IMP: Integrative Multi-species Prediction

Mus musculus

196 known processes

Nkx3-1

NK-3 transcription factor, locus 1 (Drosophila)

(Aliases: bagpipe,NKX3A,Nkx-3.1,Bax,NKX3.1)

Entrez: 18095
Ensembl: ENSMUSG00000022061
UniProtKB: Q3UVH8
UniProtKB: P97436

Process Predictions
Disease Predictions

Nkx3-1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
embryonic organ morphogenesis	GO:0048562	276	0.658	Mouse
gland development	GO:0048732	330	0.618
urogenital system development	GO:0001655	261	0.592
cell adhesion	GO:0007155	329	0.518
mesenchyme development	GO:0060485	152	0.504
sensory organ morphogenesis	GO:0090596	242	0.501	Mouse
regulation of kinase activity	GO:0043549	249	0.496	Human
regulation of cellular amine metabolic process	GO:0033238	20	0.455
muscle system process	GO:0003012	141	0.447
bmp signaling pathway	GO:0030509	93	0.440
nuclear import	GO:0051170	95	0.409
angiogenesis	GO:0001525	201	0.406
mitotic chromosome condensation	GO:0007076	1	0.382
response to oxygen levels	GO:0070482	62	0.375	Human
establishment of protein localization to organelle	GO:0072594	118	0.375
locomotory behavior	GO:0007626	195	0.367
regionalization	GO:0003002	337	0.365
heart morphogenesis	GO:0003007	178	0.351
nephron tubule morphogenesis	GO:0072078	68	0.350
muscle cell differentiation	GO:0042692	261	0.332
embryonic skeletal system morphogenesis	GO:0048704	91	0.320
amine metabolic process	GO:0009308	45	0.298
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.294
regulation of establishment of protein localization	GO:0070201	181	0.293
mesenchymal cell development	GO:0014031	93	0.275
neural crest cell development	GO:0014032	48	0.258
forebrain development	GO:0030900	302	0.256	Mouse
nucleotide biosynthetic process	GO:0009165	78	0.248
axonogenesis	GO:0007409	274	0.241
neuron projection guidance	GO:0097485	141	0.240
stem cell development	GO:0048864	219	0.240
limb morphogenesis	GO:0035108	149	0.239	Mouse
nephron tubule development	GO:0072080	84	0.237
cellular ketone metabolic process	GO:0042180	84	0.235
morphogenesis of a branching structure	GO:0001763	203	0.232
response to decreased oxygen levels	GO:0036293	59	0.228	Human
epithelial tube morphogenesis	GO:0060562	303	0.223
leukocyte differentiation	GO:0002521	342	0.211
mapk cascade	GO:0000165	281	0.209
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	112	0.208
negative regulation of immune system process	GO:0002683	209	0.206
epithelial cell morphogenesis	GO:0003382	41	0.204
cell type specific apoptotic process	GO:0097285	268	0.197	Mouse
mesenchymal cell differentiation	GO:0048762	107	0.196
steroid metabolic process	GO:0008202	119	0.195
t cell activation	GO:0042110	289	0.194
cell proliferation in hindbrain	GO:0021534	10	0.192
protein localization to organelle	GO:0033365	185	0.190
regulation of mapk cascade	GO:0043408	248	0.189
synaptic transmission	GO:0007268	329	0.187
regulation of protein transport	GO:0051223	163	0.184
apoptotic signaling pathway	GO:0097190	306	0.182	Human
cellular amine metabolic process	GO:0044106	44	0.181
epithelial cell proliferation	GO:0050673	174	0.179
response to acid chemical	GO:0001101	111	0.177
camera type eye development	GO:0043010	266	0.177
development of primary sexual characteristics	GO:0045137	143	0.176
positive regulation of mapk cascade	GO:0043410	170	0.173
prostate gland development	GO:0030850	48	0.173
skin development	GO:0043588	220	0.173
organic hydroxy compound metabolic process	GO:1901615	203	0.173
