IMP: Integrative Multi-species Prediction

Mus musculus

33 known processes

Hsp90aa1

heat shock protein 90, alpha (cytosolic), class A member 1

(Aliases: 89kDa,86kDa,AL024147,AL024080,Hsp90,Hsp86-1,hsp4,Hspca,Hsp89)

Entrez: 15519
Ensembl: ENSMUSG00000021270
UniProtKB: P07901
UniProtKB: Q80Y52

Process Predictions
Disease Predictions

Hsp90aa1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
protein refolding	GO:0042026	1	1.000	Yeast
protein targeting to mitochondrion	GO:0006626	6	0.995	Yeast
microtubule cytoskeleton organization	GO:0000226	157	0.994	Fly
organelle assembly	GO:0070925	177	0.993	Zebrafish
microtubule based process	GO:0007017	236	0.986	Fly
protein transmembrane transport	GO:0071806	8	0.982
negative regulation of transposition	GO:0010529	2	0.914	Fly
sperm egg recognition	GO:0035036	37	0.910
centrosome cycle	GO:0007098	23	0.901	Fly
de novo protein folding	GO:0006458	9	0.891	Yeast
protein folding	GO:0006457	28	0.859	Yeast
chaperone mediated protein folding	GO:0061077	10	0.848
vesicle uncoating	GO:0072319	4	0.768
response to heat	GO:0009408	27	0.759	Yeast Rat Fly
intracellular protein transport	GO:0006886	204	0.749	Yeast Rat
regulation of transferase activity	GO:0051338	263	0.747
regulation of protein serine threonine kinase activity	GO:0071900	157	0.746
cell cell recognition	GO:0009988	44	0.719
binding of sperm to zona pellucida	GO:0007339	34	0.681
regulation of protein kinase activity	GO:0045859	232	0.628
cellular protein complex assembly	GO:0043623	116	0.624	Yeast Zebrafish
negative regulation of cellular protein metabolic process	GO:0032269	247	0.613
protein localization to organelle	GO:0033365	185	0.611	Yeast Rat
regulation of cellular response to stress	GO:0080135	159	0.610
microtubule organizing center organization	GO:0031023	28	0.602	Fly
dna metabolic process	GO:0006259	303	0.601	Yeast
protein import into nucleus translocation	GO:0000060	12	0.556	Rat
atp catabolic process	GO:0006200	55	0.548	Yeast Worm
organelle disassembly	GO:1903008	2	0.537
regulation of cytoskeleton organization	GO:0051493	122	0.536
ribonucleoside triphosphate catabolic process	GO:0009203	199	0.534	Yeast Worm
centrosome organization	GO:0051297	26	0.532	Fly
rna processing	GO:0006396	105	0.528
ribonucleoprotein complex disassembly	GO:0032988	3	0.527
myosin filament organization	GO:0031033	3	0.524	Zebrafish
regulation of transposition	GO:0010528	2	0.518	Fly
regulation of kinase activity	GO:0043549	249	0.514
protein import into nucleus	GO:0006606	95	0.504	Rat
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.496	Yeast Worm
protein targeting	GO:0006605	143	0.475	Yeast Rat
cellular response to cytokine stimulus	GO:0071345	189	0.474	Mouse
glycosyl compound catabolic process	GO:1901658	206	0.468	Yeast Worm
carbohydrate derivative catabolic process	GO:1901136	231	0.467	Yeast Worm
protein import	GO:0017038	101	0.463	Rat
negative regulation of protein serine threonine kinase activity	GO:0071901	49	0.460
rna splicing	GO:0008380	54	0.460
cellular nitrogen compound catabolic process	GO:0044270	280	0.454	Yeast Worm
rna dependent dna replication	GO:0006278	3	0.447	Yeast
purine ribonucleoside metabolic process	GO:0046128	241	0.445	Yeast Worm
muscle cell differentiation	GO:0042692	261	0.442	Zebrafish
protein localization to nucleus	GO:0034504	121	0.441	Rat
cellular component assembly involved in morphogenesis	GO:0010927	139	0.436	Zebrafish
spindle assembly involved in mitosis	GO:0090307	4	0.424
single fertilization	GO:0007338	82	0.421
negative regulation of protein modification process	GO:0031400	163	0.420
