IMP: Integrative Multi-species Prediction

Mus musculus

0 known processes

Timm23

translocase of inner mitochondrial membrane 23 homolog (yeast)

(Aliases: MGC46821,Tim23)

Entrez: 53600
Ensembl: ENSMUSG00000013701
UniProtKB: Q9CXU4

Process Predictions
Disease Predictions

Timm23 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
purine ribonucleoside metabolic process	GO:0046128	241	0.404
nucleoside triphosphate metabolic process	GO:0009141	230	0.364
mitochondrion organization	GO:0007005	134	0.351
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.330
atp metabolic process	GO:0046034	75	0.309
ribose phosphate metabolic process	GO:0019693	291	0.299
positive regulation of hydrolase activity	GO:0051345	148	0.286
transmembrane transport	GO:0055085	412	0.286
nucleotide metabolic process	GO:0009117	332	0.276
proteolysis involved in cellular protein catabolic process	GO:0051603	147	0.256
generation of precursor metabolites and energy	GO:0006091	103	0.246
positive regulation of peptidase activity	GO:0010952	49	0.239
nucleobase containing small molecule metabolic process	GO:0055086	352	0.236
nucleoside phosphate metabolic process	GO:0006753	338	0.233
cellular respiration	GO:0045333	38	0.201
macromolecule catabolic process	GO:0009057	281	0.198
mitochondrial transport	GO:0006839	36	0.166
regulation of hydrolase activity	GO:0051336	246	0.164
response to oxidative stress	GO:0006979	123	0.160
positive regulation of apoptotic process	GO:0043065	217	0.152
positive regulation of proteolysis	GO:0045862	85	0.149
purine ribonucleotide metabolic process	GO:0009150	290	0.137
regulation of phosphatidylcholine biosynthetic process	GO:2001245	2	0.132
defecation	GO:0030421	1	0.126
regulation of membrane potential	GO:0042391	192	0.126
purine nucleoside metabolic process	GO:0042278	241	0.124
development of primary sexual characteristics	GO:0045137	143	0.124	Worm
protein processing	GO:0016485	163	0.121
positive regulation of programmed cell death	GO:0043068	218	0.116
nucleoside metabolic process	GO:0009116	246	0.114
negative regulation of intrinsic apoptotic signaling pathway	GO:2001243	34	0.113
protein catabolic process	GO:0030163	221	0.111
regulation of intrinsic apoptotic signaling pathway	GO:2001242	61	0.103
regulation of endopeptidase activity	GO:0052548	89	0.097
protein localization to mitochondrion	GO:0070585	15	0.097
positive regulation of endopeptidase activity	GO:0010950	43	0.094
purine nucleoside monophosphate metabolic process	GO:0009126	81	0.089
cellular homeostasis	GO:0019725	240	0.087
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.082
ribonucleoside metabolic process	GO:0009119	245	0.082
glycosyl compound metabolic process	GO:1901657	246	0.079
intrinsic apoptotic signaling pathway	GO:0097193	132	0.078
ribonucleotide metabolic process	GO:0009259	291	0.076
purine ribonucleoside monophosphate metabolic process	GO:0009167	80	0.076
negative regulation of cell proliferation	GO:0008285	296	0.073
protein maturation	GO:0051604	176	0.071
dna metabolic process	GO:0006259	303	0.070
negative regulation of intracellular signal transduction	GO:1902532	167	0.069
cellular protein catabolic process	GO:0044257	155	0.066
purine nucleotide catabolic process	GO:0006195	211	0.064
spermatogenesis	GO:0007283	284	0.061
energy derivation by oxidation of organic compounds	GO:0015980	77	0.059
zymogen activation	GO:0031638	41	0.059
aromatic compound catabolic process	GO:0019439	286	0.059
positive regulation of cell death	GO:0010942	224	0.059
apoptotic signaling pathway	GO:0097190	306	0.058
nucleotide catabolic process	GO:0009166	217	0.058
cytoplasmic transport	GO:0016482	234	0.057
oxidation reduction process	GO:0055114	342	0.054
regulation of proteolysis	GO:0030162	164	0.053
purine containing compound metabolic process	GO:0072521	311	0.053
purine nucleotide metabolic process	GO:0006163	302	0.048
ubiquitin dependent protein catabolic process	GO:0006511	129	0.048
membrane organization	GO:0061024	245	0.047
regulation of nucleoside metabolic process	GO:0009118	130	0.047
metal ion homeostasis	GO:0055065	189	0.047
organophosphate biosynthetic process	GO:0090407	122	0.046