stem cell differentiation	GO:0048863	268	0.172
renal tubule development	GO:0061326	87	0.172
ribonucleotide metabolic process	GO:0009259	291	0.171
regulation of anatomical structure size	GO:0090066	178	0.167
male sex differentiation	GO:0046661	109	0.165
cytoplasmic transport	GO:0016482	234	0.164
nuclear transport	GO:0051169	139	0.164
intracellular protein transport	GO:0006886	204	0.163
fertilization	GO:0009566	127	0.163
cytokine production	GO:0001816	319	0.153
neural tube development	GO:0021915	160	0.152
nephron morphogenesis	GO:0072028	69	0.151
ear morphogenesis	GO:0042471	118	0.150	Mouse
retina development in camera type eye	GO:0060041	119	0.150
mesonephric tubule morphogenesis	GO:0072171	63	0.148
generation of ovulation cycle rhythm	GO:0060112	1	0.147
positive regulation of cell cycle	GO:0045787	92	0.147	Human
circulatory system process	GO:0003013	197	0.147
multi multicellular organism process	GO:0044706	109	0.146
ureteric bud morphogenesis	GO:0060675	62	0.144
renal tubule morphogenesis	GO:0061333	72	0.143
cellular response to growth factor stimulus	GO:0071363	197	0.141
single fertilization	GO:0007338	82	0.141
nephron epithelium morphogenesis	GO:0072088	68	0.140
gonad development	GO:0008406	141	0.140
response to hypoxia	GO:0001666	58	0.140	Human
oxidation reduction process	GO:0055114	342	0.139
negative regulation of nervous system development	GO:0051961	156	0.139	Mouse
male gamete generation	GO:0048232	285	0.138
regulation of organ morphogenesis	GO:2000027	144	0.138
skeletal system development	GO:0001501	356	0.138	Mouse
kidney development	GO:0001822	213	0.138
regulation of nucleocytoplasmic transport	GO:0046822	73	0.135
regulation of hormone levels	GO:0010817	211	0.134	Human
protein localization to nucleus	GO:0034504	121	0.134
regulation of cytokine production	GO:0001817	266	0.133
hepaticobiliary system development	GO:0061008	67	0.133
endocrine process	GO:0050886	39	0.133	Human
spermatogenesis	GO:0007283	284	0.132
negative regulation of cell proliferation	GO:0008285	296	0.132
pallium development	GO:0021543	120	0.132	Mouse
regulation of cellular response to growth factor stimulus	GO:0090287	82	0.130
embryonic skeletal system development	GO:0048706	120	0.129	Mouse
regulation of secretion by cell	GO:1903530	249	0.128	Human
sensory perception	GO:0007600	245	0.127
regulation of protein kinase activity	GO:0045859	232	0.125	Human
membrane organization	GO:0061024	245	0.125
regulation of blood pressure	GO:0008217	93	0.124
single organism nuclear import	GO:1902593	95	0.124
cellular amino acid metabolic process	GO:0006520	103	0.123
telencephalon development	GO:0021537	186	0.123	Mouse
skeletal system morphogenesis	GO:0048705	203	0.122
liver development	GO:0001889	66	0.119
positive regulation of secretion by cell	GO:1903532	114	0.117	Human
regulation of systemic arterial blood pressure	GO:0003073	61	0.117
regulation of protein targeting	GO:1903533	61	0.117
developmental growth involved in morphogenesis	GO:0060560	138	0.115
positive regulation of protein modification process	GO:0031401	299	0.115	Human
nitrogen compound transport	GO:0071705	271	0.115
regulation of transcription from rna polymerase iii promoter	GO:0006359	2	0.113
negative regulation of molecular function	GO:0044092	258	0.112	Human
regulation of cellular amino acid metabolic process	GO:0006521	5	0.111
response to growth factor	GO:0070848	198	0.110
embryonic appendage morphogenesis	GO:0035113	126	0.110	Mouse
ear development	GO:0043583	200	0.110	Mouse
