Mus musculus

0 known processes

Top3a

topoisomerase (DNA) III alpha

(Aliases: MGC106383)

Top3a biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
dna metabolic processGO:00062593030.170
Human Worm
regulation of cell cycleGO:00517262810.055
nuclear divisionGO:00002801580.055
Worm
apoptotic signaling pathwayGO:00971903060.044
transmembrane transportGO:00550854120.041
cellular response to dna damage stimulusGO:00069742070.039
lymphocyte differentiationGO:00300982420.039
purine ribonucleotide metabolic processGO:00091502900.037
leukocyte differentiationGO:00025213420.037
purine nucleotide metabolic processGO:00061633020.034
glycosyl compound catabolic processGO:19016582060.034
male gamete generationGO:00482322850.033
rna processingGO:00063961050.033
meiotic cell cycleGO:00513211220.032
Worm
immune effector processGO:00022523210.031
dna repairGO:00062811070.030
positive regulation of cell deathGO:00109422240.030
regulation of mapk cascadeGO:00434082480.029
cellular amino acid metabolic processGO:00065201030.029
dna recombinationGO:0006310920.028
nucleobase containing small molecule metabolic processGO:00550863520.028
cellular macromolecule catabolic processGO:00442652060.028
protein modification by small protein conjugation or removalGO:00706472070.027
purine containing compound metabolic processGO:00725213110.027
organophosphate catabolic processGO:00464342320.027
chromatin organizationGO:00063252060.027
heterocycle catabolic processGO:00467002800.027
cytoplasmic transportGO:00164822340.027
protein processingGO:00164851630.027
double strand break repairGO:0006302480.027
meiotic nuclear divisionGO:00071261150.027
Worm
negative regulation of protein metabolic processGO:00512482820.026
ribonucleoside metabolic processGO:00091192450.026
aromatic compound catabolic processGO:00194392860.026
ribonucleotide metabolic processGO:00092592910.026
organelle fissionGO:00482851700.025
Worm
purine ribonucleotide catabolic processGO:00091542080.025
protein localization to organelleGO:00333651850.025
positive regulation of apoptotic processGO:00430652170.025
nucleoside triphosphate catabolic processGO:00091432050.025
purine nucleoside catabolic processGO:00061522050.025
purine containing compound catabolic processGO:00725232130.025
digestive tract morphogenesisGO:00485461470.024
b cell activationGO:00421131610.024
regulation of organelle organizationGO:00330432890.024
negative regulation of cellular protein metabolic processGO:00322692470.024
regulation of cell activationGO:00508652890.023
positive regulation of programmed cell deathGO:00430682180.023
t cell activationGO:00421102890.023
cellular ketone metabolic processGO:0042180840.023
fucosylationGO:003606590.023
maintenance of locationGO:0051235890.023
purine nucleoside metabolic processGO:00422782410.023
nucleoside phosphate catabolic processGO:19012922220.022
male meiosisGO:0007140370.022
regulation of proteolysisGO:00301621640.022
organic cyclic compound catabolic processGO:19013612950.022
mitotic cell cycleGO:00002781950.022
nucleoside metabolic processGO:00091162460.022
reactive oxygen species metabolic processGO:0072593840.022
cytokine productionGO:00018163190.022
glycosyl compound metabolic processGO:19016572460.022
posttranscriptional regulation of gene expressionGO:00106081550.022
intracellular protein transportGO:00068862040.022
mitotic cell cycle processGO:19030471590.022
regulation of cellular ketone metabolic processGO:0010565660.022
nucleoside catabolic processGO:00091642060.022
cellularizationGO:000734910.022
nucleotide metabolic processGO:00091173320.021
purine nucleotide catabolic processGO:00061952110.021
cellular nitrogen compound catabolic processGO:00442702800.021
nucleoside triphosphate metabolic processGO:00091412300.021
germ cell developmentGO:00072811850.021
Worm
anatomical structure homeostasisGO:00602491450.021
positive regulation of cellular amino acid metabolic processGO:004576430.021
rna splicingGO:0008380540.021
macromolecule catabolic processGO:00090572810.021
mapk cascadeGO:00001652810.020
nucleoside phosphate metabolic processGO:00067533380.020
spermatid developmentGO:00072861080.020
regulation of apoptotic signaling pathwayGO:20012331970.020
positive regulation of cellular amine metabolic processGO:003324050.020
chromatin modificationGO:00165681870.020
leukocyte mediated immunityGO:00024431740.020
mrna metabolic processGO:0016071840.020
mrna processingGO:0006397630.020
regulation of cytokine productionGO:00018172660.020
ribonucleoside triphosphate catabolic processGO:00092031990.020
ribose phosphate metabolic processGO:00196932910.020
regulation of hydrolase activityGO:00513362460.020
meiotic cell cycle processGO:1903046770.020
regulation of cysteine type endopeptidase activityGO:2000116650.020
meiosis iGO:0007127600.020
carbohydrate derivative catabolic processGO:19011362310.019
