Mus musculus

33 known processes

Map2k5

mitogen-activated protein kinase kinase 5

(Aliases: AI428457,AI324775,Prkmk5,MEK5,Mapkk5)

Map2k5 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
p38mapk cascadeGO:003806640.376
vesicle localizationGO:0051648860.199
neuronal action potentialGO:0019228540.110
regulation of p38mapk cascadeGO:190074430.104
ensheathment of neuronsGO:0007272760.098
mapk cascadeGO:00001652810.090
synaptic transmissionGO:00072683290.082
myelinationGO:0042552740.075
ras protein signal transductionGO:0007265770.074
transmission of nerve impulseGO:0019226760.074
cytoplasmic transportGO:00164822340.072
nuclear divisionGO:00002801580.072
cellular amino acid metabolic processGO:00065201030.071
regulation of cellular amino acid metabolic processGO:000652150.067
small gtpase mediated signal transductionGO:0007264970.066
regulation of mapk cascadeGO:00434082480.066
Rat
negative regulation of cellular amine metabolic processGO:003323910.065
multicellular organismal signalingGO:0035637910.064
meiotic cell cycle processGO:1903046770.063
action potentialGO:0001508780.062
regulation of neuron differentiationGO:00456642810.062
dna metabolic processGO:00062593030.059
regulation of cellular amine metabolic processGO:0033238200.054
organelle fissionGO:00482851700.052
negative regulation of cellular amino acid metabolic processGO:004576300.052
endomembrane system organizationGO:00102561470.050
intracellular protein transportGO:00068862040.049
regulation of protein transportGO:00512231630.049
amine metabolic processGO:0009308450.048
carbohydrate derivative catabolic processGO:19011362310.048
establishment of vesicle localizationGO:0051650810.047
nucleotide metabolic processGO:00091173320.046
regulation of cell projection organizationGO:00313442060.045
organophosphate catabolic processGO:00464342320.044
gtp metabolic processGO:00460391440.044
cytoskeleton dependent intracellular transportGO:0030705500.043
positive regulation of protein modification processGO:00314012990.043
Rat
regulation of engulfment of apoptotic cellGO:190107420.041
cellular lipid metabolic processGO:00442553230.040
engulfment of apoptotic cellGO:004365230.040
regulation of membrane potentialGO:00423911920.040
meiotic nuclear divisionGO:00071261150.039
digestive tract developmentGO:00485651900.039
Rat
regulation of cellular catabolic processGO:00313292420.038
oxidation reduction processGO:00551143420.038
histone modificationGO:00165701590.038
purine nucleotide metabolic processGO:00061633020.038
sensory organ morphogenesisGO:00905962420.038
ribonucleotide metabolic processGO:00092592910.037
camera type eye developmentGO:00430102660.037
regulation of cell cycleGO:00517262810.037
cellular ketone metabolic processGO:0042180840.037
microtubule based movementGO:0007018840.036
axon ensheathmentGO:0008366760.035
male gamete generationGO:00482322850.035
regulation of cellular ketone metabolic processGO:0010565660.035
negative regulation of intracellular signal transductionGO:19025321670.035
regulation of synaptic growth at neuromuscular junctionGO:000858240.035
axon cargo transportGO:0008088330.034
negative regulation of cellular component organizationGO:00511291940.034
wnt signaling pathwayGO:00160551880.033
positive regulation of protein phosphorylationGO:00019342420.033
Rat
establishment of synaptic vesicle localizationGO:0097480570.032
negative regulation of synapse assemblyGO:005196430.032
response to growth factorGO:00708481980.032
Rat
regulation of organelle organizationGO:00330432890.032
spermatogenesisGO:00072832840.032
purine ribonucleoside metabolic processGO:00461282410.031
regulation of ras protein signal transductionGO:00465781140.031
purine nucleoside metabolic processGO:00422782410.031
smoothened signaling pathwayGO:00072241050.031
skeletal system developmentGO:00015013560.031
positive regulation of cellular catabolic processGO:00313311480.031
cell divisionGO:00513011200.030
mitochondrion organizationGO:00070051340.030
aromatic compound catabolic processGO:00194392860.030
