IMP: Integrative Multi-species Prediction

Mus musculus

0 known processes

Timm17a

translocase of inner mitochondrial membrane 17a

(Aliases: mTim17a,17kDa)

Entrez: 21854
Ensembl: ENSMUSG00000062580
UniProtKB: Q9Z0V8
UniProtKB: Q545U2

Process Predictions
Disease Predictions

Timm17a biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
purine ribonucleoside metabolic process	GO:0046128	241	0.371
apoptotic signaling pathway	GO:0097190	306	0.331
purine ribonucleotide metabolic process	GO:0009150	290	0.308
regulation of apoptotic signaling pathway	GO:2001233	197	0.299
regulation of intrinsic apoptotic signaling pathway	GO:2001242	61	0.254
nucleoside triphosphate metabolic process	GO:0009141	230	0.252
regulation of hydrolase activity	GO:0051336	246	0.251
purine containing compound metabolic process	GO:0072521	311	0.215
mitochondrion organization	GO:0007005	134	0.191
cellular macromolecule catabolic process	GO:0044265	206	0.157
positive regulation of hydrolase activity	GO:0051345	148	0.145
intrinsic apoptotic signaling pathway	GO:0097193	132	0.130
nucleobase containing small molecule metabolic process	GO:0055086	352	0.125
regulation of membrane potential	GO:0042391	192	0.119
regulation of cellular catabolic process	GO:0031329	242	0.119
transmembrane transport	GO:0055085	412	0.116
regulation of phosphatidylcholine biosynthetic process	GO:2001245	2	0.113
response to oxygen levels	GO:0070482	62	0.103
atp metabolic process	GO:0046034	75	0.099
apoptotic mitochondrial changes	GO:0008637	48	0.095
purine ribonucleoside monophosphate metabolic process	GO:0009167	80	0.093
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.092
generation of precursor metabolites and energy	GO:0006091	103	0.089
proteasomal ubiquitin independent protein catabolic process	GO:0010499	1	0.086
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.086
cofactor metabolic process	GO:0051186	80	0.083
positive regulation of proteolysis	GO:0045862	85	0.083
cation transmembrane transport	GO:0098655	266	0.078
age dependent response to oxidative stress	GO:0001306	3	0.077
protein maturation	GO:0051604	176	0.077
nitrogen compound transport	GO:0071705	271	0.076
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.075
protein processing	GO:0016485	163	0.075
protein modification by small protein conjugation or removal	GO:0070647	207	0.074
glycosyl compound catabolic process	GO:1901658	206	0.073
cristae formation	GO:0042407	3	0.072
ribose phosphate metabolic process	GO:0019693	291	0.070
negative regulation of cell proliferation	GO:0008285	296	0.066
protein catabolic process	GO:0030163	221	0.065
negative regulation of intrinsic apoptotic signaling pathway	GO:2001243	34	0.065
ribonucleoside metabolic process	GO:0009119	245	0.065
purine nucleotide metabolic process	GO:0006163	302	0.064
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.064
positive regulation of peptidase activity	GO:0010952	49	0.061
nucleotide metabolic process	GO:0009117	332	0.060
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.059
regulation of phospholipid biosynthetic process	GO:0071071	3	0.054
glycosyl compound metabolic process	GO:1901657	246	0.051
regulation of transferase activity	GO:0051338	263	0.051
positive regulation of apoptotic process	GO:0043065	217	0.051
protein import into nucleus	GO:0006606	95	0.050
regulation of intracellular transport	GO:0032386	159	0.050
negative regulation of intracellular signal transduction	GO:1902532	167	0.048
regulation of purine nucleotide metabolic process	GO:1900542	169	0.048
age dependent general metabolic decline	GO:0007571	3	0.048
t cell proliferation	GO:0042098	120	0.048
phosphatidylglycerol metabolic process	GO:0046471	3	0.047
purine nucleoside monophosphate metabolic process	GO:0009126	81	0.047
response to superoxide	GO:0000303	16	0.046
regulation of cysteine type endopeptidase activity	GO:2000116	65	0.045
aromatic compound catabolic process	GO:0019439	286	0.045
ribonucleotide metabolic process	GO:0009259	291	0.045
