Mus musculus

26 known processes

Chek2

CHK2 checkpoint homolog (S. pombe)

(Aliases: Cds1,Rad53,HUCDS1,CHK2)

Chek2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
dna metabolic processGO:00062593030.597
Human Fly
cellular response to dna damage stimulusGO:00069742070.569
meiotic cell cycle processGO:1903046770.430
Worm
mitotic cell cycleGO:00002781950.342
Human Fly
mitotic chromosome condensationGO:000707610.319
dna repairGO:00062811070.317
Human Fly
microtubule cytoskeleton organizationGO:00002261570.288
Human
dna recombinationGO:0006310920.261
metaphase plate congressionGO:005131020.255
regulation of cell cycle processGO:00105641600.220
Human Fly
nuclear divisionGO:00002801580.192
Human Worm
nucleoside monophosphate metabolic processGO:0009123850.189
cellular nitrogen compound catabolic processGO:00442702800.169
nucleoside phosphate catabolic processGO:19012922220.168
purine nucleotide metabolic processGO:00061633020.167
organelle fissionGO:00482851700.164
Human Worm
meiotic nuclear divisionGO:00071261150.160
Worm
intrinsic apoptotic signaling pathwayGO:00971931320.156
Human Fly
cell divisionGO:00513011200.151
spindle assembly involved in mitosisGO:009030740.150
Human
purine ribonucleoside metabolic processGO:00461282410.150
nucleobase containing small molecule metabolic processGO:00550863520.150
regulation of cell cycleGO:00517262810.141
Human Fly
nucleotide metabolic processGO:00091173320.137
meiosis iGO:0007127600.136
organophosphate catabolic processGO:00464342320.136
macromolecule catabolic processGO:00090572810.132
Human
regulation of organelle organizationGO:00330432890.132
regulation of cellular amine metabolic processGO:0033238200.126
dna conformation changeGO:0071103370.124
double strand break repairGO:0006302480.124
Human
purine nucleoside metabolic processGO:00422782410.124
regulation of cellular catabolic processGO:00313292420.124
glycosyl compound catabolic processGO:19016582060.124
purine ribonucleotide metabolic processGO:00091502900.123
purine nucleoside triphosphate metabolic processGO:00091442260.123
ribonucleoside catabolic processGO:00424542060.121
meiotic cell cycleGO:00513211220.121
Worm
glycosyl compound metabolic processGO:19016572460.120
organic cyclic compound catabolic processGO:19013612950.120
cellular ketone metabolic processGO:0042180840.118
nucleoside catabolic processGO:00091642060.115
protein catabolic processGO:00301632210.112
Human
ribonucleoside triphosphate catabolic processGO:00092031990.111
heterocycle catabolic processGO:00467002800.109
purine ribonucleoside triphosphate metabolic processGO:00092052200.109
double strand break repair via homologous recombinationGO:0000724210.107
microtubule based processGO:00070172360.106
Human
organelle assemblyGO:00709251770.105
Human
purine containing compound metabolic processGO:00725213110.105
mitotic cell cycle processGO:19030471590.101
Human Fly
nucleotide catabolic processGO:00091662170.095
cellular amino acid metabolic processGO:00065201030.095
regulation of mitotic cell cycleGO:00073461260.095
Human Fly
ribonucleotide catabolic processGO:00092612080.095
nucleoside phosphate metabolic processGO:00067533380.094
ribonucleoside monophosphate catabolic processGO:0009158570.093
ribose phosphate metabolic processGO:00196932910.092
apoptotic signaling pathwayGO:00971903060.092
Human Fly
nucleoside triphosphate metabolic processGO:00091412300.086
positive regulation of cellular amine metabolic processGO:003324050.086
purine nucleoside triphosphate catabolic processGO:00091462030.085
amine metabolic processGO:0009308450.085
response to radiationGO:00093141650.084
cellular amine metabolic processGO:0044106440.082
purine ribonucleoside catabolic processGO:00461302050.082
aromatic compound catabolic processGO:00194392860.079
carbohydrate derivative catabolic processGO:19011362310.079
covalent chromatin modificationGO:00165691630.079
positive regulation of cellular amino acid metabolic processGO:004576430.077
negative regulation of cell cycleGO:00457861230.074
Human Fly
