Mus musculus

0 known processes

Mdc1

mediator of DNA damage checkpoint 1

(Aliases: 6820401C03,mKIAA0170,Nfbd1,AA413496)

Mdc1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
dna repairGO:00062811070.273
dna metabolic processGO:00062593030.201
Mouse
cellular response to dna damage stimulusGO:00069742070.163
Mouse
dna recombinationGO:0006310920.069
Mouse
regulation of cellular amino acid metabolic processGO:000652150.064
cellular macromolecule catabolic processGO:00442652060.063
protein modification by small protein conjugation or removalGO:00706472070.062
Mouse
apoptotic signaling pathwayGO:00971903060.060
cellular amine metabolic processGO:0044106440.058
cellular amino acid metabolic processGO:00065201030.056
production of molecular mediator of immune responseGO:00024401030.053
Mouse
positive regulation of cellular amino acid metabolic processGO:004576430.052
amine metabolic processGO:0009308450.051
immune effector processGO:00022523210.048
Mouse
adaptive immune responseGO:00022501550.043
Mouse
protein modification by small protein conjugationGO:00324461870.043
Mouse
aromatic compound catabolic processGO:00194392860.042
heterocycle catabolic processGO:00467002800.041
organic cyclic compound catabolic processGO:19013612950.038
nucleobase containing small molecule metabolic processGO:00550863520.037
lymphocyte mediated immunityGO:00024491390.036
Mouse
purine ribonucleotide metabolic processGO:00091502900.036
b cell activation involved in immune responseGO:0002312500.034
Mouse
regulation of cellular amine metabolic processGO:0033238200.034
protein ubiquitinationGO:00165671710.034
Mouse
cellular nitrogen compound catabolic processGO:00442702800.033
cellular ketone metabolic processGO:0042180840.033
maintenance of locationGO:0051235890.033
b cell activationGO:00421131610.033
Mouse
somatic diversification of immune receptorsGO:0002200530.033
Mouse
lipid biosynthetic processGO:00086101790.032
purine containing compound metabolic processGO:00725213110.032
immunoglobulin mediated immune responseGO:0016064690.032
Mouse
purine nucleoside metabolic processGO:00422782410.031
glycosyl compound catabolic processGO:19016582060.031
organelle fissionGO:00482851700.031
isotype switchingGO:0045190360.030
Mouse
ribonucleoside metabolic processGO:00091192450.030
regulation of cellular response to stressGO:00801351590.030
regulation of cellular ketone metabolic processGO:0010565660.029
double strand break repairGO:0006302480.029
response to organonitrogen compoundGO:00102432460.029
ribonucleotide metabolic processGO:00092592910.029
cellular lipid metabolic processGO:00442553230.029
nuclear divisionGO:00002801580.029
positive regulation of cellular amine metabolic processGO:003324050.029
regulation of hydrolase activityGO:00513362460.028
purine nucleoside triphosphate catabolic processGO:00091462030.028
anatomical structure homeostasisGO:00602491450.028
purine ribonucleoside triphosphate metabolic processGO:00092052200.028
purine nucleoside triphosphate metabolic processGO:00091442260.027
macromolecule catabolic processGO:00090572810.027
somatic recombination of immunoglobulin gene segmentsGO:0016447420.027
Mouse
organophosphate catabolic processGO:00464342320.026
nucleoside phosphate metabolic processGO:00067533380.026
purine ribonucleoside catabolic processGO:00461302050.026
blastocyst growthGO:0001832230.025
organonitrogen compound catabolic processGO:19015652640.025
cation transportGO:00068123990.025
ribonucleoside catabolic processGO:00424542060.025
nucleotide metabolic processGO:00091173320.025
methylationGO:00322591340.024
Mouse
histone modificationGO:00165701590.024
Mouse
glycosyl compound metabolic processGO:19016572460.024
regulation of apoptotic signaling pathwayGO:20012331970.024
ribonucleoside triphosphate catabolic processGO:00092031990.024
nucleoside metabolic processGO:00091162460.023
carbohydrate derivative catabolic processGO:19011362310.023
negative regulation of cellular amine metabolic processGO:003323910.023
cellular response to organonitrogen compoundGO:00714171450.023
response to radiationGO:00093141650.023
organonitrogen compound biosynthetic processGO:19015661920.023
nucleoside phosphate catabolic processGO:19012922220.023
intrinsic apoptotic signaling pathwayGO:00971931320.023
purine nucleotide metabolic processGO:00061633020.023
purine nucleoside catabolic processGO:00061522050.022