regulation of organelle organization	GO:0033043	289	0.108
odontogenesis	GO:0042476	78	0.108	Mouse
extracellular structure organization	GO:0043062	148	0.108
epithelial cell development	GO:0002064	159	0.107
hormone secretion	GO:0046879	128	0.107	Human
neuron migration	GO:0001764	122	0.106
wound healing	GO:0042060	157	0.106
regulation of cyclic nucleotide biosynthetic process	GO:0030802	31	0.106
protein import into nucleus	GO:0006606	95	0.104
rhythmic process	GO:0048511	174	0.102
appendage morphogenesis	GO:0035107	149	0.101	Mouse
macromolecule catabolic process	GO:0009057	281	0.099
regulation of cell motility	GO:2000145	236	0.099
negative regulation of cell development	GO:0010721	169	0.099	Mouse
cellular lipid metabolic process	GO:0044255	323	0.099
immune effector process	GO:0002252	321	0.099
protein targeting	GO:0006605	143	0.098
regulation of hormone secretion	GO:0046883	88	0.097	Human
circadian rhythm	GO:0007623	114	0.096
paraxial mesodermal cell fate commitment	GO:0048343	2	0.096
regulation of membrane potential	GO:0042391	192	0.095
morphogenesis of a branching epithelium	GO:0061138	193	0.095
organelle fission	GO:0048285	170	0.095
peptide transport	GO:0015833	133	0.094
midgut development	GO:0007494	4	0.094
regulation of protein localization to nucleus	GO:1900180	60	0.094
erk1 and erk2 cascade	GO:0070371	77	0.093
cardiac chamber morphogenesis	GO:0003206	93	0.092
sensory perception of sound	GO:0007605	97	0.092
mesonephric tubule development	GO:0072164	94	0.091
regulation of bmp signaling pathway	GO:0030510	60	0.091
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.091
mesonephric epithelium development	GO:0072163	94	0.090
central nervous system neuron differentiation	GO:0021953	162	0.090	Mouse
mesoderm morphogenesis	GO:0048332	64	0.090
multicellular organismal homeostasis	GO:0048871	164	0.090
carbon catabolite repression of transcription from rna polymerase ii promoter	GO:0000437	1	0.089
nephron development	GO:0072006	109	0.089
cation homeostasis	GO:0055080	212	0.089
gabaergic neuron differentiation	GO:0097154	11	0.088	Mouse
developmental maturation	GO:0021700	193	0.088
gastrulation	GO:0007369	116	0.087
lymphocyte differentiation	GO:0030098	242	0.086
nucleobase containing small molecule metabolic process	GO:0055086	352	0.086
coagulation	GO:0050817	78	0.086
canonical wnt signaling pathway	GO:0060070	130	0.085
epithelial mesenchymal signaling involved in prostate gland development	GO:0060738	2	0.085
carbohydrate derivative biosynthetic process	GO:1901137	183	0.082
lymphocyte mediated immunity	GO:0002449	139	0.082
digestive tract development	GO:0048565	190	0.082
transmembrane transport	GO:0055085	412	0.082
organophosphate biosynthetic process	GO:0090407	122	0.081
regulation of transferase activity	GO:0051338	263	0.081	Human
positive regulation of kidney development	GO:0090184	28	0.081
regulation of hydrolase activity	GO:0051336	246	0.081	Human
mitotic cell cycle process	GO:1903047	159	0.080
regulation of cyclic nucleotide metabolic process	GO:0030799	40	0.079
astrocyte differentiation	GO:0048708	43	0.079
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.079
nucleocytoplasmic transport	GO:0006913	139	0.079
appendage development	GO:0048736	166	0.078	Mouse
mesonephros development	GO:0001823	97	0.078
purine containing compound biosynthetic process	GO:0072522	70	0.078
ion transmembrane transport	GO:0034220	361	0.077
regulation of intracellular transport	GO:0032386	159	0.077
