IMP: Integrative Multi-species Prediction

Mus musculus

0 known processes

Nkx2-4

NK2 transcription factor related, locus 4 (Drosophila)

(Aliases: tinman,Nkx-2.4,1700001P03Rik)

Ensembl: ENSMUSG00000054160
Entrez: 228731
UniProtKB: Q9EQM3

Process Predictions
Disease Predictions

Nkx2-4 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
cell fate commitment	GO:0045165	210	0.707	Mouse
regulation of neuron differentiation	GO:0045664	281	0.645	Mouse
regionalization	GO:0003002	337	0.562	Mouse
heart morphogenesis	GO:0003007	178	0.518	Mouse
telencephalon development	GO:0021537	186	0.479	Mouse
skeletal system development	GO:0001501	356	0.431	Mouse
connective tissue development	GO:0061448	179	0.404	Mouse
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.390	Mouse
determination of left right symmetry	GO:0007368	80	0.388	Mouse
striated muscle tissue development	GO:0014706	293	0.370	Mouse
muscle tissue development	GO:0060537	308	0.359	Mouse
renal system development	GO:0072001	225	0.355
neuron fate specification	GO:0048665	30	0.353	Mouse
camera type eye development	GO:0043010	266	0.334
embryonic organ morphogenesis	GO:0048562	276	0.323	Mouse
mesoderm morphogenesis	GO:0048332	64	0.307
epithelial cell development	GO:0002064	159	0.299	Mouse
bmp signaling pathway	GO:0030509	93	0.290	Mouse
cell fate specification	GO:0001708	72	0.276	Mouse
mesoderm development	GO:0007498	100	0.273
pancreatic pp cell differentiation	GO:0003312	2	0.273	Mouse
cartilage development	GO:0051216	140	0.270	Mouse
mesoderm formation	GO:0001707	62	0.267
stem cell differentiation	GO:0048863	268	0.261	Mouse
digestive system development	GO:0055123	200	0.259	Mouse
digestive tract development	GO:0048565	190	0.251	Mouse
outflow tract morphogenesis	GO:0003151	53	0.248	Mouse
regulation of organ morphogenesis	GO:2000027	144	0.242
paraxial mesodermal cell differentiation	GO:0048342	2	0.242
forebrain development	GO:0030900	302	0.241	Mouse
digestive tract morphogenesis	GO:0048546	147	0.240	Mouse
embryonic heart tube development	GO:0035050	65	0.231	Mouse
stem cell proliferation	GO:0072089	117	0.221
negative regulation of cell proliferation	GO:0008285	296	0.218	Mouse
kidney development	GO:0001822	213	0.217
regulation of kinase activity	GO:0043549	249	0.207
cardiac ventricle development	GO:0003231	83	0.200	Mouse
endocrine system development	GO:0035270	98	0.198	Zebrafish Mouse
cardiac muscle tissue development	GO:0048738	130	0.195	Mouse
sensory organ morphogenesis	GO:0090596	242	0.189	Mouse
cardiac chamber morphogenesis	GO:0003206	93	0.189	Mouse
pallium development	GO:0021543	120	0.188	Mouse
skeletal system morphogenesis	GO:0048705	203	0.188	Mouse
myeloid leukocyte differentiation	GO:0002573	119	0.182	Mouse
morphogenesis of embryonic epithelium	GO:0016331	159	0.180
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	112	0.180
formation of primary germ layer	GO:0001704	77	0.177
embryonic heart tube morphogenesis	GO:0003143	51	0.177	Mouse
negative regulation of neuron differentiation	GO:0045665	101	0.173	Mouse
positive regulation of voltage gated calcium channel activity	GO:1901387	2	0.172	Mouse
ear development	GO:0043583	200	0.171	Mouse
negative regulation of nervous system development	GO:0051961	156	0.171	Mouse
limbic system development	GO:0021761	72	0.165	Mouse
striated muscle cell proliferation	GO:0014855	39	0.160	Mouse
appendage morphogenesis	GO:0035107	149	0.159
globus pallidus development	GO:0021759	2	0.158	Mouse
spleen development	GO:0048536	39	0.156	Mouse
