| proteolysis involved in cellular protein catabolic process | GO:0051603 | 147 | 0.616 | |
| modification dependent macromolecule catabolic process | GO:0043632 | 133 | 0.471 | |
| apoptotic signaling pathway | GO:0097190 | 306 | 0.315 | |
| cellular protein catabolic process | GO:0044257 | 155 | 0.313 | |
| ubiquitin dependent protein catabolic process | GO:0006511 | 129 | 0.243 | |
| modification dependent protein catabolic process | GO:0019941 | 133 | 0.222 | |
| transmembrane transport | GO:0055085 | 412 | 0.178 | |
| regulation of proteolysis involved in cellular protein catabolic process | GO:1903050 | 56 | 0.160 | |
| proteasomal protein catabolic process | GO:0010498 | 98 | 0.150 | |
| protein catabolic process | GO:0030163 | 221 | 0.146 | |
| regulation of proteasomal ubiquitin dependent protein catabolic process | GO:0032434 | 40 | 0.138 | |
| regulation of protein catabolic process | GO:0042176 | 108 | 0.119 | |
| regulation of proteasomal protein catabolic process | GO:0061136 | 46 | 0.114 | |
| cellular macromolecule catabolic process | GO:0044265 | 206 | 0.109 | |
| proteasome mediated ubiquitin dependent protein catabolic process | GO:0043161 | 88 | 0.109 | |
| macromolecule catabolic process | GO:0009057 | 281 | 0.107 | |
| regulation of cellular catabolic process | GO:0031329 | 242 | 0.103 | |
| regulation of apoptotic signaling pathway | GO:2001233 | 197 | 0.099 | |
| male gamete generation | GO:0048232 | 285 | 0.097 | |
| dna metabolic process | GO:0006259 | 303 | 0.095 | |
| negative regulation of proteasomal ubiquitin dependent protein catabolic process | GO:0032435 | 15 | 0.094 | |
| protein maturation | GO:0051604 | 176 | 0.092 | |
| negative regulation of protein metabolic process | GO:0051248 | 282 | 0.086 | |
| regulation of cellular protein catabolic process | GO:1903362 | 61 | 0.085 | |
| regulation of ion transport | GO:0043269 | 215 | 0.082 | |
| spindle assembly involved in mitosis | GO:0090307 | 4 | 0.081 | |
| heterocycle catabolic process | GO:0046700 | 280 | 0.077 | |
| regulation of protein stability | GO:0031647 | 52 | 0.076 | |
| negative regulation of molecular function | GO:0044092 | 258 | 0.075 | |
| regulation of proteolysis | GO:0030162 | 164 | 0.074 | |
| protein processing | GO:0016485 | 163 | 0.072 | |
| positive regulation of cell death | GO:0010942 | 224 | 0.066 | |
| protein modification by small protein conjugation or removal | GO:0070647 | 207 | 0.064 | |
| negative regulation of cellular catabolic process | GO:0031330 | 47 | 0.062 | |
| regulation of ion transmembrane transport | GO:0034765 | 119 | 0.061 | |
| telencephalon development | GO:0021537 | 186 | 0.056 | |
| purine ribonucleotide metabolic process | GO:0009150 | 290 | 0.056 | |
| cell fate commitment | GO:0045165 | 210 | 0.055 | |
| camera type eye development | GO:0043010 | 266 | 0.054 | |
| energy derivation by oxidation of organic compounds | GO:0015980 | 77 | 0.054 | |
| cytoplasmic microtubule organization | GO:0031122 | 14 | 0.053 | |
| negative regulation of cellular protein metabolic process | GO:0032269 | 247 | 0.052 | |
| regulation of dna binding | GO:0051101 | 39 | 0.051 | |
| actin cytoskeleton organization | GO:0030036 | 220 | 0.051 | |
| positive regulation of apoptotic process | GO:0043065 | 217 | 0.051 | |
| regulation of binding | GO:0051098 | 111 | 0.050 | |
| regulation of transmembrane transport | GO:0034762 | 128 | 0.050 | |
| regulation of cysteine type endopeptidase activity involved in apoptotic process | GO:0043281 | 62 | 0.048 | |