positive regulation of nucleoside metabolic process	GO:0045979	91	0.044
sulfur compound metabolic process	GO:0006790	100	0.043
spermatogenesis	GO:0007283	284	0.043
positive regulation of purine nucleotide metabolic process	GO:1900544	114	0.043
regulation of proteolysis	GO:0030162	164	0.042
neural tube formation	GO:0001841	108	0.042
guanosine containing compound metabolic process	GO:1901068	144	0.042
energy derivation by oxidation of organic compounds	GO:0015980	77	0.041
gonad development	GO:0008406	141	0.039
purine nucleoside metabolic process	GO:0042278	241	0.039
rho protein signal transduction	GO:0007266	32	0.039
ribonucleotide catabolic process	GO:0009261	208	0.038
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.038
nucleoside metabolic process	GO:0009116	246	0.038
leukocyte proliferation	GO:0070661	172	0.038
nucleoside phosphate metabolic process	GO:0006753	338	0.038
organophosphate biosynthetic process	GO:0090407	122	0.037
metal ion homeostasis	GO:0055065	189	0.037
cellular homeostasis	GO:0019725	240	0.037
reactive oxygen species metabolic process	GO:0072593	84	0.037
cellular amino acid metabolic process	GO:0006520	103	0.037
inorganic cation transmembrane transport	GO:0098662	207	0.037
ion transmembrane transport	GO:0034220	361	0.036
membrane organization	GO:0061024	245	0.035
negative regulation of phospholipid biosynthetic process	GO:0071072	1	0.035
regulation of nucleotide catabolic process	GO:0030811	122	0.035
cellular protein catabolic process	GO:0044257	155	0.034
purine nucleotide catabolic process	GO:0006195	211	0.034
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.034
extracellular structure organization	GO:0043062	148	0.034
purine ribonucleotide catabolic process	GO:0009154	208	0.033
inorganic ion transmembrane transport	GO:0098660	234	0.032
proteolysis involved in cellular protein catabolic process	GO:0051603	147	0.031
gland development	GO:0048732	330	0.031
t cell activation	GO:0042110	289	0.031
mapk cascade	GO:0000165	281	0.030
locomotory behavior	GO:0007626	195	0.030
cellular amine metabolic process	GO:0044106	44	0.029
cellular ketone metabolic process	GO:0042180	84	0.029
regulation of cellular amino acid metabolic process	GO:0006521	5	0.029
regulation of gtp catabolic process	GO:0033124	113	0.029
positive regulation of protein phosphorylation	GO:0001934	242	0.029
regulation of protein targeting	GO:1903533	61	0.029
positive regulation of cellular catabolic process	GO:0031331	148	0.028
positive regulation of transferase activity	GO:0051347	167	0.028
cation transport	GO:0006812	399	0.028
male gamete generation	GO:0048232	285	0.027
positive regulation of programmed cell death	GO:0043068	218	0.027
nucleoside catabolic process	GO:0009164	206	0.027
removal of superoxide radicals	GO:0019430	12	0.027
regulation of protein modification by small protein conjugation or removal	GO:1903320	57	0.027
regulation of cell cycle process	GO:0010564	160	0.026
ribonucleoside monophosphate metabolic process	GO:0009161	80	0.026
purine nucleoside catabolic process	GO:0006152	205	0.026
regulation of cellular amine metabolic process	GO:0033238	20	0.026
negative regulation of phosphorus metabolic process	GO:0010563	184	0.026
regulation of protein maturation	GO:1903317	96	0.026
cellular lipid metabolic process	GO:0044255	323	0.025
development of primary sexual characteristics	GO:0045137	143	0.025
oxidation reduction process	GO:0055114	342	0.025
calcium ion homeostasis	GO:0055074	127	0.025
ubiquitin dependent protein catabolic process	GO:0006511	129	0.025
regulation of organelle organization	GO:0033043	289	0.024
cytoplasmic transport	GO:0016482	234	0.024
negative regulation of alcohol biosynthetic process	GO:1902931	4	0.024
negative regulation of phosphorylation	GO:0042326	166	0.024
nucleotide catabolic process	GO:0009166	217	0.024
regulation of nucleoside metabolic process	GO:0009118	130	0.023
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	62	0.023
