Mus musculus

377 known processes

Nkx2-5

NK2 transcription factor related, locus 5 (Drosophila)

(Aliases: tinman,Csx,Nkx-2.5,Nkx2.5)

Nkx2-5 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
positive regulation of cardioblast differentiationGO:005189131.000
cardioblast migration to the midline involved in heart field formationGO:006097511.000
regulation of cardiac muscle tissue developmentGO:0055024311.000
cardiac muscle tissue developmentGO:00487381301.000
atrial ventricular junction remodelingGO:000329421.000
endodermal cell fate commitmentGO:0001711121.000
sinoatrial node cell differentiationGO:006092131.000
striated muscle tissue developmentGO:00147062931.000
cardioblast migrationGO:000326011.000
embryonic organ morphogenesisGO:00485622761.000
heart morphogenesisGO:00030071781.000
regulation of cardiac muscle cell proliferationGO:0060043231.000
endocardial cushion to mesenchymal transition involved in heart valve formationGO:000319941.000
cardiac conduction system developmentGO:0003161121.000
regulation of cardioblast differentiationGO:005189031.000
regulation of cardiac muscle tissue growthGO:0055021261.000
ventricular cardiac muscle cell action potentialGO:008600541.000
positive regulation of cardiac muscle tissue growthGO:0055023151.000
commitment of neuronal cell to specific neuron type in forebrainGO:002190271.000
mesenchyme developmentGO:00604851521.000
cardiac muscle cell proliferationGO:0060038311.000
cardiac muscle cell developmentGO:0055013391.000
tricuspid valve developmentGO:000317531.000
cardiac cell fate determinationGO:006091321.000
axon guidanceGO:00074111411.000
Mouse
ventricular cardiac muscle cell differentiationGO:0055012171.000
bundle of his developmentGO:000316641.000
cell migration to the midline involved in heart developmentGO:000331811.000
cardiocyte differentiationGO:0035051871.000
cardiac muscle tissue growthGO:0055017371.000
septum transversum developmentGO:000334321.000
cardiac chamber developmentGO:00032051081.000
mitral valve morphogenesisGO:000318341.000
av node cell to bundle of his cell communicationGO:008606721.000
regionalizationGO:00030023371.000
septum primum developmentGO:000328441.000
endodermal cell fate specificationGO:000171441.000
embryonic heart tube left right pattern formationGO:006097151.000
cardiac septum developmentGO:0003279591.000
Human
cardiac chamber morphogenesisGO:0003206931.000
atrial septum primum morphogenesisGO:000328931.000
cardiac muscle cell differentiationGO:0055007691.000
heart growthGO:0060419451.000
pituitary gland developmentGO:0021983381.000
Mouse
positive regulation of transcription from rna polymerase ii promoter involved in myocardial precursor cell differentiationGO:000325731.000
clara cell differentiationGO:006048641.000
Mouse
positive regulation of cardiac muscle cell proliferationGO:0060045151.000
atrioventricular valve morphogenesisGO:0003181131.000
atrial septum developmentGO:0003283121.000
Human
forebrain neuron fate commitmentGO:0021877131.000
Mouse
heart valve developmentGO:0003170231.000
epithelial tube morphogenesisGO:00605623031.000
heart contractionGO:0060047931.000
aortic valve morphogenesisGO:000318041.000
regulation of heart growthGO:0060420311.000
ventricular septum morphogenesisGO:0060412271.000
Human
cardiac atrium developmentGO:0003230241.000
Human
embryonic heart tube anterior posterior pattern specificationGO:003505431.000
proepicardium developmentGO:000334221.000
cardiac muscle cell contractionGO:008600371.000
heart valve morphogenesisGO:0003179211.000
positive regulation of auditory receptor cell differentiationGO:004560911.000
ventricular septum developmentGO:0003281421.000
Human
regulation of cardiac muscle contractionGO:0055117211.000
atrial septum morphogenesisGO:0060413111.000
Human
muscle tissue developmentGO:00605373081.000
heart processGO:0003015940.999
determination of heart left right asymmetryGO:0061371480.999
positive regulation of heart growthGO:0060421180.999
his purkinje system cell differentiationGO:006093220.999
telencephalon developmentGO:00215371860.999
Mouse
endocardial cushion to mesenchymal transitionGO:009050050.999