cellular amine metabolic processGO:0044106440.029
positive regulation of p38mapk cascadeGO:190074510.029
cytoplasmic mrna processing body assemblyGO:003396260.029
purine containing compound metabolic processGO:00725213110.029
regulation of mitotic cell cycleGO:00073461260.029
cellular carbohydrate metabolic processGO:00442621190.028
carbohydrate metabolic processGO:00059752300.028
gastrulationGO:00073691160.028
Rat
positive regulation of cellular amino acid metabolic processGO:004576430.028
modification dependent protein catabolic processGO:00199411330.028
dephosphorylationGO:00163111290.028
synaptic vesicle localizationGO:0097479590.028
organelle assemblyGO:00709251770.027
protein modification by small protein conjugation or removalGO:00706472070.026
cellular homeostasisGO:00197252400.026
central nervous system neuron differentiationGO:00219531620.026
regulation of secretionGO:00510462740.026
protein autophosphorylationGO:0046777610.026
membrane organizationGO:00610242450.026
glycerolipid metabolic processGO:00464861220.026
mesoderm developmentGO:00074981000.025
anatomical structure homeostasisGO:00602491450.025
stress activated mapk cascadeGO:0051403800.025
positive regulation of stress activated mapk cascadeGO:0032874480.025
i kappab kinase nf kappab signalingGO:0007249850.024
nucleoside phosphate catabolic processGO:19012922220.024
protein catabolic processGO:00301632210.024
organophosphate biosynthetic processGO:00904071220.024
stress activated protein kinase signaling cascadeGO:0031098810.024
peroxisome organizationGO:000703170.024
positive regulation of organelle organizationGO:00106381280.024
regulation of vesicle mediated transportGO:00606271390.023
regulation of cellular component sizeGO:00325351210.023
synaptic vesicle transportGO:0048489570.023
rho protein signal transductionGO:0007266320.023
mitotic cell cycleGO:00002781950.023
regulation of protein localizationGO:00328802310.023
regulation of establishment of protein localizationGO:00702011810.023
microtubule based processGO:00070172360.022
regulation of cellular protein catabolic processGO:1903362610.022
cell fate commitmentGO:00451652100.022
negative regulation of cell developmentGO:00107211690.022
locomotory behaviorGO:00076261950.021
positive regulation of transcription elongation from rna polymerase ii promoterGO:003296820.021
negative regulation of protein modification processGO:00314001630.021
fertilizationGO:00095661270.021
purine containing compound catabolic processGO:00725232130.021
regulation of cell morphogenesis involved in differentiationGO:00107691510.021
heterocycle catabolic processGO:00467002800.021
regulation of intracellular protein transportGO:0033157820.021
generation of precursor metabolites and energyGO:00060911030.021
chromatin modificationGO:00165681870.021
neuron neuron synaptic transmissionGO:0007270690.020
nucleobase containing small molecule metabolic processGO:00550863520.020
transmembrane transportGO:00550854120.020
organonitrogen compound catabolic processGO:19015652640.020
heparin biosynthetic processGO:003021020.020
microtubule based transportGO:0010970500.020
plasma membrane organizationGO:0007009900.020
regulation of stress activated mapk cascadeGO:0032872690.020
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781940.019
developmental growth involved in morphogenesisGO:00605601380.019
cellular chemical homeostasisGO:00550822150.019
positive regulation of phagocytosis engulfmentGO:006010030.019
ribonucleotide catabolic processGO:00092612080.019
spermatid differentiationGO:00485151150.019
regulation of meiotic cell cycleGO:0051445340.019
negative regulation of cellular protein metabolic processGO:00322692470.019
Rat
photoreceptor cell differentiationGO:0046530520.019
telencephalon developmentGO:00215371860.019
regulation of hydrolase activityGO:00513362460.019
Rat
purine ribonucleoside triphosphate catabolic processGO:00092071990.019
positive regulation of intracellular transportGO:0032388700.019
protein oligomerizationGO:0051259670.019