cell type specific apoptotic process	GO:0097285	268	0.153	Mouse
lateral inhibition	GO:0046331	1	0.152
cell recognition	GO:0008037	83	0.149
axonogenesis	GO:0007409	274	0.148	Mouse
leukocyte differentiation	GO:0002521	342	0.146	Mouse
inorganic cation transmembrane transport	GO:0098662	207	0.141	Mouse
epidermis development	GO:0008544	187	0.140
astrocyte fate commitment	GO:0060018	4	0.138
epithelial tube morphogenesis	GO:0060562	303	0.138	Mouse
embryonic skeletal system development	GO:0048706	120	0.137	Mouse
ossification	GO:0001503	216	0.134
microtubule based process	GO:0007017	236	0.133
muscle tissue morphogenesis	GO:0060415	53	0.132	Mouse
positive regulation of protein modification process	GO:0031401	299	0.129
pancreatic a cell fate commitment	GO:0003326	2	0.129	Mouse
ion transmembrane transport	GO:0034220	361	0.129	Mouse
positive regulation of neuron differentiation	GO:0045666	141	0.128	Mouse
respiratory system development	GO:0060541	190	0.128	Mouse
mesenchyme development	GO:0060485	152	0.127	Mouse
blood vessel morphogenesis	GO:0048514	285	0.125	Mouse
thyroid stimulating hormone secreting cell differentiation	GO:0060129	4	0.125
cardiac ventricle morphogenesis	GO:0003208	50	0.125	Mouse
tissue remodeling	GO:0048771	102	0.124
cardiocyte differentiation	GO:0035051	87	0.123	Mouse
smoothened signaling pathway	GO:0007224	105	0.122	Mouse
angiogenesis	GO:0001525	201	0.119
negative regulation of cell development	GO:0010721	169	0.119	Mouse
skeletal muscle cell differentiation	GO:0035914	66	0.118
gland development	GO:0048732	330	0.116	Zebrafish Mouse
regulation of organ formation	GO:0003156	34	0.116
metanephros development	GO:0001656	79	0.116
ventral spinal cord interneuron fate commitment	GO:0060579	14	0.115	Mouse
regulation of transferase activity	GO:0051338	263	0.114
ear morphogenesis	GO:0042471	118	0.113	Mouse
cell adhesion	GO:0007155	329	0.111
pulmonary myocardium development	GO:0003350	3	0.111	Mouse
left right pattern formation	GO:0060972	23	0.110	Mouse
response to growth factor	GO:0070848	198	0.109
spinal cord oligodendrocyte cell differentiation	GO:0021529	3	0.109	Mouse
spinal cord oligodendrocyte cell fate specification	GO:0021530	3	0.108	Mouse
cation transport	GO:0006812	399	0.107	Mouse
respiratory tube development	GO:0030323	167	0.106	Mouse
positive regulation of transferase activity	GO:0051347	167	0.104
stem cell development	GO:0048864	219	0.103
specification of organ identity	GO:0010092	30	0.102
cation transmembrane transport	GO:0098655	266	0.101	Mouse
positive regulation of kinase activity	GO:0033674	155	0.101
cellular amino acid metabolic process	GO:0006520	103	0.100
neural tube development	GO:0021915	160	0.099
primary neural tube formation	GO:0014020	95	0.099
carbon catabolite repression of transcription from rna polymerase ii promoter	GO:0000437	1	0.098
regulation of bmp signaling pathway	GO:0030510	60	0.098
regulation of neuron projection development	GO:0010975	169	0.096
morphogenesis of a branching structure	GO:0001763	203	0.096
positive regulation of transcription via serum response element binding	GO:0010735	1	0.096	Mouse
mesenchymal cell development	GO:0014031	93	0.095
cardiac muscle tissue morphogenesis	GO:0055008	44	0.094	Mouse
male sex differentiation	GO:0046661	109	0.094	Mouse
limb development	GO:0060173	166	0.092
microtubule cytoskeleton organization	GO:0000226	157	0.091
regulation of cell morphogenesis involved in differentiation	GO:0010769	151	0.091
sensory perception	GO:0007600	245	0.091
positive regulation of cell cycle	GO:0045787	92	0.090