| fertilization | GO:0009566 | 127 | 0.047 | |
| peptidyl amino acid modification | GO:0018193 | 336 | 0.046 | |
| regulation of hydrolase activity | GO:0051336 | 246 | 0.045 | |
| positive regulation of cellular amino acid metabolic process | GO:0045764 | 3 | 0.044 | |
| regulation of membrane potential | GO:0042391 | 192 | 0.042 | |
| microtubule cytoskeleton organization | GO:0000226 | 157 | 0.042 | |
| negative regulation of proteolysis | GO:0045861 | 74 | 0.042 | |
| organelle fission | GO:0048285 | 170 | 0.040 | |
| regulation of endopeptidase activity | GO:0052548 | 89 | 0.040 | |
| purine containing compound metabolic process | GO:0072521 | 311 | 0.040 | |
| cytokinetic process | GO:0032506 | 2 | 0.038 | |
| negative regulation of protein catabolic process | GO:0042177 | 36 | 0.037 | |
| regulation of protein maturation | GO:1903317 | 96 | 0.037 | |
| negative regulation of protein maturation | GO:1903318 | 79 | 0.036 | |
| regulation of oxidative phosphorylation uncoupler activity | GO:2000275 | 3 | 0.036 | |
| regulation of transporter activity | GO:0032409 | 57 | 0.035 | |
| ketone catabolic process | GO:0042182 | 3 | 0.035 | |
| lateral inhibition | GO:0046331 | 1 | 0.034 | |
| alpha amino acid metabolic process | GO:1901605 | 59 | 0.034 | |
| oocyte construction | GO:0007308 | 2 | 0.034 | |
| forebrain development | GO:0030900 | 302 | 0.033 | |
| purine nucleotide metabolic process | GO:0006163 | 302 | 0.033 | |
| ribose phosphate metabolic process | GO:0019693 | 291 | 0.032 | |
| sperm egg recognition | GO:0035036 | 37 | 0.031 | |
| small molecule biosynthetic process | GO:0044283 | 132 | 0.029 | |
| negative regulation of ubiquitin protein transferase activity | GO:0051444 | 3 | 0.029 | |
| positive regulation of cellular amine metabolic process | GO:0033240 | 5 | 0.029 | |
| nucleotide metabolic process | GO:0009117 | 332 | 0.028 | |
| protein modification by small protein conjugation | GO:0032446 | 187 | 0.028 | |
| regulation of protein processing | GO:0070613 | 96 | 0.027 | |
| germ cell development | GO:0007281 | 185 | 0.027 | |
| divalent metal ion transport | GO:0070838 | 172 | 0.027 | |
| positive regulation of hydrolase activity | GO:0051345 | 148 | 0.026 | |
| negative regulation of protein processing | GO:0010955 | 79 | 0.026 | |
| response to oxygen levels | GO:0070482 | 62 | 0.026 | |
| negative regulation of cellular protein catabolic process | GO:1903363 | 22 | 0.026 | |
| cellular respiration | GO:0045333 | 38 | 0.025 | |
| citrate metabolic process | GO:0006101 | 3 | 0.024 | |
| regulation of cell cycle | GO:0051726 | 281 | 0.024 | |
| spermatogenesis | GO:0007283 | 284 | 0.024 | |
| mitochondrial electron transport nadh to ubiquinone | GO:0006120 | 4 | 0.024 | |
| nucleoside phosphate metabolic process | GO:0006753 | 338 | 0.023 | |
| protein refolding | GO:0042026 | 1 | 0.023 | |
| intrinsic apoptotic signaling pathway | GO:0097193 | 132 | 0.023 | |
| positive regulation of ion transport | GO:0043270 | 65 | 0.023 | |
| nuclear transport | GO:0051169 | 139 | 0.023 | |
| response to inorganic substance | GO:0010035 | 96 | 0.023 | |
| positive regulation of rna polymerase ii transcriptional preinitiation complex assembly | GO:0045899 | 2 | 0.022 | |
| negative regulation of necroptotic process | GO:0060546 | 9 | 0.022 | |
| mitotic cell cycle process | GO:1903047 | 159 | 0.022 | |
| nuclear division | GO:0000280 | 158 | 0.022 | |
| neuron apoptotic process | GO:0051402 | 142 | 0.022 | |
| positive regulation of programmed cell death | GO:0043068 | 218 | 0.021 | |