microtubule cytoskeleton organization involved in mitosisGO:190285040.073
Human
negative regulation of cellular component organizationGO:00511291940.072
spindle assemblyGO:0051225130.072
Human
purine containing compound catabolic processGO:00725232130.069
purine nucleotide catabolic processGO:00061952110.068
nucleoside metabolic processGO:00091162460.068
positive regulation of apoptotic processGO:00430652170.066
Fly
organonitrogen compound catabolic processGO:19015652640.066
purine nucleoside catabolic processGO:00061522050.066
purine ribonucleoside triphosphate catabolic processGO:00092071990.066
ribonucleoside triphosphate metabolic processGO:00091992200.064
ribonucleoside metabolic processGO:00091192450.063
regulation of cell divisionGO:0051302760.062
atp catabolic processGO:0006200550.062
regulation of cellular amino acid metabolic processGO:000652150.062
regulation of cellular ketone metabolic processGO:0010565660.061
ribonucleotide metabolic processGO:00092592910.061
purine ribonucleotide catabolic processGO:00091542080.060
regulation of chromosome organizationGO:0033044830.059
chromatin modificationGO:00165681870.058
regulation of mitotic cell cycle phase transitionGO:1901990730.058
Human Fly
positive regulation of protein modification processGO:00314012990.058
wnt signaling pathwayGO:00160551880.058
negative regulation of phosphorus metabolic processGO:00105631840.056
ribonucleoside monophosphate metabolic processGO:0009161800.056
purine ribonucleoside monophosphate metabolic processGO:0009167800.056
chromatin organizationGO:00063252060.056
ras protein signal transductionGO:0007265770.055
negative regulation of organelle organizationGO:0010639900.053
response to uvGO:0009411440.053
establishment of organelle localizationGO:00516561220.052
nucleoside triphosphate catabolic processGO:00091432050.052
regulation of microtubule based processGO:0032886520.052
purine nucleoside monophosphate catabolic processGO:0009128580.051
mitotic cytokinesisGO:000028140.051
recombinational repairGO:0000725210.050
microtubule organizing center organizationGO:0031023280.049
nucleoside monophosphate catabolic processGO:0009125590.049
centrosome cycleGO:0007098230.048
dna replicationGO:0006260520.048
Human
purine nucleoside monophosphate metabolic processGO:0009126810.047
cellular response to gamma radiationGO:007148040.047
Fly
regulation of protein localizationGO:00328802310.047
positive regulation of chromatin modificationGO:1903310280.047
leukocyte differentiationGO:00025213420.047
homeostasis of number of cellsGO:00488722100.046
cellular response to radiationGO:0071478280.044
Fly
negative regulation of cellular protein metabolic processGO:00322692470.044
negative regulation of phosphate metabolic processGO:00459361840.044
negative regulation of cell cycle phase transitionGO:1901988480.043
Human Fly
response to light stimulusGO:00094161350.043
regulation of cytoskeleton organizationGO:00514931220.043
histone modificationGO:00165701590.042
mitotic sister chromatid segregationGO:0000070140.041
attachment of spindle microtubules to kinetochoreGO:000860840.041
positive regulation of hydrolase activityGO:00513451480.041
Fly
negative regulation of protein metabolic processGO:00512482820.040
male meiosisGO:0007140370.040
chromosome segregationGO:0007059480.039
Worm
cell fate commitmentGO:00451652100.038
maintenance of locationGO:0051235890.038
ubiquitin dependent protein catabolic processGO:00065111290.038
small gtpase mediated signal transductionGO:0007264970.037
regulation of protein kinase activityGO:00458592320.036
regulation of transferase activityGO:00513382630.036
atp metabolic processGO:0046034750.035
cation transportGO:00068123990.035
chromosome separationGO:0051304140.034
regulation of kinase activityGO:00435492490.034
cellular response to abiotic stimulusGO:0071214560.033
Fly
oxidation reduction processGO:00551143420.033
regulation of apoptotic signaling pathwayGO:20012331970.033
myeloid cell differentiationGO:00300992330.033
anatomical structure homeostasisGO:00602491450.032
