Mus musculus

22 known processes

Map2k4

mitogen-activated protein kinase kinase 4

(Aliases: Sek1,PRKMK4,MEK4,JNKK1,MKK4,Serk1)

Map2k4 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
protein modification by small protein conjugation or removalGO:00706472070.644
protein modification by small protein conjugationGO:00324461870.483
cellular protein catabolic processGO:00442571550.405
cellular macromolecule catabolic processGO:00442652060.349
regulation of transferase activityGO:00513382630.285
Zebrafish Mouse Rat Worm Fly
regulation of protein kinase activityGO:00458592320.268
Zebrafish Mouse Rat Worm Fly
proteolysis involved in cellular protein catabolic processGO:00516031470.264
modification dependent protein catabolic processGO:00199411330.263
regulation of mapk cascadeGO:00434082480.245
Zebrafish Mouse Rat Worm Fly
ras protein signal transductionGO:0007265770.243
protein localization to organelleGO:00333651850.233
protein ubiquitinationGO:00165671710.218
establishment of protein localization to organelleGO:00725941180.217
macromolecule catabolic processGO:00090572810.215
regulation of kinase activityGO:00435492490.209
Zebrafish Mouse Rat Worm Fly
protein catabolic processGO:00301632210.196
intracellular protein transportGO:00068862040.195
cytoplasmic transportGO:00164822340.191
regulation of cellular response to stressGO:00801351590.191
Zebrafish Mouse Rat Fly
positive regulation of protein modification processGO:00314012990.187
Zebrafish Mouse Rat Worm Fly
peptidyl serine modificationGO:0018209830.180
small gtpase mediated signal transductionGO:0007264970.179
muscle cell differentiationGO:00426922610.176
Rat
negative regulation of molecular functionGO:00440922580.170
jnk cascadeGO:0007254720.166
Zebrafish Mouse Rat Fly
mitochondrion organizationGO:00070051340.163
heterocycle catabolic processGO:00467002800.159
regulation of stress activated mapk cascadeGO:0032872690.153
Zebrafish Mouse Rat Fly
positive regulation of kinase activityGO:00336741550.151
Zebrafish Mouse Rat Worm Fly
regulation of protein serine threonine kinase activityGO:00719001570.147
Zebrafish Mouse Rat Worm Fly
regulation of proteolysisGO:00301621640.145
autophagyGO:0006914450.142
peptidyl amino acid modificationGO:00181933360.132
actin cytoskeleton organizationGO:00300362200.131
protein targetingGO:00066051430.129
regulation of establishment of protein localizationGO:00702011810.120
regulation of cellular catabolic processGO:00313292420.115
negative regulation of intracellular signal transductionGO:19025321670.114
mitochondrion distributionGO:004831140.114
negative regulation of cellular component organizationGO:00511291940.113
response to osmotic stressGO:0006970210.110
negative regulation of protein modification processGO:00314001630.108
negative regulation of ripoptosome assembly involved in necroptotic processGO:190244330.106
synaptic transmissionGO:00072683290.103
Worm
regulation of jnk cascadeGO:0046328620.100
Zebrafish Mouse Rat Fly
cellular response to growth factor stimulusGO:00713631970.099
organic cyclic compound catabolic processGO:19013612950.098
protein import into nucleusGO:0006606950.095
ubiquitin dependent protein catabolic processGO:00065111290.094
cation transportGO:00068123990.093
mapk cascadeGO:00001652810.090
mitotic cell cycleGO:00002781950.090
positive regulation of protein kinase activityGO:00458601440.090
Zebrafish Mouse Rat Worm Fly
negative regulation of protein phosphorylationGO:00019331260.089
protein importGO:00170381010.089
p38mapk cascadeGO:003806640.088
peptidyl serine phosphorylationGO:0018105740.087
positive regulation of intracellular protein transportGO:0090316420.087
membrane organizationGO:00610242450.085
dephosphorylationGO:00163111290.085
regulation of organelle organizationGO:00330432890.082
protein autophosphorylationGO:0046777610.082
regulation of protein localizationGO:00328802310.081