developmental maturation	GO:0021700	193	0.090
branching morphogenesis of an epithelial tube	GO:0048754	159	0.089
regulation of cell adhesion	GO:0030155	154	0.089
regulation of testosterone biosynthetic process	GO:2000224	2	0.088
notch signaling pathway	GO:0007219	71	0.086
cardiac pacemaker cell fate commitment	GO:0060927	1	0.086	Mouse
regulation of cell projection organization	GO:0031344	206	0.085
cerebral cortex development	GO:0021987	86	0.085	Mouse
carbohydrate metabolic process	GO:0005975	230	0.084
regulation of ion transmembrane transport	GO:0034765	119	0.083	Mouse
organ growth	GO:0035265	117	0.083	Mouse
pancreatic pp cell fate commitment	GO:0003329	2	0.083	Mouse
pancreas development	GO:0031016	57	0.082	Mouse
determination of heart left right asymmetry	GO:0061371	48	0.081	Mouse
regulation of cell motility	GO:2000145	236	0.081
paraxial mesodermal cell fate commitment	GO:0048343	2	0.081
regulation of microtubule based process	GO:0032886	52	0.080
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090100	43	0.080
hormone metabolic process	GO:0042445	86	0.080
embryonic epithelial tube formation	GO:0001838	130	0.080
regulation of protein kinase activity	GO:0045859	232	0.080
hippocampus development	GO:0021766	52	0.079	Mouse
response to transforming growth factor beta	GO:0071559	88	0.079
inner ear morphogenesis	GO:0042472	101	0.079
cardiac chamber development	GO:0003205	108	0.078	Mouse
neural precursor cell proliferation	GO:0061351	121	0.076
atrioventricular node cell development	GO:0060928	2	0.075	Mouse
septum transversum development	GO:0003343	2	0.072	Mouse
action potential	GO:0001508	78	0.072
mesenchymal cell differentiation	GO:0048762	107	0.072
positive regulation of mapk cascade	GO:0043410	170	0.072
negative regulation of cellular component organization	GO:0051129	194	0.072
epithelial tube formation	GO:0072175	130	0.071
regulation of cell activation	GO:0050865	289	0.071
phagocytosis	GO:0006909	66	0.071
neuron migration	GO:0001764	122	0.070	Mouse
regulation of muscle tissue development	GO:1901861	97	0.070	Mouse
his purkinje system cell differentiation	GO:0060932	2	0.070	Mouse
regulation of cell migration	GO:0030334	219	0.068
artery development	GO:0060840	53	0.068
spermatogenesis	GO:0007283	284	0.067
appendage development	GO:0048736	166	0.067
odontogenesis of dentin containing tooth	GO:0042475	66	0.067	Mouse
regulation of stem cell proliferation	GO:0072091	78	0.067
regulation of cell cycle process	GO:0010564	160	0.067
regulation of cardiac muscle tissue growth	GO:0055021	26	0.067	Mouse
regulation of cellular amino acid metabolic process	GO:0006521	5	0.066
ureteric bud development	GO:0001657	94	0.066
negative regulation of molecular function	GO:0044092	258	0.065
regulation of organelle organization	GO:0033043	289	0.065
ventricular cardiac muscle tissue morphogenesis	GO:0055010	32	0.065	Mouse
negative regulation of wnt signaling pathway	GO:0030178	73	0.064	Mouse
positive regulation of nervous system development	GO:0051962	221	0.063	Mouse
negative regulation of phosphate metabolic process	GO:0045936	184	0.063
skin development	GO:0043588	220	0.063
regulation of ossification	GO:0030278	112	0.063
regulation of epithelial cell proliferation	GO:0050678	141	0.063	Mouse
regulation of reproductive process	GO:2000241	66	0.062
mitotic cell cycle	GO:0000278	195	0.062
cell fate determination	GO:0001709	32	0.062	Mouse
regulation of transmembrane transport	GO:0034762	128	0.062	Mouse
negative regulation of neuron projection development	GO:0010977	50	0.061