development of primary male sexual characteristics	GO:0046546	88	0.076
single organism cell adhesion	GO:0098602	156	0.076
anion transport	GO:0006820	177	0.076
muscle tissue development	GO:0060537	308	0.076
branching involved in ureteric bud morphogenesis	GO:0001658	56	0.075
kidney epithelium development	GO:0072073	121	0.074
monocarboxylic acid metabolic process	GO:0032787	191	0.074
regulation of cell cycle	GO:0051726	281	0.074	Human
cyclic nucleotide biosynthetic process	GO:0009190	44	0.074
heart growth	GO:0060419	45	0.073
regulation of protein localization	GO:0032880	231	0.073
dna metabolic process	GO:0006259	303	0.073
positive regulation of apoptotic signaling pathway	GO:2001235	95	0.073	Human
purine nucleotide biosynthetic process	GO:0006164	65	0.073
regulation of smooth muscle contraction	GO:0006940	22	0.072
regulation of purine nucleotide biosynthetic process	GO:1900371	34	0.071
regulation of apoptotic signaling pathway	GO:2001233	197	0.071	Human
cation transmembrane transport	GO:0098655	266	0.071
positive regulation of programmed cell death	GO:0043068	218	0.070	Human
multicellular organism growth	GO:0035264	161	0.070
placenta development	GO:0001890	140	0.070
mitotic cell cycle	GO:0000278	195	0.069	Human
regulation of cellular component biogenesis	GO:0044087	181	0.068
engulfment of apoptotic cell	GO:0043652	3	0.068
morphogenesis of embryonic epithelium	GO:0016331	159	0.067
single organismal cell cell adhesion	GO:0016337	131	0.067
carboxylic acid transport	GO:0046942	100	0.067
response to oxidative stress	GO:0006979	123	0.067
fat cell differentiation	GO:0045444	160	0.066
cerebral cortex neuron differentiation	GO:0021895	19	0.066	Mouse
paraxial mesodermal cell differentiation	GO:0048342	2	0.066
response to radiation	GO:0009314	165	0.066
outflow tract morphogenesis	GO:0003151	53	0.066
ossification	GO:0001503	216	0.065
sulfur compound metabolic process	GO:0006790	100	0.064
regulation of tube size	GO:0035150	57	0.064
cyclic purine nucleotide metabolic process	GO:0052652	43	0.064
blood vessel morphogenesis	GO:0048514	285	0.063
positive regulation of cytoplasmic transport	GO:1903651	40	0.063
regulation of nucleotide biosynthetic process	GO:0030808	34	0.063
head morphogenesis	GO:0060323	34	0.063
carbohydrate transport	GO:0008643	62	0.062
protein import	GO:0017038	101	0.062
cartilage development	GO:0051216	140	0.062
adult locomotory behavior	GO:0008344	91	0.062
regulation of protein import into nucleus	GO:0042306	52	0.061
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090101	61	0.061
positive regulation of cellular amine metabolic process	GO:0033240	5	0.060
mitochondrion organization	GO:0007005	134	0.060
chondrocyte differentiation	GO:0002062	72	0.060
muscle contraction	GO:0006936	101	0.060
limb development	GO:0060173	166	0.060	Mouse
organonitrogen compound biosynthetic process	GO:1901566	192	0.060
skeletal muscle organ development	GO:0060538	163	0.059
mesoderm formation	GO:0001707	62	0.059
digestive system development	GO:0055123	200	0.059
regulation of protein serine threonine kinase activity	GO:0071900	157	0.058
positive regulation of cell division	GO:0051781	31	0.058	Human
regulation of systemic arterial blood pressure mediated by a chemical signal	GO:0003044	33	0.058
negative regulation of hydrolase activity	GO:0051346	71	0.058
regulation of cellular ketone metabolic process	GO:0010565	66	0.058
glial cell differentiation	GO:0010001	131	0.058	Mouse
