Mus musculus

26 known processes

Sparc

secreted acidic cysteine rich glycoprotein

(Aliases: BM-40,AA517111)

Sparc biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
extracellular matrix organizationGO:00301981470.896
Fly
extracellular structure organizationGO:00430621480.784
Fly
regulation of proteolysisGO:00301621640.496
wound healingGO:00420601570.475
Rat
regulation of cell motilityGO:20001452360.356
Human
muscle tissue developmentGO:00605373080.310
response to acid chemicalGO:00011011110.249
Rat
protein hydroxylationGO:001812640.235
response to organic cyclic compoundGO:00140701980.235
Rat
regulation of extrinsic apoptotic signaling pathwayGO:2001236770.226
cell adhesionGO:00071553290.208
cerebral cortex developmentGO:0021987860.199
cell matrix adhesionGO:0007160680.196
negative regulation of toll signaling pathwayGO:004575110.183
chondrocyte developmentGO:0002063240.182
cell substrate adhesionGO:00315891300.166
skeletal system developmentGO:00015013560.160
regulation of cell substrate adhesionGO:0010810730.160
response to amino acidGO:0043200370.152
negative regulation of cell migrationGO:0030336590.150
inner ear morphogenesisGO:00424721010.149
Zebrafish
cardiac muscle tissue morphogenesisGO:0055008440.144
retinal blood vessel morphogenesisGO:006130430.139
embryonic organ morphogenesisGO:00485622760.133
Zebrafish
sensory organ morphogenesisGO:00905962420.127
Zebrafish
transmission of nerve impulseGO:0019226760.122
forebrain developmentGO:00309003020.121
response to organonitrogen compoundGO:00102432460.121
Rat
proteoglycan metabolic processGO:0006029380.121
multicellular organismal signalingGO:0035637910.118
regulation of toll signaling pathwayGO:000859210.108
long chain fatty acid importGO:004453920.106
apoptotic signaling pathwayGO:00971903060.102
regulation of phospholipid biosynthetic processGO:007107130.099
blood vessel morphogenesisGO:00485142850.098
Human
connective tissue developmentGO:00614481790.093
Zebrafish
extracellular fibril organizationGO:004320620.090
response to growth factorGO:00708481980.085
rho protein signal transductionGO:0007266320.082
protein trimerizationGO:0070206130.082
collagen fibril organizationGO:0030199320.081
regulation of apoptotic signaling pathwayGO:20012331970.080
small gtpase mediated signal transductionGO:0007264970.076
cellular response to abiotic stimulusGO:0071214560.074
insulin processingGO:003007020.073
neutrophil apoptotic processGO:000178130.073
negative regulation of apoptotic signaling pathwayGO:20012341040.072
protein maturationGO:00516041760.067
regulation of peptidase activityGO:0052547960.065
chondrocyte differentiationGO:0002062720.065
cartilage development involved in endochondral bone morphogenesisGO:0060351240.062
extrinsic apoptotic signaling pathwayGO:00971911260.062
regulation of neutrophil apoptotic processGO:003302910.061
glycoprotein metabolic processGO:00091001160.058
notochord developmentGO:0030903200.056
protein heterooligomerizationGO:0051291140.055
regulation of cell adhesionGO:00301551540.054
oviduct developmentGO:006006630.053
regulation of system processGO:00440572000.051
limb morphogenesisGO:00351081490.051
positive regulation of cell deathGO:00109422240.051
cellular modified amino acid metabolic processGO:0006575630.049
skeletal muscle organ developmentGO:00605381630.048
sensory perceptionGO:00076002450.048
regulation of cell migrationGO:00303342190.047
Human
cellular response to amino acid stimulusGO:0071230290.047
negative regulation of extrinsic apoptotic signaling pathwayGO:2001237450.047
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:00900921120.047
positive regulation of cellular amino acid metabolic processGO:004576430.046
peptidyl proline hydroxylationGO:001951130.045
neuron migrationGO:00017641220.045
engulfment of apoptotic cellGO:004365230.044
positive regulation of apoptotic processGO:00430652170.042
cardiac chamber developmentGO:00032051080.041
regulation of ras protein signal transductionGO:00465781140.041
membrane raft assemblyGO:000176530.040
negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:2001240160.039
cellular response to growth factor stimulusGO:00713631970.039
heart morphogenesisGO:00030071780.039
tissue homeostasisGO:00018941150.039
cellular response to organonitrogen compoundGO:00714171450.038