neural crest cell differentiation	GO:0014033	54	0.061
forebrain neuron differentiation	GO:0021879	52	0.061	Mouse
visceral serous pericardium development	GO:0061032	2	0.061
regulation of hormone levels	GO:0010817	211	0.061
ventral spinal cord interneuron fate determination	GO:0060580	1	0.060	Mouse
segmentation	GO:0035282	93	0.060
chromatin organization	GO:0006325	206	0.060
regulation of voltage gated calcium channel activity	GO:1901385	4	0.060	Mouse
renal tubule morphogenesis	GO:0061333	72	0.060
b cell activation	GO:0042113	161	0.059	Mouse
skeletal muscle organ development	GO:0060538	163	0.059
proteoglycan metabolic process	GO:0006029	38	0.059
negative regulation of organelle organization	GO:0010639	90	0.059
heart growth	GO:0060419	45	0.059	Mouse
regulation of cell cycle	GO:0051726	281	0.058
hair follicle development	GO:0001942	85	0.057
positive regulation of cell development	GO:0010720	237	0.057	Mouse
spinal cord motor neuron differentiation	GO:0021522	35	0.057	Mouse
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.057
cellular response to growth factor stimulus	GO:0071363	197	0.057
secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development	GO:0060528	4	0.057
tissue migration	GO:0090130	68	0.056
t cell activation	GO:0042110	289	0.056	Mouse
intracellular protein transport	GO:0006886	204	0.056
single organism cell adhesion	GO:0098602	156	0.056
cellular ketone metabolic process	GO:0042180	84	0.056
placenta development	GO:0001890	140	0.056
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.055
cellular amine metabolic process	GO:0044106	44	0.055
synaptic transmission	GO:0007268	329	0.055
epithelial cell migration	GO:0010631	63	0.055
columnar cuboidal epithelial cell differentiation	GO:0002065	82	0.055	Mouse
calcium ion transmembrane transport	GO:0070588	85	0.055	Mouse
atrial cardiac muscle cell development	GO:0055014	2	0.054	Mouse
t cell differentiation	GO:0030217	174	0.054	Mouse
endothelial cell differentiation	GO:0045446	41	0.054
mechanoreceptor differentiation	GO:0042490	67	0.053
keratinocyte proliferation	GO:0043616	21	0.053
divalent metal ion transport	GO:0070838	172	0.053	Mouse
menarche	GO:0042696	1	0.053	Mouse
synapse organization	GO:0050808	125	0.053
embryonic placenta development	GO:0001892	98	0.052
cell differentiation in spinal cord	GO:0021515	53	0.052	Mouse
locomotory behavior	GO:0007626	195	0.052	Mouse
gastrulation	GO:0007369	116	0.051
central nervous system vasculogenesis	GO:0022009	3	0.051
negative regulation of intracellular signal transduction	GO:1902532	167	0.051
positive regulation of cell adhesion	GO:0045785	80	0.051
mesenchyme morphogenesis	GO:0072132	32	0.050
forebrain regionalization	GO:0021871	25	0.050	Mouse
lymphocyte differentiation	GO:0030098	242	0.050	Mouse
homeostasis of number of cells	GO:0048872	210	0.050	Mouse
male gamete generation	GO:0048232	285	0.049
neural crest cell development	GO:0014032	48	0.049
regulation of sequence specific dna binding transcription factor activity	GO:0051090	106	0.049	Mouse
regulation of organ growth	GO:0046620	61	0.049	Mouse
mesonephric epithelium development	GO:0072163	94	0.049
purkinje myocyte differentiation	GO:0003168	1	0.049	Mouse
inorganic ion transmembrane transport	GO:0098660	234	0.048	Mouse
negative regulation of cell cycle	GO:0045786	123	0.048
proepicardium development	GO:0003342	2	0.048	Mouse
atrioventricular node cell fate commitment	GO:0060929	1	0.048	Mouse
renal outer medulla development	GO:0072054	2	0.048
tube closure	GO:0060606	91	0.047
somatotropin secreting cell differentiation	GO:0060126	4	0.047