modification dependent protein catabolic process	GO:0019941	133	0.046
locomotory behavior	GO:0007626	195	0.045
male gamete generation	GO:0048232	285	0.045
gland development	GO:0048732	330	0.044
response to superoxide	GO:0000303	16	0.043
proteasomal protein catabolic process	GO:0010498	98	0.042
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.042
reactive oxygen species metabolic process	GO:0072593	84	0.042
organic acid biosynthetic process	GO:0016053	86	0.042
cellular macromolecule catabolic process	GO:0044265	206	0.040
carbohydrate derivative biosynthetic process	GO:1901137	183	0.040
multicellular organismal aging	GO:0010259	24	0.040
proteasomal ubiquitin independent protein catabolic process	GO:0010499	1	0.039
ion transmembrane transport	GO:0034220	361	0.039
glycerolipid metabolic process	GO:0046486	122	0.039
regulation of apoptotic signaling pathway	GO:2001233	197	0.038
glycerophospholipid metabolic process	GO:0006650	71	0.038
regulation of cysteine type endopeptidase activity	GO:2000116	65	0.038
cofactor metabolic process	GO:0051186	80	0.036
protein localization to organelle	GO:0033365	185	0.035
purine ribonucleotide catabolic process	GO:0009154	208	0.035
nucleoside triphosphate catabolic process	GO:0009143	205	0.034
regulation of nucleotide metabolic process	GO:0006140	169	0.034
cellular amino acid metabolic process	GO:0006520	103	0.033
nucleoside monophosphate metabolic process	GO:0009123	85	0.033
amine metabolic process	GO:0009308	45	0.033
regulation of cellular catabolic process	GO:0031329	242	0.033
nucleoside phosphate biosynthetic process	GO:1901293	79	0.033
cation transport	GO:0006812	399	0.032
endocytosis	GO:0006897	168	0.032
protein import	GO:0017038	101	0.032
response to oxygen levels	GO:0070482	62	0.032
apoptotic mitochondrial changes	GO:0008637	48	0.032
regulation of blood pressure	GO:0008217	93	0.030
positive regulation of growth	GO:0045927	104	0.030
cellular lipid metabolic process	GO:0044255	323	0.030
gonad development	GO:0008406	141	0.029	Worm
nitrogen compound transport	GO:0071705	271	0.029
regulation of cellular amine metabolic process	GO:0033238	20	0.029
positive regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043280	36	0.028
regulation of mitochondrial membrane potential	GO:0051881	17	0.028
carbohydrate derivative catabolic process	GO:1901136	231	0.028
cellular amine metabolic process	GO:0044106	44	0.027
protein polymerization	GO:0051258	57	0.027
regulation of protein processing	GO:0070613	96	0.027
purine nucleoside catabolic process	GO:0006152	205	0.027
heterocycle catabolic process	GO:0046700	280	0.026
regulation of organelle organization	GO:0033043	289	0.026
neuron apoptotic process	GO:0051402	142	0.026
divalent inorganic cation homeostasis	GO:0072507	138	0.025
anion transport	GO:0006820	177	0.024
age dependent response to oxidative stress	GO:0001306	3	0.024
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	62	0.024
regulation of protein maturation	GO:1903317	96	0.024
ribonucleotide catabolic process	GO:0009261	208	0.024
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.024
activation of cysteine type endopeptidase activity involved in apoptotic process	GO:0006919	27	0.024
regulation of peptidase activity	GO:0052547	96	0.024
extracellular structure organization	GO:0043062	148	0.024
regulation of nucleotide catabolic process	GO:0030811	122	0.023
response to oxygen radical	GO:0000305	16	0.023
response to hypoxia	GO:0001666	58	0.023
cellular protein complex assembly	GO:0043623	116	0.023
negative regulation of cellular component organization	GO:0051129	194	0.023
cell type specific apoptotic process	GO:0097285	268	0.022
cellular response to dna damage stimulus	GO:0006974	207	0.022
regulation of cellular amino acid metabolic process	GO:0006521	5	0.022
response to organonitrogen compound	GO:0010243	246	0.022
inorganic cation transmembrane transport	GO:0098662	207	0.021
organophosphate catabolic process	GO:0046434	232	0.021
negative regulation of growth	GO:0045926	99	0.021
regulation of cellular ketone metabolic process	GO:0010565	66	0.021
regulation of cell activation	GO:0050865	289	0.021