notochord formationGO:001402850.999
positive regulation of striated muscle tissue developmentGO:0045844310.999
blood circulationGO:00080151950.999
positive regulation of cardiac muscle tissue developmentGO:0055025190.999
pulmonary valve developmentGO:000317750.999
striated muscle cell proliferationGO:0014855390.999
embryonic placenta developmentGO:0001892980.999
stem cell differentiationGO:00488632680.999
cardiac pacemaker cell differentiationGO:006092050.999
cell proliferation involved in outflow tract morphogenesisGO:006132540.999
positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formationGO:200080210.999
atrial cardiac muscle cell differentiationGO:005501120.999
Mouse
positive regulation of transcription from rna polymerase ii promoter involved in heart developmentGO:190122840.999
embryonic heart tube developmentGO:0035050650.999
endocardial cushion morphogenesisGO:0003203180.999
cardiac ventricle morphogenesisGO:0003208500.999
organ growthGO:00352651170.999
regulation of striated muscle contractionGO:0006942250.999
regulation of cardiac chamber formationGO:190121010.999
outflow tract morphogenesisGO:0003151530.998
embryonic heart tube morphogenesisGO:0003143510.998
cell migration involved in heart formationGO:006097410.998
neuron projection guidanceGO:00974851410.998
Mouse
specification of organ identityGO:0010092300.998
glial cell derived neurotrophic factor receptor signaling pathway involved in ureteric bud formationGO:200070110.998
mesodermal to mesenchymal transition involved in gastrulationGO:006080910.998
heart valve formationGO:0003188100.998
cardiac muscle tissue morphogenesisGO:0055008440.998
positive regulation of secondary heart field cardioblast proliferationGO:007251340.998
atrioventricular valve formationGO:000319050.998
carbon catabolite repression of transcription from rna polymerase ii promoterGO:000043710.998
sinoatrial node developmentGO:000316340.998
endocrine system developmentGO:0035270980.998
stem cell developmentGO:00488642190.998
positive regulation of inner ear receptor cell differentiationGO:200098210.998
circulatory system processGO:00030131970.998
cell communication involved in cardiac conductionGO:008606590.998
gland developmentGO:00487323300.998
negative regulation of cardiac chamber morphogenesisGO:190122020.997
ventricular cardiac muscle cell developmentGO:0055015110.997
endocardial cushion formationGO:0003272130.997
muscle tissue morphogenesisGO:0060415530.997
positive regulation of ureteric bud formationGO:007210730.997
cardiac neural crest cell migration involved in outflow tract morphogenesisGO:000325330.997
cardiac myofibril assemblyGO:0055003120.997
gabaergic neuron differentiationGO:0097154110.997
Mouse
skeletal muscle cell differentiationGO:0035914660.997
regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formationGO:200070210.997
respiratory system developmentGO:00605411900.997
Mouse
cardiac chamber formationGO:0003207100.997
muscle cell differentiationGO:00426922610.997
ventricular cardiac myofibril assemblyGO:005500530.997
cardiac septum morphogenesisGO:0060411460.997
Human
cardiac cell developmentGO:0055006410.997
embryonic heart tube formationGO:000314410.997
mitral valve developmentGO:000317440.997
lung developmentGO:00303241640.996
Mouse
cardiac muscle contractionGO:0060048320.996
foramen ovale closureGO:003592210.996
cell fate specificationGO:0001708720.996
Mouse
visceral motor neuron differentiationGO:002152430.996
cardiac muscle hypertrophy in response to stressGO:0014898100.995
cell fate commitment involved in formation of primary germ layerGO:0060795260.995
lens morphogenesis in camera type eyeGO:0002089240.995
diencephalon developmentGO:0021536630.995
Mouse
lung lobe formationGO:006046410.995
transcriptional activation by promoter enhancer loopingGO:007173320.995
heart formationGO:0060914160.995
axonogenesisGO:00074092740.995
Mouse
autonomic nervous system developmentGO:0048483430.995
megakaryocyte differentiationGO:0030219260.994
negative regulation of cell proliferationGO:00082852960.994
Mouse
regulation of ureteric bud formationGO:007210630.994