heterocycle catabolic process	GO:0046700	280	0.023
cellular divalent inorganic cation homeostasis	GO:0072503	127	0.023
cellular respiration	GO:0045333	38	0.023
protein import	GO:0017038	101	0.023
regulation of purine nucleotide catabolic process	GO:0033121	122	0.022
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	112	0.022
carbohydrate derivative catabolic process	GO:1901136	231	0.022
proteasomal protein catabolic process	GO:0010498	98	0.022
protein oxidation	GO:0018158	2	0.022
regulation of protein kinase activity	GO:0045859	232	0.022
cell division	GO:0051301	120	0.022
lymphocyte proliferation	GO:0046651	164	0.022
oxidoreduction coenzyme metabolic process	GO:0006733	16	0.022
regulation of endopeptidase activity	GO:0052548	89	0.022
regulation of nucleotide metabolic process	GO:0006140	169	0.022
gtp catabolic process	GO:0006184	143	0.022
negative regulation of phosphate metabolic process	GO:0045936	184	0.022
positive regulation of rna polymerase ii transcriptional preinitiation complex assembly	GO:0045899	2	0.021
cellular protein complex assembly	GO:0043623	116	0.021
amine metabolic process	GO:0009308	45	0.021
cellular response to dna damage stimulus	GO:0006974	207	0.021
positive regulation of protein modification process	GO:0031401	299	0.020
extracellular matrix organization	GO:0030198	147	0.020
divalent inorganic cation homeostasis	GO:0072507	138	0.020
ribonucleoside catabolic process	GO:0042454	206	0.020
cellular nitrogen compound catabolic process	GO:0044270	280	0.020
response to inorganic substance	GO:0010035	96	0.020
regulation of lymphocyte activation	GO:0051249	240	0.019
nucleoside triphosphate catabolic process	GO:0009143	205	0.019
ribonucleotide biosynthetic process	GO:0009260	59	0.019
epithelial tube formation	GO:0072175	130	0.019
glycerophospholipid metabolic process	GO:0006650	71	0.019
multicellular organismal aging	GO:0010259	24	0.019
primary neural tube formation	GO:0014020	95	0.019
dna metabolic process	GO:0006259	303	0.019
mitochondrial dna replication	GO:0006264	7	0.019
negative regulation of protein metabolic process	GO:0051248	282	0.018
release of cytochrome c from mitochondria	GO:0001836	23	0.018
positive regulation of cell death	GO:0010942	224	0.018
cation homeostasis	GO:0055080	212	0.018
negative regulation of cellular component organization	GO:0051129	194	0.018
blastocyst development	GO:0001824	80	0.018
positive regulation of protein complex assembly	GO:0031334	45	0.018
protein localization to organelle	GO:0033365	185	0.018
positive regulation of purine nucleotide catabolic process	GO:0033123	88	0.017
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.017
positive regulation of nucleotide catabolic process	GO:0030813	88	0.017
coenzyme biosynthetic process	GO:0009108	23	0.017
purine containing compound catabolic process	GO:0072523	213	0.017
positive regulation of protein kinase activity	GO:0045860	144	0.017
modification dependent macromolecule catabolic process	GO:0043632	133	0.017
regulation of rna polymerase ii transcriptional preinitiation complex assembly	GO:0045898	2	0.017
divalent metal ion transport	GO:0070838	172	0.017
heart morphogenesis	GO:0003007	178	0.016
regulation of reactive oxygen species metabolic process	GO:2000377	40	0.016
divalent inorganic cation transport	GO:0072511	178	0.016
regulation of cellular ketone metabolic process	GO:0010565	66	0.016
anion transport	GO:0006820	177	0.016
cellular chemical homeostasis	GO:0055082	215	0.016
regulation of protein transport	GO:0051223	163	0.015
negative regulation of organelle organization	GO:0010639	90	0.015
organic cyclic compound catabolic process	GO:1901361	295	0.015
oxygen homeostasis	GO:0032364	2	0.015
ribose phosphate biosynthetic process	GO:0046390	59	0.015
protein targeting	GO:0006605	143	0.015
tube formation	GO:0035148	140	0.015
negative regulation of proteolysis	GO:0045861	74	0.015
determination of adult lifespan	GO:0008340	11	0.015
negative regulation of sequence specific dna binding transcription factor activity	GO:0043433	40	0.015
