Mus musculus

151 known processes

Chek1

checkpoint kinase 1 homolog (S. pombe)

(Aliases: rad27,Chk1,C85740)

Chek1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
dna metabolic processGO:00062593030.960
microtubule cytoskeleton organizationGO:00002261570.783
Human
cellular response to dna damage stimulusGO:00069742070.776
meiotic cell cycleGO:00513211220.749
dna repairGO:00062811070.716
nuclear divisionGO:00002801580.681
Human
meiosis iGO:0007127600.603
double strand break repairGO:0006302480.599
Human
organelle fissionGO:00482851700.591
Human
mitotic cell cycle processGO:19030471590.563
cellular macromolecule catabolic processGO:00442652060.544
modification dependent protein catabolic processGO:00199411330.496
cellular protein catabolic processGO:00442571550.466
meiotic nuclear divisionGO:00071261150.462
meiotic cell cycle processGO:1903046770.444
regulation of cell cycleGO:00517262810.426
Human Zebrafish Rat
negative regulation of cell cycleGO:00457861230.418
Human Zebrafish Rat
regulation of cell divisionGO:0051302760.391
Human
gonad developmentGO:00084061410.380
chromosome segregationGO:0007059480.372
female meiosis chromosome segregationGO:001632110.344
mitotic sister chromatid cohesionGO:000706410.313
dna recombinationGO:0006310920.293
Human
cell cycle checkpointGO:0000075470.283
protein catabolic processGO:00301632210.272
development of primary sexual characteristicsGO:00451371430.265
dna endoreduplicationGO:004202340.257
regulation of mitotic cell cycle phase transitionGO:1901990730.257
Zebrafish Rat
macromolecule catabolic processGO:00090572810.251
mitotic sister chromatid segregationGO:0000070140.247
regulation of mitotic cell cycleGO:00073461260.239
Human Zebrafish Rat
mitotic cell cycleGO:00002781950.230
regulation of cell cycle phase transitionGO:1901987770.227
Zebrafish Rat
regulation of cell cycle processGO:00105641600.227
Human Zebrafish Rat
proteolysis involved in cellular protein catabolic processGO:00516031470.220
ubiquitin dependent protein catabolic processGO:00065111290.213
translesion synthesisGO:001998510.212
regulation of mitosisGO:0007088290.212
Human
negative regulation of cell cycle phase transitionGO:1901988480.210
Zebrafish Rat
regulation of chromosome organizationGO:0033044830.199
heterochromatin organizationGO:007082840.195
microtubule based processGO:00070172360.186
Human
dna replicationGO:0006260520.177
regulation of cellular catabolic processGO:00313292420.171
protein ubiquitinationGO:00165671710.168
female meiotic divisionGO:0007143210.164
positive regulation of cell cycleGO:0045787920.159
recombinational repairGO:0000725210.156
Human
organelle assemblyGO:00709251770.155
dna dependent dna replicationGO:0006261240.152
purine nucleotide metabolic processGO:00061633020.145
chromatin organizationGO:00063252060.144
negative regulation of nuclear divisionGO:0051784190.140
Human
nucleoside triphosphate metabolic processGO:00091412300.136
negative regulation of mitotic cell cycleGO:0045930580.136
Human Zebrafish Rat
mitotic nuclear divisionGO:0007067480.134
Human
genitalia developmentGO:0048806370.133
male gamete generationGO:00482322850.131
response to light stimulusGO:00094161350.129
apoptotic signaling pathwayGO:00971903060.123
Zebrafish
maintenance of locationGO:0051235890.113
intrinsic apoptotic signaling pathwayGO:00971931320.112
Zebrafish
response to radiationGO:00093141650.111
ribonucleoside catabolic processGO:00424542060.108
establishment of organelle localizationGO:00516561220.104
male meiosisGO:0007140370.102
organonitrogen compound catabolic processGO:19015652640.100
regulation of organelle organizationGO:00330432890.097
purine ribonucleotide metabolic processGO:00091502900.091
modification dependent macromolecule catabolic processGO:00436321330.090
spermatogenesisGO:00072832840.088
purine nucleoside monophosphate catabolic processGO:0009128580.088
sister chromatid segregationGO:0000819200.083