neuron apoptotic process	GO:0051402	142	0.057	Mouse
neuron maturation	GO:0042551	29	0.056
embryonic epithelial tube formation	GO:0001838	130	0.056
carbon catabolite activation of transcription from rna polymerase ii promoter	GO:0000436	4	0.056
kidney morphogenesis	GO:0060993	83	0.056
spinal cord motor neuron differentiation	GO:0021522	35	0.055
camp biosynthetic process	GO:0006171	31	0.055
activation of transmembrane receptor protein tyrosine kinase activity	GO:0007171	3	0.055
nephron epithelium development	GO:0072009	92	0.055
extracellular matrix organization	GO:0030198	147	0.055
positive regulation of intracellular transport	GO:0032388	70	0.055
ribonucleoside metabolic process	GO:0009119	245	0.055
palate development	GO:0060021	76	0.054	Mouse
camp metabolic process	GO:0046058	40	0.054
regulation of stem cell differentiation	GO:2000736	50	0.054
cellular response to cytokine stimulus	GO:0071345	189	0.054	Human
homeostasis of number of cells	GO:0048872	210	0.054
regulation of camp metabolic process	GO:0030814	30	0.053
positive regulation of transcription from rna polymerase iii promoter	GO:0045945	1	0.053
organic hydroxy compound biosynthetic process	GO:1901617	77	0.053
adult behavior	GO:0030534	135	0.053
negative regulation of canonical wnt signaling pathway	GO:0090090	51	0.053
striated muscle cell proliferation	GO:0014855	39	0.052
cofactor metabolic process	GO:0051186	80	0.052
purine ribonucleotide biosynthetic process	GO:0009152	59	0.052
nucleoside phosphate biosynthetic process	GO:1901293	79	0.051
response to organonitrogen compound	GO:0010243	246	0.051
regulation of nucleotide metabolic process	GO:0006140	169	0.051
regulation of embryonic development	GO:0045995	71	0.050
negative regulation of protein metabolic process	GO:0051248	282	0.050
epithelial to mesenchymal transition	GO:0001837	47	0.050
cell maturation	GO:0048469	127	0.050
regulation of cellular catabolic process	GO:0031329	242	0.050
regulation of cysteine type endopeptidase activity	GO:2000116	65	0.050	Human
primary prostatic bud elongation	GO:0060516	2	0.049
spinal cord motor neuron cell fate specification	GO:0021520	13	0.049
cell differentiation involved in embryonic placenta development	GO:0060706	26	0.049
regulation of transcription factor import into nucleus	GO:0042990	24	0.049
regulation of protein complex assembly	GO:0043254	83	0.049
cell activation involved in immune response	GO:0002263	126	0.048
leydig cell differentiation	GO:0033327	10	0.048
regulation of proteolysis	GO:0030162	164	0.048	Human
muscle cell proliferation	GO:0033002	52	0.048
regulation of cell adhesion	GO:0030155	154	0.048
regulation of vasculature development	GO:1901342	88	0.048
bone development	GO:0060348	120	0.047
mating	GO:0007618	27	0.047
organic acid transport	GO:0015849	101	0.047
intrinsic apoptotic signaling pathway by p53 class mediator	GO:0072332	35	0.046
negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis	GO:0072040	4	0.046
intrinsic apoptotic signaling pathway	GO:0097193	132	0.045	Human
ribose phosphate biosynthetic process	GO:0046390	59	0.045
regulation of angiogenesis	GO:0045765	81	0.045
endodermal cell fate specification	GO:0001714	4	0.045
inflammatory response	GO:0006954	244	0.045
positive regulation of cell death	GO:0010942	224	0.044	Human
axial mesoderm formation	GO:0048320	3	0.044
neural tube patterning	GO:0021532	43	0.044
cellular response to dna damage stimulus	GO:0006974	207	0.044	Human
phenol containing compound metabolic process	GO:0018958	60	0.044