positive regulation of dna replication	GO:0045740	9	0.415	Yeast
actin filament organization	GO:0007015	113	0.414	Zebrafish Fly
circadian sleep wake cycle	GO:0042745	5	0.414	Fly
regulation of cell cycle	GO:0051726	281	0.396
regulation of intracellular transport	GO:0032386	159	0.391	Rat
negative regulation of transferase activity	GO:0051348	85	0.381
cell type specific apoptotic process	GO:0097285	268	0.370	Rat
toxin transport	GO:1901998	38	0.369
regulation of establishment of protein localization	GO:0070201	181	0.366	Rat
renal system development	GO:0072001	225	0.364
negative regulation of kinase activity	GO:0033673	81	0.360
mitochondrial transport	GO:0006839	36	0.351	Yeast
nucleocytoplasmic transport	GO:0006913	139	0.349	Rat
fertilization	GO:0009566	127	0.347
regulation of reactive oxygen species metabolic process	GO:2000377	40	0.343
establishment of protein localization to mitochondrion	GO:0072655	11	0.341	Yeast
regulation of mrna processing	GO:0050684	41	0.336
regulation of protein import into nucleus translocation	GO:0033158	2	0.335	Rat
purine nucleotide catabolic process	GO:0006195	211	0.330	Yeast Worm
spermatogenesis	GO:0007283	284	0.329	Fly
negative regulation of protein phosphorylation	GO:0001933	126	0.328
negative regulation of protein metabolic process	GO:0051248	282	0.322
stress granule disassembly	GO:0035617	2	0.317
receptor mediated endocytosis	GO:0006898	51	0.313
purine ribonucleoside monophosphate catabolic process	GO:0009169	57	0.312	Yeast Worm
negative regulation of molecular function	GO:0044092	258	0.312
nuclear import	GO:0051170	95	0.309	Rat
ribonucleoside catabolic process	GO:0042454	206	0.308	Yeast Worm
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.307	Yeast Worm
positive regulation of cell death	GO:0010942	224	0.300
photoreceptor cell development	GO:0042461	40	0.299
regulation of cytoplasmic transport	GO:1903649	112	0.299	Rat
regulation of cell cycle process	GO:0010564	160	0.297
cellular response to topologically incorrect protein	GO:0035967	25	0.294
ribonucleoprotein complex subunit organization	GO:0071826	28	0.291	Yeast
nucleoside phosphate catabolic process	GO:1901292	222	0.290	Yeast Worm
gonad development	GO:0008406	141	0.290	Worm
purine nucleotide metabolic process	GO:0006163	302	0.289	Yeast Worm
intracellular steroid hormone receptor signaling pathway	GO:0030518	29	0.274
regionalization	GO:0003002	337	0.273	Fly
transmembrane transport	GO:0055085	412	0.268
regulation of mrna splicing via spliceosome	GO:0048024	32	0.265
regulation of protein transport	GO:0051223	163	0.264	Rat
negative regulation of phosphorylation	GO:0042326	166	0.264
regulation of rna splicing	GO:0043484	37	0.263
nucleoside metabolic process	GO:0009116	246	0.260	Yeast Worm
response to organonitrogen compound	GO:0010243	246	0.257
multicellular organismal aging	GO:0010259	24	0.256	Worm
cell recognition	GO:0008037	83	0.255
nucleotide catabolic process	GO:0009166	217	0.254	Yeast Worm
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.251	Yeast Worm
purine containing compound catabolic process	GO:0072523	213	0.250	Yeast Worm
oocyte anterior posterior axis specification	GO:0007314	2	0.247	Fly
macromolecule catabolic process	GO:0009057	281	0.244
establishment of protein localization to organelle	GO:0072594	118	0.244	Yeast Rat
regulation of microtubule based process	GO:0032886	52	0.243
nuclear transport	GO:0051169	139	0.242	Rat
nucleoside triphosphate catabolic process	GO:0009143	205	0.242	Yeast Worm
mitotic cell cycle process	GO:1903047	159	0.230	Fly