double strand break repair via homologous recombinationGO:0000724210.083
Human
purine nucleoside triphosphate metabolic processGO:00091442260.082
dna replication independent nucleosome assemblyGO:000633610.081
nucleoside phosphate metabolic processGO:00067533380.080
positive regulation of apoptotic processGO:00430652170.078
ribose phosphate metabolic processGO:00196932910.078
cell divisionGO:00513011200.077
Human
protein modification by small protein conjugation or removalGO:00706472070.073
mitotic chromosome condensationGO:000707610.073
atp metabolic processGO:0046034750.072
cellular response to abiotic stimulusGO:0071214560.071
cellular ketone metabolic processGO:0042180840.070
microtubule organizing center organizationGO:0031023280.070
Human
positive regulation of programmed cell deathGO:00430682180.069
glycosyl compound catabolic processGO:19016582060.068
negative regulation of cell cycle processGO:0010948690.068
Human Zebrafish Rat
negative regulation of cellular component organizationGO:00511291940.067
Human
regulation of proteasomal protein catabolic processGO:0061136460.066
negative regulation of cell divisionGO:0051782240.066
Human
dna biosynthetic processGO:0071897220.064
Rat
proteasomal protein catabolic processGO:0010498980.063
intrinsic apoptotic signaling pathway in response to dna damageGO:0008630570.062
Zebrafish
cellular amino acid metabolic processGO:00065201030.060
dna packagingGO:0006323300.060
cellular response to radiationGO:0071478280.060
nucleoside metabolic processGO:00091162460.059
chromatin modificationGO:00165681870.058
purine nucleoside triphosphate catabolic processGO:00091462030.057
cell differentiation involved in embryonic placenta developmentGO:0060706260.056
negative regulation of organelle organizationGO:0010639900.056
Human
ribonucleoside metabolic processGO:00091192450.055
endocytosisGO:00068971680.052
centromere complex assemblyGO:003450830.052
ribonucleoside triphosphate metabolic processGO:00091992200.052
purine containing compound catabolic processGO:00725232130.052
purine nucleoside catabolic processGO:00061522050.051
meiotic chromosome segregationGO:0045132190.051
nucleoside phosphate catabolic processGO:19012922220.051
purine nucleoside metabolic processGO:00422782410.050
glycosyl compound metabolic processGO:19016572460.049
cellular amine metabolic processGO:0044106440.049
negative regulation of meiotic cell cycle phase transitionGO:190199430.049
carbohydrate derivative catabolic processGO:19011362310.049
organic cyclic compound catabolic processGO:19013612950.048
regulation of apoptotic signaling pathwayGO:20012331970.048
regulation of dna replicationGO:0006275170.048
purine ribonucleoside metabolic processGO:00461282410.047
regulation of proteolysis involved in cellular protein catabolic processGO:1903050560.047
centrosome duplicationGO:0051298160.047
covalent chromatin modificationGO:00165691630.046
purine ribonucleotide catabolic processGO:00091542080.046
chromatin assembly or disassemblyGO:0006333160.046
spindle assembly involved in female meiosisGO:000705630.045
purine nucleoside monophosphate metabolic processGO:0009126810.045
response to ionizing radiationGO:0010212420.045
regulation of meiosis iGO:006063170.044
nucleobase containing small molecule metabolic processGO:00550863520.044
response to organonitrogen compoundGO:00102432460.043
Rat
negative regulation of mitotic cell cycle phase transitionGO:1901991450.043
Zebrafish Rat
receptor mediated endocytosisGO:0006898510.043
spindle assembly involved in mitosisGO:009030740.042
organophosphate catabolic processGO:00464342320.042
cell cycle comprising mitosis without cytokinesisGO:003330110.042
cell fate commitmentGO:00451652100.042
proteasome mediated ubiquitin dependent protein catabolic processGO:0043161880.041
regulation of cellular protein catabolic processGO:1903362610.040
chromosome separationGO:0051304140.039
histone modificationGO:00165701590.039