positive regulation of cell deathGO:00109422240.080
Rat
apoptotic mitochondrial changesGO:0008637480.079
wnt signaling pathwayGO:00160551880.079
regulation of intracellular protein transportGO:0033157820.076
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781940.076
regulation of map kinase activityGO:00434051200.076
Zebrafish Mouse Rat Worm Fly
regulation of jun kinase activityGO:0043506400.076
Zebrafish Mouse Rat Fly
positive regulation of transferase activityGO:00513471670.075
Zebrafish Mouse Rat Worm Fly
myotube differentiationGO:00149021050.074
positive regulation of programmed cell deathGO:00430682180.073
Rat
purine nucleotide metabolic processGO:00061633020.073
regulation of apoptotic signaling pathwayGO:20012331970.073
response to growth factorGO:00708481980.073
muscle tissue developmentGO:00605373080.072
Rat
positive regulation of transcription elongation from rna polymerase ii promoterGO:003296820.071
positive regulation of intracellular transportGO:0032388700.071
cellular amino acid metabolic processGO:00065201030.070
endocytosisGO:00068971680.070
dna metabolic processGO:00062593030.070
Rat
cellular protein complex assemblyGO:00436231160.069
regulation of cellular component sizeGO:00325351210.068
protein oligomerizationGO:0051259670.067
single organism nuclear importGO:1902593950.065
positive regulation of protein transportGO:0051222930.065
regulation of anatomical structure sizeGO:00900661780.065
engulfment of apoptotic cellGO:004365230.065
aromatic compound catabolic processGO:00194392860.065
striated muscle cell developmentGO:00550021250.064
Rat
protein ubiquitination involved in ubiquitin dependent protein catabolic processGO:0042787250.063
positive regulation of apoptotic processGO:00430652170.063
Rat
regulation of cellular component biogenesisGO:00440871810.061
positive regulation of cellular amino acid metabolic processGO:004576430.059
digestive tract morphogenesisGO:00485461470.059
nucleocytoplasmic transportGO:00069131390.059
organelle localizationGO:00516401790.059
regulation of intracellular transportGO:00323861590.059
axonogenesisGO:00074092740.058
ribose phosphate metabolic processGO:00196932910.057
protein polyubiquitinationGO:0000209330.057
nucleoside phosphate catabolic processGO:19012922220.056
regulation of secretionGO:00510462740.056
activation of nf kappab inducing kinase activityGO:000725040.056
regulation of vesicle mediated transportGO:00606271390.055
positive regulation of jun kinase activityGO:0043507300.055
Zebrafish Mouse Rat Fly
positive regulation of mapk cascadeGO:00434101700.054
Zebrafish Mouse Rat Worm Fly
purine ribonucleotide metabolic processGO:00091502900.053
nuclear transportGO:00511691390.053
negative regulation of phosphate metabolic processGO:00459361840.053
nucleoside catabolic processGO:00091642060.053
regulation of nucleocytoplasmic transportGO:0046822730.053
compound eye developmentGO:004874910.053
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071692470.052
regulation of cell migrationGO:00303342190.052
purine nucleoside metabolic processGO:00422782410.051
regulation of ras protein signal transductionGO:00465781140.051
organelle fissionGO:00482851700.051
regulation of wnt signaling pathwayGO:00301111230.051
digestive tract developmentGO:00485651900.051
carbohydrate metabolic processGO:00059752300.051
nucleotide metabolic processGO:00091173320.051
positive regulation of protein localization to nucleusGO:1900182300.051
amine metabolic processGO:0009308450.050
regulation of cell cycleGO:00517262810.050
striated muscle tissue developmentGO:00147062930.050
Rat
regulation of neuron differentiationGO:00456642810.049
positive regulation of cellular amine metabolic processGO:003324050.049
vacuole organizationGO:0007033380.049
modification dependent macromolecule catabolic processGO:00436321330.049
ribonucleotide metabolic processGO:00092592910.048