purine nucleoside monophosphate catabolic process	GO:0009128	58	0.223	Yeast Worm
development of primary sexual characteristics	GO:0045137	143	0.222	Worm
rhythmic process	GO:0048511	174	0.222	Fly
ribonucleoside monophosphate catabolic process	GO:0009158	57	0.220	Yeast Worm
regulation of nucleocytoplasmic transport	GO:0046822	73	0.220	Rat
cell growth	GO:0016049	130	0.216
ribose phosphate metabolic process	GO:0019693	291	0.215	Yeast Worm
positive regulation of apoptotic process	GO:0043065	217	0.213
maturation of 5 8s rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna	GO:0000466	1	0.213
response to temperature stimulus	GO:0009266	55	0.213	Yeast Rat Fly
mitochondrion organization	GO:0007005	134	0.212	Yeast
ribonucleoprotein complex localization	GO:0071166	1	0.209
axonal fasciculation	GO:0007413	15	0.208
cytoplasmic transport	GO:0016482	234	0.208	Yeast Rat
positive regulation of reactive oxygen species biosynthetic process	GO:1903428	2	0.203
purine nucleoside metabolic process	GO:0042278	241	0.199	Yeast Worm
positive regulation of transferase activity	GO:0051347	167	0.197
ribonucleotide metabolic process	GO:0009259	291	0.193	Yeast Worm
protein localization to mitochondrion	GO:0070585	15	0.193	Yeast
response to topologically incorrect protein	GO:0035966	25	0.190
mitotic cell cycle	GO:0000278	195	0.189	Fly
organelle localization	GO:0051640	179	0.184
purine ribonucleoside catabolic process	GO:0046130	205	0.182	Yeast Worm
glycosyl compound metabolic process	GO:1901657	246	0.182	Yeast Worm
protein targeting to membrane	GO:0006612	20	0.181
establishment of protein localization to membrane	GO:0090150	54	0.179
regulation of centrosome cycle	GO:0046605	10	0.175
posttranscriptional regulation of gene expression	GO:0010608	155	0.175
negative regulation of phosphorus metabolic process	GO:0010563	184	0.173
macromolecular complex disassembly	GO:0032984	43	0.173
pore complex assembly	GO:0046931	3	0.172
meiotic nuclear division	GO:0007126	115	0.168
cellular response to interleukin 4	GO:0071353	21	0.167	Mouse
translation	GO:0006412	93	0.165
nucleotide metabolic process	GO:0009117	332	0.162	Yeast Worm
gene silencing by rna	GO:0031047	19	0.161
pole plasm assembly	GO:0007315	2	0.160	Fly
ribonucleotide catabolic process	GO:0009261	208	0.159	Yeast Worm
cellular response to heat	GO:0034605	15	0.154	Yeast
organic cyclic compound catabolic process	GO:1901361	295	0.154	Yeast Worm
negative regulation of cellular component organization	GO:0051129	194	0.153
positive regulation of mrna metabolic process	GO:1903313	17	0.152
spindle organization	GO:0007051	28	0.151	Fly
positive regulation of intracellular protein transport	GO:0090316	42	0.151	Rat
nucleoside catabolic process	GO:0009164	206	0.143	Yeast Worm
regulation of protein stability	GO:0031647	52	0.140
dendrite development	GO:0016358	115	0.140
organophosphate catabolic process	GO:0046434	232	0.139	Yeast Worm
meiotic cell cycle	GO:0051321	122	0.139
genitalia development	GO:0048806	37	0.138	Worm
cytokine production involved in immune response	GO:0002367	34	0.137
response to interleukin 4	GO:0070670	23	0.136	Mouse
regulation of circadian sleep wake cycle sleep	GO:0045187	3	0.136	Fly
positive regulation of mrna processing	GO:0050685	16	0.136
cellular protein catabolic process	GO:0044257	155	0.135
regulation of circadian rhythm	GO:0042752	58	0.135	Fly
leukocyte proliferation	GO:0070661	172	0.133
actomyosin structure organization	GO:0031032	56	0.131	Zebrafish
centrosome duplication	GO:0051298	16	0.126
habituation	GO:0046959	3	0.126
germ cell development	GO:0007281	185	0.123	Fly