multicellular organism growthGO:00352641610.039
nucleotide metabolic processGO:00091173320.039
amine metabolic processGO:0009308450.039
regulation of proteolysisGO:00301621640.038
regulation of proteasomal ubiquitin dependent protein catabolic processGO:0032434400.038
ribonucleotide metabolic processGO:00092592910.037
regulation of cellular component sizeGO:00325351210.037
purine ribonucleoside triphosphate metabolic processGO:00092052200.037
nucleoside triphosphate catabolic processGO:00091432050.036
cellular nitrogen compound catabolic processGO:00442702800.036
purine ribonucleoside triphosphate catabolic processGO:00092071990.036
trophoblast giant cell differentiationGO:0060707150.036
myosin filament organizationGO:003103330.036
positive regulation of cell deathGO:00109422240.035
regulation of hydrolase activityGO:00513362460.035
regulation of metaphase anaphase transition of cell cycleGO:190209990.035
macromolecule methylationGO:00434141200.035
regulation of nuclear divisionGO:0051783560.035
Human
mitotic recombinationGO:000631230.034
ribonucleotide catabolic processGO:00092612080.034
protein maturationGO:00516041760.034
metaphase plate congressionGO:005131020.034
nucleoside catabolic processGO:00091642060.034
regulation of protein maturationGO:1903317960.034
negative regulation of cellular protein metabolic processGO:00322692470.034
synapsisGO:0007129340.033
regulation of protein kinase activityGO:00458592320.033
germ cell developmentGO:00072811850.033
nucleoside monophosphate metabolic processGO:0009123850.033
sister chromatid cohesionGO:0007062120.033
dna conformation changeGO:0071103370.032
spindle organizationGO:0007051280.032
response to uvGO:0009411440.032
regulation of mitotic sister chromatid separationGO:0010965120.032
heterocycle catabolic processGO:00467002800.031
negative regulation of protein metabolic processGO:00512482820.031
nucleotide catabolic processGO:00091662170.031
attachment of spindle microtubules to kinetochoreGO:000860840.031
chromatin remodeling at centromereGO:003105520.031
purine containing compound metabolic processGO:00725213110.031
cellularizationGO:000734910.030
cellular response to organonitrogen compoundGO:00714171450.030
Rat
regulation of transferase activityGO:00513382630.030
regulation of cell activationGO:00508652890.030
intracellular mrna localizationGO:000829840.030
purine ribonucleoside monophosphate metabolic processGO:0009167800.029
chromatin assemblyGO:0031497130.029
chromosome organization involved in meiosisGO:0070192390.029
ribonucleoside monophosphate catabolic processGO:0009158570.029
regulation of intrinsic apoptotic signaling pathwayGO:2001242610.029
regulation of chromosome segregationGO:0051983210.028
negative regulation of mitotic sister chromatid segregationGO:003304870.027
positive regulation of apoptotic signaling pathwayGO:2001235950.027
positive regulation of cellular amino acid metabolic processGO:004576430.027
spindle assembly involved in meiosisGO:009030640.027
cellular response to ionizing radiationGO:0071479110.026
negative regulation of cellular protein catabolic processGO:1903363220.026
regulation of centriole replicationGO:004659910.026
negative regulation of phosphate metabolic processGO:00459361840.026
reciprocal dna recombinationGO:0035825160.026
membrane organizationGO:00610242450.026
response to organic cyclic compoundGO:00140701980.025
Rat
nucleoside monophosphate catabolic processGO:0009125590.025
dna modificationGO:0006304500.025
positive regulation of cellular amine metabolic processGO:003324050.025
purine nucleotide catabolic processGO:00061952110.024
ribonucleoside triphosphate catabolic processGO:00092031990.024
positive regulation of cell developmentGO:00107202370.024
negative regulation of proteolysisGO:0045861740.024
negative regulation of proteasomal ubiquitin dependent protein catabolic processGO:0032435150.024
regulation of cellular amino acid metabolic processGO:000652150.024