negative regulation of cardiac muscle tissue developmentGO:005502680.994
pyramidal neuron migrationGO:002185210.994
positive regulation of transcription via serum response element bindingGO:001073510.994
cardiac conductionGO:0061337170.994
fibroblast growth factor receptor signaling pathway involved in ureteric bud formationGO:200069910.994
negative regulation of glial cell derived neurotrophic factor receptor signaling pathway involved in ureteric bud formationGO:200073410.993
ventricular cardiac muscle tissue morphogenesisGO:0055010320.993
neural crest cell developmentGO:0014032480.993
regulation of organ morphogenesisGO:20000271440.993
regulation of organ growthGO:0046620610.993
atrioventricular bundle cell differentiationGO:000316710.993
trophectodermal cell differentiationGO:0001829210.993
atrioventricular valve developmentGO:0003171150.993
ventral spinal cord developmentGO:0021517480.993
Mouse
camera type eye developmentGO:00430102660.993
skeletal muscle organ developmentGO:00605381630.992
regulation of neuron differentiationGO:00456642810.992
Human Mouse
determination of left right symmetryGO:0007368800.992
regulation of skeletal muscle fiber differentiationGO:190280930.992
positive regulation of transcription from rna polymerase ii promoter involved in norepinephrine biosynthetic processGO:200076310.992
mast cell differentiationGO:006037450.992
cardiac muscle cell action potential involved in contractionGO:008600260.992
heart field specificationGO:000312860.992
muscle cell proliferationGO:0033002520.992
outflow tract septum morphogenesisGO:0003148110.992
Human
positive regulation of muscle tissue developmentGO:1901863320.992
regulation of heart contractionGO:0008016770.991
cerebral cortex neuron differentiationGO:0021895190.991
Mouse
positive regulation of nervous system developmentGO:00519622210.991
Human Mouse
endocardial cushion developmentGO:0003197260.991
cell differentiation in spinal cordGO:0021515530.990
Mouse
regulation of cell proliferation involved in mesonephros developmentGO:200060610.990
t cell activationGO:00421102890.990
Mouse
blood vessel morphogenesisGO:00485142850.990
cardiac atrium morphogenesisGO:0003209230.989
Human
sinoatrial node cell developmentGO:006093130.989
cardiac epithelial to mesenchymal transitionGO:0060317180.989
spinal cord motor neuron differentiationGO:0021522350.989
Mouse
pulmonary valve morphogenesisGO:000318450.989
regulation of cardiac chamber morphogenesisGO:190121920.989
morphogenesis of a branching structureGO:00017632030.989
cardiac ventricle developmentGO:0003231830.989
mesenchymal cell proliferation involved in ureter developmentGO:007219840.989
pancreatic pp cell fate commitmentGO:000332920.989
Mouse
thyroid stimulating hormone secreting cell differentiationGO:006012940.988
cardiac left ventricle morphogenesisGO:000321490.988
ear developmentGO:00435832000.988
Mouse
nephron epithelium morphogenesisGO:0072088680.988
positive regulation of transcription elongation from rna polymerase ii promoterGO:003296820.987
telencephalon regionalizationGO:0021978140.987
mesoderm morphogenesisGO:0048332640.986
nephron morphogenesisGO:0072028690.986
forebrain neuron differentiationGO:0021879520.986
Mouse
cell type specific apoptotic processGO:00972852680.986
regulation of forebrain neuron differentiationGO:200097720.986
response to retinoic acidGO:0032526560.986
digestive system developmentGO:00551232000.986
Mouse Worm
regulation of gliogenesisGO:0014013500.986
Mouse
ventricular cardiac muscle tissue developmentGO:0003229380.986
cardiac left ventricle formationGO:000321810.985
regulation of endocardial cushion to mesenchymal transition involved in heart valve formationGO:200080010.985
hindbrain developmentGO:00309021280.984
cell fate commitmentGO:00451652100.984
blastocyst formationGO:0001825330.984
mammary gland morphogenesisGO:0060443540.983
oligodendrocyte developmentGO:0014003200.983
Mouse
gene loopingGO:009020220.983
negative regulation of cardiac chamber formationGO:190121110.983
negative regulation of neuron differentiationGO:00456651010.983
Mouse