dna packagingGO:0006323300.032
dna catabolic processGO:0006308190.032
organelle localizationGO:00516401790.032
regulation of histone modificationGO:0031056560.031
positive regulation of cell cycleGO:0045787920.031
peptidyl amino acid modificationGO:00181933360.031
regulation of mitosisGO:0007088290.031
positive regulation of proteolysisGO:0045862850.030
Fly
male meiosis iGO:0007141160.030
cytokinesisGO:0000910170.029
multicellular organism growthGO:00352641610.029
positive regulation of programmed cell deathGO:00430682180.029
Fly
female gamete generationGO:0007292740.029
regulation of proteasomal protein catabolic processGO:0061136460.028
positive regulation of cellular catabolic processGO:00313311480.028
negative regulation of cell cycle processGO:0010948690.028
Human Fly
protein modification by small protein conjugation or removalGO:00706472070.028
negative regulation of intracellular signal transductionGO:19025321670.028
lymphocyte apoptotic processGO:0070227540.028
regulation of wnt signaling pathwayGO:00301111230.027
citrate metabolic processGO:000610130.027
centrosome separationGO:005129940.027
female meiosis chromosome segregationGO:001632110.027
regulation of chromatin modificationGO:1903308570.026
negative regulation of mitotic cell cycleGO:0045930580.026
Human Fly
gonad developmentGO:00084061410.026
male gamete generationGO:00482322850.026
negative regulation of molecular functionGO:00440922580.026
b cell activationGO:00421131610.026
response to organic cyclic compoundGO:00140701980.025
somatic diversification of immune receptors via somatic mutationGO:000256680.025
production of molecular mediator of immune responseGO:00024401030.025
cellular response to ionizing radiationGO:0071479110.025
Fly
leukocyte homeostasisGO:0001776790.025
regulation of chromatin organizationGO:1902275570.024
cellular response to oxidative stressGO:0034599760.024
lymphocyte homeostasisGO:0002260640.024
negative regulation of immune system processGO:00026832090.024
cytokine productionGO:00018163190.024
germ cell developmentGO:00072811850.024
Fly
regulation of cytokine productionGO:00018172660.024
positive regulation of protein phosphorylationGO:00019342420.024
negative regulation of dna replicationGO:000815640.023
Human
mitotic sister chromatid separationGO:005130690.023
negative regulation of phosphorylationGO:00423261660.023
cellular protein catabolic processGO:00442571550.023
Human
regulation of spindle organizationGO:009022420.023
dna integrity checkpointGO:0031570280.022
Human Fly
regulation of hydrolase activityGO:00513362460.022
Fly
negative regulation of transferase activityGO:0051348850.022
positive regulation of cell deathGO:00109422240.022
Fly
methylationGO:00322591340.022
purine ribonucleoside monophosphate catabolic processGO:0009169570.022
regulation of nucleotide metabolic processGO:00061401690.022
epithelial tube formationGO:00721751300.022
regulation of defense responseGO:00313472330.022
epithelial cell proliferationGO:00506731740.022
divalent metal ion transportGO:00708381720.022
regulation of purine nucleotide metabolic processGO:19005421690.021
response to oxidative stressGO:00069791230.021
cell cycle checkpointGO:0000075470.021
Human Fly
response to ionizing radiationGO:0010212420.021
cohesin localization to chromatinGO:007192110.021
lymphocyte mediated immunityGO:00024491390.021
protein processingGO:00164851630.021
Fly
muscle tissue developmentGO:00605373080.021
cellular homeostasisGO:00197252400.021
cellular lipid metabolic processGO:00442553230.021
regulation of cellular protein catabolic processGO:1903362610.020
mitotic nuclear divisionGO:0007067480.020
Human
positive regulation of kinase activityGO:00336741550.020
protein localization to organelleGO:00333651850.020
cellular response to acid chemicalGO:0071229680.020
rho protein signal transductionGO:0007266320.020
histone h3 k9 dimethylationGO:003612340.020
dna catabolic process endonucleolyticGO:0000737150.020
hematopoietic progenitor cell differentiationGO:00022441430.020
