IMP: Integrative Multi-species Prediction

Mus musculus

26 known processes

Sparc

secreted acidic cysteine rich glycoprotein

(Aliases: BM-40,AA517111)

Ensembl: ENSMUSG00000018593
Entrez: 20692
UniProtKB: Q5NCU4
UniProtKB: Q5NCU5
UniProtKB: P07214

Process Predictions
Disease Predictions

Sparc biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
extracellular matrix organization	GO:0030198	147	0.896	Fly
extracellular structure organization	GO:0043062	148	0.784	Fly
regulation of proteolysis	GO:0030162	164	0.496
wound healing	GO:0042060	157	0.475	Rat
regulation of cell motility	GO:2000145	236	0.356	Human
muscle tissue development	GO:0060537	308	0.310
response to acid chemical	GO:0001101	111	0.249	Rat
protein hydroxylation	GO:0018126	4	0.235
response to organic cyclic compound	GO:0014070	198	0.235	Rat
regulation of extrinsic apoptotic signaling pathway	GO:2001236	77	0.226
cell adhesion	GO:0007155	329	0.208
cerebral cortex development	GO:0021987	86	0.199
cell matrix adhesion	GO:0007160	68	0.196
negative regulation of toll signaling pathway	GO:0045751	1	0.183
chondrocyte development	GO:0002063	24	0.182
cell substrate adhesion	GO:0031589	130	0.166
skeletal system development	GO:0001501	356	0.160
regulation of cell substrate adhesion	GO:0010810	73	0.160
response to amino acid	GO:0043200	37	0.152
negative regulation of cell migration	GO:0030336	59	0.150
inner ear morphogenesis	GO:0042472	101	0.149	Zebrafish
cardiac muscle tissue morphogenesis	GO:0055008	44	0.144
retinal blood vessel morphogenesis	GO:0061304	3	0.139
embryonic organ morphogenesis	GO:0048562	276	0.133	Zebrafish
sensory organ morphogenesis	GO:0090596	242	0.127	Zebrafish
transmission of nerve impulse	GO:0019226	76	0.122
forebrain development	GO:0030900	302	0.121
response to organonitrogen compound	GO:0010243	246	0.121	Rat
proteoglycan metabolic process	GO:0006029	38	0.121
multicellular organismal signaling	GO:0035637	91	0.118
regulation of toll signaling pathway	GO:0008592	1	0.108
long chain fatty acid import	GO:0044539	2	0.106
apoptotic signaling pathway	GO:0097190	306	0.102
regulation of phospholipid biosynthetic process	GO:0071071	3	0.099
blood vessel morphogenesis	GO:0048514	285	0.098	Human
connective tissue development	GO:0061448	179	0.093	Zebrafish
extracellular fibril organization	GO:0043206	2	0.090
response to growth factor	GO:0070848	198	0.085
rho protein signal transduction	GO:0007266	32	0.082
protein trimerization	GO:0070206	13	0.082
collagen fibril organization	GO:0030199	32	0.081
regulation of apoptotic signaling pathway	GO:2001233	197	0.080
small gtpase mediated signal transduction	GO:0007264	97	0.076
cellular response to abiotic stimulus	GO:0071214	56	0.074
insulin processing	GO:0030070	2	0.073
neutrophil apoptotic process	GO:0001781	3	0.073
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.072
protein maturation	GO:0051604	176	0.067
regulation of peptidase activity	GO:0052547	96	0.065
chondrocyte differentiation	GO:0002062	72	0.065
cartilage development involved in endochondral bone morphogenesis	GO:0060351	24	0.062
extrinsic apoptotic signaling pathway	GO:0097191	126	0.062
regulation of neutrophil apoptotic process	GO:0033029	1	0.061
glycoprotein metabolic process	GO:0009100	116	0.058
notochord development	GO:0030903	20	0.056
protein heterooligomerization	GO:0051291	14	0.055
regulation of cell adhesion	GO:0030155	154	0.054
oviduct development	GO:0060066	3	0.053
regulation of system process	GO:0044057	200	0.051
limb morphogenesis	GO:0035108	149	0.051
positive regulation of cell death	GO:0010942	224	0.051
cellular modified amino acid metabolic process	GO:0006575	63	0.049
skeletal muscle organ development	GO:0060538	163	0.048
sensory perception	GO:0007600	245	0.048
regulation of cell migration	GO:0030334	219	0.047	Human
cellular response to amino acid stimulus	GO:0071230	29	0.047
negative regulation of extrinsic apoptotic signaling pathway	GO:2001237	45	0.047
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	112	0.047
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.046
peptidyl proline hydroxylation	GO:0019511	3	0.045
neuron migration	GO:0001764	122	0.045
engulfment of apoptotic cell	GO:0043652	3	0.044
positive regulation of apoptotic process	GO:0043065	217	0.042