skeletal system morphogenesisGO:00487052030.038
camera type eye developmentGO:00430102660.038
fibril organizationGO:009743520.037
cellular divalent inorganic cation homeostasisGO:00725031270.036
cellular calcium ion homeostasisGO:00068741190.036
divalent inorganic cation homeostasisGO:00725071380.036
response to extracellular stimulusGO:00099911270.036
Rat
cellular response to acid chemicalGO:0071229680.036
muscle cell differentiationGO:00426922610.035
cellular amino acid metabolic processGO:00065201030.035
action potentialGO:0001508780.034
protein oligomerizationGO:0051259670.034
appendage developmentGO:00487361660.034
positive regulation of ras protein signal transductionGO:0046579130.033
regulation of hydrolase activityGO:00513362460.033
fibrinolysisGO:004273030.033
cardiac muscle tissue developmentGO:00487381300.033
transcription initiation from rna polymerase i promoterGO:000636140.032
cellular component assembly involved in morphogenesisGO:00109271390.032
actin cytoskeleton organizationGO:00300362200.032
cation homeostasisGO:00550802120.032
endothelial cell migrationGO:0043542440.031
Human
basement membrane organizationGO:007171180.031
circulatory system processGO:00030131970.031
limb developmentGO:00601731660.031
cardiac ventricle morphogenesisGO:0003208500.031
ras protein signal transductionGO:0007265770.030
defense response to other organismGO:00985421970.030
limb bud formationGO:0060174100.029
cardiac chamber morphogenesisGO:0003206930.029
positive regulation of cell projection organizationGO:0031346950.029
cellular amine metabolic processGO:0044106440.028
pallium developmentGO:00215431200.028
transmembrane transportGO:00550854120.028
regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:2001239260.028
regulation of endopeptidase activityGO:0052548890.028
termination of rna polymerase i transcriptionGO:000636320.027
response to inorganic substanceGO:0010035960.027
Rat
cardiac muscle cell differentiationGO:0055007690.027
response to bmpGO:0071772140.027
regulation of symbiosis encompassing mutualism through parasitismGO:0043903520.026
establishment of glial blood brain barrierGO:006085720.026
angiogenesisGO:00015252010.026
Human
retina development in camera type eyeGO:00600411190.026
regulation of vesicle mediated transportGO:00606271390.026
negative regulation of molecular functionGO:00440922580.025
negative regulation of cell motilityGO:2000146610.025
axon ensheathmentGO:0008366760.025
protein processingGO:00164851630.025
telencephalon developmentGO:00215371860.025
positive regulation of cell morphogenesis involved in differentiationGO:0010770720.025
regulation of multi organism processGO:00439001110.025
digestive tract developmentGO:00485651900.025
Fly
notochord cell differentiationGO:006003410.024
cellular ketone metabolic processGO:0042180840.024
metal ion homeostasisGO:00550651890.024
plasma membrane organizationGO:0007009900.024
signal transduction in absence of ligandGO:0038034550.023
response to peptide hormoneGO:00434341270.023
Rat
negative regulation of cell developmentGO:00107211690.023
response to monoamineGO:007186740.022
endochondral bone morphogenesisGO:0060350500.022
positive regulation of cellular amine metabolic processGO:003324050.022
cellular lipid metabolic processGO:00442553230.022
multicellular organismal agingGO:0010259240.022
g1 s transition of mitotic cell cycleGO:0000082570.022
metanephric glomerular basement membrane developmentGO:007227410.021
cellular response to external stimulusGO:0071496880.021
cell junction assemblyGO:0034329520.021
response to oxidative stressGO:00069791230.021
protein localization to plasma membraneGO:0072659570.021
bmp signaling pathwayGO:0030509930.021
cellular response to bmp stimulusGO:0071773140.021
regulation of cell cycleGO:00517262810.021
striated muscle tissue developmentGO:00147062930.020
regulation of tooth mineralizationGO:007017020.020
regulation of neuron projection developmentGO:00109751690.020
peptidyl amino acid modificationGO:00181933360.020
defense response to fungusGO:0050832120.020
cardiac cell developmentGO:0055006410.020
membrane organizationGO:00610242450.019
response to insulinGO:00328681000.019
regulation of rho protein signal transductionGO:0035023710.019