purine ribonucleotide catabolic processGO:00091542080.022
ribonucleoside triphosphate metabolic processGO:00091992200.022
leukocyte mediated immunityGO:00024431740.022
Mouse
negative regulation of cell proliferationGO:00082852960.022
nucleoside triphosphate catabolic processGO:00091432050.022
regulation of membrane potentialGO:00423911920.021
nucleotide catabolic processGO:00091662170.021
nucleoside catabolic processGO:00091642060.021
cilium morphogenesisGO:00602711020.021
positive regulation of apoptotic processGO:00430652170.021
small molecule biosynthetic processGO:00442831320.021
nucleoside triphosphate metabolic processGO:00091412300.021
protein maturationGO:00516041760.021
microtubule based processGO:00070172360.021
negative regulation of molecular functionGO:00440922580.021
positive regulation of hydrolase activityGO:00513451480.021
lymphocyte activation involved in immune responseGO:0002285930.021
Mouse
purine ribonucleoside metabolic processGO:00461282410.021
cellular protein catabolic processGO:00442571550.020
chromosome segregationGO:0007059480.020
somatic diversification of immune receptors via germline recombination within a single locusGO:0002562510.020
Mouse
ubiquitin dependent protein catabolic processGO:00065111290.020
immunoglobulin production involved in immunoglobulin mediated immune responseGO:0002381430.020
Mouse
positive regulation of programmed cell deathGO:00430682180.020
ribose phosphate metabolic processGO:00196932910.020
purine nucleotide catabolic processGO:00061952110.019
response to ionizing radiationGO:0010212420.019
purine containing compound catabolic processGO:00725232130.019
regulation of histone h3 k36 methylationGO:000041410.019
Mouse
chromatin organizationGO:00063252060.019
Mouse
modification dependent protein catabolic processGO:00199411330.019
negative regulation of cellular component organizationGO:00511291940.019
camera type eye developmentGO:00430102660.019
oxidation reduction processGO:00551143420.019
ras protein signal transductionGO:0007265770.019
intracellular protein transportGO:00068862040.019
proteolysis involved in cellular protein catabolic processGO:00516031470.019
mitotic cell cycleGO:00002781950.019
nucleoside monophosphate metabolic processGO:0009123850.019
cytoplasmic transportGO:00164822340.019
membrane organizationGO:00610242450.019
meiotic nuclear divisionGO:00071261150.018
organic hydroxy compound metabolic processGO:19016152030.018
small gtpase mediated signal transductionGO:0007264970.018
positive regulation of cell deathGO:00109422240.018
cation transmembrane transportGO:00986552660.018
somatic diversification of immunoglobulinsGO:0016445430.018
Mouse
nitrogen compound transportGO:00717052710.018
purine ribonucleoside triphosphate catabolic processGO:00092071990.018
negative regulation of protein metabolic processGO:00512482820.018
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781940.018
regulation of intracellular transportGO:00323861590.018
protein catabolic processGO:00301632210.018
negative regulation of cellular amino acid metabolic processGO:004576300.018
cytokine productionGO:00018163190.018
b cell mediated immunityGO:0019724710.018
Mouse
peptidyl amino acid modificationGO:00181933360.017
Mouse
cellular component assembly involved in morphogenesisGO:00109271390.017
negative regulation of cellular protein metabolic processGO:00322692470.017
ribonucleotide catabolic processGO:00092612080.017
carboxylic acid biosynthetic processGO:0046394860.017
monocarboxylic acid metabolic processGO:00327871910.017
cellular homeostasisGO:00197252400.017
cell activation involved in immune responseGO:00022631260.017
Mouse
transmembrane transportGO:00550854120.017
reactive oxygen species metabolic processGO:0072593840.016
glucose homeostasisGO:00425931280.016
regulation of cell cycleGO:00517262810.016
regulation of cytokine productionGO:00018172660.016
meiotic cell cycle processGO:1903046770.016
cellular chemical homeostasisGO:00550822150.016
covalent chromatin modificationGO:00165691630.016
Mouse
regulation of establishment of protein localizationGO:00702011810.016
cellular response to hormone stimulusGO:00328701500.016
response to insulinGO:00328681000.015
lateral inhibitionGO:004633110.015
male gamete generationGO:00482322850.015
somatic recombination of immunoglobulin genes involved in immune responseGO:0002204360.015