membrane organizationGO:00610242450.020
intrinsic apoptotic signaling pathway in response to dna damageGO:0008630570.020
Human Fly
macromolecular complex disassemblyGO:0032984430.020
development of primary sexual characteristicsGO:00451371430.020
cellular response to cytokine stimulusGO:00713451890.019
leukocyte apoptotic processGO:0071887710.019
protein modification by small protein conjugationGO:00324461870.019
regulation of cell cycle g2 m phase transitionGO:1902749100.019
cell type specific apoptotic processGO:00972852680.019
regulation of chromosome segregationGO:0051983210.019
regulation of bindingGO:00510981110.019
proteolysis involved in cellular protein catabolic processGO:00516031470.019
muscle cell differentiationGO:00426922610.019
mitotic sister chromatid cohesionGO:000706410.018
regulation of cell activationGO:00508652890.018
negative regulation of cell proliferationGO:00082852960.018
blood vessel morphogenesisGO:00485142850.018
response to organonitrogen compoundGO:00102432460.018
positive regulation of purine nucleotide metabolic processGO:19005441140.018
regulation of lymphocyte apoptotic processGO:0070228410.018
dna endoreduplicationGO:004202340.018
neural tube developmentGO:00219151600.018
peptidyl lysine modificationGO:0018205770.018
gtp catabolic processGO:00061841430.018
positive regulation of histone modificationGO:0031058280.018
regulation of protein catabolic processGO:00421761080.018
Human
regulation of proteolysis involved in cellular protein catabolic processGO:1903050560.018
proteasomal protein catabolic processGO:0010498980.018
myeloid cell homeostasisGO:00022621140.018
reactive oxygen species metabolic processGO:0072593840.017
spermatogenesisGO:00072832840.017
signal transduction in absence of ligandGO:0038034550.017
cellular protein complex disassemblyGO:0043624360.017
regulation of cellular component biogenesisGO:00440871810.017
lateral inhibitionGO:004633110.017
oogenesisGO:0048477560.017
protein ubiquitinationGO:00165671710.017
sensory perceptionGO:00076002450.017
negative regulation of cellular amino acid metabolic processGO:004576300.017
divalent inorganic cation transportGO:00725111780.017
locomotory behaviorGO:00076261950.017
cellular response to lipidGO:00713961450.017
positive regulation of chromosome organizationGO:2001252330.017
embryonic epithelial tube formationGO:00018381300.017
protein maturationGO:00516041760.017
Fly
chromosome organization involved in meiosisGO:0070192390.017
modification dependent macromolecule catabolic processGO:00436321330.017
erythrocyte differentiationGO:0030218880.017
cellular response to external stimulusGO:0071496880.017
chiasma assemblyGO:005102660.016
regulation of leukocyte apoptotic processGO:2000106560.016
positive regulation of purine nucleotide catabolic processGO:0033123880.016
leukocyte proliferationGO:00706611720.016
cell cycle g1 s phase transitionGO:0044843570.016
regulation of protein maturationGO:1903317960.016
positive regulation of histone h3 k9 methylationGO:005157440.016
regulation of epithelial cell proliferationGO:00506781410.016
positive regulation of protein kinase activityGO:00458601440.016
positive regulation of cell developmentGO:00107202370.016
regulation of cell cycle phase transitionGO:1901987770.016
Human Fly
centrosome organizationGO:0051297260.016
positive regulation of organelle organizationGO:00106381280.016
positive regulation of nervous system developmentGO:00519622210.016
regulation of nucleoside metabolic processGO:00091181300.015
striated muscle tissue developmentGO:00147062930.015
male meiosis chromosome segregationGO:000706030.015
microtubule polymerization or depolymerizationGO:0031109260.015
dna biosynthetic processGO:0071897220.015
carbohydrate derivative biosynthetic processGO:19011371830.015
lymphocyte proliferationGO:00466511640.015
negative regulation of mitotic cell cycle phase transitionGO:1901991450.015
Human Fly
endomembrane system organizationGO:00102561470.015
positive regulation of protein serine threonine kinase activityGO:00719021060.015