dna metabolic process	GO:0006259	303	0.046
regulation of neural precursor cell proliferation	GO:2000177	70	0.046
urogenital system development	GO:0001655	261	0.046
wnt signaling pathway	GO:0016055	188	0.046	Mouse
auditory receptor cell fate specification	GO:0042667	1	0.045
regulation of wnt signaling pathway	GO:0030111	123	0.045	Mouse
fat cell differentiation	GO:0045444	160	0.045
forebrain cell migration	GO:0021885	58	0.045	Mouse
spinal cord development	GO:0021510	81	0.044	Mouse
plasma cell differentiation	GO:0002317	3	0.044	Mouse
endocardial cushion development	GO:0003197	26	0.044
g protein coupled receptor signaling pathway	GO:0007186	243	0.044
cardiac muscle tissue growth	GO:0055017	37	0.044	Mouse
limb morphogenesis	GO:0035108	149	0.044
epithelium migration	GO:0090132	63	0.044
diencephalon development	GO:0021536	63	0.043	Mouse
glandular epithelial cell differentiation	GO:0002067	38	0.043	Mouse
cell maturation	GO:0048469	127	0.043
mitotic cell cycle process	GO:1903047	159	0.043
cardiac neural crest cell migration involved in outflow tract morphogenesis	GO:0003253	3	0.042
carbon catabolite activation of transcription	GO:0045991	4	0.042
neural tube closure	GO:0001843	90	0.042
chromatin modification	GO:0016568	187	0.042
extracellular structure organization	GO:0043062	148	0.041
ameboidal type cell migration	GO:0001667	128	0.041
response to radiation	GO:0009314	165	0.041
negative regulation of cell projection organization	GO:0031345	56	0.041
positive regulation of cellular amine metabolic process	GO:0033240	5	0.041
carbon catabolite activation of transcription from rna polymerase ii promoter	GO:0000436	4	0.041
atrioventricular node cell differentiation	GO:0060922	2	0.041	Mouse
mesodermal cell differentiation	GO:0048333	22	0.041
aminoglycan metabolic process	GO:0006022	34	0.041
post anal tail morphogenesis	GO:0036342	23	0.040
nephron tubule morphogenesis	GO:0072078	68	0.040
lung development	GO:0030324	164	0.040	Mouse
dendrite development	GO:0016358	115	0.040	Fly
regulation of retina development in camera type eye	GO:1902866	3	0.040
neuromuscular process	GO:0050905	99	0.040
positive regulation of rna polymerase ii transcriptional preinitiation complex assembly	GO:0045899	2	0.040
central nervous system neuron differentiation	GO:0021953	162	0.040	Mouse
neuroepithelial cell differentiation	GO:0060563	37	0.040
endocytosis	GO:0006897	168	0.040
cell fate commitment involved in formation of primary germ layer	GO:0060795	26	0.039
regulation of osteoblast differentiation	GO:0045667	67	0.039
cytoplasmic transport	GO:0016482	234	0.039
nucleoside phosphate metabolic process	GO:0006753	338	0.039
myeloid cell differentiation	GO:0030099	233	0.039	Mouse
regulation of neural retina development	GO:0061074	3	0.039
blood circulation	GO:0008015	195	0.039	Mouse
mesonephric tubule development	GO:0072164	94	0.038
axis elongation involved in somitogenesis	GO:0090245	4	0.038
heart formation	GO:0060914	16	0.038
endocrine pancreas development	GO:0031018	29	0.038	Mouse
tissue homeostasis	GO:0001894	115	0.038
kidney morphogenesis	GO:0060993	83	0.038
uterus morphogenesis	GO:0061038	2	0.038
oviduct development	GO:0060066	3	0.038
forebrain generation of neurons	GO:0021872	63	0.038	Mouse
regulation of anagen	GO:0051884	1	0.038
regulation of cellular component size	GO:0032535	121	0.038
regulation of heart growth	GO:0060420	31	0.038	Mouse
palate development	GO:0060021	76	0.037
regulation of auditory receptor cell differentiation	GO:0045607	4	0.037
