IMP: Integrative Multi-species Prediction

Mus musculus

0 known processes

Sdha

succinate dehydrogenase complex, subunit A, flavoprotein (Fp)

(Aliases: FP,1500032O14Rik,SDH2,2310034D06Rik,4921513A11,C81073,SDHF)

Ensembl: ENSMUSG00000021577
Entrez: 66945
UniProtKB: Q8K2B3

Process Predictions
Disease Predictions

Sdha biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
oxidation reduction process	GO:0055114	342	0.943	Yeast
energy derivation by oxidation of organic compounds	GO:0015980	77	0.783	Yeast
generation of precursor metabolites and energy	GO:0006091	103	0.701	Yeast
coenzyme metabolic process	GO:0006732	52	0.627
fatty acid oxidation	GO:0019395	28	0.355
small molecule catabolic process	GO:0044282	71	0.320
cellular respiration	GO:0045333	38	0.235	Yeast
mitochondrion organization	GO:0007005	134	0.195
nadh metabolic process	GO:0006734	1	0.195
monocarboxylic acid metabolic process	GO:0032787	191	0.191
lipid oxidation	GO:0034440	29	0.183
acetyl coa biosynthetic process from pyruvate	GO:0006086	3	0.182
coenzyme biosynthetic process	GO:0009108	23	0.170
thioester metabolic process	GO:0035383	19	0.167
transmembrane transport	GO:0055085	412	0.164
cellular amino acid metabolic process	GO:0006520	103	0.151
acetyl coa biosynthetic process	GO:0006085	5	0.125
mitochondrial translation	GO:0032543	4	0.124
cellular ketone metabolic process	GO:0042180	84	0.113
nucleotide metabolic process	GO:0009117	332	0.112	Yeast
organic cyclic compound catabolic process	GO:1901361	295	0.091
fatty acid catabolic process	GO:0009062	25	0.086
carboxylic acid catabolic process	GO:0046395	51	0.081
protein targeting	GO:0006605	143	0.079
acyl coa metabolic process	GO:0006637	19	0.079
organic acid catabolic process	GO:0016054	51	0.073
nucleoside phosphate metabolic process	GO:0006753	338	0.071	Yeast
cellular nitrogen compound catabolic process	GO:0044270	280	0.070
citrate metabolic process	GO:0006101	3	0.068
nucleobase containing small molecule metabolic process	GO:0055086	352	0.068	Yeast
heterocycle catabolic process	GO:0046700	280	0.067
sulfur compound metabolic process	GO:0006790	100	0.066
thioester biosynthetic process	GO:0035384	7	0.065
regulation of cellular ketone metabolic process	GO:0010565	66	0.064
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.064	Yeast
organonitrogen compound catabolic process	GO:1901565	264	0.059
lipid catabolic process	GO:0016042	69	0.058
glycosyl compound metabolic process	GO:1901657	246	0.057	Yeast
cellular lipid metabolic process	GO:0044255	323	0.057
tricarboxylic acid metabolic process	GO:0072350	5	0.057
organic hydroxy compound metabolic process	GO:1901615	203	0.053
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.052	Yeast
mitochondrial membrane organization	GO:0007006	26	0.051
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.051
aromatic compound catabolic process	GO:0019439	286	0.050
protein localization to organelle	GO:0033365	185	0.049
alpha amino acid metabolic process	GO:1901605	59	0.047
cellular macromolecule catabolic process	GO:0044265	206	0.046
intracellular protein transport	GO:0006886	204	0.044
succinyl coa metabolic process	GO:0006104	1	0.043
organophosphate catabolic process	GO:0046434	232	0.041
translation	GO:0006412	93	0.040
carnitine metabolic process	GO:0009437	7	0.040
inorganic ion transmembrane transport	GO:0098660	234	0.039
regulation of mitochondrion organization	GO:0010821	27	0.039
purine ribonucleotide metabolic process	GO:0009150	290	0.039	Yeast
ether metabolic process	GO:0018904	2	0.038
regulation of cellular amino acid metabolic process	GO:0006521	5	0.038
neuron apoptotic process	GO:0051402	142	0.038
mitochondrial transport	GO:0006839	36	0.038
purine nucleoside metabolic process	GO:0042278	241	0.037	Yeast
cell type specific apoptotic process	GO:0097285	268	0.037
negative regulation of cell proliferation	GO:0008285	296	0.036
regulation of membrane potential	GO:0042391	192	0.036