skeletal muscle organ developmentGO:00605381630.015
positive regulation of cell cycle processGO:0090068610.015
regulation of microtubule cytoskeleton organizationGO:0070507370.015
posttranscriptional regulation of gene expressionGO:00106081550.015
Human
negative regulation of nuclear divisionGO:0051784190.015
organonitrogen compound biosynthetic processGO:19015661920.015
neuron deathGO:00709971540.015
cellular protein complex assemblyGO:00436231160.015
epithelial tube morphogenesisGO:00605623030.015
dna modificationGO:0006304500.015
positive regulation of nucleotide metabolic processGO:00459811140.015
innate immune responseGO:00450871570.014
positive regulation of nucleotide catabolic processGO:0030813880.014
regulation of reactive oxygen species metabolic processGO:2000377400.014
multicellular organismal homeostasisGO:00488711640.014
calcium ion transportGO:00068161590.014
cellular chemical homeostasisGO:00550822150.014
t cell differentiationGO:00302171740.014
positive regulation of transferase activityGO:00513471670.014
meiotic chromosome segregationGO:0045132190.014
Worm
embryonic limb morphogenesisGO:00303261260.014
response to inorganic substanceGO:0010035960.014
regulation of interleukin 1 alpha secretionGO:005070530.014
t cell homeostasisGO:0043029350.014
positive regulation of histone methylationGO:0031062160.014
neural tube formationGO:00018411080.014
telomere maintenanceGO:0000723190.014
interleukin 8 productionGO:003263740.014
gland developmentGO:00487323300.013
regulation of proteolysisGO:00301621640.013
Fly
regulation of lymphocyte activationGO:00512492400.013
protein secretionGO:00093061110.013
negative regulation of cellular amine metabolic processGO:003323910.013
sister chromatid segregationGO:0000819200.013
macromolecule methylationGO:00434141200.013
synapsisGO:0007129340.013
regulation of multi organism processGO:00439001110.013
regulation of protein localization to nucleusGO:1900180600.013
dna hypermethylationGO:004402630.013
transmembrane transportGO:00550854120.013
digestive system developmentGO:00551232000.013
extrinsic apoptotic signaling pathwayGO:00971911260.013
regulation of nucleotide catabolic processGO:00308111220.013
developmental maturationGO:00217001930.013
regulation of purine nucleotide catabolic processGO:00331211220.013
rhythmic processGO:00485111740.013
bone developmentGO:00603481200.013
negative regulation of cell sizeGO:004579230.013
positive regulation of cytokine productionGO:00018191740.013
cellular response to hormone stimulusGO:00328701500.013
morphogenesis of embryonic epitheliumGO:00163311590.013
cellular macromolecule catabolic processGO:00442652060.013
Human
somatic cell dna recombinationGO:0016444510.013
negative regulation of kinase activityGO:0033673810.013
neuron apoptotic processGO:00514021420.012
tube formationGO:00351481400.012
regulation of mapk cascadeGO:00434082480.012
regulation of gtp catabolic processGO:00331241130.012
double strand break repair via nonhomologous end joiningGO:0006303100.012
g1 s transition of mitotic cell cycleGO:0000082570.012
cellular ion homeostasisGO:00068731650.012
somatic diversification of immunoglobulinsGO:0016445430.012
cellular response to organonitrogen compoundGO:00714171450.012
inflammatory responseGO:00069542440.012
lymphocyte differentiationGO:00300982420.012
heterochromatin organizationGO:007082840.012
regulation of interleukin 8 productionGO:003267730.012
telomere cappingGO:001623340.012
guanosine containing compound catabolic processGO:19010691440.012
gtp metabolic processGO:00460391440.012
regulation of neuron differentiationGO:00456642810.012
protein localization to chromatinGO:007116830.012
negative regulation of wnt signaling pathwayGO:0030178730.012
negative regulation of cytoskeleton organizationGO:0051494360.012
negative regulation of protein phosphorylationGO:00019331260.012
regulation of establishment of protein localizationGO:00702011810.012
metaphase anaphase transition of mitotic cell cycleGO:000709190.012
t cell activationGO:00421102890.012