regulation of cellular amine metabolic processGO:0033238200.019
glomerular basement membrane developmentGO:003283680.019
positive regulation of cell migrationGO:00303351090.018
Human
monocarboxylic acid metabolic processGO:00327871910.018
oxidation reduction processGO:00551143420.018
bone developmentGO:00603481200.018
collagen metabolic processGO:0032963170.018
modulation by virus of host processGO:001905420.018
regulation of phosphatidylcholine biosynthetic processGO:200124520.018
response to transforming growth factor betaGO:0071559880.018
negative regulation of protein metabolic processGO:00512482820.017
muscle tissue morphogenesisGO:0060415530.017
cation transportGO:00068123990.017
integrin biosynthetic processGO:004511210.017
positive regulation of programmed cell deathGO:00430682180.017
calcium ion homeostasisGO:00550741270.017
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090101610.016
symbiosis encompassing mutualism through parasitismGO:0044403830.016
positive regulation of peptide secretionGO:0002793330.016
regulation of angiogenesisGO:0045765810.016
Human
negative regulation of nervous system developmentGO:00519611560.016
defense response to bacteriumGO:00427421190.016
blood circulationGO:00080151950.016
negative regulation of phagocytosisGO:005076540.016
palate developmentGO:0060021760.016
regulation of blood circulationGO:1903522930.016
regenerationGO:0031099380.016
digestive tract morphogenesisGO:00485461470.016
Fly
actin polymerization or depolymerizationGO:0008154540.016
lamellipodium organizationGO:0097581290.016
cardiac ventricle developmentGO:0003231830.016
cardiac muscle cell developmentGO:0055013390.016
glycerophospholipid biosynthetic processGO:0046474320.016
regulation of inositol 1 4 5 trisphosphate sensitive calcium release channel activityGO:003158520.016
head morphogenesisGO:0060323340.015
protein localization to membraneGO:00726571080.015
bone morphogenesisGO:0060349780.015
integrin mediated signaling pathwayGO:0007229270.015
negative regulation of protein processingGO:0010955790.015
ossificationGO:00015032160.015
Rat
lipid localizationGO:00108761260.015
negative regulation of hydrolase activityGO:0051346710.015
cell type specific apoptotic processGO:00972852680.015
digestive system developmentGO:00551232000.015
Fly
reactive nitrogen species metabolic processGO:200105700.015
acylglycerol metabolic processGO:0006639550.014
positive regulation of growthGO:00459271040.014
Worm
skin developmentGO:00435882200.014
cellular response to mechanical stimulusGO:007126070.014
multicellular organism growthGO:00352641610.014
Worm
gastrulationGO:00073691160.014
response to nutrient levelsGO:00316671090.014
Rat
cellular response to thyroid hormone stimulusGO:009706710.014
regulation of cellular ketone metabolic processGO:0010565660.014
amine metabolic processGO:0009308450.014
negative regulation of protein activation cascadeGO:200025830.014
divalent metal ion transportGO:00708381720.014
ventricular cardiac muscle tissue morphogenesisGO:0055010320.014
cellular chemical homeostasisGO:00550822150.014
cellular ion homeostasisGO:00068731650.014
ribose phosphate metabolic processGO:00196932910.014
interspecies interaction between organismsGO:0044419830.014
actin filament polymerizationGO:0030041440.014
cytoplasmic transportGO:00164822340.014
reactive oxygen species metabolic processGO:0072593840.013
cellular nitrogen compound catabolic processGO:00442702800.013
cellular metal ion homeostasisGO:00068751510.013
protein foldingGO:0006457280.013
regulation of reactive oxygen species biosynthetic processGO:190342620.013
regulation of cell cycle processGO:00105641600.013
myeloid leukocyte differentiationGO:00025731190.013
positive regulation of myeloid cell apoptotic processGO:003303440.013
regulation of organelle organizationGO:00330432890.013
regulation of map kinase activityGO:00434051200.013
cell cell junction organizationGO:0045216720.013
carboxylic acid transportGO:00469421000.013
divalent inorganic cation transportGO:00725111780.013
negative regulation of cell adhesionGO:0007162450.013
negative regulation of bmp signaling pathwayGO:0030514350.013
negative regulation of blood vessel morphogenesisGO:2000181250.012
Human
protein catabolic processGO:00301632210.012