response to molecule of bacterial origin	GO:0002237	143	0.021
regulation of purine nucleotide metabolic process	GO:1900542	169	0.021
neural tube formation	GO:0001841	108	0.020
regulation of cell motility	GO:2000145	236	0.020
intracellular protein transport	GO:0006886	204	0.020
epithelial cell proliferation	GO:0050673	174	0.020
regulation of defense response	GO:0031347	233	0.020
mitochondrion morphogenesis	GO:0070584	13	0.020
mapk cascade	GO:0000165	281	0.020
organonitrogen compound catabolic process	GO:1901565	264	0.020
purine containing compound catabolic process	GO:0072523	213	0.020
negative regulation of alcohol biosynthetic process	GO:1902931	4	0.020
reactive oxygen species biosynthetic process	GO:1903409	8	0.020
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.019
cytokine production	GO:0001816	319	0.019
divalent inorganic cation transport	GO:0072511	178	0.019
negative regulation of phosphorus metabolic process	GO:0010563	184	0.019
regulation of protein targeting	GO:1903533	61	0.019
immune effector process	GO:0002252	321	0.018
regulation of membrane permeability	GO:0090559	18	0.018
sulfur compound biosynthetic process	GO:0044272	37	0.018
cellular metal ion homeostasis	GO:0006875	151	0.018
age dependent general metabolic decline	GO:0007571	3	0.018
positive regulation of cellular amine metabolic process	GO:0033240	5	0.018
phagocytosis	GO:0006909	66	0.018
regulation of phospholipid biosynthetic process	GO:0071071	3	0.018
cellular ion homeostasis	GO:0006873	165	0.018
regulation of cellular component biogenesis	GO:0044087	181	0.018
oxidative phosphorylation	GO:0006119	14	0.017
t cell activation	GO:0042110	289	0.017
organic cyclic compound catabolic process	GO:1901361	295	0.017
phosphatidylethanolamine metabolic process	GO:0046337	2	0.017
small gtpase mediated signal transduction	GO:0007264	97	0.017
cellular nitrogen compound catabolic process	GO:0044270	280	0.017
dephosphorylation	GO:0016311	129	0.017
ribonucleoside monophosphate metabolic process	GO:0009161	80	0.017
nucleoside catabolic process	GO:0009164	206	0.017
activation of cysteine type endopeptidase activity	GO:0097202	27	0.016
negative regulation of mitochondrion organization	GO:0010823	9	0.016
regulation of lymphocyte activation	GO:0051249	240	0.016
calcium ion homeostasis	GO:0055074	127	0.016
regulation of leukocyte differentiation	GO:1902105	159	0.016
response to inorganic substance	GO:0010035	96	0.016
cation homeostasis	GO:0055080	212	0.016
positive regulation of purine nucleotide metabolic process	GO:1900544	114	0.015
peptidyl amino acid modification	GO:0018193	336	0.015
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	88	0.015
regulation of cell growth	GO:0001558	91	0.015
nucleoside monophosphate catabolic process	GO:0009125	59	0.015
leukocyte mediated immunity	GO:0002443	174	0.015
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.015
activation of immune response	GO:0002253	138	0.015
blastocyst development	GO:0001824	80	0.015
coenzyme biosynthetic process	GO:0009108	23	0.015
cellular chemical homeostasis	GO:0055082	215	0.015
cellular divalent inorganic cation homeostasis	GO:0072503	127	0.015
regulation of lipid metabolic process	GO:0019216	118	0.015
heart morphogenesis	GO:0003007	178	0.014
regulation of feeding behavior	GO:0060259	3	0.014
positive regulation of nucleoside metabolic process	GO:0045979	91	0.014
wound healing	GO:0042060	157	0.014
positive regulation of protein modification process	GO:0031401	299	0.014
regulation of body fluid levels	GO:0050878	162	0.014
cellular response to cytokine stimulus	GO:0071345	189	0.014
regulation of mitochondrion organization	GO:0010821	27	0.014
sulfur compound metabolic process	GO:0006790	100	0.014
protein ubiquitination	GO:0016567	171	0.014
regulation of protein complex assembly	GO:0043254	83	0.014
small molecule biosynthetic process	GO:0044283	132	0.014
immune response regulating signaling pathway	GO:0002764	125	0.014
negative regulation of cellular amine metabolic process	GO:0033239	1	0.014
cellular response to organonitrogen compound	GO:0071417	145	0.014
regulation of intracellular transport	GO:0032386	159	0.013