regulation of lymphocyte activationGO:00512492400.019
nucleocytoplasmic transportGO:00069131390.019
methylationGO:00322591340.019
oocyte constructionGO:000730820.018
digestive system developmentGO:00551232000.018
microtubule based processGO:00070172360.018
protein maturationGO:00516041760.018
purine ribonucleoside metabolic processGO:00461282410.018
macromolecule methylationGO:00434141200.018
development of primary sexual characteristicsGO:00451371430.017
positive regulation of protein phosphorylationGO:00019342420.017
ribonucleoside triphosphate metabolic processGO:00091992200.017
dephosphorylationGO:00163111290.017
response to molecule of bacterial originGO:00022371430.017
regulation of kinase activityGO:00435492490.017
organelle localizationGO:00516401790.017
compound eye developmentGO:004874910.017
sensory organ morphogenesisGO:00905962420.016
innate immune responseGO:00450871570.016
response to lipopolysaccharideGO:00324961280.016
nuclear transportGO:00511691390.016
regulation of transferase activityGO:00513382630.016
positive regulation of endopeptidase activityGO:0010950430.016
nuclear importGO:0051170950.016
ribonucleoside catabolic processGO:00424542060.016
purine nucleoside triphosphate metabolic processGO:00091442260.016
rna splicing via transesterification reactions with bulged adenosine as nucleophileGO:0000377430.016
bone developmentGO:00603481200.016
purine ribonucleoside triphosphate metabolic processGO:00092052200.016
purine nucleoside triphosphate catabolic processGO:00091462030.016
establishment or maintenance of cytoskeleton polarityGO:003095220.016
regulation of cellular response to stressGO:00801351590.016
oocyte axis specificationGO:000730920.015
positive regulation of protein modification processGO:00314012990.015
intrinsic apoptotic signaling pathwayGO:00971931320.015
blastocyst developmentGO:0001824800.015
positive regulation of protein kinase activityGO:00458601440.015
regulation of bindingGO:00510981110.015
progesterone metabolic processGO:004244840.015
negative regulation of proteolysisGO:0045861740.015
regulation of cell cycle processGO:00105641600.015
negative regulation of molecular functionGO:00440922580.015
retina development in camera type eyeGO:00600411190.015
rna splicing via transesterification reactionsGO:0000375430.015
proteasome mediated ubiquitin dependent protein catabolic processGO:0043161880.015
cation transmembrane transportGO:00986552660.015
ribonucleotide catabolic processGO:00092612080.015
regulation of protein processingGO:0070613960.015
small molecule biosynthetic processGO:00442831320.015
gonad developmentGO:00084061410.015
nitrogen compound transportGO:00717052710.015
regulation of cell cycle phase transitionGO:1901987770.015
regulation of endopeptidase activityGO:0052548890.014
ion transmembrane transportGO:00342203610.014
regulation of mitotic cell cycle phase transitionGO:1901990730.014
rhythmic processGO:00485111740.014
microtubule cytoskeleton organizationGO:00002261570.014
purine ribonucleoside triphosphate catabolic processGO:00092071990.014
respiratory tube developmentGO:00303231670.014
cation transportGO:00068123990.014
small gtpase mediated signal transductionGO:0007264970.014
regulation of lymphocyte proliferationGO:00506701170.014
modification dependent protein catabolic processGO:00199411330.014
negative regulation of cellular component organizationGO:00511291940.014
spermatogenesisGO:00072832840.014
purine ribonucleoside catabolic processGO:00461302050.014
single organism nuclear importGO:1902593950.014
camera type eye developmentGO:00430102660.014
regulation of intrinsic apoptotic signaling pathwayGO:2001242610.014
regulation of multi organism processGO:00439001110.014
inorganic ion transmembrane transportGO:00986602340.014
carboxylic acid biosynthetic processGO:0046394860.013
negative regulation of organelle organizationGO:0010639900.013
membrane organizationGO:00610242450.013
skeletal system developmentGO:00015013560.013
cilium morphogenesisGO:00602711020.013
rna interferenceGO:001624620.013
negative regulation of immune system processGO:00026832090.013
purine ribonucleoside monophosphate metabolic processGO:0009167800.013
cellular amine metabolic processGO:0044106440.013
interleukin 8 productionGO:003263740.013
mesodermal cell migrationGO:000807840.013
organonitrogen compound catabolic processGO:19015652640.013
regulation of lymphocyte mediated immunityGO:0002706840.013
positive regulation of lymphocyte activationGO:00512511400.013
fertilizationGO:00095661270.013
ribonucleoside monophosphate metabolic processGO:0009161800.013
homeostasis of number of cellsGO:00488722100.013
regulation of reactive oxygen species metabolic processGO:2000377400.013
ribonucleoprotein complex subunit organizationGO:0071826280.013
regulation of synaptic growth at neuromuscular junctionGO:000858240.012