regulation of cellular amine metabolic processGO:0033238200.024
male meiosis iGO:0007141160.024
regulation of protein catabolic processGO:00421761080.023
regulation of sister chromatid cohesionGO:000706350.023
postreplication repairGO:000630150.023
centrosome cycleGO:0007098230.023
Human
striated muscle myosin thick filament assemblyGO:007168810.022
cilium morphogenesisGO:00602711020.022
cellular response to gamma radiationGO:007148040.022
atp catabolic processGO:0006200550.022
cell type specific apoptotic processGO:00972852680.021
spermatid developmentGO:00072861080.021
placenta developmentGO:00018901400.021
dna catabolic processGO:0006308190.020
cellular component assembly involved in morphogenesisGO:00109271390.020
mitotic cytokinesisGO:000028140.020
protein processingGO:00164851630.020
negative regulation of molecular functionGO:00440922580.020
regulation of dna dependent dna replicationGO:009032980.020
blastocyst developmentGO:0001824800.019
cell cycle g1 s phase transitionGO:0044843570.019
regulation of protein localizationGO:00328802310.019
spermatid differentiationGO:00485151150.019
folic acid containing compound metabolic processGO:000676030.019
negative regulation of mitotic sister chromatid separationGO:200081670.019
protein secretionGO:00093061110.019
mitotic sister chromatid separationGO:005130690.019
histone acetylationGO:0016573410.019
negative regulation of transcription involved in g1 s transition of mitotic cell cycleGO:007193010.018
metaphase anaphase transition of mitotic cell cycleGO:000709190.018
female gamete generationGO:0007292740.018
negative regulation of protein maturationGO:1903318790.018
regulation of kinase activityGO:00435492490.018
protein localization to organelleGO:00333651850.018
rhythmic processGO:00485111740.018
regulation of cytokinesisGO:003246550.017
positive regulation of protein modification processGO:00314012990.017
aromatic compound catabolic processGO:00194392860.017
positive regulation of hydrolase activityGO:00513451480.017
negative regulation of proteolysis involved in cellular protein catabolic processGO:1903051220.017
axoneme assemblyGO:0035082150.017
regulation of t cell activationGO:00508631700.017
nuclear dna replicationGO:003326030.017
negative regulation of sister chromatid segregationGO:003304670.017
endomembrane system organizationGO:00102561470.017
dna dependent dna replication maintenance of fidelityGO:004500530.017
kinetochore organizationGO:005138320.017
negative regulation of cellular amino acid metabolic processGO:004576300.016
purine ribonucleoside catabolic processGO:00461302050.016
positive regulation of histone h3 k9 methylationGO:005157440.016
nucleic acid phosphodiester bond hydrolysisGO:0090305490.016
regulation of cellular ketone metabolic processGO:0010565660.016
reciprocal meiotic recombinationGO:0007131160.016
cell maturationGO:00484691270.016
b cell activationGO:00421131610.016
oogenesisGO:0048477560.016
protein import into nucleusGO:0006606950.016
regulation of peptidase activityGO:0052547960.015
negative regulation of intracellular signal transductionGO:19025321670.015
muscle cell differentiationGO:00426922610.015
regulation of double strand break repair via homologous recombinationGO:001056920.015
Human
methylationGO:00322591340.015
peptidyl amino acid modificationGO:00181933360.015
myosin filament assemblyGO:003103420.015
ossificationGO:00015032160.015
positive regulation of protein kinase activityGO:00458601440.014
g1 s transition of mitotic cell cycleGO:0000082570.014
positive regulation of mitotic cell cycleGO:0045931410.014
fertilizationGO:00095661270.014
neuron migrationGO:00017641220.014
regulation of protein processingGO:0070613960.014
regulation of attachment of spindle microtubules to kinetochoreGO:005198830.014
positive regulation of nervous system developmentGO:00519622210.014
positive regulation of cell cycle processGO:0090068610.014
