regulation of gene expressionGO:00106081550.014
regulation of receptor activityGO:0010469410.014
locomotory behaviorGO:00076261950.014
neuroblast fate commitmentGO:001401710.014
protein localization to membraneGO:00726571080.014
positive regulation of creb transcription factor activityGO:003279340.014
endomembrane system organizationGO:00102561470.014
regulation of heart growthGO:0060420310.014
response to molecule of bacterial originGO:00022371430.014
cellular protein complex assemblyGO:00436231160.013
rho protein signal transductionGO:0007266320.013
appendage morphogenesisGO:00351071490.013
skeletal system developmentGO:00015013560.013
regulation of membrane depolarization during cardiac muscle cell action potentialGO:190082510.013
regulation of feeding behaviorGO:006025930.013
negative regulation of apoptotic signaling pathwayGO:20012341040.013
peptidyl lysine modificationGO:0018205770.013
Human
regulation of chromosome organizationGO:0033044830.013
divalent inorganic cation transportGO:00725111780.013
mitotic cell cycle processGO:19030471590.013
cellular metal ion homeostasisGO:00068751510.013
protein modification by small protein conjugation or removalGO:00706472070.013
proteasomal protein catabolic processGO:0010498980.013
gliogenesisGO:00420631410.013
regulation of purine nucleotide catabolic processGO:00331211220.013
lung developmentGO:00303241640.013
cytoplasmic transportGO:00164822340.013
positive regulation of gtpase activityGO:0043547850.013
peptidyl lysine acetylationGO:0018394450.013
regulation of defense responseGO:00313472330.013
positive regulation of cilium movementGO:000335310.013
positive regulation of dna templated transcription elongationGO:003278620.013
metencephalon developmentGO:0022037890.013
protein targetingGO:00066051430.013
embryonic epithelial tube formationGO:00018381300.013
intracellular protein transportGO:00068862040.013
nucleoside triphosphate catabolic processGO:00091432050.013
anion transportGO:00068201770.013
primary neural tube formationGO:0014020950.013
organ growthGO:00352651170.013
positive regulation of nucleotide catabolic processGO:0030813880.012
organelle localizationGO:00516401790.012
nuclear transportGO:00511691390.012
nucleocytoplasmic transportGO:00069131390.012
internal peptidyl lysine acetylationGO:0018393420.012
negative regulation of kinase activityGO:0033673810.012
negative regulation of leukocyte proliferationGO:0070664460.012
negative regulation of intracellular signal transductionGO:19025321670.012
purine containing compound metabolic processGO:00725213110.012
amide transportGO:00428861380.012
negative regulation of immune system processGO:00026832090.012
regulation of anatomical structure sizeGO:00900661780.012
positive regulation of purine nucleotide metabolic processGO:19005441140.012
modification dependent protein catabolic processGO:00199411330.012
ribonucleoside triphosphate metabolic processGO:00091992200.012
regulation of ion transportGO:00432692150.012
cellular protein catabolic processGO:00442571550.012
response to peptide hormoneGO:00434341270.012
molting cycleGO:0042303900.012
regulation of synaptic growth at neuromuscular junctionGO:000858240.012
pallium developmentGO:00215431200.012
purine nucleoside catabolic processGO:00061522050.012
axon guidanceGO:00074111410.012
single organism cell adhesionGO:00986021560.012
regulation of ventricular cardiac muscle cell membrane depolarizationGO:006037320.012
actomyosin structure organizationGO:0031032560.012
lateral inhibitionGO:004633110.012
positive regulation of neuron differentiationGO:00456661410.012
ribonucleoside metabolic processGO:00091192450.012
hematopoietic progenitor cell differentiationGO:00022441430.012
macromolecular complex disassemblyGO:0032984430.012
regulation of lymphocyte proliferationGO:00506701170.012
regulation of t cell activationGO:00508631700.012
sa node cell action potentialGO:008601540.012
neural tube closureGO:0001843900.012
regulation of lymphocyte mediated immunityGO:0002706840.012
positive regulation of defense responseGO:00313491240.012
glucose homeostasisGO:00425931280.012
platelet derived growth factor receptor signaling pathwayGO:0048008320.011
sensory perception of mechanical stimulusGO:00509541070.011
negative regulation of leukocyte differentiationGO:1902106510.011