Mouse
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:00024601450.015
Mouse
nuclear transportGO:00511691390.015
organelle assemblyGO:00709251770.015
inner cell mass cell proliferationGO:0001833150.015
divalent metal ion transportGO:00708381720.015
chromatin modificationGO:00165681870.015
Mouse
meiotic cell cycleGO:00513211220.015
protein localization to nucleusGO:00345041210.015
cilium assemblyGO:0042384810.015
cellular response to cytokine stimulusGO:00713451890.015
blastocyst developmentGO:0001824800.015
germ cell developmentGO:00072811850.015
engulfment of apoptotic cellGO:004365230.015
negative regulation of intracellular signal transductionGO:19025321670.015
leukocyte activation involved in immune responseGO:00023661260.014
Mouse
positive regulation of protein modification processGO:00314012990.014
Mouse
angiogenesisGO:00015252010.014
skeletal system developmentGO:00015013560.014
ion transmembrane transportGO:00342203610.014
regulation of homeostatic processGO:00328441820.014
regulation of cell activationGO:00508652890.014
Mouse
divalent inorganic cation transportGO:00725111780.014
carbohydrate homeostasisGO:00335001280.014
sensory organ morphogenesisGO:00905962420.014
regulation of cell cycle processGO:00105641600.014
regulation of cellular catabolic processGO:00313292420.014
regulation of defense response to bacteriumGO:190042430.014
antimicrobial peptide productionGO:000277520.014
response to organic cyclic compoundGO:00140701980.014
regulation of nucleotide metabolic processGO:00061401690.014
spermatogenesisGO:00072832840.014
somatic cell dna recombinationGO:0016444510.014
Mouse
organophosphate biosynthetic processGO:00904071220.014
negative regulation of dna replicationGO:000815640.014
immunoglobulin productionGO:0002377730.014
Mouse
regulation of multi organism processGO:00439001110.014
myeloid cell differentiationGO:00300992330.014
recombinational repairGO:0000725210.013
protein localization to organelleGO:00333651850.013
t cell activationGO:00421102890.013
inorganic ion transmembrane transportGO:00986602340.013
negative regulation of protein modification processGO:00314001630.013
protein alkylationGO:0008213810.013
Mouse
regulation of hormone levelsGO:00108172110.013
somatic diversification of immunoglobulins involved in immune responseGO:0002208360.013
Mouse
ribonucleoside monophosphate metabolic processGO:0009161800.013
endocytosisGO:00068971680.013
protein targetingGO:00066051430.013
protein processingGO:00164851630.013
multicellular organismal homeostasisGO:00488711640.013
carbohydrate metabolic processGO:00059752300.013
purine nucleoside monophosphate metabolic processGO:0009126810.013
calcium ion transportGO:00068161590.013
regulation of purine nucleotide metabolic processGO:19005421690.013
response to peptideGO:19016521360.013
cellular response to gamma radiationGO:007148040.013
anion transportGO:00068201770.013
regulation of antimicrobial peptide biosynthetic processGO:000280510.013
nuclear importGO:0051170950.012
meiosis iGO:0007127600.012
cellular response to lipidGO:00713961450.012
regulation of neuron differentiationGO:00456642810.012
response to extracellular stimulusGO:00099911270.012
leukocyte differentiationGO:00025213420.012
carbohydrate derivative biosynthetic processGO:19011371830.012
respiratory system developmentGO:00605411900.012
mrna metabolic processGO:0016071840.012
phospholipid metabolic processGO:0006644870.012
fat cell differentiationGO:00454441600.012
antimicrobial peptide biosynthetic processGO:000277720.012
hematopoietic progenitor cell differentiationGO:00022441430.012
response to inorganic substanceGO:0010035960.012
response to molecule of bacterial originGO:00022371430.012
regulation of antimicrobial humoral responseGO:000275930.012
cell adhesionGO:00071553290.012
sensory perceptionGO:00076002450.012
transmission of nerve impulseGO:0019226760.012
alcohol metabolic processGO:00060661160.012
homeostasis of number of cellsGO:00488722100.012
positive regulation of lymphocyte activationGO:00512511400.012
Mouse
macromolecule methylationGO:00434141200.012
Mouse
regulation of proteolysisGO:00301621640.012
lymphocyte differentiationGO:00300982420.012
single organism nuclear importGO:1902593950.012
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071692470.012
cellular response to growth factor stimulusGO:00713631970.012