meiotic cell cycleGO:00513211220.018
nitrogen compound transportGO:00717052710.018
positive regulation of cellular amine metabolic processGO:003324050.018
urogenital system developmentGO:00016552610.018
regulation of anatomical structure sizeGO:00900661780.018
ribose phosphate metabolic processGO:00196932910.018
protein maturationGO:00516041760.018
Rat
organelle localizationGO:00516401790.018
nucleoside phosphate metabolic processGO:00067533380.018
regulation of cell cycle processGO:00105641600.018
purine ribonucleoside triphosphate metabolic processGO:00092052200.018
negative regulation of protein phosphorylationGO:00019331260.018
ubiquitin dependent protein catabolic processGO:00065111290.018
negative regulation of phosphorylationGO:00423261660.018
establishment of protein localization to organelleGO:00725941180.018
maintenance of locationGO:0051235890.018
negative regulation of protein metabolic processGO:00512482820.018
Rat
regulation of chromosome organizationGO:0033044830.018
glycerophospholipid metabolic processGO:0006650710.018
protein targetingGO:00066051430.018
regulation of cellular component biogenesisGO:00440871810.018
multicellular organism growthGO:00352641610.017
spermatid developmentGO:00072861080.017
posttranscriptional regulation of gene expressionGO:00106081550.017
purine nucleotide catabolic processGO:00061952110.017
cellular polysaccharide metabolic processGO:0044264380.017
single organism nuclear importGO:1902593950.017
exocytosisGO:00068871210.017
blood vessel morphogenesisGO:00485142850.017
Rat
ribonucleoside metabolic processGO:00091192450.017
organonitrogen compound biosynthetic processGO:19015661920.017
proteolysis involved in cellular protein catabolic processGO:00516031470.017
protein ubiquitinationGO:00165671710.017
heparan sulfate proteoglycan biosynthetic process polysaccharide chain biosynthetic processGO:001501410.017
carbohydrate homeostasisGO:00335001280.017
positive regulation of intracellular protein transportGO:0090316420.017
regulation of neuron projection developmentGO:00109751690.017
glycosyl compound catabolic processGO:19016582060.016
positive regulation of nucleotide metabolic processGO:00459811140.016
macromolecule catabolic processGO:00090572810.016
sulfur compound biosynthetic processGO:0044272370.016
negative regulation of cell cycleGO:00457861230.016
retina morphogenesis in camera type eyeGO:0060042450.016
regulation of transmembrane transportGO:00347621280.016
peptidyl lysine modificationGO:0018205770.016
energy derivation by oxidation of organic compoundsGO:0015980770.016
protein importGO:00170381010.016
autophagyGO:0006914450.016
blood circulationGO:00080151950.016
peptidyl threonine modificationGO:0018210310.016
positive regulation of ras gtpase activityGO:0032320650.016
homeostasis of number of cellsGO:00488722100.016
renal system developmentGO:00720012250.016
positive regulation of macroautophagyGO:001623930.016
regulation of secretion by cellGO:19035302490.016
small molecule catabolic processGO:0044282710.016
cytokine productionGO:00018163190.016
Rat
regulation of kinase activityGO:00435492490.016
Rat
ribonucleoprotein complex subunit organizationGO:0071826280.016
lung developmentGO:00303241640.016
cellular nitrogen compound catabolic processGO:00442702800.016
circulatory system processGO:00030131970.015
gtp catabolic processGO:00061841430.015
germ cell developmentGO:00072811850.015
epithelial cell proliferationGO:00506731740.015
Rat
establishment of meiotic spindle orientationGO:005129610.015
respiratory tube developmentGO:00303231670.015
defense response to other organismGO:00985421970.015
glycerolipid biosynthetic processGO:0045017500.015
dendrite developmentGO:00163581150.015
regulation of nucleocytoplasmic transportGO:0046822730.015
skin developmentGO:00435882200.015
cellular macromolecule catabolic processGO:00442652060.015
nucleoside catabolic processGO:00091642060.015
lipid localizationGO:00108761260.015
sulfur compound metabolic processGO:00067901000.015
protein acylationGO:0043543640.015