| cellularization | GO:0007349 | 1 | 0.021 | |
| membrane organization | GO:0061024 | 245 | 0.021 | |
| cellular response to dna damage stimulus | GO:0006974 | 207 | 0.021 | |
| positive regulation of purine nucleotide metabolic process | GO:1900544 | 114 | 0.021 | |
| regulation of establishment of protein localization | GO:0070201 | 181 | 0.020 | |
| mitotic cell cycle | GO:0000278 | 195 | 0.020 | |
| ion transmembrane transport | GO:0034220 | 361 | 0.020 | |
| negative regulation of phosphate metabolic process | GO:0045936 | 184 | 0.020 | |
| striated muscle tissue development | GO:0014706 | 293 | 0.020 | |
| oocyte anterior posterior axis specification | GO:0007314 | 2 | 0.019 | |
| cation transport | GO:0006812 | 399 | 0.019 | |
| purine ribonucleoside metabolic process | GO:0046128 | 241 | 0.019 | |
| ribonucleoside triphosphate metabolic process | GO:0009199 | 220 | 0.019 | |
| interleukin 8 production | GO:0032637 | 4 | 0.019 | |
| muscle tissue development | GO:0060537 | 308 | 0.019 | |
| regulation of cellular component biogenesis | GO:0044087 | 181 | 0.019 | |
| regulation of cellular amino acid metabolic process | GO:0006521 | 5 | 0.018 | |
| transcription from rna polymerase i promoter | GO:0006360 | 13 | 0.018 | |
| response to radiation | GO:0009314 | 165 | 0.018 | |
| gonad development | GO:0008406 | 141 | 0.018 | |
| monocarboxylic acid metabolic process | GO:0032787 | 191 | 0.018 | |
| hindbrain development | GO:0030902 | 128 | 0.018 | |
| organic cyclic compound catabolic process | GO:1901361 | 295 | 0.018 | |
| inorganic cation transmembrane transport | GO:0098662 | 207 | 0.018 | |
| protein localization to nucleus | GO:0034504 | 121 | 0.018 | |
| lateral ventricle development | GO:0021670 | 11 | 0.018 | |
| calcium ion transmembrane transport | GO:0070588 | 85 | 0.018 | |
| stress activated mapk cascade | GO:0051403 | 80 | 0.018 | |
| regulation of cellular amine metabolic process | GO:0033238 | 20 | 0.018 | |
| reactive oxygen species metabolic process | GO:0072593 | 84 | 0.018 | |
| spermatid differentiation | GO:0048515 | 115 | 0.017 | |
| intracellular steroid hormone receptor signaling pathway | GO:0030518 | 29 | 0.017 | |
| microtubule cytoskeleton organization involved in mitosis | GO:1902850 | 4 | 0.017 | |
| intrinsic apoptotic signaling pathway in response to osmotic stress | GO:0008627 | 2 | 0.017 | |
| carboxylic acid biosynthetic process | GO:0046394 | 86 | 0.017 | |
| cell recognition | GO:0008037 | 83 | 0.017 | |
| generation of precursor metabolites and energy | GO:0006091 | 103 | 0.017 | |
| divalent inorganic cation transport | GO:0072511 | 178 | 0.017 | |
| cation transmembrane transport | GO:0098655 | 266 | 0.017 | |
| regulation of metal ion transport | GO:0010959 | 106 | 0.017 | |
| extracellular matrix organization | GO:0030198 | 147 | 0.017 | |
| nucleobase containing small molecule metabolic process | GO:0055086 | 352 | 0.016 | |
| protein stabilization | GO:0050821 | 25 | 0.016 | |
| posttranscriptional regulation of gene expression | GO:0010608 | 155 | 0.016 | |
| neuron neuron synaptic transmission | GO:0007270 | 69 | 0.016 | |
| amine metabolic process | GO:0009308 | 45 | 0.016 | |
| ribonucleotide catabolic process | GO:0009261 | 208 | 0.016 | |
| regulation of cysteine type endopeptidase activity | GO:2000116 | 65 | 0.016 | |
| heart process | GO:0003015 | 94 | 0.016 | |
| rna polymerase ii transcriptional preinitiation complex assembly | GO:0051123 | 3 | 0.016 | |
| epithelial cell proliferation | GO:0050673 | 174 | 0.016 | |