protein targeting to er	GO:0045047	2	0.121
camera type eye development	GO:0043010	266	0.120
regulation of dna replication	GO:0006275	17	0.119	Yeast
regulation of polyamine transmembrane transport	GO:1902267	5	0.116
posttranscriptional gene silencing	GO:0016441	10	0.116
regulation of organelle organization	GO:0033043	289	0.112	Yeast
regulation of peptidase activity	GO:0052547	96	0.110
regulation of anatomical structure size	GO:0090066	178	0.109	Rat
telomere maintenance via telomerase	GO:0007004	1	0.108	Yeast
nucleoside monophosphate metabolic process	GO:0009123	85	0.108	Yeast Worm
regulation of protein localization	GO:0032880	231	0.106	Rat
single organism nuclear import	GO:1902593	95	0.105	Rat
purine ribonucleotide catabolic process	GO:0009154	208	0.105	Yeast Worm
regulation of cell projection organization	GO:0031344	206	0.103	Rat
sensory organ morphogenesis	GO:0090596	242	0.103
establishment of organelle localization	GO:0051656	122	0.103
rna localization	GO:0006403	23	0.102	Fly
regulation of microtubule cytoskeleton organization	GO:0070507	37	0.102
heterocycle catabolic process	GO:0046700	280	0.101	Yeast Worm
response to osmotic stress	GO:0006970	21	0.101	Yeast Rat
rna interference	GO:0016246	2	0.101
striated muscle cell development	GO:0055002	125	0.101	Zebrafish
protein depolymerization	GO:0051261	34	0.100
regulation of ion transport	GO:0043269	215	0.100
ribonucleoside metabolic process	GO:0009119	245	0.100	Yeast Worm
atp metabolic process	GO:0046034	75	0.096	Yeast Worm
purine ribonucleoside monophosphate metabolic process	GO:0009167	80	0.096	Yeast Worm
circadian rhythm	GO:0007623	114	0.096	Fly
response to organic cyclic compound	GO:0014070	198	0.096	Rat
oogenesis	GO:0048477	56	0.095	Fly
cellular response to organic cyclic compound	GO:0071407	87	0.092
nitric oxide metabolic process	GO:0046209	25	0.091
kidney development	GO:0001822	213	0.091
embryonic organ morphogenesis	GO:0048562	276	0.087
response to radiation	GO:0009314	165	0.087
actin cytoskeleton organization	GO:0030036	220	0.087	Zebrafish Fly
circadian behavior	GO:0048512	13	0.087	Fly
oocyte construction	GO:0007308	2	0.087	Fly
mrna metabolic process	GO:0016071	84	0.085
response to oxidative stress	GO:0006979	123	0.085
negative regulation of inclusion body assembly	GO:0090084	1	0.084
hindbrain development	GO:0030902	128	0.084
regulation of mrna metabolic process	GO:1903311	43	0.083
organonitrogen compound catabolic process	GO:1901565	264	0.083	Yeast Worm
regulation of stress activated mapk cascade	GO:0032872	69	0.083
positive regulation of reactive oxygen species metabolic process	GO:2000379	11	0.081
nucleobase containing small molecule metabolic process	GO:0055086	352	0.080	Yeast Worm
regulation of cell size	GO:0008361	72	0.079	Rat
protein catabolic process	GO:0030163	221	0.078
er nucleus signaling pathway	GO:0006984	27	0.077
protein dna complex subunit organization	GO:0071824	28	0.077
regulation of neuron projection development	GO:0010975	169	0.076
regulation of nuclear transcribed mrna poly a tail shortening	GO:0060211	4	0.076
nucleoside triphosphate metabolic process	GO:0009141	230	0.075	Yeast Worm
chromatin organization	GO:0006325	206	0.074
positive regulation of organelle organization	GO:0010638	128	0.074	Yeast
neural nucleus development	GO:0048857	22	0.073
protein modification by small protein conjugation	GO:0032446	187	0.073
aromatic compound catabolic process	GO:0019439	286	0.073	Yeast Worm
regulation of neuron death	GO:1901214	134	0.072
positive regulation of rna splicing	GO:0033120	12	0.072