regulation of protein import into nucleusGO:0042306520.047
histone modificationGO:00165701590.047
regulation of cellular amino acid metabolic processGO:000652150.047
guanosine containing compound catabolic processGO:19010691440.047
necrotic cell deathGO:0070265300.047
cell divisionGO:00513011200.047
meiotic cell cycleGO:00513211220.047
regulation of cytoplasmic transportGO:19036491120.046
regulation of synaptic growth at neuromuscular junctionGO:000858240.046
nucleobase containing small molecule metabolic processGO:00550863520.046
regionalizationGO:00030023370.046
Zebrafish
i kappab kinase nf kappab signalingGO:0007249850.046
regulation of multi organism processGO:00439001110.045
cellular ketone metabolic processGO:0042180840.045
proteasomal protein catabolic processGO:0010498980.045
negative regulation of phosphorus metabolic processGO:00105631840.045
organonitrogen compound catabolic processGO:19015652640.045
phagocytosisGO:0006909660.045
positive regulation of protein phosphorylationGO:00019342420.045
Zebrafish Mouse Rat Worm Fly
positive regulation of dna templated transcription elongationGO:003278620.044
response to organonitrogen compoundGO:00102432460.044
nucleoside phosphate metabolic processGO:00067533380.044
cellular response to abiotic stimulusGO:0071214560.044
Human
ribonucleoside triphosphate metabolic processGO:00091992200.044
positive regulation of cellular component biogenesisGO:0044089940.043
regulation of cell motilityGO:20001452360.043
nuclear importGO:0051170950.043
cellular response to external stimulusGO:0071496880.043
Human
wound healingGO:00420601570.043
regulation of hydrolase activityGO:00513362460.043
glycosyl compound metabolic processGO:19016572460.042
regulation of protein targetingGO:1903533610.042
regulation of cell cycle processGO:00105641600.042
ribonucleoside metabolic processGO:00091192450.042
positive regulation of proteolysisGO:0045862850.042
establishment or maintenance of cytoskeleton polarityGO:003095220.042
response to organic cyclic compoundGO:00140701980.041
activation of mapkk activityGO:0000186150.041
protein polymerizationGO:0051258570.041
positive regulation of nucleocytoplasmic transportGO:0046824300.041
microtubule based movementGO:0007018840.041
protein maturationGO:00516041760.041
digestive system developmentGO:00551232000.041
exocytosisGO:00068871210.041
nucleoside metabolic processGO:00091162460.041
muscle cell developmentGO:00550011330.040
Rat
negative regulation of phosphorylationGO:00423261660.040
gtp metabolic processGO:00460391440.039
canonical wnt signaling pathwayGO:00600701300.039
purine containing compound metabolic processGO:00725213110.038
homeostasis of number of cellsGO:00488722100.038
vesicle localizationGO:0051648860.038
response to uvGO:0009411440.038
regulation of engulfment of apoptotic cellGO:190107420.038
negative regulation of protein serine threonine kinase activityGO:0071901490.037
establishment of vesicle localizationGO:0051650810.037
mitotic cell cycle processGO:19030471590.037
peptidyl threonine modificationGO:0018210310.036
protein processingGO:00164851630.036
regulation of system processGO:00440572000.036
regulation of cellular ketone metabolic processGO:0010565660.036
positive regulation of organelle organizationGO:00106381280.036
purine nucleoside catabolic processGO:00061522050.036
regulation of protein localization to nucleusGO:1900180600.036
regulation of purine nucleotide metabolic processGO:19005421690.036
meiotic nuclear divisionGO:00071261150.035
muscle system processGO:00030121410.035
Mouse Rat
rhythmic processGO:00485111740.035
activation of jnkk activityGO:000725630.035
positive regulation of protein import into nucleusGO:0042307260.035
activation of jun kinase activityGO:0007257150.035
Zebrafish Mouse Rat Fly
carbohydrate derivative catabolic processGO:19011362310.035
muscle contractionGO:00069361010.035