mesodermal cell migrationGO:000807840.982
forebrain regionalizationGO:0021871250.982
Mouse
lung cell differentiationGO:0060479300.981
Mouse
cardiac ventricle formationGO:000321180.981
mesenchymal cell developmentGO:0014031930.980
muscle system processGO:00030121410.980
chemotaxisGO:00069352470.980
Mouse
formation of primary germ layerGO:0001704770.979
cerebral cortex developmentGO:0021987860.979
Mouse
auditory receptor cell fate determinationGO:004266830.979
neural crest cell differentiationGO:0014033540.979
branching involved in mammary gland duct morphogenesisGO:0060444270.978
epithelial cell proliferationGO:00506731740.978
Mouse
neural crest cell migrationGO:0001755320.978
skeletal system developmentGO:00015013560.978
Mouse
secondary heart field specificationGO:000313960.978
regulation of cardiac muscle cell contractionGO:0086004110.978
glandular epithelial cell differentiationGO:0002067380.978
Mouse
negative regulation of canonical wnt signaling pathway involved in neural plate anterior posterior pattern formationGO:006082910.978
digestive tract morphogenesisGO:00485461470.977
Mouse
vagus nerve developmentGO:002156430.977
mesenchymal cell differentiationGO:00487621070.977
negative regulation of muscle cell apoptotic processGO:001065690.977
hemangioblast cell differentiationGO:006021710.977
coronary vasculature developmentGO:0060976120.976
embryonic skeletal system developmentGO:00487061200.976
Mouse
cardiac right ventricle formationGO:000321930.975
enamel mineralizationGO:007016670.975
response to fibroblast growth factorGO:0071774470.974
aorta morphogenesisGO:0035909220.974
pallium developmentGO:00215431200.974
Mouse
negative regulation of mesodermal cell fate specificationGO:004266230.974
appendage morphogenesisGO:00351071490.974
nodal signaling pathway involved in determination of left right asymmetryGO:003810720.974
regulation of renin secretion into blood streamGO:190013340.974
sa node cell to atrial cardiac muscle cell signallingGO:008601840.973
epidermis developmentGO:00085441870.973
cell communication by electrical coupling involved in cardiac conductionGO:008606420.972
leukocyte differentiationGO:00025213420.972
Mouse
negative regulation of heart loopingGO:190120810.972
positive regulation of glial cell differentiationGO:0045687210.972
Mouse
ear morphogenesisGO:00424711180.972
Mouse
morphogenesis of a branching epitheliumGO:00611381930.971
bone morphogenesisGO:0060349780.971
regulation of striated muscle cell differentiationGO:0051153810.971
Human
alpha beta t cell differentiationGO:0046632690.971
Mouse
regulation of ventricular cardiac muscle cell membrane depolarizationGO:006037320.971
regulation of organ formationGO:0003156340.970
muscle adaptationGO:0043500390.970
regulation of tongue muscle cell differentiationGO:200103520.970
endoderm formationGO:0001706200.970
embryonic epithelial tube formationGO:00018381300.970
positive regulation of skeletal muscle fiber differentiationGO:190281120.970
cardiac pacemaker cell developmentGO:006092650.970
negative regulation of wnt signaling pathwayGO:0030178730.968
positive regulation of skeletal muscle cell differentiationGO:200101640.968
negative regulation of wnt signaling pathway involved in heart developmentGO:000330840.968
regulation of heart morphogenesisGO:2000826220.967
digestive tract developmentGO:00485651900.967
Mouse Worm
cell differentiation involved in embryonic placenta developmentGO:0060706260.967
heart trabecula formationGO:0060347140.966
embryonic eye morphogenesisGO:0048048290.966
epithelial to mesenchymal transition involved in endocardial cushion formationGO:0003198100.966
regulation of definitive erythrocyte differentiationGO:001072430.966
semaphorin plexin signaling pathway involved in outflow tract morphogenesisGO:007152710.965
regulation of auditory receptor cell differentiationGO:004560740.965
epithelial tube formationGO:00721751300.965
cardiac cell fate commitmentGO:0060911100.965
regulation of glial cell differentiationGO:0045685410.964
Mouse
nephron tubule morphogenesisGO:0072078680.963
nephron tubule epithelial cell differentiationGO:0072160110.963