protein oxidation	GO:0018158	2	0.035
cellular modified amino acid metabolic process	GO:0006575	63	0.035
cellular amino acid catabolic process	GO:0009063	25	0.035
negative regulation of phosphorus metabolic process	GO:0010563	184	0.034
intrinsic apoptotic signaling pathway	GO:0097193	132	0.034
hepaticobiliary system development	GO:0061008	67	0.034
neuron death	GO:0070997	154	0.034
apoptotic signaling pathway	GO:0097190	306	0.034
response to oxidative stress	GO:0006979	123	0.033
ribonucleoside catabolic process	GO:0042454	206	0.033
purine containing compound catabolic process	GO:0072523	213	0.033
endocytosis	GO:0006897	168	0.033
cellular lipid catabolic process	GO:0044242	52	0.033
sulfur compound biosynthetic process	GO:0044272	37	0.032
purine ribonucleoside metabolic process	GO:0046128	241	0.032	Yeast
dicarboxylic acid metabolic process	GO:0043648	18	0.032
cellular amine metabolic process	GO:0044106	44	0.032
purine nucleotide catabolic process	GO:0006195	211	0.031
establishment of protein localization to peroxisome	GO:0072663	4	0.031
amine metabolic process	GO:0009308	45	0.031
nitrogen compound transport	GO:0071705	271	0.031
ribonucleotide metabolic process	GO:0009259	291	0.030	Yeast
ribose phosphate metabolic process	GO:0019693	291	0.030	Yeast
cation transport	GO:0006812	399	0.029
nucleoside triphosphate metabolic process	GO:0009141	230	0.029	Yeast
homeostasis of number of cells	GO:0048872	210	0.029
atp metabolic process	GO:0046034	75	0.029	Yeast
microtubule based process	GO:0007017	236	0.029
establishment of protein localization to organelle	GO:0072594	118	0.029
regulation of intrinsic apoptotic signaling pathway	GO:2001242	61	0.028
medium chain fatty acid metabolic process	GO:0051791	1	0.027
purine nucleotide metabolic process	GO:0006163	302	0.027	Yeast
monocarboxylic acid biosynthetic process	GO:0072330	61	0.027
macromolecule catabolic process	GO:0009057	281	0.027
fatty acid beta oxidation	GO:0006635	16	0.027
lipid localization	GO:0010876	126	0.026
reactive oxygen species metabolic process	GO:0072593	84	0.026
regulation of neuron death	GO:1901214	134	0.026
lipid biosynthetic process	GO:0008610	179	0.026
microtubule cytoskeleton organization	GO:0000226	157	0.026
regulation of mitochondrial fission	GO:0090140	3	0.025
fatty acid metabolic process	GO:0006631	121	0.025
atp catabolic process	GO:0006200	55	0.025
nucleoside metabolic process	GO:0009116	246	0.025	Yeast
cation transmembrane transport	GO:0098655	266	0.025
carbohydrate derivative catabolic process	GO:1901136	231	0.025
negative regulation of phosphorylation	GO:0042326	166	0.025
peptidyl amino acid modification	GO:0018193	336	0.024
positive regulation of protein modification process	GO:0031401	299	0.024
carboxylic acid biosynthetic process	GO:0046394	86	0.024
positive regulation of cellular amine metabolic process	GO:0033240	5	0.024
positive regulation of mapk cascade	GO:0043410	170	0.024
ribonucleoside metabolic process	GO:0009119	245	0.024	Yeast
regulation of cellular amine metabolic process	GO:0033238	20	0.024
ribonucleotide catabolic process	GO:0009261	208	0.023
protein import	GO:0017038	101	0.023
purine ribonucleoside catabolic process	GO:0046130	205	0.023
regulation of cellular catabolic process	GO:0031329	242	0.023
small molecule biosynthetic process	GO:0044283	132	0.022
nuclear transport	GO:0051169	139	0.022
nicotinamide nucleotide metabolic process	GO:0046496	12	0.022
male gamete generation	GO:0048232	285	0.022
energy reserve metabolic process	GO:0006112	39	0.022
organic acid biosynthetic process	GO:0016053	86	0.021
cellular homeostasis	GO:0019725	240	0.021
nucleoside phosphate catabolic process	GO:1901292	222	0.021
purine ribonucleotide catabolic process	GO:0009154	208	0.021
protein oligomerization	GO:0051259	67	0.021
cellular carbohydrate metabolic process	GO:0044262	119	0.021
nucleotide catabolic process	GO:0009166	217	0.021