Mouse
regulation of endopeptidase activityGO:0052548890.034
positive regulation of synaptic growth at neuromuscular junctionGO:004588710.034
response to oxidative stressGO:00069791230.034
cognitionGO:00508901490.034
osmosensory signaling pathwayGO:000723110.034
olfactory learningGO:000835520.033
lipid modificationGO:0030258650.033
microtubule based processGO:00070172360.033
purine containing compound catabolic processGO:00725232130.033
actin filament organizationGO:00070151130.033
regulation of cell projection organizationGO:00313442060.033
regulation of actin polymerization or depolymerizationGO:0008064450.033
positive regulation of map kinase activityGO:0043406840.033
Zebrafish Mouse Rat Worm Fly
response to transforming growth factor betaGO:0071559880.033
establishment or maintenance of microtubule cytoskeleton polarityGO:003095110.033
purine nucleoside triphosphate metabolic processGO:00091442260.033
regulation of protein transportGO:00512231630.032
transforming growth factor beta receptor signaling pathwayGO:0007179710.032
purine ribonucleoside metabolic processGO:00461282410.032
nitrogen compound transportGO:00717052710.032
amide transportGO:00428861380.032
membrane fusionGO:0061025380.032
positive regulation of cytoplasmic transportGO:1903651400.032
hyperosmotic responseGO:000697240.032
cellular lipid metabolic processGO:00442553230.032
purine ribonucleoside triphosphate catabolic processGO:00092071990.032
chromatin modificationGO:00165681870.031
ribonucleoside triphosphate catabolic processGO:00092031990.031
blood vessel morphogenesisGO:00485142850.031
purine ribonucleotide catabolic processGO:00091542080.031
skeletal muscle fiber developmentGO:0048741580.031
nucleoside triphosphate metabolic processGO:00091412300.031
stress activated mapk cascadeGO:0051403800.031
Zebrafish Mouse Rat Fly
stem cell differentiationGO:00488632680.031
cellular response to arsenic containing substanceGO:007124340.030
neuron deathGO:00709971540.030
Rat
stress activated protein kinase signaling cascadeGO:0031098810.029
Zebrafish Mouse Rat Fly
response to peptideGO:19016521360.029
peptide transportGO:00158331330.029
positive regulation of jnk cascadeGO:0046330460.029
Zebrafish Mouse Rat Fly
locomotory behaviorGO:00076261950.029
respiratory system developmentGO:00605411900.029
gastrulationGO:00073691160.028
negative regulation of wnt signaling pathwayGO:0030178730.028
meiotic cell cycle processGO:1903046770.028
ion transmembrane transportGO:00342203610.028
skeletal system morphogenesisGO:00487052030.027
cellular nitrogen compound catabolic processGO:00442702800.027
regulation of cellular amine metabolic processGO:0033238200.027
negative regulation of cellular protein metabolic processGO:00322692470.027
developmental maturationGO:00217001930.027
Fly
skeletal muscle organ developmentGO:00605381630.027
epithelial tube morphogenesisGO:00605623030.027
guanosine containing compound metabolic processGO:19010681440.027
rho protein signal transductionGO:0007266320.027
inositol phosphate catabolic processGO:007154540.027
lateral inhibitionGO:004633110.027
synapse organizationGO:00508081250.027
Worm
peptidyl threonine phosphorylationGO:0018107310.026
gtp catabolic processGO:00061841430.026
negative regulation of transferase activityGO:0051348850.026
oogenesisGO:0048477560.026
oocyte axis specificationGO:000730920.026
intrinsic apoptotic signaling pathwayGO:00971931320.026
female gamete generationGO:0007292740.026
microtubule based transportGO:0010970500.026
positive regulation of cellular catabolic processGO:00313311480.026
negative regulation of kinase activityGO:0033673810.026
cellular ion homeostasisGO:00068731650.026
leukocyte differentiationGO:00025213420.026
regulation of membrane potentialGO:00423911920.026
negative regulation of cell proliferationGO:00082852960.025
regulation of extrinsic apoptotic signaling pathwayGO:2001236770.025