positive regulation of kinase activity	GO:0033674	155	0.071
cellular response to oxidative stress	GO:0034599	76	0.069
regulation of binding	GO:0051098	111	0.069
response to light stimulus	GO:0009416	135	0.067
striated muscle myosin thick filament assembly	GO:0071688	1	0.067	Zebrafish
intracellular receptor signaling pathway	GO:0030522	74	0.067
regulation of apoptotic signaling pathway	GO:2001233	197	0.067
negative regulation of phosphate metabolic process	GO:0045936	184	0.066
female gamete generation	GO:0007292	74	0.066	Fly
microtubule polymerization or depolymerization	GO:0031109	26	0.066
rna splicing via transesterification reactions	GO:0000375	43	0.066
photoreceptor cell differentiation	GO:0046530	52	0.065
membrane organization	GO:0061024	245	0.064
dna replication	GO:0006260	52	0.063	Yeast
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.063	Yeast Worm
mapk cascade	GO:0000165	281	0.063
negative regulation of synapse assembly	GO:0051964	3	0.063
positive regulation of protein import into nucleus	GO:0042307	26	0.061	Rat
positive regulation of growth	GO:0045927	104	0.061
developmental maturation	GO:0021700	193	0.060	Fly
synaptic transmission	GO:0007268	329	0.060
carbohydrate metabolic process	GO:0005975	230	0.060
purine nucleoside monophosphate metabolic process	GO:0009126	81	0.060	Yeast Worm
eye photoreceptor cell differentiation	GO:0001754	41	0.060
protein complex disassembly	GO:0043241	40	0.059
purine nucleoside catabolic process	GO:0006152	205	0.058	Yeast Worm
carbohydrate biosynthetic process	GO:0016051	74	0.058
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.058	Yeast Worm
actin filament polymerization	GO:0030041	44	0.058
t cell mediated immunity	GO:0002456	50	0.057
axon guidance	GO:0007411	141	0.057
lymphocyte proliferation	GO:0046651	164	0.057
detection of stimulus	GO:0051606	84	0.057
urogenital system development	GO:0001655	261	0.057
purine containing compound metabolic process	GO:0072521	311	0.057	Yeast Worm
response to uv a	GO:0070141	1	0.056
gene silencing	GO:0016458	38	0.056
regulation of reactive oxygen species biosynthetic process	GO:1903426	2	0.056
endocytosis	GO:0006897	168	0.056
positive regulation of cell activation	GO:0050867	158	0.055
mitotic spindle organization	GO:0007052	10	0.055	Fly
negative regulation of cell projection organization	GO:0031345	56	0.055
positive regulation of binding	GO:0051099	49	0.054
positive regulation of lymphocyte mediated immunity	GO:0002708	62	0.054
positive regulation of protein transport	GO:0051222	93	0.053	Rat
regulation of cellular component biogenesis	GO:0044087	181	0.053	Rat
reactive oxygen species biosynthetic process	GO:1903409	8	0.053
positive regulation of protein phosphorylation	GO:0001934	242	0.052
protein ubiquitination	GO:0016567	171	0.052
regulation of protein targeting	GO:1903533	61	0.051	Rat
positive regulation of protein import into nucleus translocation	GO:0033160	1	0.050	Rat
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	62	0.050
spindle assembly	GO:0051225	13	0.050
regulation of actin filament length	GO:0030832	45	0.050
cellular lipid metabolic process	GO:0044255	323	0.050
mrna splicing via spliceosome	GO:0000398	43	0.050
neuron death	GO:0070997	154	0.049
response to peptide	GO:1901652	136	0.049
protein localization to membrane	GO:0072657	108	0.049
fatty acid metabolic process	GO:0006631	121	0.049
cellular macromolecule catabolic process	GO:0044265	206	0.049
positive regulation of cell cycle	GO:0045787	92	0.049
protein modification by small protein conjugation or removal	GO:0070647	207	0.049