cardiac chamber development	GO:0003205	108	0.041
regulation of ras protein signal transduction	GO:0046578	114	0.041
membrane raft assembly	GO:0001765	3	0.040
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	GO:2001240	16	0.039
cellular response to growth factor stimulus	GO:0071363	197	0.039
heart morphogenesis	GO:0003007	178	0.039
tissue homeostasis	GO:0001894	115	0.039
cellular response to organonitrogen compound	GO:0071417	145	0.038
skeletal system morphogenesis	GO:0048705	203	0.038
camera type eye development	GO:0043010	266	0.038
fibril organization	GO:0097435	2	0.037
cellular divalent inorganic cation homeostasis	GO:0072503	127	0.036
cellular calcium ion homeostasis	GO:0006874	119	0.036
divalent inorganic cation homeostasis	GO:0072507	138	0.036
response to extracellular stimulus	GO:0009991	127	0.036	Rat
cellular response to acid chemical	GO:0071229	68	0.036
muscle cell differentiation	GO:0042692	261	0.035
cellular amino acid metabolic process	GO:0006520	103	0.035
action potential	GO:0001508	78	0.034
protein oligomerization	GO:0051259	67	0.034
appendage development	GO:0048736	166	0.034
positive regulation of ras protein signal transduction	GO:0046579	13	0.033
regulation of hydrolase activity	GO:0051336	246	0.033
fibrinolysis	GO:0042730	3	0.033
cardiac muscle tissue development	GO:0048738	130	0.033
transcription initiation from rna polymerase i promoter	GO:0006361	4	0.032
cellular component assembly involved in morphogenesis	GO:0010927	139	0.032
actin cytoskeleton organization	GO:0030036	220	0.032
cation homeostasis	GO:0055080	212	0.032
endothelial cell migration	GO:0043542	44	0.031	Human
basement membrane organization	GO:0071711	8	0.031
circulatory system process	GO:0003013	197	0.031
limb development	GO:0060173	166	0.031
cardiac ventricle morphogenesis	GO:0003208	50	0.031
ras protein signal transduction	GO:0007265	77	0.030
defense response to other organism	GO:0098542	197	0.030
limb bud formation	GO:0060174	10	0.029
cardiac chamber morphogenesis	GO:0003206	93	0.029
positive regulation of cell projection organization	GO:0031346	95	0.029
cellular amine metabolic process	GO:0044106	44	0.028
pallium development	GO:0021543	120	0.028
transmembrane transport	GO:0055085	412	0.028
regulation of extrinsic apoptotic signaling pathway in absence of ligand	GO:2001239	26	0.028
regulation of endopeptidase activity	GO:0052548	89	0.028
termination of rna polymerase i transcription	GO:0006363	2	0.027
response to inorganic substance	GO:0010035	96	0.027	Rat
cardiac muscle cell differentiation	GO:0055007	69	0.027
response to bmp	GO:0071772	14	0.027
regulation of symbiosis encompassing mutualism through parasitism	GO:0043903	52	0.026
establishment of glial blood brain barrier	GO:0060857	2	0.026
angiogenesis	GO:0001525	201	0.026	Human
retina development in camera type eye	GO:0060041	119	0.026
regulation of vesicle mediated transport	GO:0060627	139	0.026
negative regulation of molecular function	GO:0044092	258	0.025
negative regulation of cell motility	GO:2000146	61	0.025
axon ensheathment	GO:0008366	76	0.025
protein processing	GO:0016485	163	0.025
telencephalon development	GO:0021537	186	0.025
positive regulation of cell morphogenesis involved in differentiation	GO:0010770	72	0.025
regulation of multi organism process	GO:0043900	111	0.025
digestive tract development	GO:0048565	190	0.025	Fly
notochord cell differentiation	GO:0060034	1	0.024
cellular ketone metabolic process	GO:0042180	84	0.024
metal ion homeostasis	GO:0055065	189	0.024
plasma membrane organization	GO:0007009	90	0.024
signal transduction in absence of ligand	GO:0038034	55	0.023
response to peptide hormone	GO:0043434	127	0.023	Rat
negative regulation of cell development	GO:0010721	169	0.023
response to monoamine	GO:0071867	4	0.022
endochondral bone morphogenesis	GO:0060350	50	0.022
positive regulation of cellular amine metabolic process	GO:0033240	5	0.022
cellular lipid metabolic process	GO:0044255	323	0.022
multicellular organismal aging	GO:0010259	24	0.022
g1 s transition of mitotic cell cycle	GO:0000082	57	0.022
metanephric glomerular basement membrane development	GO:0072274	1	0.021
cellular response to external stimulus	GO:0071496	88	0.021
cell junction assembly	GO:0034329	52	0.021
response to oxidative stress	GO:0006979	123	0.021