ribonucleotide catabolic processGO:00092612080.025
chromatin organizationGO:00063252060.025
stem cell developmentGO:00488642190.025
establishment of organelle localizationGO:00516561220.025
organophosphate catabolic processGO:00464342320.025
apoptotic signaling pathwayGO:00971903060.025
regulation of peptide transportGO:0090087910.025
establishment of protein localization to membraneGO:0090150540.025
macroautophagyGO:0016236210.025
maintenance of locationGO:0051235890.024
cellular response to transforming growth factor beta stimulusGO:0071560880.024
neuronal action potentialGO:0019228540.024
monocarboxylic acid metabolic processGO:00327871910.024
negative regulation of apoptotic signaling pathwayGO:20012341040.024
regulation of neuron deathGO:19012141340.024
Rat
neuron projection extensionGO:1990138640.024
purine nucleotide catabolic processGO:00061952110.024
germ cell developmentGO:00072811850.024
golgi localizationGO:005164540.024
cation homeostasisGO:00550802120.024
pole plasm assemblyGO:000731520.024
regulation of endocytosisGO:0030100690.023
positive regulation of apoptotic signaling pathwayGO:2001235950.023
cellular amine metabolic processGO:0044106440.023
symbiosis encompassing mutualism through parasitismGO:0044403830.023
nucleoside triphosphate catabolic processGO:00091432050.023
circadian rhythmGO:00076231140.023
regulation of secretion by cellGO:19035302490.023
cellular component assembly involved in morphogenesisGO:00109271390.023
positive regulation of cytoskeleton organizationGO:0051495490.023
purine nucleoside triphosphate catabolic processGO:00091462030.023
regulation of defense responseGO:00313472330.023
cellular carbohydrate metabolic processGO:00442621190.023
intra golgi vesicle mediated transportGO:000689110.022
ribonucleoside catabolic processGO:00424542060.022
cardiac muscle tissue developmentGO:00487381300.022
Rat
syncytium formationGO:0006949430.022
regulation of proteolysis involved in cellular protein catabolic processGO:1903050560.022
organelle assemblyGO:00709251770.022
purine ribonucleoside triphosphate metabolic processGO:00092052200.022
negative regulation of phagocytosisGO:005076540.022
positive regulation of protein serine threonine kinase activityGO:00719021060.022
Zebrafish Mouse Rat Worm Fly
germline cell cycle switching mitotic to meiotic cell cycleGO:005172910.022
nuclear divisionGO:00002801580.022
posttranscriptional regulation of gene expressionGO:00106081550.022
Worm
regulation of ion transportGO:00432692150.022
lymphocyte proliferationGO:00466511640.022
positive regulation of cell developmentGO:00107202370.022
angiogenesisGO:00015252010.022
gland developmentGO:00487323300.021
cytoskeleton dependent intracellular transportGO:0030705500.021
plasma membrane organizationGO:0007009900.021
response to molecule of bacterial originGO:00022371430.021
regulation of protein maturationGO:1903317960.021
transmembrane transportGO:00550854120.021
negative regulation of map kinase activityGO:0043407340.021
retrograde transport endosome to golgiGO:004214720.021
negative regulation of nervous system developmentGO:00519611560.021
cellular homeostasisGO:00197252400.021
leukocyte mediated immunityGO:00024431740.021
fibroblast growth factor receptor signaling pathwayGO:0008543460.021
regulation of nucleotide catabolic processGO:00308111220.020
positive regulation of stress activated mapk cascadeGO:0032874480.020
Zebrafish Mouse Rat Fly
regulation of protein processingGO:0070613960.020
protein localization to nucleusGO:00345041210.020
multicellular organismal signalingGO:0035637910.020
meiosis iGO:0007127600.020
synaptic vesicle localizationGO:0097479590.020
immune effector processGO:00022523210.020
myeloid cell differentiationGO:00300992330.020
cell growthGO:00160491300.020
Rat
regulation of response to woundingGO:19030341890.020
positive regulation of growthGO:00459271040.020