| cell type specific apoptotic process | GO:0097285 | 268 | 0.016 | |
| leukocyte migration | GO:0050900 | 124 | 0.016 | |
| negative regulation of binding | GO:0051100 | 39 | 0.015 | |
| regulation of removal of superoxide radicals | GO:2000121 | 4 | 0.015 | |
| nitrogen compound transport | GO:0071705 | 271 | 0.015 | |
| rna splicing via endonucleolytic cleavage and ligation | GO:0000394 | 1 | 0.015 | |
| regulation of defense response | GO:0031347 | 233 | 0.015 | |
| multicellular organismal signaling | GO:0035637 | 91 | 0.015 | |
| blood circulation | GO:0008015 | 195 | 0.015 | |
| regulation of cell motility | GO:2000145 | 236 | 0.015 | |
| single fertilization | GO:0007338 | 82 | 0.015 | |
| negative regulation of protein phosphorylation | GO:0001933 | 126 | 0.015 | |
| protein folding | GO:0006457 | 28 | 0.015 | |
| calcium ion transport | GO:0006816 | 159 | 0.015 | |
| purine ribonucleoside triphosphate metabolic process | GO:0009205 | 220 | 0.015 | |
| alcohol metabolic process | GO:0006066 | 116 | 0.015 | |
| nucleocytoplasmic transport | GO:0006913 | 139 | 0.014 | |
| negative regulation of cell development | GO:0010721 | 169 | 0.014 | |
| protein ubiquitination | GO:0016567 | 171 | 0.014 | |
| actomyosin structure organization | GO:0031032 | 56 | 0.014 | |
| negative regulation of phosphorus metabolic process | GO:0010563 | 184 | 0.014 | |
| positive regulation of atpase activity | GO:0032781 | 3 | 0.014 | |
| development of primary male sexual characteristics | GO:0046546 | 88 | 0.014 | |
| regulation of protein ubiquitination | GO:0031396 | 52 | 0.014 | |
| positive regulation of cysteine type endopeptidase activity | GO:2001056 | 39 | 0.014 | |
| positive regulation of protein modification process | GO:0031401 | 299 | 0.014 | |
| response to oxygen radical | GO:0000305 | 16 | 0.014 | |
| purine nucleoside monophosphate metabolic process | GO:0009126 | 81 | 0.013 | |
| response to organonitrogen compound | GO:0010243 | 246 | 0.013 | |
| positive regulation of nucleotide metabolic process | GO:0045981 | 114 | 0.013 | |
| positive regulation of cellular component biogenesis | GO:0044089 | 94 | 0.013 | |
| histone monoubiquitination | GO:0010390 | 3 | 0.013 | |
| regulation of muscle system process | GO:0090257 | 80 | 0.013 | |
| cellular lipid metabolic process | GO:0044255 | 323 | 0.013 | |
| regulation of multi organism process | GO:0043900 | 111 | 0.013 | |
| sperm mitochondrion organization | GO:0030382 | 2 | 0.013 | |
| regulation of hormone levels | GO:0010817 | 211 | 0.013 | |
| cellular amino acid biosynthetic process | GO:0008652 | 22 | 0.013 | |
| nucleotide catabolic process | GO:0009166 | 217 | 0.013 | |
| regulation of intrinsic apoptotic signaling pathway | GO:2001242 | 61 | 0.013 | |
| determination of adult lifespan | GO:0008340 | 11 | 0.013 | |
| cartilage development | GO:0051216 | 140 | 0.013 | |
| regulation of cell activation | GO:0050865 | 289 | 0.013 | |
| response to hypoxia | GO:0001666 | 58 | 0.012 | |
| dna integrity checkpoint | GO:0031570 | 28 | 0.012 | |
| single organism nuclear import | GO:1902593 | 95 | 0.012 | |
| thioester metabolic process | GO:0035383 | 19 | 0.012 | |
| sperm individualization | GO:0007291 | 1 | 0.012 | |
| transmission of nerve impulse | GO:0019226 | 76 | 0.012 | |
| chromatin modification | GO:0016568 | 187 | 0.012 | |
| epithelial tube morphogenesis | GO:0060562 | 303 | 0.012 | |
| cell cell recognition | GO:0009988 | 44 | 0.012 | |
| regulation of cell cycle phase transition | GO:1901987 | 77 | 0.012 | |