leukocyte differentiationGO:00025213420.014
protein oligomerizationGO:0051259670.014
regulation of lymphocyte activationGO:00512492400.014
purine ribonucleoside monophosphate catabolic processGO:0009169570.014
lymphocyte differentiationGO:00300982420.014
spindle assemblyGO:0051225130.014
protein modification by small protein conjugationGO:00324461870.014
negative regulation of cell proliferationGO:00082852960.014
mitotic cell cycle checkpointGO:0007093310.013
Zebrafish
regulation of cell sizeGO:0008361720.013
dna catabolic process exonucleolyticGO:000073830.013
regulation of nuclear cell cycle dna replicationGO:003326220.013
negative regulation of transferase activityGO:0051348850.013
histone h3 k9 methylationGO:0051567170.013
mitotic spindle organizationGO:0007052100.013
muscle cell developmentGO:00550011330.013
wnt signaling pathwayGO:00160551880.013
histone h3 k9 dimethylationGO:003612340.013
meiotic cell cycle checkpointGO:003331320.013
developmental maturationGO:00217001930.012
response to hypoxiaGO:0001666580.012
oocyte maturationGO:0001556180.012
dna methylationGO:0006306430.012
regulation of transcription by chromatin organizationGO:003440100.012
negative regulation of eosinophil degranulationGO:004331010.012
striated muscle cell developmentGO:00550021250.012
regulation of wnt signaling pathwayGO:00301111230.012
negative regulation of protein processingGO:0010955790.012
negative regulation of protein catabolic processGO:0042177360.012
negative regulation of metaphase anaphase transition of cell cycleGO:190210080.012
dna damage checkpointGO:0000077260.012
heterochromatin assemblyGO:003150720.012
centrosome separationGO:005129940.012
Human
dna catabolic process endonucleolyticGO:0000737150.012
myeloid cell differentiationGO:00300992330.012
posttranscriptional regulation of gene expressionGO:00106081550.012
response to oxygen levelsGO:0070482620.012
regulation of cyclin dependent protein serine threonine kinase activityGO:0000079160.012
positive regulation of kinase activityGO:00336741550.011
rho protein signal transductionGO:0007266320.011
cellular response to hormone stimulusGO:00328701500.011
protein polyubiquitinationGO:0000209330.011
histone threonine phosphorylationGO:003540510.011
regulation of mitotic sister chromatid segregationGO:0033047120.011
response to decreased oxygen levelsGO:0036293590.011
anatomical structure homeostasisGO:00602491450.011
rac protein signal transductionGO:0016601130.011
regulation of leukocyte apoptotic processGO:2000106560.011
negative regulation of mitosisGO:0045839100.011
Human
cellular response to cytokine stimulusGO:00713451890.011
regulation of response to woundingGO:19030341890.011
negative regulation of phosphorus metabolic processGO:00105631840.011
regulation of canonical wnt signaling pathwayGO:0060828820.011
cellular response to oxidative stressGO:0034599760.011
negative regulation of mitotic metaphase anaphase transitionGO:004584170.011
positive regulation of lymphocyte activationGO:00512511400.011
mesodermal cell migrationGO:000807840.011
regulation of purine nucleotide metabolic processGO:19005421690.011
organelle localizationGO:00516401790.011
positive regulation of protein phosphorylationGO:00019342420.010
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071692470.010
negative regulation of cellular catabolic processGO:0031330470.010
multi multicellular organism processGO:00447061090.010
positive regulation of cellular catabolic processGO:00313311480.010
regulation of cellular response to stressGO:00801351590.010
Human
regulation of mitotic metaphase anaphase transitionGO:003007180.010
male gonad developmentGO:0008584880.010
gene silencingGO:0016458380.010

Chek1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
thoracic cancerDOID:509300.060
cancerDOID:16200.060
disease of cellular proliferationDOID:1456600.060
breast cancerDOID:161200.060
organ system cancerDOID:005068600.060