sclerotome development	GO:0061056	4	0.037
regulation of cellular response to growth factor stimulus	GO:0090287	82	0.037
hair cycle	GO:0042633	90	0.037
inner medullary collecting duct development	GO:0072061	2	0.037
mesodermal cell fate commitment	GO:0001710	17	0.037
hindbrain development	GO:0030902	128	0.037
cardiac muscle cell proliferation	GO:0060038	31	0.036	Mouse
muscle cell differentiation	GO:0042692	261	0.036	Mouse
tube formation	GO:0035148	140	0.036
positive regulation of bmp signaling pathway	GO:0030513	23	0.036
germ cell development	GO:0007281	185	0.036
regulation of endocardial cushion to mesenchymal transition involved in heart valve formation	GO:2000800	1	0.036
positive regulation of epithelial cell proliferation	GO:0050679	68	0.036
axon guidance	GO:0007411	141	0.036	Mouse
regulation of myeloid cell differentiation	GO:0045637	96	0.036
fertilization	GO:0009566	127	0.036
regulation of mitotic cell cycle	GO:0007346	126	0.036
organic hydroxy compound metabolic process	GO:1901615	203	0.036
paramesonephric duct development	GO:0061205	3	0.035
endothelium development	GO:0003158	45	0.035
regulation of membrane potential	GO:0042391	192	0.035
neural tube formation	GO:0001841	108	0.035
canonical wnt signaling pathway	GO:0060070	130	0.035	Mouse
semicircular canal fusion	GO:0060879	1	0.035
midbrain hindbrain boundary maturation	GO:0021732	1	0.035
somitogenesis	GO:0001756	69	0.035
protein polymerization	GO:0051258	57	0.035
nucleocytoplasmic transport	GO:0006913	139	0.034
protein depolymerization	GO:0051261	34	0.034
nephron development	GO:0072006	109	0.034
regulation of lymphocyte activation	GO:0051249	240	0.034
regulation of embryonic development	GO:0045995	71	0.034
glial cell development	GO:0021782	54	0.034	Mouse
positive regulation of protein kinase activity	GO:0045860	144	0.034
neuronal action potential	GO:0019228	54	0.034
bone morphogenesis	GO:0060349	78	0.034
embryonic appendage morphogenesis	GO:0035113	126	0.033
endodermal cell fate specification	GO:0001714	4	0.033
pyramidal neuron migration	GO:0021852	1	0.033
positive regulation of anagen	GO:0051885	1	0.033
carbon catabolite regulation of transcription	GO:0045990	4	0.033
regulation of canonical wnt signaling pathway involved in controlling type b pancreatic cell proliferation	GO:2000079	1	0.033
ectoderm formation	GO:0001705	3	0.033
b cell differentiation	GO:0030183	78	0.032	Mouse
ventricular cardiac muscle tissue development	GO:0003229	38	0.032	Mouse
nuclear transport	GO:0051169	139	0.032
developmental growth involved in morphogenesis	GO:0060560	138	0.032
neural tube patterning	GO:0021532	43	0.032
organelle fission	GO:0048285	170	0.032
cell matrix adhesion	GO:0007160	68	0.032
protein modification by small protein conjugation or removal	GO:0070647	207	0.032
positive regulation of epithelial cell proliferation involved in lung morphogenesis	GO:0060501	3	0.032
transmembrane transport	GO:0055085	412	0.032	Mouse
cellular protein complex assembly	GO:0043623	116	0.032
positive regulation of cardioblast differentiation	GO:0051891	3	0.032	Mouse
thymus development	GO:0048538	41	0.031
hexose metabolic process	GO:0019318	98	0.031
positive regulation of fat cell proliferation	GO:0070346	1	0.031
cardiac epithelial to mesenchymal transition	GO:0060317	18	0.031
regulation of cellular amine metabolic process	GO:0033238	20	0.031
mammary gland duct morphogenesis	GO:0060603	38	0.031
auditory receptor cell fate determination	GO:0042668	3	0.031
positive regulation of sequence specific dna binding transcription factor activity	GO:0051091	68	0.031	Mouse