regulation of cell motilityGO:20001452360.015
Rat
cation transmembrane transportGO:00986552660.015
positive regulation of cell developmentGO:00107202370.015
ribonucleoside triphosphate metabolic processGO:00091992200.014
heparan sulfate proteoglycan biosynthetic processGO:001501280.014
regulation of transferase activityGO:00513382630.014
Rat
positive regulation of triglyceride lipase activityGO:006136530.014
cellular response to organonitrogen compoundGO:00714171450.014
protein localization to membraneGO:00726571080.014
meiosis iGO:0007127600.014
response to monosaccharideGO:0034284670.014
protein polymerizationGO:0051258570.014
synapse organizationGO:00508081250.014
negative regulation of growthGO:0045926990.014
regulation of purine nucleotide metabolic processGO:19005421690.014
negative regulation of phosphorus metabolic processGO:00105631840.014
regulation of nucleotide metabolic processGO:00061401690.014
rna processingGO:00063961050.014
glycosyl compound metabolic processGO:19016572460.014
myeloid cell differentiationGO:00300992330.014
striated muscle tissue developmentGO:00147062930.014
glucose homeostasisGO:00425931280.014
lipid modificationGO:0030258650.014
ribonucleoside catabolic processGO:00424542060.014
epithelial tube morphogenesisGO:00605623030.014
cell adhesionGO:00071553290.014
Rat
response to nutrient levelsGO:00316671090.013
proteasomal protein catabolic processGO:0010498980.013
muscle tissue developmentGO:00605373080.013
gliogenesisGO:00420631410.013
regulation of endocytosisGO:0030100690.013
protein localization to organelleGO:00333651850.013
regulation of proteolysis involved in cellular protein catabolic processGO:1903050560.013
retina development in camera type eyeGO:00600411190.013
glycerophospholipid biosynthetic processGO:0046474320.013
positive regulation of mapk cascadeGO:00434101700.013
Rat
guanosine containing compound metabolic processGO:19010681440.013
digestive tract morphogenesisGO:00485461470.013
Rat
regulation of intracellular transportGO:00323861590.013
microtubule cytoskeleton organizationGO:00002261570.013
negative regulation of neuron differentiationGO:00456651010.013
axonogenesisGO:00074092740.013
regulation of asymmetric cell divisionGO:000978640.013
histone deubiquitinationGO:001657820.013
proteoglycan biosynthetic processGO:0030166200.013
mitochondrion distributionGO:004831140.013
polysaccharide metabolic processGO:0005976390.013
pharynx developmentGO:006046510.013
establishment or maintenance of cell polarityGO:0007163860.013
adult behaviorGO:00305341350.013
angiogenesisGO:00015252010.013
Rat
response to organonitrogen compoundGO:00102432460.013
immune effector processGO:00022523210.013
negative regulation of wnt signaling pathwayGO:0030178730.013
developmental cell growthGO:0048588840.013
nucleocytoplasmic transportGO:00069131390.013
regulation of cell divisionGO:0051302760.012
stem cell developmentGO:00488642190.012
adult locomotory behaviorGO:0008344910.012
hormone secretionGO:00468791280.012
innate immune responseGO:00450871570.012
male genitalia morphogenesisGO:004880840.012
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071692470.012
female gamete generationGO:0007292740.012
regulation of lymphocyte proliferationGO:00506701170.012
positive regulation of engulfment of apoptotic cellGO:190107610.012
establishment of protein localization to membraneGO:0090150540.012
hindbrain developmentGO:00309021280.012
regulation of autophagyGO:0010506300.012
nuclear transportGO:00511691390.012
peptidyl amino acid modificationGO:00181933360.012
nucleoside phosphate biosynthetic processGO:1901293790.012
lateral inhibitionGO:004633110.012
response to organic cyclic compoundGO:00140701980.012
regulation of t cell activationGO:00508631700.012
glial cell differentiationGO:00100011310.012
ribonucleoside triphosphate catabolic processGO:00092031990.012
methylationGO:00322591340.012
localization within membraneGO:005166840.012
oocyte anterior posterior axis specificationGO:000731420.012
camera type eye photoreceptor cell differentiationGO:0060219150.012