negative regulation of gastrulationGO:200054230.963
definitive erythrocyte differentiationGO:006031870.963
sensory organ morphogenesisGO:00905962420.962
Mouse
limbic system developmentGO:0021761720.962
Mouse
positive regulation of tongue muscle cell differentiationGO:200103720.961
regulation of cell activationGO:00508652890.960
mesonephric tubule morphogenesisGO:0072171630.960
astrocyte fate commitmentGO:006001840.960
regulation of cardioblast proliferationGO:000326490.960
somite rostral caudal axis specificationGO:0032525130.959
regulation of transcription from rna polymerase ii promoter involved in myocardial precursor cell differentiationGO:000325660.959
pulmonary valve formationGO:000319310.959
lens development in camera type eyeGO:0002088620.958
cell proliferation in hindbrainGO:0021534100.958
thymus developmentGO:0048538410.957
regulation of endodermal cell differentiationGO:190322420.956
cell migration involved in gastrulationGO:0042074130.956
regulation of muscle tissue developmentGO:1901861970.956
negative regulation of neuron projection developmentGO:0010977500.956
muscle cell developmentGO:00550011330.954
positive regulation of heart rateGO:0010460100.954
t cell differentiationGO:00302171740.954
Mouse
endodermal cell fate determinationGO:000749320.953
respiratory tube developmentGO:00303231670.953
Mouse
lung epithelial cell differentiationGO:0060487290.952
Mouse
endoderm developmentGO:0007492450.951
Mouse
positive regulation of mechanoreceptor differentiationGO:004563310.951
regulation of canonical wnt signaling pathway involved in neural plate anterior posterior pattern formationGO:006082710.950
nodal signaling pathway involved in determination of lateral mesoderm left right asymmetryGO:190016420.950
regulation of nephron tubule epithelial cell differentiationGO:007218290.949
sa node cell action potentialGO:008601540.949
positive regulation of semaphorin plexin signaling pathway involved in outflow tract morphogenesisGO:200076410.948
parathyroid hormone secretionGO:003589820.948
striated muscle cell developmentGO:00550021250.948
negative regulation of nervous system developmentGO:00519611560.947
Mouse
cell adhesionGO:00071553290.947
negative regulation of macrophage differentiationGO:004565040.947
mesenchymal cell proliferationGO:0010463440.946
limb developmentGO:00601731660.945
cerebral cortex cell migrationGO:0021795440.945
Mouse
coronary vasculature morphogenesisGO:006097790.945
urogenital system developmentGO:00016552610.944
erythrocyte differentiationGO:0030218880.944
regulation of glial cell derived neurotrophic factor receptor signaling pathway involved in ureteric bud formationGO:200073310.943
specification of organ positionGO:001015930.943
positive regulation of mesenchymal cell proliferationGO:0002053330.943
ureter maturationGO:003579940.941
canonical wnt signaling pathway involved in neural plate anterior posterior pattern formationGO:006082310.941
negative regulation of cardiac muscle cell proliferationGO:006004450.941
oligodendrocyte differentiationGO:0048709530.941
Mouse
atrioventricular node cell differentiationGO:006092220.939
face morphogenesisGO:0060325290.939
wnt signaling pathway involved in kidney developmentGO:006128920.938
stem cell maintenanceGO:00198271300.937
mesoderm formationGO:0001707620.937
regulation of blood circulationGO:1903522930.936
neural tube closureGO:0001843900.936
regulation of neuron maturationGO:001404150.936
visceral serous pericardium developmentGO:006103220.936
apoptotic process involved in outflow tract morphogenesisGO:000327520.936
tendon cell differentiationGO:003599040.936
cranial nerve developmentGO:0021545410.936
forebrain developmentGO:00309003020.935
Mouse
spinal cord developmentGO:0021510810.935
Mouse
ventricular trabecula myocardium morphogenesisGO:0003222110.935
central nervous system neuron differentiationGO:00219531620.934
Mouse
cardiac right ventricle morphogenesisGO:0003215130.933
Human
renal vesicle developmentGO:0072087170.933
regulation of mast cell differentiationGO:006037530.933
glial cell developmentGO:0021782540.933
Mouse