inner ear receptor cell differentiation	GO:0060113	61	0.043
positive regulation of transferase activity	GO:0051347	167	0.043	Human
positive regulation of epithelial cell proliferation	GO:0050679	68	0.043	Mouse
histamine induced gastric acid secretion	GO:0001697	1	0.043
cellular response to gonadotropin stimulus	GO:0071371	4	0.043
regulation of organ growth	GO:0046620	61	0.043
wnt signaling pathway	GO:0016055	188	0.043
vasodilation by norepinephrine epinephrine involved in regulation of systemic arterial blood pressure	GO:0002025	3	0.043
response to organic cyclic compound	GO:0014070	198	0.043
gliogenesis	GO:0042063	141	0.043	Mouse
secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development	GO:0060528	4	0.043
cellular response to follicle stimulating hormone stimulus	GO:0071372	1	0.043
positive regulation of protein transport	GO:0051222	93	0.042
cerebral cortex development	GO:0021987	86	0.042
regulation of neuron apoptotic process	GO:0043523	122	0.042	Mouse
myeloid cell differentiation	GO:0030099	233	0.042
neuron neuron synaptic transmission	GO:0007270	69	0.042
metanephric loop of henle development	GO:0072236	4	0.042
respiratory system development	GO:0060541	190	0.041
amide transport	GO:0042886	138	0.041
regulation of reactive oxygen species metabolic process	GO:2000377	40	0.041
regulation of cell morphogenesis involved in differentiation	GO:0010769	151	0.041
cell cycle arrest	GO:0007050	37	0.041	Human
glucose transport	GO:0015758	56	0.041
renal system process	GO:0003014	48	0.041
tissue remodeling	GO:0048771	102	0.041
pyramidal neuron migration	GO:0021852	1	0.040
carbohydrate metabolic process	GO:0005975	230	0.040
regulation of blood vessel size	GO:0050880	56	0.040
bone mineralization	GO:0030282	54	0.040
protein catabolic process	GO:0030163	221	0.040
regulation of purine nucleotide metabolic process	GO:1900542	169	0.040
regulation of blood circulation	GO:1903522	93	0.040
cell fate commitment	GO:0045165	210	0.040	Mouse
endothelium development	GO:0003158	45	0.040
negative regulation of protein processing	GO:0010955	79	0.040
response to extracellular stimulus	GO:0009991	127	0.039
protein processing	GO:0016485	163	0.039	Human
positive regulation of lymphocyte activation	GO:0051251	140	0.039
branching morphogenesis of an epithelial tube	GO:0048754	159	0.039
limbic system development	GO:0021761	72	0.039	Mouse
protein maturation	GO:0051604	176	0.039	Human
axon guidance	GO:0007411	141	0.038
reproductive behavior	GO:0019098	32	0.038
renal system development	GO:0072001	225	0.038
regulation of cartilage development	GO:0061035	44	0.038
regulation of reproductive process	GO:2000241	66	0.037
primary neural tube formation	GO:0014020	95	0.037
transcription from rna polymerase iii promoter	GO:0006383	3	0.037
septum primum development	GO:0003284	4	0.037
t cell differentiation in thymus	GO:0033077	77	0.037
regulation of defense response	GO:0031347	233	0.037
negative regulation of response to wounding	GO:1903035	77	0.037
cellular response to lipid	GO:0071396	145	0.037	Human
determination of heart left right asymmetry	GO:0061371	48	0.037
digestive tract morphogenesis	GO:0048546	147	0.036
positive regulation of nucleotide biosynthetic process	GO:0030810	26	0.036
chemotaxis	GO:0006935	247	0.036
cell migration involved in gastrulation	GO:0042074	13	0.036
regulation of muscle contraction	GO:0006937	49	0.036
positive regulation of mesonephros development	GO:0061213	20	0.036