inorganic cation transmembrane transport	GO:0098662	207	0.021
cellular alcohol metabolic process	GO:0044107	3	0.021
positive regulation of protein phosphorylation	GO:0001934	242	0.020
response to oxygen radical	GO:0000305	16	0.020
cytoplasmic transport	GO:0016482	234	0.020
response to inorganic substance	GO:0010035	96	0.020
alpha amino acid catabolic process	GO:1901606	18	0.020
epithelial cell proliferation	GO:0050673	174	0.020
purine nucleoside monophosphate catabolic process	GO:0009128	58	0.020
ribonucleoside triphosphate catabolic process	GO:0009203	199	0.020
gland development	GO:0048732	330	0.019
glycerol ether metabolic process	GO:0006662	2	0.019
establishment of protein localization to membrane	GO:0090150	54	0.019
regulation of transferase activity	GO:0051338	263	0.019
myeloid cell differentiation	GO:0030099	233	0.019
action potential	GO:0001508	78	0.019
regulation of organelle organization	GO:0033043	289	0.019
extrinsic apoptotic signaling pathway	GO:0097191	126	0.019
posttranscriptional regulation of gene expression	GO:0010608	155	0.019
regulation of cellular response to stress	GO:0080135	159	0.019
negative regulation of phosphate metabolic process	GO:0045936	184	0.019
response to molecule of bacterial origin	GO:0002237	143	0.018
fatty acid alpha oxidation	GO:0001561	2	0.018
glycogen biosynthetic process	GO:0005978	14	0.018
regulation of apoptotic signaling pathway	GO:2001233	197	0.018
aldehyde catabolic process	GO:0046185	4	0.018
mitochondrion degradation	GO:0000422	3	0.018
glycogen metabolic process	GO:0005977	32	0.018
response to organonitrogen compound	GO:0010243	246	0.018
regulation of peptide transport	GO:0090087	91	0.018
purine nucleoside catabolic process	GO:0006152	205	0.018
regulation of reactive oxygen species metabolic process	GO:2000377	40	0.018
protein localization to membrane	GO:0072657	108	0.018
reactive nitrogen species metabolic process	GO:2001057	0	0.017
regulation of kinase activity	GO:0043549	249	0.017
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.017
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.017
ion transmembrane transport	GO:0034220	361	0.017
germ cell development	GO:0007281	185	0.017
glucose homeostasis	GO:0042593	128	0.017
response to organic cyclic compound	GO:0014070	198	0.017
transmission of nerve impulse	GO:0019226	76	0.017
membrane organization	GO:0061024	245	0.017
ribonucleoside monophosphate catabolic process	GO:0009158	57	0.017
regulation of lymphocyte activation	GO:0051249	240	0.017
positive regulation of protein kinase activity	GO:0045860	144	0.017
cellular polysaccharide metabolic process	GO:0044264	38	0.017
anion transport	GO:0006820	177	0.017
lymphocyte proliferation	GO:0046651	164	0.016
reactive oxygen species biosynthetic process	GO:1903409	8	0.016
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.016
nucleoside triphosphate catabolic process	GO:0009143	205	0.016
hydrogen ion transmembrane transport	GO:1902600	25	0.016
cytokine production	GO:0001816	319	0.016
liver development	GO:0001889	66	0.016
negative regulation of cellular protein metabolic process	GO:0032269	247	0.016
amino acid betaine metabolic process	GO:0006577	7	0.016
regulation of cell activation	GO:0050865	289	0.016
regulation of reactive oxygen species biosynthetic process	GO:1903426	2	0.016
neuronal action potential	GO:0019228	54	0.016
ossification	GO:0001503	216	0.016
nucleoside catabolic process	GO:0009164	206	0.016
lipid modification	GO:0030258	65	0.016
regulation of establishment of protein localization	GO:0070201	181	0.016
peptide transport	GO:0015833	133	0.016
pyridine containing compound metabolic process	GO:0072524	14	0.016
regulation of secretion by cell	GO:1903530	249	0.016
amide transport	GO:0042886	138	0.016
leukocyte differentiation	GO:0002521	342	0.015
regulation of cytokine production	GO:0001817	266	0.015
regulation of protein kinase activity	GO:0045859	232	0.015