protein localization to plasma membrane	GO:0072659	57	0.021
bmp signaling pathway	GO:0030509	93	0.021
cellular response to bmp stimulus	GO:0071773	14	0.021
regulation of cell cycle	GO:0051726	281	0.021
striated muscle tissue development	GO:0014706	293	0.020
regulation of tooth mineralization	GO:0070170	2	0.020
regulation of neuron projection development	GO:0010975	169	0.020
peptidyl amino acid modification	GO:0018193	336	0.020
defense response to fungus	GO:0050832	12	0.020
cardiac cell development	GO:0055006	41	0.020
membrane organization	GO:0061024	245	0.019
response to insulin	GO:0032868	100	0.019
regulation of rho protein signal transduction	GO:0035023	71	0.019
regulation of cellular amine metabolic process	GO:0033238	20	0.019
glomerular basement membrane development	GO:0032836	8	0.019
positive regulation of cell migration	GO:0030335	109	0.018	Human
monocarboxylic acid metabolic process	GO:0032787	191	0.018
oxidation reduction process	GO:0055114	342	0.018
bone development	GO:0060348	120	0.018
collagen metabolic process	GO:0032963	17	0.018
modulation by virus of host process	GO:0019054	2	0.018
regulation of phosphatidylcholine biosynthetic process	GO:2001245	2	0.018
response to transforming growth factor beta	GO:0071559	88	0.018
negative regulation of protein metabolic process	GO:0051248	282	0.017
muscle tissue morphogenesis	GO:0060415	53	0.017
cation transport	GO:0006812	399	0.017
integrin biosynthetic process	GO:0045112	1	0.017
positive regulation of programmed cell death	GO:0043068	218	0.017
calcium ion homeostasis	GO:0055074	127	0.017
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090101	61	0.016
symbiosis encompassing mutualism through parasitism	GO:0044403	83	0.016
positive regulation of peptide secretion	GO:0002793	33	0.016
regulation of angiogenesis	GO:0045765	81	0.016	Human
negative regulation of nervous system development	GO:0051961	156	0.016
defense response to bacterium	GO:0042742	119	0.016
blood circulation	GO:0008015	195	0.016
negative regulation of phagocytosis	GO:0050765	4	0.016
palate development	GO:0060021	76	0.016
regulation of blood circulation	GO:1903522	93	0.016
regeneration	GO:0031099	38	0.016
digestive tract morphogenesis	GO:0048546	147	0.016	Fly
actin polymerization or depolymerization	GO:0008154	54	0.016
lamellipodium organization	GO:0097581	29	0.016
cardiac ventricle development	GO:0003231	83	0.016
cardiac muscle cell development	GO:0055013	39	0.016
glycerophospholipid biosynthetic process	GO:0046474	32	0.016
regulation of inositol 1 4 5 trisphosphate sensitive calcium release channel activity	GO:0031585	2	0.016
head morphogenesis	GO:0060323	34	0.015
protein localization to membrane	GO:0072657	108	0.015
bone morphogenesis	GO:0060349	78	0.015
integrin mediated signaling pathway	GO:0007229	27	0.015
negative regulation of protein processing	GO:0010955	79	0.015
ossification	GO:0001503	216	0.015	Rat
lipid localization	GO:0010876	126	0.015
negative regulation of hydrolase activity	GO:0051346	71	0.015
cell type specific apoptotic process	GO:0097285	268	0.015
digestive system development	GO:0055123	200	0.015	Fly
reactive nitrogen species metabolic process	GO:2001057	0	0.015
acylglycerol metabolic process	GO:0006639	55	0.014
positive regulation of growth	GO:0045927	104	0.014	Worm
skin development	GO:0043588	220	0.014
cellular response to mechanical stimulus	GO:0071260	7	0.014
multicellular organism growth	GO:0035264	161	0.014	Worm
gastrulation	GO:0007369	116	0.014
response to nutrient levels	GO:0031667	109	0.014	Rat
cellular response to thyroid hormone stimulus	GO:0097067	1	0.014
regulation of cellular ketone metabolic process	GO:0010565	66	0.014
amine metabolic process	GO:0009308	45	0.014
negative regulation of protein activation cascade	GO:2000258	3	0.014
divalent metal ion transport	GO:0070838	172	0.014
ventricular cardiac muscle tissue morphogenesis	GO:0055010	32	0.014
cellular chemical homeostasis	GO:0055082	215	0.014
cellular ion homeostasis	GO:0006873	165	0.014
ribose phosphate metabolic process	GO:0019693	291	0.014
interspecies interaction between organisms	GO:0044419	83	0.014
actin filament polymerization	GO:0030041	44	0.014
cytoplasmic transport	GO:0016482	234	0.014
reactive oxygen species metabolic process	GO:0072593	84	0.013