chemotaxis	GO:0006935	247	0.049
positive regulation of programmed cell death	GO:0043068	218	0.049
negative regulation of rna splicing	GO:0033119	12	0.048
wound healing	GO:0042060	157	0.048
regulation of metal ion transport	GO:0010959	106	0.047
nuclear division	GO:0000280	158	0.047
negative regulation of neuron death	GO:1901215	98	0.047
epidermis development	GO:0008544	187	0.046
regulation of chromosome organization	GO:0033044	83	0.046	Yeast
interleukin 5 secretion	GO:0072603	2	0.046
anatomical structure homeostasis	GO:0060249	145	0.046	Yeast
regulation of cellular component size	GO:0032535	121	0.045	Rat
maintenance of location	GO:0051235	89	0.045
monocarboxylic acid metabolic process	GO:0032787	191	0.045
establishment of protein localization to endoplasmic reticulum	GO:0072599	2	0.044
mrna 3 end processing	GO:0031124	16	0.043
negative regulation of neuron apoptotic process	GO:0043524	92	0.043
nucleoside monophosphate catabolic process	GO:0009125	59	0.043	Yeast Worm
cellular amine metabolic process	GO:0044106	44	0.043
ribonucleoside monophosphate metabolic process	GO:0009161	80	0.043	Yeast Worm
reactive oxygen species metabolic process	GO:0072593	84	0.043
male gamete generation	GO:0048232	285	0.042	Fly
chromatin modification	GO:0016568	187	0.042
intracellular mrna localization	GO:0008298	4	0.042	Fly
proteolysis involved in cellular protein catabolic process	GO:0051603	147	0.042
positive regulation of intracellular transport	GO:0032388	70	0.041	Rat
nitric oxide biosynthetic process	GO:0006809	25	0.041
nucleoside phosphate metabolic process	GO:0006753	338	0.040	Yeast Worm
regulation of neuron apoptotic process	GO:0043523	122	0.040
leukocyte mediated immunity	GO:0002443	174	0.040
glycogen biosynthetic process	GO:0005978	14	0.040
positive regulation of immune response to tumor cell	GO:0002839	6	0.040
mrna processing	GO:0006397	63	0.040
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	88	0.040
spermatid differentiation	GO:0048515	115	0.040
response to inorganic substance	GO:0010035	96	0.039
regulation of circadian sleep wake cycle	GO:0042749	3	0.039	Fly
rrna containing ribonucleoprotein complex export from nucleus	GO:0071428	1	0.038
regeneration	GO:0031099	38	0.038
cerebellum development	GO:0021549	77	0.037
cardiac muscle cell differentiation	GO:0055007	69	0.037
neuron recognition	GO:0008038	25	0.036
sperm motility	GO:0030317	47	0.036
skin development	GO:0043588	220	0.036
determination of adult lifespan	GO:0008340	11	0.036	Worm
digestive tract morphogenesis	GO:0048546	147	0.036
spermatid development	GO:0007286	108	0.036
positive regulation of protein kinase activity	GO:0045860	144	0.035
glucan metabolic process	GO:0044042	32	0.035
response to nutrient levels	GO:0031667	109	0.035
mitotic cytokinesis	GO:0000281	4	0.034
mitotic chromosome condensation	GO:0007076	1	0.034
fatty acid transmembrane transport	GO:1902001	1	0.034
regulation of cell shape	GO:0008360	39	0.034	Fly
meiotic cell cycle process	GO:1903046	77	0.034
cellular response to inorganic substance	GO:0071241	37	0.034
regulation of cell motility	GO:2000145	236	0.033
positive regulation of nitric oxide biosynthetic process	GO:0045429	14	0.033
oxidation reduction process	GO:0055114	342	0.033
regulation of neuron differentiation	GO:0045664	281	0.032
protein export from nucleus	GO:0006611	20	0.032
ear development	GO:0043583	200	0.032
placenta development	GO:0001890	140	0.032	Mouse
neuron projection regeneration	GO:0031102	14	0.032
nitrogen compound transport	GO:0071705	271	0.032