response to growth factorGO:00708481980.012
urogenital system developmentGO:00016552610.012
response to oxidative stressGO:00069791230.012
inorganic cation transmembrane transportGO:00986622070.012
epithelial tube morphogenesisGO:00605623030.012
regulation of lymphocyte activationGO:00512492400.011
Mouse
response to lipopolysaccharideGO:00324961280.011
regulation of cytoplasmic transportGO:19036491120.011
forebrain developmentGO:00309003020.011
monocarboxylic acid biosynthetic processGO:0072330610.011
positive regulation of cytokine productionGO:00018191740.011
negative regulation of cell developmentGO:00107211690.011
glycerolipid metabolic processGO:00464861220.011
locomotory behaviorGO:00076261950.011
mrna processingGO:0006397630.011
microtubule cytoskeleton organizationGO:00002261570.011
action potentialGO:0001508780.011
mitotic cell cycle processGO:19030471590.011
lipid localizationGO:00108761260.011
positive regulation of cell activationGO:00508671580.011
Mouse
modification dependent macromolecule catabolic processGO:00436321330.011
multicellular organismal signalingGO:0035637910.011
rho protein signal transductionGO:0007266320.011
sequestering of metal ionGO:0051238190.011
response to light stimulusGO:00094161350.011
regulation of reactive oxygen species metabolic processGO:2000377400.011
regulation of ossificationGO:00302781120.011
glycerophospholipid metabolic processGO:0006650710.011
sequestering of calcium ionGO:0051208180.011
response to peptide hormoneGO:00434341270.011
regulation of histone h3 k4 methylationGO:0051569120.011
Mouse
nucleocytoplasmic transportGO:00069131390.011
g protein coupled receptor signaling pathwayGO:00071862430.011
gland developmentGO:00487323300.011
purine ribonucleoside monophosphate metabolic processGO:0009167800.011
embryonic organ morphogenesisGO:00485622760.011
regulation of antimicrobial peptide productionGO:000278410.011
regulation of transferase activityGO:00513382630.011
positive regulation of transferase activityGO:00513471670.011
cellular response to organic cyclic compoundGO:0071407870.011
regulation of secretionGO:00510462740.011
regulation of defense responseGO:00313472330.011
striated muscle tissue developmentGO:00147062930.011
neuron apoptotic processGO:00514021420.011
response to acid chemicalGO:00011011110.011
regulation of protein transportGO:00512231630.011
extrinsic apoptotic signaling pathwayGO:00971911260.011
regulation of lipid metabolic processGO:00192161180.011
inflammatory responseGO:00069542440.011
compound eye developmentGO:004874910.011
amide transportGO:00428861380.011
regulation of system processGO:00440572000.011
fatty acid metabolic processGO:00066311210.011
spermatid differentiationGO:00485151150.010
cell type specific apoptotic processGO:00972852680.010
posttranscriptional regulation of gene expressionGO:00106081550.010
response to nutrient levelsGO:00316671090.010
positive regulation of purine nucleotide metabolic processGO:19005441140.010
cofactor metabolic processGO:0051186800.010
negative regulation of phosphorylationGO:00423261660.010
negative regulation of phosphate metabolic processGO:00459361840.010
innate immune responseGO:00450871570.010
positive regulation of protein phosphorylationGO:00019342420.010
cellular protein complex assemblyGO:00436231160.010
regulation of secretion by cellGO:19035302490.010
peptidyl lysine modificationGO:0018205770.010
Mouse
dna alkylationGO:0006305430.010
spermatid developmentGO:00072861080.010
protein importGO:00170381010.010
positive regulation of nucleotide metabolic processGO:00459811140.010
intracellular mrna localizationGO:000829840.010
tissue homeostasisGO:00018941150.010
muscle tissue developmentGO:00605373080.010

Mdc1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of cellular proliferationDOID:1456600.084
cancerDOID:16200.084
organ system cancerDOID:005068600.081
nervous system diseaseDOID:86300.029
disease of anatomical entityDOID:700.029
hematopoietic system diseaseDOID:7400.024
immune system diseaseDOID:291400.024
immune system cancerDOID:006008300.017
hematologic cancerDOID:253100.017
sensory system diseaseDOID:005015500.015
eye and adnexa diseaseDOID:149200.015
thoracic cancerDOID:509300.013
bone marrow diseaseDOID:496100.012
eye diseaseDOID:561400.012
anemiaDOID:235500.011
aplastic anemiaDOID:1244900.011
central nervous system diseaseDOID:33100.010