regulation of homeostatic processGO:00328441820.012
ion transmembrane transportGO:00342203610.012
purine ribonucleotide catabolic processGO:00091542080.012
central nervous system neuron developmentGO:0021954670.012
protein import into nucleusGO:0006606950.012
regulation of hormone levelsGO:00108172110.012
cellular response to growth factor stimulusGO:00713631970.012
Rat
learning or memoryGO:00076111480.011
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:00900921120.011
regulation of purine nucleotide catabolic processGO:00331211220.011
cytokine mediated signaling pathwayGO:00192211150.011
organic hydroxy compound metabolic processGO:19016152030.011
regionalizationGO:00030023370.011
nucleoside triphosphate metabolic processGO:00091412300.011
habituationGO:004695930.011
positive regulation of purine nucleotide catabolic processGO:0033123880.011
cerebellum developmentGO:0021549770.011
synapse assemblyGO:0007416560.011
regulation of myeloid cell differentiationGO:0045637960.011
molting cycleGO:0042303900.011
Worm
single fertilizationGO:0007338820.011
cellular response to dna damage stimulusGO:00069742070.011
dna alkylationGO:0006305430.011
phospholipid metabolic processGO:0006644870.011
positive regulation of cell motilityGO:20001471160.011
phagosome maturationGO:009038240.011
nucleoside monophosphate metabolic processGO:0009123850.011
regulation of cell sizeGO:0008361720.011
alpha amino acid metabolic processGO:1901605590.011
multicellular organismal homeostasisGO:00488711640.011
regulation of cytoskeleton organizationGO:00514931220.011
regulation of protein processingGO:0070613960.011
Rat
ossificationGO:00015032160.011
cellular response to external stimulusGO:0071496880.011
chemotaxisGO:00069352470.011
protein localization to plasma membraneGO:0072659570.011
peptide secretionGO:00027901140.011
guanosine containing compound catabolic processGO:19010691440.011
regulation of system processGO:00440572000.011
response to extracellular stimulusGO:00099911270.011
glycoprotein metabolic processGO:00091001160.011
monocarboxylic acid metabolic processGO:00327871910.011
development of primary sexual characteristicsGO:00451371430.011
Worm
cognitionGO:00508901490.011
cardiac chamber morphogenesisGO:0003206930.011
positive regulation of t cell activationGO:00508701010.010
embryonic appendage morphogenesisGO:00351131260.010
peptidyl serine modificationGO:0018209830.010
macroautophagyGO:0016236210.010
morphogenesis of a branching epitheliumGO:00611381930.010
positive regulation of kinase activityGO:00336741550.010
Rat
peptide hormone secretionGO:00300721090.010
energy reserve metabolic processGO:0006112390.010
cellular protein catabolic processGO:00442571550.010
positive regulation of hydrolase activityGO:00513451480.010
nuclear importGO:0051170950.010
negative regulation of molecular functionGO:00440922580.010
Rat
cell type specific apoptotic processGO:00972852680.010
early endosome to late endosome transportGO:004502220.010
oogenesisGO:0048477560.010
purine ribonucleotide metabolic processGO:00091502900.010
positive regulation of nucleotide catabolic processGO:0030813880.010
oocyte constructionGO:000730820.010
kidney developmentGO:00018222130.010
positive regulation of apoptotic cell clearanceGO:200042730.010
synaptic transmission gabaergicGO:0051932190.010
positive regulation of nucleoside metabolic processGO:0045979910.010
regulation of protein modification by small protein conjugation or removalGO:1903320570.010
regulation of leukocyte differentiationGO:19021051590.010

Map2k5 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
nervous system diseaseDOID:86300.074
disease of anatomical entityDOID:700.074
neuropathyDOID:87000.043
neuromuscular diseaseDOID:44000.042
disease of metabolismDOID:001466700.024
charcot marie tooth diseaseDOID:1059500.024
central nervous system diseaseDOID:33100.017
inherited metabolic disorderDOID:65500.011
musculoskeletal system diseaseDOID:1700.011
connective tissue diseaseDOID:6500.011
brain diseaseDOID:93600.011