negative regulation of protein processing	GO:0010955	79	0.015
establishment of protein localization to organelle	GO:0072594	118	0.015
cellular metal ion homeostasis	GO:0006875	151	0.015
positive regulation of nucleotide metabolic process	GO:0045981	114	0.014
immune effector process	GO:0002252	321	0.014
glycerolipid metabolic process	GO:0046486	122	0.014
regulation of protein complex assembly	GO:0043254	83	0.014
macromolecule catabolic process	GO:0009057	281	0.014
modification dependent protein catabolic process	GO:0019941	133	0.014
intracellular protein transport	GO:0006886	204	0.014
endocytosis	GO:0006897	168	0.014
organic hydroxy compound metabolic process	GO:1901615	203	0.013
morphogenesis of embryonic epithelium	GO:0016331	159	0.013
organophosphate catabolic process	GO:0046434	232	0.013
ribonucleoside monophosphate biosynthetic process	GO:0009156	9	0.013
stem cell differentiation	GO:0048863	268	0.013
peptidyl amino acid modification	GO:0018193	336	0.013
regulation of cell activation	GO:0050865	289	0.013
reactive nitrogen species metabolic process	GO:2001057	0	0.013
response to organonitrogen compound	GO:0010243	246	0.013
response to molecule of bacterial origin	GO:0002237	143	0.013
response to transforming growth factor beta	GO:0071559	88	0.013
carbohydrate derivative biosynthetic process	GO:1901137	183	0.013
regulation of mitochondrial membrane potential	GO:0051881	17	0.013
mitotic cell cycle	GO:0000278	195	0.012
dna templated transcriptional preinitiation complex assembly	GO:0070897	4	0.012
response to hyperoxia	GO:0055093	2	0.012
positive regulation of organelle organization	GO:0010638	128	0.012
exocytosis	GO:0006887	121	0.012
regulation of protein serine threonine kinase activity	GO:0071900	157	0.012
purine ribonucleoside biosynthetic process	GO:0046129	19	0.012
digestive system development	GO:0055123	200	0.012
purine ribonucleoside catabolic process	GO:0046130	205	0.012
glycerophospholipid biosynthetic process	GO:0046474	32	0.012
small gtpase mediated signal transduction	GO:0007264	97	0.012
skeletal system development	GO:0001501	356	0.011
mitotic cytokinesis	GO:0000281	4	0.011
cellular response to oxidative stress	GO:0034599	76	0.011
leukocyte mediated immunity	GO:0002443	174	0.011
positive regulation of cellular amine metabolic process	GO:0033240	5	0.011
purine nucleotide biosynthetic process	GO:0006164	65	0.011
nucleoside phosphate catabolic process	GO:1901292	222	0.011
regulation of cellular component biogenesis	GO:0044087	181	0.011
mitochondrial transport	GO:0006839	36	0.011
adult behavior	GO:0030534	135	0.011
neuron apoptotic process	GO:0051402	142	0.011
positive regulation of cell cycle	GO:0045787	92	0.011
ras protein signal transduction	GO:0007265	77	0.011
purine ribonucleotide biosynthetic process	GO:0009152	59	0.011
canonical wnt signaling pathway	GO:0060070	130	0.011
embryonic epithelial tube formation	GO:0001838	130	0.011
regulation of homeostatic process	GO:0032844	182	0.011
organonitrogen compound catabolic process	GO:1901565	264	0.010
calcium ion transport	GO:0006816	159	0.010
purine nucleoside monophosphate biosynthetic process	GO:0009127	9	0.010
organonitrogen compound biosynthetic process	GO:1901566	192	0.010
regulation of kinase activity	GO:0043549	249	0.010
negative regulation of molecular function	GO:0044092	258	0.010
regulation of protein localization	GO:0032880	231	0.010
organic acid biosynthetic process	GO:0016053	86	0.010
cellular response to lipid	GO:0071396	145	0.010
cellularization	GO:0007349	1	0.010
action potential	GO:0001508	78	0.010

Timm17a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
disease of metabolism	DOID:0014667	0.112
inherited metabolic disorder	DOID:655	0.112
immune system disease	DOID:2914	0.039
disease of anatomical entity	DOID:7	0.039
hematopoietic system disease	DOID:74	0.010
blood coagulation disease	DOID:1247	0.010

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