cardiac septum developmentGO:0003279590.011
negative regulation of heart growthGO:006111770.011
regulation of secretion by cellGO:19035302490.011
gene silencing by mirnaGO:0035195100.011
forebrain developmentGO:00309003020.011
purine nucleoside triphosphate metabolic processGO:00091442260.011
regulation of establishment of protein localizationGO:00702011810.011
positive regulation of vasoconstrictionGO:004590740.011
regulation of cellular component biogenesisGO:00440871810.011
stem cell maintenanceGO:00198271300.011
t cell activationGO:00421102890.011
carbohydrate metabolic processGO:00059752300.011
regulation of lymphocyte differentiationGO:00456191070.011
ventricular cardiac muscle cell action potentialGO:008600540.011
cellular response to dna damage stimulusGO:00069742070.011
female gamete generationGO:0007292740.011
posttranscriptional gene silencingGO:0016441100.011
actin mediated cell contractionGO:0070252150.011
rna splicingGO:0008380540.011
myelinationGO:0042552740.011
regulation of purine nucleotide metabolic processGO:19005421690.011
lens development in camera type eyeGO:0002088620.011
purine ribonucleoside metabolic processGO:00461282410.011
purine ribonucleoside triphosphate catabolic processGO:00092071990.011
purine ribonucleoside triphosphate metabolic processGO:00092052200.011
regulation of protein serine threonine kinase activityGO:00719001570.011
cell growthGO:00160491300.011
directional locomotionGO:003305830.011
purine containing compound catabolic processGO:00725232130.011
actin polymerization or depolymerizationGO:0008154540.011
cellular response to lipidGO:00713961450.011
regulation of meiotic cell cycleGO:0051445340.011
p38mapk cascadeGO:003806640.011
regulation of behavioral fear responseGO:200082220.011
regulation of reactive oxygen species biosynthetic processGO:190342620.011
guanosine containing compound catabolic processGO:19010691440.011
response to lipopolysaccharideGO:00324961280.011
lymphocyte mediated immunityGO:00024491390.011
cell activation involved in immune responseGO:00022631260.011
regulation of protein transportGO:00512231630.011
kidney developmentGO:00018222130.011
regulation of ion transmembrane transportGO:00347651190.011
negative regulation of protein phosphorylationGO:00019331260.011
positive regulation of cellular catabolic processGO:00313311480.011
regulation of leukocyte mediated immunityGO:00027031040.011
immunoglobulin productionGO:0002377730.011
proteolysis involved in cellular protein catabolic processGO:00516031470.010
translationGO:0006412930.010
developmental cell growthGO:0048588840.010
establishment of blood nerve barrierGO:000806530.010
cerebral cortex developmentGO:0021987860.010
purine nucleoside triphosphate catabolic processGO:00091462030.010
localization within membraneGO:005166840.010
peptide secretionGO:00027901140.010
cellular protein complex disassemblyGO:0043624360.010
regulation of ion homeostasisGO:2000021640.010
rac protein signal transductionGO:0016601130.010
positive regulation of immune effector processGO:00026991070.010
protein secretionGO:00093061110.010
action potentialGO:0001508780.010
protein localization to nucleusGO:00345041210.010
ribose phosphate metabolic processGO:00196932910.010
regulation of rna splicingGO:0043484370.010
cell cycle g1 s phase transitionGO:0044843570.010
regulation of adaptive immune responseGO:0002819900.010
epithelial tube formationGO:00721751300.010

Dot1l disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.030
nervous system diseaseDOID:86300.030
musculoskeletal system diseaseDOID:1700.028
muscular diseaseDOID:008000000.027
muscle tissue diseaseDOID:6600.027
bone diseaseDOID:008000100.022
bone development diseaseDOID:008000600.022
connective tissue diseaseDOID:6500.022
muscular dystrophyDOID:988400.020
myopathyDOID:42300.020
immune system diseaseDOID:291400.019
cardiovascular system diseaseDOID:128700.017
heart diseaseDOID:11400.017
hematopoietic system diseaseDOID:7400.015
disease of cellular proliferationDOID:1456600.013
cancerDOID:16200.013
organ system cancerDOID:005068600.013
hematologic cancerDOID:253100.013
immune system cancerDOID:006008300.013
cardiomyopathyDOID:005070000.013
intrinsic cardiomyopathyDOID:006003600.013
dysostosisDOID:193400.012
central nervous system diseaseDOID:33100.010