cellular nitrogen compound catabolic process	GO:0044270	280	0.013
cellular metal ion homeostasis	GO:0006875	151	0.013
protein folding	GO:0006457	28	0.013
regulation of reactive oxygen species biosynthetic process	GO:1903426	2	0.013
regulation of cell cycle process	GO:0010564	160	0.013
myeloid leukocyte differentiation	GO:0002573	119	0.013
positive regulation of myeloid cell apoptotic process	GO:0033034	4	0.013
regulation of organelle organization	GO:0033043	289	0.013
regulation of map kinase activity	GO:0043405	120	0.013
cell cell junction organization	GO:0045216	72	0.013
carboxylic acid transport	GO:0046942	100	0.013
divalent inorganic cation transport	GO:0072511	178	0.013
negative regulation of cell adhesion	GO:0007162	45	0.013
negative regulation of bmp signaling pathway	GO:0030514	35	0.013
negative regulation of blood vessel morphogenesis	GO:2000181	25	0.012	Human
protein catabolic process	GO:0030163	221	0.012
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.012
substrate adhesion dependent cell spreading	GO:0034446	30	0.012
collagen biosynthetic process	GO:0032964	7	0.012
regulation of cell projection organization	GO:0031344	206	0.012
response to reactive oxygen species	GO:0000302	56	0.012
cellular response to hormone stimulus	GO:0032870	150	0.012
muscle cell development	GO:0055001	133	0.012
response to thyroid hormone	GO:0097066	2	0.012
negative regulation of proteolysis	GO:0045861	74	0.012
regulation of body fluid levels	GO:0050878	162	0.012
regulation of secretion	GO:0051046	274	0.012
organelle fission	GO:0048285	170	0.012
negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway	GO:1902176	4	0.012
chondroitin sulfate metabolic process	GO:0030204	17	0.012
positive regulation of metanephric mesenchymal cell migration	GO:2000591	1	0.012
myosin filament assembly	GO:0031034	2	0.012
response to radiation	GO:0009314	165	0.012
regulation of transferase activity	GO:0051338	263	0.012
negative regulation of tooth mineralization	GO:0070171	1	0.011
cell chemotaxis	GO:0060326	81	0.011
hair follicle morphogenesis	GO:0031069	29	0.011
cartilage development	GO:0051216	140	0.011	Zebrafish
regulation of binding	GO:0051098	111	0.011
nephron development	GO:0072006	109	0.011
single organism cell adhesion	GO:0098602	156	0.011
positive regulation of camp metabolic process	GO:0030816	19	0.011
negative regulation of peptidase activity	GO:0010466	46	0.011
spermatogenesis	GO:0007283	284	0.011
detection of chemical stimulus involved in sensory perception of taste	GO:0050912	3	0.011
positive regulation of neuron projection development	GO:0010976	79	0.011
regulation of endothelial cell apoptotic process	GO:2000351	9	0.011
vegf activated neuropilin signaling pathway involved in axon guidance	GO:1902378	1	0.011
endoderm formation	GO:0001706	20	0.011
negative regulation of neuron migration	GO:2001223	6	0.011
mapk cascade	GO:0000165	281	0.011
apical constriction	GO:0003383	4	0.011
tissue migration	GO:0090130	68	0.011	Human
regulation of protein kinase activity	GO:0045859	232	0.011
macromolecule catabolic process	GO:0009057	281	0.011
striated muscle contraction	GO:0006941	45	0.011
nucleotide metabolic process	GO:0009117	332	0.011
cellular water homeostasis	GO:0009992	2	0.011
cell growth	GO:0016049	130	0.011
t cell activation	GO:0042110	289	0.010
positive regulation of ion transport	GO:0043270	65	0.010
negative regulation of cellular component organization	GO:0051129	194	0.010
synaptic transmission	GO:0007268	329	0.010
organophosphate biosynthetic process	GO:0090407	122	0.010
regulation of metanephric mesenchymal cell migration by platelet derived growth factor receptor beta signaling pathway	GO:1900238	1	0.010
organic acid transport	GO:0015849	101	0.010
cellular protein complex assembly	GO:0043623	116	0.010
reactive oxygen species biosynthetic process	GO:1903409	8	0.010
regulation of neuron migration	GO:2001222	22	0.010
regulation of membrane potential	GO:0042391	192	0.010
i kappab kinase nf kappab signaling	GO:0007249	85	0.010
glucose homeostasis	GO:0042593	128	0.010
visual learning	GO:0008542	44	0.010
mitochondrion organization	GO:0007005	134	0.010
sphingolipid metabolic process	GO:0006665	45	0.010
positive regulation of endopeptidase activity	GO:0010950	43	0.010