nuclear import	GO:0051170	95	0.031
central nervous system morphogenesis	GO:0021551	2	0.031
negative regulation of apoptotic process involved in outflow tract morphogenesis	GO:1902257	2	0.031
membrane organization	GO:0061024	245	0.031
blood vessel remodeling	GO:0001974	33	0.031
positive regulation of auditory receptor cell differentiation	GO:0045609	1	0.031
nephrogenic mesenchyme development	GO:0072076	3	0.031
mesangial cell differentiation	GO:0072007	4	0.031
cell fate determination involved in pattern specification	GO:0060582	1	0.031	Mouse
cerebellum formation	GO:0021588	1	0.030
positive regulation of transcription by glucose	GO:0046016	3	0.030
regulation of leukocyte differentiation	GO:1902105	159	0.030
multi multicellular organism process	GO:0044706	109	0.030
single organismal cell cell adhesion	GO:0016337	131	0.030
cardiac septum development	GO:0003279	59	0.030
mapk cascade	GO:0000165	281	0.030
muscle cell proliferation	GO:0033002	52	0.030	Mouse
trabecula morphogenesis	GO:0061383	40	0.030	Mouse
mesonephros development	GO:0001823	97	0.030
stem cell maintenance	GO:0019827	130	0.030
morphogenesis of an epithelial fold	GO:0060571	28	0.030
negative regulation of gastrulation	GO:2000542	3	0.030
somatic stem cell maintenance	GO:0035019	47	0.030
development of primary sexual characteristics	GO:0045137	143	0.030	Mouse
regulation of cardiac muscle cell proliferation	GO:0060043	23	0.030	Mouse
protein import	GO:0017038	101	0.030
small gtpase mediated signal transduction	GO:0007264	97	0.030
asymmetric neuroblast division	GO:0055059	1	0.030
mesodermal cell fate specification	GO:0007501	11	0.029
biological phase	GO:0044848	20	0.029	Mouse
negative regulation of kinase activity	GO:0033673	81	0.029
spemann organizer formation at the anterior end of the primitive streak	GO:0060064	1	0.029
regulation of ketone biosynthetic process	GO:0010566	2	0.029
cardiac cell fate determination	GO:0060913	2	0.029
kidney epithelium development	GO:0072073	121	0.029
actin cytoskeleton organization	GO:0030036	220	0.029	Mouse
oligodendrocyte development	GO:0014003	20	0.029	Mouse
forebrain neuron development	GO:0021884	30	0.029
cellular lipid metabolic process	GO:0044255	323	0.029	Mouse
sensory perception of sound	GO:0007605	97	0.029
apoptotic process involved in morphogenesis	GO:0060561	25	0.029	Mouse
cervix development	GO:0060067	2	0.029
spinal cord dorsal ventral patterning	GO:0021513	23	0.029	Mouse
rho protein signal transduction	GO:0007266	32	0.029
zygotic determination of anterior posterior axis embryo	GO:0007354	3	0.028
positive regulation of transcription from rna polymerase ii promoter by glucose	GO:0000432	3	0.028
lung pattern specification process	GO:0060432	1	0.028
closure of optic fissure	GO:0061386	2	0.028
regulation of cell division	GO:0051302	76	0.028
regulation of apoptotic signaling pathway	GO:2001233	197	0.028
glucose metabolic process	GO:0006006	92	0.028
nephron morphogenesis	GO:0072028	69	0.028
regulation of ion transmembrane transporter activity	GO:0032412	54	0.028	Mouse
amine metabolic process	GO:0009308	45	0.027
monosaccharide metabolic process	GO:0005996	106	0.027
positive regulation of high voltage gated calcium channel activity	GO:1901843	1	0.027
muscle contraction	GO:0006936	101	0.027	Mouse
ensheathment of neurons	GO:0007272	76	0.027
response to parathyroid hormone	GO:0071107	3	0.027
protein processing	GO:0016485	163	0.027
organelle localization	GO:0051640	179	0.027
regulation of mapk cascade	GO:0043408	248	0.027