response to reactive oxygen speciesGO:0000302560.020
purine ribonucleoside catabolic processGO:00461302050.020
learning or memoryGO:00076111480.020
mitochondrion transport along microtubuleGO:004749730.020
negative regulation of hydrolase activityGO:0051346710.020
positive regulation of macroautophagyGO:001623930.020
cartilage developmentGO:00512161400.020
regulation of transcription factor import into nucleusGO:0042990240.019
circulatory system processGO:00030131970.019
Mouse
positive regulation of nervous system developmentGO:00519622210.019
covalent chromatin modificationGO:00165691630.019
cellular response to osmotic stressGO:007147070.019
positive regulation of protein complex assemblyGO:0031334450.019
regulation of adaptive immune responseGO:0002819900.019
mesoderm developmentGO:00074981000.019
response to nutrient levelsGO:00316671090.019
regulation of neuron projection developmentGO:00109751690.019
determination of left right symmetryGO:0007368800.019
regulation of mitotic cell cycleGO:00073461260.019
regulation of striated muscle cell differentiationGO:0051153810.019
transmission of nerve impulseGO:0019226760.019
adult behaviorGO:00305341350.019
myoblast differentiation involved in skeletal muscle regenerationGO:001483530.019
epithelial cell proliferationGO:00506731740.019
cellular response to molecule of bacterial originGO:0071219830.018
regulation of erk1 and erk2 cascadeGO:0070372710.018
asymmetric neuroblast divisionGO:005505910.018
oocyte constructionGO:000730820.018
monosaccharide metabolic processGO:00059961060.018
cellular response to peptide hormone stimulusGO:0071375920.018
muscle fiber developmentGO:0048747760.018
regulation of myeloid cell differentiationGO:0045637960.018
regulation of nucleotide metabolic processGO:00061401690.018
cellular response to cadmium ionGO:007127630.018
cellular response to dna damage stimulusGO:00069742070.018
lung developmentGO:00303241640.018
regulation of cellular protein catabolic processGO:1903362610.018
lymphocyte homeostasisGO:0002260640.018
camera type eye developmentGO:00430102660.018
lipid localizationGO:00108761260.018
peptide metabolic processGO:0006518460.018
regulation of rho protein signal transductionGO:0035023710.018
cell adhesionGO:00071553290.018
regulation of excitatory postsynaptic membrane potentialGO:0060079410.017
myotube cell developmentGO:0014904600.017
cellular response to oxidative stressGO:0034599760.017
positive regulation of hydrolase activityGO:00513451480.017
cellular response to nitric oxideGO:007173240.017
regulation of circadian rhythmGO:0042752580.017
formation of primary germ layerGO:0001704770.017
regulation of peptidase activityGO:0052547960.017
morphogenesis of embryonic epitheliumGO:00163311590.017
proteasome mediated ubiquitin dependent protein catabolic processGO:0043161880.017
negative regulation of protein maturationGO:1903318790.017
action potentialGO:0001508780.017
defense response to other organismGO:00985421970.017
regulation of muscle tissue developmentGO:1901861970.017
membrane invaginationGO:0010324170.017
negative regulation of cell cycleGO:00457861230.017
cellular amide metabolic processGO:0043603580.017
negative regulation of jun kinase activityGO:004350890.017
neuron apoptotic processGO:00514021420.017
Rat
regulation of transmembrane transportGO:00347621280.017
negative regulation of necroptotic processGO:006054690.017
negative regulation of cell developmentGO:00107211690.017
endodermal cell fate specificationGO:000171440.017
regulation of ion transmembrane transportGO:00347651190.017
regulation of protein catabolic processGO:00421761080.017
response to lipopolysaccharideGO:00324961280.017
regulation of cytoskeleton organizationGO:00514931220.017
regulation of myotube differentiationGO:0010830620.016
cellular response to inorganic substanceGO:0071241370.016
regulation of cell adhesionGO:00301551540.016