neuron death	GO:0070997	154	0.013
g protein coupled receptor signaling pathway	GO:0007186	243	0.013
response to reactive oxygen species	GO:0000302	56	0.013
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.013
regulation of reactive oxygen species metabolic process	GO:2000377	40	0.013
protein modification by small protein conjugation or removal	GO:0070647	207	0.013
regulation of alpha amino 3 hydroxy 5 methyl 4 isoxazole propionate selective glutamate receptor activity	GO:2000311	11	0.013
protein targeting	GO:0006605	143	0.013
regulation of t cell activation	GO:0050863	170	0.013
positive regulation of reactive oxygen species metabolic process	GO:2000379	11	0.013
cellular ketone metabolic process	GO:0042180	84	0.013
neural precursor cell proliferation	GO:0061351	121	0.013
regulation of cytoskeleton organization	GO:0051493	122	0.013
synaptic transmission	GO:0007268	329	0.013
epithelial tube morphogenesis	GO:0060562	303	0.013
cellular response to oxidative stress	GO:0034599	76	0.012
multicellular organism growth	GO:0035264	161	0.012
positive regulation of apoptotic signaling pathway	GO:2001235	95	0.012
modification dependent macromolecule catabolic process	GO:0043632	133	0.012
reactive nitrogen species metabolic process	GO:2001057	0	0.012
insulin secretion	GO:0030073	89	0.012
positive regulation of protein phosphorylation	GO:0001934	242	0.012
protein methylation	GO:0006479	81	0.012
positive regulation of organelle organization	GO:0010638	128	0.012
sensory perception	GO:0007600	245	0.012
regulation of reactive oxygen species biosynthetic process	GO:1903426	2	0.012
regulation of cytokine production	GO:0001817	266	0.012
purine nucleotide biosynthetic process	GO:0006164	65	0.012
engulfment of apoptotic cell	GO:0043652	3	0.012
divalent metal ion transport	GO:0070838	172	0.012
inflammatory response	GO:0006954	244	0.012
monocarboxylic acid biosynthetic process	GO:0072330	61	0.012
phosphatidylglycerol metabolic process	GO:0046471	3	0.012
cation transmembrane transport	GO:0098655	266	0.012
immune response activating signal transduction	GO:0002757	116	0.012
innate immune response	GO:0045087	157	0.012
regulation of anatomical structure size	GO:0090066	178	0.012
phospholipid metabolic process	GO:0006644	87	0.011
establishment of protein localization to organelle	GO:0072594	118	0.011
organic hydroxy compound metabolic process	GO:1901615	203	0.011
germ cell development	GO:0007281	185	0.011
regulation of establishment of protein localization	GO:0070201	181	0.011
response to decreased oxygen levels	GO:0036293	59	0.011
ribonucleoside catabolic process	GO:0042454	206	0.011
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.011
protein kinase b signaling	GO:0043491	74	0.011
regulation of hormone levels	GO:0010817	211	0.011
carboxylic acid biosynthetic process	GO:0046394	86	0.011
cytokine mediated signaling pathway	GO:0019221	115	0.011
oogenesis	GO:0048477	56	0.011
positive regulation of protein kinase activity	GO:0045860	144	0.011
tube formation	GO:0035148	140	0.010
negative regulation of phospholipid biosynthetic process	GO:0071072	1	0.010
inorganic ion transmembrane transport	GO:0098660	234	0.010
positive regulation of cysteine type endopeptidase activity	GO:2001056	39	0.010
lymphocyte proliferation	GO:0046651	164	0.010
posttranscriptional regulation of gene expression	GO:0010608	155	0.010
receptor mediated endocytosis	GO:0006898	51	0.010
positive regulation of reactive oxygen species biosynthetic process	GO:1903428	2	0.010
leukocyte proliferation	GO:0070661	172	0.010
hydrogen peroxide metabolic process	GO:0042743	16	0.010
leukocyte migration	GO:0050900	124	0.010
regulation of epithelial cell proliferation	GO:0050678	141	0.010

Timm23 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
disease of metabolism	DOID:0014667	0.031
hematopoietic system disease	DOID:74	0.023
blood coagulation disease	DOID:1247	0.023
disease of anatomical entity	DOID:7	0.023
immune system disease	DOID:2914	0.023
inherited metabolic disorder	DOID:655	0.018
nervous system disease	DOID:863	0.018
central nervous system disease	DOID:331	0.015

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