respiratory system developmentGO:00605411900.012
intracellular mrna localizationGO:000829840.012
atp catabolic processGO:0006200550.012
mrna splicing via spliceosomeGO:0000398430.012
endocytosisGO:00068971680.012
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:00024601450.012
regulation of protein kinase activityGO:00458592320.012
positive regulation of transferase activityGO:00513471670.012
cellular protein complex assemblyGO:00436231160.012
lipid localizationGO:00108761260.012
stem cell differentiationGO:00488632680.012
regulation of protein maturationGO:1903317960.012
chromosome segregationGO:0007059480.012
spermatid differentiationGO:00485151150.012
cellular response to lipidGO:00713961450.012
response to organic cyclic compoundGO:00140701980.012
regulation of mitotic cell cycleGO:00073461260.012
response to organonitrogen compoundGO:00102432460.012
proteolysis involved in cellular protein catabolic processGO:00516031470.012
nucleotide catabolic processGO:00091662170.012
protein localization to nucleusGO:00345041210.012
regulation of cellular catabolic processGO:00313292420.012
regulation of purine nucleotide metabolic processGO:19005421690.012
positive regulation of cell activationGO:00508671580.012
regulation of protein transportGO:00512231630.012
establishment of protein localization to organelleGO:00725941180.012
nucleic acid phosphodiester bond hydrolysisGO:0090305490.012
cilium assemblyGO:0042384810.012
cellular response to lipopolysaccharideGO:0071222770.011
organelle assemblyGO:00709251770.011
nucleoside monophosphate catabolic processGO:0009125590.011
protein ubiquitinationGO:00165671710.011
regulation of membrane potentialGO:00423911920.011
negative regulation of apoptotic signaling pathwayGO:20012341040.011
regulation of cellular amine metabolic processGO:0033238200.011
multicellular organismal homeostasisGO:00488711640.011
organonitrogen compound biosynthetic processGO:19015661920.011
cellular response to biotic stimulusGO:0071216920.011
regulation of cell cell adhesion mediated by cadherinGO:200004720.011
protein importGO:00170381010.011
glucose metabolic processGO:0006006920.011
protein modification by small protein conjugationGO:00324461870.011
developmental maturationGO:00217001930.011
signal transduction involved in dna damage checkpointGO:007242230.011
lipid biosynthetic processGO:00086101790.011
positive regulation of hydrolase activityGO:00513451480.011
myeloid cell differentiationGO:00300992330.011
regulation of b cell activationGO:0050864810.011
ribonucleoprotein complex disassemblyGO:003298830.011
negative regulation of phosphorylationGO:00423261660.011
purine ribonucleoside monophosphate catabolic processGO:0009169570.011
positive regulation of mapk cascadeGO:00434101700.011
b cell differentiationGO:0030183780.011
oocyte anterior posterior axis specificationGO:000731420.011
oxidation reduction processGO:00551143420.010
immunoglobulin productionGO:0002377730.010
response to inorganic substanceGO:0010035960.010
ossificationGO:00015032160.010
regionalizationGO:00030023370.010
activation of immune responseGO:00022531380.010
regulation of leukocyte differentiationGO:19021051590.010
positive regulation of nervous system developmentGO:00519622210.010
response to radiationGO:00093141650.010
myeloid cell homeostasisGO:00022621140.010
regulation of neuron differentiationGO:00456642810.010
lymphocyte mediated immunityGO:00024491390.010
maternal determination of anterior posterior axis embryoGO:000835820.010
ribonucleoside monophosphate catabolic processGO:0009158570.010
blood circulationGO:00080151950.010
organic hydroxy compound metabolic processGO:19016152030.010
purine nucleoside monophosphate metabolic processGO:0009126810.010
positive regulation of proteolysisGO:0045862850.010
purine nucleoside monophosphate catabolic processGO:0009128580.010
molting cycleGO:0042303900.010
male meiosis iGO:0007141160.010
sensory perceptionGO:00076002450.010
negative regulation of cell sizeGO:004579230.010
monocarboxylic acid metabolic processGO:00327871910.010
leukocyte proliferationGO:00706611720.010

Top3a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.026
nervous system diseaseDOID:86300.026
cancerDOID:16200.025
disease of cellular proliferationDOID:1456600.025
organ system cancerDOID:005068600.024
musculoskeletal system diseaseDOID:1700.019
disease of metabolismDOID:001466700.018
inherited metabolic disorderDOID:65500.018
hematopoietic system diseaseDOID:7400.018
immune system diseaseDOID:291400.018
retinal diseaseDOID:567900.015
sensory system diseaseDOID:005015500.015
eye diseaseDOID:561400.015
eye and adnexa diseaseDOID:149200.015
urinary system cancerDOID:399600.014
renal cell carcinomaDOID:445000.014
renal carcinomaDOID:445100.014
kidney cancerDOID:26300.014
retinal degenerationDOID:846600.013
central nervous system diseaseDOID:33100.010