negative regulation of cytoskeleton organizationGO:0051494360.016
positive regulation of erk1 and erk2 cascadeGO:0070374470.016
multicellular organism growthGO:00352641610.016
negative regulation of mapk cascadeGO:0043409650.016
establishment of mitochondrion localizationGO:005165440.016
regulation of ras gtpase activityGO:0032318880.016
nucleotide catabolic processGO:00091662170.016
ameboidal type cell migrationGO:00016671280.016
regulation of purine nucleotide catabolic processGO:00331211220.016
g protein coupled receptor signaling pathwayGO:00071862430.016
negative regulation of neuron apoptotic processGO:0043524920.016
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:0002822870.016
regulation of canonical wnt signaling pathwayGO:0060828820.016
glycosyl compound catabolic processGO:19016582060.016
regulation of hormone levelsGO:00108172110.016
development of primary sexual characteristicsGO:00451371430.016
dna repairGO:00062811070.016
inorganic ion transmembrane transportGO:00986602340.016
cellular response to lipidGO:00713961450.016
response to inorganic substanceGO:0010035960.016
oxidation reduction processGO:00551143420.016
regulation of leukocyte mediated immunityGO:00027031040.016
axon ensheathmentGO:0008366760.016
regulation of cell activationGO:00508652890.016
positive regulation of necrotic cell deathGO:001094010.016
response to peptide hormoneGO:00434341270.016
dendrite developmentGO:00163581150.016
positive regulation of macrophage derived foam cell differentiationGO:001074440.016
calcium ion homeostasisGO:00550741270.016
cell type specific apoptotic processGO:00972852680.015
Rat
organonitrogen compound biosynthetic processGO:19015661920.015
protein modification by small protein removalGO:0070646210.015
cellular response to biotic stimulusGO:0071216920.015
cellular response to organonitrogen compoundGO:00714171450.015
skeletal myofibril assemblyGO:001486640.015
regulation of actin filament lengthGO:0030832450.015
maternal determination of anterior posterior axis embryoGO:000835820.015
cellular response to hormone stimulusGO:00328701500.015
organelle disassemblyGO:190300820.015
negative regulation of necrotic cell deathGO:0060547110.015
negative regulation of protein metabolic processGO:00512482820.015
midgut developmentGO:000749440.015
negative regulation of proteolysisGO:0045861740.015
viral gene expressionGO:001908030.015
negative regulation of organelle organizationGO:0010639900.015
golgi vesicle transportGO:0048193300.015
cytokine productionGO:00018163190.015
Mouse
organic anion transportGO:00157111370.015
positive regulation of nfat protein import into nucleusGO:005153310.015
positive regulation of secretion by cellGO:19035321140.015
connective tissue developmentGO:00614481790.015
actin filament polymerizationGO:0030041440.015
cell cycle g1 s phase transitionGO:0044843570.014
regulation of lymphocyte activationGO:00512492400.014
heart morphogenesisGO:00030071780.014
regulation of exocytosisGO:0017157610.014
vesicle transport along microtubuleGO:004749690.014
segmentationGO:0035282930.014
regulation of mitotic cell cycle phase transitionGO:1901990730.014
vesicle organizationGO:0016050600.014
negative regulation of endopeptidase activityGO:0010951440.014
g1 s transition of mitotic cell cycleGO:0000082570.014
glycerolipid metabolic processGO:00464861220.014
regulation of necrotic cell deathGO:0010939130.014
striated muscle contractionGO:0006941450.014
Mouse
myosin filament assemblyGO:003103420.014
muscle cell proliferationGO:0033002520.014
t cell activationGO:00421102890.014
positive regulation of cell migrationGO:00303351090.014
interspecies interaction between organismsGO:0044419830.014
methylationGO:00322591340.014

Map2k4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
musculoskeletal system diseaseDOID:1700.015
disease of anatomical entityDOID:700.015