retina development in camera type eye	GO:0060041	119	0.032
muscle tissue development	GO:0060537	308	0.032
regulation of protein binding	GO:0043393	60	0.031
digestive system development	GO:0055123	200	0.031
regulation of intracellular protein transport	GO:0033157	82	0.031	Rat
protein polymerization	GO:0051258	57	0.031
retina homeostasis	GO:0001895	23	0.030
amine metabolic process	GO:0009308	45	0.030
actin polymerization or depolymerization	GO:0008154	54	0.030
ribosomal small subunit biogenesis	GO:0042274	4	0.030
ras protein signal transduction	GO:0007265	77	0.029
dna packaging	GO:0006323	30	0.029
oocyte development	GO:0048599	33	0.029	Fly
cd4 positive alpha beta t cell cytokine production	GO:0035743	4	0.029
cerebellar cortex development	GO:0021695	48	0.029
neuron apoptotic process	GO:0051402	142	0.029
t cell activation	GO:0042110	289	0.029
response to metal ion	GO:0010038	47	0.029
midgut development	GO:0007494	4	0.029
response to decreased oxygen levels	GO:0036293	59	0.028
response to oxygen levels	GO:0070482	62	0.027
cell maturation	GO:0048469	127	0.027	Fly
energy reserve metabolic process	GO:0006112	39	0.027
t helper 2 cell cytokine production	GO:0035745	4	0.027
plasma membrane organization	GO:0007009	90	0.027
positive regulation of neuron differentiation	GO:0045666	141	0.027
interleukin 10 secretion	GO:0072608	4	0.027
multi multicellular organism process	GO:0044706	109	0.027
cilium morphogenesis	GO:0060271	102	0.026
regulation of ral protein signal transduction	GO:0032485	4	0.026
negative regulation of filopodium assembly	GO:0051490	2	0.026
cerebellum morphogenesis	GO:0021587	42	0.026
response to calcium ion	GO:0051592	20	0.026
positive regulation of interleukin 10 production	GO:0032733	12	0.026
negative regulation of cell development	GO:0010721	169	0.026
glucocorticoid receptor signaling pathway	GO:0042921	7	0.026
regulation of protein maturation	GO:1903317	96	0.026
positive regulation of protein binding	GO:0032092	29	0.026
male sex differentiation	GO:0046661	109	0.026
purine ribonucleotide metabolic process	GO:0009150	290	0.026	Yeast Worm
lymphocyte activation involved in immune response	GO:0002285	93	0.025
regulation of endopeptidase activity	GO:0052548	89	0.025
organelle fission	GO:0048285	170	0.025
cardiac muscle tissue development	GO:0048738	130	0.025
regulation of actin filament depolymerization	GO:0030834	13	0.025
cellular response to organonitrogen compound	GO:0071417	145	0.025
neural tube development	GO:0021915	160	0.025
regulation of protein processing	GO:0070613	96	0.025
response to morphine	GO:0043278	9	0.025
nucleus localization	GO:0051647	20	0.025
response to alkaloid	GO:0043279	34	0.025
regulation of neurotransmitter levels	GO:0001505	87	0.024
single organismal cell cell adhesion	GO:0016337	131	0.024
polyamine biosynthetic process	GO:0006596	2	0.024
sleep	GO:0030431	7	0.024	Fly
cation transport	GO:0006812	399	0.024
axonogenesis	GO:0007409	274	0.024
plasma membrane long chain fatty acid transport	GO:0015911	1	0.024
neuron projection guidance	GO:0097485	141	0.024
epithelial cell development	GO:0002064	159	0.024
b cell activation	GO:0042113	161	0.024
negative regulation of cellular amino acid metabolic process	GO:0045763	0	0.024
protein secretion	GO:0009306	111	0.023
response to uv	GO:0009411	44	0.023
telomere maintenance via telomere lengthening	GO:0010833	4	0.023	Yeast
g1 s transition of mitotic cell cycle	GO:0000082	57	0.023
endoplasmic reticulum unfolded protein response	GO:0030968	19	0.023
regulation of lymphocyte activation	GO:0051249	240	0.023
metencephalon development	GO:0022037	89	0.023