maintenance of location	GO:0051235	89	0.015
forebrain development	GO:0030900	302	0.015
negative regulation of intracellular signal transduction	GO:1902532	167	0.015
cell maturation	GO:0048469	127	0.015
nucleoside monophosphate catabolic process	GO:0009125	59	0.015
regulation of neuron apoptotic process	GO:0043523	122	0.015
telencephalon development	GO:0021537	186	0.015
response to testosterone	GO:0033574	3	0.015
regulation of extrinsic apoptotic signaling pathway	GO:2001236	77	0.015
purine nucleoside monophosphate metabolic process	GO:0009126	81	0.015	Yeast
fat cell differentiation	GO:0045444	160	0.014
protein homooligomerization	GO:0051260	43	0.014
carbohydrate metabolic process	GO:0005975	230	0.014
negative regulation of intrinsic apoptotic signaling pathway	GO:2001243	34	0.014
cellular response to oxidative stress	GO:0034599	76	0.014
intrinsic apoptotic signaling pathway in response to dna damage	GO:0008630	57	0.014
nucleocytoplasmic transport	GO:0006913	139	0.014
regulation of protein serine threonine kinase activity	GO:0071900	157	0.014
purine ribonucleoside monophosphate catabolic process	GO:0009169	57	0.014
response to peptide	GO:1901652	136	0.013
oxidoreduction coenzyme metabolic process	GO:0006733	16	0.013
regulation of leukocyte differentiation	GO:1902105	159	0.013
cerebellum development	GO:0021549	77	0.013
organonitrogen compound biosynthetic process	GO:1901566	192	0.013
positive regulation of protein serine threonine kinase activity	GO:0071902	106	0.013
negative regulation of protein phosphorylation	GO:0001933	126	0.013
regulation of epithelial cell proliferation	GO:0050678	141	0.013
metencephalon development	GO:0022037	89	0.013
glucan metabolic process	GO:0044042	32	0.013
protein maturation	GO:0051604	176	0.013
response to oxygen levels	GO:0070482	62	0.013
cofactor biosynthetic process	GO:0051188	41	0.013
positive regulation of cell death	GO:0010942	224	0.013
nucleoside monophosphate metabolic process	GO:0009123	85	0.013	Yeast
positive regulation of reactive oxygen species biosynthetic process	GO:1903428	2	0.013
response to reactive oxygen species	GO:0000302	56	0.013
response to starvation	GO:0042594	65	0.013
pyridine nucleotide metabolic process	GO:0019362	12	0.013
positive regulation of mitochondrion organization	GO:0010822	17	0.013
negative regulation of cell development	GO:0010721	169	0.013
spermatogenesis	GO:0007283	284	0.013
negative regulation of molecular function	GO:0044092	258	0.013
positive regulation of transferase activity	GO:0051347	167	0.013
cellular glucan metabolic process	GO:0006073	32	0.013
phagocytosis	GO:0006909	66	0.013
negative regulation of protein metabolic process	GO:0051248	282	0.013
protein transmembrane transport	GO:0071806	8	0.012
response to lipopolysaccharide	GO:0032496	128	0.012
muscle tissue development	GO:0060537	308	0.012
regulation of glucose metabolic process	GO:0010906	60	0.012
negative regulation of neuron apoptotic process	GO:0043524	92	0.012
positive regulation of reactive oxygen species metabolic process	GO:2000379	11	0.012
negative regulation of cellular amino acid metabolic process	GO:0045763	0	0.012
regulation of protein transport	GO:0051223	163	0.012
nad metabolic process	GO:0019674	7	0.012
protein localization to nucleus	GO:0034504	121	0.012
protein processing	GO:0016485	163	0.012
multicellular organismal homeostasis	GO:0048871	164	0.012
immune effector process	GO:0002252	321	0.012
purine ribonucleoside monophosphate metabolic process	GO:0009167	80	0.012	Yeast
striated muscle tissue development	GO:0014706	293	0.012
regulation of cell cycle process	GO:0010564	160	0.012
regulation of protein localization	GO:0032880	231	0.012
protein catabolic process	GO:0030163	221	0.012
myeloid cell homeostasis	GO:0002262	114	0.012
anatomical structure homeostasis	GO:0060249	145	0.012
leukocyte proliferation	GO:0070661	172	0.012
adult behavior	GO:0030534	135	0.012