positive regulation of epithelial cell proliferation involved in lung morphogenesisGO:006050130.933
regulation of heart loopingGO:190120710.932
his purkinje system developmentGO:000316440.931
ameboidal type cell migrationGO:00016671280.931
milk ejectionGO:006015610.930
lymphocyte differentiationGO:00300982420.930
Mouse
positive regulation of neuron differentiationGO:00456661410.930
Human Mouse
cardiac muscle adaptationGO:0014887100.930
regulation of membrane depolarizationGO:0003254110.929
cell fate determinationGO:0001709320.928
Mouse
otic vesicle developmentGO:0071599140.928
forebrain generation of neuronsGO:0021872630.928
Mouse
positive regulation of epithelial cell proliferationGO:0050679680.928
neuron migrationGO:00017641220.928
Mouse
metanephric capsule specificationGO:007226710.927
hypothalamus developmentGO:0021854160.927
Mouse
enteroendocrine cell differentiationGO:0035883160.927
Mouse
spleen developmentGO:0048536390.927
cardiac muscle cell fate commitmentGO:006092360.927
regulation of epithelial cell proliferationGO:00506781410.926
Mouse
atrioventricular node cell developmentGO:006092820.926
atrial cardiac muscle cell developmentGO:005501420.925
Mouse
regulation of cell proliferation involved in heart morphogenesisGO:2000136150.924
endodermal cell differentiationGO:0035987140.924
muscle hypertrophyGO:0014896240.924
columnar cuboidal epithelial cell differentiationGO:0002065820.923
Mouse
regulation of membrane depolarization during cardiac muscle cell action potentialGO:190082510.923
male sex differentiationGO:00466611090.921
Mouse
mammary gland duct morphogenesisGO:0060603380.921
negative regulation of embryonic developmentGO:0045992220.920
platelet morphogenesisGO:0036344130.920
regulation of wnt signaling pathwayGO:00301111230.919
aortic valve developmentGO:000317650.919
cell migration involved in heart developmentGO:006097380.918
regulation of transcription from rna polymerase ii promoter involved in determination of left right symmetryGO:190009420.916
auditory receptor cell fate specificationGO:004266710.915
myelinationGO:0042552740.915
cation homeostasisGO:00550802120.915
closure of optic fissureGO:006138620.913
regulation of apoptotic process involved in outflow tract morphogenesisGO:190225620.913
ureteric bud morphogenesisGO:0060675620.913
somitogenesisGO:0001756690.913
kidney morphogenesisGO:0060993830.912
cellular response to follicle stimulating hormone stimulusGO:007137210.909
regulation of neuron projection developmentGO:00109751690.909
cell communication by chemical couplingGO:001064320.908
myotube differentiationGO:00149021050.908
Human
fibroblast growth factor receptor signaling pathwayGO:0008543460.907
atrioventricular canal developmentGO:003630250.906
actin mediated cell contractionGO:0070252150.906
vascular smooth muscle cell differentiationGO:0035886110.906
negative regulation of apoptotic process involved in outflow tract morphogenesisGO:190225720.904
purkinje myocyte differentiationGO:000316810.904
embryonic camera type eye developmentGO:0031076360.903
regulation of cell migrationGO:00303342190.903
negative regulation of epithelial cell proliferationGO:0050680640.903
Mouse
regulation of atrial cardiac muscle cell membrane depolarizationGO:006037150.901
lung saccule developmentGO:006043070.901
Mouse
renal capsule specificationGO:007213010.897
embryonic viscerocranium morphogenesisGO:004870380.897
tube formationGO:00351481400.895
negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formationGO:200070310.895
notochord developmentGO:0030903200.895
renal system developmentGO:00720012250.895
placenta developmentGO:00018901400.893
regulation of transcription involved in primary germ layer cell fate commitmentGO:006079620.893
positive regulation of blood circulationGO:1903524220.893
cardiac muscle cell myoblast differentiationGO:006037980.891
myofibril assemblyGO:0030239340.890
hindlimb morphogenesisGO:0035137420.888
tongue developmentGO:0043586180.887
Mouse
regulation of canonical wnt signaling pathwayGO:0060828820.885
myeloid cell homeostasisGO:00022621140.884
branching morphogenesis of an epithelial tubeGO:00487541590.883