spindle midzone assemblyGO:005125510.012
negative regulation of transcription involved in g1 s transition of mitotic cell cycleGO:007193010.012
b cell differentiationGO:0030183780.012
regulation of intrinsic apoptotic signaling pathwayGO:2001242610.012
cellular response to biotic stimulusGO:0071216920.012
positive regulation of interleukin 8 productionGO:003275720.011
extrinsic apoptotic signaling pathway in absence of ligandGO:0097192550.011
spindle organizationGO:0007051280.011
Human
regulation of anatomical structure sizeGO:00900661780.011
spindle assembly involved in female meiosisGO:000705630.011
endocytosisGO:00068971680.011
cell maturationGO:00484691270.011
regulation of leukocyte differentiationGO:19021051590.011
regulation of cysteine type endopeptidase activityGO:2000116650.011
Fly
regulation of canonical wnt signaling pathwayGO:0060828820.011
regulation of t cell activationGO:00508631700.011
t cell apoptotic processGO:0070231390.011
reciprocal dna recombinationGO:0035825160.011
regulation of cell projection organizationGO:00313442060.011
digestive tract morphogenesisGO:00485461470.011
organophosphate biosynthetic processGO:00904071220.011
response to oxygen levelsGO:0070482620.011
intestinal epithelial structure maintenanceGO:006072940.011
nucleotide biosynthetic processGO:0009165780.011
negative regulation of protein modification processGO:00314001630.011
regulation of cell migrationGO:00303342190.011
tricarboxylic acid metabolic processGO:007235050.011
blood circulationGO:00080151950.011
regulation of double strand break repair via homologous recombinationGO:001056920.011
carbohydrate homeostasisGO:00335001280.011
striated muscle cell developmentGO:00550021250.011
positive regulation of apoptotic signaling pathwayGO:2001235950.011
response to acid chemicalGO:00011011110.011
cell cycle arrestGO:0007050370.011
response to molecule of bacterial originGO:00022371430.011
axonogenesisGO:00074092740.011
regulation of cytoplasmic transportGO:19036491120.011
regionalizationGO:00030023370.011
rna dependent dna replicationGO:000627830.011
sequestering of calcium ionGO:0051208180.011
negative regulation of apoptotic signaling pathwayGO:20012341040.011
fibroblast proliferationGO:0048144350.011
lipid biosynthetic processGO:00086101790.011
digestive tract developmentGO:00485651900.010
negative regulation of homeostatic processGO:0032845710.010
regulation of cellular response to stressGO:00801351590.010
Fly
canonical wnt signaling pathwayGO:00600701300.010
cellular response to light stimulusGO:0071482190.010
rna interferenceGO:001624620.010
regulation of intracellular protein transportGO:0033157820.010
asymmetric neuroblast divisionGO:005505910.010
cellularizationGO:000734910.010
angiogenesisGO:00015252010.010
cell cycle g2 m phase transitionGO:0044839200.010
Human
mitotic recombinationGO:000631230.010
skeletal system developmentGO:00015013560.010
response to growth factorGO:00708481980.010
cilium morphogenesisGO:00602711020.010
striated muscle myosin thick filament assemblyGO:007168810.010
cellular response to growth factor stimulusGO:00713631970.010
negative regulation of protein catabolic processGO:0042177360.010
protein acylationGO:0043543640.010
somatic hypermutation of immunoglobulin genesGO:001644670.010
cell growthGO:00160491300.010
mapk cascadeGO:00001652810.010
translesion synthesisGO:001998510.010

Chek2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
organ system cancerDOID:005068600.086
Human
disease of cellular proliferationDOID:1456600.086
Human
cancerDOID:16200.086
Human
thoracic cancerDOID:509300.032
Human
breast cancerDOID:161200.018
Human
anemiaDOID:235500.015
congenital hypoplastic anemiaDOID:134200.015
bone marrow diseaseDOID:496100.015
immune system diseaseDOID:291400.015
aplastic anemiaDOID:1244900.015
hematopoietic system diseaseDOID:7400.015
disease of anatomical entityDOID:700.015
intestinal cancerDOID:1015500.015
gastrointestinal system cancerDOID:311900.015
large intestine cancerDOID:567200.011
immune system cancerDOID:006008300.010