ribonucleoside monophosphate metabolic process	GO:0009161	80	0.012	Yeast
dna metabolic process	GO:0006259	303	0.012
ensheathment of neurons	GO:0007272	76	0.012
cellular response to lipid	GO:0071396	145	0.012
cellular response to lipopolysaccharide	GO:0071222	77	0.012
axon ensheathment	GO:0008366	76	0.011
regulation of carbohydrate metabolic process	GO:0006109	75	0.011
positive regulation of organelle organization	GO:0010638	128	0.011
monocarboxylic acid catabolic process	GO:0072329	27	0.011
lymphocyte differentiation	GO:0030098	242	0.011
mapk cascade	GO:0000165	281	0.011
extracellular matrix organization	GO:0030198	147	0.011
endomembrane system organization	GO:0010256	147	0.011
cellular component assembly involved in morphogenesis	GO:0010927	139	0.011
dna catabolic process endonucleolytic	GO:0000737	15	0.011
tissue homeostasis	GO:0001894	115	0.011
hydrogen transport	GO:0006818	35	0.011
t cell differentiation	GO:0030217	174	0.011
carbohydrate derivative biosynthetic process	GO:1901137	183	0.011
cellular response to organonitrogen compound	GO:0071417	145	0.011
aerobic respiration	GO:0009060	7	0.011
cell adhesion	GO:0007155	329	0.011
dephosphorylation	GO:0016311	129	0.011
sensory perception	GO:0007600	245	0.011
cellular ion homeostasis	GO:0006873	165	0.011
histone modification	GO:0016570	159	0.011
regulation of hydrolase activity	GO:0051336	246	0.011
cation homeostasis	GO:0055080	212	0.011
engulfment of apoptotic cell	GO:0043652	3	0.011
locomotory behavior	GO:0007626	195	0.011
sensory organ morphogenesis	GO:0090596	242	0.011
regulation of mitochondrial membrane potential	GO:0051881	17	0.011
positive regulation of growth	GO:0045927	104	0.011
t cell activation	GO:0042110	289	0.011
negative regulation of neuron death	GO:1901215	98	0.011
epithelial cell development	GO:0002064	159	0.011
rna processing	GO:0006396	105	0.011
iron sulfur cluster assembly	GO:0016226	3	0.010
negative regulation of transferase activity	GO:0051348	85	0.010
gonad development	GO:0008406	141	0.010
neural precursor cell proliferation	GO:0061351	121	0.010
negative regulation of protein modification process	GO:0031400	163	0.010
response to nutrient levels	GO:0031667	109	0.010
cellular response to cytokine stimulus	GO:0071345	189	0.010
embryonic epithelial tube formation	GO:0001838	130	0.010
urogenital system development	GO:0001655	261	0.010
regulation of interleukin 8 production	GO:0032677	3	0.010
regulation of cellular carbohydrate metabolic process	GO:0010675	75	0.010
response to endoplasmic reticulum stress	GO:0034976	53	0.010
purine containing compound metabolic process	GO:0072521	311	0.010	Yeast
protein import into nucleus	GO:0006606	95	0.010
regulation of t cell activation	GO:0050863	170	0.010
negative regulation of kinase activity	GO:0033673	81	0.010
neuron migration	GO:0001764	122	0.010
i kappab kinase nf kappab signaling	GO:0007249	85	0.010
isoprenoid metabolic process	GO:0006720	29	0.010
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.010	Yeast
multicellular organism growth	GO:0035264	161	0.010
inflammatory response	GO:0006954	244	0.010
cellular response to biotic stimulus	GO:0071216	92	0.010

Sdha disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
disease of metabolism	DOID:0014667	0.682
inherited metabolic disorder	DOID:655	0.359
amino acid metabolic disorder	DOID:9252	0.119
cancer	DOID:162	0.101
disease of cellular proliferation	DOID:14566	0.101
organ system cancer	DOID:0050686	0.061
organic acidemia	DOID:0060159	0.052
endocrine gland cancer	DOID:170	0.051
nervous system disease	DOID:863	0.048
disease of anatomical entity	DOID:7	0.048
gastrointestinal system cancer	DOID:3119	0.030
neurodegenerative disease	DOID:1289	0.023
central nervous system disease	DOID:331	0.023
sensory system disease	DOID:0050155	0.011
eye disease	DOID:5614	0.011
eye and adnexa disease	DOID:1492	0.011

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