purine nucleoside triphosphate catabolic processGO:00091462030.012
substrate adhesion dependent cell spreadingGO:0034446300.012
collagen biosynthetic processGO:003296470.012
regulation of cell projection organizationGO:00313442060.012
response to reactive oxygen speciesGO:0000302560.012
cellular response to hormone stimulusGO:00328701500.012
muscle cell developmentGO:00550011330.012
response to thyroid hormoneGO:009706620.012
negative regulation of proteolysisGO:0045861740.012
regulation of body fluid levelsGO:00508781620.012
regulation of secretionGO:00510462740.012
organelle fissionGO:00482851700.012
negative regulation of oxidative stress induced intrinsic apoptotic signaling pathwayGO:190217640.012
chondroitin sulfate metabolic processGO:0030204170.012
positive regulation of metanephric mesenchymal cell migrationGO:200059110.012
myosin filament assemblyGO:003103420.012
response to radiationGO:00093141650.012
regulation of transferase activityGO:00513382630.012
negative regulation of tooth mineralizationGO:007017110.011
cell chemotaxisGO:0060326810.011
hair follicle morphogenesisGO:0031069290.011
cartilage developmentGO:00512161400.011
Zebrafish
regulation of bindingGO:00510981110.011
nephron developmentGO:00720061090.011
single organism cell adhesionGO:00986021560.011
positive regulation of camp metabolic processGO:0030816190.011
negative regulation of peptidase activityGO:0010466460.011
spermatogenesisGO:00072832840.011
detection of chemical stimulus involved in sensory perception of tasteGO:005091230.011
positive regulation of neuron projection developmentGO:0010976790.011
regulation of endothelial cell apoptotic processGO:200035190.011
vegf activated neuropilin signaling pathway involved in axon guidanceGO:190237810.011
endoderm formationGO:0001706200.011
negative regulation of neuron migrationGO:200122360.011
mapk cascadeGO:00001652810.011
apical constrictionGO:000338340.011
tissue migrationGO:0090130680.011
Human
regulation of protein kinase activityGO:00458592320.011
macromolecule catabolic processGO:00090572810.011
striated muscle contractionGO:0006941450.011
nucleotide metabolic processGO:00091173320.011
cellular water homeostasisGO:000999220.011
cell growthGO:00160491300.011
t cell activationGO:00421102890.010
positive regulation of ion transportGO:0043270650.010
negative regulation of cellular component organizationGO:00511291940.010
synaptic transmissionGO:00072683290.010
organophosphate biosynthetic processGO:00904071220.010
regulation of metanephric mesenchymal cell migration by platelet derived growth factor receptor beta signaling pathwayGO:190023810.010
organic acid transportGO:00158491010.010
cellular protein complex assemblyGO:00436231160.010
reactive oxygen species biosynthetic processGO:190340980.010
regulation of neuron migrationGO:2001222220.010
regulation of membrane potentialGO:00423911920.010
i kappab kinase nf kappab signalingGO:0007249850.010
glucose homeostasisGO:00425931280.010
visual learningGO:0008542440.010
mitochondrion organizationGO:00070051340.010
sphingolipid metabolic processGO:0006665450.010
positive regulation of endopeptidase activityGO:0010950430.010

Sparc disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.875
musculoskeletal system diseaseDOID:1700.875
connective tissue diseaseDOID:6500.809
bone development diseaseDOID:008000600.739
bone diseaseDOID:008000100.739
osteogenesis imperfectaDOID:1234700.521
osteochondrodysplasiaDOID:225600.521
nervous system diseaseDOID:86300.144
neuropathyDOID:87000.130
charcot marie tooth diseaseDOID:1059500.130
neuromuscular diseaseDOID:44000.130
myopathyDOID:42300.111
muscle tissue diseaseDOID:6600.111
muscular diseaseDOID:008000000.111
immune system diseaseDOID:291400.071
collagen diseaseDOID:85400.071
bone remodeling diseaseDOID:008000500.057
bone resorption diseaseDOID:008001100.057
osteoporosisDOID:1147600.057
sensory system diseaseDOID:005015500.056
eye and adnexa diseaseDOID:149200.056
eye diseaseDOID:561400.056
congenital muscular dystrophyDOID:005055700.050
muscular dystrophyDOID:988400.050
ehlers danlos syndromeDOID:1335900.032
retinal diseaseDOID:567900.022
retinal degenerationDOID:846600.022
disease of metabolismDOID:001466700.014
acquired metabolic diseaseDOID:006015800.014
hypersensitivity reaction diseaseDOID:006005600.011