salivary gland development	GO:0007431	37	0.027
regulation of anatomical structure size	GO:0090066	178	0.027
regulation of morphogenesis of a branching structure	GO:0060688	53	0.027
type b pancreatic cell fate commitment	GO:0003327	1	0.027	Mouse
embryonic camera type eye development	GO:0031076	36	0.027
transcription from rna polymerase iii promoter	GO:0006383	3	0.027
metanephric loop of henle development	GO:0072236	4	0.027
renal capsule specification	GO:0072130	1	0.027
cell substrate adhesion	GO:0031589	130	0.027
pattern specification involved in metanephros development	GO:0072268	4	0.027
learning or memory	GO:0007611	148	0.027
hair cell differentiation	GO:0035315	40	0.026
corticotropin hormone secreting cell differentiation	GO:0060128	3	0.026
somite development	GO:0061053	81	0.026
adult behavior	GO:0030534	135	0.026
positive regulation of secretion by cell	GO:1903532	114	0.026
cellular carbohydrate metabolic process	GO:0044262	119	0.026
mammary gland bud formation	GO:0060615	2	0.026
development of primary male sexual characteristics	GO:0046546	88	0.026	Mouse
establishment of organ orientation	GO:0048561	1	0.026
developmental induction	GO:0031128	34	0.026	Mouse
negative regulation of phosphorus metabolic process	GO:0010563	184	0.026
positive regulation of peptide secretion	GO:0002793	33	0.026
calcium ion transport	GO:0006816	159	0.026	Mouse
gonad development	GO:0008406	141	0.026	Mouse
hypophysis morphogenesis	GO:0048850	3	0.026
pericardium development	GO:0060039	16	0.026	Mouse
nucleotide metabolic process	GO:0009117	332	0.026
negative regulation of growth	GO:0045926	99	0.026
cellular response to lipid	GO:0071396	145	0.026
submandibular salivary gland formation	GO:0060661	1	0.026
ras protein signal transduction	GO:0007265	77	0.026
regulation of hormone secretion	GO:0046883	88	0.026
circulatory system process	GO:0003013	197	0.026	Mouse
morphogenesis of a branching epithelium	GO:0061138	193	0.026
regulation of apoptotic process involved in outflow tract morphogenesis	GO:1902256	2	0.026
single organism nuclear import	GO:1902593	95	0.026
muscle system process	GO:0003012	141	0.026	Mouse
cell surface receptor signaling pathway involved in heart development	GO:0061311	15	0.025
nucleobase containing small molecule metabolic process	GO:0055086	352	0.025
regulation of map kinase activity	GO:0043405	120	0.025
ventricular cardiac myofibril assembly	GO:0055005	3	0.025	Mouse
epithelial cell proliferation	GO:0050673	174	0.025	Mouse
metanephric nephron development	GO:0072210	34	0.025
endocardial cushion morphogenesis	GO:0003203	18	0.025
autonomic nervous system development	GO:0048483	43	0.025
inner ear receptor cell differentiation	GO:0060113	61	0.025
type b pancreatic cell differentiation	GO:0003309	13	0.025	Mouse
regulation of microtubule polymerization or depolymerization	GO:0031110	20	0.025
multicellular organismal homeostasis	GO:0048871	164	0.025
regulation of cell size	GO:0008361	72	0.025
macromolecule catabolic process	GO:0009057	281	0.025
prostate gland epithelium morphogenesis	GO:0060740	31	0.025
granulocyte colony stimulating factor production	GO:0071611	1	0.025
protein catabolic process	GO:0030163	221	0.025
proteoglycan biosynthetic process	GO:0030166	20	0.025

Nkx2-4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
bone development disease	DOID:0080006	0.123
bone disease	DOID:0080001	0.123
disease of anatomical entity	DOID:7	0.123
musculoskeletal system disease	DOID:17	0.123
connective tissue disease	DOID:65	0.123

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