cardiac muscle cell action potentialGO:0086001110.883
olfactory bulb developmentGO:0021772300.883
cellular response to fibroblast growth factor stimulusGO:0044344470.880
positive regulation of stem cell differentiationGO:2000738230.879
spinal cord oligodendrocyte cell differentiationGO:002152930.878
Mouse
cell differentiation involved in kidney developmentGO:0061005330.877
regulation of secondary heart field cardioblast proliferationGO:000326690.877
positive regulation of transcription regulatory region dna bindingGO:200067910.875
negative regulation of mesenchymal cell apoptotic processGO:2001054110.874
mesenchyme morphogenesisGO:0072132320.871
lung inductionGO:006049230.871
regulation of histone h3 k4 methylationGO:0051569120.869
muscle contractionGO:00069361010.867
mesodermal cell fate commitmentGO:0001710170.867
cellular response to retinoic acidGO:0071300250.867
pancreatic a cell differentiationGO:000331070.867
Mouse
vagus nerve morphogenesisGO:002164420.866
olfactory lobe developmentGO:0021988320.865
tendon formationGO:003599240.864
glial cell fate commitmentGO:0021781140.864
Mouse
positive regulation of mesenchymal cell proliferation involved in ureter developmentGO:200072930.864
regulation of epithelial cell differentiation involved in kidney developmentGO:2000696100.863
positive regulation of transcription from rna polymerase ii promoter by glucoseGO:000043230.863
hepaticobiliary system developmentGO:0061008670.861
primary prostatic bud elongationGO:006051620.859
central nervous system morphogenesisGO:002155120.859
bmp signaling pathwayGO:0030509930.859
forelimb morphogenesisGO:0035136400.859
detection of external stimulusGO:0009581610.857
comma shaped body morphogenesisGO:007204950.857
regulation of transcription from rna polymerase ii promoter involved in ventral spinal cord interneuron specificationGO:002191340.855
positive regulation of cell activationGO:00508671580.854
septum secundum developmentGO:000328510.854
Human
developmental growth involved in morphogenesisGO:00605601380.853
retinoic acid receptor signaling pathwayGO:0048384170.852
mammary placode formationGO:006059640.852
regulation of heart rateGO:0002027360.851
negative regulation of neural precursor cell proliferationGO:2000178180.851
renal tubule morphogenesisGO:0061333720.849
head morphogenesisGO:0060323340.847
skeletal muscle fiber developmentGO:0048741580.847
positive regulation of transcription by glucoseGO:004601630.847
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781940.846
cell surface receptor signaling pathway involved in heart developmentGO:0061311150.845
positive regulation of protein phosphorylationGO:00019342420.845
wnt signaling pathwayGO:00160551880.845
epithelial cell differentiation involved in kidney developmentGO:0035850230.845
odontogenesis of dentin containing toothGO:0042475660.844
Mouse
response to bmpGO:0071772140.843
nephric duct formationGO:007217940.843
morphogenesis of embryonic epitheliumGO:00163311590.843
regulation of myotube differentiationGO:0010830620.841
Human
regulation of epidermal cell differentiationGO:0045604210.841
regulation of endodermal cell fate specificationGO:004266320.840
type ii pneumocyte differentiationGO:006051070.840
Mouse
regulation of system processGO:00440572000.838
regulation of osteoblast differentiationGO:0045667670.836
tongue muscle cell differentiationGO:003598120.836
pulmonary myocardium developmentGO:000335030.836
skeletal system morphogenesisGO:00487052030.835
Mouse
negative regulation of sequence specific dna binding transcription factor activityGO:0043433400.835
tongue morphogenesisGO:004358780.834
regulation of membrane depolarization during action potentialGO:009890210.834
left right pattern formationGO:0060972230.832

Nkx2-5 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
heart diseaseDOID:11400.999
Human
disease of anatomical entityDOID:700.999
Human
cardiovascular system diseaseDOID:128700.999
Human
congenital heart diseaseDOID:168200.987
Human
heart septal defectDOID:168100.987
Human
ventricular septal defectDOID:165700.987
Human