Sparc disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.875
musculoskeletal system disease	DOID:17	0.875
connective tissue disease	DOID:65	0.809
bone development disease	DOID:0080006	0.739
bone disease	DOID:0080001	0.739
osteogenesis imperfecta	DOID:12347	0.521
osteochondrodysplasia	DOID:2256	0.521
nervous system disease	DOID:863	0.144
neuropathy	DOID:870	0.130
charcot marie tooth disease	DOID:10595	0.130
neuromuscular disease	DOID:440	0.130
myopathy	DOID:423	0.111
muscle tissue disease	DOID:66	0.111
muscular disease	DOID:0080000	0.111
immune system disease	DOID:2914	0.071
collagen disease	DOID:854	0.071
bone remodeling disease	DOID:0080005	0.057
bone resorption disease	DOID:0080011	0.057
osteoporosis	DOID:11476	0.057
sensory system disease	DOID:0050155	0.056
eye and adnexa disease	DOID:1492	0.056
eye disease	DOID:5614	0.056
congenital muscular dystrophy	DOID:0050557	0.050
muscular dystrophy	DOID:9884	0.050
ehlers danlos syndrome	DOID:13359	0.032
retinal disease	DOID:5679	0.022
retinal degeneration	DOID:8466	0.022
disease of metabolism	DOID:0014667	0.014
acquired metabolic disease	DOID:0060158	0.014
hypersensitivity reaction disease	DOID:0060056	0.011

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