reactive oxygen species biosynthetic process	GO:1903409	8	0.036
cell fate specification	GO:0001708	72	0.036
female sex differentiation	GO:0046660	84	0.036
neural crest cell differentiation	GO:0014033	54	0.036
cellular protein complex assembly	GO:0043623	116	0.036
divalent metal ion transport	GO:0070838	172	0.036
regulation of astrocyte differentiation	GO:0048710	20	0.036
embryonic digit morphogenesis	GO:0042733	56	0.036
skeletal muscle cell differentiation	GO:0035914	66	0.036
regulation of lymphocyte activation	GO:0051249	240	0.035
activation of adenylate cyclase activity	GO:0007190	4	0.035
ventral spinal cord development	GO:0021517	48	0.035
salivary gland morphogenesis	GO:0007435	33	0.035
blood circulation	GO:0008015	195	0.035
positive regulation of protein serine threonine kinase activity	GO:0071902	106	0.035
positive regulation of protein kinase activity	GO:0045860	144	0.035	Human
anion transmembrane transport	GO:0098656	71	0.035
regulation of intracellular protein transport	GO:0033157	82	0.035
positive regulation of bmp signaling pathway	GO:0030513	23	0.035
macromolecule methylation	GO:0043414	120	0.035
covalent chromatin modification	GO:0016569	163	0.035
body morphogenesis	GO:0010171	45	0.035
positive regulation of protein localization to nucleus	GO:1900182	30	0.035
negative regulation of cell cycle	GO:0045786	123	0.035	Human
negative regulation of neuron apoptotic process	GO:0043524	92	0.035	Mouse
cellular carbohydrate metabolic process	GO:0044262	119	0.035
ribose phosphate metabolic process	GO:0019693	291	0.034
epithelial cell maturation involved in prostate gland development	GO:0060743	4	0.034
regulation of response to wounding	GO:1903034	189	0.034
regulation of secretion	GO:0051046	274	0.034	Human
cerebral cortex gabaergic interneuron differentiation	GO:0021892	9	0.034	Mouse
endocrine hormone secretion	GO:0060986	15	0.034	Human
anatomical structure homeostasis	GO:0060249	145	0.034
cardiac ventricle morphogenesis	GO:0003208	50	0.034
positive regulation of protein phosphorylation	GO:0001934	242	0.034	Human
regulation of epithelial cell proliferation	GO:0050678	141	0.034
protein kinase b signaling	GO:0043491	74	0.034
adaptive immune response	GO:0002250	155	0.034
multi organism reproductive behavior	GO:0044705	29	0.034
nucleoside phosphate metabolic process	GO:0006753	338	0.034
response to cold	GO:0009409	19	0.034
cellular response to hormone stimulus	GO:0032870	150	0.034	Human
positive regulation of lymphocyte mediated immunity	GO:0002708	62	0.034
epidermis development	GO:0008544	187	0.034
gastrin induced gastric acid secretion	GO:0001698	1	0.034
spinal cord development	GO:0021510	81	0.034
lipid biosynthetic process	GO:0008610	179	0.034
cell matrix adhesion	GO:0007160	68	0.033
ribonucleotide biosynthetic process	GO:0009260	59	0.033
regulation of mitotic cell cycle	GO:0007346	126	0.033	Human
cytokine mediated signaling pathway	GO:0019221	115	0.033
organ growth	GO:0035265	117	0.033
smoothened signaling pathway	GO:0007224	105	0.033
glomerulus development	GO:0032835	40	0.033
glial cell development	GO:0021782	54	0.033
forelimb morphogenesis	GO:0035136	40	0.033
cardiac septum development	GO:0003279	59	0.033
cardiac muscle cell proliferation	GO:0060038	31	0.033
neural tube closure	GO:0001843	90	0.032
acid secretion	GO:0046717	33	0.032
cell proliferation involved in kidney development	GO:0072111	14	0.032
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002460	145	0.032