positive regulation of protein serine threonine kinase activity	GO:0071902	106	0.022
regulation of actin filament based process	GO:0032970	99	0.022
ribosome biogenesis	GO:0042254	20	0.022
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002460	145	0.022
polyamine transport	GO:0015846	5	0.022
positive regulation of adaptive immune response	GO:0002821	61	0.022
prostaglandin metabolic process	GO:0006693	11	0.022
substantia nigra development	GO:0021762	2	0.022
maturation of lsu rrna	GO:0000470	1	0.022
body morphogenesis	GO:0010171	45	0.021
positive regulation of mrna splicing via spliceosome	GO:0048026	11	0.021
negative regulation of fatty acid transport	GO:2000192	1	0.021
fatty acid biosynthetic process	GO:0006633	41	0.021
generation of precursor metabolites and energy	GO:0006091	103	0.021
cotranslational protein targeting to membrane	GO:0006613	2	0.021
actin filament based movement	GO:0030048	23	0.020
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002822	87	0.020
energy derivation by oxidation of organic compounds	GO:0015980	77	0.020
neurotransmitter transport	GO:0006836	76	0.020
immunoglobulin mediated immune response	GO:0016064	69	0.020
regulation of cell activation	GO:0050865	289	0.020
regulation of vesicle mediated transport	GO:0060627	139	0.020
cellular glucan metabolic process	GO:0006073	32	0.020
anion transport	GO:0006820	177	0.020
adult behavior	GO:0030534	135	0.020
synapse assembly	GO:0007416	56	0.020
muscle cell development	GO:0055001	133	0.020	Zebrafish
positive regulation of apoptotic signaling pathway	GO:2001235	95	0.020
female sex determination	GO:0030237	1	0.020
response to reactive oxygen species	GO:0000302	56	0.019
stress activated mapk cascade	GO:0051403	80	0.019
embryonic eye morphogenesis	GO:0048048	29	0.019
regulation of leukocyte mediated immunity	GO:0002703	104	0.019
positive regulation of ion transport	GO:0043270	65	0.019
sensory perception	GO:0007600	245	0.019
regulation of mrna 3 end processing	GO:0031440	6	0.019
misfolded protein transport	GO:0070843	1	0.019
carbohydrate homeostasis	GO:0033500	128	0.019
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002824	61	0.019
cellular response to dna damage stimulus	GO:0006974	207	0.019
maturation of 5 8s rrna	GO:0000460	1	0.019
circulatory system process	GO:0003013	197	0.019	Rat
endodermal digestive tract morphogenesis	GO:0061031	4	0.018
polysaccharide biosynthetic process	GO:0000271	20	0.018
response to extracellular stimulus	GO:0009991	127	0.018
cell division	GO:0051301	120	0.018
carboxylic acid biosynthetic process	GO:0046394	86	0.018
symbiosis encompassing mutualism through parasitism	GO:0044403	83	0.018
response to unfolded protein	GO:0006986	21	0.018
glycogen metabolic process	GO:0005977	32	0.018
jnk cascade	GO:0007254	72	0.018
eye photoreceptor cell development	GO:0042462	31	0.018
cellular response to granulocyte macrophage colony stimulating factor stimulus	GO:0097011	3	0.018
apoptotic signaling pathway	GO:0097190	306	0.018
regulation of cyclin dependent protein serine threonine kinase activity	GO:0000079	16	0.017
maternal determination of anterior posterior axis embryo	GO:0008358	2	0.017	Fly
regulation of ubiquitin protein ligase activity involved in mitotic cell cycle	GO:0051439	1	0.017

Hsp90aa1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.323
nervous system disease	DOID:863	0.323
central nervous system disease	DOID:331	0.158
joubert syndrome	DOID:0050777	0.049
neurodegenerative disease	DOID:1289	0.021

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