| pallium development | GO:0021543 | 120 | 0.012 | |
| negative regulation of apoptotic signaling pathway | GO:2001234 | 104 | 0.012 | |
| organic acid biosynthetic process | GO:0016053 | 86 | 0.012 | |
| microtubule based process | GO:0007017 | 236 | 0.012 | |
| negative regulation of protein modification process | GO:0031400 | 163 | 0.012 | |
| respiratory system development | GO:0060541 | 190 | 0.012 | |
| gtp catabolic process | GO:0006184 | 143 | 0.012 | |
| genitalia development | GO:0048806 | 37 | 0.012 | |
| positive regulation of apoptotic signaling pathway | GO:2001235 | 95 | 0.012 | |
| reactive oxygen species biosynthetic process | GO:1903409 | 8 | 0.012 | |
| glycosyl compound metabolic process | GO:1901657 | 246 | 0.012 | |
| oocyte axis specification | GO:0007309 | 2 | 0.011 | |
| protein targeting | GO:0006605 | 143 | 0.011 | |
| respiratory tube development | GO:0030323 | 167 | 0.011 | |
| regulation of inflammatory response | GO:0050727 | 147 | 0.011 | |
| regulation of cell cycle process | GO:0010564 | 160 | 0.011 | |
| cellular response to oxygen radical | GO:0071450 | 14 | 0.011 | |
| mitochondrial transport | GO:0006839 | 36 | 0.011 | |
| response to peptide | GO:1901652 | 136 | 0.011 | |
| tissue homeostasis | GO:0001894 | 115 | 0.011 | |
| regulation of system process | GO:0044057 | 200 | 0.011 | |
| response to light stimulus | GO:0009416 | 135 | 0.011 | |
| protein localization to organelle | GO:0033365 | 185 | 0.011 | |
| cellular amine metabolic process | GO:0044106 | 44 | 0.011 | |
| negative regulation of immune system process | GO:0002683 | 209 | 0.011 | |
| response to growth factor | GO:0070848 | 198 | 0.011 | |
| positive regulation of transmembrane transport | GO:0034764 | 29 | 0.011 | |
| purine nucleotide catabolic process | GO:0006195 | 211 | 0.011 | |
| positive regulation of proteolysis | GO:0045862 | 85 | 0.011 | |
| neural crest cell fate commitment | GO:0014034 | 1 | 0.011 | |
| wound healing | GO:0042060 | 157 | 0.011 | |
| regulation of ion transmembrane transporter activity | GO:0032412 | 54 | 0.011 | |
| oxidation reduction process | GO:0055114 | 342 | 0.011 | |
| cellular ketone metabolic process | GO:0042180 | 84 | 0.011 | |
| fatty acid metabolic process | GO:0006631 | 121 | 0.011 | |
| regulation of reactive oxygen species metabolic process | GO:2000377 | 40 | 0.011 | |
| regulation of kinase activity | GO:0043549 | 249 | 0.011 | |
| regulation of epithelial cell proliferation | GO:0050678 | 141 | 0.011 | |
| histone modification | GO:0016570 | 159 | 0.010 | |
| endomembrane system organization | GO:0010256 | 147 | 0.010 | |
| regulation of stress activated mapk cascade | GO:0032872 | 69 | 0.010 | |
| carbohydrate derivative biosynthetic process | GO:1901137 | 183 | 0.010 | |
| regulation of cell migration | GO:0030334 | 219 | 0.010 | |
| cellular response to transforming growth factor beta stimulus | GO:0071560 | 88 | 0.010 | |
| digestive system development | GO:0055123 | 200 | 0.010 | |
| extrinsic apoptotic signaling pathway | GO:0097191 | 126 | 0.010 | |
| mitochondrion organization | GO:0007005 | 134 | 0.010 | |
| nucleoside phosphate catabolic process | GO:1901292 | 222 | 0.010 | |
| cytoplasmic transport | GO:0016482 | 234 | 0.010 | |
| negative regulation of intracellular signal transduction | GO:1902532 | 167 | 0.010 | |
| male sex differentiation | GO:0046661 | 109 | 0.010 | |
| skin development | GO:0043588 | 220 | 0.010 | |
| urogenital system development | GO:0001655 | 261 | 0.010 | |
| regulation of protein binding | GO:0043393 | 60 | 0.010 | |