leukocyte homeostasis	GO:0001776	79	0.032
negative regulation of transcription from rna polymerase ii promoter by glucose	GO:0000433	1	0.032
mesodermal cell migration	GO:0008078	4	0.032
monosaccharide transport	GO:0015749	58	0.031
organelle localization	GO:0051640	179	0.031
leukocyte apoptotic process	GO:0071887	71	0.031
retina morphogenesis in camera type eye	GO:0060042	45	0.031
regulation of endopeptidase activity	GO:0052548	89	0.031	Human
segmentation	GO:0035282	93	0.031
negative regulation of proteolysis	GO:0045861	74	0.031
cellular chemical homeostasis	GO:0055082	215	0.031
purine containing compound metabolic process	GO:0072521	311	0.031
tube closure	GO:0060606	91	0.030
regulation of stem cell proliferation	GO:0072091	78	0.030
protein oligomerization	GO:0051259	67	0.030
regulation of cardiac muscle tissue growth	GO:0055021	26	0.030
eye photoreceptor cell differentiation	GO:0001754	41	0.030
regulation of glial cell differentiation	GO:0045685	41	0.030	Mouse
reactive oxygen species metabolic process	GO:0072593	84	0.030
regulation of morphogenesis of a branching structure	GO:0060688	53	0.030
regulation of heart growth	GO:0060420	31	0.029
regulation of organ formation	GO:0003156	34	0.029
pancreatic a cell fate commitment	GO:0003326	2	0.029
hippocampus development	GO:0021766	52	0.029	Mouse
regulation of feeding behavior	GO:0060259	3	0.029
histone modification	GO:0016570	159	0.029
aromatic compound catabolic process	GO:0019439	286	0.029
small molecule biosynthetic process	GO:0044283	132	0.029
negative regulation of bmp signaling pathway	GO:0030514	35	0.029
corticotropin releasing hormone secretion	GO:0043396	2	0.029
extrinsic apoptotic signaling pathway	GO:0097191	126	0.029
tissue homeostasis	GO:0001894	115	0.029
regulation of neuron death	GO:1901214	134	0.029	Mouse
cardiac ventricle development	GO:0003231	83	0.029
negative regulation of astrocyte differentiation	GO:0048712	10	0.029
regulation of mesonephros development	GO:0061217	24	0.029
muscle hypertrophy	GO:0014896	24	0.029
detection of abiotic stimulus	GO:0009582	60	0.028
regulation of cytoplasmic transport	GO:1903649	112	0.028
hindbrain development	GO:0030902	128	0.028
ventricular septum development	GO:0003281	42	0.028
regulation of mesenchymal cell proliferation involved in ureter development	GO:0072199	3	0.028
nuclear division	GO:0000280	158	0.028
protein modification by small protein conjugation	GO:0032446	187	0.028
blastocyst formation	GO:0001825	33	0.028
activation of cysteine type endopeptidase activity	GO:0097202	27	0.028	Human
granulosa cell differentiation	GO:0060014	1	0.028
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.028
embryonic eye morphogenesis	GO:0048048	29	0.028
cellular modified amino acid metabolic process	GO:0006575	63	0.028
positive regulation of nucleocytoplasmic transport	GO:0046824	30	0.028
carbohydrate homeostasis	GO:0033500	128	0.028
lymphocyte activation involved in immune response	GO:0002285	93	0.028
cardiac chamber development	GO:0003205	108	0.028
b cell mediated immunity	GO:0019724	71	0.028

Nkx3-1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
disease of cellular proliferation	DOID:14566	0.127
cancer	DOID:162	0.097
organ system cancer	DOID:0050686	0.060
sensory system disease	DOID:0050155	0.041
disease of anatomical entity	DOID:7	0.041
eye and adnexa disease	DOID:1492	0.041
nervous system disease	DOID:863	0.041
eye disease	DOID:5614	0.041

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